CN102579849B - Sodium valproate and preparation process thereof - Google Patents
Sodium valproate and preparation process thereof Download PDFInfo
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Abstract
The invention relates to compound sodium valproate and a preparation process thereof. The sodium valproate is prepared by raw materials including sodium valproate 0.3 part, salvia miltiorrhiza 30 parts, pepper 25 parts, rhizoma nardostachyos 20 parts, gastrodia elata 12 parts and uncaria 10 parts by weight, and the sodium valproate is prepared into capsules, tablets, particles and other drug forms after pharmaceutical excipients such as starch or edible cellulose are added according to a common pharmacy method. A compound sodium valproate drug composition treats both principal and secondary aspect of epilepsia disease, is non-toxic harmless and free of side effect to human body, low in price, simple and convenient to manufacture, and has wide application prospect.
Description
Technical field
The invention belongs to medical technical field, be specifically related to treat the Chinese-western medicine preparation of epilepsy, the application of medicine in epilepsy that the Western medicine sodium valproate of particularly take is made as main and Chinese herbal medicine.
Background technology
Epilepsy (Epilepsy, EP) be due to the temporary excessive high-frequency discharge of cerebral neuron group caused a kind of repeatedly, of short duration ictal functional disorders of brain syndrome.Show as break out, automatic stop, the obstacle of recurrent motion, sensation, spirit and consciousness aspect, be chronic convulsibility disease.According to incompletely statistics, the current epilepsy invasion rate of China is in 6 ‰ left and right, and the patient nearly 9,000,000, and annual 450000 the new patient of also having an appointment.Most research discovery, male's epilepsy invasion rate is 57.1%, higher than women 42.7% sickness rate, the rural area sickness rate is higher than the cities and towns sickness rate.According to the academic meeting of the 5th, whole nation epileptics, disclose, in the epilepsy crowd of China, the patient more than 40% never carried out treatment, and what 35% patient accepted is irregular treatment, and its disability rate and mortality rate are also higher, have become the problem that is worth society to pay attention to.So, develop new antuepileptic and become the task of top priority.
Research datas prove in a large number, and psychomotor reason is varied although cause.But the outbreak of epilepsy, be all because the irritability of axoneure is too high, thereby occur widely, the result of synchronicity high-frequency discharge.According to the achievement in research in past, think to various epilepsy it is all identical, therefore, treatment measure accordingly is to use tranquilizer, suppresses the rapid diffusion of exaltation and the inhibition high-frequency discharge of axoneure, this has positive effect to controlling epilepsy.
Sodium valproate (Sodium Valproate) is a saturated fatty acid sodium salt, and chemical name is valproate, and structural formula is
By French Meurier, confirmed first antiepileptic action in 1963, China trial-produceed successfully in 1977.Confirmed that now sodium valproate is all effective in cure to various epilepsy, the sodium valproate mechanism of action is relevant with inhibition voltage sensitivity Na+ passage; Suppress γ-aminobutyric acid (GABA) metabolic enzyme, GABA in brain is built up, suppress focus neuron over-discharge, contain simultaneously the diffusion of paradoxical discharge.VPA can treat various epilepsy, total effective rate is greater than 83%, wherein to simple absence seizure, it is best that complete tetanus-Myoclonic seizures (GTC), GTC merge the petit mal curative effect, simple partial seizure (SP) and complex partial seizures (CP) curative effect are taken second place, and acquired epilepsy aphasia, S sleep are continued to spike and ware wave epilepsy and tonic seizures mutually also effective.Sodium valproate curative effect wide spectrum, effect are good, have risen at present the choice drug of PGE.Yet the patient, in Long-term taking medicine, shows toxicity in various degree, can have influence on the function of a plurality of systems such as nervus centralis, breathing, digestion, hemopoietic, urinary system: lax as drowsy, hypomnesis, attention.Bradykinesia, mood change, even cause thought disturbance, as melancholy, personality is abnormal etc., with regard to, late result obtained in the recent period with regard to it, result is unsatisfactory.
