CN102579802A - Granules for treating hypoxia tolerance and preparation method thereof - Google Patents
Granules for treating hypoxia tolerance and preparation method thereof Download PDFInfo
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- CN102579802A CN102579802A CN2012100736707A CN201210073670A CN102579802A CN 102579802 A CN102579802 A CN 102579802A CN 2012100736707 A CN2012100736707 A CN 2012100736707A CN 201210073670 A CN201210073670 A CN 201210073670A CN 102579802 A CN102579802 A CN 102579802A
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Abstract
The invention discloses granules for treating hypoxia tolerance and a preparation method thereof. By long-term experimental study, researchers develop the granules which consist of the five Chinese medicines: red ginseng, epimedium, root of red-rooted salvia, dwarf lilyturf tuber and cassia bark. According to a formula, the components of the granules have a certain effect of improving the hypoxia tolerance and also have the effects of enhancing the immunity of organisms, resisting fatigue, invigorating brain, improving brain work and the like according to the conditions of anoxia people, so that the sub-health state of the anoxia people is improved.
Description
Affiliated technical field
The invention belongs to medical technical field, be specifically related to a kind of granule of treating anoxia enduring and preparation method thereof.
Background technology
Oxygen is that human body carries out metabolic key substance, is human life activity's primary need.The oxygen that is sucked by lung is converted into available blood oxygen in the human body, and blood carries blood oxygen to the required energy of whole body input biological oxidation, so oxygen is important substance indispensable in the normal activities.The adult is under quiescent condition, and the per minute oxygen consumption is about 250ml, and during as if activity, oxygen consumption just obviously increases.The storage level of oxygen approximately has only about 1.5L in the normal body.Work as respiratory arrest, even cylinder storage oxygen makes full use of the vital movement that also can only keep a few minutes., the various metabolic activities of general body all before intravital deposit oxygen does not also exhaust fully, just obvious obstacle can occur.Like this, body must depend on the supply of extraneous oxygen and constantly accomplish the picked-up and the transportation of oxygen through breathing, blood, blood circulation, to guarantee the needs of cell biological oxidation.
Anoxia is the pathologic basis of a lot of disease developments, and general of short duration or slight hypoxia can cause palpitating speed, blue, dizzy, the headache of lip, even symptoms such as vomiting, diarrhoea, short of breath, stupor possibly occur; Long-time or anxious degree anoxia because the body oxidative metabolism is obstructed, energy produces not enough, can cause that serious functional disorder or pathologic change, diseases such as pulmonary edema, high altitude hypotension disease, HAHD, and possibly cause vital movement stop annotate.
When the body anoxia; Histiocyte can not obtain its required enough oxygen from blood; The oxygen that maybe can not make full use of in the blood carries out the normal oxidation metabolism; Body must produce a series of adaptation responsies to anoxia in order to survive, and the abduction delivering specific gene participates in keeping body oxygen stable state, reduces cell to the dependency need of oxygen or increase oxygen from the picked-up in the external world with improve the transportation to tissue.The energy that the vital movement of human body will lean on the food oxidation to produce is kept, if the not enough or insufficient utilization in the source of oxygen in the body, oxygen metabolism will be hindered, and causes energy exhaustion, and vital movement stops.
Research worker of the present invention is through secular experimentation; Develop the pharmaceutical composition of forming by Radix Ginseng Rubra, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Ophiopogonis and Cortex Cinnamomi five kinds of Chinese medicine; These article prescription is generation reason, the anoxia symptom in the analysis-by-synthesis anoxic conditions, anoxia crowd's situation; And be foundation with modern pharmacology research, form in conjunction with the functional characteristics prescription of chemistry that is mainly used in anoxic conditions at present and natural product.Immunity, resisting fatigue, the brain-strengthening of enhancing body, the effects such as efficient of raising mental work are played in the improve effect of anoxia endurance of prescription constituent equal tool, and can be to anoxia crowd's situation simultaneously, improve anoxia crowd's sub-health state.
Summary of the invention
Research worker of the present invention is developed the granule of being made up of Radix Ginseng Rubra, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Ophiopogonis and Cortex Cinnamomi five kinds of Chinese medicine through lot of experiments.
The object of the present invention is to provide a kind of granule of treating anoxia enduring.
The objective of the invention is to further provide the method for preparing of the granule of treating anoxia enduring.
