CN101411759B - Capsule for preventing altitude stress as well as preparation method and application thereof - Google Patents
Capsule for preventing altitude stress as well as preparation method and application thereof Download PDFInfo
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- CN101411759B CN101411759B CN2008101660681A CN200810166068A CN101411759B CN 101411759 B CN101411759 B CN 101411759B CN 2008101660681 A CN2008101660681 A CN 2008101660681A CN 200810166068 A CN200810166068 A CN 200810166068A CN 101411759 B CN101411759 B CN 101411759B
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Abstract
The invention relates to a capsule health care product by taking plateau Malus toringoides as a main raw material, which has special efficacies of anoxia resistance, fatigue resistance and prevention of altitude stress. Plateau Malus toringoides extract is used as the raw material of the capsule health care product for anoxia resistance, fatigue resistance and prevention of altitude stress for the first time.
Description
Technical field
The present invention relates to a kind of anoxia enduring, antifatigue has the capsule of prevention altitude sickness function, and particularly relating to a kind of is the capsule with prevention altitude sickness function that raw material is processed with natural wild plateau plant.
Background technology
Acute high altitude reaction (acute high altitude response) is meant when human body gets into the higher area of height above sea level by entering plateau, Plain or by the plateau in the short time (referring to area more than 3000m); Because adaptation mechanism is not set up as yet, body is at short notice because of being in a series of clinical syndromes that hypobaric hypoxia environment takes place.Generally behind 3～10 days plateau living accommodations, symptom alleviates gradually or disappears.The hypobaric hypoxia environment on plateau is to cause the main cause of falling ill, and common risk factor has: to the psychological hypertonicity of altitude environment, upper respiratory tract infection, fatigue, hunger, fear, do not have enough sleep and smoking etc.Clinical manifestation is headache, giddy, cyanosis, heart rate quickening, gastrointestinal symptom, water-sodium retention and alkalemia etc., and at present mostly Therapeutic Method is psychotherapy and Drug therapy, can obey 1～2 of somedon, C. P. P. C/inferior, every day 2 times like headache, dizzy person.The insomniac can obey tranquilizer such as chlordiazepoxide, phenobarbital class, can alleviate headache, but should note avoiding causing the untoward reaction that suppresses breathing, especially at Ying Shenyong at night.Severe headache, the obvious person of cyanosis can try out low molecular dextran 250ml intravenous drip, every day 1 time.But and acupuncture point such as acupuncture sun, connected valleys, Baihui.Cardiopalmus, tachycardia person can take stable 2.5mg, 2 times on the 1st; ATP40mg, 3 times on the 1st.Oxygen uptake can be removed serious headache, but the oxygen uptake of discontinuity a small amount of might delay the procedure of adaptation of body to the plateau.Suitably replenishing potassium salt, possibly be a factor of acute high altitude reaction because of potassium deficiency.Meet emergency, can use the dexamethasone initial dose to be 8mg, later per 6 hours 4mg can obviously alleviate the acute mountain sickness symptom.To hypourocrinia, edema person can take aminophylline 0.1～0.2g, every day 3 times; Or use spironolactone 20mg, every day 3 times; Hydrochlorothiazide 25mg every day 2 times; (the obvious person of diuresis should note kalium replenishment).The obvious person of edema also can obey furosemide 20mg, every day 2 times.For severe patient such as severe headache, frequent, the intracranial hypertension person of vomiting, except that being interrupted oxygen uptake, can give 20% mannitol, 125～250ml intravenous drip.Multiple metabolite and medicine were carried out Prevention Research both at home and abroad, like vitamins: vitamin B1, B2, C, E, nicotinic acid and amide etc.; Biological preparation: cytochrome C, codecarboxylase, ATP, DPN, heparin etc.; Nutrient substance: sugar, aminoacid, protein, carotene, ferrum, potassium, calcium; Medicine: High Energy Mixture, aminophylline, the spirit of sharp oxygen, aldactone, bendazol, persantin etc.; The material of abnormal metabolism when correcting the body anoxia: like carbon dioxide, methylene blue, ammonium chloride etc.Domestic is main with Chinese herbal medicine to the research of altitude sickness prophylactic agent over nearly 30 years mostly, especially adopts highlands particularly Tibetan medicine such as Radix Ginseng, Radix Codonopsis, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae, Rhodiola kirilowii (Regel) Maxim., dracocephalum heterophyllum, plateau Brassica campestris L pollen, Semen Ziziphi Spinosae total saponins, Fructus Lycii, Fructus Hippophae, Radix Salviae Miltiorrhizae, compound Codonopsis pilosula, Radix Astragali Poria compound recipe, ginseng stilbene pollen compound recipe and many ginseng peaceful sheets of high mountain (anti-hypoxia sheet) etc. in the area, Qinghai-Tibet.Because adopt the chemicals toxic and side effects big, Chinese medicine still can not satisfy clinical needs owing to have nothing in common with each other to mechanism.
