CN102573884B - 从蜘蛛毒液中分离的新型肽及其应用 - Google Patents

从蜘蛛毒液中分离的新型肽及其应用 Download PDF

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Publication number
CN102573884B
CN102573884B CN201080041208.8A CN201080041208A CN102573884B CN 102573884 B CN102573884 B CN 102573884B CN 201080041208 A CN201080041208 A CN 201080041208A CN 102573884 B CN102573884 B CN 102573884B
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CN
China
Prior art keywords
peptide
seq
peptides
venom
pain
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Expired - Fee Related
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CN201080041208.8A
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English (en)
Chinese (zh)
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CN102573884A (zh
Inventor
阿隆·梅厄
罗尼特·西姆哈·切尔基
埃拉·科尔贝
耶尔·兰古特
尼西姆·巴扎约
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Alomone Preclinical Ltd
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Alomone Preclinical Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201080041208.8A 2009-09-15 2010-09-13 从蜘蛛毒液中分离的新型肽及其应用 Expired - Fee Related CN102573884B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27233609P 2009-09-15 2009-09-15
US61/272,336 2009-09-15
PCT/IB2010/002275 WO2011033358A2 (en) 2009-09-15 2010-09-13 Novel peptides isolated from spider venom, and uses thereof

Publications (2)

Publication Number Publication Date
CN102573884A CN102573884A (zh) 2012-07-11
CN102573884B true CN102573884B (zh) 2015-01-14

Family

ID=43731158

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080041208.8A Expired - Fee Related CN102573884B (zh) 2009-09-15 2010-09-13 从蜘蛛毒液中分离的新型肽及其应用

Country Status (12)

Country Link
US (1) US8399026B2 (https=)
EP (1) EP2504023B1 (https=)
JP (1) JP5555891B2 (https=)
CN (1) CN102573884B (https=)
AR (1) AR078374A1 (https=)
AU (1) AU2010296994B2 (https=)
BR (1) BR112012005860A2 (https=)
CA (1) CA2774350A1 (https=)
IL (1) IL218382A0 (https=)
MX (1) MX2012003078A (https=)
SG (1) SG179101A1 (https=)
WO (1) WO2011033358A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2830065A1 (en) * 2011-03-16 2012-09-20 Amgen Inc. Potent and selective inhibitors of nav1.3 and nav1.7
NZ621552A (en) * 2011-08-24 2016-12-23 Univ Queensland Pest-controlling agents isolated from spider venom and uses thereof
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US9102751B2 (en) 2012-05-18 2015-08-11 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
EP3973981A1 (en) 2012-05-18 2022-03-30 Janssen Biotech, Inc. Huwentoxin-iv variants and methods of use
JP6086378B2 (ja) * 2012-11-30 2017-03-01 国立大学法人お茶の水女子大学 組み換えヒト膵臓リパーゼの調製方法
US10344060B2 (en) 2013-03-12 2019-07-09 Amgen Inc. Potent and selective inhibitors of Nav1.7
AR096927A1 (es) 2013-03-12 2016-02-10 Amgen Inc INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7
US9624280B2 (en) 2013-10-03 2017-04-18 Janssen Biotech, Inc. Protoxin-II variants and methods of use
GB201410108D0 (en) * 2014-06-06 2014-07-23 Univ Manchester Peptides, and methods and apparatus utilising same
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
JP6985151B2 (ja) 2015-04-02 2021-12-22 ヤンセン バイオテツク，インコーポレーテツド プロトキシン−ｉｉ変異体及びその使用方法
CL2016002890A1 (es) * 2016-11-14 2017-06-30 Univ Antofagasta Peptidos con actividad antimicrobiana
CN107141344A (zh) * 2017-06-01 2017-09-08 长沙沁才生物科技有限公司 一种新型天然活性多肽spkp‑xi
CN107141343A (zh) * 2017-06-01 2017-09-08 长沙沁才生物科技有限公司 一种活性多肽spkp‑xi的制备方法
CN107163124A (zh) * 2017-06-22 2017-09-15 长沙沁才生物科技有限公司 SPNP‑IX在制备Nav1.3通道抑制剂中的应用
CN107496904B (zh) * 2017-09-21 2020-03-17 中南大学 多肽Lycosin-Ⅰ在制备抗炎和抗弓形虫药物中的应用
CN108047323B (zh) * 2017-12-20 2022-04-12 深圳羽众医药科技有限公司 一种固相片段法合成GpTx-1及其类似物和合成方法
WO2022066767A2 (en) * 2020-09-23 2022-03-31 Aldevron, Llc Potent and selective inhibitors of nav1.7

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877026A (en) * 1996-01-03 1999-03-02 Zeneca Limited Analgesic peptides from venom of Grammostola spatulata and use thereof
CN1307900A (zh) * 2000-04-11 2001-08-15 厦门北大之路生物工程有限公司 虎纹捕鸟蜘蛛毒素提取物在制备镇痛药物中的应用

Family Cites Families (5)

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US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
DE3463211D1 (en) 1983-07-01 1987-05-21 Battelle Memorial Institute Biodegradable polypeptide and its use in the sustained release of medicaments
US5417986A (en) 1984-03-16 1995-05-23 The United States Of America As Represented By The Secretary Of The Army Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
WO2002007678A2 (en) * 2000-07-21 2002-01-31 University Of Utah Research Foundation Mu-conopeptides
EP2412719A1 (en) * 2002-12-02 2012-02-01 Xenome Ltd Chi-conotoxin peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877026A (en) * 1996-01-03 1999-03-02 Zeneca Limited Analgesic peptides from venom of Grammostola spatulata and use thereof
CN1307900A (zh) * 2000-04-11 2001-08-15 厦门北大之路生物工程有限公司 虎纹捕鸟蜘蛛毒素提取物在制备镇痛药物中的应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes;Frank Bosmans;《MOLECULAR PHARMACOLOGY》;20061231;第69卷(第2期);图1-2以及第427页讨论 *
Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration;Yucheng Xiao;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20081003;第283卷(第40期);第27311页左栏第2段 *

Also Published As

Publication number Publication date
JP2013504318A (ja) 2013-02-07
EP2504023B1 (en) 2015-07-15
CA2774350A1 (en) 2011-03-24
AU2010296994A1 (en) 2012-04-19
AR078374A1 (es) 2011-11-02
US8399026B2 (en) 2013-03-19
WO2011033358A2 (en) 2011-03-24
EP2504023A4 (en) 2013-04-10
IL218382A0 (en) 2012-04-30
AU2010296994B2 (en) 2013-09-19
EP2504023A2 (en) 2012-10-03
MX2012003078A (es) 2012-08-03
BR112012005860A2 (pt) 2017-01-31
US20110065647A1 (en) 2011-03-17
JP5555891B2 (ja) 2014-07-23
WO2011033358A3 (en) 2011-07-14
SG179101A1 (en) 2012-05-30
CN102573884A (zh) 2012-07-11

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Termination date: 20180913