The traditional Chinese medical science thinks that the pathological change of insane pain is the parent suddenly frightened, causes first mechanism of qi contrary disorderly, causes first the essence wound and deficiency of the kidney, so-called " probably essence but ", fetal development is produced abnormal, and secondary evidence occurs after birth, and this is due to congenital factors.Due to acquired disposition, epilepsy syndrome, mainly due to terrified and intemperance of taking food, causes visceral dysfunction: suddenly suffering intense fright and dread, cause mechanism of qi disorderly contrary, " excessive fear leading to sinking of kidney-QI ", " excessive fright leading to disturbance of QI ", and then damage internal organs, as impaired as Liver and kidney, can make hepatic and renal YIN deficiency, give birth to hot air wind producing, the impaired strong mistake department that transports of taste, expectorant is turbid cohesion, and one meets inducement, on wind-fire and phlegm-heat, alters brain god, hoodwink the clear key of the mind, and send out epilepsy.If feelings will is not relaxed, overfatigue, depression of liver-QI, liver-wind folder expectorant superinverse, inaccessible thinking, the meridians that are jammed, also can send out as epilepsy.In addition, after the brain wound, mind is disorderly contrary, qi and blood stagnation, and the channels discord, also can send out as epilepsy.Epilepsy and the dirty relation of kidney,liver,spleen three are the closest, and change of pathogenesis and wind, expectorant, the stasis of blood are relevant, especially with the expectorant heresy, haunt the most important.The Chinese traditional treatment epilepsy is by adjusting human body yin-yang balancing and function to recover the allomeric function state of body, according to the etiology and pathogenesis difference, and method for the treatment of rule for the treatment of difference, dialectical treating.The Chinese medicine epilepsy has the advantages such as the medicine source is wide, method is various, toxic and side effects is little, avoids the Western medicine antuepileptic to cause the side effect such as drowsiness, cognitive dysfunction, hemopoietic system inhibition; Some Chinese medicine also has dual regulation, has the whole body of adjusting function, strengthens the effect of immunologic function.Therefore the Chinese medicine and western medicine compound drug of seeking a kind of high-efficiency low-toxicity, treating both the principal and secondary aspects of a disease is the technical barrier of pendulum in face of medical circle.
Summary of the invention
The purpose of this invention is to provide that a kind for the treatment of both the principal and secondary aspects of a disease, side effect are little, safe ready, cheap valproate compound medicine.Its objective is in order to solve the treatment epilepsy, overcome the onset of Western medicine sodium valproate slow, and easily knock-on, the problem that toxic and side effects is large, reach the purpose for the treatment of both the principal and secondary aspects of a disease.
The present application people is according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house, filter out the natural Chinese medicine of benefiting QI for activating blood circulation, tranquillizing and allaying excitement, by the theory of Chinese medical science prescription, in conjunction with the Traditional Chinese Medicine technology, meticulously be mixed with the valproate compound pharmaceutical composition for the treatment of epilepsy of the present invention, epilepsy is had to the effect of taking stopgap measures and effecting a permanent cure.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of valproate compound pharmaceutical composition, is characterized in that it is obtained by the preparation of following weight proportioning raw material,
Sodium valproate 0.2-0.5 part, Radix Salviae Miltiorrhizae 30-50 part, Fructus Piperis 20-30 part, Radix Et Rhizoma Nardostachyos 20-25 part, Rhizoma Gastrodiae 10-15 part, Ramulus Uncariae Cum Uncis 8-10 part.
