CN102449151A - 治疗眼部疾病的方法 - Google Patents

Abstract

本发明涉及一种抑制受试者视网膜神经节细胞缺失的组合物和方法，包括向受试者眼睛表面局部无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合包含治疗有效量的至少一种siRNA；所述siRNA下调与视网膜神经节细胞缺失相关的目标基因表达，从而抑制受试者视网膜神经节细胞的缺失。本发明的方法还涉及一种具有结构基序的化学修饰siRNA化合物的用途，所述结构基序下调在哺乳动物眼睛视网膜组织表达的人类基因的表达。

Description

治疗眼部疾病的方法

相关申请

本申请要求于2008年10月22日提交的美国临时专利申请第61/196995号和2008年11月11日提交的美国临时专利申请第61/198931号、以及于2009年2月15日提交的国际专利申请第PCT/IL2009/000179号的优先权，它们的全部内容通过引用并入本文。参考序列列表

说明书中所述的序列(SEQ ID NO：1-33，596)是通过USPTO电子文件系统(EFS)以文本文件形式提交，其标题为“188-PCT2.ST25.txt”，于2009年10月20日生成，文件大小为5952KB，它们的全部内容通过引用并入本文。

技术领域

本发明涉及一种治疗需要的受试者的眼部障碍的无创伤性方法，包括向所需受试者眼睛表面局部施用药物组合物的步骤，所述药物组合物包含与受试者视网膜中视网膜神经节细胞缺失相关的目标基因的治疗型寡核苷酸。此外，本发明涉及一种提高患有眼部疾病、障碍或损伤的受试者视网膜神经节细胞存活的无创伤性方法。

背景技术

向视网膜组织传输核酸化合物，特别是向视网膜神经节细胞是一个很大的给药挑战。迄今为止，滴眼剂被认为主要用于治疗眼前段疾病是有效的，就是因为其已经表明，核酸不通过角膜，且不充足的药物浓度达到眼后段组织(reviewed in del Amo and Urtti，2008.DrugDiscov Today 13(3/4)：135-143；Fattal and Bochot，2006.Adv Drug DelRev 56：1203-1223)。

视网膜神经节细胞(RGC)是一种靠近眼睛视网膜内表面位置的神经细胞。视网膜神经节细胞由感光细胞接收视觉信息，并统一传送视网膜视觉信息至大脑中的几个区域。

此外，同时仍然需要有抑制受试者视网膜神经节细胞缺失的无创伤性方法。各种眼部疾病和障碍是以视网膜神经节细胞(RGC)死亡为特征。因此，仍然需要有一种抑制患有眼部疾病、眼部障碍或眼部损伤或以存在感染眼部疾病、眼部障碍或眼部损伤的风险为特征和/或以视网膜神经节细胞(RGC)变性或死亡介导的受试者视网膜神经节细胞(RGC)缺失的无创伤性方法。

发明概述

本发明涉及一种与视网膜神经节细胞(RGC)变性或死亡相关的眼部疾病、眼部障碍或眼部损伤的无创伤性治疗方法及其使用的组合物。本发明的方法包括向受试者眼睛表面局部施用可用于提高受试者视网膜神经节细胞存活的治疗型寡核苷酸组合物。迄今为止，寡核苷酸已通过系统传输或玻璃体内注射，与有害副作用和患者依从性差相关的方法分别传输到眼部视网膜组织。本发明提供了包含寡核苷酸的局部眼科药物组合物，及其用于下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因表达的无创伤性方法，以挽救视网膜神经节细胞的凋亡并治疗眼部障碍。

因此，一方面，本发明提供一种向患有眼部疾病、眼部障碍或眼部损伤的受试者视网膜组织传输寡核苷酸的无创伤性方法，其中包括向受试者眼睛表面局部施用包含寡核苷酸的眼科组合物。

另一方面，本发明提供一种向患有眼部障碍的受试者视网膜神经节细胞传输寡核苷酸的无创伤性方法，其中包括向受试者眼睛表面局部施用包含寡核苷酸的眼科组合物。

另一方面，本发明提供了一种减弱与患有眼部疾病、眼部障碍或眼部损伤的受试者视网膜的视网膜神经节细胞缺失相关的目标基因表达的方法，其中包括向受试者眼睛表面局部(无创伤性)施用药物组合物，所述药物组合物包含目标基因的mRNA产物的至少一种寡核苷酸，以一定用量经过一段时间能有效减弱受试者视网膜基因的表达。

另一方面，本发明提供一种治疗受试者患有视网膜神经节细胞缺失或视网膜神经节细胞损伤的方法，并提供神经保护剂给患有或者存在感染眼部疾病、眼部障碍或眼部损伤风险的受试者。该方法包括向受试者眼睛表面局部施用眼科药物组合物，所述眼科药物组合物包括受试者视网膜目标基因靶向的至少一种寡核苷酸，以一定用量经过一段时间能有效抑制视网膜神经节细胞缺失或视网膜神经节细胞损伤。

在不同实施例中，眼科药物组合物被配制为霜、泡沫、膏、软膏、乳剂、包括滴眼剂、凝胶、喷雾、悬浮液、微乳液、微球、微囊剂、纳米球、纳米粒子、脂质囊泡、脂质体、聚合物囊泡、眼罩或隐形眼镜的液体溶液。在一些实施例中，药物组合物被配制为滴眼剂。在优选实施例中，向眼睛施用眼科组合物，例如，是通过滴眼剂滴注或通过施用薄雾。

在某些实施例中，至少一种目标眼部mRNA基因是选自任一SEQID NO：1-58所述mRNA多核苷酸。在某些实施例中，至少一种目标基因是选自被转录为任一SEQ ID NO：1-58所示mRNA多核苷酸的基因。

在一些实施例中，至少一种寡核苷酸是选自化学修饰的siRNA、未修饰的RNA、反义、核酶、miRNA和shRNA。在优选实施例中，至少一种寡核苷酸是化学修饰的siRNA。在一些实施例中，siRNA正义和反义寡核苷酸均是选自显示于表B1-B36中的正义和相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。

在一些实施例中，眼部障碍、疾病或损伤是选自青光眼、干眼症、糖尿病视网膜病变(DR)、糖尿病性黄斑水肿(DME)或老年性黄斑变性(AMD)。在其他实施例中，眼部障碍、疾病或损伤是视神经炎、视网膜中央静脉阻塞、视网膜分枝静脉阻塞(BRVO)。在进一步实施例中，眼部障碍、疾病或损伤是色素性视网膜炎(RP)、缺血性视神经病变或视神经损伤。在进一步的实施例中，眼部障碍、疾病或损伤是早产儿视网膜神经节的视网膜病变(ROP)、黄斑变性、遗传性视神经病变、代谢性视神经病变，以及由于毒剂或药物不良反应或维生素缺乏症引起的视神经病变。在另一个实施例中，该障碍是与肿瘤疾病相关的视力丧失。

在不同实施例中，至少一种siRNA化合物被传输到受试者眼睛作为液体溶液，其中包括滴眼剂。在不同实施例中，本发明提供了一种减弱与患有眼部疾病、障碍或损伤的受试者的视网膜神经节细胞缺失相关的目标眼部基因表达的方法，其中包括向受试者眼睛表面局部施用以滴眼剂为配方的眼科药物组合物。

在不同实施例中，目标眼部mRNA的表达在患有眼部疾病、障碍或损伤的受试者视网膜眼部细胞中减弱。在不同实施例中，眼部细胞包括但不仅限于泪腺腺泡细胞、泪腺导管细胞、视网膜神经节细胞(RGC)、视网膜色素上皮(RPE)细胞、脉络膜细胞、角膜细胞、睫状突细胞或小梁网细胞或其组合。

本发明提供了一种抑制受试者视网膜神经节细胞缺失的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至少一种siRNA的治疗有效量，所述siRNA下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因表达，从而抑制视网膜神经节细胞的丧失。在某些实施例中，两种或多种目标基因根据本发明方法被下调。至少一种与受试者视网膜的视网膜神经节细胞缺失相关的目标基因(眼部mRNA)的减弱表达赋予眼部神经保护特性。在不同实施例中，至少一种眼部目标基因是选自表A1至A4的列表，如SEQ ID NO：1-58所述。

在一个实施例中，所述眼部障碍是青光眼。因此，本发明提供了一种抑制患有青光眼受试者的视网膜神经节细胞缺失的方法，其中包括局部(无创伤性)向受试者眼睛表面施用眼科组合物，所述眼科组合物包括包括至少一种siRNA的治疗有效量，所述siRNA下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因表达，从而抑制受试者眼睛视网膜神经节细胞的缺失。在优选实施例中，siRNA是化学修饰的。在一些实施例中，化学修饰的siRNA减弱基因在受试者眼睛视网膜(目标眼部mRNA)的表达。在其他实施例中，化学修饰的siRNA减弱目标mRNA在受试者眼睛视神经中的表达。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达是青光眼的有效治疗方法。在某些实施例中，至少一种目标基因是选自表A1，如SEQ ID NO：1-35所述。在某些优选实施例中，该目标基因是选自CASP2(SEQ ID NO：1-2)、ASPP1(SEQ ID NO：4)、TP53BP2(SEQ ID NO：6-7)、BNIP3(SEQ ID NO：12)，RTP801L(SEQ ID NO：14)、ACHE(SEQ ID NO：19-20)、ADRB1(SEQ ID NO：21)和CAPNS1(SEQ ID NO：28-29)。在不同实施例中，该基因如SEQ IDNO：1-2所述。在一些实施例中，siRNA正义和反义链均是选自SEQ IDNO：8515-9516所述的寡核苷酸序列对。

在另一个实施例中，所述眼部障碍是干眼症。因此，本发明提供了一种抑制患有干眼症受试者的视网膜神经节细胞缺失的方法，所述方法包括局部(无创伤性)向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至少一种siRNA的治疗有效量，所述siRNA下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因(目标眼部mRNA)表达，从而抑制受试者眼睛视网膜神经节细胞的缺失。在优选实施例中，siRNA是化学修饰的。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达是干眼症的有效治疗方法。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达对减轻干眼症症状有效。在某些实施例中，至少一种目标基因(目标眼部mRNA)在受试者眼睛视网膜神经节细胞中表达。在某些实施例中，至少一种目标基因(目标眼部mRNA)在受试者眼睛泪腺中表达。在某些实施例中，至少一种目标基因是选自表A2，如任一SEQ ID NO：5(p53)、SEQ ID NO：8-10(LRDD)、SEQ ID NO：26-27(SHC1)和SEQ ID NO：30-44(FAS和FAS配位体)所述。在一些实施例中，该目标基因是选自FAS、FAS配位体(FASL)、p53、LRDD、PARP1、AIF(凋亡诱导因子)、NOS、NOS2A、XIAP和SHC1-SHC。在某些优选实施例中，目标基因如任一SEQ ID NO：36-SEQ ID NO：43或SEQ ID NO：44所述。在一些实施例中，siRNA的正义和反义链均是选自SEQ ID NO：13，225-15，224所述的寡核苷酸序列对。

在另一个实施例中，所述眼部障碍是AMD、DR或DME。因此，本发明提供了一种抑制患有AMD、DR或DME的受试者的视网膜神经节细胞缺失的方法。所述方法包括局部(无创伤性)向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至少一种siRNA的治疗有效量，所述siRNA下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因(目标眼部mRNA)表达，从而抑制受试者眼睛视网膜神经节细胞的缺失。在优选实施例中，siRNA是化学修饰的。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达是AMD、DR或DME的有效治疗方法。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达对减轻AMD、DR或DME症状有效。在某些实施例中，至少一种siRNA的施用减弱至少一种目标基因(靶mRNA)在受试者眼睛视网膜神经节细胞中表达。在某些实施例中，至少一种siRNA的施用减弱至少一种目标基因(目标眼部mRNA)在受试者眼睛脉络膜中的表达。在某些实施例中，至少一种目标基因列于表A3，如任一SEQ ID NO：1-2、3、5、6-7、8-10、12、13、24-25、26-27、30-35、45-53所述。在某些实施例中，siRNA靶向CTSD、RTP801和BNIP3。在某些实施例中，该障碍是DR。siRNA靶向SEQ ID NO：48-53所述的mRNA。在一些实施例中，siRNA的正义和反义链均是选自SEQ IDNO：24575-29594所述的任一序列。在某些优选实施例中，该障碍是AMD，siRNA靶向SEQ ID NO：3所述的基因，siRNA的正义和反义链均是选自SEQ ID NO：11285-12224所述的任一序列。在一些实施例中，siRNA的正义和反义链均是选自SEQ ID NO：24575-29594所述的寡核苷酸序列对。

在一个进一步的实施例中，所述眼部障碍是视网膜色素变性(RP)。因此，本发明提供了一种抑制患有RP的受试者的视网膜神经节细胞缺失的方法。所述方法包括局部(无创伤性)向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至少一种siRNA的治疗有效量，所述siRNA下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因(目标眼部mRNA)表达，从而抑制受试者眼睛视网膜神经节细胞的缺失。在优选实施例中，siRNA是化学修饰的。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达是RP的有效治疗方法。在某些实施例中，减弱与受试者视网膜神经节细胞缺失相关的至少一种目标基因的表达对减轻RP症状有效。在某些实施例中，至少一种目标眼部mRNA是选自表A4所列基因的产物，其被转录为任一SEQ ID NO：3、14、26-35、54-57所述的mRNA。在一些实施例中，目标眼部mRNA是选自由CASP1、CASP3、CASP12、RTP801、RTP801L、CAPNS1、PARP1、AIF、NOS1、NOS2、XIAP和SHC1-SHC组成的组的基因产物。在某些优选实施例中，siRNA靶向SEQ ID NO：56-57所述的基因。

另一方面，本发明是以一种拯救受试者视网膜神经节细胞的细胞凋亡的方法为特征，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括受试者视网膜的目标基因的治疗有效量的至少一种siRNA，从而拯救受试者视网膜神经节细胞的细胞凋亡。在优选实施例中，至少一种siRNA是化学修饰的。在一些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸，如SEQ ID NO：59-33，596所述。

另一方面，本发明提供一种提高呈现视神经病变体征或症状的受试者视网膜神经节细胞存活的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至少一种siRNA的治疗有效量，所述siRNA下调与受试者视网膜的视网膜神经节细胞缺失相关的目标基因表达，从而提高受试者视网膜神经节细胞的存活。在优选实施例中，至少一种siRNA是化学修饰的。在某些实施例中，视神经病变的体征或症状是由细胞凋亡介导的。在一些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自正义及其相应的反义寡核苷酸，如SEQ IDNO：59-33，596所述。

