CN102471343A - 作为自分泌运动因子抑制剂的杂环化合物 - Google Patents
作为自分泌运动因子抑制剂的杂环化合物 Download PDFInfo
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- CN102471343A CN102471343A CN2010800318870A CN201080031887A CN102471343A CN 102471343 A CN102471343 A CN 102471343A CN 2010800318870 A CN2010800318870 A CN 2010800318870A CN 201080031887 A CN201080031887 A CN 201080031887A CN 102471343 A CN102471343 A CN 102471343A
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- 229930195724 β-lactose Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009033392.4 | 2009-07-16 | ||
| DE102009033392A DE102009033392A1 (de) | 2009-07-16 | 2009-07-16 | Heterocyclische Verbindungen als Autotaxin-Inhibitoren II |
| PCT/EP2010/003661 WO2011006569A1 (de) | 2009-07-16 | 2010-06-17 | Heterocyclische verbindungen als autotaxin-inhibitoren |
Publications (1)
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| CN102471343A true CN102471343A (zh) | 2012-05-23 |
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| CN2010800318870A Pending CN102471343A (zh) | 2009-07-16 | 2010-06-17 | 作为自分泌运动因子抑制剂的杂环化合物 |
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| EP (1) | EP2454258A1 (https=) |
| JP (1) | JP2012532901A (https=) |
| KR (1) | KR20120090031A (https=) |
| CN (1) | CN102471343A (https=) |
| AR (1) | AR077488A1 (https=) |
| AU (1) | AU2010272922A1 (https=) |
| BR (1) | BR112012000792A2 (https=) |
| CA (1) | CA2768095A1 (https=) |
| DE (1) | DE102009033392A1 (https=) |
| EA (1) | EA201200119A1 (https=) |
| IL (1) | IL217466A0 (https=) |
| MX (1) | MX2012000609A (https=) |
| SG (1) | SG177522A1 (https=) |
| WO (1) | WO2011006569A1 (https=) |
| ZA (1) | ZA201201124B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104684915A (zh) * | 2012-09-25 | 2015-06-03 | 霍夫曼-拉罗奇有限公司 | 新型双环衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| US9630945B2 (en) | 2012-12-19 | 2017-04-25 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) * | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| WO2014152725A1 (en) * | 2013-03-15 | 2014-09-25 | Biogen Idec Ma Inc. | S1p and/or atx modulating agents |
| EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| US9714240B2 (en) | 2013-09-17 | 2017-07-25 | Pharmakea, Inc. | Vinyl autotaxin inhibitor compounds |
| EP3049405A4 (en) | 2013-09-26 | 2017-03-08 | Pharmakea Inc. | Autotaxin inhibitor compounds |
| US9926318B2 (en) | 2013-11-22 | 2018-03-27 | Pharmakea, Inc. | Tetracyclic autotaxin inhibitors |
| EP3071561B1 (en) | 2013-11-22 | 2021-03-24 | Sabre Therapeutics LLC | Autotaxin inhibitor compounds |
| DK3074400T3 (en) | 2013-11-26 | 2018-01-15 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors |
| CA2937616A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| EA032357B1 (ru) * | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| CU24442B1 (es) | 2014-04-04 | 2019-09-04 | X Rx Inc | Derivados de n-(1-(espirocíclico)oxo) amida sustituidos como inhibidores de autotaxina |
| BR112016024473A2 (pt) * | 2014-04-23 | 2018-01-23 | X Rx Inc | composto, composição farmacêutica, e, método para tratamento de uma doença e/ou condição |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CA2986759C (en) | 2015-05-27 | 2025-06-17 | Sabre Therapeutics Llc | AUTOTAXIN INHIBITORS AND THEIR USES |
| AU2016270373A1 (en) | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| AU2016328436B2 (en) | 2015-09-24 | 2020-05-14 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual ATX/CA inhibitors |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| JP6876685B2 (ja) | 2015-09-24 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ａｔｘ阻害剤としての二環式化合物 |
| WO2017050732A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| RU2019132254A (ru) | 2017-03-16 | 2021-04-16 | Ф. Хоффманн-Ля Рош Аг | Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca |
| EP3797617B1 (en) * | 2018-05-21 | 2026-01-21 | ASICS Corporation | Brassiere |
| KR102623218B1 (ko) * | 2018-08-23 | 2024-01-11 | 가천대학교 산학협력단 | 페닐아세트산 유도체 및 이를 유효성분으로 함유하는 자가면역질환 예방 또는 치료용 조성물 |
| US12048678B2 (en) * | 2018-10-02 | 2024-07-30 | Case Western Reserve University | Compounds for treating myelin related disorders |
| CA3243968A1 (en) * | 2022-02-10 | 2023-08-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fused diazepines as insulin-type peptide receptor (INSL3) RXFP2 agonists and their methods of use |
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| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| ME00129B (me) * | 1999-01-19 | 2010-10-10 | Ortho Mcneil Janssen Pharmaceuticals Inc | Triciklicnj benzodiazepini kao antagonisti receptora vazopresina |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| EP1187633A4 (en) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY |
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2009
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2010
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- 2010-06-17 CN CN2010800318870A patent/CN102471343A/zh active Pending
- 2010-06-17 WO PCT/EP2010/003661 patent/WO2011006569A1/de not_active Ceased
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20060074078A1 (en) * | 1999-11-09 | 2006-04-06 | S.C.R.A.S. | Product comprising a transduction inhibitor of heterotrimeric G protein signals combined with another anti-cancer agent for therapeutic use in the treatment of cancer |
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| Title |
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| DAVID E. THURSTON, ET AL.: "Effect of A-Ring Modifications on the DNA-Binding Behavior and Cytotoxicity of Pyrrolo[2,1-c][1,4]benzodiazepines", 《J. MED. CHEM.》 * |
| S.MASSA, ET AL.: "Heterocyclic System. 1. Synthesis of 5,6,6a,7,8,13-Hexahydroquinoxalino[2,1-c][1,4]benzodiazepine", 《JOURNAL OF HETEROCYCLIC CHEMISTRY》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104684915A (zh) * | 2012-09-25 | 2015-06-03 | 霍夫曼-拉罗奇有限公司 | 新型双环衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE102009033392A1 (de) | 2011-01-20 |
| EA201200119A1 (ru) | 2012-07-30 |
| IL217466A0 (en) | 2012-02-29 |
| EP2454258A1 (de) | 2012-05-23 |
| US20120115852A1 (en) | 2012-05-10 |
| WO2011006569A1 (de) | 2011-01-20 |
| MX2012000609A (es) | 2012-01-27 |
| ZA201201124B (en) | 2012-11-28 |
| JP2012532901A (ja) | 2012-12-20 |
| SG177522A1 (en) | 2012-02-28 |
| CA2768095A1 (en) | 2011-01-20 |
| AU2010272922A1 (en) | 2012-03-08 |
| BR112012000792A2 (pt) | 2016-02-23 |
| KR20120090031A (ko) | 2012-08-16 |
| AR077488A1 (es) | 2011-08-31 |
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