CN102527453A - 一种应用于纳米颗粒制备的高并行微流道芯片 - Google Patents
一种应用于纳米颗粒制备的高并行微流道芯片 Download PDFInfo
- Publication number
- CN102527453A CN102527453A CN2011104543450A CN201110454345A CN102527453A CN 102527453 A CN102527453 A CN 102527453A CN 2011104543450 A CN2011104543450 A CN 2011104543450A CN 201110454345 A CN201110454345 A CN 201110454345A CN 102527453 A CN102527453 A CN 102527453A
- Authority
- CN
- China
- Prior art keywords
- pdms
- runner
- microns
- layer
- intermediate layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Description
Claims (14)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110454345.0A CN102527453B (zh) | 2011-12-30 | 2011-12-30 | 一种应用于纳米颗粒制备的高并行微流道芯片 |
PCT/CN2012/000330 WO2013097262A1 (zh) | 2011-12-30 | 2012-03-16 | 一种应用于纳米颗粒制备的高并行微流道芯片 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110454345.0A CN102527453B (zh) | 2011-12-30 | 2011-12-30 | 一种应用于纳米颗粒制备的高并行微流道芯片 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102527453A true CN102527453A (zh) | 2012-07-04 |
CN102527453B CN102527453B (zh) | 2014-03-12 |
Family
ID=46336196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110454345.0A Expired - Fee Related CN102527453B (zh) | 2011-12-30 | 2011-12-30 | 一种应用于纳米颗粒制备的高并行微流道芯片 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN102527453B (zh) |
WO (1) | WO2013097262A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103055981A (zh) * | 2012-12-31 | 2013-04-24 | 苏州汶颢芯片科技有限公司 | 一种聚二甲基硅氧烷微流控芯片及其制备方法 |
CN104107734A (zh) * | 2014-07-18 | 2014-10-22 | 华南师范大学 | 一种微流控芯片及自组装的方法 |
CN104225964A (zh) * | 2014-09-17 | 2014-12-24 | 清华大学 | 微流体气泡排除装置及其制备方法以及微流体器件 |
CN109475861A (zh) * | 2016-03-28 | 2019-03-15 | 纳米免疫技术公司 | 基于金属纳米颗粒的光热转换特性检测分析物的微流控 |
CN114950582A (zh) * | 2022-04-20 | 2022-08-30 | 南京工业大学 | 一种用于合成纳米颗粒的微流控芯片装置及其应用 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021225599A1 (en) * | 2020-05-08 | 2021-11-11 | Hewlett-Packard Development Company, L.P. | Fluid structure formation via removing sacrificial structures |
CN112641957B (zh) * | 2020-12-31 | 2023-03-14 | 山西铁居环保科技有限公司 | 基于微流控芯片的嵌段共聚物PCL-b-PEO自组装包封金纳米粒的方法 |
CN114849800B (zh) * | 2022-04-15 | 2023-09-29 | 华东师范大学 | 微流控芯片及制备方法和氧化锌纳米棒阵列图案化生长的应用 |
CN116425190B (zh) * | 2023-04-04 | 2024-04-12 | 华东师范大学 | 一种基于微流控芯片原位生长氧化锌纳米棒的方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6210986B1 (en) * | 1999-09-23 | 2001-04-03 | Sandia Corporation | Microfluidic channel fabrication method |
JP2005334874A (ja) * | 2004-04-30 | 2005-12-08 | Sharp Corp | マイクロチャネルとその製造方法およびマイクロシステム |
CN101108721A (zh) * | 2007-06-15 | 2008-01-23 | 中国科学院上海微系统与信息技术研究所 | 一种磁性微结构的制作方法 |
CN101187718A (zh) * | 2007-12-07 | 2008-05-28 | 南京邮电大学 | 电控光开关阵列微流控芯片的制作方法 |
CN101544351A (zh) * | 2009-05-08 | 2009-09-30 | 东南大学 | 低维纳米材料高柔性组装芯片及应用方法 |
CN202538793U (zh) * | 2011-12-30 | 2012-11-21 | 北京瑞斯诺生物医药技术有限公司 | 一种应用于纳米颗粒制备的高并行微流道芯片 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6167910B1 (en) * | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
CN101629143B (zh) * | 2008-12-02 | 2011-09-21 | 中国科学院上海微系统与信息技术研究所 | 用于高通量药物筛选的微流控细胞阵列芯片、方法及应用 |
CN101823686B (zh) * | 2010-04-21 | 2012-07-04 | 大连理工大学 | 一种热塑性聚合物多层微流控芯片封合方法 |
-
2011
- 2011-12-30 CN CN201110454345.0A patent/CN102527453B/zh not_active Expired - Fee Related
-
2012