另一方面，本发明涉及一种预防、治疗或减轻与受试者视网膜神经节细胞死亡相关的眼部疾病的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合包括受试者视网膜目标基因的治疗有效量的至少一种siRNA，从而预防、治疗或减轻与受试者视网膜神经节细胞死亡相关的眼部疾病。在优选实施例中，至少一种siRNA是化学修饰的。在某些实施例中，该目标基因如任一SEQ IDNO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸，如SEQ IDNO：59-33，596所述。

另一方面，本发明提供了一种治疗或预防受试者视网膜神经节细胞死亡的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括：(a)受试者视网膜目标基因的治疗有效量的至少一种siRNA，和(b)药学上可接受的赋形剂或载体或其混合物，从而治疗或预防受试者视网膜神经节细胞死亡。在优选实施例中，至少一种siRNA是化学修饰的。在一些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自正义及其相应的反义寡核苷酸，如SEQ IDNO：59-33，596所述。

另一方面，本发明涉及一种预防由受试者眼睛中高眼压介导的视网膜神经节细胞死亡的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合包括受试者视网膜目标基因的治疗有效量的至少一种siRNA，从而预防受试者视网膜神经节细胞死亡。在优选实施例中，至少一种siRNA是化学修饰的。在一个特定实施例中，根据这一方法该受试者是患有青光眼。在一些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自正义及其相应的反义寡核苷酸，如SEQ IDNO：59-33，596所述。

本发明还提供了一种延迟、预防或拯救患有高IOP受试者的视网膜细胞死亡的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括与受试者视网膜的RGC死亡相关的目标基因的治疗有效量的至少一种siRNA，从而延迟、预防或拯救视网膜细胞的损伤或死亡，其中眼内压(IOP)仍然大幅度提升。在优选实施例中，至少一种siRNA是化学修饰的。在一个特定实施例中，根据这一方法该受试者是患有青光眼。在一些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自SEQ ID NO：59-33，596所述的正义及其相应的反义寡核苷酸。

本发明还提供一种治疗患有视网膜神经节细胞缺失或视网膜神经节细胞损伤受试者的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至受试者视网膜的目标基因的治疗有效量的至少一种siRNA，从而治疗受试者或降低受试者视网膜细胞的死亡。在优选实施例中，至少一种siRNA是化学修饰的。在一些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自SEQ ID NO：59-33，596所述的正义及其相应的反义寡核苷酸。

本发明还提供了一种降低视网膜神经节细胞缺失的方法，并提供神经保护剂给所需要的受试者，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至受试者视网膜的目标基因的治疗有效量的至少一种siRNA，从而降低网膜神经节细胞缺失，并提供神经保护剂给受试者。在优选实施例中，至少一种siRNA是化学修饰的。在某些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。

本发明还提供一种预防与受试者视网膜神经节细胞缺失相关的视野丧失的方法，其中包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包括至受试者视网膜的目标基因的治疗有效量的至少一种siRNA，从而预防受试者的视野丧失。在优选实施例中，至少一种siRNA是化学修饰的。在某些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。

另一方面，本发明提供了一种无创伤治疗与受试者视网膜神经节细胞缺失相关的眼部疾病的眼科组合物，其中包括：(a)受试者视网膜目标基因的治疗有效量的至少一种siRNA，和(b)药学上可接受的赋形剂或载体或其混合物。在优选实施例中，至少一种siRNA是化学修饰的。在某些实施例中，该目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。

另一方面，本发明提供了一种无创伤治疗与视觉系统组织的病理性异常/变化有关的眼部疾病的局部眼科药物组合物，其中包括：(a)受试者视网膜目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如任一SEQ ID NO：1-58所述，和(b)药学上可接受的赋形剂或载体或其混合物。在优选实施例中，至少一种siRNA是化学修饰的。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。

根据另一方面，本发明涉及一种用于治疗与视网膜神经节细胞死亡相关的眼部疾病的眼科药物组合物，其中包括：(a)受试者视网膜目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如任一SEQ ID NO：1-58所述，和(b)药学上可接受的赋形剂或载体或其混合物。在优选实施例中，至少一种siRNA是化学修饰的。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。

在不同实施例中，所述眼部疾病是选自包括青光眼、干眼症、糖尿病视网膜病变(DR)、糖尿病性黄斑水肿(DME)、老年性黄斑变性(AMD)、视神经炎、视网膜中央静脉阻塞、视网膜分枝静脉阻塞、缺血性视神经病变、视神经损伤、早产儿视网膜病变(ROP)、色素性视网膜炎(RP)、视网膜神经节细胞变性，黄斑变性、遗传性视神经病变、代谢性视神经病变，以及由于毒剂或药物不良反应或维生素缺乏症引起的视神经病变；所述组合物被配制为霜、泡沫、膏、软膏、乳剂、液体溶液、滴眼剂、凝胶、喷雾、悬浮液、微乳液、微球、微囊剂、纳米球、纳米粒子、脂质囊泡、脂质体、聚合物囊泡、眼罩或生物插入物。在优选实施例中，所述组合物被配制为滴眼剂。

另一方面，本发明涉及一种包装的药物制剂，其中包括：(a)容器内根据本发明的药物组合物(b)所述组合物用于治疗眼部疾病的说明书。在不同实施例中，根据本发明的药物组合物包括患有眼部疾病的受试者视网膜目标基因的治疗有效量的至少一种siRNA。在优选实施中，至少一种siRNA是化学修饰的。在一些实施例中，目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA的正义和反义寡核苷酸均是选自显示于表B1-B36的正义及其相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。在一特定实施例中，根据本发明的一方面，所述药物组合物是用于无创伤性治疗与受试者视网膜神经节细胞缺失相关的眼部疾病。在另一特定实施例中，根据本发明的一方面，所述药物组合物是用于无创伤性治疗与视觉系统组织病理异常/变化相关的眼部疾病。在另一特定实施例中，根据本发明的一方面，所述药物组合物是用于无创伤性治疗患有与视网膜神经节细胞死亡相关的眼部疾病的受试者。

根据另一方面，本发明涉及根据本发明在药剂加工中提高受试者视网膜神经节细胞存活的药物组合物的用途。在不同实施例中，根据本发明的药物组合物包括患有眼部疾病的受试者视网膜目标基因的治疗有效量的至少一种siRNA。在优选实施中，至少一种siRNA是化学修饰的。在一些实施例中，目标基因如任一SEQ ID NO：1-58所述。在不同实施例中，siRNA正义和反义寡核苷酸均是选自显示于表B1-B36的正义和相应的反义寡核苷酸对，如SEQ ID NO：59-33，596所述。在一特定实施例中，根据本发明的一方面，所述药物组合物是用于无创伤性治疗与受试者视网膜神经节细胞缺失相关的眼部疾病。在另一特定实施例中，根据本发明的一方面，所述药物组合物是用于无创伤性治疗与视觉系统组织病理异常/变化相关的眼部疾病。在另一特定实施例中，根据本发明的一方面，所述药物组合物是用于无创伤性治疗受试者患有与视网膜神经节细胞死亡相关的眼部疾病。

在一些实施例中，所述组合物包括增粘剂。增粘剂是选自(例如)亲水聚合物，其中包括纤维素和纤维素衍生物，如甲基纤维素和甲基纤维素衍生物。这些药剂包括甲基纤维素、羟乙基纤维素、羟丙基纤维素、羟丙甲基纤维素和羧甲基纤维素及其衍生物、组合和盐类。在一些实施例中，增粘剂是甲基纤维素。在某些实施例中，所提供的增粘剂浓度为约0.01％至约4％，在其他实施例中，所提供的增粘剂浓度为约0.1％至约3％，或约0.5％至约2％。

在一些实施例中，所述组合物包括提供渗透压平衡或者表面活性剂的药剂。这些药剂包括丙三醇、乙二醇、聚乙二醇(PEG)、丙二醇、山梨醇、甘露醇、单糖、双糖和低聚糖。

本发明还提供一种治疗所需受试者青光眼的方法，其中包括局部(无创伤性)地向受试者眼睛表面施用受试者眼睛目标基因的治疗有效量的至少一种siRNA，以一定量有效治疗青光眼。在某些优选实施例中，siRNA是化学修饰的。在某些实施例中，至少一种siRNA抑制至少一种基因在受试者眼睛视网膜中的表达。在某些实施例中，至少一种基因抑制赋予眼部神经保护特性。在某些实施例中，至少一种基因是选自表A1的列表，其被转录为SEQ ID NO：1-35所述的mRNA。在某些优选实施例中，该基因是选自CASP2(SEQ ID NO：1-2)、ASPP1(SEQ ID NO：4)、TP53BP2(SEQ ID NO：6-7)、BNIP3(SEQ ID NO：12)、RTP801L(SEQ ID NO：14)、ACHE(SEQ ID NO：19-20)、ADRB1(SEQ ID NO：21)和CAPNS1(SEQ ID NO：28-29)。在不同实施例中，该基因如SEQ ID NO：1-2所述。在一些实施例中，siRNA的正义和反义链是选自SEQ ID NO：8515-9516所述的任一序列。

本发明还提供了一种治疗所需受试者干眼症的方法，其中包括局部(无创伤性)地向受试者眼睛表面施用至少一种siRNA的治疗有效量，所述siRNA抑制至少一种基因在受试者眼睛中的表达，其以一定量有效降低干眼症症状。在某些优选实施例中，siRNA是化学修饰的。在某些实施例中，至少一种基因在受试者泪腺中表达。在某些实施例中，至少一种基因是选自表A2，如任一SEQ ID NO：5、SEQ IDNO：8-10、SEQ ID NO：26-27和SEQ ID NO：30-44所述。在一些实施例中，所述基因是选自FAS、FAS配位体(FASL)、p53、LRDD、PARP1、AIF(凋亡诱导因子)、NOS1、NOS2A、XIAP和SHC1-SHC。在某些优选实施例中，所述基因被转录成任一SEQ ID NO：36-SEQID NO：44所述的mRNA。在一些实施例中，siRNA的正义和反义链均是选自表6-17中SEQ ID NO：13、225-15、224所述的任一序列。

本发明还提供了一种治疗所需受试者AMD、DR或DME的方法，其中包括局部(无创伤性)地向受试者眼睛表面施用至少一种siRNA的治疗有效量，所述siRNA抑制至少一种基因在受试者眼睛中的表达，其以一定量有效降低AMD、DR或DME症状。在某些优选实施例中，siRNA是化学修饰的。在某些实施例中，至少一种siRNA抑制至少一种基因在受试者眼睛脉络膜中的表达。在某些实施例中，至少一种目标眼部mRNA列于表A3，如任一SEQ ID NO：1-2、3、5、6-7、8-10、12、13、24-25、26-27、30-35、45-53所述。在某些优选实施例中，siRNA靶向CTSD、RTP801和BNIP3。在某些优选实施例中，所述眼部障碍是DR，siRNA靶向SEQ ID NO：48-53所述的mRNA。

在一个进一步的实施例中，所述眼部障碍是视网膜色素变性(RP)。因此，本发明提供了一种减弱目标眼部mRNA在患有RP的受试者眼睛中表达的方法。所述方法包括局部(无创伤性)地向受试者眼睛表面施用受试者眼睛目标基因的治疗有效量的至少一种siRNA。在某些优选实施例中，siRNA是化学修饰的。在某些实施例中，至少一种目标基因(目标眼部mRNA)的减弱表达是有效治疗RP的方法。在某些实施例中，至少一种目标眼部mRNA的减弱表达对减轻RP症状有效。在某些实施例中，至少一种目标眼部mRNA是选自表A4所列基因的基因产物，其被转录为任一SEQ ID NO：3、14、26-35、54-57所述的mRNA。在一些实施例中，目标眼部mRNA是选自由CASP1、CASP3、CASP12、RTP801、RTP801L、CAPNS1、PARP1、AIF、NOS1、NOS2、XIAP和SHC1-SHC组成的组的基因产物。在某些优选实施例中，siRNA靶向SEQ ID NO：56-57所述的mRNA。

在不同实施例中，至少一种siRNA是化学修饰的。在不同实施例中，至少一种siRNA包括足够数量的具有与目标mRNA中的核苷酸序列具有充分同源性的连续核苷酸序列，以与mRNA杂交，并减弱mRNA在受试者眼睛中的表达。

在不同实施例中，至少一种siRNA包括包括足够数量的具有与基因中的核苷酸序列具有充分同源性的连续核苷酸序列，以与该基因杂交，并降低或抑制基因在受试者眼睛中的表达。

附图简要说明

图1A-1B：表示施用滴眼剂后注入小鼠视网膜的Cy3标记DDIT4siRNA的典型图像。

图2A-2C：表示施用滴眼剂后注入小鼠泪腺导管及腺泡细胞的Cy3标记DDIT4siRNA的典型图像。

图3A-3C：表示施用滴眼剂1-4小时后小鼠脉络膜的Cy3-siRNA累积随时间的变化。

图4：表示向眼睛施用滴眼剂1小时后传输到小梁网和睫状体的Cy3-siRNA。

图5A-5B：表示施用p53基因靶向QM5-siRNA的滴眼剂1小时后的视网膜共聚焦显微镜图像(倍数X60)。视网膜的siRNA(视网膜色素上皮细胞，视网膜神经节细胞)通过Cy3荧光显示。

图6A-6B：表示注入小鼠视网膜的Cy3标记DDIT4siRNA的典型图像。图6B表示施用滴眼剂1小时后DDIT4_1Cy3-siRNA的累积。感光细胞的脉络膜、外核层、RPE和外节层显示了Cy3染色。

图7显示了施用滴眼剂1小时后RGC细胞通过使用Dy-649/C6染色的DDIT4_1Dy-649/C6-siRNA累积。

图8A-8C表示对照siRNA FITC-CNL_1RD/CNL_1FD和不规则的3′cy3-CNL_1RGC通过不同染色方法传输到视网膜组织。

图9A-9B表示Casp2的不同结构传输到小鼠视网膜组织。

图10A-10B表示TGASEII-FAM和HNOEL-FAM的传输。

图11表示PBS中作为阳性对照组的p53靶向siRNA的视网膜传输。

图12A-12B表示正常动物或施用不含有siRNA的ED后视网膜中无荧光信号。

图13A-13D提供了显示视网膜中p53抑制的实验结果。图13A-13B显示了测量p53蛋白水平的标准曲线。图13C-13D显示了通过滴眼剂实现的视网膜p53抑制。

发明详述

本发明提供了局部寡核苷酸组合物及其用于治疗各种眼部疾病及障碍的无创伤性方法。特别地，本发明提供了与患有该疾病或障碍的受试者眼睛基因表达相关的不同眼部疾病及障碍的治疗方法。

本发明部分是基于siRNA组合物靶向某些眼部组织和细胞类型的局部无创伤性给药的意外发现，并当局部传输至眼睛表面时在那些组织和细胞中很活跃。考虑到已知siRNA的传输障碍以及提供无创伤性方法作为玻璃体或全身传输的现实选择，这一发现是令人惊讶的。

