CN102552796B - 一种治疗慢性胃溃疡的中药组合物 - Google Patents
一种治疗慢性胃溃疡的中药组合物 Download PDFInfo
- Publication number
- CN102552796B CN102552796B CN 201210070397 CN201210070397A CN102552796B CN 102552796 B CN102552796 B CN 102552796B CN 201210070397 CN201210070397 CN 201210070397 CN 201210070397 A CN201210070397 A CN 201210070397A CN 102552796 B CN102552796 B CN 102552796B
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- gastric ulcer
- chinese medicine
- chronic gastric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000007107 Stomach Ulcer Diseases 0.000 title claims abstract description 25
- 201000005917 gastric ulcer Diseases 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 230000001684 chronic effect Effects 0.000 title claims abstract description 20
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 244000307697 Agrimonia eupatoria Species 0.000 claims abstract description 6
- 244000080767 Areca catechu Species 0.000 claims abstract description 6
- 235000016993 Agrimonia Nutrition 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims description 42
- 238000002360 preparation method Methods 0.000 claims description 14
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 6
- 235000005903 Dioscorea Nutrition 0.000 claims description 4
- 235000000504 Dioscorea villosa Nutrition 0.000 claims description 4
- 241001446509 Psoralea Species 0.000 claims description 4
- 241000545442 Radix Species 0.000 claims description 4
- 235000004879 dioscorea Nutrition 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 244000281702 Dioscorea villosa Species 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 208000002193 Pain Diseases 0.000 abstract description 10
- 210000000952 spleen Anatomy 0.000 abstract description 10
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 244000247747 Coptis groenlandica Species 0.000 abstract description 3
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract description 3
- 235000006226 Areca catechu Nutrition 0.000 abstract description 2
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract description 2
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 241000213006 Angelica dahurica Species 0.000 abstract 2
- 241001127714 Amomum Species 0.000 abstract 1
- 241001313855 Bletilla Species 0.000 abstract 1
