CN102488281B - Novel pure plant composite concentrated drinking liquid with blood sugar reducing effect, and preparation method thereof - Google Patents
Novel pure plant composite concentrated drinking liquid with blood sugar reducing effect, and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a health functional drinking liquid, in particular to a pure plant composite concentrated drinking liquid with a blood sugar reducing effect. The pure plant composite concentrated drinking liquid is mainly prepared from the following raw materials in part by weight: 25 to 40 parts of bitter gourd, 15 to 30 parts of kudzu root, 10 to 25 parts of folium mori, 5 to 20 parts of tartary buckwheat and 5 to 20 parts of corn silk. The formula is scientific and reasonable, an extraction process is advanced, pure plant essence is concentrated, the blood sugar reducing effect is obvious, and side effects are avoided. The invention also provides a method for preparing the pure plant composite concentrated drinking liquid.
Description
Technical field:
The present invention relates to a kind of health function drink, particularly there is the compound concentrating drinking liquid of pure plant of hypoglycemic activity, also relate in addition the method for making of drink.
Background technology:
Diabetes are a kind of incretion diseases that metabolic disorder is main manifestations of take, and are by insulin in body definitely or relative deficiency and the metabolic disorder of the sugar that causes, fat, protein.In early days can be asymptomatic, when blood sugar is too high, can there is three-many-one-little symptom: many drink, many foods, diuresis and lose weight.Often follow multiple chronic complicating diseases, cause the extensive injuries of many organs, multisystem.The feature with high fatal rate, high disability rate and high medical treatment cost, it is the Chronic Non-Communicable Diseases of the third-largest serious threat human health after tumour, vascular lesion.
Recently decades, global diabetes number of patients is increasing rapidly with surprising rapidity, and diabetes have become worldwide a kind of epidemic disease of 21 century.The epidemiology survey demonstration of 2003, there are nearly 200,000,000 diabetics in the whole world, and this numeral will be increased to over 300,000,000 to estimate 2025.Along with the fast development of China's economy, the ill number of diabetes also presents growth at full speed.2008, diabetes mellitus in China association and organization has carried out 15 cities, the whole nation and regional onset diabetes condition survey, find that Chinese onset diabetes rate is up to 9.7%, estimate that accordingly national diabetic approximately has 9,240 ten thousand people, investigation result like this, the onset diabetes number of China has surpassed India and the U.S. at present, becomes the first in the world diabetes big country.
Diabetes are the same with hypertension, once obtain, are to need throughout one's life to safeguard and treat.Drug therapy can be controlled blood sugar and diabetic complication effectively.Diabetic is divided into insulin preparation and orally-taken blood sugar reducing medicine, and OHA is divided into again Western medicine Drugs Promoting Insulin Secretion (as sulfonylurea, meglitinide), non-Drugs Promoting Insulin Secretion (as alpha-glucosidase inhibitor, biguanides etc.) and blood-sugar lowering tcm drug.But no matter the hypoglycemic medicine of which class starts to control preferably blood sugar, prolonged application but easily produces resistance, and large to the side effect of the organs such as stomach, liver, kidney.So the treatment of diabetes should be integrated as good with dietary therapy, suitable exercise and drug therapy.Therefore, develop a compound concentrating drinking liquid of Novel pure plant with blood sugar reducing function, for diabetic, from dietary therapy aspect, its meaning is very great.
Summary of the invention:
The object of the invention is for overcoming the deficiency of prior art and product, a kind of compound concentrating drinking liquid of Novel pure plant with hypoglycemic activity is provided, scientific formulation rationally, concentrated pure plant essence, effect of lowering blood sugar be remarkable, and without any side effects.Another object of the present invention is to provide a kind of method for making with the compound concentrating drinking liquid of Novel pure plant of hypoglycemic activity, and extraction process is advanced, and handling safety is simple.
The object of the invention is achieved by the following technical programs: a kind of compound concentrating drinking liquid of Novel pure plant with hypoglycemic activity, and mainly the raw material by following weight parts forms:
Balsam pear 25-40 root of kudzu vine 15-30
The bitter buckwheat 5-20 of mulberry leaf 10-25
Corn stigma 5-20;
Method for making comprises pretreatment, prepares extract and preparation:
First step pretreatment: seed, section, oven dry are cleaned, gone to bright balsam pear, makes dried Frutus Momordicae Charantiae;
Second step is prepared ethanol extract: by formulation weight, take dried Frutus Momordicae Charantiae, the root of kudzu vine, mulberry leaf and be ground into 60 object meal, each raw material after pulverizing is mixed, add mixed material weight 12-15 60%-70% ethanol doubly, then in ultrasonic Dynamic Extraction mode, prepare ethanol extract;
The 3rd step is prepared water extract-alcohol precipitation extract: by formulation weight, take bitter buckwheat, corn stigma, add the deionized water of 8 times after pulverizing, heating decocts 1 hour, three times like this, after decoction liquor is merged, with ethanol sedimentation, standing filtration, prepares water extract-alcohol precipitation extract;
The 4th step preparation: the extract of second step and the 3rd step is merged, and then decompression distillation, concentrated making without alcohol concentrate, make pure plant concentrating drinking liquid.
