CN102552416A - Traditional Chinese medicine granule for treating metabolic syndrome and habitual constipation - Google Patents
Traditional Chinese medicine granule for treating metabolic syndrome and habitual constipation Download PDFInfo
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- CN102552416A CN102552416A CN2012100338184A CN201210033818A CN102552416A CN 102552416 A CN102552416 A CN 102552416A CN 2012100338184 A CN2012100338184 A CN 2012100338184A CN 201210033818 A CN201210033818 A CN 201210033818A CN 102552416 A CN102552416 A CN 102552416A
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Abstract
The invention relates to a traditional Chinese medicine granule for treating metabolic syndrome and habitual constipation, which belongs to the traditional Chinese medicine preparation field. The effective components of the granule is composed of 30-60 parts of lotus leaf, 10-12 parts of wild chrysanthemum flower and 10-12 parts of Rhodiola rosea by weight ratio. The traditional Chinese medicine granule has the advantages of short administration treatment course, high treatment efficiency and high cure rate, administration of four months treatment courses can obviously reduce the body weight, and the blood fat is normal, the atherosclerotic plaque is smaller and stable, the effective rate of treatment can reach 94%, the recovery rate can reach 88%, and the traditional Chinese medicine granule has the advantages of stable curative effect and difficult recurrence.
Description
Technical field
The present invention relates to a kind of Chinese medicine electuary of treating metabolism syndrome and habitual constipation, belong to field of traditional Chinese.
Background technology
Metabolism syndrome (metabolic syndrome; MS) be one group with obesity, hyperglycemia (diabetes or IGR), dyslipidemia (refer to hypertriglyceridemia and/or low-density lipoprotein cholesterol mass formed by blood stasis and hypertension etc. assemble morbidity); Have a strong impact on the clinical syndrome of body health; Be the combination of one group of risk factor that in metabolism, is mutually related, these factors have directly promoted the generation of atherosclerotic cardiovascular and cerebrovascular disease, have also increased the risk that type ii diabetes takes place.Result of study shows at present, and MS patient is the high-risk group that cardiovascular and cerebrovascular disease takes place, and compares with non-MS person, and its danger of suffering from cardiovascular and cerebrovascular disease all significantly increases with the danger that type ii diabetes takes place.The morbidity of MS is the process of chronic a, progressivity; As easy as rolling off a log being failed to pinpoint a disease in diagnosis in clinical position; Get into the intermediary and later stages mostly when coming to light by the time: concomitant diseases such as type ii diabetes, CKD, cardiovascular disease (like coronary heart disease, atherosclerosis etc.), hypertension have all occurred, cause the treatment of MS difficult more.Along with the acceleration of global aging, the prevalence of MS is ascendant trend year by year in recent years, and MS has become one of healthy main disease of modern society's harm humans, and the research of relevant MS also receives various countries scholar's attention.Habitual constipation is meant secular, chronic functional constipation.The reason such as change and psychological factor that mainly is life, diet and bowl evacuation habit causes, and relies on cathartic for a long time and only can increase the weight of the constipation degree gradually.The reason that hyperlipemia occurs is that toxin is too much; Toxin in the blood vessel comprises too much saturated fat class, too much monosaccharide, too much chemical substance etc., and these materials are angiosclerotic beginnings in the deposition of blood vessel wall; Deleterious material constantly deposits, body lacks enough abilities and removes these toxin; Blood vessel is constantly encroached on, and keeps in repair but can not get enough protective materials, has just formed sclerosis with the passage of time.Therefore, the method for solution needs to set about from root.
Summary of the invention
The technical problem that the present invention will solve is: overcome the deficiency of prior art, a kind of Chinese medicine electuary of treating metabolism syndrome and habitual constipation is provided, this Chinese medicine electuary taking convenience, and short treating period have no side effect, and are easy to accepted by the patient.
The technical solution adopted for the present invention to solve the technical problems is: the Chinese medicine electuary of treatment metabolism syndrome and habitual constipation; It is characterized in that; The raw material of this effective ingredient is made up of Folium Nelumbinis, Flos Chrysanthemi Indici and Radix Rhodiolae; Its weight proportion is 30～60 parts on a Folium Nelumbinis, 10～12 parts of Flos Chrysanthemi Indicis, 10～12 parts of Radix Rhodiolaes.
