CN102498118A - 黄病毒科病毒的抑制剂 - Google Patents
黄病毒科病毒的抑制剂 Download PDFInfo
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- CN102498118A CN102498118A CN2010800404113A CN201080040411A CN102498118A CN 102498118 A CN102498118 A CN 102498118A CN 2010800404113 A CN2010800404113 A CN 2010800404113A CN 201080040411 A CN201080040411 A CN 201080040411A CN 102498118 A CN102498118 A CN 102498118A
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- 0 CC(CC1)CCC11C(C2)CC2CC*1 Chemical compound CC(CC1)CCC11C(C2)CC2CC*1 0.000 description 10
- WRMCRYXMORSWSL-HXUWFJFHSA-N CC(C)(C)C#Cc1cc(N(C(CC2)CCC22OCCO2)C([C@@H]2CC=C(C)CC2)=O)c(C(OC)=O)[s]1 Chemical compound CC(C)(C)C#Cc1cc(N(C(CC2)CCC22OCCO2)C([C@@H]2CC=C(C)CC2)=O)c(C(OC)=O)[s]1 WRMCRYXMORSWSL-HXUWFJFHSA-N 0.000 description 1
- HASZTOKTSXBMGF-VAMGGRTRSA-N CC(C)(C)C#Cc1cc(N([C@H](CC2)CC[C@@H]2O)C([C@@H]2CC=C(C)CC2)=O)c(C(OC)=O)[s]1 Chemical compound CC(C)(C)C#Cc1cc(N([C@H](CC2)CC[C@@H]2O)C([C@@H]2CC=C(C)CC2)=O)c(C(OC)=O)[s]1 HASZTOKTSXBMGF-VAMGGRTRSA-N 0.000 description 1
- CCNDHTQRRDLXQJ-UHFFFAOYSA-N CC(C)(C)C#Cc1cc(NC(CC2)CCC22OCCO2)c(C(OC)=O)[s]1 Chemical compound CC(C)(C)C#Cc1cc(NC(CC2)CCC22OCCO2)c(C(OC)=O)[s]1 CCNDHTQRRDLXQJ-UHFFFAOYSA-N 0.000 description 1
- GIAPANOPPGIJKQ-MNOVXSKESA-N CC(C)(COC1=O)[C@H]1OC([C@@H]1CC=C(C)CC1)=O Chemical compound CC(C)(COC1=O)[C@H]1OC([C@@H]1CC=C(C)CC1)=O GIAPANOPPGIJKQ-MNOVXSKESA-N 0.000 description 1
- NZZITUYJLJVUTI-SSDOTTSWSA-N CC(CC1)=CC[C@H]1C(Cl)=O Chemical compound CC(CC1)=CC[C@H]1C(Cl)=O NZZITUYJLJVUTI-SSDOTTSWSA-N 0.000 description 1
- OYOQOLNBTPTFEM-SSDOTTSWSA-N CC(CC1)=CC[C@H]1C(O)=O Chemical compound CC(CC1)=CC[C@H]1C(O)=O OYOQOLNBTPTFEM-SSDOTTSWSA-N 0.000 description 1
- PBFBEYNWOLUTMH-UHFFFAOYSA-N CC(CC1)CC[O]1(OC)=O Chemical compound CC(CC1)CC[O]1(OC)=O PBFBEYNWOLUTMH-UHFFFAOYSA-N 0.000 description 1
- HOBBEYSRFFJETF-SECBINFHSA-N CC([C@@H]1CC=C(C)CC1)=O Chemical compound CC([C@@H]1CC=C(C)CC1)=O HOBBEYSRFFJETF-SECBINFHSA-N 0.000 description 1
- ZJESWEGRJVWTJC-UHFFFAOYSA-N CCOP(C)(C1(CCCCC1)O)=O Chemical compound CCOP(C)(C1(CCCCC1)O)=O ZJESWEGRJVWTJC-UHFFFAOYSA-N 0.000 description 1
- HJWQWLZUTCEUSW-OYDDBQEKSA-N CCOP(C)(Cc(cc1)ccc1-c1cc(N([C@H](CC2)CC[C@@H]2O)C([C@H]2CC[C@H](C)CC2)=O)c(C(OC)=O)[s]1)=O Chemical compound CCOP(C)(Cc(cc1)ccc1-c1cc(N([C@H](CC2)CC[C@@H]2O)C([C@H]2CC[C@H](C)CC2)=O)c(C(OC)=O)[s]1)=O HJWQWLZUTCEUSW-OYDDBQEKSA-N 0.000 description 1
- RXIPHMOMUQJCOI-XPUUQOCRSA-N C[C@@H](C(C)(C)[C@H]1OC(C=C)=O)OC1=O Chemical compound C[C@@H](C(C)(C)[C@H]1OC(C=C)=O)OC1=O RXIPHMOMUQJCOI-XPUUQOCRSA-N 0.000 description 1
- QMRBTIZFOIBOGH-IWFBPKFRSA-N C[C@@H](CC(C)=CC1)[C@H]1C(N([C@H](CC1)CC[C@@H]1O)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@@H](CC(C)=CC1)[C@H]1C(N([C@H](CC1)CC[C@@H]1O)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O QMRBTIZFOIBOGH-IWFBPKFRSA-N 0.000 description 1
- HETMKSQFLULCKN-VIFPVBQESA-N C[C@@]1(CC=C(C)CC1)C(O)=O Chemical compound C[C@@]1(CC=C(C)CC1)C(O)=O HETMKSQFLULCKN-VIFPVBQESA-N 0.000 description 1
- BDUOPLPCMUBBLM-FKLFNDOTSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1O)c1c(C(O)=O)[s]c(-c2ccc(CP(C)(O)=O)cc2)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1O)c1c(C(O)=O)[s]c(-c2ccc(CP(C)(O)=O)cc2)c1)=O BDUOPLPCMUBBLM-FKLFNDOTSA-N 0.000 description 1
- JHIVVAPYMSGYDF-UHFFFAOYSA-N O=C1CCCCC1 Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65681—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a (thio)phosphinic acid or ester thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24087409P | 2009-09-09 | 2009-09-09 | |