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 244000241463 Cullen corylifolium Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 208000025865 Ulcer Diseases 0.000 description 18
- 231100000397 ulcer Toxicity 0.000 description 18
- 239000000843 powder Substances 0.000 description 14
- 210000002784 stomach Anatomy 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 229940079593 drug Drugs 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 230000007812 deficiency Effects 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 239000013641 positive control Substances 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000004375 Dextrin Substances 0.000 description 6
- 229920001353 Dextrin Polymers 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 235000019425 dextrin Nutrition 0.000 description 6
- 210000003734 kidney Anatomy 0.000 description 6
- 210000004877 mucosa Anatomy 0.000 description 6
- 230000001737 promoting effect Effects 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 206010047700 Vomiting Diseases 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 238000005469 granulation Methods 0.000 description 4
- 230000003179 granulation Effects 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 241000234273 Dioscorea Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 206010067171 Regurgitation Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 210000004907 gland Anatomy 0.000 description 3
- 230000000762 glandular Effects 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 208000004371 toothache Diseases 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000037803 Coptis deltoidea Species 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 241000218180 Papaveraceae Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000001087 myotubule Anatomy 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000007779 soft material Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241001105170 Angelica anomala Species 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 241001313857 Bletilla striata Species 0.000 description 1
- 241000459479 Capsula Species 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 241000037740 Coptis chinensis Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 241000587240 Cynanchum Species 0.000 description 1
- 241000234272 Dioscoreaceae Species 0.000 description 1
