CN102576012B - 用于肾损伤和肾衰竭的诊断及预后方法和组合物 - Google Patents

用于肾损伤和肾衰竭的诊断及预后方法和组合物 Download PDF

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Publication number
CN102576012B
CN102576012B CN201080043037.2A CN201080043037A CN102576012B CN 102576012 B CN102576012 B CN 102576012B CN 201080043037 A CN201080043037 A CN 201080043037A CN 102576012 B CN102576012 B CN 102576012B
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Chinese (zh)
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CN102576012A (zh
Inventor
J·安德贝里
J·格雷
P·麦克弗森
K·中村
J·P·坎普夫
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Astute Medical Inc
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Astute Medical Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7452—Thrombomodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201080043037.2A 2009-09-18 2010-09-17 用于肾损伤和肾衰竭的诊断及预后方法和组合物 Expired - Fee Related CN102576012B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510401130.0A CN105004864B (zh) 2009-09-18 2010-09-17 用于肾损伤和肾衰竭的诊断及预后方法和组合物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US24400009P 2009-09-18 2009-09-18
US24399509P 2009-09-18 2009-09-18
US61/243,995 2009-09-18
US61/244,000 2009-09-18
US25463609P 2009-10-23 2009-10-23
US61/254,636 2009-10-23
PCT/US2010/049234 WO2011035097A1 (en) 2009-09-18 2010-09-17 Methods and composition for diagnosis and prognosis of renal injury and renal failure

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510401130.0A Division CN105004864B (zh) 2009-09-18 2010-09-17 用于肾损伤和肾衰竭的诊断及预后方法和组合物

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CN102576012A CN102576012A (zh) 2012-07-11
CN102576012B true CN102576012B (zh) 2015-07-15

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CN201510401130.0A Expired - Fee Related CN105004864B (zh) 2009-09-18 2010-09-17 用于肾损伤和肾衰竭的诊断及预后方法和组合物

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Country Status (10)