Malus toringoides (Rehd.) Hughes (Malus toringoides (Rehd.) Hughes) (another name: the DABAI Herba Bulbophylli radiati) be Angiospermae (ANGIOSPERMAE); Dicotyledoneae (DICOTYLEDONAE); Rosaceae (Rosaceae), Fructus Mali pumilae subfamily (Maloideae Weber), Malus (Malus); Fructus Sorbi Pohuashanensis Fructus Mali pumilae group (Sect.Sorbomalus Zabel), Malus kansuensis (Batal.) Schneid. system (Ser.Kansuenses) plant.Produce the southeast, Gansu, western Sichuan and the southeast, Tibet.In the jungle of hillside, 2000-3800 meters of height above sea level.
The ecological environment of the morphological characteristic of Malus toringoides (Rehd.) Hughes (Malus toringoides (Rehd.) Hughes), germplasm characteristic (salt tolerant, drought-enduring, heat-resisting, cold-resistant, waterlogging, anti-canker and root rot etc.), distribution etc. all has extremely complicated multiformity.Malus toringoides (Rehd.) Hughes is done the apple rootstock utilization, has merits such as strong stress resistance, half dwarfing, precocity fruiting, high yield and raising fruit quality, is extremely important germ plasm resource.Research to Malus toringoides (Rehd.) Hughes at present focuses mostly on aspect its form multiformity and the growing and cultivation; As: Liao Feixiong, Li Yunong, Agricultural University Of Southwest's journal is observed in the aposporous fetology of Malus toringoides (Rehd.) Hughes (Malus toringoides (Rehd.) Hughes); In April, 1997, the 19th the 2nd phase of volume; Liao Feixiong, Li Yunong, the characteristic and the result of Malus toringoides (Rehd.) Hughes (M.toringoides (Rehd.) Hughfes) apomixis fetal development, Agricultural University Of Jiangxi's journal, the 18th the 3rd phase of volume, in JIUYUE, 1996; Expensive, the Cheng Minghao of Zhang Yun becomes the preliminary study that leaf slide Chinese bush cherry variation class is moulded, 1998 the 3rd phases of southwestern gardening; Deng Hongping, Cheng Minghao, Chen Yafei, Huang Lin, the research of form multiformity differentiation and the Malus kansuensis (Batal.) Schneid. relation of Malus toringoides (Rehd.) Hughes variation type, southwestern pedagogical Imperial College journal (natural science edition), the 27th volume, the 1st phase; Cheng Minghao, Li Xiaolin, Wang Mei, Ceng Weiguang, Wu Fushou, golden strong, the research of Malus toringoides (Rehd.) Hughes variation type, gardening journal, 1992,19 (3); 233-239; Malus toringoides (Rehd.) Hughes seedling growth test preliminary study, in the forestry bureau Malaysian of Luhuo, Ganzi science and technology, 22 phases; Yang Ping, Dai Xuedong, Liu Dajian, Malus toringoides (Rehd.) Hughes grow seedlings and afforestation technology, forestry practical technique, 2006 the 9th phases; The stone good friends, Cheng Minghao, Liang Guolu, the good rootstock resource of Fructus Mali pumilae--Malus toringoides (Rehd.) Hughes, Agricultural University Of Southwest's journal (natural science edition), the 26th the 1st phase of volume, in February, 2004.But Malus toringoides (Rehd.) Hughes is used for food, is prepared into the product of health-care efficacy, still do not have the pertinent literature report.
Summary of the invention
The invention provides a kind of capsule of effective prevention altitude sickness, it is to be the capsule that feedstock production forms by Malus toringoides (Rehd.) Hughes Malus toringoides (Rehd.) Hughes.The present invention also provides the method for preparing of this capsule.
The invention provides a kind of capsule that prevents altitude sickness, it is to be the capsule that feedstock production forms by Malus toringoides (Rehd.) Hughes Malustoringoides (Rehd.) Hughes, contains Malus toringoides (Rehd.) Hughes protophyte 0.5～10g in wherein every capsules.
Wherein, described raw material is leaves, root, skin, stem or the fruit of Malus toringoides (Rehd.) Hughes.
It is to be active component by the water of the leaves of Malus toringoides (Rehd.) Hughes, root, skin, stem or fruit or extractive with organic solvent, adds the capsule that acceptable auxiliary or complementary composition are prepared into.
