CN102471513A - 包含可离子化改性剂的高纯度色谱材料 - Google Patents

包含可离子化改性剂的高纯度色谱材料 Download PDF

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Publication number
CN102471513A
CN102471513A CN2010800348170A CN201080034817A CN102471513A CN 102471513 A CN102471513 A CN 102471513A CN 2010800348170 A CN2010800348170 A CN 2010800348170A CN 201080034817 A CN201080034817 A CN 201080034817A CN 102471513 A CN102471513 A CN 102471513A
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high purity
chromatographic material
purity chromatographic
ionizable
group
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CN2010800348170A
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Chinese (zh)
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K.D.怀恩罕
P.C.伊拉内塔
T.H.沃特
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Waters Technologies Corp
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Waters Technologies Corp
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Priority to CN201510487113.3A priority Critical patent/CN105126792A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3234—Inorganic material layers
    • B01J20/3236—Inorganic material layers containing metal, other than zeolites, e.g. oxides, hydroxides, sulphides or salts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/29—Chiral phases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3289—Coatings involving more than one layer of same or different nature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3291—Characterised by the shape of the carrier, the coating or the obtained coated product
    • B01J20/3293—Coatings on a core, the core being particle or fiber shaped, e.g. encapsulated particles, coated fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/52—Sorbents specially adapted for preparative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN2010800348170A 2009-08-04 2010-08-04 包含可离子化改性剂的高纯度色谱材料 Pending CN102471513A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510487113.3A CN105126792A (zh) 2009-08-04 2010-08-04 包含可离子化改性剂的高纯度色谱材料

Applications Claiming Priority (5)

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US23104509P 2009-08-04 2009-08-04
US61/231045 2009-08-04
US35399910P 2010-06-11 2010-06-11
US61/353999 2010-06-11
PCT/US2010/044390 WO2011017418A1 (en) 2009-08-04 2010-08-04 High purity chromatrographic materials comprising an ionizable modifier

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CN201510487113.3A Pending CN105126792A (zh) 2009-08-04 2010-08-04 包含可离子化改性剂的高纯度色谱材料

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US (1) US10150098B2 (https=)
EP (2) EP2462188A4 (https=)
JP (2) JP6125230B2 (https=)
CN (2) CN102471513A (https=)
IN (1) IN2012DN00363A (https=)
WO (1) WO2011017418A1 (https=)

Cited By (9)

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CN108136275A (zh) * 2015-04-29 2018-06-08 沃特世科技公司 用于超临界流体色谱法的包含离子配对键合相的高纯度色谱材料
CN108176078A (zh) * 2013-06-11 2018-06-19 沃特世科技公司 色谱柱和分离装置及其用途
CN109070050A (zh) * 2016-03-06 2018-12-21 沃特世科技公司 用于色谱分离的具有窄颗粒尺寸分布的包含涂布的芯的表面多孔材料、其制备方法、以及其用途
CN109154604A (zh) * 2016-04-24 2019-01-04 沃特世科技公司 用于对用两亲强碱性部分改性的聚糖进行分析的带电表面反相色谱材料方法
CN109789344A (zh) * 2016-09-30 2019-05-21 得克萨斯州大学系统董事会 用于开管离子色谱的官能化聚烯烃毛细管
CN111107931A (zh) * 2017-09-18 2020-05-05 沃特世科技公司 气相沉积涂覆的流动路径用于改善金属相互作用分析物的色谱法的用途
CN111405934A (zh) * 2017-09-26 2020-07-10 沃特世科技公司 包含用于保留酸性分析物的可电离改性剂的高纯度色谱材料
CN111644164A (zh) * 2012-05-15 2020-09-11 沃特世科技公司 用于分离不饱和分子的色谱材料
CN117222480A (zh) * 2021-04-29 2023-12-12 沃特世科技公司 水解稳定的两性离子色谱材料

