CN102481348A - 双特异性免疫细胞因子停靠-和-加锁(dnl)复合物及其治疗性用途 - Google Patents

双特异性免疫细胞因子停靠-和-加锁(dnl)复合物及其治疗性用途 Download PDF

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CN102481348A
CN102481348A CN2010800385485A CN201080038548A CN102481348A CN 102481348 A CN102481348 A CN 102481348A CN 2010800385485 A CN2010800385485 A CN 2010800385485A CN 201080038548 A CN201080038548 A CN 201080038548A CN 102481348 A CN102481348 A CN 102481348A
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antibody
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cell
people
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C-H·张
D·M·戈登堡
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IBC Pharmaceuticals Inc
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IBC Pharmaceuticals Inc
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Priority claimed from US12/644,146 external-priority patent/US7981398B2/en
Priority claimed from US12/731,781 external-priority patent/US8003111B2/en
Priority claimed from US12/752,649 external-priority patent/US8034352B2/en
Priority claimed from US12/754,140 external-priority patent/US8722047B2/en
Priority claimed from US12/754,740 external-priority patent/US8562988B2/en
Application filed by IBC Pharmaceuticals Inc filed Critical IBC Pharmaceuticals Inc
Priority to CN201510830780.7A priority Critical patent/CN105566498A/zh
Publication of CN102481348A publication Critical patent/CN102481348A/zh
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    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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CN2010800385485A 2009-08-31 2010-08-27 双特异性免疫细胞因子停靠-和-加锁(dnl)复合物及其治疗性用途 Pending CN102481348A (zh)

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CN201510830780.7A CN105566498A (zh) 2009-08-31 2010-08-27 双特异性免疫细胞因子停靠-和-加锁(dnl)复合物及其治疗性用途

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US23842409P 2009-08-31 2009-08-31
US61/238,424 2009-08-31
US12/644,146 2009-12-22
US12/644,146 US7981398B2 (en) 2005-04-06 2009-12-22 PEGylation by the dock and lock (DNL) technique
US12/731,781 US8003111B2 (en) 2005-04-06 2010-03-25 Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo
US12/731,781 2010-03-25
US12/752,649 2010-04-01
US12/752,649 US8034352B2 (en) 2005-04-06 2010-04-01 Tetrameric cytokines with improved biological activity
US12/754,140 US8722047B2 (en) 2005-03-03 2010-04-05 Humanized anti-HLA-DR antibodies
US12/754,140 2010-04-05
US12/754,740 US8562988B2 (en) 2005-10-19 2010-04-06 Strategies for improved cancer vaccines
US12/754,740 2010-04-06
PCT/US2010/046889 WO2011025904A1 (en) 2009-08-31 2010-08-27 Bispecific immunocytokine dock-and-lock (dnl) complexes and therapeutic use thereof

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EP (1) EP2473186A4 (https=)
JP (2) JP5740772B2 (https=)
CN (1) CN102481348A (https=)
AU (1) AU2010286642B2 (https=)
CA (1) CA2772572A1 (https=)
IN (1) IN2012DN01331A (https=)
WO (1) WO2011025904A1 (https=)

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CN105073128A (zh) * 2013-04-03 2015-11-18 Ibc药品公司 用于诱导对疾病的免疫应答的组合疗法
CN108699121A (zh) * 2015-12-23 2018-10-23 格林诺瓦森生物技术股份有限公司 用于抑制补体激活的多肽
CN109071663A (zh) * 2016-02-05 2018-12-21 奥里尼斯生物科学公司 双特异性信号传导剂及其用途
CN109513003A (zh) * 2012-08-14 2019-03-26 Ibc药品公司 用于治疗疾病的t-细胞重定向双特异性抗体
CN114920847A (zh) * 2015-05-13 2022-08-19 埃博灵克斯股份有限公司 基于cd3反应性的t细胞募集多肽

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US20150231241A1 (en) 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
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US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201412659D0 (en) * 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
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WO2017106627A1 (en) 2015-12-17 2017-06-22 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
KR102508650B1 (ko) 2016-04-07 2023-03-13 더 존스 홉킨스 유니버시티 사멸 수용체 작용제로써 췌장암 및 통증을 치료하기 위한 조성물 및 방법
KR102379464B1 (ko) 2016-06-20 2022-03-29 키맵 리미티드 항-pd-l1 항체
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
CN112469661B (zh) * 2018-06-13 2024-04-26 斯克里普斯研究学院 具有新结构组分的纳米粒疫苗
KR20220109436A (ko) * 2019-12-03 2022-08-04 에보텍 인터내셔널 게엠베하 인터페론-결합된 항원 결합 단백질 및 이의 용도
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