对于有效沉默目标基因的mRNA的siRNA分子，所述siRNA需要三个层次的目标：目标组织、目标细胞的类型和目标亚细胞室。现在本发明公开了治疗眼部疾病和障碍的无创伤性方法。

本发明通常涉及下调基因在眼部细胞中表达的化合物，特别涉及新的小干扰RNA(siRNA)，以及这些新的siRNAs在治疗受试者患有与眼部组织和细胞中基因表达相关的疾病的用途。

对减弱眼部目标mRNA表达的方法及治疗眼部障碍的方法在此进行了详细谈论，任何所述分子和/或组合物可有益地用于治疗患有所述疾病的受试者。

本发明的siRNA具有可能增加活性、增加稳定性或减少毒性的结构和修饰；对本发明siRNAs的新修饰可以有益地应用到用于防止或减弱目标基因表达的双链RNA序列中，特别是此处讨论的目标基因。

每一个指示目标基因的非限制性实例，已详列于表A1-A4，见下文。

表A1：治疗青光眼的目标基因

表A2：治疗干眼症的目标基因

表A3：治疗DR、DME、AMD的目标基因

表A4：治疗视网膜色素变性的目标基因的实例(RP)

“变体”或“v”指的是转录变体。

表A1-A4提供了本发明涉及寡核苷酸抑制剂(“v”指的是转录变量)的人类mRNA多核苷酸的实例的gi(基因信息标识符)和序列号。

表A1、A2、A3和A4中的基因抑制剂分别用于治疗，尤其是青光眼、干眼症、糖尿病性视网膜病变(DR)、糖尿病性黄斑水肿(DME)、老年性黄斑变性(AMD)和视网膜色素变性(RP)。

定义

为了方便在本说明书中使用某些术语，此处实例和权利要求对其进行了描述。

应当指出的是，此处所使用的单数形式“a”、“an”和“the”包括复数形式，除非另有明确规定的内容。

本发明各方面或实施例根据马库什分组或其他替代分组，从而本领域的普通技术人员将会意识到本发明也能根据任何独立成员或该组成员的子群进行描述。

“抑制剂”是一种能在一定程度上降低基因表达或该基因产物的活跃性以达到所需生物或生理效应的化合物。此处所用的术语“抑制剂”指的是一种或多种寡核苷酸酶抑制剂，包括siRNA、反义、shRNA、miRNA和核酶。抑制可能也被称为mRNA的减弱表达、下调或RNA干扰(RNAi)、沉默。此处披露的抑制剂是化学修饰的siRNA化合物，其包括修饰，如糖基和/或碱基和/或寡核苷酸结构中核苷酸之间连接的变化。

此处所用的术语“抑制”或“减弱”，指的是在一定程度上降低基因、变体或其产物表达或这种基因产物的活性，以达到所需的生物或生理效应。抑制可能是完全或部分的。例如，CASP2基因的“抑制”指的是基因表达(转录或翻译)或任何表A1或A3所公开的一种或多种变体或SNP(单核苷酸多态性)或其它变体多肽活性的抑制。

“眼部组织”指的是与眼部结构有关的任何组织，旨在以非限制性方式包含巩膜、角膜、脉络膜、视网膜、泪腺和视神经。

“眼部细胞”指的是与眼部结构和泪器相关的任何细胞，旨在以非限制性方式包含视网膜神经节细胞、视网膜色素上皮细胞、角膜细胞、结膜、前房、虹膜、睫状突、视网膜、脉络膜和脉络膜细胞、小梁网等。例如，小梁网包括内葡萄膜网、角巩膜网、小梁和近小管组织。泪腺包括泪腺本身、低级和高级泪点、低级和高级泪小管、泪囊等。

此处所使用的术语“多核苷酸”和“核酸”可以互换使用，并指的是包括脱氧核糖核酸(DNA)和核糖核酸(RNA)的核苷酸序列。该术语也应理解为包括由核苷酸类似物制成的RNA或DNA的等同物或类似物。在本申请中，mRNA序列被描述表示相应的基因。术语“mRNA多核苷酸序列”和mRNA可以互换使用。

“寡核苷酸”、“寡核糖核苷酸”或“低聚物“指的是具有约2至50个核苷酸的脱氧核苷酸或核糖核苷酸序列。该序列的每个DNA或RNA可以是独立天然或合成的和/或修饰或未修饰的。修饰包括糖基、碱基和/或寡核苷酸结构中核苷酸之间连接的变化。本发明的化合物包括由脱氧核苷酸、核糖核苷酸、修饰的脱氧核苷酸、修饰的核糖核苷酸及其组合组成的分子。

本发明提供了一种抑制体内目标基因表达的方法和组合物。一般情况下，该方法包括局部施用寡核糖核苷酸，特别是小干扰RNA(即siRNA)或能在细胞中产生siRNA以靶向表A1-A4所述基因的mRNA的核酸物质；其以一定量通过RNA干扰机制充分下调目标基因的表达。特别地，该方法可用于抑制治疗患有与眼部组织或细胞基因的表达相关的眼部障碍或疾病的受试者的基因表达。根据本发明，目标基因的siRNA分子或抑制剂被用作治疗各种眼部疾病的药物。

“核苷酸”指的是包括脱氧核苷酸和核糖核苷酸，其可能是天然的或合成的，和/或修饰的或未修饰的。修饰包括糖基的变化和取代，碱基和/或核苷酸间连接。

此处所使用的术语“非配对核苷酸类似物”指的是包括非碱基配对部分的核苷酸类似物，其包括但不仅限于：六德氨基腺苷(水粉荤素)、4-Me-吲哚、3-硝基吡咯、5-硝基吲哚、Ds、Pa、N3-Me ribo U、N3-MeriboT、N3-Me dC、N3-Me-dT、N1-Me-dG、N1-Me-dA、N3-ethyl-dC、N3-Me dC。在一些实施例中，非碱基配对核苷酸类似物是核糖核苷酸。在其他实施例中，它是脱氧核糖核酸。

所有核苷酸/寡核苷酸的类似物或修饰，可以用于本发明，只要所述类似物或修饰不显著影响核苷酸/寡核苷酸的稳定和功能。可接受的修饰包括糖基的修饰、碱基的修饰、核苷酸间连键及其组合的修饰。

在本发明中有时被称为“脱碱基核苷酸”或“脱碱基核苷酸类似物”的物质被更为恰当地称为伪核苷酸或非常规部分。核苷酸是核酸的单体单元，其组成为核糖或脱氧糖、磷酸盐和碱基(DNA中的腺嘌呤、鸟嘌呤、胸腺嘧啶或胞嘧啶；RNA中的腺嘌呤、鸟嘌呤、尿嘧啶或胞嘧啶)。一种修饰的核苷酸包括一种或多种糖、磷酸盐或碱基的修饰。脱碱基伪核苷酸缺乏碱基，因此不是严格的核苷酸。

此处使用的术语“盖基”包括脱碱基核糖基、脱碱基脱氧核糖基、包括2’O烷基的修饰脱碱基核糖和脱氧核糖基；反向脱碱基核糖基和脱碱基脱氧核糖基及其修饰；C6-亚氨基-Pi；包括L-DNA和L-RNA的镜像核苷酸；5’OMe核苷酸；包括4′，5′-亚甲基核苷酸的核苷酸类似物；1-(β-D-赤型呋喃酮酰基)核苷酸；4′-硫代核苷酸、碳环核苷酸；5′-氨基烷基磷酸酯；1，3-二氨基-2-丙基磷酸酯、3-氨丙基磷酸酯；6-氨己基磷酸酯；12-氨十二烷基磷酸酯；羟丙基磷酸酯；1，5-失水己糖醇核苷酸；α-核苷酸；苏型-戊呋喃酮酰基核苷酸；无环3′，4′-开环核苷酸；3，4-二羟丁基核苷酸；3，5-二羟戊基核苷酸；5′-5′-反向脱碱基；1，4-丁二醇磷酸酯；5′-氨基；以及桥接或非桥接甲基膦酸酯和5′-巯基。一种2’-O-甲基糖基修饰的核苷酸也被称为2′-OMe糖基修饰或2′-OMe修饰核苷酸。

某些优选的盖基是脱碱基核糖或脱碱基脱氧核糖基；反向脱碱基核糖基或脱碱基脱氧核糖基；C6-氨基-Pi；镜像核苷酸包括L-DNA和L-RNA。

此处所用的术语“非常规基团”指的是脱碱基核糖基、脱碱基脱氧核糖基、脱氧核糖核酸、修饰的脱氧核糖核酸、镜像核苷酸、非碱基配对核苷酸类似物和通过2’-5’核苷酸间磷酸键与相邻核苷酸连接的核苷酸；包括LNA和乙烯桥接核苷酸的桥接核苷酸。

脱碱基脱氧核糖基包括(例如)脱碱基脱氧核糖-3′-磷酸酯；1，2-脱氧-D-呋喃核糖三磷酸酯；1，4-脱水-2-脱氧-D-核糖醇-3-磷酸酯。反向脱碱基脱氧核糖基包括3′，5′反向脱氧脱碱基5′-磷酸酯。

在本发明中，“镜像”核苷酸(也称为spiegleMer)，是一个天然产生的手性反转核苷酸类似物或常用核苷酸，即天然产生或常用核苷酸的镜像。镜像核苷酸是核糖核苷酸(L-RNA)或脱氧核糖核苷酸(L-DNA)，且可进一步包括至少一种糖基或碱基修饰和/或骨架修饰，如硫代磷酸或膦酸酯基团。美国专利No.6,602,858披露了包括至少一种L-核苷酸替代物的核酸催化剂。镜像核苷酸包括(例如)L-DNA(L-脱氧核糖腺苷-3′-磷酸酯(镜像dA)；L-脱氧核糖胞啶-3′-磷酸酯(镜像dC)；L-脱氧核糖鸟苷-3′-磷酸酯(镜像dG)；L-脱氧核糖胸苷-3′-磷酸酯(镜像dT)和L-RNA(L-核糖腺苷-3′-磷酸酯(镜像rA)；L-核糖胞啶-3′-磷酸酯(镜像rC)；L-核糖鸟苷-3′-磷酸酯(镜像rG)；L-核糖尿嘧啶-3′-磷酸酯(镜像dU)。

修饰脱氧核糖核酸例如包括5′OMe DNA(5-甲基-脱氧核糖鸟苷-3′-磷酸酯)，其可用作5′末端位置的核苷酸(位点数：1)；PACE(脱氧核糖腺嘌呤3′膦酰基乙酸酯、脱氧核糖胞啶3′膦酰基乙酸酯、脱氧核糖鸟苷3′膦酰基乙酸酯、脱氧核糖胸苷3′膦酰基乙酸酯)。

桥接核酸包括LNA(2′-O，4′-C-亚甲基桥接核酸腺苷3′单磷酸酯，2′-O，4′-C-亚甲基桥接核5-甲基-胞苷3′单磷酸酯，2′-O，4′-C-亚甲基桥接核酸鸟苷3′单磷酸酯，5-甲基-尿苷(或胸苷)3′单磷酸酯)；和ENA(2′-O，4′-C-乙烯基桥接核酸腺苷3′单磷酸酯，2′-O，4′-C-乙烯基桥接核酸5-甲基-胞苷3′单磷酸酯，2′-O，4′-C-乙烯基桥接核酸鸟苷3′单磷酸酯，5-甲基-尿苷(或胸苷)3′单磷酸酯)。

在本发明的一些实施例中，优选的非常规基团是脱碱基核糖基、脱碱基脱氧核糖基、脱氧核糖核苷酸、镜像核苷酸、通过2’-5’核苷酸间磷酸键与相邻核苷酸连接的核苷酸。

根据一方面，本发明提供了抑制的寡核苷酸化合物，其中包括未修饰和修饰的核苷酸。该化合物包括选自由糖基修饰、碱基修饰和核苷酸间键修饰组成的组的至少一种修饰核苷酸，并可能包含DNA和修饰核苷酸，如LNA(锁核酸)，其中包括ENA(乙烯桥接核酸；PNA(肽核酸)；阿拉伯糖苷；PACE(膦酰基乙酸及其衍生物)，镜像核苷酸或含有6个碳糖的核苷酸。

在一个实施例中，该化合物包括至少一种核苷酸的糖基上的2’修饰(“2’糖基修饰”)。在某些实施例中，该化合物包括2’O-烷基或2’-氟代或2’O-烯丙基或任何其他的2’糖基修饰，任选地在交替的位置上。

其他的稳定修饰也是可能的(如添加到低聚物3′或5′末端的修饰核苷酸)。在一些实施例中，寡核苷酸是被修饰的，并包括磷酸-D-核糖的实体，但也可能包含硫代磷酸酯-D-核糖实体、三酯、硫代酯、2′-5′桥接骨架(也可简称为5′-2′)，PACE修饰核苷酸间键或任何其他类型的修饰。

其他修饰包含寡核苷酸5’和/或3’末端的附加物。这种末端修饰可以是脂类、肽类、糖或其他分子。

糖残基的可能修饰是多方面的，且包括2′-O烷基、锁核酸(LNA)、乙二醇核酸(GNA)、苏阿糖核酸(TNA)、阿拉伯糖苷；阿卓糖醇(ANA)和其他六元糖包括第三代反义寡核苷酸和环己菌素基。

国际专利申请No.WO 00/47599、WO 99/14226和WO 98/39352披露了LNA化合物。包括LNA核苷酸的siRNA化合物实例在ElMenet al.，(NAR 2005.33(1)：439-447)和国际专利申请No.WO2004/083430中披露。六元环核苷酸类似物在Allart，et al(Nucleosides& Nucleotides，1998，17：1523-1526；和Perez-Perez，et al.，1996，Bioorg.and Medicinal Chem Letters 6：1457-1460)中披露。包括六元环核苷酸类似物的寡核苷酸在国际专利申请No.WO 2006/047842中披露，其中所述六元环核苷酸类似物包括己糖醇和阿卓糖醇核苷酸单体。

骨架修饰，如乙基(结果是磷酸乙基三酯)；丙基(结果是磷酸丙三酯)；和丁基(结果是磷酸-丁三酯)也是可能的。其他骨架修饰包括聚合物骨架、骨架循环、非循环骨架、硫代-D-核糖骨架、酰胺化物和膦酰基乙酸衍生物。某些结构包括具有一个或多个2′-5′核苷酸间键(桥或骨架)的siRNA化合物。

