CN102526521B - Traditional Chinese medicine composition powder for treating nephropathogenic infectious bronchitis in chicken - Google Patents
Traditional Chinese medicine composition powder for treating nephropathogenic infectious bronchitis in chicken Download PDFInfo
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- CN102526521B CN102526521B CN 201210016596 CN201210016596A CN102526521B CN 102526521 B CN102526521 B CN 102526521B CN 201210016596 CN201210016596 CN 201210016596 CN 201210016596 A CN201210016596 A CN 201210016596A CN 102526521 B CN102526521 B CN 102526521B
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Abstract
The invention provides a traditional Chinese medicine composition powder for treating nephropathogenic infectious bronchitis in chicken. The preparation method of the powder comprises the following steps of: a, washing the raw components of the traditional Chinese medicine composition with water, taking out and airing; b, putting baikal skullcap root, honeysuckle, isatis root and gypsum respectively into an earthen pot and baking into charcoal, pulverizing into fine powder respectively by a pulverizer and sieving; delivering dried bamboo shavings, mulberry leaf, white mulberry root-bark, subprostrate soplhor root, bighead atractylodes rhizome and lily respectively into a slicer for slicing into flakes, then delivering into a pulverizer for pulverizing into fine powder and sieving; and c, putting the sieved fine powder obtained in the previous steps into a mixer for fully mixing to obtain a powder, and then subpackaging with small bottles or packing boxes. The traditional Chinese medicine composition for treating chicken suffering from nephropathogenic infectious bronchitis in chicken has the advantages of obvious curative effect, high cure rate, no toxic side effects, low recurrence rate, no chemical injury, no drug resistance, low cost and the like, and also has the effects on treating both principal and secondary aspects of disease, strengthening the body resistance and eliminating the pathogenic factor.
Description
Technical field
The present invention relates to the herbal medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of Nephropathogenic infectious bronchitis.
Background technology
Infectious bronchitis of chicken (infectious bronchitis, IB) be by avian infectious bronchitis virus (infectious bronchitis virus, IBV) cause chicken a kind of acute, the height contagious disease.Main infringement chicken respiratory system, the genito-urinary system digestive system of unifying should disease can cause that weightening finish, the price of deed and the fertility performance of chicken reduced, chicken group mortality rate is increased, and is one of serious infectious diseases of serious harm world aviculture.
Infect the difference that main organs is encroached in the back according to the different virus strain, often be divided into breathing pattern, kidney type, glandular stomach type, gonotype infectious bronchitis.Nephropathogenic infectious bronchitis (Nep hropathogenic infectious bronchitis, NIB) be by having a liking for renal type infectious bronchitis virus (Nep hropat hogenic infectious bronchitis virus, a kind of acute, the high lethal of the chicken that NIBV) causes, respiratory infectious disease contagious.American scholar Winterfield R W equals to find and be separated to the IBV that can cause the Testis et penis Gallus domesticus pathological changes first in the U.S. in 1962.This disease sickness rate can be up to 100%, and mortality rate 10%-50%, morbidity age in days mostly are 3-7 age in week.Winterfield etc. discover that chicken has obvious age resistance to renal type infectious bronchitis, low temperature stress, trophic factor is the major reason that promotes that primary disease takes place.
At present; if prevent the corresponding vaccine of this sick drug main; has certain immanoprotection action after the correct immunity; significantly reduced should disease large tracts of land take place and popular; but in production practices; owing to have immune programme for children imperfection or immunizing dose deficiency or immunization method is improper or leak and to exempt from even wait problems unavoidably, cause this disease to be the locality formula of distributing every year and take place, especially all the more so in prevailing some rural area of the number of animals raised.In addition, the renal type infectious bronchitis virus stain has a plurality of serotypes might reach 16 serotypes, moreover lack between the different shaped strain or the mutual immunity of part only arranged, this shows that single is the generation that can not control this disease fully with vaccine this existing public technology of this disease of preventing epidemic; In case this disease takes place, the medicine of disclosed control Nephropathogenic infectious bronchitis also has Western medicine and Chinese medicine two big classes in the prior art except vaccine.Commercially available Western medicine does not still have the specific treatment medicine, generally adopts symptomatic therapy, though but mitigate the disease, reduce deadly, curative effect is too poor.
Chinese medicine is carrying out comprehensively regulating and is improving aspects such as immunity of organisms, premunition and antiviral to have unique distinction to the animal body physiological function, at present, it is more that Chinese veterinarian treats the bronchitic Chinese medicine preparation of Testis et penis Gallus domesticus type, proves through clinical use, and some medications are imitated slow, the course for the treatment of is long, to the patient that the course of disease is short, the state of an illness is lighter, curative effect still can, longer to the course of disease, the patient that the state of an illness is heavier, its curative effect is just obvious inadequately.
Summary of the invention
Technical problem to be solved by this invention is to be to provide a kind of novel Chinese medicine composition of Nephropathogenic infectious bronchitis and preparation method thereof that is used for the treatment of, treatment has evident in efficacy to Nephropathogenic infectious bronchitis to adopt this Chinese medicine composition, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, the cure rate height has no side effect, be difficult for recurrence, no poisoning has no drug resistance, low cost and other advantages.
Ask that in order to solve above-mentioned technology the invention provides a kind of Chinese medicine composition composition powders, the preparation method of described powder comprises:
A, each raw material components of described Chinese medicine composition is washed with water totally, pull out and dry;
B, Radix Scutellariae, Flos Lonicerae, Radix Isatidis and Gypsum Fibrosum are put into marmite respectively fry into charcoal, respectively it is ground into smalls with pulverizer, sieve; Dried Caulis Bambusae In Taenia, Folium Mori, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii sent into respectively be cut into flakelet in the microtome, send into pulverizer again and be ground into smalls, sieve;
C, the fine powder after the above-mentioned steps gained sieved drop into the abundant mixing of mixing and blending machine, obtain powder, subsequently with bottle or packing box packing.