Wherein, also contain green tea in the described raw material, wherein the weight proportion of raw material Malus toringoides (Rehd.) Hughes and green tea is:
10～90 parts of Malus toringoides (Rehd.) Hughes, 90～10 parts of green tea.
Further preferably, the weight proportion of Malus toringoides (Rehd.) Hughes and green tea is:
40～80 parts of Malus toringoides (Rehd.) Hughes, 20～60 parts of green tea.
Wherein, also contain black tea in the described raw material, wherein the weight proportion of raw material Malus toringoides (Rehd.) Hughes and black tea is:
10～90 parts of Malus toringoides (Rehd.) Hughes, 90～10 parts of black tea.
Further preferably, the weight proportion of Malus toringoides (Rehd.) Hughes and black tea is:
40～80 parts of Malus toringoides (Rehd.) Hughes, 20～60 parts of black tea.
Wherein, also contain black tea and green tea in the described raw material, wherein, the weight proportion of raw material Malus toringoides (Rehd.) Hughes and black tea, green tea is:
40～80 parts of Malus toringoides (Rehd.) Hughes, 20～60 parts of black tea, 20～60 parts of green tea.
The present invention also provides the method for preparing of this capsule, comprises the steps:
Get Malus toringoides (Rehd.) Hughes, extract, extracting solution concentrates; The concentrated solution precipitated impurities, solution absorbs, eluting, eluent recovery solvent get solution and place crystallize, drying, get the raw material finished product, add adjuvant filler filling, encapsulated, get capsule.
Wherein extracting solvent can be water; Also can be organic solvent, as alcohols or contain alcohol mixture, wherein alcohols is preferably ethanol and methanol.Extracting solvent can be water; Also can be organic solvent, as alcohols or contain alcohol mixture, wherein alcohols is preferably ethanol and methanol.
The present invention also provides this capsule to have anoxia enduring in preparation, and antifatigue has the purposes in the health product that prevent altitude sickness.
Health product of the present invention are the All Pure Nature plateau plant, and toxic and side effects is low, have reached the effect and the requirement of health food, are used to prevent altitude sickness that a kind of new selection is provided for clinical.
Below through the specific embodiment the present invention is made further detailed description; But do not limit the present invention; Those skilled in the art can make various changes and distortion according to the present invention, only otherwise break away from spirit of the present invention, all should belong to the scope of accompanying claims of the present invention.
The specific embodiment
The preparation of embodiment 1 capsule of the present invention
Getting Malus toringoides (Rehd.) Hughes is raw material, gets crude drug in whole 1000g, adds 10 times of water gagings after the coarse crushing, and heating and refluxing extraction 3 hours is filtered, and filtering residue was respectively 2 hours and 1 hour with 8 times and 6 times of water reheat reflux, extract, twice at every turn.Filter.Merge filtrating three times, concentrated, refining, drying gets the raw material finished product, adds adjuvant filler filling, encapsulated, gets capsule.
Specification: the active substance that contains in every capsules is equivalent to Malus toringoides (Rehd.) Hughes protophyte 0.5～10g.
The preparation of embodiment 2 capsules of the present invention
Adopt the method for distilling of embodiment 1 Malus toringoides (Rehd.) Hughes to prepare the Malus toringoides (Rehd.) Hughes extract, subsequent use;
Preparation green tea extract method: get green tea 1000g, add 10 times of water gagings after the coarse crushing, heating and refluxing extraction 3 hours is filtered, and filtering residue was respectively 2 hours and 1 hour with 8 times and 6 times of water reheat reflux, extract, twice at every turn.Filter.Merge filtrating three times, concentrate, concentrated solution adds adjuvant and mixes, and granulates, and drying obtains green tea extract.
With two kinds of extracts in following ratio compatibility, the fill capsule, sterilize finished product.
Table 1 Malus toringoides (Rehd.) Hughes and green tea proportioning
| Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8 | |
| Malus toringoides (Rehd.) Hughes | 90kg | 90kg | 90kg | 10kg | 80kg | 80kg | 40kg | 40kg |
| Green tea | 0kg | 90kg | 10kg | 90kg | 60kg | 20kg | 60kg | 20kg |
The preparation of embodiment 3 capsules of the present invention
Adopt the method for distilling of embodiment 1 Malus toringoides (Rehd.) Hughes to prepare the Malus toringoides (Rehd.) Hughes extract, subsequent use;
Preparation black tea extract method: get black tea 1000g, add 10 times of water gagings after the coarse crushing, heating and refluxing extraction 3 hours is filtered, and filtering residue was respectively 2 hours and 1 hour with 8 times and 6 times of water reheat reflux, extract, twice at every turn.Filter.Merge filtrating three times, concentrate, concentrated solution adds adjuvant and mixes, and granulates, and drying obtains black tea extract.