本发明还涉及到下调各种基因表达的化合物，特别涉及新的小分子干扰RNA(siRNA)化合物，以及这些新的siRNA在治疗各种眼部疾病和眼睛病症中的用途。

每个基因都有19个低聚物序列的单独列表，其优先以它们专有算法的记分作为最佳的人类基因表达靶向序列的基础。21或23个碱基长度的siRNA序列可以通过此处的19个碱基序列的5′和/或3′端延伸而产生。优选地，这种延伸与到相应的mRNA序列互补。某23个低聚物通过这种方法设计，其中的优化顺序对应19个碱基的顺序。表B1-B36提供了用于制备siRNA.的人类正义和相应的反义寡核苷酸。跨物种的缩写是：Ms：鼠，Rb：兔，Chmp：黑猩猩，Mnk：猴，Chn：灰鼠，GP：荷兰猪。

眼部疾病

治疗型寡核苷酸化合物的局部传输用于治疗广谱的眼部疾病和障碍。本发明的某些化合物用于治疗患有疾病和障碍的病人，其中视神经的神经保护是有益的，例如：

1.原发性/继发性开角型青光眼

2.多发性硬化(视神经炎)

3.视网膜中央/分枝静脉阻塞

4.缺血性视神经病变(癫痫持续状态，HIV-1感染)

5.视神经损伤

6.肿瘤延伸到鞍区域(蝶鞍上方)

7.近交叉肿瘤(与垂体瘤压迫视交叉相关的视力丧失可能是暂时或永久性的，可能与视网膜神经节细胞不可逆的逆行变性的程度有关。

8.视网膜神经胶质瘤

原发性开角型青光眼

大部分青光眼的病例被认为是原发性开角型青光眼POAG的形式，也称慢性开角型青光眼。POAG是由于眼前房内的房水液体增加而造成眼内压(IOP)。高IOP，可以通过“眼压测量”试验测得，由液体进入眼睛造成，且不足以溢出眼睛。通常情况下，液体是通过渗出睫状体的血管而进入眼睛。这种液体最终朝晶状体方向流动，通过瞳孔(虹膜中央)，并进入虹膜-角膜角。形成虹膜和角膜结合的解剖角。然后该液体通过该角的小梁网，并通过巩膜静脉窦离开眼睛。

如果过多的液体进入眼睛，或者如果小梁网“排泄”被堵塞(例如，有杂物或细胞)，这样使得没有足够的液体离开眼睛，压力积聚在所谓的“开角型青光眼“内。当虹膜后部粘附到晶状体前表面形成“瞳孔阻滞”时，也可引起“开角型青光眼“，并防止眼内液体通过瞳孔进入前房。

如果虹膜和角膜之间的的角度过于狭窄或甚至封闭，然后液体倒流，引起所谓的“闭角型青光眼”内的压力增强。

未经治疗的青光眼最终导致视神经萎缩和失明。

正常眼压性青光眼

在美国约25-30％的青光眼的眼内压力是正常的(介于12-22mmHg)，被称为正常眼压性青光眼病症(在日本，比例可能高达70％)。导致视神经损伤的其他因素也存在，但不影响IOP。

闭角型青光眼

闭角型青光眼(也称为角性青光眼)是所有青光眼病例中15％引起的原因。在美国不如POAG常见，但由于在亚洲人中患病率高，其构成世界约一半的青光眼病例。该虹膜推挤晶状体，有时粘附于它，使其与引流角隔离。这种情况可能发生得很突然，导致压力的立即上升。当瞳孔突然收缩时，其通常发生在易得病人群中。闭角型青光眼也可以是慢性和平缓的，这是一种不太常见的情况。

先天性青光眼

先天性青光眼，是从出生时开始，其眼睛的排出通道不能正常排泄。这是非常罕见的，新生儿中发病的概率为约1万分之一。这可能是一种遗传性疾病，往往可以用显微手术矫正。

一方面，本发明提供了一种减弱患有青光眼受试者眼睛中目标眼部mRNA表达的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA和药学上可接受载体的有效量。在某些实施例中，至少一种眼部目标mRNA是选自表A1列表中如SEQ IDNO：1-35所述的基因产物。在某些优选实施例中，目标眼部mRNA是选自CASP2、ASPP1、TP53BP2、BNIP3、RTP801L、ADRB1和CAPNS1的基因产物。在目前的优选实施例中，siRNA以滴眼剂传输为配方。在不同实施例中，目标眼部mRNA如SEQ ID NO：1-2所述。

另一方面，本发明提供了一种治疗所需受试者青光眼的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的有效量，所述化学修饰siRNA抑制目标基因在受试者眼睛中的表达。在一些实施例中，该基因是选自表A1列表中的人类基因，其被转录为任一SEQ ID NO：1-35所述的mRNA。在某些优选实施例中，该基因是选自CASP2、ASPP1、TP53BP2、BNIP3、RTP801L、ADRB1和CAPNS1。在目前的优选实施例中，siRNA以滴眼剂传输为配方。在不同实施例中，目标眼部mRNA如SEQ ID NO：1-2所述。

视神经炎

视神经炎是视神经的炎症，可能影响神经和眼球内盘(乳头炎)或眼球(球后视神经炎)后面部分。视神经炎可能是由以下任何一项引起：脱髓鞘性病，如多发性硬化症或感染后脑脊髓炎；全身性病毒或细菌感染，其中包括炎症性疾病并发症(如鼻窦炎、脑膜炎、结核病、梅毒、脉络膜视网膜炎、眼眶炎症)；营养和代谢性疾病(如糖尿病、恶性贫血、甲状腺机能亢进)；遗传视神经病，一种罕见形式的遗传视神经病，主要影响年轻人；毒素(烟草、甲醇、奎宁、砷、水杨酸、铅)和创伤。

视神经萎缩

视神经萎缩症是一种遗传性或由视神经和视束神经纤维变性造成的视力丧失。这可能是通过视网膜中央静脉或动脉闭塞，动脉硬化改变引起，可继发于视网膜退化疾病，可能对视神经形成压力的结果，或者可能与代谢疾病(如糖尿病)、创伤、青光眼或毒性(酒精、烟草或其他有毒物质)有关。视神经纤维的变性和萎缩是不可逆的，虽然在一些病例中静脉注射类固醇被发现能减慢其过程。

视神经乳头水肿

视神经盘(乳头)肿胀，最常见的原因是颅内压增加(肿瘤诱导)、恶性高血压或视网膜中央静脉形成血栓。该疾病通常是双边的，神经头是非常升高和肿胀的，瞳孔反应通常是正常的。视力最初不会受到影响，眼球运动也没有疼痛。如果视神经乳头水肿不及时治疗，继发视神经萎缩和永久的视力丧失可能会发生。

缺血性视神经病变(ION)

由于滋养动脉的闭塞性障碍，供应视神经(通常在一只眼中)的动脉血液不足而造成严重的致盲疾病。视神经病变可以是前面的，从而导致视神经盘的苍白水肿，或面的，其中视神经盘不肿，但眼球和视交叉之间发生异常。前部缺血性视神经病变通常会导致视力丧失，可能会突然或在几天后发生。后部缺血性视神经病变并不常见，并且诊断在很大程度上取决于其他原因的排除，主要是中风和脑肿瘤。

其他疾病和障碍包括干眼症、糖尿病性视网膜病变、糖尿病性黄斑水肿和色素性视网膜炎。

干眼症

干眼症，又称为干燥性角膜结膜炎或干燥性角结膜炎，通常是由润滑眼睛的泪膜产物减少引起的常见问题。干眼症的大多数患者觉得不适，并没有丧失视力；虽然在严重情况下，角膜可能会损伤或感染。

干眼症是一种眼泪的多因性疾病，在眼睛表面发生，引起不舒服、视觉障碍以及在潜在损伤眼睛表面的泪膜不稳定性。它伴随着泪膜渗透压和眼睛表面炎症增加。

泪腺是由腺泡、导管和肌上皮细胞组成的多叶组织。腺泡细胞在泪腺细胞中占80％，是合成、贮存和蛋白质分泌的场所。这些蛋白质具有的抗菌(溶菌酶、乳铁蛋白)或生长因子(表皮生长因子、转化生长因子α、角膜细胞生长因子)性能对眼表面健康是至关重要的。该导管细胞的主要功能是修饰腺泡细胞分泌的原生流体，分泌水和电解质。该肌上皮细胞中含有多个过程，而腺泡和导管细胞底面积周围被认为是将液体压入和压出管道至眼表面。

泪腺功能失调机制

细胞凋亡、激素失衡、自身抗体产物、信号分子改变、神经功能障碍和炎性细胞因子水平的增加曾被认为是泪腺功能不全的可能介质。小儿干燥综合征的主要症状之一是干眼症。泪腺的腺泡和导管上皮细胞凋亡曾被认为是一种引起分泌功能损伤(Manganelli and Fietta，Semin Arthritis Rheum.2003.33(1)：49-65)的可能机制。不希望受理论束缚，凋亡的上皮细胞死亡可能是由于涉及Fas(Apo-1/CD95)、Fas(FasL/CD95L)、凋亡因子、凋亡蛋白酶、穿孔蛋白和颗粒酶的几个凋亡路径的激活。细胞毒性T细胞通过蛋白酶的释放，如穿孔蛋白和颗粒酶或以T细胞表达的FasL与上皮细胞Fas的相互作用，可导致腺泡细胞凋亡。

干眼症的目前治疗主要是局部和对症的，如：泪润滑剂补充；泪润湿治疗，如封泪管、水分室型眼镜或隐形眼镜；泪刺激，例如通过促分泌素；生物泪替代品；抗炎治疗(环孢菌素、类固醇、四环素)；和膳食的必需脂肪酸。

一方面，本发明提供了一种减弱患有干眼症受试者眼睛中目标眼部mRNA表达的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的有效量和药学上可接受的载体。在一些实施例中，该眼部目标mRNA是选自如表A2中如SEQ ID NO：5，8-10，26-27，30-44所述人类基因的产物。在一些实施例中，该目标眼部mRNA是选自FAS、FAS配位体(FASL)、p53、LRDD、PARP1、AIF(凋亡诱导因子)、NOS1、NOS2A、XIAP和SHC1-SHC。在某些优选实施例中，该目标眼部mRNA如任一SEQ ID NO：36-44所述。在目前的优选实施例中，该siRNA是以滴眼剂传输为配方。在不同实施例中，该受试者是患有小儿干燥综合症。在一些实施例中，siRNA的正义和反义链是选自表16-17中如SEQ ID NO：13225-15224所述的序列。

另一方面，本发明提供一种治疗所需受试者干眼症的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的治疗有效量，所述化学修饰siRNA抑制目标基因在受试者眼睛中的表达。在一些实施例中，该目标基因是选自表A2中的人类基因，其mRNA如任一SEQ ID NO：5、8-10、26-27或30-44所述。在一些实施例中，该目标基因是是选自FAS、FAS配位体(FASL)、p53、LRDD、PARP1、AIF(凋亡诱导因子)、NOS1、NOS2A、XIAP和SHC1-SHC。在某些优选实施例中，该目标基因mRNA如任一SEQ ID NO：36-44所述。在目前的优选实施例中，siRNA是以滴眼剂传输为配方。在不同实施例中，该受试者是患有小儿干燥综合症。在一些实施例中，siRNA的正义和反义链是选自表16-17中如SEQ ID NO：13225-15224所述的序列。

色素性视网膜炎

色素性视网膜炎(RP)代表了一组以渐进性周边视觉丧失和夜盲症为特征的遗传性疾病，可能导致中心视觉丧失。虽然病情发展可通过饮食中补充维生素A减弱，但目前还没有视网膜色素变性的治疗方法。

视锥杆感光细胞的细胞凋亡是RP中视网膜变性的关键过程，并代表了成人失明的主要原因。

一方面，本发明提供一种减弱患有色素性视网膜炎(RP)受试者眼睛的目标眼部mRNA表达的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的有效量和药学上可接受的载体。在一些实施例中，该眼部目标mRNA是选自表A4所列基因的基因产物，该基因被转录为任一SEQ ID NO：3、14、26-35、54-57所述的mRNA。在一些实施例中，该目标眼部mRNA是选自由CASP1、CASP3、CASP12、RTP801、RTP801L、钙蛋白酶S1、PARP1、AIF、NOS1、NOS2、XIAP和SHC1-SHC组成的组的基因产物。在目前的优选实施例中，该siRNA是以滴眼剂传输为配方。在某些优选实施例中，该siRNA目标mRNA如SEQ ID NO：56-57所述。在一些实施例中，siRNA的正义和反义链是选自表16-17中如SEQ ID NO：13225-15224所述的序列。

另一方面，本发明提供一种治疗所需受试者色素性视网膜炎(RP)的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的治疗有效量，所述化学修饰siRNA抑制目标基因在受试者眼睛中的表达。在一些实施例中，该目标基因是选自表A4所列的人类基因，被转录为如任一SEQ ID NO：3、14、26-35、54-57所述的mRNA。在一些实施例中，该基因是选自由CASP1、CASP3、CASP12、RTP801、RTP801L、钙蛋白酶S1、PARP1、AIF、NOS1、NOS2、XIAP和SHC1-SHC组成的组的人类基因。在目前的优选实施例中，siRNA是以滴眼剂传输为配方。在某些优选实施例中，该siRNA靶向和抑制如SEQ ID NO：56-57所述的mRNA。在一些实施例中，siRNA的正义和反义链是选自表11中如SEQ ID NO：9517-10516所述的序列。

糖尿病性视网膜病变

糖尿病性视网膜病变是糖尿病的并发症，并是导致失明的主要原因。它在当糖尿病损伤视网膜内的微小血管后发生。糖尿病性视网膜病变具有四个阶段：

-轻微的非增殖性视网膜病：视网膜内血管的小动脉瘤

-适度的非增殖性视网膜病：当该病发展时，滋养视网膜的血管被堵塞。

-严重的非增殖性视网膜病：更多的血管被堵塞，使视网膜的几个区域丧失了血液供给，胜过了新血管的增长。

-增殖性视网膜病：新血管随着视网膜和玻璃体凝胶表面而增长。当血管渗漏血液后，可能导致严重的视力丧失，甚至失明。

在怀孕期间，糖尿病视网膜病变可能是糖尿病女性的问题。

一方面，本发明提供一种减弱患有糖尿病视网膜病变受试者眼睛的目标眼部mRNA表达的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的有效量和药学上可接受的载体。在一些实施例中，该目标眼部mRNA是选自如表A3所列的基因产物，其含有任一SEQ ID NO：1-2、3、5、6-7、8-10、12、13、24-25、26-27、30-35、45-53所述的mRNA。在目前的优选实施例中，siRNA是以滴眼剂传输为配方。在某些优选实施例中，该目标眼部mRNA如任一SEQ ID NO：48-53所述。在一些实施例中，siRNA的正义和反义链是选自表4、28-32中的序列，如SEQ ID NO：2669-3648和25575-29594所述。