Wherein, each component in the described Chinese medicine composition and the ratio of weight and number of each component are Radix Scutellariae 35～45 weight portions, Flos Lonicerae 25～35 weight portions, Radix Isatidis 20～30 weight portions, Caulis Bambusae In Taenia 12～16 weight portions, Folium Mori 12～17 weight portions, Gypsum Fibrosum 10～14 weight portions, Cortex Mori 15～20 weight portions, Radix Sophorae Tonkinensis 8～13 weight portions, the Rhizoma Atractylodis Macrocephalae 13～18 weight portions and Bulbus Lilii 13～17 weight portions.
Wherein, the ratio of weight and number of each component in the described Chinese medicine composition is Radix Scutellariae 40～45 weight portions, Flos Lonicerae 30～35 weight portions, Radix Isatidis 25～30 weight portions, Caulis Bambusae In Taenia 14～16 weight portions, Folium Mori 15～17 weight portions, Gypsum Fibrosum 12～14 weight portions, Cortex Mori 17～20 weight portions, Radix Sophorae Tonkinensis 11～13 weight portions, the Rhizoma Atractylodis Macrocephalae 16～18 weight portions, Bulbus Lilii 15～17 weight portions.
Ask that in order to solve above-mentioned technology the invention provides a kind of fodder compound, it comprises: above-mentioned Chinese medicine composition composition powders and feed vector.
Wherein, the ratio of weight and number of described feed vector and described Chinese medicine composition composition powders can be 100 weight portions: 0.5～1.5 weight portion.
Wherein, described fodder compound also comprises following component, Sal, calcium hydrogen phosphate, mineral, vitamin, aminoacid and health-care agent.
Wherein, feed vector with respect to 100 weight portions, described Sal is preferably 0.5～1.5 weight portion, described calcium bicarbonate is preferably 0.5～1 weight portion, described mineral is preferably 0.2～1 weight portion, described Vitamin U is elected 0.5～1.5 weight portion as, and described aminoacid is preferably 1～2 weight portion, and described health-care agent is preferably 0.5～1 weight portion.
Wherein, described health-care agent can be the mixture of Maifanitum, sodium bicarbonate, Fructus Crataegi powder, Montmorillonitum, zeolite powder and bentonite composition.
Ask in order to solve above-mentioned technology, the invention provides the preparation method of above-mentioned fodder compound, it comprises: the first step, with the described Chinese medicine composition of powder preparation formulation, described feed vector and described additive mixing except Chinese medicine composition, putting into blender stirs, put into pulverizer subsequently and be ground into powder, the powder that obtains is put into dehydrator dry;
In second step, treat that material that the first step obtains is down to put into blender again after the room temperature and stir that it is expanded to put into bulking machine subsequently, the material after expanded is put into the grit machine produce the precipitation hard pellet diet, sieves, and obtains described fodder compound.
Wherein, in the described first step, in blender mixing time be preferably 120 minutes～150 minutes, the aridity of material in dehydrator after the oven dry is 70%～80%, the time of smoking is 40～60 minutes.
In described second step, in blender mixing time be preferably 150 minutes～180 minutes, the aridity of the material after expanded in bulking machine is 85%～95%, and the expanded time is 1 hour～2 hours, and the order number of the fodder compound that the back of sieving obtains is 50 orders～100 orders.
Beneficial effect of the present invention:
With respect to the medicine that is used for the treatment of Nephropathogenic infectious bronchitis of the prior art, adopt this Chinese medicine composition to have evident in efficacy to the treatment of the chicken that suffers from Nephropathogenic infectious bronchitis, treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation, Yin Yang balancing, the cure rate height has no side effect, and is difficult for recurrence, no poisoning, low cost and other advantages.
The specific embodiment
The clinical symptoms of Nephropathogenic infectious bronchitis is: show slight respiratory symptom, distinctive symptom is that the disease chicken is drawn white loose stool, and the perianal feather is often stained by white Excreta.It is hyperuricemia that the pathology of feature change, and cuts open the visible kidney enlargement of inspection, ureter is full of white urate crystal.
The pathological observation of Nephropathogenic infectious bronchitis is: tracheal epithelial cell swelling, come off, the lamina propria connective tissue thickens, and a large amount of inflammatory cell infiltrations is arranged, and the trachea intracavity contains epithelial cell mucus secretion and the blood that comes off.The epithelial cell swelling of lungs tertiary bronchus, and in various degree degeneration and necrosis are arranged.The expansion of tertiary bronchus tube chamber contains the blood of volume and the epithelial cell that necrosis comes off.The expansion of lung room, the epithelial cell that epithelial cell swelling, degeneration, tube chamber contain erythrocyte, inflammatory leukocytes and come off.Breathe the swelling of capillary tube epithelial cell, degeneration, come off, breathe intercapillary connective tissue proliferation, and massive inflammatory cells infiltrated is arranged, form " solid ", lost original structure.The blood capillary of whole lungs, small artery, venule hyperemia, the stagnation of the blood.The endocardial endotheliocytic swelling of heart, what have comes off in the chambers of the heart.The cardiac muscle fiber enlargement, unclear transverse striation of muscle fiber is to disappearing the karyopyknosis that has or dissolving, interstitial edema, capillary injection, the stagnation of the blood.The liver swelling of liver cell, Cytoplasm is light to be dyed, and cell presents granular degeneration, blister degeneration, and nucleus is unclear, and serious karyopycnosis or dissolving are so that downright bad.The hepatic sinusoid expansion contains a large amount of erythrocyte, lymphocyte and Kupffer.Small artery, venular endothelium swelling in the liver have a large amount of blood to fill circumvascular connective tissue proliferation in the tube chamber.And contain the inflammatory leukocytes of volume.The swelling of interlobular bile duct endothelium, degeneration, come off in tube chamber.The stagnation of the blood, hemorrhage in the swelling of renal glomerulus capillary endothelium, tube chamber, and inflammatory cell infiltration is arranged.The renal capsule expansion.Renal cells swelling at different levels, granular degeneration, karyopyknosis or dissolving, necrosis are full of erythrocyte, inflammatory leukocytes, epithelial cell and the albumen that oozes out and urate crystal that necrosis comes off in the tube chamber, and serious renal tubules original structure is unclear.Kidney interstitial edema, hypertrophy, a large amount of inflammatory cell infiltrations is arranged.The swelling of spleen white pulp loses original structure, and lymphocyte separates, and has the volume erythrocyte to soak into.The splenic cords expansion, cell is loose, and a large amount of inflammatory cell infiltrations is arranged.Snius lienis is expanded, and erythrocyte, lymphocyte, the macrophage of volume arranged in the hole.The swelling of intestinal tube mucous epithelium, come off, intrinsic rete connective tissue proliferation, and inflammatory cell infiltration is arranged.Fluff structures is imperfect.The epithelial cell that enteric cavity contains blood and comes off.
