CN102552423A - Medicinal composition for treating migraine - Google Patents
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Abstract
The invention discloses a medicinal composition for treating migraine and relates to the technical field of Chinese medicines. The medicinal composition is prepared from the following raw materials in part by weight: 30 to 60 parts of ligusticum chuanxiong, 10 to 25 parts of long pepper, 20 to 50 parts of Chinese angelica, 20 to 50 parts of Manchurian wild ginger, 18 to 40 parts of angelica dahurica, 15 to 30 parts of divaricate saposhnikovia root, 1 to 5 parts of camphor and 10 to 20 parts of chrysanthemum. The medicinal composition is prepared from a few raw materials and quick in response, has obvious effects, does not have toxic or side effects and fully achieves the effects of addressing both the symptoms and root causes and radically curing the migraine. A preparation of the medicinal composition is simple in technologies and is suitable for industrial production.
Description
Technical field
The present invention relates to the Chinese medicine technical field, particularly relate to a kind of migrainous pharmaceutical composition that is used to treat.
Background technology
Migraine is a kind of chronic neurological property disease relevant with the cerebral neurovascular functional disorder, good sending out in the young and the middle aged, with in the outbreak repeatedly, the severe headache is characteristics.Show as violent pulsatile headache, with nausea and vomiting more.
If the untimely treatment of migraineur; Tend to bring psychology and physiological harm to the patient, even influence patient's working and learning, be embodied in: it is healthy 1) to influence the human psychological: this is disease because the people suffers from headaches for a long time; Personality changes, and often disposition becomes irascible.Because of obstinate, life receives significant impact, and is weak in mind, loses confidence again; 2) influence people's life and work: the most directly be exactly the influence sleep, it is good not having several headache patients sleeps, the lighter's difficulty falling asleep, the dormancy of weight person's the entire night difficulty.Because do not have enough sleep, daytime, work also was greatly affected just out of spirits.And the part patient is arranged wilfully is just outbreak of work, very delays thing; 3) influence health: the people has a headache gratuitous can the appearance, and the normal person is in fatigue, and anxiety also can be had a headache during flu, but just for the moment, should recover normal very soon.If not only do not recover, go back frequent, pain is exactly a kind of disease unbearably.Time has been grown and must people's cardiovascular and cerebrovascular vessel have been had a negative impact, because the cerebral thrombosis of headache back outbreak, hypertension, cerebral hemorrhage, clinical very common.
In recent years, in, pathogenetic research all has remarkable progress to doctor trained in Western medicine to migraine.Doctor trained in Western medicine thinks that migrainous treatment comprises stage of attack treatment and two aspects of intermission treatment.In case the outbreak performance appears, even tendency, just should in time take analgesic drug product, like somedon, bufferin or paracetamol etc.These medicines are applicable to gently, the moderate migraine.Bad or headache can be selected Qu Putan class medicine for use when heavier like above-mentioned effect of drugs.Domestic present use sumatriptan and Zomitriptan arranged, this is the specific medicament of treatment migraine.But often the side effect of Western medicine is big and be prone to drug dependence, brings great inconvenience to the patient.
Migraine thinks that on theory of Chinese medical science it belongs to categories such as " headache ", " wind syndrome of head ", " headache due to upward adverse flow of channel-QI ".Li Dongyuan " wound is distinguished in eastern wall ten books " is divided into headache due to invasion of exogenous pathogens and headache due to internal injury to headache, and points out migrainous name of disease clearly: " like the half of pain person of head ... this migraine also." from ancient times to the present, each doctor family is all thought mainly at being invaded by exogenous pathogen to migrainous pathogenic factor, feelings will internal injury, eating and drinking without temperance, prolonged illness causes visceral dysfunctions such as causing liver,spleen,kidney on the basis of the stasis of blood, and wind is attacked the brain network, the turbid retardance of expectorant, obstruction of collaterals by blood stasis causes.On differentiation of syndromes of meridian, mainly be that the heresy of six climate exopathogens injures three YANG meridians, and wherein with shaoyang channel, Taiyang channel for seeing more; Internal injury is because stagnation of liver-QI liver-fire injures yin collaterals, and it is foster that the kidney yin deficiency of kidney-essence causes brain to be lost, and dysfunction of the spleen in transportation causes deficiency of qi and blood or turbid interior living the resistance in meridians of expectorant caused a disease.
