CN102573993A - 治疗炎症的化合物 - Google Patents

治疗炎症的化合物 Download PDF

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Publication number
CN102573993A
CN102573993A CN2010800325573A CN201080032557A CN102573993A CN 102573993 A CN102573993 A CN 102573993A CN 2010800325573 A CN2010800325573 A CN 2010800325573A CN 201080032557 A CN201080032557 A CN 201080032557A CN 102573993 A CN102573993 A CN 102573993A
Authority
CN
China
Prior art keywords
inflammation
pharmaceutical composition
pharmaceutically acceptable
receptor
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800325573A
Other languages
English (en)
Chinese (zh)
Inventor
N·帕尔姆奎斯特
A·斯尤丁
C·温戈伦
C·弗鲁德
L·伦德伯格
E·塞弗特
P·勒克
A·波曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anamar AB
Original Assignee
Anamar AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0913427A external-priority patent/GB0913427D0/en
Priority claimed from GBGB1005495.5A external-priority patent/GB201005495D0/en
Priority claimed from GBGB1010671.4A external-priority patent/GB201010671D0/en
Application filed by Anamar AB filed Critical Anamar AB
Publication of CN102573993A publication Critical patent/CN102573993A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2010800325573A 2009-07-31 2010-07-30 治疗炎症的化合物 Pending CN102573993A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0913427.1 2009-07-31
GB0913427A GB0913427D0 (en) 2009-07-31 2009-07-31 Compounds for treatment of imflammation
GBGB1005495.5A GB201005495D0 (en) 2010-03-31 2010-03-31 Compounds for treatment of inflammation
GB1005495.5 2010-03-31
GBGB1010671.4A GB201010671D0 (en) 2010-06-24 2010-06-24 Compounds for treatment of inflammation
GB1010671.4 2010-06-24
PCT/GB2010/001457 WO2011012868A1 (en) 2009-07-31 2010-07-30 Compounds for treatment of inflammation

Publications (1)

Publication Number Publication Date
CN102573993A true CN102573993A (zh) 2012-07-11

Family

ID=42799430

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800325573A Pending CN102573993A (zh) 2009-07-31 2010-07-30 治疗炎症的化合物

Country Status (13)

Country Link
US (1) US20120190751A1 (https=)
EP (1) EP2470270A1 (https=)
JP (1) JP2013500957A (https=)
CN (1) CN102573993A (https=)
AU (1) AU2010277356A1 (https=)
BR (1) BR112012002267A2 (https=)
CA (1) CA2769541A1 (https=)
GB (1) GB2473095A (https=)
IN (1) IN2012DN00928A (https=)
MX (1) MX2012001144A (https=)
NZ (1) NZ598124A (https=)
RU (1) RU2012106467A (https=)
WO (1) WO2011012868A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105561313A (zh) * 2016-01-25 2016-05-11 北京大学 降低5-ht2br含量和抑制其活性的物质在制备治疗和预防动脉粥样硬化产品中的应用
CN107787321A (zh) * 2015-06-22 2018-03-09 安娜玛有限公司 新型5‑ht2拮抗剂

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11208475B1 (en) * 2018-01-30 2021-12-28 Flagship Pioneering Innovations V, Inc. Methods and compositions for treating inflammatory or autoimmune diseases or conditions using serotonin receptor activators
US20210177814A1 (en) * 2018-05-09 2021-06-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of guanabenz or derivates thereof for the treatment of type i ifn-dependent pathologies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011715A2 (en) * 2000-08-07 2002-02-14 Melacure Therapeutics Ab The use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0520032T3 (da) * 1990-03-16 1999-06-14 Beth Israel Hospital Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel
US5696128A (en) * 1994-07-07 1997-12-09 The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College Method of regulating immune function
EP0711553A1 (en) * 1994-08-09 1996-05-15 Mario Cagnoni Use of the Melatonin in the traetment of the articular symptoms of trheumatoid arthritis
WO2001025192A1 (en) * 1999-10-06 2001-04-12 Melacure Therapeutics Ab Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase
US7060711B2 (en) * 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
KR20060088885A (ko) * 2003-09-25 2006-08-07 아카디아 파마슈티칼스 인코포레이티드 뉴로펩티드 ｆｆ 리셉터 2의 작용제를 이용한 신경병증성통증 치료 방법
GB0623381D0 (en) * 2006-11-23 2007-01-03 Acure Pharma Ab Use of a compound as VEGF inhibitor
GB0701170D0 (en) * 2007-01-22 2007-02-28 Imp Innovations Ltd Compositions and uses thereof
GB0715048D0 (en) * 2007-08-02 2007-09-12 Glaxo Group Ltd Novel compounds
EP2411812B1 (en) * 2009-03-24 2013-10-02 AnaMar AB Metabolic profiles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002011715A2 (en) * 2000-08-07 2002-02-14 Melacure Therapeutics Ab The use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATRICK H DESSEIN 等: "Nociceptive and non-nociceptive rheumatological pain: recent developments in the understanding of pathophysiology and management in rheumatioid arthritis and fibromyalgia", 《PAIN REVIEWS》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107787321A (zh) * 2015-06-22 2018-03-09 安娜玛有限公司 新型5‑ht2拮抗剂
CN107787321B (zh) * 2015-06-22 2021-10-01 安娜玛有限公司 新型5-ht2拮抗剂
CN105561313A (zh) * 2016-01-25 2016-05-11 北京大学 降低5-ht2br含量和抑制其活性的物质在制备治疗和预防动脉粥样硬化产品中的应用
CN105561313B (zh) * 2016-01-25 2018-12-25 北京大学 降低5-ht2br含量和抑制其活性的物质在制备治疗和预防动脉粥样硬化产品中的应用

Also Published As

Publication number Publication date
IN2012DN00928A (https=) 2015-04-03
US20120190751A1 (en) 2012-07-26
RU2012106467A (ru) 2013-09-10
JP2013500957A (ja) 2013-01-10
WO2011012868A1 (en) 2011-02-03
GB2473095A (en) 2011-03-02
CA2769541A1 (en) 2011-02-03
BR112012002267A2 (pt) 2016-11-08
MX2012001144A (es) 2012-05-08
EP2470270A1 (en) 2012-07-04
NZ598124A (en) 2014-01-31
GB201012926D0 (en) 2010-09-15
AU2010277356A1 (en) 2012-03-08

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Application publication date: 20120711