Traditional Chinese veterinary medicine thinks that the pathogeny of Nephropathogenic infectious bronchitis is: because the epidemic disease pathogen is violated kidney, the infringement kidney makes the renal function imbalance, water liquid can not be failed cloth to reach extremity, and then chicken is skinny and wizened, cuts open inspection, renomegaly, excess of the kidney matter is pale, and the piebaldism kidney has a large amount of urate deposition in the ureter.Continuous then invade taste can not transmitting and distributing the fluids, the functional disorder of becoming thoroughly decomposed, lack of appetite, spirit is depressed, white watery stools is then drawn in necking down, and is skinny and wizened.Invade lungs, inhibited pulmonary QI falls, can not regulating fluid apssage under defeated bladder, then restraint capsule hydrops, expectorant is arranged, then dyspnea, rale, according to the Chinese medical discrimination theory, treatment should be principle with heat-clearing and toxic substances removing, dispersing and lowering lung-QI, preventing phlegm from forming and stopping coughing and raising immunity of organisms.
Based on above-mentioned theory, the invention provides a kind of like this Chinese medicine composition composition formula that is used for the treatment of Nephropathogenic infectious bronchitis, it comprises: Radix Scutellariae, Flos Lonicerae, Radix Isatidis, Caulis Bambusae In Taenia, Folium Mori, Gypsum Fibrosum, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii.
Radix Scutellariae: bitter in the mouth, cold in nature, go into the heart, lung, stomach, gallbladder, large intestine channel, heat clearing and damp drying is arranged, eliminating fire and detoxication, antiabortive, the effect of hemostasis is mainly used in diarrhoea, dysentery, jaundice, pyretic stranguria due to damp and hot; The cough due to lung-heat, thirsty pharyngalgia also can be used for excessive fetal movement due to heat in pregnancy, and the pyretic toxicity pathogenic fire is invaded the swollen card of carbuncle sore poison of excessive skin.That Radix Scutellariae has is analgesic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppress effect such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, bacillus pyocyaneus are had certain inhibitory action, upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. are had curative effect preferably.
Radix Isatidis: bitter in the mouth, cold in nature, go into the heart, liver, gallbladder, stomach warp, the effect of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving is arranged, be used for the treatment of maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat cards such as epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis, Radix Isatidis has inhibitory action to various bacteria. and infusion has in various degree inhibitory action to bacillus subtilis, staphylococcus aureus, sarcine, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery (will is congratulated, Fu Shi) bacillus, bacillus enteritidis etc.; The acetone leachate also has similar effect, and effective to Hemolytic streptococcus, similar to bacteriostasis and Bulbus Allii, the Flos Lonicerae of A type meningococcus. influenza virus PR8 strain and Jing Ke 68-1 strain there are obvious inhibitory action. in vitro Radix Isatidis is killed leptospiral effect.
Flos Lonicerae: have another name called Flos Lonicerae, Flos Lonicerae, Flos Lonicerae, two precious flowers, sweet in the mouth, cold in nature is gone into the heart, lung, stomach, large intestine channel, the effect of heat-clearing and toxic substances removing is arranged, holding concurrently can eliminating pathogenic heat from blood to cure dysentery, is mainly used in affection due to external wind and heat, the epidemic febrile disease pyretic toxicity is contained, or epidemic febrile disease is from the beginning of pathogenic heat still at the part of the body cavity above the diaphragm housing the heart and lungs and when not descending; Pyretic toxicity dysentery, stool hematochezia; The fever disease in summer card; The carbuncle sore that pyretic toxicity gathers is from the beginning of the ， inflammation heat person of swelling and ache, and other skin infections, and this thing has antipyretic effect preferably, and antiinflammatory action is arranged, and can promote leukocytic phagocytic function, and multiple pyococcus and pathogenic entero becteria are had stronger bacteriostasis.
The Radix Isatidis bitter cold, purging fire and cooling blood, kind clearing heat in YING system toxic heat in blood share with Flos Lonicerae, complements each other, and the effect of removing summer-heat pyretic toxicity strengthens, and is mainly used in treating the swollen heating of skin infection poison.
Caulis Bambusae In Taenia: sweet in the mouth, cold nature is gone into lung, stomach warp, the effect that removing heat-phlegm is arranged, relieves restlessness and prevents vomiting, being mainly used in lung meridian has heat, the cough ant phlegm of expectorant and accumulation of heat; The gallbladder fire is held expectorant under the arm, violates lung and disturbs the vexed of the heart, the palpitation with fear insomnia; Middle wind-phlegm fan, insufficiency of stomach is held the cards such as vomiting of heat under the arm.
It is not peaceful that Radix Scutellariae and Caulis Bambusae In Taenia two medicines share the unhappiness that can treat heat-phlegm pent-up, and gastropyretic vomiting.
Folium Mori: sweet in the mouth, hardship; Cold in nature.Return lung, Liver Channel has dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, and suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis is used for anemopyretic cold and conjunctival congestion and swelling pain, wind-fire order disease, dryness-heat impairing the lung, the few expectorant of dry cough, " Bencao Jingshu ": " herbal classic " odorlessness.Detailed its cures mainly, and should be that sweet in the mouth gas is cold nontoxic.So sweet beneficial blood, so cold removing heat from blood, so sweet cold being harmonious is the therapeutic method to keep the adverse QI flowing downwards and tonifying YIN.Be with the main deficiency of YIN cold and heat of energy, and because of the interior-heat perspiration.Its property is held concurrently dry, so can remove beriberi edema, sharp intestine and small intestine again.The golden gas of former official report is so can remove wind again.Through frost the respectful clearly of the world that then get both, quench the thirst so can make eye bright again.Send out the person, after the blood, so beneficial blood is again can long hair, and so removing heat from blood is emesis blood again.Close the carbuncle mouth, net for catching birds or fish is worn the palm, treats the soup fire, and all refrigerant merit of enriching blood also.