另一方面，本发明提供一种治疗所需受试者糖尿病视网膜病变的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的治疗有效量，所述化学修饰siRNA抑制目标基因在受试者眼睛中的表达。在一些实施例中，该目标基因是选自表A3所列的人类基因，其含有任一SEQ ID NO：1-2、3、5、6-7、8-10、12、13、24-25、26-27、30-35、45-53所述的mRNA。在目前的优选实施例中，siRNA是以滴眼剂传输为配方。在某些优选实施例中，该目标眼部mRNA如任一SEQ ID NO：48-53所述。在一些实施例中，siRNA的正义和反义链是选自表4、28-32中的序列，如SEQ ID NO：2669-3648和25575-29594所述。

不希望受理论束缚，糖尿病视网膜病变损伤的血管可从两方面导致视力丧失：脆弱的，异常血管可能生长，并渗漏血液进入眼睛中心，使视力模糊。这是增殖性视网膜病变，是该病的第四阶段和最晚期。该液体可渗入黄斑中心，导致视力模糊。这种疾病被称为黄斑水肿。它可以发生在糖尿病性视网膜病变的任何阶段，但更可能会随着病情的发展而发生，被称为糖尿病黄斑水肿(DME)。

老年性黄斑变性(AMD)

降低的最佳矫正的最常见原因，在美国65岁以上受试者视力是被称为老年性黄斑变性(AMD)的视网膜疾病。眼睛受AMD影响的区域是黄斑，其是视网膜中心的小区域，主要由感光细胞组成。随着AMD的发展，这种疾病的特点是中心视力的突然丧失。所谓的“干”AMD占AMD病人的85％-90％，并涉及到眼色素分布的改变，感光细胞的损伤和视网膜功能的减弱，这是由于整体细胞的萎缩。“湿”AMD涉及到视网膜下腔内导致血栓或疤痕的异常脉络膜血管的增生。因此，“湿”AMD的发病是由于神经视网膜下方异常脉络膜新生血管网络(脉络膜新生血管，CNV)的形成。新形成的血管过于渗漏。这导致视网膜下积液以及引起视敏度丧失的血液的积聚。最终，所涉及区域的视网膜功能完全丧失，作为一个包括脉络膜和视网膜形式的大型盘状疤痕。而干AMD病人可以保持质量下降的视力，湿AMD往往导致视力失明(Hamdi&Kenney，Frontiers in Bioscience，e305-314，May2003)。

一方面，本发明提供一种减弱患有AMD或DME受试者眼睛的目标眼部mRNA表达的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的有效量和药学上可接受的载体。在一些实施例中，该目标眼部mRNA是选自表A3所列的人类基因产物，其含有任一SEQ ID NO：1-2、3、5、6-7、8-10、12、13、24-25、26-27、30-35、45-53所述的mRNA。在目前的优选实施例中，siRNA是以滴眼剂传输为配方。在某些优选实施例中，该目标眼部mRNA是人类CTSD、RTP801和BNIP3的产物。

另一方面，本发明提供一种治疗所需受试者AMD或DME的方法，其中包括局部(无创伤性)向受试者眼睛表面施用至少一种化学修饰siRNA的治疗有效量，所述化学修饰siRNA抑制目标基因在受试者眼睛中的表达。在一些实施例中，该目标基因是选自表A3所列的人类基因，其含有任一SEQ ID NO：1-2、3、5、6-7、8-10、12、13、24-25、26-27、30-35、45-53所述的mRNA。在目前的优选实施例中，siRNA是以滴眼剂传输为配方。在某些优选实施例中，该目标眼部mRNA是人类CTSD、RTP801和BNIP3的目标人类基因。

由本发明化合物治疗的附加眼部疾病

病毒和细菌性疾病

与眼部组织相关的病毒和细菌性疾病可以由本发明的化合物治疗。结膜炎和其他眼睑疾病或病症可以被治疗，特别是根据本发明方法施用对目标基因复制和/或生物体存活必需的寡核苷酸(如siRNAs)。

与肿瘤相关的视力丧失

另一方面，本发明提供治疗与所需受试者肿瘤相关的视力丧失的方法，其中包括局部地无创伤性向受试者眼睛表面施用至少一种化学修饰的siRNA的治疗有效量，所述化学修饰的siRNA抑制与受试者肿瘤相关的至少一种基因的表达，其以一定量有效治疗视力丧失。

根据本发明，肿瘤导致视力丧失，其包括恶性肿瘤(癌症)和良性肿瘤。肿瘤包括任何眼部组织或任何眼部细胞的肿瘤，包括，但不仅限于，脉络膜肿瘤、结膜肿瘤、眼睑肿瘤、浸润性眼内肿瘤、虹膜肿瘤、转移性眼部肿瘤、视神经肿瘤、眼眶肿瘤及视网膜肿瘤。更具体地说，本发明涉及治疗的肿瘤及癌症的非详尽名单包括脉络膜肿瘤，如脉络膜血管瘤、脉络膜黑色素瘤、脉络膜转移瘤、脉络膜痣、脉络膜骨瘤、睫状体黑色素瘤和Ota痣；结膜肿瘤，如结膜卡波西氏肉瘤、眼球表面皮样囊肿、结膜淋巴瘤、非典型性的黑色素瘤和PAM、染色结膜肿瘤、睑裂黄斑、翼状胬肉、鳞状细胞癌及结膜上皮内瘤；眼睑肿瘤，如基底细胞癌、毛细血管瘤、汗腺囊瘤、睑缘痣、脂溢性角化病、眼睑恶性黑色素瘤、眼睑皮脂腺癌和眼睑鳞状细胞癌；浸润性眼内肿瘤，如慢性淋巴性白血病、眼睑肿瘤癌脉络膜及眼内淋巴瘤；浸润性脉络膜病和眼内淋巴瘤；虹膜肿瘤，如前段葡萄膜转移瘤、虹膜囊肿、虹膜黑色素细胞瘤、虹膜黑色素瘤和虹膜珍珠状囊肿；转移性眼部肿瘤，如转移性脉络膜黑色素瘤；视神经肿瘤，如影响视神经的脉络膜黑色素瘤、视神经病变的乳头周围转移瘤、视神经黑色素细胞瘤和视神经鞘脑膜瘤；眼眶肿瘤，如泪腺的腺样囊性癌、眼眶的海绵状血管瘤、眼眶的淋巴管瘤、眼眶黏液囊肿、眼眶炎性假瘤、眼眶横纹肌肉瘤、儿童眼周血管瘤及硬化型炎性假瘤；视网膜肿瘤，如视网膜色素上皮(RPE)增生、视网膜色素上皮(RPE)肿瘤、成视网膜细胞瘤、von Hippel血管瘤。

药物组合物

虽然本发明寡核苷酸化合物作为原料药施用也是可能的，最好是将其作为药物组合物施用。因此，本发明提供了一种药物组合物，其中包括本发明的一种或多种化合物；以及药学上可接受的载体。这种组合物可包括两种或多种/不同的寡核苷酸/siRNA的混合物.

本发明还提供了一种药物组合物，其中包括与本发明的一种或多种化合物共价或非共价连接的本发明的至少一种化合物，其以一定量有效抑制上述所公开的一种或多种基因；以及药学上可接受的载体。该化合物可通过内源性细胞复合物在细胞内生成，以产生本发明的一种或多种寡核糖核苷酸。

本发明还提供一种药物组合物，其中包括药学上可接受的载体和本发明的一种或多种化合物，其以一定量有效下调患有眼部疾病或障碍的受试者眼睛中的人类基因的表达。

本发明还提供了一种制备药物组合物的方法，包括：

提供本发明的一种或多种化合物；及

使所述化合物与药学上可接受的载体混合。

药学上可接受的载体，最好是由眼科给药领域的普通技术人员选择。

在不同实施例中，本发明的药物组合物包括至少一种本发明的siRNA化合物或其盐类，以重量计达99％，其与生理学上可接受的眼用载体介质混合，如水、氯化钠、缓冲剂、盐水(例如磷酸盐缓冲剂(PBS))、甘露醇等及其组合，以形成一种水相的眼用悬液或溶液。

该药物组合物可选择地另外包括至少一种眼科上可接受的防腐剂，比如苯扎氯铵。此外，眼科药物组合物可能包括眼科上可接受的表面活性剂，以协助溶解siRNA。

本发明的眼科药物组合物可能通过溶解或混合一种或多种干扰RNA与眼科上可接受的载体，比如一种生理学上可接受的等渗水相缓冲剂。

在优选实施例中，用于制备眼科药物组合物的siRNA化合物是与眼科上可接受的载体在药学上的有效剂量内混合。在某些优选实施例中，眼科上可接受的载体是PBS。

在一些实施例中，本发明的眼科药物组合物还包括附加的药学活性剂或药学活性剂的组合，如非甾体抗炎药、类固醇、抗生素等。

此外，相比于包括本发明一种或多种化合物与本发明基因的mRNA转录物接触的对照，本发明提供了一种抑制至少20％本发明基因的表达。在一些实施例中，相比于对照，活性siRNA化合物能够抑制至少20％、30％、40％、50％、60％或70％的基因表达水平。在某些优选实施例中，相比于对照，抑制至少75％、80％或90％的表达水平。

在一个实施例中，寡核糖核苷酸是抑制本发明的一种或多种基因，据此，该抑制是选自由基因功能抑制、多肽抑制和mRNA表达抑制组成的组。

在一个实施例中，该化合物能够抑制一种多肽，即该抑制是选自由功能抑制(尤其可能是通过具有已知的天然基因/多肽反应器进行酶法测定或键能测定)、蛋白质抑制(尤其可能是通过免疫印迹、酶联免疫吸附试验或免疫沉淀检测)及mRNA表达抑制(尤其可能是通过印迹法、定量RT-PCR、原位杂交或基因芯片杂交检测)组成的组。

联合治疗

本发明的化合物可以单独施用或与用于治疗眼部疾病或障碍的其他治疗药物组合施用。

在一些实施例中，本发明的眼科药物组合物还包括附加的药学活性剂或药学活性剂的组合，如寡核苷酸，例如：siRNA、非甾体抗炎药、类固醇、抗生素等。

在一个实施例中，两种或多种治疗剂的联合施用实现了协同效应，即，治疗剂的影响要大于对组合中单个成分的治疗作用总和。在另一个实施例中，两种或多种治疗剂的联合施用达到了累加效应。

包括联合治疗的有效成分可通过单剂量形式一起施用或每种活性剂单独施用。在某些实施例中，第一种和第二种治疗剂是以单剂量形式施用。该药剂可配制成局部施用的单一溶液。此外，第一种和第二种治疗剂可作为单独组合物施用。第一种活性剂可与第二种活性剂同时施用或者第一种活性剂可与第二种活性剂间歇性地施用。第一种和第二种治疗剂之间的时间长度可以调整，以达到理想的治疗效果。例如，第二种治疗剂可在施用第一种治疗剂几分钟(如1、2、5、10、30或60分钟)或几小时(如2、4、6、10、12、24或36小时)后施用。在某些实施例中，在第二种治疗剂施用之间施用治疗剂之一的一种以上剂量可能是有利的。例如，第二种治疗剂可在第一种治疗剂施用2小时后施用，然后10小时后施用。或者，在第二种治疗剂施用之间施用第一种治疗剂的一种以上剂量也可能是有利的。在某些实施例中，优选地，每种活性剂的治疗效果在每种治疗剂持续时间的至少一部分重叠，这样整体的联合治疗的治疗效果部分是由于该联合治疗的合并或协同效应。

传输

此处所公开的siRNA分子通过载体或稀释剂制得的分子直接施用被传输到眼睛的目标组织。

术语“裸siRNA”指的是不受用于协助、促进或方便进入细胞的任何传输载体或制剂(包括病毒序列、病毒粒子、脂质体制剂、脂质体或沉淀剂等)影响的siRNA分子。例如，PBS或眼科上可接受的制剂中的siRNA是“裸siRNA”。在本发明的某些实施例中，siRNA被作为裸siRNA传输。对于某些应用，增加siRNA在眼睛或鼻腔停留时间的制剂可能是需要的，例如，通过添加聚合物或增稠剂。

已经开发出特别涉及提高或改善siRNA传输的传输系统，(见，如，Shen et al FEBS Let.2003，539：111-114；Xia et al.，Nat.Biotech.2002，20：1006-1010；Reich et al.，Mol.Vision 2003，9：210-216；Sorensen et al.，J.Mol.Biol.2003.327：761-766；Lewis et al.，Nat.Gen.2002，32：107-108和SiMeoni et al.，NAR 2003，31，11：2717-2724)。

药学上可接受的载体、溶剂、稀释剂、赋形剂、佐剂和载体以及植入载体一般指的是惰性的无毒固体或液体填料，稀释剂或不与本发明活性成分反应的封装材料，它们包括脂质体和微球体。用于本发明的传输系统实例包括美国专利No.5,225,182；5,169,383；5,167,616；4,959,217；4,925,678；4,487,603；4,486,194；4,447,233；4,447,224；4,439,196和4,475,196。许多其他类似的植入物，传输系统和构件是所属领域的技术人员众所周知的。

局部眼部传输或鼻内传输的眼科药物组合物制备应考虑到多项因素，见Bar-Ilan and Neumann，in Textbook of Ocular Pharmacology，ZimMerman et al eds.，Lippencott-Raven 1997。

优选地，局部给药途径是向受试者提供有效剂量的治疗siRNA化合物。剂型可包括乳液、悬浮液、溶液、药膏等。在某些优选实施例中，包括至少一种siRNA本发明的药物组合物是以滴眼剂传输。在另一个实施例中，包括至少一种siRNA本发明的药物组合物是以喷雾或薄雾传输。例如，美国专利No.4,052,985披露了眼科喷雾涂抹器。

在本发明的某些实施例中，siRNA局部地达到其目标细胞，例如，直接接触或通过细胞、组织或细胞内液扩散。本发明的siRNA或药物组合物是根据良好医疗实践的剂量给药，同时考虑到个别病人的临床状况、治疗的疾病、给药计划、病人年龄、性别、体重及医生公知的其他因素。

因此，此处所涉及的“治疗有效剂量”是通过所属技术领域的这种考虑确定的。剂量必须是有效的，以实现改善，包括但不限于病程的改善，更迅速的恢复，症状的改善，症状的消除和由所属技术领域的普通技术人员视情况而选择的其它指标。本发明的siRNA可以单剂量或多剂量给药。

一般来说，人类化合物的活性剂量范围为1ng/kg至约20-100mg/kg体重每天，优选为0.01mg/kg至约2-10mg/kg体重每天，在单剂量或多剂量的方案中，每天一剂到每天两次、三次或多次。在某些实施例中，siRNA化合物被配制成滴眼剂局部施用到眼睛上，按组合物体积计包括约5μg/μl至约60μg/μl、按组合物体积计包括约6.6μg/μl、按组合物体积计包括约25μg/μl、按组合物体积计包括约33.3μg/μl、按组合物体积计包括约50μg/μl。

