CN102488715B - Natural oral cavity disinfectant and preparation method thereof - Google Patents
Natural oral cavity disinfectant and preparation method thereof Download PDFInfo
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- CN102488715B CN102488715B CN2011104178688A CN201110417868A CN102488715B CN 102488715 B CN102488715 B CN 102488715B CN 2011104178688 A CN2011104178688 A CN 2011104178688A CN 201110417868 A CN201110417868 A CN 201110417868A CN 102488715 B CN102488715 B CN 102488715B
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- purified water
- tannin
- gallic acid
- cavity disinfectant
- monosaccharide
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Abstract
The invention provides natural oral cavity disinfectant, which comprises, by weight percentage, from 0.4% to 0.8% of gallotannic acid, from 0.2% to 0.6% of gallic acid, from 0.5% to 0.8% monosaccharide and the balance purified water. Gallnut is coarsely crushed, is digested by water at the temperature of 40 DEG C for 10 hours to 12 hours, and is filtered, digested and coarsely filtered liquor is finely filtered via a sanitary micro-strainer, and obtained mother liquor is diluted by purified water, so that the natural oral cavity disinfectant is obtained. The natural oral cavity disinfectant tastes comfortable and sweet slightly, and is safe and effective. Functional components are clear and controllable. The natural oral cavity disinfectant is quickly effective for dental ulcer, periodontitis and toothache.
Description
Technical field
The present invention relates to a kind of health care products, specifically, is a kind of natural oral cavity disinfectant that extracts preparation take the Chinese medicine Galla Chinensis as raw material.
Background technology
Oral hygiene is the important health care of Modern human populations." illness finds its way in by the mouth ", human oral cavity because of breathe and food residual, cause the various diseases such as oral ulcer, dental caries, pharyngolaryngitis, periodontitis and upper respiratory tract infection, have a strong impact on the healthy of people, oral hygiene becomes prophylactic important door.
The oral cavity disinfecting liquid product of using clinically at present mainly contains iodine class, fluoride preparation class, antibiotics, drug chemical class and herbal mixture class.In existing oral disinfecting liquid product the many kinds of chemical classes be corrosive, zest and toxic and side effects, the difficult control of the not clear quality of the many kind compositions of herbal mixture class, the public wishes to seek a kind of both environmental protection, safe, comfortable, simultaneously bactericidal anti-inflammatory effect good natural oral cavity disinfectant again.
Natural drug and the parts of generic medicinal plants of characteristic that to be that China is distinctive have Galla Chinensis " the worm summer in winter doubly ".Modern pharmacology and clinical research show, the medicinal main effective site of Galla Chinensis is gallotannic acid (industrial habit title tannin), content〉62.0%, have all multiactions such as convergence, antibacterial, blood coagulation; Main effective medicinal components is the gallic acid that the gallotannic acid hydrolysis produces, content〉50.0%, having many-sided pharmacological actions such as stronger antibiotic, antiinflammatory, antiviral, antifungal, antioxidation, antitumor, antiallergic, antimutagenic, hemostasis, convergence, function of gallbladder promoting, is the precursor of synthetic multiple biologically active drug.
Aspect the oral hygiene natural drug screening, what most study was the warmmest at present is Galla Chinensis, studies show that Galla Chinensis extract can suppress the generation of multiple oral cavity bacterium metabolism acid comprehensively, significantly suppresses the generation of the outer water-insoluble polysaccharide of Streptococcus mutans born of the same parents; Stronger inhibition enamel decalcification effect is arranged, and its anticaries activity composition is mainly gallic acid and ester type compound; By suppressing the oral cavity bacterium growth, produce acid, producing the approach such as extracellular matrix, suppress and kill the oral biological film antibacterial; The hygiene and health products such as Galla Chinensis toothpaste are put on market.
Summary of the invention
The object of the present invention is to provide a kind of membrane separation technique based on environmental protection, extract method and the product for preparing natural oral cavity disinfectant from the natural drug Galla Chinensis.Its constant product quality, comfortable taste, safe and effective, functional component is clear and definite controlled.
Natural oral cavity disinfectant provided by the invention, it contains the component of following percentage by weight: tannin 0.4～0.8%, gallic acid 0.2～0.6%, monosaccharide 0.5～0.8%, purified water to 100%, described monosaccharide is glucose.
Its preparation method can be that said components is mixed.