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JP6125230B2 (ja) 2009-08-04 2017-05-10 ウオーターズ・テクノロジーズ・コーポレイシヨン イオン性修飾剤を含有する高純度クロマトグラフィー材料
US10159911B2 (en) 2009-08-04 2018-12-25 Waters Technologies Corporation High purity chromatographic materials comprising an ionizable modifier
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WO2012166916A1 (en) 2011-06-03 2012-12-06 Waters Technologies Corporation Method of separation of lipid and biological molecular species using high purity chromatographic materials
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CN103018354A (zh) * 2012-11-26 2013-04-03 沈阳化工大学 一种抗溃疡药物的手性分离分析方法
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JP6821435B2 (ja) * 2014-03-01 2021-01-27 ウオーターズ・テクノロジーズ・コーポレイシヨン 不飽和分子を分離するためのクロマトグラフィー材料
JP2017522579A (ja) * 2014-07-17 2017-08-10 エイゼットワイピー エルエルシーＡｚｙｐ，Ｌｌｃ 液体クロマトグラフィーのための、新たな、超高効率の、表面多孔性粒子（ｓｐｐ）キラル相
CN104492122B (zh) * 2015-01-07 2016-03-30 河北大学 一种无机-有机杂化整体柱的制备方法
JP6443302B2 (ja) * 2015-10-30 2018-12-26 コニカミノルタ株式会社 多孔性樹脂粒子の製造方法
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CN105597715A (zh) * 2016-01-12 2016-05-25 江苏汉邦科技有限公司 一种酰胺嵌入型烷基键合液相色谱填料的制备方法
WO2017203683A1 (ja) * 2016-05-27 2017-11-30 株式会社島津製作所 分離媒体及びその製造方法、分離カラム及びその分離カラムを用いた液体クロマトグラフ
US10618920B2 (en) 2016-06-03 2020-04-14 Agilent Technologies, Inc. Functionalized particles having modified phases
CN108435209B (zh) * 2018-04-08 2020-10-23 南昌大学 一种疏水强酸性炭材料的制备方法
EP3821238B1 (en) * 2018-07-11 2022-08-31 Waters Technologies Corporation Chromatographic system and method for trap-elute mixed mode chromatography
CN109663572B (zh) * 2018-12-19 2020-07-14 南昌大学 氨基和巯基双功能化介孔二氧化硅的制备方法及其在砷去除中的应用
US11994499B2 (en) * 2019-02-27 2024-05-28 Waters Technologies Corporation Coated flow path components for chromatographic effects
JP7346201B2 (ja) * 2019-09-25 2023-09-19 株式会社日立ハイテクサイエンス アミノ酸の検出方法
CN114034805B (zh) * 2021-11-12 2022-10-21 大连润生康泰医学检验实验室有限公司 一种五氟尿嘧啶类药物的代谢动力学分析方法
CN114699799B (zh) * 2022-03-03 2023-06-23 江苏汉德科技有限公司 一种具有离子交换特征的氨基甲酸酯色谱填料的制备方法
CN116099234B (zh) * 2022-11-11 2025-11-18 湖南师范大学 一种低能耗分离乙腈-水的方法
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WO2025173664A1 (ja) * 2024-02-13 2025-08-21 東ソー株式会社 液体クロマトグラフィー用の充填剤及びカラム

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Cited By (16)

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Publication number Priority date Publication date Assignee Title
CN111644164A (zh) * 2012-05-15 2020-09-11 沃特世科技公司 用于分离不饱和分子的色谱材料
CN111644164B (zh) * 2012-05-15 2024-03-08 沃特世科技公司 用于分离不饱和分子的色谱材料
CN108176078A (zh) * 2013-06-11 2018-06-19 沃特世科技公司 色谱柱和分离装置及其用途
CN108136275A (zh) * 2015-04-29 2018-06-08 沃特世科技公司 用于超临界流体色谱法的包含离子配对键合相的高纯度色谱材料
US11642653B2 (en) 2016-03-06 2023-05-09 Waters Technologies Corporation Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material
CN109070053A (zh) * 2016-03-06 2018-12-21 沃特世科技公司 用于色谱分离的具有受控孔隙度的多孔材料；其制备方法；以及其用途
CN109070050A (zh) * 2016-03-06 2018-12-21 沃特世科技公司 用于色谱分离的具有窄颗粒尺寸分布的包含涂布的芯的表面多孔材料、其制备方法、以及其用途
CN109154604A (zh) * 2016-04-24 2019-01-04 沃特世科技公司 用于对用两亲强碱性部分改性的聚糖进行分析的带电表面反相色谱材料方法
CN109789344A (zh) * 2016-09-30 2019-05-21 得克萨斯州大学系统董事会 用于开管离子色谱的官能化聚烯烃毛细管
CN109789344B (zh) * 2016-09-30 2022-04-08 得克萨斯州大学系统董事会 用于开管离子色谱的官能化聚烯烃毛细管
US11400444B2 (en) 2016-09-30 2022-08-02 Board Of Regents, University Of Texas System Functionalized polyolefin capillaries for open tubular ion chromatography
CN111107931A (zh) * 2017-09-18 2020-05-05 沃特世科技公司 气相沉积涂覆的流动路径用于改善金属相互作用分析物的色谱法的用途
CN111107931B (zh) * 2017-09-18 2023-10-10 沃特世科技公司 气相沉积涂覆的流动路径用于改善金属相互作用分析物的色谱法的用途
CN111405934A (zh) * 2017-09-26 2020-07-10 沃特世科技公司 包含用于保留酸性分析物的可电离改性剂的高纯度色谱材料
CN111405934B (zh) * 2017-09-26 2022-04-26 沃特世科技公司 用于离析、分离、纯化或检测酸性极性分子的方法
CN117222480A (zh) * 2021-04-29 2023-12-12 沃特世科技公司 水解稳定的两性离子色谱材料

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JP2013501243A (ja) 2013-01-10
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EP2462188A4 (en) 2016-11-23
EP4129466A1 (en) 2023-02-08
EP2462188A1 (en) 2012-06-13
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