Preferably, described raw material weight proportioning is:
0.3 part of sodium valproate, 30 parts of Radix Salviae Miltiorrhizaes, 25 parts, Fructus Piperis, 20 parts of Radix Et Rhizoma Nardostachyos, 12 parts, Rhizoma Gastrodiae, 10 parts of Ramulus Uncariae Cum Uncis
Wherein said sodium valproate can commercially availablely be bought, and preferably preparation method is:
1, charge ratio
2, production technology
2,1 alkylation
Retort is slightly dried, the suction n-Propyl Bromide, add K2CO3 and TBAB, the sealed cans mouth, open and stir and open vapour to the dropping methyl acetoacetate that refluxes, dripped off in 10 minutes, atmospheric pressure reflux 1 hour, then pressurization refluxes after 2 hours (pressure 0.2-0.4Mpa), then at 70 ℃, adds water 200L rising temperature for dissolving, close vapour and stop stirring standing 15 minutes minutes water-yielding stratums, obtain crude extract 200kg.By in crude extract suction retort, to open stirring, open vapour, normal pressure steams to water base not go out, the distilling under reduced pressure front-end volatiles, 112-118 ℃ of fraction collected in decompression (0.08Mpa) distillation, obtains component A
2,2 deacylated tRNAs
By Feldalat NM, methanol (by component A: Feldalat NM: methanol=65: 16: 15 mass ratioes) in the suction retort, open stirrings, open vapour to backflow, reflux and start to distill front-end volatiles after 1 hour, be cooled to 90 ℃ and emit deacylated tRNA thing 65kg.
2,3 alkaline hydrolysis
Open stirring, by the 40%NaOH for preparing (deacylated tRNA thing: NaOH=65: 12 mass ratioes) drop into rapidly the deacylated tRNA thing in the suction still immediately, open after vapour refluxed 2 hours and add water 30L, steam the first alcohol and water to 96-98 ℃ only, adjust PH9-10, then use toluene (30kg/ time) to extract 3 times, be acidified to PH=2, bleed off water layer in standing 15 minutes, and obtained thick valproic acid 70kg.By in thick valproic acid suction still, open to stir and open vapour normal pressure steaming toluene and water, when decompression steaming front-end volatiles to temperature is stablized when not going out, emit front-end volatiles, continue decompression and steam valproic acid, until substantially only do not go out, require vacuum at 0.08-0.1Mpa, vapour pressure>0.55Mpa, obtain smart valproic acid 50kg.
2,4 salifies
Smart valproic acid is dropped in pot, and with 20%NaOH, being adjusted to PH is 10.2 left and right.Then open vapour concentrated, sabot is in 100 ℃ of oven dry, and turns in good time, dries to obtain sodium valproate 56kg.When filling with substance will be used double-layer plastic bag.
2,5 is refining:
The 50kg sodium valproate is dropped in the refining reaction tank, add water 10L, open stirring, heat, after sodium valproate dissolves, drip hydrochloric acid solution, during to PH2, stop dripping, the intensification distilling under reduced pressure, when fraction is clarified, start to receive, with 20%NaOH, being adjusted to PH is 10.2 left and right, stirred 10 minutes, and resurveyed once.Then open vapour concentrated, sabot is in 100 ℃ of oven dry, and turns in good time, dries to obtain sodium valproate 48kg.When filling with substance will be used double-layer plastic bag.
Pharmaceutical composition of the present invention comprises the pharmaceutical preparation for the conjoint therapy of gastrointestinal administration, as film coating, tablet, capsule.If not otherwise specified, these preparations are to be prepared by known method own.For example with conventional mixing, granulation, tabletting, coating, dissolving or freeze-drying, prepare.
When preparing the compositions of peroral dosage form administration, can use conventional media, for example water, alcohols, glycols, oils; Prepare oral solid formulation class such as powder, tablet, drop pill, capsule, operable carrier, as starch, saccharide, microcrystalline Cellulose, magnesium stearate, cross-linked pvp, micropowder silica gel, diluent, granulating agent, lubricant, binding agent, disintegrating agent etc.
Preferably, described valproate compound pharmaceutical composition preparation method is: get sodium valproate 0.3g, Radix Salviae Miltiorrhizae 30g, Fructus Piperis 25g, Radix Et Rhizoma Nardostachyos 20g, Rhizoma Gastrodiae 12g, Ramulus Uncariae Cum Uncis 10g, through pulverizing, make capsule according to a conventional method, every 0.5g, through being up to the standards as finished product.