- 206010013183 Dislocation of vertebra Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017815 Gastric perforation Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 241000790228 Nardostachys jatamansi Species 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 201000000660 Pyloric Stenosis Diseases 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010040849 Skin fissures Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000053227 Themus Species 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 206010061577 Ulcer haemorrhage Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 241000331449 Vincetoxicum pycnostelma Species 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 235000000125 common agrimony Nutrition 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940059082 douche Drugs 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 235000021271 drinking Nutrition 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 210000000569 greater omentum Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
- 229960000620 ranitidine Drugs 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 210000002417 xiphoid bone Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗慢性胃溃疡的中药组合物，涉及中医药技术领域。其由如下重量份的中药材制备而成：白及8-12份、白芷15-20份、甘松3-6份、仙鹤草10-15份、槟榔8-12份、当归8-12份、元胡8-12份、徐长卿8-12份、砂仁4-8份、山药20-30份、黄连4-8份、补骨脂8-12份。本发明涉及的中药组合物对慢性胃溃疡具有显著疗效，并可用于健脾理气和消胀止痛、安全性高。
Description
技术领域
本发明涉及中医药技术领域，特别是涉及一种治疗慢性胃溃疡的中药组合物。
背景技术
胃溃疡是消化系统常见病，多发病。比较明显的病因为幽门螺杆菌感染、服用非甾体消炎药(NSATD)以及胃酸分泌过多；另外还可以由遗传因素和情绪波动、过度劳累、饮食失调、吸烟、酗酒等因素引起。胃溃疡由于病情延绵，病情复杂，又与精神情绪有关，病情加重或治疗不及时，还会导致胃出血、胃穿孔、幽门梗阻和癌变等恶劣后果，严重危害人民健康，所以应予以高度的重视。胃溃疡在中医属于“脾虚”、“胃虚”、“脾胃虚寒”、“胃肮痛”、“吐酸”、“呕吐”、“反胃”等范畴。中药以其毒副作用小，安全有效而备受关注。
目前市场上治疗胃溃疡的西药种类很多，如西咪替丁、雷尼替丁、法莫替丁等，这些药品治疗胃溃疡效果显著，但毒副作用太大，对肝肾有损伤，H2受体阻滞剂有不同程度的头昏、嗜睡、腹痛、恶心等不良反应。中成药虽然也有很多，但大多数缓解疼痛的起效时间过长，效果不明显。
发明内容
本发明根据传统中医理论，经过对药物组分的大量筛选、重组、尝试、又通过大量动物实验研究作出的。因此，本发明的目的在于提供了一种更加安全可靠的治疗慢性胃溃疡的中药组合物。
本发明的目的是这样实现的：
一种治疗慢性胃溃疡的中药组合物，由如下重量份的活性成分制备而成：白及8-12份、白芷15-20份、甘松 3-6份、仙鹤草10-15份、槟榔 8-12份、当归8-12份、元胡8-12份、徐长卿8-12份、砂仁4-8份、山药20-30份、黄连4-8份、补骨脂 8-12份。
在一个最优选的实施例中，所述的治疗慢性胃溃疡的中药组合物，由如下重量份的活性成分制备而成：白及10份、白芷18份、甘松 5份、仙鹤草12份、槟榔10份、当归10份、元胡10份、徐长卿10份、砂仁6份、山药25份、黄连6份、补骨脂 10份。
进一步优选地，所述的治疗慢性胃溃疡的中药组合物是口服制剂。
再进一步优选地，所述的治疗慢性胃溃疡的中药组合物是口服液、颗粒剂、片剂和胶囊剂。
通过动物试验研究发现，由上述活性成分组成的药物组合物在治疗慢性胃溃疡模型大鼠方面具有显著的疗效。因此，本发明的第二个目的在于提供一种医药新用途，即上述的中药组合物在制备治疗慢性胃溃疡的中药中的应用。
根据中医药史料记载，上述中药材具有如下药理活性和功能主治：
白及：收敛止血，消肿生肌。用于咳血吐血，外伤出血，疮疡肿毒，皮肤皲裂；肺结核咳血，溃疡病出血。选用兰科植物白及Bletilla striata（Thunb.）Reichb. f.的干燥块茎。仙鹤草又名西洋龙芽草，选用干燥全草。