Gypsum Fibrosum: acrid in the mouth, sweet, property Great Cold, go into lung, the stomach warp, clearing away heat-fire is arranged, the quench the thirst effect of relieving restlessness, its abnormal smells from the patient is all thin and matter heavy, the excess-heat of energy removing summer-heat stomach of foot Yang Ming, filling the air for the treatment of pathogen invading YANG MING is high hot, profuse sweating, thirsty, vexed, symptoms such as arteries and veins flood, key medicine for the bright stomach warp of sun, to epidemic encephalitis, encephalitis b, high heat due to the pneumonia etc. has antipyretic effect preferably, and have relieving convulsion effect concurrently, also can be used for the burning pain in the epigastrium due to the high Sheng of stomach-fire, headache, aphtha of the mouth and tongue and heat-damp in summer dysphoria with smothery sensation, the lung-heat cough with asthma, restlessness and thirst, damp and hot obstruction of meridian, symptoms such as the pyretic arthralgia of arthralgia.
Folium Mori are sweet cold and moisten, the excess-fire of the kind eliminating the pathogens from the lung stomach of Gypsum Fibrosum, and the two share, refrigerant moistening, pathogenic fire purging and impairment of body fluid not, treatment dryness-heat impairing the lung is to cards such as dry cough without phlegm.
Cortex Mori: sweet in the mouth, cold in nature, go into lung meridian, have eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema is one of common drug of eliminating the pathogens from the lung row water, be mainly used in the dyspnea with rapid respiration and cough that the strongly fragrant lung of pathogenic heat, QI rising in reverse order do not fall, excessive phlegm, yellow skin, stop in the phlegm retention, the distension cough with dyspnea that the breast sun is not declared, Lung Qi obstraction, steam do not walk to the edema dyspnea with fullness of the chest; dysuria; function of gallbladder promoting, promote the production of body fluid cards such as eliminating stagnation.
Radix Sophorae Tonkinensis: bitter in the mouth, cold in nature, have and relieve inflammation or internal heat, detoxifcation, detumescence, the effect of pain relieving cures mainly: control retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, the dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis." Bencao Jingshu ": " Radix Sophorae Tonkinensis, so sweet and malicious, so cold heat extraction, all malicious Bi Rebixin get poor gas, the flavor of sweetness and bitterness, then all poison are explained by oneself, so be medicine on the detoxifcation heat clearing away.All pains must be because of in heat, and malicious analgesic diffusing, then pain is from ending, and skin ulcer swells and disappears certainly.Acute jaundice is that the heat in blood utmost point is sent out, so must generate heat, smokes on the steam and then sends out cough.Parasites is also damp and hot the change, thus know the master, and obtain special effect also more.", " in the newborn poison of going into to loose, breast carcinoma can disappear.”
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, go into spleen, stomach warp, the spleen reinforcing promoting the circulation of QI is arranged, the dampness diuretic, strengthening superficial resistance to stop perspiration, the effect that activating the spleen is moisturized is mainly used in the feeling of fullness diarrhoea due to dysfunction of the spleen in transportation, the QI failing to transform into body fluid, the phlegm retention edema; The vexed lazy speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; Cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, and gastrointestinal function is had regulating action.
Bulbus Lilii: sweet in the mouth, cold nature.Go into the heart, lung meridian, be used for nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization, be used for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded has nourishing YIN and moistening the lung cough-relieving effect, be used for the cough caused by dryness-heat of deficiency of lung-YIN, sputum mixed with blood is controlled chronic cough of deficiency lung, the chronic cough spitting of blood has the clearing away heart-fire for tranquillization effect, and it is unclear to be used for the calentura waste heat, the fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep etc.
Further preferred, the described Chinese medicine composition that is used for the treatment of Nephropathogenic infectious bronchitis only is made of said components.
In the described Chinese medicine composition that is used for the treatment of Nephropathogenic infectious bronchitis, the ratio of weight and number of various components can be preferably: Radix Scutellariae 35～45 weight portions, Flos Lonicerae 25～35 weight portions, Radix Isatidis 20～30 weight portions, Caulis Bambusae In Taenia 12～16 weight portions, Folium Mori 12～17 weight portions, Gypsum Fibrosum 10～14 weight portions, Cortex Mori 15～20 weight portions, Radix Sophorae Tonkinensis 8～13 weight portions, the Rhizoma Atractylodis Macrocephalae 13～18 weight portions, Bulbus Lilii 13～17 weight portions.
In the described Chinese medicine composition that is used for the treatment of the animal Nephropathogenic infectious bronchitis, the ratio of weight and number of various components also can be more preferably: Radix Scutellariae 40～45 weight portions, Flos Lonicerae 30～35 weight portions, Radix Isatidis 25～30 weight portions, Caulis Bambusae In Taenia 14～16 weight portions, Folium Mori 15～17 weight portions, Gypsum Fibrosum 12～14 weight portions, Cortex Mori 17～20 weight portions, Radix Sophorae Tonkinensis 11～13 weight portions, the Rhizoma Atractylodis Macrocephalae 16～18 weight portions, Bulbus Lilii 15～17 weight portions.
For promoting ill chicken to eliminate eating accumulation, facilitating digestion absorbs, and can also comprise Fructus Crataegi and Massa Medicata Fermentata in the described Chinese medicine composition that is used for the treatment of Nephropathogenic infectious bronchitis.
Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature is gone into spleen, stomach, Liver Channel, is used for promoting digestion and invigorating the stomach, and the circulation of qi promoting dissipating blood stasis is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, has loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc. had the obvious suppression effect.
Massa Medicata Fermentata sweet in the mouth, suffering, warm in nature, go into spleen, the stomach warp has digestion-promoting spleen-invigorating, reduces phlegm, effect such as blood-activating analgetic.Be mainly used in dyspepsia and do not change, distension and fullness in the abdomen, symptoms such as lack of appetite diarrhoea, the phlegm syndrome due to mistake is good for to spleen fortune, and blood stasis pain has certain curative effect.