What optimize is to be made by the method that comprises the following steps:
(1) with the Galla Chinensis coarse crushing, cross 60 mesh sieves, remove times aphid and secretions, the clean material of times shell is standby;
(2) the clean material of times shell was eluriated 5～10 minutes with purified water, drained;
(3) will clean times shell that drains and only expect to drop in extraction pot, and add times shell only to expect the purified water of 5～6 times of weight, and control 40 ℃ of extraction temperatures, extraction time 10～12 hours is crossed 400 mesh sieve filters, gets lixiviate coarse filtration liquid;
(4) lixiviate coarse filtration liquid is crossed the sanitation-grade microstrainer, filtering accuracy 0.25 μ m, and membrane module material polypropylene, operating pressure 0.5～1MPa gets Galla Chinensis oral-cavity disinfectant mother solution;
(5) sampling detects density, Baume degrees, soluble solid and tannin, gallic acid, the contents of monosaccharides of Galla Chinensis oral-cavity disinfectant mother solution, and tinning is temporary;
(6) mother solution is diluted several times with purified water, the weight percent concentration of tannin, gallic acid, monosaccharide is tannin 0.4～0.8%, gallic acid 0.2～0.6%, monosaccharide 0.5～0.8% to the solution, then packing.
In step (3), filter gained and consider the purified water secondary lixiviate 6～8 hours that slag adds 4～5 times of weight, cross 400 mesh sieves filters, merging filtrate.
The specific embodiment
Embodiment 1: remove except the Galla Chinensis Chinese Nut-gall of times aphid and secretions and only expect 10kg, the clean material of times shell was eluriated 10 minutes with purified water, drain, drop in the 100L extraction pot, add purified water 60L, control 40 ℃ of extraction temperatures, extraction time 10 hours is crossed 400 mesh sieve filters, and filtrate pumps into basin; Add 500L purified water secondary lixiviate 6 hours, cross 400 mesh sieve filters, merging filtrate gets Galla Chinensis lixiviating solution 103.5L; Lixiviating solution is crossed the sanitation-grade microstrainer, filtering accuracy 0.25 μ m, and operating pressure 0.5MPa gets Galla Chinensis oral-cavity disinfectant mother solution 96L.The mother solution sampling, sample detects monosaccharide by " LY/T 1642-2005 tannin analytical test method ", " LY/T1644-2005 gallic acid analytical test method " and high-efficient liquid phase technique.Testing result: density 1.027, Baume degrees 4, soluble solid 7.58, tannin 53.13g/L, gallic acid 22.35g/L, monosaccharide 76.33g/L.Mother solution with 10 times of purified water dilutions, was stirred 10 minutes, and sampling is rechecked, tannin 4.13g/L, and gallic acid 3.35g/L, monosaccharide 7.2g/L with the packing of 450ml polyester bottles, is finished product.
Embodiment 2: remove except the Galla Chinensis Potanin Sumac Nut-gall of times aphid and secretions and only expect 10kg, the clean material of times shell was eluriated 10 minutes with purified water, drain, drop in the 100L extraction pot, add purified water 50L, control 40 ℃ of extraction temperatures, extraction time 12 hours is crossed 400 mesh sieve filters, and filtrate pumps into basin; Add 40L purified water secondary lixiviate 6 hours, cross 400 mesh sieve filters, merging filtrate gets Galla Chinensis lixiviating solution 83.2L; Lixiviating solution is crossed the sanitation-grade microstrainer, filtering accuracy 0.25 μ m, and operating pressure 0.5MPa gets Galla Chinensis oral-cavity disinfectant mother solution 78.6L.The mother solution sampling detects, testing result density 1.032, Baume degrees 4.5, soluble solid 8.42, tannin 48.86g/L, gallic acid 31.06g/L, monosaccharide 56.33g/L.Mother solution with 10 times of purified water dilutions, was stirred 10 minutes, and sampling is rechecked, tannin 4.52g/L, and gallic acid 3.02g/L, monosaccharide 5.9g/L with the packing of 450ml polyester bottles, is finished product.
Above product is on probation through the volunteer, and day gargles 3～5 times, generally reacts comfortable taste each 20～30 seconds, and aftertaste is little sweet, and oral ulcer, periodontitis and toothache are had immediate effect.
Claims (3)
1. a natural oral cavity disinfectant, is characterized in that, it contains the component of following percentage by weight: tannin 0.4～0.8%, and gallic acid 0.2～0.6%, monosaccharide 0.5～0.8%, purified water to 100%, made by the method that comprises the following steps:
(1) with the Galla Chinensis coarse crushing, cross 60 mesh sieves, remove times aphid and secretions, the clean material of times shell is standby;
(2) the clean material of times shell was eluriated 5～10 minutes with purified water, drained;
(3) will clean times shell that drains and only expect to drop in extraction pot, and add times shell only to expect the purified water of 5～6 times of weight, and control 40 ℃ of extraction temperatures, extraction time 10～12 hours is crossed 400 mesh sieve filters, gets lixiviate coarse filtration liquid;
(4) lixiviate coarse filtration liquid is crossed the sanitation-grade microstrainer, filtering accuracy 0.25 μ m, and membrane module material polypropylene, operating pressure 0.5～1MPa gets Galla Chinensis oral-cavity disinfectant mother solution;
(5) sampling detects density, Baume degrees, soluble solid and tannin, gallic acid, the contents of monosaccharides of Galla Chinensis oral-cavity disinfectant mother solution, and tinning is temporary;
(6) mother solution is diluted several times with purified water, the weight percent concentration of tannin, gallic acid, monosaccharide is tannin 0.4～0.8%, gallic acid 0.2～0.6%, monosaccharide 0.5～0.8% to the solution, then packing.