配方的pH值为约pH 5至约pH 8，或约pH 5至约pH 7，或pH5至约pH 6。在某些实施例中，pH值为约pH5.9、约pH 6.15、约pH 6.25、约pH 6.3、约pH 6.5、约pH 7.25。本发明的化合物可以局部施用到眼睛表面上。应当指出，优选地，该化合物被作为化合物或药学上可接受的盐活性成分与药学上可接受的载体、溶剂、稀释剂、赋形剂、佐剂和或载体结合使用。此处所披露的优选传输方法是向眼睛局部施用眼科组合物。

液体形式可通过滴剂或喷雾制得。液体组合物包括水溶液、有或无有机共溶剂、水相或油相悬浮液、含食用油的乳液以及类似的药物载体。

这些化合物可通过任何适当的给药路径向人类和其它动物的眼睛给药以进行治疗，通过，例如，喷雾或滴剂给药，以及通过药膏或滴剂局部给药。

治疗方法

一方面，本发明涉及一种治疗与所需受试者眼睛中表A1-A4所列基因的表达相关的眼部疾病或障碍的方法，其中包括局部无创伤性地向受试者眼睛表面施用一定量的化学修饰siRNA，所述化学修饰siRNA抑制至少一种基因的表达。在某些优选实施例中，施用一种或多种目标基因的多种siRNA。

在优选实施例中，正在接受治疗的受试者是温血动物，尤其是，包括人类的哺乳动物。

本发明的方法包括局部无创伤性地向受试者施用一种或多种下调表A1-A4的基因表达的抑制化合物；尤其是有效治疗剂量的siRNA，从而治疗该受试者。

术语“治疗”指的是治疗和预防疾病或预防措施，其中目的是防止或减缓，减轻如上述的相关眼部疾病。需要治疗者包括那些已经患有疾病或病症、那些具有发生疾病或病症倾向以及那些预防疾病或病症的人。本发明的化合物可在眼部疾病或病症或与其相关的症状发病之前、期间或之后施用。在治疗是为了预防的情况下，那么本发明涉及一种延迟发病或避免疾病或障碍发展的方法。

眼部疾病包括急性带状隐匿性外层视网膜病变、艾迪综合征、老年性黄斑变性、弱视、无虹膜、瞳孔不等、无眼畸胎、无晶状体、睑缘炎、上睑下垂、睑痉挛、失明、白内障、睑板腺囊肿、脉络膜视网膜炎、无脉络膜、缺损、结膜疾病、结膜炎、角膜疾病、角膜营养不良、角膜水肿、角膜溃疡、糖尿病黄斑水肿、糖尿病视网膜病变、复视、双行睫，干眼综合征、眼球后退综合征、睑外翻、眼内炎、睑内翻、内斜视、剥脱综合征、外斜视、眼部畸形、眼肿瘤、广泛纤维化综合征、青光眼、回旋形萎缩、偏盲、白化病综合症、麦粒肿、霍纳综合征、远视、眼前房出血、虹膜炎、卡恩斯-萨耶尔综合症、角膜炎、圆锥形角膜、泪器疾病、泪道阻塞、晶状体疾病、黄斑变性、眼球震颤、病理性疾病、眼球运动障碍、动眼神经神经疾病、眼肌麻痹、视神经萎缩、遗传性疾病、视神经疾病、视神经炎、缺血性视神经病变、眶蜂窝织炎、视神经乳头水肿、老花眼、翼状胬肉、瞳孔畸形、屈光不正、视网膜脱离、视网膜病、视网膜静脉阻塞、视网膜母细胞瘤、视网膜色素变性、早产儿视网膜病、视网膜裂、巩膜炎、盲点、斜视、小儿干燥综合征，Thygeson浅层点状角膜炎、沙眼、葡萄膜炎。

寡核苷酸

优选地，用于此处披露方法的寡核苷酸是双链寡核苷酸和siRNA化合物，并包括未修饰和化学和/或结构修饰的化合物。

与已知基因相应的siRNA的选择与合成已被广泛报道；见，例如，Ui-Tei et al.，J BioMed Biotechnol.2006；65052；Chalk et al.，BBRC.2004，319(1)：264-74；Sioud & Leirdal，Met.Mol Biol.2004，252：457-69；Levenkova et al.，Bioinform.2004，20(3)：430-2；Ui-Tei et al.，NAR.2004，32(3)：936-48.例如，修饰siRNA的使用和生产，见，例如，Braasch et al.，Biochem.2003，42(26)：7967-75；Chiu et al.，RNA.2003，9(9)：1034-48；PCT公布第WO 2004/015107号和WO 02/44321号以及美国专利第5,898,031号和第6,107,09号。

本发明提供了下调所需基因表达的双链寡核苷酸(如siRNAs)。本发明的siRNA是寡核糖核苷酸双链，其中正义链是来自所需基因的mRNA序列，反义链是与正义链互补的。一般而言，目标mRNA序列的一些偏差是可接受的，也不会破坏siRNA活性(见，如Czaudernaet al.，NAR.2003，31(11)：2705-2716)。本发明的siRNA在破坏或不破坏mRNA的情况下能在转录后水平上抑制基因表达。不希望受理论束缚，siRNA可能靶向mRNA，进行特异性裂解和降解和/或可能会抑制目标信息的转录。

在一些实施例中，siRNA是钝端的，即Z和Z′是缺失的，在一端或两端。更具体地说，siRNA可能在由第一链5′-端和第二链3′-末端和/或由第一链3′-端和第二链5′-端规定的末端是钝端的。

在其他的实施例中，至少一条或两条链可能在至少一种核苷酸的5′端具有悬突；该悬突可能由至少一个脱氧核苷酸组成。至少一条链也可能选择性地在至少一种核苷酸3′-端具有悬突。该悬突可能由1至5个核苷酸组成。

RNA双链的长度是约18至40个核糖核苷酸，优选为19、21或23个核苷酸。此外，每一条链的长度可能独立地选自由约15至约40个碱基组成的组的长度，优选为18至23个碱基，较优选为19、21或23个核糖核苷酸。在一些实施例中，20或22个碱基分子可能是预期的。

在某些实施例中，所述第一链和目标核酸之间的互补性是完美的(100％)。在一些实施例中，链是基本上互补的，即所述第一链和目标核酸之间有1个、2个或最多3个错配。基本上互补指的是与另一个序列的互补性大于约84％。例如，由19个碱基对及1个错配组成的双链区域造成94.7％的互补性，2个错配造成约89.5％的互补性，3个错配造成约84.2％的互补性，表现为大量的双链区域基本上互补。因此基本上相同指的是与另一个序列的同一性大于约84％。

第一条链和第二链可通过循环结构连接，其可能是由非核酸聚合物组成，特别是，如聚乙二醇。另外，循环结构可能是由核酸组成，其中包括修饰和非修饰核糖核苷酸以及修饰和非修饰脱氧核糖核苷酸。

此外，siRNA第一链的5′-末端可能与第二链的3′-末端连接，或第一链的3′-末端可能与第二链的5′-末端连接，所述通过核酸连接键的连接通常具有2-100个核碱基的长度，优选为约2至约30个核碱基。

在本发明化合物的优选实施例中，所述化合物的至少一个正义和反义链上具有交替的核苷酸修饰，反义链5’和3’末端的19个碱基和23个碱基低聚物的核糖核苷酸在其糖残基是修饰的，而正义链5’和3’末端的核糖核苷酸在其糖残基是未修饰的。正义链5’和3’末端的21个碱基低聚物的核糖核苷酸在其糖残基是修饰的，而反义链5’和3’末端的核糖核苷酸在其糖残基是未修饰的，或者可能在3′末端有可选的其他修饰。如上所述，优选地，反义链中间的核苷酸链是未修饰的。

此外，本发明提供一种包括双链核酸分子的siRNA，其中一条链或两条链上的1、2或3个核苷酸被取代，从而提供至少一个错配的碱基对。每一条链的取代核苷酸优选为在一条链或两条链的末端区域。

根据本发明的一个优选实施例，寡核苷酸/siRNA的正义和反义链只在3′-末端是磷酸化的，而不是在5′-末端。根据本发明的另一个优选实施例，反义和正义链都是非磷酸化的。根据本发明的又一个优选的实施例，正义链的5′末端核糖核苷酸是修饰的，以取消体内5′-磷酸化的任何可能性。

此处所披露的任何siRNA序列可以制成具有任何的修饰/结构。序列加上结构的组合是新的，可用于治疗此处披露的疾病。

siRNA结构

与已知基因相应的siRNA的选择与合成已被广泛报道；(见，如Ui-Tei et al.，J BioMed Biotech.2006；2006：65052；Chalk et al.，BBRC.2004，319(1)：264-74；Sioud & Leirdal，Met.Mol Biol.；2004，252：457-69；Levenkova et al.，Bioinform.2004，20(3)：430-2；Ui-Tei etal.，NAR.2004，32(3)：936-48)。

有关修饰siRNA使用和生产的实例，例如，Braasch et al.，Biochem.2003，42(26)：7967-75；Chiu et al.，RNA，2003，9(9)：1034-48；PCT申请WO 2004/0151072004/015107(atugen AG)和WO 02/44321(Tuschlet al)。美国专利No.5,898,031和2005/0042647披露了化学修饰低聚物。美国专利申请No.2005/0080246和2005/0042647分别涉及到具有化学修饰核苷间连接的一个交替序列和双链RNA化合物。

其他修饰已经披露。5′-磷酸基团的引入提高了果蝇胚胎中siRNA的活性(Boutla，et al.，Curr.Biol.2001，11：1776-1780)，对人类HeLa细胞中siRNA功能是必要的(Schwarz et al.，Mol.Cell，2002，10：537-48)。Amarzguioui et al.，(NAR，2003，31(2)：589-95)显示siRNA活性取决于2’-O-甲基(2’-OMe)修饰物的位点。据Holen et al(NAR.2003，31(9)：2401-07)报道，与原生型相比，具有少量2’-OMe修饰核苷的siRNA显示出良好的活性，但活性随着2’-OMe修饰核苷数量的增加而降低。Chiu和Rana(RNA.2003，9：1034-48)指出正义或反义链(完全修饰的链)中2’-OMe修饰核苷的引入相对于未修饰的siRNA，大大降低了siRNA的活性。据报道，2’-OMe基在反义链5′-末端的位置严重限制了活性，而反义链3′-末端的位点和正义链的两个末端是可接受的(Czauderna et al.2003，31(11)：2705-16；WO 2004/015107)。本发明的分子提供了一种优势，这是因为它们是无毒的，并可以配制成治疗各种疾病的药物组合物。

核苷酸可以从天然或合成修饰的碱基中选择。天然碱基包括腺嘌呤、鸟嘌呤、胞嘧啶、胸腺嘧啶和尿嘧啶。核苷酸的修饰碱基包括次黄嘌呤核苷、黄嘌呤、次黄嘌呤、2-氨基腺嘌呤、6-甲基、2-丙基和其他烷基腺嘌呤、5-卤尿嘧啶、5-卤胞嘧啶、6-氮杂胞嘧啶和6-氮杂胸腺嘧啶、假尿嘧啶、4-硫脲嘧啶、8-卤腺嘌呤，8-氨基腺嘌呤、8-巯基腺嘌呤、8-巯基烷基腺嘌呤、8-羟基腺嘌呤和其他8-取代腺嘌呤、8-卤鸟嘌呤、8-氨基鸟嘌呤、8-巯基鸟嘌呤、8-巯基烷基鸟嘌呤、8-羟基鸟嘌呤和其他取代鸟嘌呤、其他氮杂和去氮杂腺嘌呤、其他氮杂和去氮杂鸟嘌呤、5-三氟甲基尿嘧啶和5-三氟胞嘧啶。本发明包括一种或多种脱碱基基团(非常规的或假核苷酸)的分子，以及包括交替RNA和DNA核苷酸的分子。

此外，多核苷酸类似物可以制得，其中一种或多种核苷酸的结构根本地改变，更好地适合作为治疗或实验试剂。一种核苷酸类似物的实例是肽核酸(PNA)，其中DNA(或RNA)中的脱氧核糖(或核糖)磷酸骨架被与肽发现相似的聚酰胺骨架取代。PNA类似物已被证明能抗酶降解，并能在体内和体外延长生命。

对糖残基的可能修饰是多方面的，包括2′-O烷基、锁核酸(LNA)、乙二醇核酸(GNA)、苏糖核酸(TNA)、阿拉伯糖苷、阿卓糖醇(ANA)以及包括吗啉代和环己菌素基的其他六元糖。此外，所述分子可以另外包含对糖的修饰，如2′烷基、2′氟、2′O烯丙基、2′胺基和2′烷氧基。此处将讨论另外的糖基修饰。

LNA化合物在国际专利申请No.WO 00/47599，WO 99/14226和WO 98/39352中有所披露。包括LNA核苷酸的siRNA化合物的实例在ElMen et al.，(NAR 2005.33(1)：439-447)和PCT专利申请No.WO2004/083430有所披露。

本发明的化合物可以采用一种或多种反向核苷酸合成，例如，反向胸苷倒或反向腺嘌呤(例如，见Takei，et al.，2002.JBC277(26)：23800-06)。

骨架修饰，如乙基(产生磷酸三乙酯)；丙基(产生磷酸三丙酯)和丁基(产生磷酸三丁酯)也是可能的。其他骨架修饰包括聚合物骨架、环骨架、非环骨架、硫代磷酸酯-D-核糖骨架、酰胺化物和磷酰基乙酸衍生物。某些结构包括具有一个或多个2′-5′核苷酸间连键(桥或骨架)的siRNA化合物。

此外，本发明抑制核酸分子可能包括一个或多个缺口和/或一个或多个裂口和/或一个或多个错配。不希望受理论束缚，缺口、裂口和错配由于处于使核酸/siRNA部分动摇的优势，因此更可能通过内生的细胞机器如DROSHA或RISC加工成抑制成分。

除了编码这种分子或其他抑制核酸分子的其他核酸序列或分子外，本发明的分子还可包括siRNA、合成的siRNA、shRNA和合成的shRNA。

本发明的化合物可进一步包括末端修饰。生物素基团可以连接到第一和/或第二链5′末端或3′末端或两端的核苷酸上。在一个较优选实施例中，生物素基团是耦合到多肽或蛋白质上。这也是在本发明的范围，该多肽或蛋白质是通过上述其他任何修饰而连接。

优选地，此处所披露的各种末端修饰，是在核酸的核糖核苷酸的核糖基。特别是，末端修饰可能连接或取代核糖基的任何OH-基，包括但不仅限于2′OH、3′OH和5′OH位置，条件是，修饰的核苷酸是末端核苷酸。反向脱碱基或脱碱基是核苷酸，脱氧核糖核苷酸或者核糖核苷酸不具有核苷碱基。这种化合物是，特别是在Sternberger，et al.，(Antisense Nucleic Acid Drug Dev，2002.12，131-43)有所描述。