By adding these two kinds of auxiliary elements of Fructus Crataegi and Massa Medicata Fermentata, can eliminate eating accumulation and advance digestion, increase enterogastric peristalsis, in case distension and fullness in the abdomen, lack of appetite, dysentery, have and regulate the flow of vital energy, stomach function regulating, the effect of spleen invigorating makes ill chicken food desire to heighten, improve resistance against diseases and immunologic function, reduce disease incidence rate, play a role in health care, thus the treatment Nephropathogenic infectious bronchitis.
Further preferred, the described Chinese medicine composition that is used for the treatment of Nephropathogenic infectious bronchitis only is made of said components.
Described Fructus Crataegi and the Massa Medicata Fermentata ratio of weight and number in described Chinese medicine composition is Fructus Crataegi 3～6 weight portions, Massa Medicata Fermentata 2～4 weight portions.
Described Chinese medicine composition pharmaceutical dosage form can be decoct or powder.
The administering mode of described Chinese medicine composition is oral.
The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of Nephropathogenic infectious bronchitis, and when the dosage form of described Chinese medicine composition was decoct, its preparation method comprised:
1, described component is mixed in proportion, is ground into powder;
2, will the 1st the step obtain powder and add in the cold water and soaked 12 hours～18 hours, with slow fire boiling, decocting time is 1 hour～2 hours, and decoction liquor is filtered, and obtains first filtrate, the quality of the water that adds is 4～6 times of the powder quality that obtained in the 1st step;
3, the filtering residue that the 2nd step filter was obtained adds in the cold water again, with slow fire boiling 2 hours～3 hours, filters and obtains second filtrate, identical in the quality of the water that adds and the 2nd step;
4, merge twice filtrate, concentrating under reduced pressure is removed part water, obtains described decoct.
The crude drug concentration of described decoct aqueous solution is preferably 1.5g/ml～3g/ml.
Described Chinese medicine composition in use, if take with decoct, 4～6 doses of every days, per 7 days is a course for the treatment of.
The present invention also provides the above-mentioned preparation method that is used for the treatment of the Chinese medicine composition of Nephropathogenic infectious bronchitis, and when the dosage form of described Chinese medicine composition was powder, its preparation method comprised:
A, described raw material is washed with water totally, pull out and dry;
B, Radix Scutellariae, Flos Lonicerae, Radix Isatidis and Gypsum Fibrosum are put into marmite respectively fry into charcoal, respectively it is ground into smalls with pulverizer, sieve; Dried Caulis Bambusae In Taenia, Folium Mori, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii sent into respectively be cut into flakelet in the microtome, send into pulverizer again and be ground into smalls, sieve;
C, the fine powder after the above-mentioned steps gained sieved drop into the abundant mixing of mixing and blending machine, obtain powder, subsequently with bottle or packing box packing.
In the described b step, the used sieve that sieves can be 100～200 orders, and the time of pulverizing in pulverizer can be 18～20 minutes.
In the described c step, mixing time can be 30～50 minutes.
Described Chinese medicine composition in use, if take with powder, 4～6 doses of every days, per 7 days is a course for the treatment of, in the use, described powder is dissolved in the water, irritates the ill chicken of stomach, the crude drug concentration of described powder aqueous solution is preferably 1.5g/ml～3g/ml.
The present invention also provides the another kind of using method of above-mentioned Chinese medicine composition, and it comprises: described Chinese medicine composition composition powders is mixed stirring mutually with feed vector, subsequently with the ill chicken of this stirred mixture feeding.
The present invention also provides a kind of fodder compound, comprises above-mentioned Chinese medicine composition additive and feed vector in the said composition.
Described feed vector is preferably one or more in grass meal, Testa Tritici, soybean cake, the Semen Maydis powder etc.
The ratio of weight and number of described feed vector and described Chinese medicine composition additive can be 100 weight portions: 0.5～1.5 weight portion, more preferably 100 weight portions: 1～1.5 weight portion.
Can also comprise Sal, calcium hydrogen phosphate, mineral, vitamin, aminoacid and health-care agent in the described fodder compound.
Wherein, mineral can be one or more mixing in copper sulphate pentahydrate, ferrous sulfate monohydrate, manganese sulfate monohydrate, the zinc sulfate monohydrate, and vitamin can be vitamin A, vitamin D
3, one or more mixing in the vitamin E; Aminoacid is one or more mixing in methionine, lysine, threonine, the tryptophan, and health-care agent can be the additive of mixture conduct except Chinese medicine composition that Maifanitum, sodium bicarbonate, Fructus Crataegi powder, Montmorillonitum, zeolite powder and bentonite are formed.
Feed vector with respect to 100 weight portions, the ratio of weight and number of each other additive component is in the described fodder compound: described Sal is preferably 0.5～1.5 weight portion, described calcium bicarbonate is preferably 0.5～1 weight portion, described mineral is preferably 0.2～1 weight portion, described Vitamin U is elected 0.5～1.5 weight portion as, described aminoacid is preferably 1～2 weight portion, and described health-care agent is preferably 0.5～1 weight portion.
The present invention also provides the preparation method of above-mentioned fodder compound, and it comprises:
The first step with the described Chinese medicine composition of powder preparation formulation, above-mentioned feed vector and above-mentioned additive mixing except Chinese medicine composition, is put into blender and is stirred, and puts into pulverizer subsequently and is ground into powder, the powder that obtains is put into dehydrator dry;
In second step, treat that material that the first step obtains is down to put into blender again after the room temperature and stir that it is expanded to put into bulking machine subsequently, the material after expanded is put into the grit machine produce the precipitation hard pellet diet, sieves, and obtains described fodder compound.
In the described first step, in blender mixing time be preferably 120 minutes～150 minutes, the aridity of material in dehydrator after the oven dry is 70%～80%, the time of smoking is 40～60 minutes.
In described second step, in blender mixing time be preferably 150 minutes～180 minutes, the aridity of the material after expanded in bulking machine is 85%～95%, and the expanded time is 1 hour～2 hours, and the order number of the fodder compound that the back of sieving obtains is 50 orders～100 orders.
Below adopt embodiment to describe embodiments of the present invention in detail, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can fully understand and implements according to this.