Described concentrating drinking liquid is preferably comprised of the raw material of following weight parts:
Balsam pear 30-35 root of kudzu vine 20-25
The bitter buckwheat 10 of mulberry leaf 15-20
Corn stigma 10.
The method for making of concentrating drinking liquid of the present invention comprises pretreatment, prepares extract and preparation:
First step pretreatment: seed, section, oven dry are cleaned, gone to bright balsam pear, makes dried Frutus Momordicae Charantiae;
Second step is prepared ethanol extract: by formulation weight, take dried Frutus Momordicae Charantiae, the root of kudzu vine, mulberry leaf and be ground into the meal about 60 orders, each raw material after pulverizing is mixed, add mixed material weight 12-15 60%-70% ethanol doubly, then in ultrasonic Dynamic Extraction mode, prepare ethanol extract;
The 3rd step is prepared water extract-alcohol precipitation extract: by formulation weight, take bitter buckwheat, corn stigma, add the deionized water of 8 times after pulverizing, heating decocts 1 hour, three times like this, after decoction liquor is merged, with ethanol sedimentation, standing filtration, prepares water extract-alcohol precipitation extract;
The 4th step preparation: the extract of second step and the 3rd step is merged, and then decompression distillation, concentrated making without alcohol concentrate, make pure plant concentrating drinking liquid.
Eating method: get concentrating drinking liquid 8-10 of the present invention and drip, be added in the pure water of a glass approximately 200 milliliters, drinkable after stirring evenly; Twice of every day.
The active ingredient of concentrating drinking liquid of the present invention all comes from pure natural plant raw material.Modern study confirms: balsam pear nutrient is abundant, is rich in protein, alkaloid, organic acid, trace element and multiple bioactive ingredients, has the effect of diuresis, heat-clearing, improving eyesight removing toxic substances, hypoglycemic, reducing blood lipid and raising immunity of organisms.Wherein the antidiabetic effect of balsam pear is one of its most important function.Have in recent years scholar to propose the concept of bitter gourd sugar-reducing peptide, think that balsam pear contains the polypeptide of a species specificity para-insulin, main component is charantin, balsam pear peptide and alkaloid.And balsam pear not only has direct hypoglycemic effect, diabetic complication is had to therapeutic action.The root of kudzu vine is a kind of tradition and ancient medicinal and edible Chinese medicine is rich in osajin, root of kudzu vine glycoside, triterpene saponin, alkaloid and other compound, have relieve the effect of alcohol, anti-oxidant, hypoglycemic, reducing blood lipid, the diastole cerebrovascular and improve the effect of immunity.In the active ingredient of the root of kudzu vine, of greatest concern is osajin, is also its main active.By animal model experiment, find that kudzu root flavone can obviously improve the pathological symptom of diabetic mice, reduce blood sugar level, reduce the content of fructosamine, sorbierite, aldose reductase and AGEs (non-glycosylation dead end product) in blood, the content of SDH in blood is raise.Experimental study also finds that Puerarin can suppress the Apoptosis of Human Umbilical Vein Endothelial of high glucose and high fat induction, and thinks that this mechanism brought into play effect in preventing and treating diabetes and artery sclerosis complication process.Various countries scholar has carried out large quantity research to mulberry leaf in recent years, finds to contain the multiple bioactive ingredients such as flavone compound, volatile oil, amino acid, mulberry leaf polysaccharide in mulberry leaf.Modern pharmacology studies have shown that flavones in mulberry leaves passes through Antioxidation Mechanism, remove free radical, keep insulin β eucaryotic cell structure complete, maintain its physiological function, thereby reduce diabetic's blood sugar level, and prevent the generation of complication, and mulberry leaf polysaccharide reduces the mechanism of action of blood sugar, blood fat and rising insulin level, being the impact of hormonal readiness on the one hand, is to promote insulin secretion and repair insulin β cell on the other hand.Therefore mulberry leaf have the effect of obvious inhibition blood sugar rising.Bitter buckwheat is also a kind of nutritious medicine-food two-purpose pollution-free food, mainly contains the various trace elements such as flavonoids, amino acid, organic acid, polypeptide, protein and magnesium, selenium.Some medical institutions on the ground such as Beijing, Tianjin, Sichuan in recent years a large amount of clinical observation and animal experiment prove that bitter buckwheat is hypoglycemic, hypolipemic function is remarkable, can be used to the diseases such as prevention and adjuvant therapy of diabetes, high fat of blood and hypertension.It is relevant that experimental study shows that the hypoglycemic activity of bitter buckwheat mainly contains the bioactive ingredients such as bitter buckwheat flavone, DCI, steroid saponin with it.Corn stigma is one of time-honored Chinese medicine of China, contains the multiple chemical composition useful to human body: as flavones and glycoside, carbohydrate, organic acid, alkaloid, various trace elements and vitamin.Modern pharmacological research confirms that corn stigma has hypoglycemic, reducing blood lipid, inducing diuresis to reduce edema, the effect such as antibacterial, hypotensive.With diabetic mice due to alloxan, do experiment, research finds that corn stigma has good therapeutic action to it, and the hyperglycaemia that corn silk water extract causes adrenaline and glucose also has good effect, and the fermentation preparation of corn stigma is also stronger to the hypoglycemic activity of rabbit.