白芷：祛风湿，活血排脓，生肌止痛。用于头痛、牙痛、鼻渊、肠风痔漏、赤白带下、痈疽疮疡、皮肤瘙痒。选用伞形科植物川白芷的根。
甘松：行气止痛，开郁醒脾。外用祛湿消肿。用于中焦寒凝气滞，脾胃不和，食欲不振，呕吐；外用治牙痛。选用败酱多年生草本甘松Nardostachys jatamansi DC.的干燥根茎及根。
仙鹤草：收敛止血，止痢，杀虫。广泛用于各种出血之证，例如：吐血、尿血、便血、崩漏、咯血、衄血，赤白痢疾，劳伤脱力，痈肿，跌打，创伤出血等证。
槟榔：驱虫；消积；下气；行水；截疟。虫积；食滞；脘腹胀痛；泻痢后重；脚气；水肿；疟疾。选用棕榈科植物槟榔Areca catechu Linn.的种子。
当归：补血活血，调经止痛，润肠通便。用于血虚萎黄、眩晕心悸、月经不调、经闭痛经、虚寒腹痛、肠燥便秘、风湿痹痛、跌扑损伤、痈疽疮疡。选用伞形科植物当归Angelica sinensis (Oliv.) Diels 的干燥根。
元胡：活血化瘀、行气止痛，用于全身各部气滞血瘀之痛，痛经，经闭，症瘕，产后瘀阻，跌扑损伤，疝气作痛。选用罂粟科(Papaveraceae)植物延胡索或齿瓣延胡索的块茎。
徐长卿：疏风解热，行气活血。治一切痧症和肚痛， 胃气痛，食积，霍乱。选用萝藦科牛皮消属植物徐长卿Cynanchum paniculatum （Bge.）Kitag. 的干燥根及根茎。
砂仁：用于湿浊中阻，脘痞不饥，脾胃虚寒，呕吐泄泻，妊娠恶阻，胎动不安。选用姜科植物阳春砂、绿壳砂或海南砂的干燥成熟果实。
山药：补脾养胃，生津益肺，补肾涩精。 用于脾虚食少，久泻不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。选用薯蓣科植物薯蓣Dioscorea opposita Thunb. 的干燥根茎。
黄连：清热燥湿，泻火解毒。用于湿热痞满，呕吐吞酸，泻痢，黄疸，高热神昏，心火亢盛，心烦不寐，血热吐衄，目赤，牙痛，消渴，痈肿疔疮；外治湿疹，湿疮，耳道流脓。酒黄连善清上焦火热。选用毛茛科植物黄连Coptis chinensis Franch.三角叶黄连Coptis deltoidea C.Y.Chenget Hsiao或云连Coptis teeta Wall.的干燥根茎。
补骨脂：补肾助阳；纳气平喘；温脾止泻。主肾阳不足；下元虚冷；腰膝冷痛；阳痿遗精；尿频；遗尿；肾不纳气；虚喘不止；脾肾两虚；大便久泻；白癜风；斑秃；银屑病。选用豆科植物补骨脂的果实。
将上述各中药材制备成本发明的复方口服液的制备方法，包括如下步骤：称取清洗干净且干燥的药材合并，加水煎煮两次，合并煎液，减压浓缩至65℃时相对密度为1.15-1.20，加乙醇使含醇量的体积百分比达75-85%，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.25-1.30并回收乙醇得浓缩液，将浓缩液加水及辅料配制成口服液。
将上述各中药材制备成本发明的复方颗粒剂的制备方法，包括如下步骤：
第一步，制备清膏粉：
1）备料：按处方量称取清洗干净的上述中药材，备用；
2）煎煮：加水煎煮，第一煎每罐加水为药材总量的6-10倍，加热沸腾后保持2-4小时，提取液经过200目过滤器过滤进入沉淀罐；第二煎加入药材量3-5倍的水加热提取，保沸2-4小时，提取液经过200目过滤器过滤进入沉淀罐；
3）沉淀：沉淀罐中提取液沉淀24～36小时，抽取上清液经过200目过滤器过滤至三效蒸发器中，沉淀物按废弃物处理；
4）浓缩：当上清液在三效蒸发器中浓缩至相对密度为1.00～1.10（40℃测定）时，将稀清膏经200目过滤器过滤抽入真空减压浓缩罐中，浓缩并混合至相对密度为1.30～1.32（90℃测定）时出膏，至贮膏桶内，备用；
5）干燥：其中真空度：-0.1MPa，温度：78～82℃，干燥时间20～24小时；
6）打粉：粉碎细度80目筛，得到清膏粉；
第二步，按照清膏粉：糊精： 55%乙醇为1：1～3：0.1～0.3的重量比称取清膏粉、糊精与55%乙醇，其中55%乙醇是指体积浓度为55%的乙醇水溶液；
第三步，将清膏粉与糊精投入槽型混合机中，搅拌20分钟，边搅拌边缓缓加入55%乙醇，至制成软材，用12目不锈钢筛制粒，65～75℃干燥2小时，取出，放凉即得所述的颗粒剂。
与现有技术相比，本发明具有如下优点和显著地进步：（1）疗效好。本发明的中药组合物能显著减小慢性胃溃疡模型大鼠的溃疡体积和溃疡面积，可促进溃疡愈合，对慢性胃溃疡大鼠有良好的治疗作用。（2）安全性高。由于本发明的药物由采用传统中药材制备而成，毒性低，患者用药更安全。
具体实施方式
下面通过实施例进一步说明本发明。本发明的实施例仅仅是用于说明本发明，而不是对本发明的限制，在本发明的构思前提下对本发明制备方法的简单改进都属于本发明要求保护的范围。
实施例1
生药处方：白及8份、白芷15份、甘松 5份、仙鹤草15份、槟榔12份、当归8份、元胡8份、徐长卿12份、砂仁8份、山药20份、黄连6份、补骨脂 8份。
制备方法：称取上述处方量的药材合并，加水煎煮两次，第一次加水为药材重量的10倍量，煎煮2h，第二次加水为药材重量的8倍量，煎煮1.5h，合并煎液，0.08MPa、65℃下减压浓缩至65℃时相对密度为1.15，加95%(v/v)乙醇使含醇量达85%(v/v)， 搅拌， 静置过夜，过滤，滤液在0.08MPa、65℃条件下减压浓缩成至65℃时相对密度为1.30，加水及蔗糖配制成口服液。
实施例2
生药处方：白及10份、白芷18份、甘松 5份、仙鹤草12份、槟榔10份、当归10份、元胡10份、徐长卿10份、砂仁6份、山药25份、黄连6份、补骨脂 10份。