The toxicity test of embodiment 1 Chinese medicine composition of the present invention
1, acute toxicity test
Median lethal dose(LD 50) (LD to the mouse stomach administration
50) carried out test determination, but do not measure LD
50, therefore carried out mtd test.Result: with Cmax (60%), maximum dosage-feeding (divide in the 120ml/kg one day and give for four times) 100g/Kg irritates stomach, be equivalent to crude drug amount 60g/kg, none death of mice in seven days, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group and control group mice do not have any difference.
2, long term toxicity test
Application Wistar rat will be tested medicine and will be set at high, medium and low three dosage, be respectively 16g/kg, 8g/kg, 4g/kg; Other establishes a matched group, and gastric infusion 90 days, 180 days and the drug withdrawal of part animal were observed the influence to the every physiology of rat, biochemical indicator after 10 days continuously.Experimental result shows: gave the rat continuous oral 180 days with various dose, food-intake and the body weight gain of rat all do not had influence.Hepatic and renal function is not all found the overt toxicity effect.Routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc. be there is no obvious influence, compare no significant difference with matched group between each group.
The decoct preparation of embodiment 2 Chinese medicine compositions
45g Radix Scutellariae, 35g Flos Lonicerae, 30g Radix Isatidis, 16g Caulis Bambusae In Taenia, 17g Folium Mori, 14g Gypsum Fibrosum, 20g Cortex Mori, 13g Radix Sophorae Tonkinensis, the 18g Rhizoma Atractylodis Macrocephalae, 17g Bulbus Lilii are mixed, be ground into powder; To soak 12 hours in the powder adding 1100g cold water that obtain, with slow fire boiling, decocting time is 2 hours, and decoction liquor is filtered, and obtains first filtrate; Add again in the 1100g cold water filtering the filtering residue that obtains, with slow fire boiling 2 hours, filter and obtain second filtrate; Merge filtrate twice, concentrating under reduced pressure is removed part water, obtains described decoct, and the crude drug amount is 2g/ml.
The preparation of embodiment 3 Chinese medicine composition composition powders 1
40g Radix Scutellariae, 30g Flos Lonicerae, 25g Radix Isatidis, 12g Gypsum Fibrosum, 14g Caulis Bambusae In Taenia, 15g Folium Mori, 17g Cortex Mori, 11g Radix Sophorae Tonkinensis, the 16g Rhizoma Atractylodis Macrocephalae and 15g Bulbus Lilii are washed with water respectively totally, pull out and dry; Radix Scutellariae, Flos Lonicerae, Radix Isatidis and Gypsum Fibrosum are put into marmite respectively fry into charcoal, respectively it is ground into smalls with pulverizer, be screened into 100 purpose powder; Dried Caulis Bambusae In Taenia, Folium Mori, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii sent into respectively be cut into flakelet in the microtome, send into pulverizer again and be ground into smalls, be screened into 100 purpose powder; Powder after sieving drops into the abundant mixing of mixing and blending machine and stirred 40 minutes, obtains powder 1, subsequently with bottle or packing box packing.
The preparation of embodiment 4 Chinese medicine composition composition powders 2
45g Radix Scutellariae, 35g Flos Lonicerae, 30g Radix Isatidis, 16g Caulis Bambusae In Taenia, 17g Folium Mori, 14g Gypsum Fibrosum, 20g Cortex Mori, 13g Radix Sophorae Tonkinensis, the 18g Rhizoma Atractylodis Macrocephalae and 17g Bulbus Lilii are washed with water respectively totally, pull out and dry; Radix Scutellariae, Flos Lonicerae, Radix Isatidis and Gypsum Fibrosum are put into marmite respectively fry into charcoal, respectively it is ground into smalls with pulverizer, be screened into 100 purpose powder; Dried Caulis Bambusae In Taenia, Folium Mori, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii sent into respectively be cut into flakelet in the microtome, send into pulverizer again and be ground into smalls, be screened into 100 purpose powder; Powder after sieving drops into the abundant mixing of mixing and blending machine and stirred 40 minutes, obtains powder 2, subsequently with bottle or packing box packing.
The preparation of embodiment 5 fodder compounds 1
Chinese medicine composition composition powders 1,10kg Semen Maydis powder, 150g Sal, 100g calcium bicarbonate, 100g zinc sulfate monohydrate, 150g vitamin E, 200g threonine, 100g Montmorillonitum that 200g embodiment 3 is obtained mix, putting into blender stirred 120 minutes, put into pulverizer subsequently and be ground into powder, the powder that obtains is put into dehydrator smoked 40 minutes, the aridity of the material after the oven dry is 70%; Material to be obtained is put into blender stirring 150 minutes after being down to room temperature again; put into bulking machine subsequently expanded 2 hours; the aridity of the material after expanded is 95%; material after expanded is put into the grit machine produce the precipitation hard pellet diet; sieve; obtain described fodder compound, the order number is 70 orders.
The preparation of embodiment 6 fodder compounds 2
Chinese medicine composition composition powders 2,10kg Semen Maydis powder, 50g Sal, 50g calcium bicarbonate, 20g ferrous sulfate monohydrate, 50g vitamin A, 100g threonine, 50g zeolite powder that 200g embodiment 4 is obtained mix, putting into blender stirred 120 minutes, put into pulverizer subsequently and be ground into powder, the powder that obtains is put into dehydrator smoked 40 minutes, the aridity of the material after the oven dry is 70%; Material to be obtained is put into blender stirring 150 minutes after being down to room temperature again; put into bulking machine subsequently expanded 2 hours; the aridity of the material after expanded is 95%; material after expanded is put into the grit machine produce the precipitation hard pellet diet; sieve; obtain described fodder compound, the order number is 100 orders.
Clinical experiment
1.1 material
1.1.1 for the examination animal
The morbidity chicken is the laying hen of 140 ages in days, is provided by Xingtai City chicken farm, Hebei province.
1.1.2 trial drug
Fodder compound 2 shown in the embodiment 6.
1.2 method
1.2.1 epidemiology
By incidence from the chicken group to the chicken house technical staff, raising situation and the vaccination situation etc. of understanding primary disease is carried out EPDML investigation.