- 2012-03-16 WO PCT/CN2012/000330 patent/WO2013097262A1/zh active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6210986B1 (en) * | 1999-09-23 | 2001-04-03 | Sandia Corporation | Microfluidic channel fabrication method |
JP2005334874A (ja) * | 2004-04-30 | 2005-12-08 | Sharp Corp | マイクロチャネルとその製造方法およびマイクロシステム |
CN101108721A (zh) * | 2007-06-15 | 2008-01-23 | 中国科学院上海微系统与信息技术研究所 | 一种磁性微结构的制作方法 |
CN101187718A (zh) * | 2007-12-07 | 2008-05-28 | 南京邮电大学 | 电控光开关阵列微流控芯片的制作方法 |
CN101544351A (zh) * | 2009-05-08 | 2009-09-30 | 东南大学 | 低维纳米材料高柔性组装芯片及应用方法 |
CN202538793U (zh) * | 2011-12-30 | 2012-11-21 | 北京瑞斯诺生物医药技术有限公司 | 一种应用于纳米颗粒制备的高并行微流道芯片 |
Non-Patent Citations (3)
Title |
---|
20110222 Minsoung Rhee et al. Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels 79-83 1-14 , * |
MINSOUNG RHEE ET AL.: "Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels", <ADV. MATER.> * |
ROHIT KARNIK ET AL.: "Microfluidic Platform for Controlled", 《NANO LETTERS》 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103055981A (zh) * | 2012-12-31 | 2013-04-24 | 苏州汶颢芯片科技有限公司 | 一种聚二甲基硅氧烷微流控芯片及其制备方法 |
CN104107734A (zh) * | 2014-07-18 | 2014-10-22 | 华南师范大学 | 一种微流控芯片及自组装的方法 |
CN104107734B (zh) * | 2014-07-18 | 2016-03-02 | 华南师范大学 | 一种微流控芯片及自组装的方法 |
CN104225964A (zh) * | 2014-09-17 | 2014-12-24 | 清华大学 | 微流体气泡排除装置及其制备方法以及微流体器件 |
CN104225964B (zh) * | 2014-09-17 | 2016-09-28 | 清华大学 | 微流体气泡排除装置及其制备方法以及微流体器件 |
CN109475861A (zh) * | 2016-03-28 | 2019-03-15 | 纳米免疫技术公司 | 基于金属纳米颗粒的光热转换特性检测分析物的微流控 |
CN114950582A (zh) * | 2022-04-20 | 2022-08-30 | 南京工业大学 | 一种用于合成纳米颗粒的微流控芯片装置及其应用 |
CN114950582B (zh) * | 2022-04-20 | 2023-10-03 | 南京工业大学 | 一种用于合成纳米颗粒的微流控芯片装置及其应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2013097262A1 (zh) | 2013-07-04 |
CN102527453B (zh) | 2014-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102527453B (zh) | 一种应用于纳米颗粒制备的高并行微流道芯片 | |
CN202538793U (zh) | 一种应用于纳米颗粒制备的高并行微流道芯片 | |
Zhang et al. | A novel approach for precisely controlled multiple cell patterning in microfluidic chips by inkjet printing and the detection of drug metabolism and diffusion | |
KR101307196B1 (ko) | 미세 세포 배양 장치 | |
Dendukuri et al. | The synthesis and assembly of polymeric microparticles using microfluidics | |
CN112275336B (zh) | 一种多通道集成微流控芯片及其高通量制备单分散凝胶微球的方法 | |
US11117132B2 (en) | Biocompatible micropillar array substrate and methods for fabricating such substrate | |
Kang et al. | Mass production of highly monodisperse polymeric nanoparticles by parallel flow focusing system | |
CN106754317B (zh) | 一种微流体细胞药物浓度梯度生成器 | |
Li et al. | In-channel responsive surface wettability for reversible and multiform emulsion droplet preparation and applications | |
Hu et al. | Versatile microfluidic droplets array for bioanalysis | |
Kruss et al. | Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies | |
CA3113690A1 (en) | Three-dimensional bioreactors | |
Manzoor et al. | A review on microwell and microfluidic geometric array fabrication techniques and its potential applications in cellular studies | |
Moghadas et al. | A high-performance polydimethylsiloxane electrospun membrane for cell culture in lab-on-a-chip | |
CN106423315B (zh) | 一种基于微流控芯片的多物质梯度混合液滴形成装置 | |
Sahin et al. | Flow lithography for structured microparticles: fundamentals, methods and applications | |