2. the preparation method of a natural oral cavity disinfectant, is characterized in that, comprises the following steps:
(1) with the Galla Chinensis coarse crushing, cross 60 mesh sieves, remove times aphid and secretions, the clean material of times shell is standby;
(2) the clean material of times shell was eluriated 5～10 minutes with purified water, drained;
(3) will clean times shell that drains and only expect to drop in extraction pot, and add times shell only to expect the purified water of 5～6 times of weight, and control 40 ℃ of extraction temperatures, extraction time 10～12 hours is crossed 400 mesh sieve filters, gets lixiviate coarse filtration liquid;
(4) lixiviate coarse filtration liquid is crossed the sanitation-grade microstrainer, filtering accuracy 0.25 μ m, and membrane module material polypropylene, operating pressure 0.5～1MPa gets Galla Chinensis oral-cavity disinfectant mother solution;
(5) sampling detects density, Baume degrees, soluble solid and tannin, gallic acid, the contents of monosaccharides of Galla Chinensis oral-cavity disinfectant mother solution, and tinning is temporary;
(6) mother solution is diluted several times with purified water, the weight percent concentration of tannin, gallic acid, monosaccharide is tannin 0.4～0.8%, gallic acid 0.2～0.6%, monosaccharide 0.5～0.8% to the solution, then packing.
3. the preparation method of natural oral cavity disinfectant according to claim 2, is characterized in that, in step (3), filters the purified water secondary lixiviate 6～8 hours that the gained filtering residue adds 4～5 times of weight, crosses 400 mesh sieves filters, merging filtrate.
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| CN2011104178688A CN102488715B (en) | 2011-12-15 | 2011-12-15 | Natural oral cavity disinfectant and preparation method thereof |
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| CN2011104178688A CN102488715B (en) | 2011-12-15 | 2011-12-15 | Natural oral cavity disinfectant and preparation method thereof |
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| CN102488715B true CN102488715B (en) | 2013-05-15 |
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| CN109745354A (en) * | 2019-03-28 | 2019-05-14 | 叶绿芝生物科技（中山）有限公司 | A kind of dental ulcer treatment agent |
| CN110279718B (en) * | 2019-05-27 | 2021-06-18 | 山东消博士消毒科技股份有限公司 | Oral cavity disinfectant manufacturing installation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102127125A (en) * | 2011-01-05 | 2011-07-20 | 中国林业科学研究院林产化学工业研究所 | Multielement combined purification preparation process of refined tannic acid serie and combined preparation of products |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102127125A (en) * | 2011-01-05 | 2011-07-20 | 中国林业科学研究院林产化学工业研究所 | Multielement combined purification preparation process of refined tannic acid serie and combined preparation of products |
Non-Patent Citations (8)
| Title |
|---|
| 中药五倍子在口腔医学中的应用研究新进展;邹群等;《天津中医药》;20081031;第25卷(第5期);439-440 * |
| 五倍子对口内菌斑生物膜活性影响的体外研究;席清平等;《实用口腔医学杂志》;20060331;第22卷(第2期);203-206 * |
| 五倍子水提取物对菌斑生物膜形成过程中表面形态的影响;王瑞等;《牙体牙髓牙周病学杂志》;20071231;第17卷(第7期);383-386 * |
| 天然药物五倍子提取物对致龋菌生长的影响;谢倩等;《华西口腔医学杂志》;20050228;第23卷(第1期);82-84 * |
| 席清平等.五倍子对口内菌斑生物膜活性影响的体外研究.《实用口腔医学杂志》.2006,第22卷(第2期),203-206. |
| 王瑞等.五倍子水提取物对菌斑生物膜形成过程中表面形态的影响.《牙体牙髓牙周病学杂志》.2007,第17卷(第7期),383-386. |
| 谢倩等.天然药物五倍子提取物对致龋菌生长的影响.《华西口腔医学杂志》.2005,第23卷(第1期),82-84. |
| 邹群等.中药五倍子在口腔医学中的应用研究新进展.《天津中医药》.2008,第25卷(第5期),439-440. |
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