1.2.2 egg inoculation
Take disease chicken kidney and spleen, grind centrifugal 10 min of 2 000 r/min through rubbing, get supernatant and be inoculated in 10 Embryo Gallus domesticus, other 10 egg inoculation normal saline are organized in contrast, and 20 Embryo Gallus domesticus are continued hatching 7d in 37 ℃ of calorstats, and regularly according to egg.
1.2.3 indirect hemagglutination test
Drip the dull and stereotyped coagulation antigen of an IBV at microscope slide, drip a Chicken Wings blood again, fully stir with toothpick, paint the liquid level of 115cm～2cm, shake Sptting plate after leaving standstill slightly gently, see the result behind the 2min.
Criterion: big coagulation sheet or little shot-like particle occur, liquid is transparent fully, and namely 100% coagulation is judged to the positive, the note work++++; Obvious coagulation sheet and granule are arranged, and liquid is almost completely transparent, and namely 75% coagulation is judged to the positive, the note work+++; Visible coagulation sheet and granule are arranged, and liquid is very not transparent, and namely 50% coagulation is judged to the positive ,++; Only can see granule, the liquid muddiness, i.e. 25% coagulation is judged to suspiciously, and note does+; Liquid is evenly muddy, and no agglutination phenomenon is judged to feminine gender, the note work-.
1.2.4 agar gel diffusion test
The preparation of serum to be checked: under aseptic condition, from about the wing venous blood collection 2mL of sick chicken, leave standstill blood sample.After treating blood coagulation, separation of serum.The preparation of agar plate: get agar powder and normal saline dissolves in proportion, boil to color clear and bright.After cooling, pour in the good culture dish of sterilization, the about 2mm of thickness, leave standstill cool off standby.
Punch 1 in central authorities, 6, aperture 3mm, pitch-row 4mm after solidifying on every side.Upper aperture is the 1st hole, is called 2,3,4,5 and 6 holes in the direction of the clock, and medium pore is 7 holes.Standard antigen is placed in the medium pore of agar plate, standard serum is added 1,4 holes, compare, other holes add serum to be checked.Observed result behind 37 ℃ of incubation 12h～24h.When precipitation line occurring between antigen hole and the positive serum hole, precipitation line also appears between serum to be checked hole and the antigen hole, be judged to the positive, the person is judged to feminine gender precipitation line not to the occur.
1.2.5 treatment
100 sick chickens are divided into 2 groups at random, 50 every group.1 group is adopted fodder compound 2 feedings; 2 groups take drugless medication, in contrast group; Other establishes the 3rd group is normal group, does not namely have ill chicken, as the laying rate matched group.The experiment grouping sees Table 1.
Table 1
| Group | Chicken number (only) | Medication |
| 1 | 50 | The normal feeding of 10kg fodder compound 2+10kg water |
| 2 | 50 | The 10kg normal diet compositions+normal feeding of 10kg water |
| 3 | 50 | The 10kg normal diet compositions+normal feeding of 10kg water |
1.3 result and analysis
1.3.1 Epidemiological study
1500 laying hens are raised in the Xingtai City chicken farm, on May 17th, 2010 sudden onset, death appears in morbidity chicken successively, shows as dyspnea dead 6～7 of every day, egg product matter descends.This family is new raiser, and the experience of not raising laying hen lacks the technological guidance of science to the feeding and management of laying hen, and the breed level is lower, and vaccination is untimely, and humidity is low in the hen house, dust is big, raises too intensive, improper ventilation, feces is cleared up untimely.Ammonia odor is heavier in the house, and it is not thorough to sterilize.In addition because the sudden change of weather and do not take to be incubated timely measure has also promoted the generation of primary disease.
1.3.2 clinical symptoms
Sick chicken shows as dyspnea, trachea rale, cough, sneeze and rhinorrhea, draws white light stool, and the drink desire increases, and egg production descends, and produces soft shell, deformity and thick shell egg, and Ovum Gallus domesticus album is thin in water.
1.3.3 cuing open inspection changes
10 sick chickens of death are cutd open inspection, and finding has a large amount of mucus and caseous exudate in trachea, nasal meatus and the nasal sinuses of disease chicken, nasal membrane hyperemia, and air bag presents muddiness, visible a large amount of caseous substance in the trachea of dead chicken.Fallopian tube attenuates, shortens or becomes cryptomere, the follicle distortion, even break.
1.3.4 egg inoculation result
Inoculated into chick embryo is hatched to 7d, and the Embryo Gallus domesticus of inoculation pathological material of disease supernatant all has typical Nephropathogenic infectious bronchitis pathological change, and Embryo Gallus domesticus is crispaturaed, and is stiff, and ossifing in the idiosome surface, has cellulose to adhere to, and Embryo Gallus domesticus is crispaturaed to 1/3 of normal chick embryo.And the chick embryo development of inoculation normal saline is normal.
1.3.5 indirect hemagglutination test result
Dripping the glass plate dropping serum to be checked that antigen is arranged, to observe behind the 2min, obvious agglutinating particle appears, is positive.
1.3.6 agar gel diffusion test result
Form tangible precipitation line between standard serum and the antigen, also form fine and close precipitation line between serum to be checked and the antigen, the result is positive.Through Epidemiological study, clinical symptoms, cut open inspection symptom, egg inoculation, indirect hemagglutination experiment and agar diffusion experiment and make a definite diagnosis the infectious bronchitis that primary disease is the Testis et penis Gallus domesticus type.
1.3.7 treatment
Select for use the fodder compound 2 of embodiment 6 to treat, symptom significantly takes a turn for the better behind 1 group of sick chicken group medication 7d, does not have newly-increased case, and eggshell quality takes a turn for the better behind the 10d, and egg production begins to grow steadily behind the 13d, and the mental status is good, and is vivaciously active.2 groups of sick chicken symptoms do not see and alleviate that mortality rate rises, and the results are shown in Table 2.
Table 2
| Grouping | Chicken number (only) | Dead (only) | Mortality rate (%) | Survival rate (%) | Laying rate (%) |
| 1 | 50 | 1 | 2 | 98 | 89 |
| 2 | 50 | 14 | 28 | 72 | 53 |
| 3 | 50 | 0 | 0 | 100 | 85 |
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not break away to any simple modification, equivalent variations and remodeling that above embodiment does, still belongs to the protection domain of technical solution of the present invention according to technical spirit of the present invention.
