KR101390023B1 - 키누레닌 아미노트랜스퍼라제 ｉｉ 억제제로서 이환식 및 삼환식 화합물 - Google Patents

키누레닌 아미노트랜스퍼라제 ｉｉ 억제제로서 이환식 및 삼환식 화합물 Download PDF

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KR101390023B1
KR101390023B1 KR1020127000437A KR20127000437A KR101390023B1 KR 101390023 B1 KR101390023 B1 KR 101390023B1 KR 1020127000437 A KR1020127000437 A KR 1020127000437A KR 20127000437 A KR20127000437 A KR 20127000437A KR 101390023 B1 KR101390023 B1 KR 101390023B1
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amino
hydroxy
alkyl
dihydroquinolin
dihydro
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KR20120027480A (ko
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미쉘 마리 클래페이
아미 베쓰 도우내이
진민 갠
매튜 메릴 헤이워드
수오바오 롱
재미슨 브리스 터틀
패트릭 로버트 버호스트
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화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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KR1020127000437A 2009-06-18 2010-05-26 키누레닌 아미노트랜스퍼라제 ｉｉ 억제제로서 이환식 및 삼환식 화합물 Expired - Fee Related KR101390023B1 (ko)

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Application Number Priority Date Filing Date Title
US21814909P 2009-06-18 2009-06-18
US61/218,149 2009-06-18
US33438910P 2010-05-13 2010-05-13
US61/334,389 2010-05-13
PCT/IB2010/052349 WO2010146488A1 (en) 2009-06-18 2010-05-26 Bicyclic and tricyclic compounds as kat ii inhibitors

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KR20120027480A KR20120027480A (ko) 2012-03-21
KR101390023B1 true KR101390023B1 (ko) 2014-04-29

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EP (1) EP2443092B1 (enExample)
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CN (1) CN102482221B (enExample)
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Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
WO2012073143A1 (en) * 2010-12-01 2012-06-07 Pfizer Inc. Kat ii inhibitors
EP2646417A1 (en) * 2010-12-01 2013-10-09 Pfizer Inc Kat ii inhibitors
WO2013005425A1 (ja) * 2011-07-07 2013-01-10 イハラケミカル工業株式会社 ニトロベンゼン化合物の製造方法
CN104364253A (zh) * 2012-06-15 2015-02-18 辉瑞公司 作为kat ii抑制剂的三环化合物
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
DK2746250T3 (en) * 2012-12-21 2018-01-02 Abx Advanced Biochemical Compounds Gmbh Intermediates and Processes for Preparation of 18F-Labeled Amino Acids
JPWO2014174745A1 (ja) * 2013-04-26 2017-02-23 国立大学法人京都大学 Ｅｇ５阻害剤
WO2015163339A1 (ja) 2014-04-23 2015-10-29 田辺三菱製薬株式会社 新規二環性または三環性複素環化合物
CN104592333B (zh) * 2014-07-23 2017-06-27 江西科技师范大学 一种合成5‑羧基‑2’‑脱氧胞苷的方法
EP3372601B1 (en) 2015-10-22 2022-09-21 Mitsubishi Tanabe Pharma Corporation Novel bicyclic heterocyclic compound
GB201613163D0 (en) * 2016-07-29 2016-09-14 Autifony Therapeutics Ltd Novel compounds
EP3588064B1 (en) * 2017-02-23 2022-09-07 IHI Corporation Oh radical detection probe, oh radical measurement device, and oh radical measurement method
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage
CN115872970A (zh) * 2022-12-08 2023-03-31 青岛普力机电工程有限公司 一种从乳酸原料到高纯丙交酯连续生产的方法

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WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors

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US5801183A (en) * 1995-01-27 1998-09-01 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists
EP1002535A1 (en) * 1998-10-28 2000-05-24 Hrissanthi Ikonomidou New use of glutamate antagonists for the treatment of cancer
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Patent Citations (2)

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US20050009870A1 (en) 2003-07-11 2005-01-13 Sher Philip M. Tetrahydroquinoline derivatives as cannabinoid receptor modulators
WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors

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IL216603A (en) 2015-07-30
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AU2010261399A1 (en) 2012-01-12
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EP2443092A1 (en) 2012-04-25
ECSP11011539A (es) 2012-01-31
CO6470895A2 (es) 2012-06-29
ZA201108964B (en) 2012-08-29
MX2011013870A (es) 2012-02-01
EA201190287A1 (ru) 2012-06-29
CN102482221A (zh) 2012-05-30
AP2012006071A0 (en) 2012-02-29
AU2010261399B2 (en) 2014-07-17

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