The present invention also aims to provide the application of this granule in field of medicaments
The present invention realizes through following technical scheme:
Medicinal granule prescription of the present invention is formed:
Radix Ginseng Rubra, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Cortex Cinnamomi
Medicinal granule prescription amount ranges of the present invention:
Radix Ginseng Rubra 10-30g, Radix Salviae Miltiorrhizae 40-60g, Herba Epimedii 30-50g, Cortex Cinnamomi 10-20g, 30-40g Radix Ophiopogonis medicinal granule prescription of the present invention consumption optimum:
Radix Ginseng Rubra 20g, Radix Salviae Miltiorrhizae 50g, Herba Epimedii 40g, Cortex Cinnamomi 15g, Radix Ophiopogonis 35g
The method for preparing of medicinal granule of the present invention:
Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Cortex Cinnamomi and Radix Ophiopogonis powder are broken into the granule less than 4mm, and wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 5-8 times of water gaging immersion 4-8h, kept the slight boiling condition reflux, extract, 6-10 hour, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 1-3h that 8-12 doubly measures 50-70%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; Merge extractive liquid, 60-80 ℃ decompression recycling ethanol is not to there being the alcohol flavor, continues to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions; Vacuum 0.10MPa drying under reduced pressure to moisture is below 5%; Pulverize, cross 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 1-3h, hide 20-30h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
The specific embodiment
Zoopery:
The normal pressure hypoxia endurance test: selected for use for 6～8 weeks (20 ± 2g) mices, male and female all can, single sex is no less than 10 for every group; Each dose groups per os gave this product of variable concentrations 20～30 days continuously, and matched group gives equal capacity solvent, after last is irritated stomach 1 hour; Each group mice is put into the 250mL ground wide mouthed bottle (1 every bottle) that fills the 15g sodica calx respectively, seal bottleneck, cover completely with vaseline; Making it air tight timing immediately, is index with the respiratory arrest, observes mice because of the dead time of anoxia.Sodium nitrite poisoning survival test: select body weight 20 ± 2g healthy mice, male and female all can, single sex is no less than 10 for every group.Each dose groups per os gave this product of variable concentrations 20～30 days continuously; Matched group gives equal capacity solvent, and after last is irritated stomach 1 hour, the equal lumbar injection sodium nitrite solution of each treated animal 200～240mg/kg.bw (0.1ml/10g); Timing immediately, the record animals survived time.
Assay: each dosage can improve anoxybiotic ability (P＜0.01) under the mice tolerance normal pressure, prolongs the anoxia tolerance time (P＜0.01) that sodium nitrite poisons and causes, this shows that this product has the health care of anoxia enduring.
The preparation instantiation
Embodiment 1
With Radix Ginseng Rubra 20g, Radix Salviae Miltiorrhizae 50g, Herba Epimedii 40g, Cortex Cinnamomi 15g and Radix Ophiopogonis 35g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 6 times of water gagings immersion 6h, kept the slight boiling condition reflux, extract, 8 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 2h of 10 times of amounts 60%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 70 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.25 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 2%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 2h, hide 24h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 2
With Radix Ginseng Rubra 10g, Radix Salviae Miltiorrhizae 40g, Herba Epimedii 30g, Cortex Cinnamomi 10g and Radix Ophiopogonis 30g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 5 times of water gagings immersion 4h, kept the slight boiling condition reflux, extract, 6 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 1h of 8 times of amounts 50%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 60 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.2 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 3%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 1h, hide 20h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 3
With Radix Ginseng Rubra 20g, Radix Salviae Miltiorrhizae 50g, Herba Epimedii 40g, Cortex Cinnamomi 15g and Radix Ophiopogonis 35g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 5 times of water gagings immersion 4h, kept the slight boiling condition reflux, extract, 6 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 1h of 8 times of amounts 50%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 60 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.2 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 1%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 1h, hide 20h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 4
With Radix Ginseng Rubra 30g, Radix Salviae Miltiorrhizae 60g, Herba Epimedii 50g, Cortex Cinnamomi 20g and Radix Ophiopogonis 40g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 8 times of water gagings immersion 8h, kept the slight boiling condition reflux, extract, 10 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 3h of 12 times of amounts 70%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 80 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.25 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 1.5%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 3h, hide 30h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 5
With Radix Ginseng Rubra 20g, Radix Salviae Miltiorrhizae 50g, Herba Epimedii 40g, Cortex Cinnamomi 15g and Radix Ophiopogonis 35g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 8 times of water gagings immersion 8h, kept the slight boiling condition reflux, extract, 10 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 3h of 12 times of amounts 70%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 80 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.25 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 2.5%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 3h, hide 30h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 6
With Radix Ginseng Rubra 15g, Radix Salviae Miltiorrhizae 45g, Herba Epimedii 35g, Cortex Cinnamomi 15g and Radix Ophiopogonis 35g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 7 times of water gagings immersion 7h, kept the slight boiling condition reflux, extract, 9 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 1.5h of 9 times of amounts 55%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 65 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.21 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 3.5%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 1.5h, hide 25h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 7
With Radix Ginseng Rubra 25g, Radix Salviae Miltiorrhizae 50g, Herba Epimedii 40g, Cortex Cinnamomi 15g and Radix Ophiopogonis 40g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 6 times of water gagings immersion 5h, kept the slight boiling condition reflux, extract, 8 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 2.5h of 11 times of amounts 65%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; 75 ℃ of decompression recycling ethanols of merge extractive liquid, are not to there being the alcohol flavor, continue to be concentrated into relative density and be 1.24 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 2.8%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 2.5h, hide 25h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Embodiment 8
With Radix Ginseng Rubra 30g, Radix Salviae Miltiorrhizae 40g, Herba Epimedii 50g, Cortex Cinnamomi 10g and Radix Ophiopogonis 30g be ground into granule less than 4mm, wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 6 times of water gagings immersion 8h, kept the slight boiling condition reflux, extract, 10 hours, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 3h of 8 times of amounts 60%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; Merge extractive liquid, 60-80 ℃ decompression recycling ethanol is not to there being the alcohol flavor, continues to be concentrated into relative density and be 1.23 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions, and vacuum 0.10MPa drying under reduced pressure to moisture is 4%, pulverizes, and crosses 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 3h, hide 30h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
Claims (5)
1. granule of treating anoxia enduring is characterized in that granule of the present invention is made up of Radix Ginseng Rubra, Herba Epimedii, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Cortex Cinnamomi Chinese medicine of the five flavours.