Since hundreds of years, the Chinese medicine migraine has accumulated rich experience, obtains good and clinical curative effect, and has special advantages.The migrainous Chinese medicine composition of treatment is existing a variety of at present, but has his own strong points, and shortening is also respectively arranged.
Summary of the invention
The objective of the invention is to develop the migrainous pharmaceutical composition of a kind of treatment, can fundamentally treat patient's disease such as migraine, angioneurotic headache, trigeminal neuralgia, eye socket pain.According to motherland's medical science invasion by pathogenic cold then using warming therapy, Yu Ze dredge principle, the present invention's dispelling cold by warming the meridian of writing out a prescription, depressed liver-energy dispersing and QI regulating obviously improves migraineur's subjective symptoms.
The present invention is a kind of to be treated migrainous pharmaceutical composition and is processed by the raw material of following weight portion: Rhizoma Chuanxiong 30-60 part, Fructus Piperis Longi 10-25 part, Radix Angelicae Sinensis 20-50 part, Herba Asari 20-50 part, Radix Angelicae Dahuricae 18-40 part, windproof 15-30 part, Camphora 1-5 part, Flos Chrysanthemi 10-20 part.
Further preferred, the present invention is a kind of to be treated migrainous pharmaceutical composition and is processed by the raw material of following weight portion: 40 parts of Rhizoma Chuanxiongs, 18 parts of Fructus Piperis Longi, 20 parts of Radix Angelicae Sinensis, 30 parts of Herba Asaris, 22 parts of the Radixs Angelicae Dahuricae, windproof 18 parts, 1 part of Camphora, 14 parts of Flos Chrysanthemis.
Rhizoma Chuanxiong in the prescription of the present invention: another name Rhizoma Chuanxiong (" book on Chinese herbal medicine "), blood-activating and qi-promoting, wind-expelling pain-stopping; Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia; For medicine first choice of the treatment headache, be the monarch drug among the we.Modern medicine and pharmacology discovers that Rhizoma Chuanxiong has tangible sedation.Movable inhibited to animal brain when Rhizoma Chuanxiong volatile oil is a small amount of, and medulla oblongata respiratory center, vasomotor center and spinal reflex maincenter are had excitation.In vitro testses such as antibacterial action show that Rhizoma Chuanxiong has inhibitory action to large intestine, dysentery (Song Nei Shi), distortion, green pus, typhoid fever, Salmonella paratyphi and vibrio cholera etc.Rhizoma Chuanxiong water logging agent (1:3) also has inhibitory action to some pathogenic dermatophytes in vitro.
Fructus Piperis Longi: have another name called Fructus Piperis Longi, be ministerial drug of the present invention.The BIBO warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving has tangible sedation, is used for coldness and pain in the epigastrium, vomits, has loose bowels, migraine, nasal sinusitis, external treatment toothache, coronary heart disease, angina pectoris." detailed outline ": Fructus Piperis Longi, be headache, nasal sinusitis, toothache key medicine, get it and hotly can go into Yangming Channel and loose superficial heat also., " book on Chinese herbal medicine justice ": Fructus Piperis Longi, the principal agent of spleen-kidney vacuity cold.Only being on the point of the lake meaning is headache, nasal sinusitis key medicine, gets it and hotly can go into Yang Ming and loose superficial heat.By the intrinsic very cold disease of headache should be with the big temperature person of Da Xin, but nasal sinusitis, toothache, this all fiery disease, ancients' idol is covered the justice of also using corrigent with the hot medicine that looses, and as guide, is on the point of the lake and thinks diffusing superficial heat unexpectedly, probably is to misunderstand, stone stupid and it, also non-.