Claims (9)
1. Chinese medicine composition composition powders that is used for the treatment of Nephropathogenic infectious bronchitis, it is characterized in that described Chinese medicine composition composition powders only is made of Radix Scutellariae, Flos Lonicerae, Radix Isatidis, Caulis Bambusae In Taenia, Folium Mori, Gypsum Fibrosum, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii component;
The parts by weight of each component are in the described Chinese medicine composition composition powders, Radix Scutellariae 35～45 weight portions, Flos Lonicerae 25～35 weight portions, Radix Isatidis 20～30 weight portions, Caulis Bambusae In Taenia 12～16 weight portions, Folium Mori 12～17 weight portions, Gypsum Fibrosum 10～14 weight portions, Cortex Mori 15～20 weight portions, Radix Sophorae Tonkinensis 8～13 weight portions, the Rhizoma Atractylodis Macrocephalae 13～18 weight portions and Bulbus Lilii 13～17 weight portions;
The preparation method of described powder comprises:
A, each raw material components of Chinese medicine composition is washed with water totally, pull out and dry;
B, Radix Scutellariae, Flos Lonicerae, Radix Isatidis and Gypsum Fibrosum are put into marmite respectively fry into charcoal, respectively it is ground into smalls with pulverizer, sieve; Dried Caulis Bambusae In Taenia, Folium Mori, Cortex Mori, Radix Sophorae Tonkinensis, the Rhizoma Atractylodis Macrocephalae and Bulbus Lilii sent into respectively be cut into flakelet in the microtome, send into pulverizer again and be ground into smalls, sieve;
C, the fine powder after the above-mentioned steps gained sieved drop into the abundant mixing of mixing and blending machine, obtain powder, subsequently with bottle or packing box packing.
2. Chinese medicine composition composition powders as claimed in claim 1, it is characterized in that: the parts by weight of each component in the described Chinese medicine composition composition powders are Radix Scutellariae 40～45 weight portions, Flos Lonicerae 30～35 weight portions, Radix Isatidis 25～30 weight portions, Caulis Bambusae In Taenia 14～16 weight portions, Folium Mori 15～17 weight portions, Gypsum Fibrosum 12～14 weight portions, Cortex Mori 17～20 weight portions, Radix Sophorae Tonkinensis 11～13 weight portions, the Rhizoma Atractylodis Macrocephalae 16～18 weight portions, Bulbus Lilii 15～17 weight portions.
3. a fodder compound is characterized in that, comprising: claim 1 or 2 described Chinese medicine composition composition powders and feed vectors.
4. fodder compound as claimed in claim 3, it is characterized in that: the ratio of weight and number of described feed vector and described Chinese medicine composition composition powders can be 100 weight portions: 0.5～1.5 weight portion.
5. fodder compound as claimed in claim 4, it is characterized in that: described fodder compound also comprises following component, Sal, calcium hydrogen phosphate, mineral, vitamin, aminoacid and health-care agent.
6. fodder compound as claimed in claim 5, it is characterized in that, feed vector with respect to 100 weight portions, described Sal is 0.5～1.5 weight portion, described calcium bicarbonate is 0.5～1 weight portion, and described mineral is 0.2～1 weight portion, and described vitamin is 0.5～1.5 weight portion, described aminoacid is 1～2 weight portion, and described health-care agent is 0.5～1 weight portion.
7. fodder compound as claimed in claim 5 is characterized in that, described health-care agent is the mixture that Maifanitum, sodium bicarbonate, Fructus Crataegi powder, Montmorillonitum, zeolite powder and bentonite are formed.
8. the preparation method of the described fodder compound of claim 5, it is characterized in that, comprise: the first step, described Chinese medicine composition composition powders, described feed vector and Sal, calcium hydrogen phosphate, mineral, vitamin, aminoacid and health-care agent are mixed, putting into blender stirs, put into pulverizer subsequently and be ground into powder, the powder that obtains is put into dehydrator dry;
In second step, treat that material that the first step obtains is down to put into blender again after the room temperature and stir that it is expanded to put into bulking machine subsequently, the material after expanded is put into the grit machine produce the precipitation hard pellet diet, sieves, and obtains described fodder compound.
9. the preparation method of fodder compound as claimed in claim 8, it is characterized in that: in the described first step, mixing time is 120 minutes～150 minutes in blender, and the aridity of the material in dehydrator after the oven dry is 70%～80%, and the time of smoking is 40～60 minutes;
In described second step, mixing time is 150 minutes～180 minutes in blender, and the aridity of the material after expanded in bulking machine is 85%～95%, and the expanded time is 1 hour～2 hours, and the order number of the fodder compound that the back of sieving obtains is 50 orders～100 orders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210016596 CN102526521B (en) | 2012-01-19 | 2012-01-19 | Traditional Chinese medicine composition powder for treating nephropathogenic infectious bronchitis in chicken |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210016596 CN102526521B (en) | 2012-01-19 | 2012-01-19 | Traditional Chinese medicine composition powder for treating nephropathogenic infectious bronchitis in chicken |
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| CN101773569A (en) * | 2010-03-04 | 2010-07-14 | 河北工程大学 | Oral Chinese medicine liquid for treating chicken infectious laryngotracheitis |
| CN102273551A (en) * | 2010-06-12 | 2011-12-14 | 陕西未来绿色农牧开发有限公司 | Chinese herbal medicinal forage for laying hen and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101773569A (en) * | 2010-03-04 | 2010-07-14 | 河北工程大学 | Oral Chinese medicine liquid for treating chicken infectious laryngotracheitis |
| CN102273551A (en) * | 2010-06-12 | 2011-12-14 | 陕西未来绿色农牧开发有限公司 | Chinese herbal medicinal forage for laying hen and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 南京中医药大学.中药大辞典.《中药大辞典》.上海科学技术出版社,2006,第942、1140、1174、1552、1524、2526、2709、2779页. * |
| 李武卫等.邢月朋分期辨证治疗慢性支气管炎的经验.《河北中医》.2008,第30卷(第7期),第677页最后1段至678页第1段，. |
| 邢月朋分期辨证治疗慢性支气管炎的经验;李武卫等;《河北中医》;20080731;第30卷(第7期);第677页最后1段至678页第1段， * |
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