CN102458684B - 用于液体雾化的微流体设备 - Google Patents

用于液体雾化的微流体设备 Download PDF

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Publication number
CN102458684B
CN102458684B CN201080026065.3A CN201080026065A CN102458684B CN 102458684 B CN102458684 B CN 102458684B CN 201080026065 A CN201080026065 A CN 201080026065A CN 102458684 B CN102458684 B CN 102458684B
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CN
China
Prior art keywords
liquid
working surface
equipment
electrode
saw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080026065.3A
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English (en)
Chinese (zh)
Other versions
CN102458684A (zh
Inventor
詹姆士·弗林德
莱斯利·约
戴维·莫顿
米歇尔·麦金托什
戚爱莎
珍妮·霍
阿努希·拉贾帕克萨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
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Monash University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009902063A external-priority patent/AU2009902063A0/en
Application filed by Monash University filed Critical Monash University
Publication of CN102458684A publication Critical patent/CN102458684A/zh
Application granted granted Critical
Publication of CN102458684B publication Critical patent/CN102458684B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • A61M15/025—Bubble jet droplet ejection devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B05B17/0661—Transducer materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B05B17/0676—Feeding means
    • B05B17/0684—Wicks or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
    • A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Special Spraying Apparatus (AREA)
CN201080026065.3A 2009-05-11 2010-05-11 用于液体雾化的微流体设备 Expired - Fee Related CN102458684B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009902063 2009-05-11
AU2009902063A AU2009902063A0 (en) 2009-05-11 Microfluidic Apparatus for the Atomisation of a Liquid
PCT/AU2010/000548 WO2010129994A1 (en) 2009-05-11 2010-05-11 Microfluidic apparatus for the atomisation of a liquid

Publications (2)

Publication Number Publication Date
CN102458684A CN102458684A (zh) 2012-05-16
CN102458684B true CN102458684B (zh) 2016-02-10

Family

ID=43084541

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080026065.3A Expired - Fee Related CN102458684B (zh) 2009-05-11 2010-05-11 用于液体雾化的微流体设备

Country Status (6)

