CN102483406A - 用于分离胎盘来源微粒的方法和试剂盒以及它们用于诊断胎儿疾病的应用 - Google Patents

用于分离胎盘来源微粒的方法和试剂盒以及它们用于诊断胎儿疾病的应用 Download PDF

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CN102483406A
CN102483406A CN2010800379272A CN201080037927A CN102483406A CN 102483406 A CN102483406 A CN 102483406A CN 2010800379272 A CN2010800379272 A CN 2010800379272A CN 201080037927 A CN201080037927 A CN 201080037927A CN 102483406 A CN102483406 A CN 102483406A
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placenta
microparticles
derived microparticles
antibody
kit
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Chinese (zh)
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阿纳·阿哈龙
本亚明·布伦纳
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RAPAPORT FAMILY INST FOR RES I
FUND FOR MEDICAL RES DEV OF
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RAPAPORT FAMILY INST FOR RES I
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CN2010800379272A 2009-06-24 2010-06-24 用于分离胎盘来源微粒的方法和试剂盒以及它们用于诊断胎儿疾病的应用 Pending CN102483406A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21982409P 2009-06-24 2009-06-24
US61/219,824 2009-06-24
PCT/IL2010/000504 WO2010150259A1 (en) 2009-06-24 2010-06-24 Methods and kits for isolating placental derived microparticles and use of same for diagnosis of fetal disorders

Publications (1)

Publication Number Publication Date
CN102483406A true CN102483406A (zh) 2012-05-30

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CN2010800379272A Pending CN102483406A (zh) 2009-06-24 2010-06-24 用于分离胎盘来源微粒的方法和试剂盒以及它们用于诊断胎儿疾病的应用

Country Status (7)

Country Link
US (1) US20120129183A1 (enExample)
EP (1) EP2446267A1 (enExample)
CN (1) CN102483406A (enExample)
AU (1) AU2010264072A1 (enExample)
CA (1) CA2765779A1 (enExample)
IN (1) IN2012DN00715A (enExample)
WO (1) WO2010150259A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2826111A1 (en) * 2011-01-31 2012-08-09 Esoterix Genetic Laboratories, Llc Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration
US20120196285A1 (en) * 2011-01-31 2012-08-02 Esoterix Genetic Laboratories, Llc Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules
US20160175364A1 (en) * 2013-07-31 2016-06-23 Rappaport Family Institute For Research In The Medical Sciences Trophoblast derived microparticles for treating ischemic tissue and wounds
CN112710851A (zh) * 2020-12-29 2021-04-27 苏州百志生物科技有限公司 一种检测人体液中胎盘生长因子含量的试剂盒

Citations (4)

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CN1043788A (zh) * 1988-12-06 1990-07-11 南澳大利亚·弗林德斯大学 由母体血液中分离胎儿细胞的方法来实现产前诊断
CN1234117A (zh) * 1996-10-21 1999-11-03 应用成像公司 用抗胚胎血红蛋白抗体鉴别胎儿细胞的方法
CN101137760A (zh) * 2005-03-18 2008-03-05 香港中文大学 检测染色体非整倍性的方法
CN101245376A (zh) * 2003-01-17 2008-08-20 香港中文大学 作为妊娠相关病症的诊断标志物的循环mRNA

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NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
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NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
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US20040197832A1 (en) * 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
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AU2003263660A1 (en) * 2003-08-29 2005-03-16 Pantarhei Bioscience B.V. Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
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CN1043788A (zh) * 1988-12-06 1990-07-11 南澳大利亚·弗林德斯大学 由母体血液中分离胎儿细胞的方法来实现产前诊断
CN1234117A (zh) * 1996-10-21 1999-11-03 应用成像公司 用抗胚胎血红蛋白抗体鉴别胎儿细胞的方法
CN101245376A (zh) * 2003-01-17 2008-08-20 香港中文大学 作为妊娠相关病症的诊断标志物的循环mRNA
CN101137760A (zh) * 2005-03-18 2008-03-05 香港中文大学 检测染色体非整倍性的方法

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MARIAN KNIGHT等: "Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies", 《BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY》, vol. 105, no. 6, 30 June 1998 (1998-06-30), XP002608054 *
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AU2010264072A1 (en) 2012-02-16
EP2446267A1 (en) 2012-05-02
WO2010150259A1 (en) 2010-12-29
IN2012DN00715A (enExample) 2015-06-19
US20120129183A1 (en) 2012-05-24
CA2765779A1 (en) 2010-12-29

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Application publication date: 20120530