CN105169099A - Traditional Chinese medicine recovery formula for curing paraquat poisoning - Google Patents

Abstract

The invention aims at providing a traditional Chinese medicine recovery formula for curing paraquat poisoning. By taking the traditional Chinese medicine theories of clearing lung, nourishing liver, tonifying kidney and eliminating toxin as rules of treatment, lung deficiency and body fluid and qi losing moistening and nourishing of a patient are corrected by tonifying spleen, so the liver is dredged to have loose bowels, and qi and blood are orderly reached; the renal excretion capacity is enhanced to stop pulmonary fibrosis from worsening and important organs, such as liver and kidney, from being damaged. The traditional Chinese medicine recovery formula provided by the invention comprises the following medicinal materials which can be used as both food and medicine: liquorice, rhizoma polygonati, barley, Poria cocos, Houttuynia cordata, Chinese yam, mulberry, jasmine and lotus seed.

Description

A kind of Chinese medicinal recovery formula being used for the treatment of paraquat poisoning

Technical field

The present invention relates to a kind of Chinese medicinal recovery formula being used for the treatment of paraquat poisoning, belong to pharmaceutical compounding techniques field.

Background technology

N,N'-dimethyl-.gamma..gamma.'-dipyridylium (PQ) is a kind of herbicide (herbicide) killing weeds strongly, has very strong toxic action to people, animal.Great majority orally cause poisoning owing to wrongly taking or committing suiside, and oral ingestion mortality rate is high, but also can absorb poisoning lethal through skin and breathing, and adult's lethal dose is 20% aqueous solution 5 ~ 15 milliliters (20 ~ 40mg/kg).N,N'-dimethyl-.gamma..gamma.'-dipyridylium absorbs through digestive tract, skin and respiratory tract, toxicity involves the multiple internal organs of whole body, multiple organ dysfunction syndrome (MODS) can be caused time serious, lung is first target organs, can cause " paraquat lung ", Early manifestation is acute lung injury (ALI) or adult respiratory distress syndrome (ARDS), and the later stage occurs in alveolar and interstitial pulmonary fibrosis, be the main cause that paraquat poisoning is lethal, case fatality rate is up to 50% ~ 70%.Intoxicating phenomenon is skin through contacting with N,N'-dimethyl-.gamma..gamma.'-dipyridylium, oral cavity, throat, mucous membrane of esophagus have and corrode and fester, and causes the multiple organ failure, MOF such as liver, kidney, lung fibrosis and respiratory failure.Within 1-20 day, organ failure or pulmonary fibrosis is died from after report case is generally poisoning.

N,N'-dimethyl-.gamma..gamma.'-dipyridylium Therapeutic Method is few, and domestic and international little for paraquat poisoning method at present, the oral absorption rate of PQ is 5% ~ 10%, and major part is with defecate, and after absorption, 1 ~ 4h reaches peak serum concentration and extensively distributes in vivo rapidly.It is uniquely by the Therapeutic Method affirmed that hemodialysis and hemoperfusion remove PQ from blood.

In addition, have hormone high dose chemotherapy, immunosuppressant is as treated with cyclophosphamide pulse method, but all not fully up to expectations, and treatment also has after leaving hospital because the important organ such as pulmonary fibrosis and Liver and kidney dies of exhaustion the case of dying, therefore the follow-up rehabilitation of N,N'-dimethyl-.gamma..gamma.'-dipyridylium patient just seems particularly necessary.

The follow-up rehabilitation that the present invention is N,N'-dimethyl-.gamma..gamma.'-dipyridylium patient provides a kind of useful integration of edible and medicinal herbs Chinese medicinal recovery formula.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicinal recovery formula for the treatment of paraquat poisoning, with theories of Chinese medical science such as lung heat clearing nourishing the liver, kidney-replenishing, toxicant-expellings for the rule for the treatment of, the deficiency of the lung functional activities of the body fluid being corrected patient by spleen reinforcing loses in moistening foster, liver is dredged have loose bowels, bar reaches QI and blood, and strengthen renal excretion water liquid ability, stop pulmonary fibrosis to increase the weight of the reparation with the damage of the important organ such as Liver and kidney.

Chinese medicinal recovery formula of the present invention comprises the medical material of following integration of edible and medicinal herbs: Radix Glycyrrhizae, Rhizoma Polygonati, Semen Coicis, Poria, Herba Houttuyniae, Rhizoma Dioscoreae, Fructus Mori, Fructus Gardeniae and Semen Nelumbinis.In formula, selected medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and can resistance of human body be strengthened, improve internal organs self-repairing capability, short treating period, instant effect, formula Chinese crude drug is integration of edible and medicinal herbs food materials, safe and reliable, without any side effects, cost is low, clinic wide popularization and application.

For achieving the above object, technical scheme of the present invention is implemented as follows:

Chinese medicinal recovery formula of the present invention, the Chinese crude drug being integration of edible and medicinal herbs in formula comprises the medical material of following ratio:

Radix Glycyrrhizae 15-30 gram, Rhizoma Polygonati 15-30 gram, Semen Coicis 10-20 gram, Poria 10-20 gram, Herba Houttuyniae 5-10 gram, Rhizoma Dioscoreae 5-20 gram, Fructus Mori 5-20 gram, Fructus Gardeniae 5-15 gram and Semen Nelumbinis 5-15 gram.

Described Chinese medicinal recovery formula optimum combination ratio comprises:

15 grams, Radix Glycyrrhizae, Rhizoma Polygonati 15 grams, Semen Coicis 10 grams, 10 grams, Poria, Herba Houttuyniae 5 grams, Rhizoma Dioscoreae 5 grams, Fructus Mori 5 grams, Fructus Gardeniae 5 grams and 5 grams, Semen Nelumbinis.

