CN102459168B - 新指示剂平台 - Google Patents

新指示剂平台 Download PDF

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Publication number
CN102459168B
CN102459168B CN201080030692.4A CN201080030692A CN102459168B CN 102459168 B CN102459168 B CN 102459168B CN 201080030692 A CN201080030692 A CN 201080030692A CN 102459168 B CN102459168 B CN 102459168B
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CN
China
Prior art keywords
indicator
hydrogen
fused
nmr
dmso
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CN201080030692.4A
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English (en)
Chinese (zh)
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CN102459168A (zh
Inventor
U.斯皮兹
L.维克
A.拜尔
C.维穆斯
G.沙伯特
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Biosint SpA
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Biosint SpA
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Publication of CN102459168A publication Critical patent/CN102459168A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080030692.4A 2009-05-07 2010-05-06 新指示剂平台 Active CN102459168B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09159639A EP2256103A1 (en) 2009-05-07 2009-05-07 Novel indicator platform
EP09159639.5 2009-05-07
PCT/EP2010/056212 WO2010128120A1 (en) 2009-05-07 2010-05-06 Novel indicator platform

Publications (2)

Publication Number Publication Date
CN102459168A CN102459168A (zh) 2012-05-16
CN102459168B true CN102459168B (zh) 2014-10-01

Family

ID=41130400

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080030692.4A Active CN102459168B (zh) 2009-05-07 2010-05-06 新指示剂平台

Country Status (6)

Country Link
US (1) US8940909B2 (https=)
EP (2) EP2256103A1 (https=)
JP (1) JP5711218B2 (https=)
CN (1) CN102459168B (https=)
BR (1) BRPI1011044A2 (https=)
WO (1) WO2010128120A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2955592B1 (fr) * 2010-01-27 2016-04-15 Millipore Corp Milieu de culture pour la detection de microorganismes par fluorescence alliant un substrat fluorogene et un fluorophore sensible au ph
BR112013010096B1 (pt) 2010-11-01 2020-03-10 3M Innovative Properties Company Método de detecção de uma atividade biológica
CN103189524B (zh) 2010-11-01 2015-01-28 3M创新有限公司 生物灭菌指示器及其使用方法
EP2479221A1 (en) 2010-11-04 2012-07-25 Biosynth AG Novel applications of indoloindole and indoloquinoline dyes
EP2453021A1 (en) * 2010-11-11 2012-05-16 Biosynth AG Novel indicator compounds
US9435739B2 (en) 2010-11-24 2016-09-06 3M Innovative Properties Company Methods and compositions to detect a biological activity
US20130059320A1 (en) * 2011-08-30 2013-03-07 Lawrence Restaino Selective growth media for campylobacter bacteria and plating media with said growth media
KR101577100B1 (ko) * 2012-11-21 2015-12-11 주식회사 두산 신규 화합물 및 이를 포함하는 유기 전계 발광 소자
FR3000501B1 (fr) 2012-12-28 2015-08-14 Biomerieux Sa Milieu de detection de micro-organismes comprenant au moins un alkyl(thio)glycoside
FR3004195B1 (fr) 2013-04-03 2017-10-06 Biomerieux Sa Utilisation d'au moins un substrat de phosphatase chromogene et/ou fluorogene pour la detection et/ou le denombrement d'enterobacteries dans un echantillon biologique.
GB201319768D0 (en) 2013-11-08 2013-12-25 Glycosynth Ltd Naphthalene derived chromogenic enzyme substrates
FR3015522B1 (fr) * 2013-12-24 2017-02-24 Biomerieux Sa Utilisation d'au moins un substrat de carboxylesterase et/ou de triacylglycerol-lipase pour la detection des bacteries du groupe bacillus cereus
FR3018690B1 (fr) 2014-03-21 2016-04-15 Biomerieux Sa Nouveaux composes antimicrobiens, milieux reactionnels les comprenant, et leurs utilisations
EP3556362A1 (en) * 2018-04-16 2019-10-23 Ecole Polytechnique Federale De Lausanne (Epfl) Sting inhibitors
CN111793069B (zh) * 2019-04-09 2021-05-18 清华大学 一种高效制备含有吲哚结构单元的稠环化合物的方法
US20220267479A1 (en) * 2019-07-25 2022-08-25 North Carolina State University Polyiodide binding compounds and methods of use thereof
WO2021170606A1 (en) 2020-02-26 2021-09-02 Merck Patent Gmbh Device and method for testing differential growth of microorganisms
CN114646636A (zh) * 2022-04-18 2022-06-21 集美大学 一种pH响应薄膜材料及其制备方法和pH指示剂的制备方法
EP4534684A1 (fr) 2023-10-03 2025-04-09 Biomérieux Detection et identification de levures du genre candida, methodes et outils de microbiologie pour ce faire

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1790734A1 (en) * 2005-11-25 2007-05-30 Biosynth AG Microbial assay

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2295953A1 (fr) 1974-12-23 1976-07-23 May & Baker Ltd Nouveaux derives de la pyridazine et compositions herbicides les contenant
US5316906A (en) 1991-08-23 1994-05-31 Molecular Probes, Inc. Enzymatic analysis using substrates that yield fluorescent precipitates
AU3367500A (en) 1999-02-18 2000-09-04 Ortho-Mcneil Pharmaceutical, Inc. Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1790734A1 (en) * 2005-11-25 2007-05-30 Biosynth AG Microbial assay

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates;Donald C. Rogness et.al.;《Tetrahedron Letters》;20090414;第50卷;4003–4008 *
Recent advances in enzyme assays;Jean-Philippe Goddard et.al.;《TRENDS in Biotechnology》;20040430;第22卷(第7期);363-370 *

Also Published As

Publication number Publication date
EP2256103A1 (en) 2010-12-01
US20120058503A1 (en) 2012-03-08
BRPI1011044A2 (pt) 2015-08-25
US8940909B2 (en) 2015-01-27
WO2010128120A1 (en) 2010-11-11
CN102459168A (zh) 2012-05-16
EP2427431B1 (en) 2013-05-01
JP2012526086A (ja) 2012-10-25
EP2427431A1 (en) 2012-03-14
JP5711218B2 (ja) 2015-04-30

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