Radix Angelicae Sinensis: formal name used at school Angelica sinensis, herbaceos perennial is enriched blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Have anti-hypoxia, anticancer, improve looks, enrich blood invigorate blood circulation, effect such as antibacterial, arteriosclerosis.The Japan scholar reports that Japanese Taihe county Radix Angelicae Sinensis (An-gelicaacutilobaKitagalia) volatile oil has effects such as calmness, hypnosis, analgesia, anesthesia.
Herba Asari: Herba Asari has another name called thin ginseng, bowl of a pipe flower.Cold expelling induces sweat; Wind-expelling pain-stopping; Warming the lung to resolve fluid-retention; Sensible.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; The phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.Use normal and Rhizoma Chuanxiong Herba Ephedrae, Radix Aconiti Lateralis Preparata, Rhizoma Et Radix Notopterygii, the Radix Angelicae Dahuricae are equal to usefulness as analgesic.
The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.With controlling anemofrigid cold, fever with aversion to cold, neck are had a pain, nasal obstruction person, and normal and Folium Perillae, Herba Asari, Herba Schizonepetae are equal to usefulness.If control anemopyretic cold, neck is had a pain, and many and Flos Lonicerae, Fructus Forsythiae, Radix Puerariae are equal to usefulness.If it is wet to control the anemofrigid cold folder, fever with aversion to cold, neck are had a pain, the vague aching of limbs person, often use with compatibilities such as windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentiss again.As control exterior syndrome and stop, to do during headache, medicines such as Rhizoma Chuanxiong, Herba Schizonepetae, Herba Asari, Fructus Viticis are often joined in touching wind syndrome of head headache with the passing of time.Control toothache, belong to air-cooled person, use together with Herba Asari, Fructus Viticis, Nidus Vespae.Modern study shows that the Radix Angelicae Dahuricae contains Radix Angelicae Dahuricae element, Radix Angelicae Dahuricae ether, angelicotoxin etc., has infection, analgesia, spasmolytic, antitumaous effect.
Windproof: acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion is jerked surely; Cure mainly the diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.
Camphora: hot, heat, poisonous.GUIXIN, spleen channel.Effect dehumidifying parasite killing, warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Cure mainly scabies pruritus, traumatic pain, toothache.The general action of Camphora mainly is the stimulating central nervous system system, and taking orally needs strict control dosage, takes generally to be higher than 0.5g at every turn.
Flos Chrysanthemi: for the dry capitulum of feverfew Flos Chrysanthemi Chrysanthemum morifolium Ramat, be Chinese conventional Chinese medicine, have dispelling wind, heat clearing away, make eye bright
,The effect of detoxifcation.Diseases such as main treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Modern pharmacological research shows, Flos Chrysanthemi has treatment coronary heart disease, brings high blood pressure down, prevents hyperlipidemia, antibiotic, antiviral, antiinflammatory, the anti-ageing multiple pharmacologically active of waiting for a long time.Diffusing wind heat clearing away, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.
Rhizoma Chuanxiong is a monarch drug in the present invention prescription, Fructus Piperis Longi, when being classified as ministerial drug, the effect of playing monarch together altogether in Herba Asari, the Radix Angelicae Dahuricae, windproof, Camphora, all medicines of Flos Chrysanthemi.Can fundamentally treat patient's disease such as migraine, angioneurotic headache, trigeminal neuralgia, eye socket pain.
Pharmaceutical composition of the present invention can give the consumption of each 2-3g respectively according to the difference of patient age, every day 2 times, sooner or later respectively once.General patient takes in this medicine 10-30 minute pain symptom will be alleviated, and 7 days one courses of treatment of pharmaceutical composition of the present invention, serve on the 1-2 course of treatment.
Preparation process of the present invention is simple, directly pulverizes mix homogeneously and gets final product by the conventional formulation prepared.Preferably, can process clinical acceptable peroral dosage form by conventional formulation technology.
Described peroral dosage form is liquid oral dosage form or oral dosage form, is preferably oral dosage form, and described oral dosage form is tablet, granule, capsule, soft capsule, pill.
Aforementioned dosage form most preferably is capsule.