Technical solutions according to the invention are on the clinical experience basis of Chinese traditional treatment epilepsy, in conjunction with the compound preparation with the Chinese medicine and western medicine combination of modern pharmacy achievement development.By Chinese medicine and Western medicine combination effectively, have suppressing the hyperactive liver to arrest the wind syndrome, mind tranquilizing and the heart calming effect very doughtily, can improve rapidly symptom, stop disease, the effect that epilepsy is had to healing, overcome the onset of prior art Chinese medicine and reach slowly the shortcomings such as toxicity is large, reach the purpose for the treatment of both the principal and secondary aspects of a disease, recommend take above-mentioned valproate compound pharmaceutical composition three times, each three every day.
Valproate compound pharmaceutical composition advantage of the present invention is as follows:
1 the present invention adopts to improve one's methods and prepares sodium valproate, and its yield is higher.
2 full sides coordinate appropriate epilepsy pathogenesis, and prescription is reasonable, and drug effect is deeply lasting in order, medicine letter and power is special;
3 the present invention, by the choose reasonable to medicine components, proportioning, have obtained desirable therapeutic effect, have both met the requirement of state-promulgated pharmacopoeia to relevant drug dose, can guarantee good therapeutic effect, non-evident effect again.
The specific embodiment
Embodiment 1
A kind of valproate compound pharmaceutical composition, is characterized in that it obtains 0.3 part of sodium valproate, 30 parts of Radix Salviae Miltiorrhizaes, 25 parts, Fructus Piperis, 20 parts of Radix Et Rhizoma Nardostachyos, 12 parts, Rhizoma Gastrodiae, 10 parts of Ramulus Uncariae Cum Uncis by the preparation of following weight proportioning raw material.
Wherein said sodium valproate can commercially availablely be bought, and preferably preparation method is:
1, charge ratio
2, production technology
2,1 alkylation
Retort is slightly dried, the suction n-Propyl Bromide, add K2CO3 and TBAB, the sealed cans mouth, open and stir and open vapour to the dropping methyl acetoacetate that refluxes, dripped off in 10 minutes, atmospheric pressure reflux 1 hour, then pressurization refluxes after 2 hours (pressure 0.2-0.4Mpa), then at 70 ℃, adds water 200L rising temperature for dissolving, close vapour and stop stirring standing 15 minutes minutes water-yielding stratums, obtain crude extract 200kg.By in crude extract suction retort, to open stirring, open vapour, normal pressure steams to water base not go out, the distilling under reduced pressure front-end volatiles, 112-118 ℃ of fraction collected in decompression (0.08Mpa) distillation, obtains component A
2,2 deacylated tRNAs
By Feldalat NM, methanol (by component A: Feldalat NM: methanol=65: 16: 15 mass ratioes) in the suction retort, open stirrings, open vapour to backflow, reflux and start to distill front-end volatiles after 1 hour, be cooled to 90 ℃ and emit deacylated tRNA thing 65kg.
2,3 alkaline hydrolysis
Open stirring, by the 40%NaOH for preparing (deacylated tRNA thing: NaOH=65: 12 mass ratioes) drop into rapidly the deacylated tRNA thing in the suction still immediately, open after vapour refluxed 2 hours and add water 30L, steam the first alcohol and water to 96-98 ℃ only, adjust PH9-10, then use toluene (30kg/ time) to extract 3 times, be acidified to PH=2, bleed off water layer in standing 15 minutes, and obtained thick valproic acid 70kg.By in thick valproic acid suction still, open to stir and open vapour normal pressure steaming toluene and water, when decompression steaming front-end volatiles to temperature is stablized when not going out, emit front-end volatiles, continue decompression and steam valproic acid, until substantially only do not go out, require vacuum at 0.08-0.1Mpa, vapour pressure>0.55Mpa, obtain smart valproic acid 50kg.