Preferably, the raw material of this effective ingredient composition and weight proportion thereof are: 50 parts on Folium Nelumbinis, 10 parts of Flos Chrysanthemi Indicis, 12 parts of Radix Rhodiolaes.
Among the present invention, each main effect of forming medicine is following: Folium Nelumbinis contains nuciferine, miltanthin and nuciferine and vitamin C, polysaccharide, bitter and puckery flavor; Folium Nelumbinis property is flat, function heat-clearing and toxic substances removing, sending up the lucid YANG, the effect of cooling blood for hemostasis.Flos Chrysanthemi Indici contains multiple volatile oil, comprises lauro lene, Eucarvone, limonene, also contains linarin, luteolin glycoside, Chrysanthemin, chrysanthemaxanthin, polysaccharide, Coumarins, yejuhua lactone; The Flos Chrysanthemi Indici cold nature, acrid in the mouth, hardship, the function heat-clearing and toxic substances removing, the dispelling wind suppressing the hyperactive liver, detumescence all has inhibitory action to staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, influenza virus.Radix Rhodiolae sweet in the mouth, hardship, property is flat, returns lung, heart channel.The function benefiting QI for activating blood circulation is promoted blood circulation and is relievingd asthma.Be used for blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia asthma.Radix Rhodiolae can improve the binding ability of hemoglobin and oxygen rapidly, improves blood oxygen saturation, reduces the oxygen consumption of body, increases exercise tolerance, and the back of recovering to move is tired.Radix Rhodiolae contains scopolamine, kaempferol, tannin; Can improve the nonspecific resistance of human body, strengthen the adaptability of human body, improve body anoxybiotic adaptive faculty to destructive stimulus; Suppress the generation of the radiation-induced heart and liver lipid peroxide, lipid and cell membrane are played a protective role.Radix Rhodiolae can significantly improve the activity of body superoxide dismutase, removes free radical, suppresses cylinder super-oxidation lipid and generates.
Preparation technology of the present invention, undertaken by following operation:
A) selected raw medicinal material Folium Nelumbinis, Flos Chrysanthemi Indici, Radix Rhodiolae, proportioning is put into the drying machine dried respectively according to the above ratio, and mix homogeneously gets raw medicinal material;
B) selected raw medicinal material is put into rotary medicine cutter respectively and be ground into fine powder, cross 300 mesh sieve holes, get the medical material fine powder;
C) Folium Nelumbinis fine powder input air flow formula super micron mill micronizing is distributed in 50～70 microns Folium Nelumbinis ultramicro powder more than 99% to particle diameter; Radix Rhodiolae fine powder input air flow formula super micron mill micronizing is distributed in 0～20 micron Radix Rhodiolae ultramicro powder more than 99% to particle diameter; Flos Chrysanthemi Indici through supercritical fluid extraction extract the Flos Chrysanthemi Indici extract powder; Its quality and crude drug fine powder mass ratio are 1: 10, extracting pressure 10MPa, 37～39 ℃ of extraction temperature;
D) with Folium Nelumbinis ultramicro powder, Radix Rhodiolae ultramicro powder, Flos Chrysanthemi Indici extract powder according to 30～60 parts on Folium Nelumbinis; 10～12 parts of Flos Chrysanthemi Indicis; The weight ratio that Radix Rhodiolae is 10～12 parts is mixed, and its mixed-powder is the Chinese medicine electuary that the present invention treats metabolism syndrome and habitual constipation.
The broken sporoderm-broken rate that improves crude drug cell of Chinese medicine ultra-fine powder, cell intracellular effective ingredient behind breaking cellular wall fully comes out, the rate of release and the burst size of medicine can significantly improve.Through micronizing processing, the ultramicro powder specific surface area is doubled and redoubled, and the surface charge of medicine, viscous force are changed, and makes it that fine solubility, dispersibility, adsorptivity, chemical reactivity arranged.The broken good mouthfeel of Chinese medicine electuary that both guaranteed of Chinese medicine ultra-fine powder guarantees that again effective ingredient is not destroyed, and more helps absorption by human body.