The method for preparing of capsule of the present invention is following:
A, according to the present invention prescription, take by weighing the raw medicinal material Rhizoma Chuanxiong, Fructus Piperis Longi, Radix Angelicae Sinensis, Herba Asari, the Radix Angelicae Dahuricae of recipe quantity, windproof, Camphora, Flos Chrysanthemi; Clean, dry;
B, with above-mentioned pulverizing medicinal materials, cross 80 mesh sieves, behind ultraviolet-sterilization, insert capsule No. 0, promptly get.
The present invention also can water is fried takes in addition.
The present invention compared with prior art has following advantage:
1) pharmaceutical composition of the present invention is through the clinical patients verification experimental verification; At aspects such as treatment migraine, angioneurotic headache, trigeminal neuralgia, supraorbital bone pain, eye socket pains better curative effect is arranged; Especially very obvious to migraineur's effect; It is rapid to have onset, alleviates characteristics such as headache rapidly.
2) the present invention's medication of writing out a prescription is simplified, and adopts natural Chinese medicinal herb after compatibility processing, to process, patient's back instant effect of taking medicine, and short treating period, evident in efficacy, given full play to its treating both the principal and secondary aspects of a disease of the traditional Chinese medical science, the characteristics of curing the disease and digging up the roots.
3) pharmaceutical composition consumption of the present invention is few, cheap, and usage is simple.
Model case of the present invention:
Lou so-and-so, the man, 50 years old, had a headache 8 years, often outbreak, do too much inspection in many hospitals January for several times when frequent, and no abnormal, took multiple Western medicine, outbreak repeatedly after the drug withdrawal.Learn it with left side, the crown through inquiry, eye socket pain is difficult to stand most.During headache,, belong to headache caused by pathogenic wind category, i.e. migraine through analysis according to patient's disease often with the nausea and vomiting symptom; Take 5 days dosage of embodiments of the invention l capsule, pain relief after further consultation after 5 days, patient's private prosecution were taken medicine back 20 minutes has not had the headache symptom during check.Doctor's advice patient takes capsule of the present invention 3 days again to consolidate curative effect.Phone inquiry after half a year does not have recurrence.
2. Zhang, the man, 23 years old, with ictal dim eyesight, the headache prescription on individual diagnosis that is chief complaint in 5 years.Dim eyesight appearred in the no obvious inducement of elder generation before the patient had a headache at every turn and shows effect, and felt dizzy, and continued about 10 minutes; And then headache appears, and be main with both sides temples jumping pain, pain degree is heavier; Activity can make headache increase the weight of, and with nausea and vomiting, each duration of seizure continues about 4 hours; Sleep back headache remission or alleviate shows effect weekly 1 time recently.Diagnosis: classical migraine.Take 7 days dosage of embodiments of the invention 2 capsules, further consultation after 7 days, patient's private prosecution were taken medicine back 30 hours, and the headache sx has not had the headache symptom during check.Doctor's advice patient takes capsule of the present invention 7 days again to consolidate curative effect.Phone inquiry after half a year does not have recurrence.
3. Liu, the woman, 30 years old, private prosecution suffered from headaches and had a surplus in 3 years, increased the weight of when not having enough sleep especially, and medicines such as brain spirit element, carbamazepine, Thebe woods, sodium valproate were taken in private prosecution, but curative effect is not obvious, and the state of an illness increases the weight of the prescription on individual diagnosis of coming recently.Be after diagnosing: angioneurotic headache, take embodiments of the invention 4 capsules 5 daily doses, further consultation after 5 days has not had the headache symptom during check.Doctor's advice patient takes capsule of the present invention 2 days again to consolidate curative effect; Phone inquiry after March does not have recurrence.
4. tall certain, the woman, 25 years old, private prosecution suffered from headaches 4 years, often outbreak, the outbreak cycle is fixing, during outbreak, left side head twinge, pulse appearance is jumped painful, often with nausea and vomiting, it is multiple to take Western medicine, but curative effect is not obvious.CT examination is no abnormal.Be diagnosed as classical migraine, take embodiments of the invention 1 capsule 7 daily doses, further consultation after 7 days has not had the headache symptom during check.Doctor's advice patient takes capsule of the present invention 7 days again to consolidate curative effect; Phone inquiry after 6 months does not have recurrence.