With above-mentioned two kinds of extracts in following ratio compatibility, the fill capsule, sterilize finished product.
The proportioning of table 2 Malus toringoides (Rehd.) Hughes tea and black tea
| Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8 | |
| Malus toringoides (Rehd.) Hughes | 90kg | 90kg | 90kg | 10kg | 80kg | 80kg | 40kg | 40kg |
| Black tea | 0kg | 90kg | 10kg | 90kg | 60kg | 20kg | 60kg | 20kg |
The preparation of embodiment 4 capsules of the present invention
Adopt the method for distilling of embodiment 1 Malus toringoides (Rehd.) Hughes to prepare the Malus toringoides (Rehd.) Hughes extract, subsequent use;
Preparation green tea or black tea extract method: get green tea or black tea 1000g, add 10 times of water gagings after the coarse crushing, heating and refluxing extraction 3 hours is filtered, and filtering residue was respectively 2 hours and 1 hour with 8 times and 6 times of water reheat reflux, extract, twice at every turn.Filter.Merge filtrating three times, concentrate, concentrated solution adds adjuvant and mixes, and granulates, and drying obtains green tea or black tea extract.
With above-mentioned three kinds of extracts in following ratio compatibility, the fill capsule, sterilize finished product.
The proportioning of table 3 Malus toringoides (Rehd.) Hughes tea and green tea, black tea
| Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | |
| Malus toringoides (Rehd.) Hughes | 80kg | 80kg | 80kg | 40kg | 40kg | 80kg | 40kg |
| Black tea | 60kg | 20kg | 60kg | 20kg | 60kg | 20kg | 20kg |
| Green tea | 60kg | 60kg | 20kg | 60kg | 20kg | 20kg | 20kg |
The specification of the capsule of above-mentioned preparation is: contain active substance in every capsules and be equivalent to Malus toringoides (Rehd.) Hughes protophyte 0.5～10g.
Below through Ergonomy evidence beneficial effect of the present invention.
Test Example 1 Ergonomy test of the present invention
(1) normal pressure anoxia enduring experiment:
1 materials and methods
1.1 reagent and instrument
Capsule of the present invention is by the method preparation of embodiment 1.Sodica calx, electronic balance, electronic stopclock, constant temperature swimming case, shears, tweezers and chopper etc.
1.2 laboratory animal
40 of ICR mices, body weight 18～22g, Chinese Academy of Sciences's Shanghai Experimental Animal Center provides, and animal housing's temperature is controlled at 20 ℃～25 ℃, and relative humidity is 45%～55%, is 12h/12h round the clock, freely takes the photograph water and diet.
1.3 test method
1.3.1 dosage setting
3 test group and 1 negative control group are established in each experiment in the experiment, 10 of every group of mices.The dosage of 3 test group Radix Rhodiolaes is respectively 0.22,0.45 and 1.35g/kg, and negative control group gives distilled water.Test each group for 4 and irritate stomaches to sample, every day 1 time, continuous 30d, irritating the stomach volume is the 0.1ml/10g body weight.
1.3.2 the normal pressure anoxia enduring is tested 1h after last gives sample, and each group mice is put respectively in the 250ml port grinding bottle that the people fills the 5g sodica calx (1 every bottle), seal, and be dead indication with respiratory arrest, observe the mice time-to-live.
2 results
Table 1 health product capsule of the present invention is to the mice normal pressure influence of anoxia enduring time-to-live (i ± s)
Visible by table 1, tried the basic, normal, high three dose groups normal pressure anoxia enduring time-to-live of thing and compared with negative control group, significant difference (P>0.05) is all arranged.
(2) sodium nitrite poisoning survival experiment: sodium nitrite makes normal ferrous iron hemoglobin change the ferric iron hemoglobin into, destroys the hemoglobin oxygen carrying capacity, causes histanoxia dead.1h after last is irritated stomach, each treated animal lumbar injection sodium nitrite 200～240mg/kg (injection volume is 0.1mg/10g), timing immediately, record animals survived time.
Above-mentioned two experimental datas adopt variance analysis and Q check carrying out statistical analysis.Tried the thing group time-to-live than matched group significant prolongation, experimental result is judged to be the positive.