2,4 salifies
Smart valproic acid is dropped in pot, and with 20%NaOH, being adjusted to PH is 10.2 left and right.Then open vapour concentrated, sabot is in 100 ℃ of oven dry, and turns in good time, dries to obtain sodium valproate 56kg.When filling with substance will be used double-layer plastic bag.
2,5 is refining:
The 50kg sodium valproate is dropped in the refining reaction tank, add water 10L, open stirring, heat, after sodium valproate dissolves, drip hydrochloric acid solution, during to PH2, stop dripping, the intensification distilling under reduced pressure, when fraction is clarified, start to receive, with 20%NaOH, being adjusted to PH is 10.2 left and right, stirred 10 minutes, and resurveyed once.Then open vapour concentrated, sabot is in 100 ℃ of oven dry, and turns in good time, dries to obtain sodium valproate 48kg.When filling with substance will be used double-layer plastic bag.
Above-mentioned composition is added as the starch living food with after the cellulose pharmaceutic adjuvant, making the dosage forms such as capsule, tablet, granule according to common pharmaceutical methods.
Preferably, described valproate compound pharmaceutical composition preparation method is: get sodium valproate 0.3g, Radix Salviae Miltiorrhizae 30g, Fructus Piperis 25g, Radix Et Rhizoma Nardostachyos 20g, Rhizoma Gastrodiae 12g, Ramulus Uncariae Cum Uncis 10g, through pulverizing, make capsule according to a conventional method, every 0.5g, through being up to the standards as finished product.
Adopt the non-clinical study method to test, in pharmacological evaluation, bringing out the Mouse and rat convulsion effect with strychnine and pentylenetetrazole, maximal electroshock is clinical petit mal epilepsy and grand mal model, screening epilepsy petit mal and grand mal medicine.100V alternating current energising 0.3s, stimulate mice ears (use the normal saline moistening), selects to the tetanic but not dead mice of pair hind legs, male and female dual-purpose after stimulating, occurring.Record mice electrofit incidence rate, observe the impact of epilepsy capsule on the maximal electroshock convulsive activity.
Gastric infusion, observe maximal electroshock and cause mice convulsion rate and tubocurarine intracerebroventricular injection and cause the anticonvulsant action that rat convulsions rate and pentylenetetrazole inducing mouse are fainted from fear.After valproate compound gastric infusion of the present invention, can reduce significantly as a result that maximal electroshock causes the mice convulsion rate and tubocurarine causes rat convulsions rate, the convulsions rate reduces to respectively 60% and 10%; Can obviously reduce the intraperitoneal perfusion strychnine and cause mice convulsion rate (the convulsions rate reduces to 15%), can obviously extend pentylenetetrazole and cause the mice convulsion induction period.Conclusion shows that valproate compound of the present invention has obvious anticonvulsant action.
Embodiment 2
Clinical data
Choose outpatient's totally 113 examples with complete case.Male 52 examples wherein, female's 61 examples; 13～57 years old age, medication person's 48 examples not fully, person's 29 examples of using the western medicine, medication person's 20 examples once in a while, intermittent use person 16 examples; Wind-phlegm impatency card 37 examples, syndrome of phlegm-heat blocking internally 35 examples, stagnation of QI-blood card 19 examples, syndrome of deficiency of both heart and spleen 18 examples, caused by liver and kidney deficiency card 4 examples; Patient is balanced according to concrete conditions such as sex, age, the state of an illness, medicining conditions, be divided into 2 groups at random, treatment group 60 examples, matched group 53 examples.