制备方法：
第一步，制备清膏粉：
1）备料：按处方量称取清洗干净的上述中药材，备用；
2）煎煮：加水煎煮，第一煎每罐加水为药材总量的6倍，加热沸腾后保持4小时，提取液经过200目过滤器过滤进入沉淀罐；第二煎加入药材量6倍的水加热提取，保沸4小时，提取液经过200目过滤器过滤进入沉淀罐；
3）沉淀：沉淀罐中提取液沉淀30小时，抽取上清液经过200目过滤器过滤至三效蒸发器中，沉淀物按废弃物处理；
4）浓缩：当上清液在三效蒸发器中浓缩至相对密度为1.05（40℃测定）时，将稀清膏经200目过滤器过滤抽入真空减压浓缩罐中，浓缩并混合至相对密度为1.30～1.32（90℃测定）时出膏，至贮膏桶内，备用；
5）干燥：其中真空度：-0.1MPa，温度：78～82℃，干燥时间24小时；
6）打粉：粉碎细度80目筛，得到清膏粉；
第二步，按照清膏粉：糊精： 55%乙醇为1：2：0.2的重量比称取清膏粉、糊精与55%乙醇，其中55%乙醇是指体积浓度为55%的乙醇水溶液；
第三步，将清膏粉与糊精投入槽型混合机中，搅拌20分钟，边搅拌边缓缓加入55%乙醇，至制成软材，用12目不锈钢筛制粒， 75℃干燥2小时，取出，放凉即得所述的颗粒剂。
实施例3 本发明中药组合物对慢性胃溃疡大鼠的影响
SD大鼠随机取10只作空白组，乙醚麻醉后于剑突下经腹壁正中线做1. 5cm的切口，暴露胃后即缝合行假手术处理；其余大鼠暴露胃后用内径7mm 的玻璃圆筒按在胃小弯角切迹下方约5mm的胃前壁浆膜面上，将99. 9%的乙酸0.25m1注入圆筒内，l min后滤纸吸净乙酸，移开圆筒，生理盐水局部冲洗，大网膜包裹受侵蚀胃壁，还纳胃体逐层缝合。术后常规抗感染3天，5天后选取存活造模大鼠48只，随机分为模型对照组、中药低、高剂量组、阳性对照组。术后第5天开始，给药组和阳性对照组分别按表1中的剂量灌胃给药，每日2次，共3周；空白和模型组灌胃给予等量生理盐水，每日2次，共3周。
表1. 实验动物分组及给药
| 分组 | 样本量（只） | 剂量 |
| 空白对照组 | 10 | 同体积的生理盐水 |
| 模型对照组 | 12 | 同体积的生理盐水 |
| 阳性对照组 | 12 | 0.1g·kg-1·d-1盐酸雷尼替丁 |
| 中药低剂量组 | 12 | 1.5g·kg-1·d-1清膏粉（实施例2制备） |
| 中药高剂量组 | 12 | 3.0g·kg-1·d-1清膏粉（实施例2制备） |
标本收集及指标检测方法：颈椎脱臼法处死大鼠，打开腹腔，分离鼠胃，沿胃大弯
剪开，生理盐水洗净后置平皿中，用微量进样器向溃疡凹内注生理盐水，以所能容纳的液体量，作为溃疡体积；用游标卡尺测溃疡最大直径((D)与宽度(d)，用公式s = (Dｘd) ｘ兀/4求出溃疡面积。然后，沿溃疡周围切下约1cmｘ1cm的胃壁，4%甲醛固定5h，脱水，石蜡包埋切片，苏木精-伊红染色，光镜下观察再生黏膜组织，评价溃疡愈合质量。
实验结果：模型组出现显著的溃疡，说明造模成功。中药组及阳性对照组的溃疡体积和溃疡面积显著小于模型组（P＜0.05或P＜0.01)，详细结果见表2。
溃疡愈合质量：（1）模型组：再生黏膜明显较正常变薄，腺体数量少，大小不等，明显扭曲及囊状扩张，排列不规则，腺细胞形态不规则，黏膜下水肿，大量炎症细胞浸润，成纤维细胞、新生血管少，再生胶原纤维少且排列无规则。（2）阳性对照组：再生黏膜薄，腺体数量少，大小相似，囊状扩张明显，排列尚整齐，腺细胞较大，黏膜下大量炎症细胞浸润，成纤维细胞、新生血管较少，再生胶原纤维及少量再生肌纤维排列紊乱。（3）中药高剂量组：再生黏膜轻度变薄，腺体数量较多，大小相似，轻度囊状扩张，排列较整齐，腺细胞形态近似正常；黏膜下炎症细胞浸润相对轻，成纤维细胞、新生血管较多，再生胶原纤维及少量再生肌纤维排列较整齐；溃疡愈合质量优于阳性对照组。
表2 本发明药物对慢性胃溃疡大鼠的影响(x±sd)
| 组别 | 溃疡体积（μl） | 溃疡面积(mm2) |
| 空白对照组 | 0 | 0 |
| 模型对照组 | 21.03±3.15 | 23.16±6.92 |
| 阳性对照组 | 17.27±3.96￥ | 16.82±4.15￥￥ |
| 中药低剂量组 | 16.15±2.42￥￥ | 16.16±5.61￥￥ |
| 中药高剂量组 | 14.31±2.83￥￥* | 15.60±3.82￥￥ |
与模型对照组比较，￥ P＜0.05，￥￥ P＜0.01；
与阳性药组比较，*P＜0.05，**P＜0.01。
Claims (4)
1.一种治疗慢性胃溃疡的中药组合物，其特征在于：由如下重量份的活性成分制备而成：白及8-12份、白芷15-20份、甘松 3-6份、仙鹤草10-15份、槟榔 8-12份、当归8-12份、元胡8-12份、徐长卿8-12份、砂仁4-8份、山药20-30份、黄连4-8份、补骨脂 8-12份。
2.根据权利要求1所述的治疗慢性胃溃疡的中药组合物，其特征在于：由如下重量份的活性成分制备而成：白及10份、白芷18份、甘松 5份、仙鹤草12份、槟榔10份、当归10份、元胡10份、徐长卿10份、砂仁6份、山药25份、黄连6份、补骨脂 10份。
3.根据权利要求1或2所述的治疗慢性胃溃疡的中药组合物，其特征在于：所述中药组合物是口服制剂。
