CN102549432B - 用于软组织疾病诊断和作为口腔护理干预的治疗性靶标的蛋白质生物标记 - Google Patents

用于软组织疾病诊断和作为口腔护理干预的治疗性靶标的蛋白质生物标记 Download PDF

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Publication number
CN102549432B
CN102549432B CN201080015874.4A CN201080015874A CN102549432B CN 102549432 B CN102549432 B CN 102549432B CN 201080015874 A CN201080015874 A CN 201080015874A CN 102549432 B CN102549432 B CN 102549432B
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mmp
biomarker
biomarkers
sample
periodontal disease
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Chinese (zh)
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CN102549432A (zh
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H·M·特里维迪
徐韬
杨英
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Colgate Palmolive Co
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Colgate Palmolive Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56955—Bacteria involved in periodontal diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080015874.4A 2009-04-01 2010-04-01 用于软组织疾病诊断和作为口腔护理干预的治疗性靶标的蛋白质生物标记 Expired - Fee Related CN102549432B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16567409P 2009-04-01 2009-04-01
US61/165674 2009-04-01
PCT/US2010/029674 WO2010115034A2 (en) 2009-04-01 2010-04-01 Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention

Publications (2)

Publication Number Publication Date
CN102549432A CN102549432A (zh) 2012-07-04
CN102549432B true CN102549432B (zh) 2015-03-25

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Country Status (15)

Country Link
US (1) US8753820B2 (https=)
EP (1) EP2414837B1 (https=)
JP (1) JP5643288B2 (https=)
CN (1) CN102549432B (https=)
AR (1) AR076041A1 (https=)
BR (1) BRPI1013184A2 (https=)
CA (1) CA2753718C (https=)
CO (1) CO6430490A2 (https=)
MX (1) MX2011008439A (https=)
MY (1) MY179250A (https=)
RU (1) RU2523383C2 (https=)
SG (1) SG173461A1 (https=)
TW (1) TWI481870B (https=)
WO (1) WO2010115034A2 (https=)
ZA (1) ZA201106056B (https=)

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TWI405565B (zh) * 2009-04-01 2013-08-21 Colgate Palmolive Co 口腔用組成物之抗－骨質流失及抗－牙周附連喪失之功效
US9949671B2 (en) 2013-03-13 2018-04-24 Orthoaccel Technologies, Inc. Diagnostic mouthpieces
US20190339269A1 (en) * 2017-01-03 2019-11-07 The Trustees Of The University Of Pennsylvania Compositions and methods for predicting risk of preterm birth
EP3631462A1 (en) * 2017-05-24 2020-04-08 Koninklijke Philips N.V. Diagnostics of gingivitis based on salivary il-1beta and hgf
JP7245174B2 (ja) * 2017-05-24 2023-03-23 コーニンクレッカ フィリップス エヌ ヴェ 唾液のｈｇｆ及びｍｍｐ－８に基づく歯周炎の診断
JP7486316B2 (ja) 2017-05-24 2024-05-17 コーニンクレッカ フィリップス エヌ ヴェ 唾液のｉｌ－１ベータ及びｍｍｐ－９に基づく軽度の又は進行した歯周炎の診断
CN111226118A (zh) 2017-10-27 2020-06-02 加利福尼亚大学董事会 用于牙龈炎的唾液细胞外rna生物标记物
EP3477306A1 (en) * 2017-10-30 2019-05-01 Koninklijke Philips N.V. Classification of periodontitis patients

Citations (1)

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Publication number Publication date
JP5643288B2 (ja) 2014-12-17
WO2010115034A3 (en) 2010-12-29
CA2753718C (en) 2015-06-23
JP2012522994A (ja) 2012-09-27
CN102549432A (zh) 2012-07-04
TWI481870B (zh) 2015-04-21
RU2011144032A (ru) 2013-05-10
US8753820B2 (en) 2014-06-17
EP2414837B1 (en) 2015-06-03
BRPI1013184A2 (pt) 2016-04-12
AR076041A1 (es) 2011-05-11
EP2414837A2 (en) 2012-02-08
SG173461A1 (en) 2011-09-29
MY179250A (en) 2020-11-02
TW201102653A (en) 2011-01-16
CA2753718A1 (en) 2010-10-07
MX2011008439A (es) 2011-09-06
ZA201106056B (en) 2015-05-27
CO6430490A2 (es) 2012-04-30
US20120028261A1 (en) 2012-02-02
RU2523383C2 (ru) 2014-07-20
AU2010232593A1 (en) 2011-08-25
WO2010115034A2 (en) 2010-10-07

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