(3) acute cerebral ischemia property anoxia experiment: behind the animal broken end; Because cerebral blood supply stops, original blood and nutrient substance still can make brain function keep blink in the brain at short notice, demonstrate and clocklike dehisce to breathe; With the time of breathing be index; Can observe and tried thing to the anoxybiotic protective effect of cerebral ischemia, all things that tried that can make the reduction of brain oxygen consumption all can prolong animal and breathe the time.1h after last is irritated stomach, each treated animal (under the ether light anaesthesia) from cervical region by broken end only, immediately by behind the stopwatch record mice broken end to the dwell time of breathing of dehiscing.
Adopt variance analysis and Q check carrying out statistical analysis.Tried the thing group time ratio matched group significant prolongation of breathing, experimental result is judged to be the positive.
Evidence, health product of the present invention are directed against anoxia enduring, resisting fatigue, effect is obvious.
Claims (10)
1. a capsule that prevents altitude sickness is characterized in that, it is the capsule that is formed by the feedstock production that contains Malus toringoides (Rehd.) Hughes Malustoringoides (Rehd.) Hughes, contains Malus toringoides (Rehd.) Hughes in wherein every capsules, in protophyte 0.5-10g.
2. the capsule of prevention altitude sickness according to claim 1; It is characterized in that; It is by the protophyte that contains the raw material Malus toringoides (Rehd.) Hughes; The perhaps water extract of raw material Malus toringoides (Rehd.) Hughes, perhaps the extractive with organic solvent of raw material Malus toringoides (Rehd.) Hughes is an active component, adds the capsule that acceptable auxiliary or complementary composition are prepared into.
3. the capsule of prevention altitude sickness according to claim 1 and 2 is characterized in that, described raw material is leaves, root, skin, stem or the fruit of Malus toringoides (Rehd.) Hughes.
4. the capsule of prevention altitude sickness according to claim 1 and 2 is characterized in that, also contains green tea in the described raw material, and wherein the weight proportion of raw material Malus toringoides (Rehd.) Hughes and green tea is:
10～90 parts of Malus toringoides (Rehd.) Hughes, 90～10 parts of green tea.
5. the capsule of prevention altitude sickness according to claim 4 is characterized in that: the weight proportion of Malus toringoides (Rehd.) Hughes and green tea is:
40～80 parts of Malus toringoides (Rehd.) Hughes, 20～60 parts of green tea.
6. the capsule of prevention altitude sickness according to claim 1 and 2 is characterized in that: also contain black tea in the described raw material, wherein the weight proportion of raw material Malus toringoides (Rehd.) Hughes and black tea is:
10～90 parts of Malus toringoides (Rehd.) Hughes, 90～10 parts of black tea.
7. the capsule of prevention altitude sickness according to claim 6 is characterized in that: the weight proportion of Malus toringoides (Rehd.) Hughes and black tea is:
40～80 parts of Malus toringoides (Rehd.) Hughes, 20～60 parts of black tea.
8. the capsule of prevention altitude sickness according to claim 1 and 2 is characterized in that: described raw material is made up of Malus toringoides (Rehd.) Hughes, black tea and green tea, and wherein, the weight proportion of raw material Malus toringoides (Rehd.) Hughes and black tea, green tea is:
40～80 parts of Malus toringoides (Rehd.) Hughes, 20～60 parts of black tea, 20～60 parts of green tea.
9. a method for preparing the capsule of the described prevention altitude sickness of claim 1 comprises the steps:
Get Malus toringoides (Rehd.) Hughes, extract, extracting solution concentrates; The concentrated solution precipitated impurities, solution absorbs, eluting, eluent recovery solvent get solution and place crystallize, drying, get the raw material finished product, add adjuvant filler filling, encapsulated, get capsule.
10. the described capsule of claim 1 has anoxia enduring in preparation, the purposes in the health product of antifatigue prevention altitude sickness.
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| CN101411761A (en) * | 2007-10-17 | 2009-04-22 | 毛羽 | Novel use of plants in sorbus malus group of malus |
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|---|---|---|---|---|
| CN1351839A (en) * | 2000-11-09 | 2002-06-05 | 李绪荣 | Hubei Haitang red tea drink and producing method |
| CN101411761A (en) * | 2007-10-17 | 2009-04-22 | 毛羽 | Novel use of plants in sorbus malus group of malus |
| CN101411760A (en) * | 2007-10-17 | 2009-04-22 | 毛羽 | Novel use of plants in sorbus malus group of malus |
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| Stushnoff C 等.Diversity of phenolic antioxidant content and radical scavenging capacity in the USDA apple germplasm core collection.《PLANT GENETIC RESOURCES》.2003,(第623期),305-311. * |
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