4.根据权利要求3所述的治疗慢性胃溃疡的中药组合物，其特征在于：所述中药组合物是口服液、颗粒剂、片剂或胶囊剂中的任一种。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210070397 CN102552796B (zh) | 2012-03-17 | 2012-03-17 | 一种治疗慢性胃溃疡的中药组合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210070397 CN102552796B (zh) | 2012-03-17 | 2012-03-17 | 一种治疗慢性胃溃疡的中药组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102552796A CN102552796A (zh) | 2012-07-11 |
| CN102552796B true CN102552796B (zh) | 2013-04-10 |
Family
ID=46400250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210070397 Active CN102552796B (zh) | 2012-03-17 | 2012-03-17 | 一种治疗慢性胃溃疡的中药组合物 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102552796B (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456595A (zh) * | 2016-01-05 | 2016-04-06 | 丁勇剑 | 一种治疗胃溃疡的中药制剂及其制备方法和用途 |
| CN106110210A (zh) * | 2016-08-09 | 2016-11-16 | 李双双 | 一种治疗胃溃疡的中药及其制备方法 |
| CN106421186A (zh) * | 2016-10-26 | 2017-02-22 | 李淑梅 | 一种治疗慢性胃溃疡的中药组合物及制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095952A (zh) * | 1993-06-04 | 1994-12-07 | 陈顺志 | 一种新型药茶的生产方法 |
-
2012
- 2012-03-17 CN CN 201210070397 patent/CN102552796B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095952A (zh) * | 1993-06-04 | 1994-12-07 | 陈顺志 | 一种新型药茶的生产方法 |
Non-Patent Citations (2)
| Title |
|---|
| 于晓.《胃脘痛病证的古今文献研究与学术源流探讨》.2008, * |
| 张兆辉.《由消化性溃疡相关文献探讨中医治疗与处方用药规律》.2006, * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102552796A (zh) | 2012-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103285310B (zh) | 一种红景天复方组合物在制备治疗胃溃疡的药物中的用途 | |
| CN105749179A (zh) | 治疗代谢综合征的中药组合物 | |
| CN102552796B (zh) | 一种治疗慢性胃溃疡的中药组合物 | |
| CN104857366A (zh) | 一种神经外科术前干预药物组合物及其应用 | |
| CN103933405A (zh) | 用于治疗气血两虚型烧伤的药物组合物及其制备方法 | |
| KR101600751B1 (ko) | 녹용을 함유하는 여성 불임증 치료용 한약 조성물 제조 방법 | |
| CN105214032A (zh) | 治疗消化性溃疡的固体分散片剂 | |
| CN105214037A (zh) | 治疗消化性溃疡的固体分散胶囊剂 | |
| CN105250946A (zh) | 治疗消化性溃疡的固体分散体 | |
| CN105214035A (zh) | 一种治疗消化性溃疡片剂及其制备方法 | |
| CN105233201A (zh) | 治疗消化性溃疡的固体分散颗粒剂 | |
| CN105214031A (zh) | 一种治疗消化性溃疡的水提物颗粒剂 | |
| CN1250249C (zh) | 一种治疗妇科炎症的中药外用洗剂 | |
| CN104257871B (zh) | 用于治疗湿热毒蕴型急性网状淋巴管炎的药物组合物及其制备方法 | |
| CN105194608A (zh) | 治疗消化性溃疡的微粉胶囊剂 | |
| CN105214030A (zh) | 一种药物组合物在制备治疗胃溃疡的药物中的用途 | |
| CN105878716A (zh) | 一种防治鸡心包积水综合征的中草药复方制剂 | |
| CN105250951A (zh) | 一种治疗消化性溃疡药物的制备方法 | |
| CN104815131A (zh) | 一种用于治疗鸡痛风的药物组合物及其制备方法 | |
| CN105456933A (zh) | 一种活血化瘀、通经活络的中药及其制备方法 | |
| CN104622983A (zh) | 治疗直肠炎的中药组合物及其制备方法 | |
| CN102526595B (zh) | 一种用于治疗胃脘痛的中药组合物及制备方法和应用 | |
| CN105169277A (zh) | 一种保肝利胆的栀子口服液及其制备方法 | |