在本发明的背景下，核酸的缺口指的是一条链缺乏一个或多个内部核苷酸，而核酸的裂口指的是一条链缺乏两个相邻核苷酸之间的核苷酸间连键。本发明的任何分子可包括一个或多个缺口和/或一个或多个裂口。本发明进一步提供由此处披露的任何分子编码的一种siRNA分子，编码此处披露任何分子的一种载体及包括编码它们的此处披露的任何分子或载体的一种药物组合物；以及药学上可接受的载体。

根据本发明方法施用的特定分子通过下面的标题“结构基序”进行了披露。为清楚起见，任何这些分子可以根据本发明的任何方法施用。

结构基序

此处所披露的siRNA化合物是根据以下结构所述的一种修饰或用于本发明方法的串联siRNA或RNAstar(见下文)进行化学和/或结构修饰。表1-36提供了正义和反义的寡核苷酸对，如SEQ IDNO：59-33596所述，用于制备相应的siRNA化合物。

一方面，本发明提供一种如结构(A)所述的化合物：

(A)5’(N)_x-Z     3’(反义链)

3’Z’-(N’)_y    5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)_x和(N’)_y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，每个x和y是介于18至40的整数；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在3’末端共价连接的话，其是存在的；以及

其中，(N)x的序列包括与基因的mRNA中约18至约40个连续核苷酸大体互补的反义序列，所述基因在视网膜内表达且与眼部疾病或障碍相关。在一些实施例中，mRNA如任一SEQ ID NO：1-58所述。

在某些实施例中，本发明提供一种如结构B所述的化合物：

(B)5’(N)_x    3’反义链

3’(N’)_y     5’正义链

其中，每个(N)_x和(N’)_y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，每个x和y＝19、21或23，且(N)_x和(N‘)_y是完全互补的

其中，每个(N)_x和(N’)_y中的交替核糖核苷酸包括2’-OMe糖基修饰核糖核苷酸；

其中，(N’)_y的序列是与(N)_x互补的序列；且其中(N)_x的序列包括与任一SEQ ID NO：1-58所述mRNA中的约18至约40个连续核糖核苷酸大体互补的反义序列。

在一些实施例中，每个(N)_x和(N’)_y在3’和5’末端是独立磷酸化或非磷酸化的。

在本发明的某些实施例中，该化合物的反义和正义链中的交替核糖核苷酸是修饰的。

在某些实施例中，其中，每个x和y＝19或23，(N)x的5’和3’末端上的每个N是修饰的；以及

在(N’)y的5’和3’末端上的每个N’上是修饰。

在某些实施例中，其中，(N)x的5’和3’末端上的每个N是修饰的；(N’)y的5’和3’末端上的每个N’是修饰的。

在特定的实施例中，当x和y＝19时，siRNA是由反义链(N)x的第一、第三、第五、第七、第九、第十一、第十三、第十五、第十七和第十九个核苷酸上的2’OMe修饰核糖核苷酸和正义链(N’)y的第二、第四、第六、第八、第十、第十二、第十四、第十六和第十八个核苷酸上的2’OMe修饰核糖核苷酸组成。在不同实施例中，这些特定的siRNA化合物在两末端是钝端的。

在某些实施例中，本发明提供一种如结构(C)所述的化合物：

(C)    5’(N)_x-Z        3’反义链

      3’Z’-(N’)_y     5’正义链

其中，每个N和N’是独立选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸和修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸且每个X和Y是介于18至40的整数；

其中，在(N)x中，核苷酸是未修饰的或(N)x包括交替2’O Me糖基修饰核糖核苷酸和未修饰核糖核苷酸；其中，核糖核苷酸在被2’OMe糖基修饰或未修饰的(N)x的中间位置，优选为未修饰的；

其中，(N’)y包括在末端或倒数第二位置进一步含有一个修饰核苷酸的未修饰核糖核苷酸，其中修饰核苷酸是选自由镜像核苷酸、双环核苷酸、2’-糖基修饰核苷酸、阿卓糖醇核苷酸或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组。

其中，如果(N’)y中一个以上的核苷酸是修饰的，则修饰核苷酸可能是连续的；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在3’末端共价连接的话，其是存在的；以及

其中，(N’)y的序列包括与(N)x大体互补的序列；其中，(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中的约18至约40个连续核糖核苷酸大体互补的反义序列。

在特定实施例中，x＝y＝19，且在(N)x中，每个修饰核糖核苷酸是2’-OMe糖基修饰的，(N)x中间的核糖核苷酸是未修饰的。因此，在化合物中，其中x＝19，(N)x包括在位点1、3、5、7、9、11、13、15、17和19是2’-OMe糖基修饰的核糖核苷酸。在其他实施例中，(N)x包括在位点2、4、6、8、11、13、15、17和19是2’-OMe糖基修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点5。在其他实施例中，(N)x包括在位点2、4、8、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点6。在其他实施例中，(N)x包括在位点2、4、6、8、11、13、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点15。在其他实施例中，(N)x包括在位点2、4、6、8、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点14。在其他实施例中，(N)x包括在位点1、2、3、7、9、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点5。在其他实施例中，(N)x包括在位点1、2、3、5、7、9、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点6。在其他实施例中，(N)x包括在位点1、2、3、5、7、9、11、13、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点15。在其他实施例中，(N)x包括在位点1、2、3、5、7、9、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点14。在其他实施例中，(N)x包括在2、4、6、7、9、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点5。在其他实施例中，(N)x包括在位点1、2、4、6、7、9、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点5。在其他实施例中，(N)x包括在位点2、4、6、8、11、13、14、16、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点15。在其他实施例中，(N)x包括在位点1、2、3、5、7、9、11、13、14、16、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点15。在其他实施例中，(N)x包括在位点2、4、6、8、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点7。在其他实施例中，(N)x包括在位点2、4、6、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点8。在其他实施例中，(N)x包括在位点2、4、6、8、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点9。在其他实施例中，(N)x包括在2、4、6、8、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点10。在其他实施例中，(N)x包括在2、4、6、8、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点11。在其他实施例中，(N)x包括在2、4、6、8、11、13、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点12。在其他实施例中，(N)x包括在2、4、6、8、11、15、17和19是2’-OMe修饰的核糖核苷酸，可能还包括一种脱碱基或反向脱碱基假核苷酸，例如在位点13。

在另一个实施例中，相比于目标基因，(N)x包括至少一个核苷酸错配。在某些优选实施例中，(N)x包括一个在位点5、6或14的单核苷酸错配。在结构(C)的一个实施例中，(N’)y的至少两个核苷酸在任何或所有的5’和3’末端通过2’-5’磷酸二酯键连接。在某些优选实施例中，x＝y＝19或x＝y＝23；在(N)x中，核苷酸在2’-OMe糖基修饰核糖核苷酸和未修饰核糖核苷酸以及未被修饰的(N)x中间的核糖核苷酸这几种状态间交替变化；(N’)y的3’末端的3个核苷酸通过2’-5’磷酸二酯键(如此处的结构I所示)连接。在其他优选实施例中，x＝y＝19或x＝y＝23；在(N)x中，核苷酸在2’-OMe糖基修饰核糖核苷酸和未修饰核糖核苷酸以及未被修饰的(N)x中间的核糖核苷酸这几种状态间交替变化；(N’)y的5’末端的4个连续核苷酸通过2’-5’磷酸二酯键(如此处结构I所述)连接。在一个进一步的实施例中，(N)y中间的附加核苷酸是2’-OMe糖基修饰。在另一个优选实施例中，在(N)x中，核苷酸在2’-OMe糖基修饰核糖核苷酸和未修饰核糖核苷酸这两种状态间交替变化；(N’)y的5’末端的4个连续核苷酸通过2’-5’磷酸二酯键(如此处结构I所述)连接。5’末端核苷酸或5’末端的2个或3个连续核苷酸包括3’-O-甲基(3’-OMe)修饰物。

在结构C的某些优选实施例中，x＝y＝19；在(N’)y中，至少一个位点包括脱碱基或反向脱碱基假核苷酸，优选为在位点5包括脱碱基或反向脱碱基假核苷酸。在不同实施例中，以下位点包括脱碱基或反向脱碱基假核苷酸：位点1及16-19、位点15-19、位点1-2和17-19、位点1-3和18-19、位点1-4和19、位点1-5。(N’)y可能还包括至少一个LNA核苷酸。

在结构C的某些优选实施例中，x＝y＝19；在(N’)y中，核苷酸的至少一个位点包括镜像核苷酸、脱氧核糖核苷酸以及通过2’-5’磷酸二酯键连接的核苷酸。

在结构C的某些优选实施例中，x＝y＝19，(N’)y包括镜像核苷酸。在不同实施例中，镜像核苷酸是L-DNA核苷酸。在某些实施例中，L-DNA是脱氧核糖胞啶。在一些实施例中，(N’)y包括位点18上的L-DNA。在其他实施例中，(N’)y包括位点17和18上的L-DNA。在某些实施例中，(N’)y包括位点2以及位点17和18中的一个或两个上的L-DNA取代基。在某些实施例中，(N’)y还包括终端帽核苷酸，如5’-O-甲基DNA或脱碱基或反向脱碱基假核苷酸作为悬突。

在另一个实施例中，相对于目标基因，(N’)y包括至少一个核苷酸错配。在某些优选实施例中，(N’)y包括位点6、14或15上的单核苷酸错配。

在另一个实施例中，(N’)y包括位点15上的DNA以及位点17和18中的一个或两个上的L-DNA。在这种结构中，位点2还可能包括L-DNA或脱碱基假核苷酸。

结构C的其他实施例是设想的，其中x＝y＝21或x＝y＝23；在这些实施例中，上文讨论的(N’)y修饰中，对于21个碱基和23个碱基，修饰位点是17、18、19、20和19、20、21、22，而不是15、16、17、18；同样地，对于21个碱基，修饰位点是17和18中的一个或两个或19和20中的一个或两个；对于23个碱基，修饰位点是21和22。对于21个碱基和23个碱基，19个碱基的所有修饰是同样调整的。

根据结构C的不同实施例，在(N’)y中，3′末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸通过2’-5’核苷酸间连键连接。在一个优选实施例中，(N’)y中3′末端的4个连续核苷酸通过3个2’-5’磷酸二酯键连接，其中，一个或多个2’-5’核苷酸形成磷酸二酯键，还包括3’-O-甲基糖基修饰。优选地，(N’)y的3’末端核苷酸包括2’-O-甲基糖基修饰。在结构C的某些优选实施例中，x＝y＝19，(N’)y中位点15、16、17、18和19的两个或多个连续核苷酸包括通过2’-5’核苷酸间键与相邻核苷酸连接的核苷酸。在不同实施例中，形成2’-5’核苷酸间键的核苷酸包括3’脱氧核糖核苷酸或3’甲氧基核苷酸。在一些实施例中，(N’)y中位点17和18的核苷酸通过2’-5’核苷酸间键连接。在其他实施例中，(N’)y中位点16、17、18、16-17、17-18或16-18的核苷酸通过2’-5’核苷酸间键连接。

在某些实施例中，(N’)y包括位点2的L-DNA和位点16、17、18、16-17、17-18或16-18的核苷酸间键。在某些实施例中，(N’)y包括位点16、17、18、16-17、17-18或16-18的2’-5’核苷酸间键和5’终端帽核苷酸。

根据结构(C)的不同实施例，在(N’)y中，任何末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸或每个5’和3′末端的2-8个修饰核苷酸是独立的镜像核苷酸。在一些实施例中，镜像核苷酸是L-核糖核苷酸。在其他施例中，镜像核苷酸是L-脱氧核糖核苷酸。镜像核苷酸还可在糖基或碱基或核苷酸间连键内进行修饰。

在结构(C)的一个优选实施例中，3’末端核苷酸或(N’)y中3’末端的2个或3个连续核苷酸是L-脱氧核糖核苷酸。

在结构(C)的其他实施例中，(N’)y中任何末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸或每个5’和3′末端的2-8个修饰核苷酸是独立的2’糖基修饰核苷酸。在一些实施例中，2’糖基修饰包括氨基、氟代、烷氧基或烷基。在某些实施例中，2’糖基修饰包括甲氧基(2’-OMe)。

在一系列的优选实施例中，(N’)y中5’末端的3、4或5个连续核苷酸包括2’-OMe修饰。在另一个优选实施例中，(N’)y中3’末端的3个连续核苷酸包括2’-O-甲基修饰。

在结构(C)的一些实施例中，(N’)y中任何末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸或每个5’和3′末端的2-8个修饰核苷酸是独立的双环核苷酸。在不同实施例中，双环核苷酸是锁核酸(LNA)。2′-O，4′-C-乙烯基-桥接核酸(ENA)是一种LNA(见下文)。

在不同实施例中，(N’)y包括5’末端或3’和5’末端的修饰核苷酸。

在结构(C)的一些实施例中，(N’)y的5’和3’末端中的一个或两个的至少两个核苷酸是通过P-乙氧基骨架修饰连接。在某些优选实施例中，x＝y＝19或x＝y＝23；在(N)x中，核苷酸在修饰核糖核苷酸或未修饰核糖核苷酸这两个状态间交替变化，每个修饰核糖核苷酸的修饰是为了在其糖基和未修饰(N)x的中间位置的核糖核苷酸上具有2’-O-甲基；(N’)y中3’末端或5’末端的4个连续核苷酸是通过3个P-乙氧基骨架修饰连接。在另一个优选实施例中，(N’)y中3’末端或5’末端的3个连续核苷酸是通过2个P-乙氧基骨架修饰连接。

在结构(C)的一些实施例中，(N’)y中每个5’和3′末端的2、3、4、5、6、7或8个连续核糖核苷酸是独立的镜像核苷酸、通过2’-5磷酸二酯键连接的核苷酸、2’糖基修饰核苷酸或双环核苷酸。在一个实施例中，(N’)y中5’和3′末端的修饰是相同的。在一个优选实施例中，(N’)y中5’末端的4个连续核苷酸通过2’-5磷酸二酯键连接以及3个连续核苷酸通过2个2’-5磷酸二酯键连接。在另一个实施例中，(N’)y中5’末端修饰不同于(N’)y中3’末端修饰。在一个特定实施例中，(N’)y中5’末端的修饰核苷酸是镜像核苷酸，(N’)y中3’末端的修饰核苷酸通过2’-5磷酸二酯键连接。在另一个特定实施例中，(N’)y中5’末端的3个连续核苷酸是LNA核苷酸，(N’)y中3’末端的3个连续核苷酸通过2个2’-5磷酸二酯键连接。在(N)x中，核苷酸在修饰核糖核苷酸或未修饰核糖核苷酸这两个状态间交替变化，每个修饰核糖核苷酸的修饰是为了在糖基和未修饰(N)x的中间位置或未修饰(N)x的核糖核苷酸上具有2’-O-甲基。