| US61/240,874 | 2009-09-09 | ||
| PCT/US2010/047983 WO2011031669A1 (en) | 2009-09-09 | 2010-09-07 | Inhibitors of flaviviridae viruses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102498118A true CN102498118A (zh) | 2012-06-13 |
Family
ID=43028061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800404113A Pending CN102498118A (zh) | 2009-09-09 | 2010-09-07 | 黄病毒科病毒的抑制剂 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8501714B2 (enExample) |
| EP (1) | EP2507249B1 (enExample) |
| JP (1) | JP5774008B2 (enExample) |
| KR (1) | KR20120081123A (enExample) |
| CN (1) | CN102498118A (enExample) |
| AU (1) | AU2010292411B2 (enExample) |
| BR (1) | BR112012005438A2 (enExample) |
| CA (1) | CA2771124C (enExample) |
| ES (1) | ES2559437T3 (enExample) |
| IN (1) | IN2012DN01855A (enExample) |
| MX (1) | MX2012002925A (enExample) |
| NZ (1) | NZ598208A (enExample) |
| PT (1) | PT2507249E (enExample) |
| WO (1) | WO2011031669A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101330547A (zh) * | 2007-06-20 | 2008-12-24 | 朗迅科技公司 | 在VoIP网络中分布的用于提供服务的媒体资源 |
| DK2475657T3 (da) | 2009-07-21 | 2013-09-23 | Gilead Sciences Inc | 5-Alkynylthien-2-ylcarboxylsyrer som inhibitorer af flaviviridae-vira |
| KR20120081123A (ko) * | 2009-09-09 | 2012-07-18 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리대 바이러스의 억제제 |
| ES2626150T3 (es) | 2010-01-15 | 2017-07-24 | Gilead Sciences, Inc. | Inhibidores de virus flaviviridae |
| NZ600816A (en) * | 2010-01-15 | 2014-08-29 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| WO2012006060A1 (en) * | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| MA34462B1 (fr) | 2010-07-22 | 2013-08-01 | Novartis Ag | Composes de thiophene 2,3,5- trisubstitues et leurs utilisations |
| US20130203706A1 (en) * | 2011-06-28 | 2013-08-08 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| PT2734515E (pt) | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US8759544B2 (en) * | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| KR102626210B1 (ko) | 2017-12-07 | 2024-01-18 | 에모리 유니버시티 | N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004052885A1 (en) * | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| CN1602308A (zh) * | 2001-06-11 | 2005-03-30 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
| WO2008058393A1 (en) * | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861421A (en) | 1995-12-21 | 1999-01-19 | Smithkline Beecham Corporation | 4,4-(disubstituted) cyclohexan-1-one monomers and related compounds |
| US20050119332A1 (en) | 1998-03-12 | 2005-06-02 | Lone Jeppesen | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) |
| US20020002199A1 (en) | 1998-03-12 | 2002-01-03 | Lone Jeppesen | Modulators of protein tyrosine phosphatases (ptpases) |
| JP2005500287A (ja) | 2001-06-11 | 2005-01-06 | シャイアー バイオケム インコーポレイテッド | Ｆｌａｖｉｖｉｒｕｓ感染の処置または予防のための化合物および方法 |
| CN100413861C (zh) | 2002-12-10 | 2008-08-27 | 维勒凯姆制药股份有限公司 | 用于治疗或预防黄病毒感染的化合物 |
| DE10359791A1 (de) | 2003-12-19 | 2005-07-21 | Bayer Healthcare Ag | Substituierte Thiophene |
| WO2005081954A2 (en) | 2004-02-25 | 2005-09-09 | Wyeth | Inhibitors of protein tyrosine phosphatase 1b |
| EP1732919A1 (en) | 2004-03-30 | 2006-12-20 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| DE102005028077A1 (de) | 2004-12-22 | 2006-07-13 | Aicuris Gmbh & Co. Kg | Alkinyl-substituierte Thiophene |