Therefore to take balsam pear, the root of kudzu vine, mulberry leaf, bitter buckwheat, corn stigma be raw material to the compound concentrating drinking liquid of the pure plant of the present invention, through modern extraction process, refine and form, concentrated pure plant essence, avoided that the traditional traditional Chinese medicine usage of above-mentioned raw materials is loaded down with trivial details, taste is not good enough and the active component shortcoming such as serious that runs off, have that mouthfeel is good, nutritious, blood-sugar decreasing active content is high, function of reducing blood sugar is remarkable, without any side effects and edible feature easy to carry, market prospects are wide.
The specific embodiment:
Below in conjunction with the specific embodiment, the present invention is described in further detail, but the invention is not restricted to specific embodiment.
Embodiment 1:
A pure plant concentrating drinking liquid for hypoglycemic activity, by following weight (gram) raw material make:
Balsam pear 40 roots of kudzu vine 20
The bitter buckwheat 15 of mulberry leaf 10
Corn stigma 10.
First step pretreatment: seed, section, oven dry are cleaned, gone to bright balsam pear, makes dried Frutus Momordicae Charantiae;
Second step is prepared ethanol extract: by formulation weight, take 40 grams of dried Frutus Momordicae Charantiaes, 20 grams of the roots of kudzu vine, 10 grams, mulberry leaf and be ground into the meal about 60 orders, each raw material after pulverizing is mixed, 60% ethanol that adds 15 times of mixed material weight, then prepares ethanol extract in ultrasonic Dynamic Extraction mode;
The 3rd step is prepared water extract-alcohol precipitation extract: by formulation weight, take 15 grams of bitter buckwheats, 10 grams of corn stigmas, the deionized water that adds 8 times after pulverizing, heating decocts 1 hour, three times like this, after decoction liquor is merged, with ethanol sedimentation, standing filtration, prepares water extract-alcohol precipitation extract;
The 4th step preparation: the extract of second step and the 3rd step is merged, and then decompression distillation, concentrated making without alcohol concentrate, make pure plant concentrating drinking liquid.
Embodiment 2:
According to the method described in embodiment 1, prepare pure plant concentrating drinking liquid, each raw material weight (gram) component is:
Balsam pear 30 roots of kudzu vine 25
The bitter buckwheat 20 of mulberry leaf 15
Corn stigma 15.
Embodiment 3:
According to the method described in embodiment 1, prepare the compound concentrating drinking liquid of pure plant, each raw material weight (gram) component is:
Balsam pear 25 roots of kudzu vine 30
The bitter buckwheat 18 of mulberry leaf 20
Corn stigma 10.
Embodiment 4:
According to the method described in embodiment 1, prepare the compound concentrating drinking liquid of pure plant, each raw material weight (gram) component is:
Balsam pear 35 roots of kudzu vine 15
The bitter buckwheat 5 of mulberry leaf 20
Corn stigma 20.
Embodiment 5:
According to the method described in embodiment 1, prepare pure plant concentrating drinking liquid, each raw material weight (gram) component is:
Balsam pear 30 roots of kudzu vine 30
The bitter buckwheat 20 of mulberry leaf 15
Corn stigma 5.
The eating method of above-described embodiment 1-5 drink: get concentrating drinking liquid 8-10 of the present invention and drip, be added in the pure water of a glass approximately 200 milliliters, drinkable after stirring evenly, twice of every day.