The present invention treats migrainous pharmaceutical composition on probation through 2 years clinically, and evident in efficacy, the number of participating in the experiment is totally 208 people; Oldest 71 years old, minimum 18 years old, wherein female patient about 54%; Male patient about 46%, 80% patient can fully recover a course of treatment, and the only a few needs of patients is taken two courses of treatment and can be fully recovered; Total effective rate can reach more than 92%, and wherein 95% above patient did not have recurrence in 1 year.
The specific embodiment
Through following FORMULATION EXAMPLE the present invention is described in more detail at present, but does not limit the present invention in any form.
EXAMPLE l: weighting raw materials material Rhizoma Chuanxiong 40g, Fructus Piperis Longi 18g, Radix Angelicae Sinensis 20g, Herba Asari 30g, Radix Angelicae Dahuricae 22g, windproof 18g, Camphora 1g, Flos Chrysanthemi 14g; Clean, dry, pulverize, cross 80 mesh sieves; Sterilize through ultraviolet; Insert capsule then No. 0, adorn about 0. 5g, promptly get capsule of the present invention for every.
Embodiment 2: weighting raw materials material Rhizoma Chuanxiong 30g, Fructus Piperis Longi 20g, Radix Angelicae Sinensis 30g, Herba Asari 24g, Radix Angelicae Dahuricae 30g, windproof 20g, Camphora 2g, Flos Chrysanthemi 15g; Clean, dry, pulverize, cross 80 mesh sieves; Sterilize through ultraviolet; Insert capsule then No. 0, adorn about 0. 5g, promptly get capsule of the present invention for every.
Embodiment 3: weighting raw materials material Rhizoma Chuanxiong 60g, Fructus Piperis Longi 10g, Radix Angelicae Sinensis 50g, Herba Asari 30g, Radix Angelicae Dahuricae 18g, windproof 15g, Camphora 2g, Flos Chrysanthemi 20g; Clean, dry, pulverize, cross 80 mesh sieves; Sterilize through ultraviolet; Insert capsule then No. 0, adorn about 0. 5g, promptly get capsule of the present invention for every.
Embodiment 4: weighting raw materials material Rhizoma Chuanxiong 45g, Fructus Piperis Longi 23g, Radix Angelicae Sinensis 34g, Herba Asari 40g, Radix Angelicae Dahuricae 35g, windproof 28g, Camphora 5g, Flos Chrysanthemi 18g; Clean, dry, pulverize, cross 80 mesh sieves; Sterilize through ultraviolet; Insert capsule then No. 0, adorn about 0. 5g, promptly get capsule of the present invention for every.
Claims (4)
1. the migrainous pharmaceutical composition of treatment is characterized in that being processed by the raw material of following weight portion: Rhizoma Chuanxiong 30-60 part, Fructus Piperis Longi 10-25 part, Radix Angelicae Sinensis 20-50 part, Herba Asari 20-50 part, Radix Angelicae Dahuricae 18-40 part, windproof 15-30 part, Camphora 1-5 part, Flos Chrysanthemi 10-20 part.
2. like the migrainous pharmaceutical composition of the described treatment of claim l, it is characterized in that processing: 40 parts of Rhizoma Chuanxiongs, 18 parts of Fructus Piperis Longi, 20 parts of Radix Angelicae Sinensis, 30 parts of Herba Asaris, 22 parts of the Radixs Angelicae Dahuricae, windproof 18 parts, 1 part of Camphora, 14 parts of Flos Chrysanthemis by the raw material of following weight portion.
3. the migrainous pharmaceutical composition of treatment as claimed in claim 2 is characterized in that: said pharmaceutical composition is a peroral dosage form.
4. the migrainous pharmaceutical composition of treatment as claimed in claim 3 is characterized in that: said peroral dosage form is a capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104147386A (en) * | 2014-08-13 | 2014-11-19 | 高丽丽 | Traditional Chinese medicinal preparation for treating migraine and preparation method thereof |
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