| DE102004061746A1 (de) | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| BRPI0610283A2 (pt) | 2005-05-13 | 2010-10-19 | Virochem Pharma Inc | composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica |
| TW200801022A (en) | 2006-02-15 | 2008-01-01 | Sanofi Aventis | Novel amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments |
| JP2010510191A (ja) | 2006-11-17 | 2010-04-02 | スミスクライン ビーチャム コーポレーション | 抗ウイルス剤としての２−カルボキシチオフェン誘導体 |
| AU2009322400A1 (en) | 2008-12-03 | 2011-06-30 | Presidio Pharmaceuticals, Inc. | Inhibitors of HCV NS5A |
| DK2475657T3 (da) | 2009-07-21 | 2013-09-23 | Gilead Sciences Inc | 5-Alkynylthien-2-ylcarboxylsyrer som inhibitorer af flaviviridae-vira |
| KR20120081123A (ko) * | 2009-09-09 | 2012-07-18 | 길리애드 사이언시즈, 인코포레이티드 | 플라비비리대 바이러스의 억제제 |
| WO2011068715A1 (en) | 2009-11-25 | 2011-06-09 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
| ES2626150T3 (es) | 2010-01-15 | 2017-07-24 | Gilead Sciences, Inc. | Inhibidores de virus flaviviridae |
| NZ600816A (en) | 2010-01-15 | 2014-08-29 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| AU2011276526A1 (en) | 2010-06-28 | 2013-01-10 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| PT2734515E (pt) | 2011-07-13 | 2016-03-11 | Gilead Sciences Inc | Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae |
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2010
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- 2010-09-07 BR BR112012005438A patent/BR112012005438A2/pt not_active IP Right Cessation
- 2010-09-07 NZ NZ598208A patent/NZ598208A/en not_active IP Right Cessation
- 2010-09-07 ES ES10763902.3T patent/ES2559437T3/es active Active
- 2010-09-07 US US13/392,467 patent/US8501714B2/en active Active
- 2010-09-07 WO PCT/US2010/047983 patent/WO2011031669A1/en not_active Ceased
- 2010-09-07 CN CN2010800404113A patent/CN102498118A/zh active Pending
- 2010-09-07 MX MX2012002925A patent/MX2012002925A/es active IP Right Grant
- 2010-09-07 PT PT107639023T patent/PT2507249E/pt unknown
- 2010-09-07 CA CA2771124A patent/CA2771124C/en not_active Expired - Fee Related
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1602308A (zh) * | 2001-06-11 | 2005-03-30 | 病毒化学医药公司 | 用作黄病毒感染抗病毒剂的噻吩衍生物 |
| WO2004052885A1 (en) * | 2002-12-10 | 2004-06-24 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| WO2008058393A1 (en) * | 2006-11-15 | 2008-05-22 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of flavivirus infections |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010292411B2 (en) | 2015-04-09 |
| PT2507249E (pt) | 2016-02-15 |
| JP2013504576A (ja) | 2013-02-07 |
| KR20120081123A (ko) | 2012-07-18 |
| MX2012002925A (es) | 2012-08-03 |
| BR112012005438A2 (pt) | 2018-03-20 |
| NZ598208A (en) | 2014-02-28 |
| EP2507249A1 (en) | 2012-10-10 |
| US20120156166A1 (en) | 2012-06-21 |
| AU2010292411A1 (en) | 2012-03-15 |
| US8501714B2 (en) | 2013-08-06 |
| JP5774008B2 (ja) | 2015-09-02 |
| EP2507249B1 (en) | 2015-11-11 |
| US20130302280A1 (en) | 2013-11-14 |
| US8765722B2 (en) | 2014-07-01 |
| IN2012DN01855A (enExample) | 2015-08-21 |
| WO2011031669A1 (en) | 2011-03-17 |
| CA2771124C (en) | 2019-01-15 |
| HK1170740A1 (zh) | 2013-03-08 |
| CA2771124A1 (en) | 2011-03-17 |
| ES2559437T3 (es) | 2016-02-12 |
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Application publication date: 20120613 |