CN102482221B - 作为katii抑制剂的双环和三环化合物 - Google Patents

作为katii抑制剂的双环和三环化合物 Download PDF

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Publication number
CN102482221B
CN102482221B CN201080036601.8A CN201080036601A CN102482221B CN 102482221 B CN102482221 B CN 102482221B CN 201080036601 A CN201080036601 A CN 201080036601A CN 102482221 B CN102482221 B CN 102482221B
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amino
dihydroquinolin
hydroxy
hydroxyl
compound
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Expired - Fee Related
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Chinese (zh)
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CN102482221A (zh
Inventor
M.M.克拉菲
A.B.杜内伊
甘新民
M.M.海伊沃德
戎锁宝
J.B.塔特尔
P.R.弗霍斯特
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Pfizer Corp SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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CN201080036601.8A 2009-06-18 2010-05-26 作为katii抑制剂的双环和三环化合物 Expired - Fee Related CN102482221B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21814909P 2009-06-18 2009-06-18
US61/218,149 2009-06-18
US33438910P 2010-05-13 2010-05-13
US61/334,389 2010-05-13
PCT/IB2010/052349 WO2010146488A1 (en) 2009-06-18 2010-05-26 Bicyclic and tricyclic compounds as kat ii inhibitors

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Publication Number Publication Date
CN102482221A CN102482221A (zh) 2012-05-30
CN102482221B true CN102482221B (zh) 2014-10-22

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Families Citing this family (14)

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WO2012073143A1 (en) * 2010-12-01 2012-06-07 Pfizer Inc. Kat ii inhibitors
EP2646417A1 (en) * 2010-12-01 2013-10-09 Pfizer Inc Kat ii inhibitors
WO2013005425A1 (ja) * 2011-07-07 2013-01-10 イハラケミカル工業株式会社 ニトロベンゼン化合物の製造方法
CN104364253A (zh) * 2012-06-15 2015-02-18 辉瑞公司 作为kat ii抑制剂的三环化合物
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
DK2746250T3 (en) * 2012-12-21 2018-01-02 Abx Advanced Biochemical Compounds Gmbh Intermediates and Processes for Preparation of 18F-Labeled Amino Acids
JPWO2014174745A1 (ja) * 2013-04-26 2017-02-23 国立大学法人京都大学 Ｅｇ５阻害剤
WO2015163339A1 (ja) 2014-04-23 2015-10-29 田辺三菱製薬株式会社 新規二環性または三環性複素環化合物
CN104592333B (zh) * 2014-07-23 2017-06-27 江西科技师范大学 一种合成5‑羧基‑2’‑脱氧胞苷的方法
EP3372601B1 (en) 2015-10-22 2022-09-21 Mitsubishi Tanabe Pharma Corporation Novel bicyclic heterocyclic compound
GB201613163D0 (en) * 2016-07-29 2016-09-14 Autifony Therapeutics Ltd Novel compounds
EP3588064B1 (en) * 2017-02-23 2022-09-07 IHI Corporation Oh radical detection probe, oh radical measurement device, and oh radical measurement method
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage
CN115872970A (zh) * 2022-12-08 2023-03-31 青岛普力机电工程有限公司 一种从乳酸原料到高纯丙交酯连续生产的方法

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Alvie L.Davis et al.Synthesis and Antibacterial Activities of Some Chloro Analogs of 3-Amino-3,4-dihydro- 1-hydroxycarbostyril.《Journal of Medicinal Chemistry》.1975,第18卷(第7期),第752-755页. *
Synthesis and microbiological properties of 3-amino-3,4-dihydro-1-hydroxycarbostyril;DAVIS,ALVIE L.et al;《JOURNAL OF MEDICINAL CHEMSITRY》;19641231;第7卷(第5期);第632-634页 *
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The Synthesis, Configuration, and Conformation of cis- and trans-3-Amino-3,4-dihydro-l-hydroxy-4- methylcarbostyrils and Other Configurationally Related Compounds;Tommy J. McCord et al;《JOURNAL OF HETEROCYCLIC CHEMISTRY》;19810831;第18卷(第5期);第1035-1039页 *

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WO2010146488A1 (en) 2010-12-23
CR20110625A (es) 2012-02-24
BRPI1011784A2 (pt) 2016-03-22
UY32712A (es) 2011-01-31
CA2763960A1 (en) 2010-12-23
CU20110234A7 (es) 2012-06-21
MA33407B1 (fr) 2012-07-03
HK1166980A1 (en) 2012-11-16
KR20120027480A (ko) 2012-03-21
US8183238B2 (en) 2012-05-22
EP2443092A1 (en) 2012-04-25
ECSP11011539A (es) 2012-01-31
CO6470895A2 (es) 2012-06-29
ZA201108964B (en) 2012-08-29
MX2011013870A (es) 2012-02-01
EA201190287A1 (ru) 2012-06-29
CN102482221A (zh) 2012-05-30
AP2012006071A0 (en) 2012-02-29
AU2010261399B2 (en) 2014-07-17

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