2. a kind of granule of treating anoxia enduring as claimed in claim 1 is characterized in that granule prescription amount ranges of the present invention is: Radix Ginseng Rubra 10-30g, Radix Salviae Miltiorrhizae 40-60g, Herba Epimedii 30-50g, Cortex Cinnamomi 10-20g, Radix Ophiopogonis 30-40g.
3. a kind of granule of treating anoxia enduring as claimed in claim 1 is characterized in that granule prescription optimum amount of the present invention is: Radix Ginseng Rubra 20g, Radix Salviae Miltiorrhizae 50g, Herba Epimedii 40g, Cortex Cinnamomi 15g, Radix Ophiopogonis 35g.
4. a kind of granule of treating anoxia enduring as claimed in claim 1 is characterized in that this process for producing granula comprises the steps:
Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Cortex Cinnamomi and Radix Ophiopogonis powder are broken into the granule less than 4mm, and wherein Cortex Cinnamomi is pulverized the back and crosses 10 mesh sieves; Take by weighing Cortex Cinnamomi and add 5-8 times of water gaging immersion 4-8h, kept the slight boiling condition reflux, extract, 6-10 hour, collect volatile oil and recording volume, subsequent use; Cortex Cinnamomi volatile oil is extracted back gained filtrating preserve, subsequent use; Filtering residue and Radix Ginseng Rubra, Radix Salviae Miltiorrhizae, Herba Epimedii, Radix Ophiopogonis, mix homogeneously added the alcohol reflux 1-3h that 8-12 doubly measures 50-70%, crossed and filtered extracting solution 1; Filtering residue extracts 2 times with method; Filtration obtains extracting solution 2, extracting solution 3, merges filtrating and extracting solution 1,2,3 that volatile oil extracts, stand for standby use; Merge extractive liquid, 60-80 ℃ decompression recycling ethanol is not to there being the alcohol flavor, continues to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution, 70 ℃ of mixed extraction concentrated solutions; Vacuum 0.10MPa drying under reduced pressure to moisture is below 5%; Pulverize, cross 40 mesh sieves, fine powder is subsequent use; According to volatile oil and beta-schardinger dextrin-ratio is 1ml: 6g takes by weighing beta-schardinger dextrin-, is dissolved in the hot water of 10 times of volumes, and 70 ℃ of constant temperature stir, and get settled solution; Volatile oil is dissolved in the dehydrated alcohol of 4 times of volumes; Under continuing stirring, the volatile oil alcoholic solution is slowly dropped in the cyclodextrin solution, continue to stir 1-3h, hide 20-30h in refrigerator and cooled; Sucking filtration; With low amounts of water and absolute ethanol washing filter cake, filter cake is in the Benexate Hydrochloride of the Cortex Cinnamomi volatile oil of 40 ℃ of oven dry, and is subsequent use; Said extracted thing dry powder and Benexate Hydrochloride according to the equivalent method mix homogeneously that progressively increases, are measured the content of Radix Ginseng total saponins in the intermediate, then with this mixture with etc. the dextrin mix homogeneously of quality; With the orange flavor of the aspartame of the extract dry powder that mixes and Benexate Hydrochloride and 0.1% and 0.5% with the equivalent method mix homogeneously that progressively increases; With the extract dry powder that mixes and Benexate Hydrochloride with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate promptly get granule of the present invention after 50 ℃ of oven dry.
5. a kind of granule of treating anoxia enduring as claimed in claim 1 is characterized in that this granule is mainly used in the treatment of anoxia enduring.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017185280A1 (en) * | 2016-04-28 | 2017-11-02 | 金英花 | Biological compound preparation which can improve altitude hypoxia tolerance and preparation method thereof |
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| 丁媛媛等: "肉桂油治疗小鼠CVB3m 病毒性心肌炎的实验研究", 《第四军医大学学报》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017185280A1 (en) * | 2016-04-28 | 2017-11-02 | 金英花 | Biological compound preparation which can improve altitude hypoxia tolerance and preparation method thereof |
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