Country Link
US (1) US8991722B2 (enExample)
EP (1) EP2459319B1 (enExample)
JP (2) JP5860395B2 (enExample)
CN (1) CN102458684B (enExample)
AU (1) AU2010246904B2 (enExample)
WO (1) WO2010129994A1 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129994A1 (en) 2009-05-11 2010-11-18 Monash University Microfluidic apparatus for the atomisation of a liquid
WO2013166542A1 (en) * 2012-05-11 2013-11-14 Monash University Microfluidic apparatus for the atomisation of a liquid using surface acoustic waves
AU2013201383B2 (en) * 2013-03-01 2015-07-02 Royal Melbourne Institute Of Technology Atomisation apparatus using surface acoustic wave generaton
US10404232B2 (en) 2013-10-17 2019-09-03 Royal Melbourne Institute Of Technology Piezoelectric actuation platform
US10052431B2 (en) 2014-06-09 2018-08-21 Ascent Bio-Nano Technologies, Inc. System for manipulation and sorting of particles
GB201420061D0 (en) * 2014-11-11 2014-12-24 Univ Glasgow Nebulisation of liquids
EP3247435B1 (en) * 2015-01-23 2021-03-10 William Tan Ultrasonic vaporizing element
GB2536261A (en) * 2015-03-11 2016-09-14 Linde Ag An ultrasonic piezo nebuliser
GB201509820D0 (en) * 2015-05-06 2015-07-22 Nicoventures Holdings Ltd Aerosol delivery device
US11857992B2 (en) 2015-05-13 2024-01-02 Royal Melbourne Institute Of Technology Acoustic wave microfluidic devices with increased acoustic wave energy utilisation
SG10201509280YA (en) * 2015-11-11 2017-06-29 Singapore Univ Of Tech And Design Microfluidic particle manipulation
GB2548071B (en) * 2015-12-18 2018-05-02 Thermo Fisher Scient Bremen Gmbh Liquid sample introduction system and method, for analytical plasma spectrometer
US11717845B2 (en) 2016-03-30 2023-08-08 Altria Client Services Llc Vaping device and method for aerosol-generation
MY191692A (en) * 2016-03-30 2022-07-07 Philip Morris Products Sa Smoking device and method for aerosol-generation
EP3700684A4 (en) 2017-10-26 2021-08-11 Royal Melbourne Institute Of Technology METHOD AND DEVICE FOR ACOUSTICALLY MEDIATED INTRACELLULAR RELEASE
AU2018382221B2 (en) 2017-12-11 2023-11-09 Royal Melbourne Institute Of Technology Apparatus for addressing wells within a microarray plate
AU2019248020B2 (en) * 2018-04-05 2024-12-19 Royal Melbourne Institute Of Technology Multi surface acoustic nebuliser
ES2741373B2 (es) 2018-08-10 2020-10-01 Inentia Aro Sl Dispositivo electrónico vestible dispensador de sustancias con elementos intercambiables y método de funcionamiento
CN109127180A (zh) * 2018-09-10 2019-01-04 河北工业大学 一种基于c切铌酸锂晶片实时可控溶胶喷射的装置及方法
CN109781810B (zh) * 2019-02-26 2020-04-10 西安交通大学 快速检测重金属离子浓度的阵列声表面波纸基微流控系统
CN110093245B (zh) * 2019-04-28 2021-07-16 武汉大学 一种声表面波液滴激发装置及定点释放肿瘤单细胞的方法
US12156542B2 (en) 2019-06-20 2024-12-03 Shaheen Innovations Holding Limited Personal ultrasonic atomizer device able to control the amount of liquid flow
JP7396824B2 (ja) * 2019-07-02 2023-12-12 株式会社ディスコ 超音波水噴射装置
JP7445015B2 (ja) 2019-12-15 2024-03-06 シャヒーン イノベーションズ ホールディング リミテッド 超音波ミスト吸入器
US12538944B2 (en) 2019-12-15 2026-02-03 Shaheen Innovations Holding Limited Nicotine delivery device with identification arrangement
US11730191B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
PL4031216T3 (pl) 2019-12-15 2025-06-09 Shaheen Innovations Holding Limited Mgiełkowy inhalator ultradźwiękowy
PL3837999T3 (pl) 2019-12-15 2022-10-10 Shaheen Innovations Holding Limited Inhalatory mgiełki
PL3855949T3 (pl) 2019-12-15 2025-08-04 Shaheen Innovations Holding Limited Mgiełkowy inhalator ultradźwiękowy
WO2021123865A1 (en) 2019-12-15 2021-06-24 Shaheen Innovations Holding Limited Ultrasonic mist inhaler
US12121056B2 (en) 2019-12-15 2024-10-22 Shaheen Innovations Holding Limited Hookah device
KR102743597B1 (ko) 2019-12-15 2024-12-18 샤힌 이노베이션즈 홀딩 리미티드 초음파 미스트 흡입장치
US12201144B2 (en) 2019-12-15 2025-01-21 Shaheen Innovations Holding Limited Hookah device
US12233207B2 (en) 2019-12-15 2025-02-25 Shaheen Innovations Holding Limited Mist inhaler devices
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
US11666713B2 (en) 2019-12-15 2023-06-06 Shaheen Innovations Holding Limited Mist inhaler devices
US11589610B2 (en) 2019-12-15 2023-02-28 Shaheen Innovations Holding Limited Nicotine delivery device having a mist generator device and a driver device
WO2021130248A1 (en) * 2019-12-23 2021-07-01 Philip Morris Products S.A. A convergent aerosol-generator
KR20220119436A (ko) * 2019-12-23 2022-08-29 필립모리스 프로덕츠 에스.에이. 다중 공급 요소를 포함하는 에어로졸 발생기
EP4152967A1 (en) 2020-06-01 2023-03-29 Shaheen Innovations Holding Limited An infectious disease screening system
EP4153354A1 (en) 2020-06-01 2023-03-29 Shaheen Innovations Holding Limited An infectious disease screening device
WO2023108316A1 (zh) * 2021-12-13 2023-06-22 中国科学院深圳先进技术研究院 基于声表面波技术的便携式精准可视化雾化递送设备
US20230188901A1 (en) 2021-12-15 2023-06-15 Shaheen Innovations Holding Limited Apparatus for transmitting ultrasonic waves
CN116618224B (zh) * 2023-05-23 2025-12-12 南京林业大学 一种超声雾化变频喷头及其设计方法
CN119608477A (zh) * 2023-09-12 2025-03-14 天津大学 基于高频声波的液体处理装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030173867A1 (en) * 2001-03-20 2003-09-18 Pascal Mauchamp Ultrasonic transducer apparatus
US20080084134A1 (en) * 2004-12-03 2008-04-10 Epson Toyocom Corporation Surface acoustic wave device
JP2008104966A (ja) * 2006-10-26 2008-05-08 Seiko Epson Corp 霧化装置、吸引装置