Compared with prior art; The beneficial effect that the Chinese medicine electuary of treatment metabolism syndrome of the present invention and habitual constipation is had is: the Chinese medicine electuary of treatment metabolism syndrome of the present invention and habitual constipation is promoted blood circulation through changing turbid heat clearing away, detoxifcation, the intestinal stasis relieving relieving constipation, to reach YIN and YANG balance regulating, balance internal organs, mediation blood vessels, improves metabolism state, blood lipid regulation, the atherosclerotic function of reverse; Make all diseases from disappearing; Lose weight, rate and blood-lipid decreased, defecation is normal.The present invention is the Chinese medicine electuary, and prescription is simple, and dissolving is rapid, and normal-temperature water is a solubilized, and only need take 2 every day, and taking convenience is without any side effects.The present invention treats effective percentage and cure rate is higher, and it is taken and gets final product produce effects 1 course of treatment (30 days), and blood fat reduces, defecation is normal; Take 4 the course of treatment state of an illness can reach body weight and obviously alleviate; Blood fat is normal, and atheromatous plaque dwindles and be stable, and the treatment effective percentage reaches 94%; Cure rate reaches 88%, stable curative effect and difficult recurrence.
The specific embodiment
Embodiment 1～5
The proportioning component of the Chinese medicine electuary of treatment metabolism syndrome of the present invention and habitual constipation is as shown in table 1, and wherein embodiment 3 is a most preferred embodiment.
The Chinese medicine electuary (in weight portion) of table 1 embodiment 1～5 treatment metabolism syndrome and habitual constipation
Concrete preparation technology is following:
A) selected raw medicinal material Folium Nelumbinis, Flos Chrysanthemi Indici, Radix Rhodiolae, proportioning is put into the drying machine dried respectively according to the above ratio, and mix homogeneously gets raw medicinal material;
B) selected raw medicinal material is put into rotary medicine cutter respectively and be ground into fine powder, cross 300 mesh sieve holes, get the medical material fine powder;
C) Folium Nelumbinis fine powder input air flow formula super micron mill micronizing is distributed in 50～70 microns Folium Nelumbinis ultramicro powder more than 99% to particle diameter; Radix Rhodiolae fine powder input air flow formula super micron mill micronizing is distributed in 0～20 micron Radix Rhodiolae ultramicro powder more than 99% to particle diameter; Flos Chrysanthemi Indici through supercritical fluid extraction extract the Flos Chrysanthemi Indici extract powder; Its quality and crude drug fine powder mass ratio are 1: 10, extracting pressure 10MPa, 37～39 ℃ of extraction temperature;
D) with Folium Nelumbinis ultramicro powder, Radix Rhodiolae ultramicro powder, Flos Chrysanthemi Indici extract powder according to 30～60 parts on Folium Nelumbinis; 10～12 parts of Flos Chrysanthemi Indicis; The weight ratio that Radix Rhodiolae is 10～12 parts is mixed, and its mixed-powder is the Chinese medicine electuary that the present invention treats metabolism syndrome and habitual constipation.
Clinical practice of the present invention is summed up as follows:
The Chinese medicine electuary of this treatment metabolism syndrome and habitual constipation, ante cibum, warm water was taken after mixing it with water, and took 2 times in 1 day, once took 15 grams, and taking 30 days continuously is 1 course of treatment.
Through the 25248 routine patients that take Tonghua of the present invention ball are carried out clinical observation, the result is following: total case load 21176 examples, and male patient's 13172 examples wherein, female patient accounts for 8004.Minimal ages 18 years old, maximum age 75 years old, the patient that 45 years old or following patient accounted for 64.9%, 46～60 years old accounts for and accounted for 11.6% in 23.5%, 60 years old～75 years old.
Simple Obesity patient's cardinal symptom: bad figure, handicapped, To Be Protected from Heat, causes heatstroke and heat collapse, and the endurance difference is prone to wound.
Habitual constipation patient cardinal symptom: defecation is less than 3 times weekly, and defecation is often felt difficulty, and complexion dusk is dim, too fat to move, presents unusual ill face.
Metabolism syndrome patient cardinal symptom: abdominal obesity or overweight; Atherogenicity, dyslipidemia [high triglyceride (TG) mass formed by blood stasis and HDL-C (HDL-C) are low]; Hypertension; Insulin resistant and/or impaired glucose tolerance, short inflammatory conditions (C-reactive protein CRP) increase and short thrombosis state (Fibrinogen increases and plasminogen mortifier-1, PAI-1) increases.