Country Link
US (2) US20130045494A1 (enExample)
EP (2) EP3299821A1 (enExample)
JP (3) JP2013513086A (enExample)
CN (2) CN102576012B (enExample)
AU (2) AU2010295512B2 (enExample)
CA (1) CA2773905A1 (enExample)
EA (1) EA201290106A1 (enExample)
MX (1) MX2012003168A (enExample)
NZ (2) NZ598741A (enExample)
WO (1) WO2011035097A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012312907A1 (en) * 2011-08-26 2014-03-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP6532460B2 (ja) * 2013-07-26 2019-06-19 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 患者モニタリングシステムに関する臨床規則及び規定のコンピュータ化及び視覚化
GB201501597D0 (en) * 2015-01-30 2015-03-18 Randox Lab Ltd Thrombomodulin
CN108271422A (zh) 2015-06-25 2018-07-10 株式会社国际电气通信基础技术研究所 基于器官间串扰系统的预测装置及预测程序
WO2017130985A1 (ja) * 2016-01-29 2017-08-03 株式会社国際電気通信基礎技術研究所 腎機能の評価装置、腎疾患の合併症の発症の予測装置、およびリン摂取量推定装置
EP3438282A4 (en) 2016-03-29 2020-05-06 Advanced Telecommunications Research Institute International METHOD FOR SCREENING CANDIDATE SUBSTANCES FOR AN ACTIVE COMPONENT TO PREVENT OR TREAT AT LEAST ONE SELECTED DISEASE IN THE KIDNEY HYPOFUNCTION GROUP, CHRONIC KIDNEY DISEASE AND KIDNEY DEFICIENCY
CN114778845A (zh) 2016-03-29 2022-07-22 无限生物制药公司 药物组合物或食品组合物及评价活性成分体内效果的方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
JPH0736019B2 (ja) * 1989-12-27 1995-04-19 富士薬品工業株式会社 新規な抗ヒトトロンボモジュリンモノクローナル抗体によるヒトトロンボモジュリンおよびその分解産物の定量方法
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
WO1992005282A1 (en) 1990-09-14 1992-04-02 Biosite Diagnostics, Inc. Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
CA2107899A1 (en) 1991-04-10 1992-10-11 Gunars Edwin Valkirs Novel conjugates and assays for simultaneous detection of multiple ligands
FI934437L (fi) 1991-04-10 1993-11-22 Biosite Diagnostics Inc Crosstalk-inhibitorer och deras anvaendning
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US6544761B2 (en) * 1994-12-13 2003-04-08 Human Genome Sciences, Inc. Human tissue inhibitor of metalloproteinase-4
CN1129666C (zh) * 1994-12-13 2003-12-03 人体基因组科学有限公司 金属蛋白酶－4的人组织抑制剂
CN1495258A (zh) * 1994-12-13 2004-05-12 人体基因组科学有限公司 金属蛋白酶-4的人组织抑制剂
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
AU2094101A (en) * 1999-12-13 2001-06-18 Duanqing Pei Leukolysin/mmp25/mt6-mmp
EP2336368A1 (en) * 2000-12-07 2011-06-22 Novartis Vaccines and Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
JP4179988B2 (ja) * 2001-07-12 2008-11-12 協和メデックス株式会社 変性リポ蛋白質の定量法、変性リポ蛋白質の定量用試薬、循環器疾患の検出方法および循環器疾患の検出試薬
EP1742650A1 (en) * 2004-03-30 2007-01-17 Den Kgl.Veterin R-Og Landboh Jskole Improvements in cancer treatment and cancer treatment efficacy prediction by blocking and detecting protease inhibitors
US7713693B1 (en) * 2004-09-01 2010-05-11 University Of Louisiana At Monroe Human cancer cell specific gene transcript
US20060160112A1 (en) * 2004-12-02 2006-07-20 Erdal Cavusoglu Tissue inhibitor of metalloproteinase (TIMP) as a marker and predictor of cardiovascular disease and both cardiac and non-cardiac mortality
US20090178145A1 (en) * 2005-05-11 2009-07-09 The Procter & Gamble Company Methods and targets for identifying compounds for regulating angiogenesis
WO2007053610A2 (en) * 2005-11-01 2007-05-10 The Regents Of The University Of California Methods of treating atrial fibrillation wtih pirfenidone
JP2007163151A (ja) * 2005-12-09 2007-06-28 Kitasato Gakuen 対象生物の生理状態を判定する方法
MX2008014155A (es) * 2006-05-09 2009-02-25 Musc Found For Res Dev Deteccion de insuficiencia cardiaca diastolica por proteasa y determinacion de perfil plasmatico de inhibidor de proteasa.
CN101490273A (zh) * 2006-05-09 2009-07-22 南卡罗来纳州医科大学研究发展基金会 利用蛋白酶和蛋白酶抑制剂血浆分析检测舒张期心力衰竭
WO2008084331A2 (en) * 2006-06-21 2008-07-17 Hopitaux Universitaires De Geneve Biomarkers for renal disorders
CA2657249A1 (en) * 2006-07-11 2008-01-17 Musc Foundation For Research Development Predicting heart failure following myocardial infarction by protease and protease inhibitor profiling
GB0617429D0 (en) * 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
WO2008060607A2 (en) * 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
FR2909180B1 (fr) * 2006-11-29 2009-02-20 Diagnostica Stago Soc Par Acti Methode de mesure fonctionnelle de l'activite de la thrombomoduline plasmatique.

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IgA-containing immune complexes in the urine of IgA nephropathy patients;Karel Matousovic et al.;《Nephrology Dialysis Transplantation》;20060930;第21卷(第9期);第2478-2484页 *
Predicting renal outcome in IgA nephropathy;RADFORD et al.;《Journal of the American Society of Nephrology》;19970228;第8卷(第2期);第199-207页 *
The level of urinary secretory immunoglobulin A(sIgA) of patients with IgA nephropathy is elevated and associated with pathological phenotypes;Y.Tan等;《Clinical and Experimental Immunology》;20090430;第156卷(第1期);第111-116页 *

Also Published As

Publication number Publication date
HK1212774A1 (zh) 2016-06-17
CA2773905A1 (en) 2011-03-24
EP3299821A1 (en) 2018-03-28
EP2470904A1 (en) 2012-07-04
EP2470904A4 (en) 2013-05-01
CN102576012A (zh) 2012-07-11
AU2010295512B2 (en) 2014-12-18
JP2015129764A (ja) 2015-07-16
CN105004864A (zh) 2015-10-28
AU2010295512A1 (en) 2012-04-05
US20130045494A1 (en) 2013-02-21
HK1167889A1 (zh) 2012-12-14
NZ598741A (en) 2013-07-26
WO2011035097A1 (en) 2011-03-24
JP6403712B2 (ja) 2018-10-10
JP2016176953A (ja) 2016-10-06
NZ612673A (en) 2014-10-31
AU2015200953A1 (en) 2015-03-12
CN105004864B (zh) 2017-11-03
MX2012003168A (es) 2012-05-08
US20190250170A1 (en) 2019-08-15
EA201290106A1 (ru) 2012-12-28
JP2013513086A (ja) 2013-04-18

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