AU2018340884A1 (en) | Microfluidic assisted fabrication of polymer microparticle-metal nanoparticle composites | |
Paul et al. | A “dry and wet hybrid” lithography technique for multilevel replication templates: Applications to microfluidic neuron culture and two-phase global mixing | |
Lee et al. | Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip | |
KR101442059B1 (ko) | 미세 세포 배양 장치 및 제조 방법 | |
Kronenfeld et al. | Roll-to-roll, high-resolution 3D printing of shape-specific particles | |
Ng et al. | Microfluidic immunodetection of cancer cells via site-specific microcontact printing of antibodies on nanoporous surface | |
Chen et al. | Surface-tension-confined droplet microfluidics☆ | |
Mu et al. | Tumor-on-a-chip devices for cancer immunotherapy |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU INNODICINE MEDICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: BEIJING RSINNO BIOMEDICINE TECHNOLOGY CO., LTD. Effective date: 20130905 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100080 HAIDIAN, BEIJING TO: 510006 GUANGZHOU, GUANGDONG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20130905 Address after: 510006 Guangdong city of Guangzhou province Panyu District Xiaoguwei Street Outer Ring Road No. 280 Building No. 302, a department of Guangdong Pharmaceutical University Applicant after: GUANGZHOU INNODICINE MEDICAL TECHNOLOGY CO., LTD. Address before: 100080, room 6, 801 South Street, Haidian District, Beijing, Zhongguancun Applicant before: Beijing Rsinno Biomedicine Technology Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: BEIJING RSINNO BIOMEDICINE TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: GUANGZHOU INNODICINE MEDICAL TECHNOLOGY CO., LTD. Effective date: 20140415 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 510006 GUANGZHOU, GUANGDONG PROVINCE TO: 100080 HAIDIAN, BEIJING |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140415 Address after: 100080, room 6, 801 South Street, Haidian District, Beijing, Zhongguancun Patentee after: Beijing Rsinno Biomedicine Technology Co.,Ltd. Address before: 510006 Guangdong city of Guangzhou province Panyu District Xiaoguwei Street Outer Ring Road No. 280 Building No. 302, a department of Guangdong Pharmaceutical University Patentee before: GUANGZHOU INNODICINE MEDICAL TECHNOLOGY CO., LTD. |
|
ASS | Succession or assignment of patent right |
Owner name: LI GANGZHEN Free format text: FORMER OWNER: BEIJING RSINNO BIOMEDICINE TECHNOLOGY CO., LTD. Effective date: 20140429 Owner name: TANG MIN Effective date: 20140429 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100080 HAIDIAN, BEIJING TO: 510006 GUANGZHOU, GUANGDONG PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140429 Address after: 510006 Guangdong city of Guangzhou province Panyu District Xiaoguwei Street Outer Ring Road No. 280 Building No. 302, a department of Guangdong Pharmaceutical University Patentee after: Li Gangzhen Patentee after: Tang Min Address before: 100080, room 6, 801 South Street, Haidian District, Beijing, Zhongguancun Patentee before: Beijing Rsinno Biomedicine Technology Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140312 Termination date: 20161230 |
|
CF01 | Termination of patent right due to non-payment of annual fee |