| CN104435950A (zh) | 一种治疗上消化道出血症的中药止血散及其制备方法 | |
| CN113797307A (zh) | 一种慢性肠胃炎用中药制剂、制备方法及其服用方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NANTONG HIGH-TECH ZONE TECHNOLOGY CITY INVESTMENT Free format text: FORMER OWNER: XU CONGYU Effective date: 20130924 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276017 LINYI, SHANDONG PROVINCE TO: 226000 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130924 Address after: 226000 West Road, high tech Industrial Development Zone, Jiangsu, Nantong Patentee after: Nantong hi tech Zone Science and Technology City Investment Development Co.,Ltd. Address before: 276017 A302 building, Linyi hi tech Industrial Development Zone, Shandong, China Patentee before: Xu Congyu |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170413 Address after: 226300 Nantong high tech Zone, Jiangsu province Jinqiao West Road, No. 8, No. Patentee after: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Address before: 226000 West Road, high tech Industrial Development Zone, Jiangsu, Nantong Patentee before: Nantong hi tech Zone Science and Technology City Investment Development Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A traditional Chinese medicine composition for treating chronic gastric ulcer Effective date of registration: 20201216 Granted publication date: 20130410 Pledgee: Nantong Jiangsu rural commercial bank Limited by Share Ltd. Pledgor: JIANGSU ZODIAC PHARMACEUTICAL Co.,Ltd. Registration number: Y2020980009463 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20211118 Granted publication date: 20130410 Pledgee: Nantong Jiangsu rural commercial bank Limited by Share Ltd. Pledgor: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Registration number: Y2020980009463 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Traditional Chinese medicine composition for treating chronic gastric ulcer Effective date of registration: 20211119 Granted publication date: 20130410 Pledgee: Nantong Jiangsu rural commercial bank Limited by Share Ltd. Pledgor: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Registration number: Y2021980012846 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20221114 Granted publication date: 20130410 Pledgee: Nantong Jiangsu rural commercial bank Limited by Share Ltd. Pledgor: JIANGSU ZODIAC PHARMACEUTICAL CO.,LTD. Registration number: Y2021980012846 |