The Diagnosis of Epilepsy standard
TCM syndrome diagnostic criteria: (1) wind-phlegm impatency card: the tendencys such as uncomfortable in chest, dizzy are arranged before outbreak; During outbreak, unexpected dusk flutters, gnathospasma, two fixed staring upward, tic of the limbs, slobbering; After waking up, giddy is still arranged, god is tired, and tongue is greasy in vain, stringy and rolling pulse.(2) excess syndrome of stroke in phlegm-fire: at ordinary times or irritable before outbreak, headache and insomnia; During outbreak, go into a coma, twitch doubly very, bitter taste and dryness in the mouth, conjunctival congestion constipation, red tongue, yellow fur, stringy and rolling pulse number.(3) caused by liver and kidney deficiency card: outbreak is arranged during epilepsy syndrome, lethargy, Light-headedness, the hypophrenia, soreness of the waist and knees, red tongue, tongue is few, stringy and thready pulse.(4) syndrome of deficiency of both heart and spleen: epilepsy syndrome is sent out repeatly, spiritlessness and weakness, and palpitation and sleeplessness, forgetful giddy, the complexion rolling is white, lack of appetite, light red tongue, thin fur, thready pulse.(5) stagnation of QI-blood card: epilepsy syndrome is sent out repeatly, head twinge or localized pain, darkish complexion or dark and gloomy, purplish tongue or petechia is arranged, hesitant pulse.
The Western medicine diagnose standard: before (1) outbreak, tendency is often arranged, during outbreak, show as of short duration sensory disturbance, limbs are twitched, loss of consciousness, behavior disorder or dysautonomia, and outbreak is sanity later, weak all over; The lighter, only have unexpected god slow-witted, pale complexion, or binocular stares, and head turns forward, and the short time namely recovers normal; (2) without regularly outbreak repeatedly, the persistent period varying length, mostly namely stop to several minutes in the several seconds, more than minority reaches a few hours, revives and rear the outbreak situation is known nothing; (3) EEG (electrocardiogram) examination is abnormal.
The case of participating in the experiment standard: (1) inclusive criteria: 1. functional (constitutional) sends out the author; 2. organic (Secondary cases) sends out its inducement of author such as brain congenital anomaly, craniocerebral trauma, maternal infuries, brain infection disease, and intracranial tumor, cerebrovascular disease etc. are cured fully or controlled but still take place frequently and meet Diagnosis of Epilepsy standard person; 3. show effect per month more than 4 times.(2) Excluded cases standard: 1. with heating, the serious heating that doubtful maincenter infects or other infection cause, infecting healing, the heating person of not stopping; 2. do not get rid of other organic disease persons of cranium brain; 3. eclamposia person; 4. be associated with the serious primary disease person such as cardiovascular, liver, kidney and hemopoietic system; 5. do not meet inclusive criteria, not medication in accordance with regulations, can't judge that curative effect or data are not congruent to affect the treatment or safety judgement person.
Therapeutic Method: medication: (1) test group: 3 times/days of the embodiment of the present invention 1 valproate compound pharmaceutical compositions, oral; (2) matched group: 5 tablets/times of xianyu granules, 3 times/days, oral.1 month is 1 course for the treatment of, takes at least continuously 3 courses for the treatment of, and after 3 courses for the treatment of, the patient can freely select whether to continue medication according to curative effect, and the doctor also can provide suggestion according to the test curative effect.
Curative effect determinate standard
World epilepsy alliance efficacy assessment standard: (1) is satisfied: treat epilepsy in 3 years and disappear fully (100%), electroencephalogram recovers normal or 1～2 outbreak is arranged every year once in a while; (2) significantly improvement: epilepsy reduces 75%, or compares interval time with the front outbreak for the treatment of, extends outbreak more than 1 year, and the electroencephalogram change is clearly better; (3) good: epilepsy reduces and is greater than 50%, or the outbreak symptom obviously alleviates, and the persistent period shortens more than 1/2, and the electroencephalogram change take a favorable turn; (4) invalid: or the outbreak symptom obviously alleviates, the persistent period shortens more than 1/2, and electroencephalogram change take a favorable turn.
Statistical method: after three courses for the treatment of, χ
2Check
| Group | Example time | Cure | Significantly improve | Well | Invalid | Total effective rate |
| Treatment group | 60 | 31 | 15 | 12 | 2 | 96.7％ |
| Matched group | 53 | 19 | 18 | 10 | 6 | 88.7％ |
The total effective rate of two groups is respectively 96.7% and 88.7%, and cure rate is respectively 52% and 36%, has significant difference.