The hyperlipemia cardinal symptom: the intra-arterial face has the lipid striped, forms AP, angiostenosis, organ ischemia, and hypomnesis, dizziness, headache, cholesterolemia, triglyceride increase, and high density lipoprotein lowers, and the LEP figure is unusual.
Curative effect judging standard: the improvement situation according to above-mentioned symptom is divided into recovery from illness, produce effects and invalid with curative effect; Take in 4 courses of treatment, whole disappearances of above-mentioned symptom or alleviation are recovery from illness, and part disappears or alleviation is produce effects; All the other are invalid, and total effective rate is obvious effective rate and cure rate sum.Oral Chinese medicine electuary warm water ante cibum of the present invention of patient is taken after mixing it with water, and once takes 15 grams every day 2 times, and taking 30 days continuously is 1 course of treatment, takes Chinese medicine electuary according to the invention continuously and adds up after 4 courses of treatment, and statistical result is as shown in table 1:
Table 1 is taken the case statistics of the Chinese medicine electuary of treatment metabolism syndrome of the present invention and habitual constipation
As shown in table 1, total effective 21176 examples, 18589 examples of fully recovering, produce effects 1394 examples are taken in 4 courses of treatment effective percentage 94%, cure rate 88%.
Model case
Liu, the man, 65 years old, on November 9th, 2009 owed flexible half a year surplus examining because of the right side limb activity.Patient's right side limb activity that broke out before half a year is unfavorable, is difficult to walking, takes a turn for the better through hospitalization and leaves hospital, and it is unfavorable to leave over the right side limb activity, and numb limbs and tense tendons is uncomfortable, and speech is stuttering puckery, no stupor, vomiting and nausea, diplopia etc.Receive sleep can, constipation, urine is transferred.Dimly red tongue, tongue is white, stringy and hesitant pulse.Previously have surplus the hypertension history 10 year, hyperlipemia 7 years is surplus.Have a medical check-up: Bp:165/105mmHg, right side upper and lower extremities muscular strength 4+ level, muscular tension is low.Auxiliary examination: left side basal ganglia region lacunar infarction is shown in the inspection of cranium brain magnetic resonance.Serum low-density LP cholesterol: 4.57mmol/l, cholesterol 6.39mmol/l, triglyceride: 2.46mmol/l.Tentative diagnosis: tcm diagnosis: apoplexy (resistance of the wind-phlegm stasis of blood), Western medicine diagnose: 1. cerebral infarction sequela 2. hyperlipemias.Give treatments such as antiplatelet aggregation, stabilize plaque, neuroprotective, and give the clear granule of arteries and veins and take after mixing it with water, each 15g, every day 2 times; Patient's state of an illness obviously alleviates and leaves hospital after 24 days, and the right side limb activity is more preceding strong flexibly, and speech is normal basically, the dizzy improvement; Free movement of the bowels, routine is taken Aspirin Enteric-coated Tablets after leaving hospital, the simvastatin sheet is oral, and the clear granule of arteries and veins is taken after mixing it with water further consultation after February; Last disease obviously alleviates, and the right side limbs do not have numb unfavorable sensation basically, and dizziness alleviates; Check: low-density lipoprotein cholesterol: 2.66mmol/l, cholesterol: 4.38mmol/l, triglyceride: 1.53mmol/l; The carotid artery color Doppler echocardiography shows that the common carotid artery AP obviously dwindles, and is stable speckle.
