CN102526706B - 牙周病和牙髓疾病的治疗剂以及治疗方法 - Google Patents

牙周病和牙髓疾病的治疗剂以及治疗方法 Download PDF

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Publication number
CN102526706B
CN102526706B CN201210032026.5A CN201210032026A CN102526706B CN 102526706 B CN102526706 B CN 102526706B CN 201210032026 A CN201210032026 A CN 201210032026A CN 102526706 B CN102526706 B CN 102526706B
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China
Prior art keywords
cell
bdnf
mrna expression
ngf
action time
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Expired - Fee Related
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CN201210032026.5A
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English (en)
Chinese (zh)
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CN102526706A (zh
Inventor
栗原英见
河口浩之
武田克浩
柴秀树
水野智仁
吉野宏
长谷川直彦
筱原弘明
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Two Cells Co Ltd
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Two Cells Co Ltd
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201210032026.5A 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法 Expired - Fee Related CN102526706B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003316719 2003-09-09
JP2003-316719 2003-09-09

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2004800311946A Division CN1871024B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法

Publications (2)

Publication Number Publication Date
CN102526706A CN102526706A (zh) 2012-07-04
CN102526706B true CN102526706B (zh) 2014-07-30

Family

ID=34308464

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201210032026.5A Expired - Fee Related CN102526706B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN201210032750.8A Expired - Fee Related CN102600455B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN2004800311946A Expired - Fee Related CN1871024B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201210032750.8A Expired - Fee Related CN102600455B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法
CN2004800311946A Expired - Fee Related CN1871024B (zh) 2003-09-09 2004-09-08 牙周病和牙髓疾病的治疗剂以及治疗方法

Country Status (8)

Country Link
US (3) US8158752B2 (enExample)
EP (3) EP1671641B1 (enExample)
JP (2) JP4589233B2 (enExample)
CN (3) CN102526706B (enExample)
AU (1) AU2004271843B2 (enExample)
RU (1) RU2336089C2 (enExample)
TW (1) TW200513264A (enExample)
WO (1) WO2005025605A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8113837B2 (en) 2007-11-26 2012-02-14 Peter John Zegarelli Oral appliance for delivering a medicament
US8927284B2 (en) * 2009-01-28 2015-01-06 Organ Technologies, Inc. Method for producing tooth
US8470303B2 (en) * 2010-02-02 2013-06-25 James C. Richards Automated method and system for introducing molecular iodine into drinking water
RU2449760C1 (ru) * 2011-01-12 2012-05-10 Светлана Минифаритовна Алетдинова Способ лечения хронических верхушечных периодонтитов
US11273022B2 (en) 2018-02-13 2022-03-15 Emanate Biomedical, Inc. Oral appliance in a blockchain system
US20190247173A1 (en) 2018-02-13 2019-08-15 Peter John Zegarelli Methods of making an oral appliance
WO2019183201A1 (en) * 2018-03-20 2019-09-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Regeneration of vital tooth pulp
US12440604B2 (en) 2018-06-13 2025-10-14 University of Pittsburgh—of the Commonwealth System of Higher Education Bone regeneration in compromised wounds
CN112220966A (zh) * 2020-11-23 2021-01-15 北京大学口腔医学院 一种注射剂、注射剂的制备方法及其在牙髓再生中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5372503A (en) * 1993-04-27 1994-12-13 Dental Marketing Specialists, Inc. Method for installation of a dental implant
CA2187355C (en) * 1994-04-08 2009-10-13 Richard L. Dunn An adjunctive polymer system for use with medical device
AU723740B2 (en) * 1995-06-06 2000-09-07 Howmedica Inc. Biocompatible hydroxyapatite formulations and uses therefor
RU2096031C1 (ru) * 1996-09-19 1997-11-20 Акционерное общество "НИЗАР" Средство для профилактики и лечения воспалительных заболеваний тканей пародонта

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KEIJO LUUKKO et al.Neurotrophin mRNA Expression in the Developing Tooth Suggests Multiple Roles in Innervation and Organogenesis.《DEVELOPMENTAL DYNAMICS》.1997,(第210期),第117-129页.
Neurotrophin mRNA Expression in the Developing Tooth Suggests Multiple Roles in Innervation and Organogenesis;KEIJO LUUKKO et al;《DEVELOPMENTAL DYNAMICS》;19971231(第210期);第117-129页 *

Also Published As

Publication number Publication date
JP4589233B2 (ja) 2010-12-01
US9089606B2 (en) 2015-07-28
EP1671641B1 (en) 2013-11-06
JP5313209B2 (ja) 2013-10-09
EP1671641A1 (en) 2006-06-21
CN1871024B (zh) 2012-03-28
JPWO2005025605A1 (ja) 2007-11-08
CN1871024A (zh) 2006-11-29
US20120214738A1 (en) 2012-08-23
WO2005025605A1 (ja) 2005-03-24
JP2010215661A (ja) 2010-09-30
US8158752B2 (en) 2012-04-17
RU2006111465A (ru) 2007-10-27
EP2460528A1 (en) 2012-06-06
EP2460528B1 (en) 2014-03-19
US20120165255A1 (en) 2012-06-28
EP2460529A1 (en) 2012-06-06
CN102600455A (zh) 2012-07-25
AU2004271843A1 (en) 2005-03-24
RU2336089C2 (ru) 2008-10-20
CN102600455B (zh) 2015-04-15
TW200513264A (en) 2005-04-16
EP1671641A4 (en) 2009-08-19
US8513191B2 (en) 2013-08-20
AU2004271843B2 (en) 2010-04-08
EP2460529B1 (en) 2014-08-20
CN102526706A (zh) 2012-07-04
US20070071693A1 (en) 2007-03-29

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