Utilize the above-mentioned a kind of compound concentrating drinking liquid of pure plant and the using method with hypoglycemic activity making, by 55 routine type ii diabetes patient trial state are carried out to observation analysis, treated effect reaches 96.37%.
The clinical judgment of concrete treated effect is according to being:
Example 1: the routine type ii diabetes patient of mother Wang etc. 22, use front fasting blood-glucose (FBG) 7.5mmol/L of drink of the present invention left and right, postprandial blood sugar (PBG) 9.0mmol/L left and right, drank concentrating drinking liquid of the present invention after 2 weeks, and fasting blood-glucose can be controlled at below 6.1mmol/L.Postprandial blood sugar (PBG) 7.5mmol/L left and right.Drink concentrating drinking liquid of the present invention approximately three years so far later always, can completely no longer take orally-taken blood sugar reducing medicine, fasting blood-glucose index is normal.
Example 2: the routine type ii diabetes patient of Bai etc. 31, take at ordinary times hypoglycemic medicine fasting blood-glucose still higher, through the 7mmol/L left and right of being everlasting, sometimes even up to more than 10mmol/L, by drinking concentrating drinking liquid 3-4 week of the present invention, fasting blood-glucose (FBG) has been down to below 6.0mmol/L, drinks continuously after 1 month and starts suitably to reduce orally-taken blood sugar reducing medicine consumption, and adhere to the blood sugar of testing oneself for three days one time.Adhere to drinking the concentrating drinking liquid of the present invention time approximately more than a year, orally-taken blood sugar reducing medicine is all by original every day three times, is down to once a day now, and each consumption is the same, and fasting blood-glucose can be controlled at the normal level below 6mmol/L.
Claims (3)
1. the compound concentrating drinking liquid of Novel pure plant with hypoglycemic activity, is characterized in that: it is mainly made by the raw material of following weight parts:
Balsam pear 25-40 root of kudzu vine 15-30
The bitter buckwheat 5-20 of mulberry leaf 10-25
Corn stigma 5-20;
Method for making comprises pretreatment, prepares extract and preparation:
First step pretreatment: seed, section, oven dry are cleaned, gone to bright balsam pear, makes dried Frutus Momordicae Charantiae;
Second step is prepared ethanol extract: by formulation weight, take dried Frutus Momordicae Charantiae, the root of kudzu vine, mulberry leaf and be ground into 60 object meal, each raw material after pulverizing is mixed, add mixed material weight 12-15 60%-70% ethanol doubly, then in ultrasonic Dynamic Extraction mode, prepare ethanol extract;
The 3rd step is prepared water extract-alcohol precipitation extract: by formulation weight, take bitter buckwheat, corn stigma, add the deionized water of 8 times after pulverizing, heating decocts 1 hour, three times like this, after decoction liquor is merged, with ethanol sedimentation, standing filtration, prepares water extract-alcohol precipitation extract;
The 4th step preparation: the extract of second step and the 3rd step is merged, and then decompression distillation, concentrated making without alcohol concentrate, make pure plant concentrating drinking liquid.
2. a kind of compound concentrating drinking liquid of Novel pure plant with hypoglycemic activity according to claim 1, is characterized in that: described concentrating drinking liquid is preferably made by the raw material of following weight parts:
Balsam pear 30-35 root of kudzu vine 20-25
The bitter buckwheat 10 of mulberry leaf 15-20
Corn stigma 10.
3. a kind of method for making with the compound concentrating drinking liquid of Novel pure plant of hypoglycemic activity described in claim 1 or 2, is characterized in that: comprise pretreatment, prepare extract and preparation:
First step pretreatment: seed, section, oven dry are cleaned, gone to bright balsam pear, makes dried Frutus Momordicae Charantiae;
Second step is prepared ethanol extract: by formulation weight, take dried Frutus Momordicae Charantiae, the root of kudzu vine, mulberry leaf and be ground into 60 object meal, each raw material after pulverizing is mixed, add mixed material weight 12-15 60%-70% ethanol doubly, then in ultrasonic Dynamic Extraction mode, prepare ethanol extract;
The 3rd step is prepared water extract-alcohol precipitation extract: by formulation weight, take bitter buckwheat, corn stigma, add the deionized water of 8 times after pulverizing, heating decocts 1 hour, three times like this, after decoction liquor is merged, with ethanol sedimentation, standing filtration, prepares water extract-alcohol precipitation extract;
The 4th step preparation: the extract of second step and the 3rd step is merged, and then decompression distillation, concentrated making without alcohol concentrate, make pure plant concentrating drinking liquid.
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