Zhang, the man 42 years old, examines on May 10th, 2010 because of fat gradually 5 years of body is surplus.This patient has a liking for the food delicious food usually, and is heavy, the time have headache uncomfortable, does not have symptom and signs such as dizzy, uncomfortable in chest, the past does not have family's obesity history, no family hypertension history.Have a medical check-up: height 172cm, body weight 98kg, 130 centimetres of abdominal circumferences, blood pressure 165/100mmHg, patient's body is the uniformity obesity; Often have vertigo and tinnitus concurrently, it is unfavorable that limbs heavily stagnate, and coughs and tell the sticky thin foam expectorant of a large amount of whites, and expectorant goes out then spirit and QI cleaning; Xerostomia desire drink, pale tongue is dark, white and greasy fur, pulse condition is heavy sliding.Auxiliary examination: endocrine, hepatic and renal function, cardio-pulmonary function etc. are all normal.Tentative diagnosis: tcm diagnosis: fat (containing in the phlegm-damp), Western medicine diagnose: Simple Obesity.Give the clear granule of arteries and veins and take after mixing it with water, each 15g, took 3 months continuously at every day 2 times.Further consultation on August 16 in 2010, shape fertilizer subtracts, and abdominal circumference is little, dizzy alleviating, expectoration reduces, matter thickness, malaise symptoms such as no weak, asthenia, Mental fatigue.Tongue arteries and veins such as preceding.Have a medical check-up: body weight is kept to 82kg, and blood pressure is reduced to 135/80mmHg, and continue to take the clear granule of arteries and veins and take after mixing it with water, 1 dose of day, take February continuously, losing weight is 73kg, 90 centimetres of abdominal circumferences, blood pressure is normal.
Summer, the man, 50 years old, because of 10 years surplus examining of prolonged constipation, previously life style was irregular, and constipation with dry stool is not all right; The abdominal distention and pain tenderness is taken charthartic for a long time, distention and pain in the lower abdomen after an action of the bowels, sleep disorder, xerostomia halitosis; Flushing vexed, oliguria with reddish urine, red tongue, thick and greasy fur, stringy and rolling pulse and the right side is bigger.Tentative diagnosis: tcm diagnosis: constipation (the intestinal internal organs is scorching), Western medicine diagnose: constipation.Give the clear granule of arteries and veins and take after mixing it with water, each 15g, every day 2 times, continuous 10 doses, stool is profit gradually, and the abdominal part distending pain reduces by half.Continue and obey 6 doses, the abdominal part distending pain disappears.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (3)
1. Chinese medicine electuary of treating metabolism syndrome and habitual constipation, it is characterized in that: the raw material of this effective ingredient is made up of Folium Nelumbinis, Flos Chrysanthemi Indici and Radix Rhodiolae, and its weight proportion is 30～60 parts on a Folium Nelumbinis, 10～12 parts of Flos Chrysanthemi Indicis, 10～12 parts of Radix Rhodiolaes.
2. a kind of Chinese medicine electuary of treating metabolism syndrome and habitual constipation according to claim 1 is characterized in that, the raw material of this effective ingredient is formed and weight proportion is: 50 parts on Folium Nelumbinis, 10 parts of Flos Chrysanthemi Indicis, 12 parts of Radix Rhodiolaes.
3. preparation a kind of method of treating the Chinese medicine electuary of metabolism syndrome and habitual constipation according to claim 1 or claim 2 is characterized in that, comprises the steps:
A) selected raw medicinal material Folium Nelumbinis, Flos Chrysanthemi Indici, Radix Rhodiolae, proportioning is put into the drying machine dried respectively according to the above ratio, and mix homogeneously gets raw medicinal material;
B) selected raw medicinal material is put into rotary medicine cutter respectively and be ground into fine powder, cross 300 mesh sieve holes, get the medical material fine powder;
C) Folium Nelumbinis fine powder input air flow formula super micron mill micronizing is distributed in 50～70 microns Folium Nelumbinis ultramicro powder more than 99% to particle diameter; Radix Rhodiolae fine powder input air flow formula super micron mill micronizing is distributed in 0～20 micron Radix Rhodiolae ultramicro powder more than 99% to particle diameter; Flos Chrysanthemi Indici through supercritical fluid extraction extract the Flos Chrysanthemi Indici extract powder; Its quality and crude drug fine powder mass ratio are 1: 10, extracting pressure 10MPa, 37～39 ℃ of extraction temperature;
D) with Folium Nelumbinis ultramicro powder, Radix Rhodiolae ultramicro powder, Flos Chrysanthemi Indici extract powder according to 30～60 parts on Folium Nelumbinis; 10～12 parts of Flos Chrysanthemi Indicis; The weight ratio that Radix Rhodiolae is 10～12 parts is mixed, and its mixed-powder is the Chinese medicine electuary that the present invention treats metabolism syndrome and habitual constipation.
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| KR20100074738A (en) * | 2008-12-24 | 2010-07-02 | 호서대학교 산학협력단 | Herbal extract for prevention or treatment of inflammatory diseases and pharmaceutical composition and functional food containing the same |
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