Embodiment 3
Exemplary embodiments
Chen, the female, 26 years old, before 3 years, because hyperpyrexia causes epilepsy, tic of the limbs, suddenly confused servant, stiffness of the nape and back, spat out white foams, look on gnathospasma, order eyeball, the symptoms such as urinary incontinence are occasionally arranged, each outbreak did not wait in 3-5 minute, after the outbreak spontaneous remission, the symptoms such as headache, weak, nauseating, vomiting are arranged, after a few hours, recovery is as ordinary person more.Since the patient idiopathy, once repeatedly in various big hospital diagnosis and treatment such as locality and Beijing, the state of an illness has no and is clearly better, and EEG (electrocardiogram) examination severe is abnormal, and the electric discharge of epilepsy sample is arranged.By the patient, introduce, after taking valproate compound treatment 2 courses for the treatment of of embodiment 1 preparation, symptom is controlled, and continues to strengthen treatment, and checked half a year afterwards, remain dormant and EEG (electrocardiogram) examination normal, start to subtract medicine, subtract stable disease during medicine, remain dormant, drug withdrawal after again after two courses for the treatment of, repeatedly do not follow up a case by regular visits to recurrence.
Cao, the man, 39 years old, because the cerebroma post-craniotomy causes epilepsy grand mal, during outbreak, suddenly to fall forward, dusk is not known the people, tic of the limbs is spat out white foams, gnathospasma, the tongue of breaking by the teeth.Continue 2-3 minute, show effect per month and do not wait for 1-2 time, postseizure headache, weak, take carbamazepine, sodium valproate, and symptom can not be controlled fully, and patients underwent is walked slowly, and language is not smooth, lethargy, and looking into electroencephalogram is abnormal electroencephalogram, and point-slow wave granting is arranged; Tcm diagnosis is blood stagnant in cerebral venation syndrome type epilepsy.By the patient, introduce, take in valproate compound treatment 2 courses for the treatment of of embodiment 1 preparation, once outbreak, but symptom is lighter, continue to take medicine of the present invention after two courses for the treatment of, and it is normal that electroencephalogram recovers, and recurrence is not followed up a case by regular visits in drug withdrawal after three courses for the treatment of.
Above-mentioned each Chinese medicine and western medicine that the present invention adopts is made compatibility mutually, can bring into play its collaborative effect of curing the disease, between each composition of raw material of Chinese medicine used, having drug effect is interweaved and mutually promotes and coordinate usefulness, through clinical verification, epilepsy is had to good therapeutic effect, in the applicant's medical practice for many years, the case number of curing is numerous, all obtain good effect, and with low cost, alleviate patient's burden.
The valproate compound pharmaceutical composition of the application's treatment epilepsy is with low cost, evident in efficacy, has broad application prospects.
Claims (2)
1. a valproate compound pharmaceutical composition, is characterized in that it obtains 0.3 part of sodium valproate, 30 parts of Radix Salviae Miltiorrhizaes, 25 parts, Fructus Piperis, 20 parts of Radix Et Rhizoma Nardostachyos, 12 parts, Rhizoma Gastrodiae, 10 parts of Ramulus Uncariae Cum Uncis by the preparation of following weight proportioning raw material.
2. valproate compound pharmaceutical composition claimed in claim 1 is treated the purposes in the epilepsy medicine in preparation.
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Effective date of registration: 20171122 Address after: 276600 Shandong Province Economic Development Zone Linyi city Junan County Road, Huaihai Road West first Tong Ren Pharmaceutical Co. Ltd. Patentee after: Tong Ren Pharmaceutical Co., Ltd. Address before: 276600 No. 106, democracy Road, Junan County, Linyi, Shandong Patentee before: Shandong Kernel and Hall Pharmaceutical Industry Co., Ltd. |