CN102552119B - 一种盐酸氨溴索葡萄糖注射液及其制备方法 - Google Patents
一种盐酸氨溴索葡萄糖注射液及其制备方法 Download PDFInfo
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- CN102552119B CN102552119B CN 201010611335 CN201010611335A CN102552119B CN 102552119 B CN102552119 B CN 102552119B CN 201010611335 CN201010611335 CN 201010611335 CN 201010611335 A CN201010611335 A CN 201010611335A CN 102552119 B CN102552119 B CN 102552119B
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- injection
- ambroxol hydrochloride
- glucose
- add
- filtrate
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- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 title claims abstract description 59
- 229960000985 ambroxol hydrochloride Drugs 0.000 title claims abstract description 59
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 229940093181 glucose injection Drugs 0.000 title claims abstract description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000008215 water for injection Substances 0.000 claims abstract description 33
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 28
- 239000000706 filtrate Substances 0.000 claims abstract description 23
- 239000008103 glucose Substances 0.000 claims abstract description 23
- 229940090044 injection Drugs 0.000 claims abstract description 14
- 238000002347 injection Methods 0.000 claims abstract description 14
- 239000007924 injection Substances 0.000 claims abstract description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 12
- 239000000498 cooling water Substances 0.000 claims abstract description 11
- 239000012528 membrane Substances 0.000 claims abstract description 11
- 230000001954 sterilising effect Effects 0.000 claims abstract description 11
- 239000007788 liquid Substances 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000004568 cement Substances 0.000 claims description 10
- 239000003610 charcoal Substances 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 8
- 239000000047 product Substances 0.000 abstract description 11
- 239000000243 solution Substances 0.000 abstract description 3
- 239000003381 stabilizer Substances 0.000 abstract description 2
- 238000007865 diluting Methods 0.000 abstract 2
- 238000004026 adhesive bonding Methods 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 229910001873 dinitrogen Inorganic materials 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000007789 sealing Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 14
- 239000000126 substance Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 206010036790 Productive cough Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000013068 control sample Substances 0.000 description 4
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 239000006174 pH buffer Substances 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 208000035939 Alveolitis allergic Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 description 1
- 208000024711 extrinsic asthma Diseases 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN 201010611335 CN102552119B (zh) | 2010-12-28 | 2010-12-28 | 一种盐酸氨溴索葡萄糖注射液及其制备方法 |
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CN 201010611335 CN102552119B (zh) | 2010-12-28 | 2010-12-28 | 一种盐酸氨溴索葡萄糖注射液及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102552119A CN102552119A (zh) | 2012-07-11 |
CN102552119B true CN102552119B (zh) | 2013-08-07 |
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CN 201010611335 Active CN102552119B (zh) | 2010-12-28 | 2010-12-28 | 一种盐酸氨溴索葡萄糖注射液及其制备方法 |
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Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103006548B (zh) * | 2011-09-28 | 2015-10-07 | 四川科伦药物研究有限公司 | 一种盐酸氨溴索葡萄糖注射液及其制备方法 |
CN103330681B (zh) * | 2013-07-09 | 2016-07-06 | 四川科伦药业股份有限公司 | 一种灭菌前的多室输液袋的内袋中的葡萄糖注射液及其制备方法 |
CN105675523A (zh) * | 2014-11-17 | 2016-06-15 | 蚌埠丰原涂山制药有限公司 | 一种氨溴索含量紫外分光光度测定方法 |
CN104887622A (zh) * | 2015-06-08 | 2015-09-09 | 安徽双鹤药业有限责任公司 | 一种稳定的盐酸氨溴索大容量注射液及其制备方法 |
CN106074373A (zh) * | 2016-08-18 | 2016-11-09 | 黑龙江中桂制药有限公司 | 一种盐酸氨溴索葡萄糖注射液的制备方法 |
CN110151688A (zh) * | 2019-05-17 | 2019-08-23 | 石家庄学院 | 一种盐酸氨溴索注射液组合物及其制备方法 |
CN110227063B (zh) * | 2019-06-18 | 2021-06-15 | 石药银湖制药有限公司 | 一种利奈唑胺注射液的制备方法 |
CN112891300B (zh) * | 2021-01-28 | 2022-03-15 | 朗天药业(湖北)有限公司 | 一种盐酸氨溴索注射液及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101416956A (zh) * | 2007-10-22 | 2009-04-29 | 天津康鸿医药科技发展有限公司 | 一种盐酸氨溴索注射剂 |
CN101627967A (zh) * | 2009-08-03 | 2010-01-20 | 上海华源药业(宁夏)沙赛制药有限公司 | 盐酸氨溴索液体制剂及其制备方法 |
Family Cites Families (1)
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DE10303229B4 (de) * | 2003-01-28 | 2007-07-26 | Keyneurotek Ag | Ambroxol und Inhibitoren des Angiotensin Converting-Enzyms (ACE) umfassende Arzneimittel Arzneimittel-Zubereitung und ihre Verwendung zur Behandlung von neurodegenerativen Erkrankungen |
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2010
- 2010-12-28 CN CN 201010611335 patent/CN102552119B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101416956A (zh) * | 2007-10-22 | 2009-04-29 | 天津康鸿医药科技发展有限公司 | 一种盐酸氨溴索注射剂 |
CN101627967A (zh) * | 2009-08-03 | 2010-01-20 | 上海华源药业(宁夏)沙赛制药有限公司 | 盐酸氨溴索液体制剂及其制备方法 |
Non-Patent Citations (2)
Title |
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注射用盐酸氨溴索溶解方法及与常用药物配伍稳定性考察;赵志刚等;《药品评价》;20100328;第7卷(第6期);第46-48页 * |
赵志刚等.注射用盐酸氨溴索溶解方法及与常用药物配伍稳定性考察.《药品评价》.2010,第7卷(第6期),第46-48页. |
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Address after: 611138 Sichuan science and Technology Development Zone, Wenjiang District, Chengdu City, Xinhua Road, the central section of the two paragraph Patentee after: SICHUAN KELUN DRUG RESEARCH INSTITUTE CO., LTD. Address before: 610500 Sichuan province Chengdu City satellite city industrial development zone two South Road Patentee before: Kelun Pharmaceutical Research Co., Ltd. |