Also the medical material of following ratio is comprised:

30 grams, Radix Glycyrrhizae, Rhizoma Polygonati 30 grams, Semen Coicis 20 grams, 20 grams, Poria, Herba Houttuyniae 10 grams, Rhizoma Dioscoreae 20 grams, Fructus Mori 20 grams, Fructus Gardeniae 15 grams and 15 grams, Semen Nelumbinis.

Described Chinese medicinal recovery formula can make the dosage form that any one is used for the treatment of paraquat poisoning use clinically, and consider patient's taking convenience, we recommend oral dosage form as forms such as tablet, electuary, pill, effervescent tableies.

Detailed description of the invention

Below in conjunction with the example of Chinese medicine composition of the present invention, the specific embodiment of the present invention is described.

Formula: 15 grams, Radix Glycyrrhizae, Rhizoma Polygonati 15 grams, Semen Coicis 10 grams, 10 grams, Poria, Herba Houttuyniae 5 grams, Rhizoma Dioscoreae 5 grams, Fructus Mori 5 grams, Fructus Gardeniae 5 grams and 5 grams, Semen Nelumbinis.

Preparation: get Semen Coicis, Rhizoma Dioscoreae and Semen Nelumbinis in above medical material and fry and directly beat powder, remaining medical material water extraction three times, each 2 hours afterwards, collect three extracting solution and be concentrated into extractum, dry beat powder, the Semen Coicis beating powder in above-mentioned, Rhizoma Dioscoreae and Semen Nelumbinis powder mix, granulate, pack, every packed 15g.

clinical case data:

1, case selection:

Patients with paraquat poisoning 22 example made a definite diagnosis with Xijing hospital emergency department, patient is divided into treatment group and matched group two groups at random, treatment group 12 example, wherein male 5 example, women 7 example, 15 ~ 55 years old age, 42.5 years old mean age; Matched group 10 example, wherein male 4 example, women 6 example, 17 ~ 61 years old age, 44 years old mean age.

The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.

2, formulation selection:

Treatment group takes the electuary (Semen Coicis, Rhizoma Dioscoreae and Semen Euryales fry and beat powder, and remaining medicinal material extract concentrates, and beat mixing granulation after powder, make packed electuary) of formula of the present invention, oral, every day 2 times, each 1 time of morning and evening, each 15g.

Matched group takes similar electuary sesame paste, and dose is with to take mode identical.

3, efficacy determination:

(1) cure: symptom and sign disappears, and physical recovery is normal.

(2) take a turn for the better: symptom and sign obviously alleviates, and health is clearly better.

(3) invalid: symptom and sign is without alleviating.

4, result:

Result is as shown in table 1:

Table 1 liang group patient takes the Comparison of therapeutic of formula rehabilitation impact of the present invention and sesame paste respectively

Group	Case load	Cure	Take a turn for the better	Invalid	Effective percentage
						Treatment group	12	5	4	3	75%
Matched group	10	2	3	5	50%

Observe check result and inquiry patient after one week, treatment group shows every check result and all has clear improvement, and N,N'-dimethyl-.gamma..gamma.'-dipyridylium blood, urine concentration significantly decline, patient's private prosecution physical recovery is good, smooth breathing, urine volume increase etc., after continuing to take formula of the present invention, health is obviously felt to take a turn for the better.The every check result of matched group takes a turn for the better after hemoperfusion and hemodialysis and heavy dose of pulse treatment with methylprednisolone, and some patients still has pulmonary fibrosis to occur, dyspnea, hepatic and renal function improves not obvious, have weak during patient's private prosecution, dyspnea, do not continue the hope taking sesame paste.

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Claims (4)

1. treat a Chinese medicinal recovery formula for paraquat poisoning, it is characterized in that the Chinese crude drug being integration of edible and medicinal herbs in formula:

Radix Glycyrrhizae 15-30 gram, Rhizoma Polygonati 15-30 gram, Semen Coicis 10-20 gram, Poria 10-20 gram, Herba Houttuyniae 5-10 gram, Rhizoma Dioscoreae 5-20 gram, Fructus Mori 5-20 gram, Fructus Gardeniae 5-15 gram and Semen Nelumbinis 5-15 gram.

2. the Chinese medicinal recovery formula of paraquat poisoning according to claim 1, is characterized in that the Chinese crude drug that formula comprises and proportioning thereof are:

15 grams, Radix Glycyrrhizae, Rhizoma Polygonati 15 grams, Semen Coicis 10 grams, 10 grams, Poria, Herba Houttuyniae 5 grams, Rhizoma Dioscoreae 5 grams, Fructus Mori 5 grams, Fructus Gardeniae 5 grams and 5 grams, Semen Nelumbinis.

3. the Chinese medicinal recovery formula of paraquat poisoning according to claim 1, is characterized in that the Chinese crude drug that formula comprises and proportioning thereof are:

30 grams, Radix Glycyrrhizae, Rhizoma Polygonati 30 grams, Semen Coicis 20 grams, 20 grams, Poria, Herba Houttuyniae 10 grams, Rhizoma Dioscoreae 20 grams, Fructus Mori 20 grams, Fructus Gardeniae 15 grams and 15 grams, Semen Nelumbinis.

4. the Chinese medicinal recovery formula of the paraquat poisoning according to any one of claim 1-3, is characterized in that described rehabilitation formula medical material is oral dosage form, comprises the form such as tablet, electuary, pill, effervescent tablet conveniently taken.