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049982A (en) 1976-08-18 1977-09-20 The United States Of America As Represented By The Secretary Of The Air Force Elliptical, interdigital transducer
DE2811248C3 (de) 1978-03-15 1981-11-26 Bosch-Siemens Hausgeräte GmbH, 7000 Stuttgart Flüssigkeitszerstäuber
JPS5832618A (ja) 1981-08-19 1983-02-25 Sony Corp 電子線硬化性樹脂
DE69430196T2 (de) 1993-06-29 2002-10-31 Ponwell Enterprises Ltd., Hongkong Spender
US5996903A (en) * 1995-08-07 1999-12-07 Omron Corporation Atomizer and atomizing method utilizing surface acoustic wave
DE19533297A1 (de) * 1995-09-08 1997-03-13 Siemens Ag Dispersiver Unidirektionalwandler für mit akustischen Oberflächenwellen arbeitende Bauelemente
US5831492A (en) * 1995-09-15 1998-11-03 Sawtek Inc. Weighted tapered spudt saw device
US6325475B1 (en) * 1996-09-06 2001-12-04 Microfab Technologies Inc. Devices for presenting airborne materials to the nose
JP2001502666A (ja) 1996-09-12 2001-02-27 ジェネメディシン，インコーポレイテッド 肺遺伝子送達のための組成物および方法
JP2000233158A (ja) 1999-02-12 2000-08-29 Omron Corp 噴霧装置
US6407650B1 (en) * 1999-08-27 2002-06-18 Board Of Regents The University Of Texas System Surface acoustic wave shaping system
US6480076B2 (en) * 2000-12-21 2002-11-12 Trw Inc. Recessed reflector single phase unidirectional transducer
JP2004266632A (ja) 2003-03-03 2004-09-24 Murata Mfg Co Ltd 弾性表面波装置
JP2006087815A (ja) * 2004-09-27 2006-04-06 Canon Inc 噴霧方法および該方法に基づく噴霧装置
CN101137446B (zh) 2005-02-11 2010-06-09 巴特尔纪念研究所 电流体动力气雾剂分配装置及喷射方法
US7954730B2 (en) * 2005-05-02 2011-06-07 Hong Kong Piezo Co. Ltd. Piezoelectric fluid atomizer apparatuses and methods
GB0610090D0 (en) 2006-05-20 2006-06-28 Price Robert Particulate drug compositions and their uses
JP4898566B2 (ja) 2006-07-13 2012-03-14 キヤノン株式会社 薬剤吐出制御方法および薬剤吐出装置
JP2008073570A (ja) * 2006-09-19 2008-04-03 Seiko Epson Corp 霧化器、吸引装置
JP4915567B2 (ja) * 2006-10-26 2012-04-11 パナソニック株式会社 弾性表面波霧化装置
EP1952896B1 (en) 2007-02-01 2012-11-07 EP Systems SA Droplet dispenser
US7891580B2 (en) * 2008-04-30 2011-02-22 S.C. Johnson & Son, Inc. High volume atomizer for common consumer spray products
WO2010129994A1 (en) 2009-05-11 2010-11-18 Monash University Microfluidic apparatus for the atomisation of a liquid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030173867A1 (en) * 2001-03-20 2003-09-18 Pascal Mauchamp Ultrasonic transducer apparatus
US20080084134A1 (en) * 2004-12-03 2008-04-10 Epson Toyocom Corporation Surface acoustic wave device
JP2008104966A (ja) * 2006-10-26 2008-05-08 Seiko Epson Corp 霧化装置、吸引装置

Also Published As

Publication number Publication date
EP2459319B1 (en) 2015-01-21
US8991722B2 (en) 2015-03-31
CN102458684A (zh) 2012-05-16
AU2010246904B2 (en) 2015-08-20
JP2012525944A (ja) 2012-10-25
EP2459319A1 (en) 2012-06-06
US20120187209A1 (en) 2012-07-26
AU2010246904A1 (en) 2011-12-01
WO2010129994A1 (en) 2010-11-18
EP2459319A4 (en) 2013-12-04
JP2016000209A (ja) 2016-01-07
JP5860395B2 (ja) 2016-02-16

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