在结构(C)的另一个实施例中，本发明提供一种化合物，其中x＝y＝19或x＝y＝23；在(N)x中，核苷酸在修饰核糖核苷酸或未修饰核糖核苷酸这两个状态间交替变化，每个修饰核糖核苷酸的修饰是为了在糖基和未修饰(N)x的中间位置的核糖核苷酸上具有2’-O-甲基；(N’)y中3’末端的修饰核苷酸通过2个2’-5磷酸二酯键连接，(N’)y中5’末端的3个核苷酸是LNA，如ENA。

在结构(C)的另一个实施例中，(N’)y中5’末端的5个连续核苷酸包括2’-O-甲基糖基修饰，(N’)y中3’末端的2个连续核苷酸是L-DNA。

在另一个实施例中，本发明提供一种化合物，其中x＝y＝19或x＝y＝23；(N)x是由未修饰核糖核苷酸组成；(N’)y中3’末端的3个连续核苷酸通过2个2’-5磷酸二酯键连接，(N’)y中5’末端的3个核苷酸是LNA，如ENA。

根据结构(C)的其他实施例，(N’)y中5’和3′末端的核苷酸或任何末端的2、3、4、5或6个连续核苷酸或每个5’和3′末端的1-4个修饰核苷酸是独立的膦酰基羧酸酯核苷酸或膦化羧酸酯核苷酸(PACE核苷酸)。在一些实施例中，PACE核苷酸是脱氧核糖核苷酸。在一些优选实施例中，(N’)y中每个5’和3′末端的1或2个连续核苷酸是PACE核苷酸。PACE核苷酸及类似物的实例在美国专利No.6,693,187和7,067,641中有所披露，在此全部以引用方式纳入。

在其他的实施例中，本发明提供一种具有结构(D)的化合物：

(D) 5’(N)_x-Z        3’反义链

    3’Z’-(N’)_y    5’正义链

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸，且每个X和Y是介于18至40的整数；；

其中，(N)x包括在3’末端或倒数第二位置进一步含有一个修饰核苷酸的未修饰核糖核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组；

其中，(N’)y包括在5’末端或倒数第二位置进一步包含有一个修饰核苷酸的未修饰核糖核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组；

其中，在每个(N)x和(N’)y中，修饰和未修饰的核苷酸是不交替的；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在任何低聚物的3’末端共价连接的话，其是存在的；以及

其中，(N’)y的序列是与(N)x大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在结构(D)的一个实施例中，x＝y＝19或x＝y＝23；(N)x包括3’末端的2个连续核苷酸通过一个2’-5’核苷酸间连键连接的未修饰核糖核苷酸；(N’)y包括5’末端的2个连续核苷酸通过一个2’-5’核苷酸间连键连接的未修饰核糖核苷酸。

在一些实施例中，x＝y＝19或x＝y＝23；(N)x包括3’末端的4个连续核苷酸通过3个2’-5’核苷酸间连键连接的未修饰核糖核苷酸；(N’)y包括5’末端的4个连续核苷酸是通过3个2’-5’磷酸二酯键(如此处结构II所述)连接的未修饰核糖核苷酸。

根据结构(D)的不同实施例，(N)x中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N’)y中5′末端的终端或倒数第二位置，并是通过2’-5’核苷酸间连键连接。

根据结构(D)的一个优选实施例，(N’)y中5’末端的4个连续核苷酸是通过3个2’-5’核苷酸间连键连接，(N’)x中3’末端的3个连续核苷酸是通过2个2’-5’核苷酸间连键连接。(N’)y中5’末端的3个核苷酸和(N’)x中3’末端的2个核苷酸也可包括3’-O-甲基修饰。

根据结构(D)的不同实施例，(N)x中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N’)y中5′末端的终端或倒数第二位置，是独立的镜像核苷酸。在一些实施例中，镜像核苷酸是L-核糖核苷酸。在其他实施例中，镜像核苷酸是L-脱氧核糖核苷酸。

在结构(D)的其他实施例中，在(N)x中，3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N’)y中5′末端的终端或倒数第二位置，是独立的2’糖基修饰核苷酸。在一些实施例中，2’糖基修饰包括氨基、氟代、烷氧基或烷基。在某些实施例中，2’糖基修饰包括甲氧基(2’-OMe)。

在结构(D)的一个优选实施例中，(N’)y中5’末端的5个连续核苷酸包括2’-O-甲基修饰。(N’)x中3’末端的5个连续核苷酸包括2’-O-甲基修饰。在结构(D)的另一个优选实施例中，(N’)y中5’末端的10个连续核苷酸包括2’-O-甲基修饰。(N’)x中3’末端的5个连续核苷酸包括2’-O-甲基修饰。在结构(D)的另一个优选实施例中，(N’)y中5’末端的13个连续核苷酸包括2’-O-甲基修饰。(N’)x中3’末端的5个连续核苷酸包括2’-O-甲基修饰。

在结构(D)的一些实施例中，(N’)y中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N)x中5′末端的终端或倒数第二位置，是独立的双环核苷酸。在不同实施例中，双环核苷酸是锁核酸(LNA)，如2′-O，4′-C-乙烯基-桥接核酸(ENA)。

在结构(D)的不同实施例中，(N’)y包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸；

在结构(D)的不同实施例中，(N)x包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸；

在实施例中，其中相同链的每个3’和5’末端包括修饰核苷酸，5’和3’末端的修饰是相同的。在另一个实施例中，5’末端的修饰不同于同样链的3’末端的修饰。在一个特定实施例中，5’末端的修饰核苷酸是镜像核苷酸，同样链的3’末端的修饰核苷酸是通过2’-5’磷酸二酯键连接。

在结构(D)的一个特定实施例中，(N’)y中5’末端的5个连续核苷酸包括2’-O-甲基修饰，(N’)y中3’末端的2个连续核苷酸是L-DNA。此外，该化合物还可包括(N’)x中3’末端的5个连续的2’-O-甲基修饰核苷酸。

在结构(D)的不同实施例中，(N)x中的修饰核苷酸不同于(N’)y中的修饰核苷酸。例如，(N)x中的修饰核苷酸是2’糖基修饰核苷酸，(N’)y中的修饰核苷酸是通过核酸间连键连接。在另一个实例中，(N)x中的修饰核苷酸是镜像核苷酸，(N’)y中的修饰核苷酸是通过核酸间连键连接。在另一个实例中，(N)x中的修饰核苷酸是通过核酸间连键连接，(N’)y中的修饰核苷酸是镜像核苷酸。

在其他的实施例中，本发明提供一种具有结构(E)的化合物：

(E)5’(N)_x-Z        3’反义链

   3’Z’-(N’)_y    5’正义链

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸，且每个X和Y是介于18至40的整数；

其中，(N)x包括在5’末端或倒数第二位置进一步包含有一个修饰核苷酸的未修饰核糖核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组；

其中，(N’)y包括在3’末端或倒数第二位置进一步包含有一个修饰核苷酸的未修饰核糖核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组；

其中，在每个(N)x和(N’)y中，修饰和未修饰的核苷酸是不交替的；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在任何低聚物的3’末端共价连接的话，其是存在的；以及

其中，(N’)y的序列是与(N)x大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核糖核苷酸大体互补的反义序列。

在某些优选实施例中，(N)x中5’末端的终端核苷酸是未修饰的。

根据结构(E)的不同实施例，(N)x中5′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N’)y中5′末端的终端或倒数第二位置，优选为起始于5′末端的倒数第二位置；起始于(N’)y中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸是通过2’-5’核酸间连键连接。

根据结构(E)的不同实施例，(N)x中5′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N’)y中5′末端的倒数第二位置；起始于(N’)y中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸是独立的镜像核苷酸。在一些实施例中，镜像核苷酸是L-核糖核苷酸。在其他实施例中，镜像核苷酸是L-脱氧核糖核苷酸。

在结构(E)的其他实施例中，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N)x中5′末端的终端或倒数第二位置，优选为起始于5′末端的倒数第二位置；起始于(N’)y中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸是2’糖基修饰核苷酸。在一些实施例中，2’糖基修饰包括氨基、氟代、烷氧基或烷基。在某些实施例中，2’糖基修饰包括甲氧基(2’-OMe)。

在结构(E)的一些实施例中，(N’)y中的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N)x中5′末端的终端或倒数第二位置，优选为起始于5′末端的倒数第二位置；起始于(N’)y中3′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸是独立的双环核苷酸。在不同实施例中，双环核苷酸是锁核酸(LNA)，如2′-O，4′-C-乙烯基-桥接核酸(ENA)。

在结构(E)的不同实施例中，(N’)y包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自3’末端或每个3’和5’末端的2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸。

在结构(E)的不同实施例中，(N)x包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自3’末端或每个3’和5’末端的2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸。

在一个实施例中，同样的链的3’和5’末端包括修饰核苷酸，5’和3’末端的修饰是相同的。在另一个实施例中，5’末端的修饰不同于同样的链的3’末端的修饰。在一特定实施例中，5’末端的修饰核苷酸是镜像核苷酸，同样的链的3’末端的修饰核苷酸是通过选自2’-5’磷酸二酯键连接。

在结构(E)的不同实施例中，(N)x中的修饰核苷酸不同于(N’)y中的修饰核苷酸。例如，(N)x中的修饰核苷酸是2’糖基修饰核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接。在另一个实例中，(N)x中的修饰核苷酸是镜像核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接。在另一个实例中，(N)x中的修饰核苷酸是通过2’-5’核酸间连键连接，(N’)y中的修饰核苷酸是镜像核苷酸。

在其他的实施例中，本发明提供一种具有结构(F)的化合物：

(F)5’(N)_x-Z    3’反义链

3’Z’-(N’)_y    5’正义链

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸，且每个X和Y是介于18至40的整数；

其中，每个(N)x和(N’)y包括未修饰核糖核苷酸，其中，每个(N)x和(N’)y独立地包括3’末端或倒数第二位置一个修饰核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸或或通过选自P-烷氧基骨架修饰与相邻核苷酸连接或通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸组成的组；

其中，在每个(N)x和(N’)y中，修饰和未修饰的核苷酸是不交替的；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在任何低聚物的3’末端共价连接的话，其是存在的；

其中，(N’)y的序列是与(N)x大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在结构(F)的一些实施例中，x＝y＝19或x＝y＝23；(N’)y包括未修饰核糖核苷酸，其中3’末端的2个连续核苷酸包括2个连续镜像脱氧核糖核苷酸；(N)x包括未修饰核糖核苷酸，其中3’末端的1个核苷酸包括1个镜像脱氧核糖核苷酸(如结构III所述)。

根据结构(F)的不同实施例，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸独立地起始于(N)x和(N’)y中3′位置的终端或倒数第二位置，是通过2’-5’核酸间连键连接。

根据结构(F)的一个优选实施例，(N’)y中3′末端的3个连续核苷酸是通过2个2’-5’磷酸二酯键键连接，(N’)x中3′末端的3个连续核苷酸是通过2个2’-5’磷酸二酯键键连接。

根据结构(F)的不同实施例，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核苷酸独立地起始于(N)x和(N’)y中3′末端的终端或倒数第二位置，是独立的镜像核苷酸。在一些实施例中，镜像核苷酸是L-核糖核苷酸。在其他实施例中，镜像核苷酸是L-脱氧核糖核苷酸。

在结构(F)的其他实施例中，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N)x和(N’)y中3′末端的终端或倒数第二位置，是独立的2’糖基修饰核苷酸。在一些实施例中，2’糖基修饰包括氨基、氟代、烷氧基或烷基。在某些实施例中，2’糖基修饰包括甲氧基(2’-OMe)。

在结构(F)的一些实施例中，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸独立地起始于(N)x和(N’)y中3′末端的终端或倒数第二位置，是独立的双环核苷酸。在不同实施例中，双环核苷酸是锁核酸(LNA)，如2′-O，4′-C-乙烯基-桥接核酸(ENA)。

在结构(F)的不同实施例中，(N’)y包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自3’末端或每个3’和5’末端的2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸。

在结构(F)的不同实施例中，(N)x包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自3’末端或每个3’和5’末端的2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸。

在一个实施例中，同样的链的3’和5’末端包括修饰核苷酸，5’和3’末端的修饰是相同的。在另一个实施例中，5’末端的修饰不同于同样的链的3’末端的修饰。在一特定实施例中，5’末端的修饰核苷酸是镜像核苷酸，同样的链的3’末端的修饰核苷酸是通过选自2’-5’磷酸二酯键连接。

在结构(F)的不同实施例中，(N)x中的修饰核苷酸不同于(N’)y中的修饰核苷酸。例如，(N)x中的修饰核苷酸是2’糖基修饰核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸。在另一个实例中，(N)x中的修饰核苷酸是镜像核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸。在另一个实例中，(N)x中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸，(N’)y中的修饰核苷酸是镜像核苷酸。

在其他的实施例中，本发明提供一种具有结构(G)的化合物：

5’(N)_x-Z        3’反义链

3’Z’-(N’)_y    5’正义链

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸，且每个X和Y是介于18至40的整数；

其中，每个(N)x和(N’)y包括未修饰核糖核苷酸，每个(N)x和(N’)y独立地包括3’末端或倒数第二位置一个修饰核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸或或通过选自P-烷氧基骨架修饰与相邻核苷酸连接或通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸组成的组；

其中，对(N)x来说，修饰核苷酸优选为在5’末端的倒数第二；

其中，在每个(N)x和(N’)y中，修饰和未修饰的核苷酸是不交替的；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在任何低聚物的3’末端共价连接的话，其是存在的；以及

其中，(N’)y的序列是与(N)x大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在结构(G)的一些实施例中，x＝y＝19。

根据结构(G)的不同实施例，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸独立地起始于(N)x和(N’)y中5′末端的终端或倒数第二位置，是通过2’-5’核酸间连键连接。对(N)x来说，修饰核苷酸优选为起始于5′末端的倒数第二位置。

根据结构(G)的不同实施例，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核苷酸独立地起始于(N)x和(N’)y中3′末端的终端或倒数第二位置，是独立的镜像核苷酸。在一些实施例中，镜像核苷酸是L-核糖核苷酸。在其他实施例中，镜像核苷酸是L-脱氧核糖核苷酸。对(N)x来说，修饰核苷酸优选为起始于5′末端的倒数第二位置。

在结构(G)的其他实施例中，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N)x和(N’)y中5′末端的终端或倒数第二位置，是独立的2’糖基修饰核苷酸。在一些实施例中，2’糖基修饰包括氨基、氟代、烷氧基或烷基。在某些实施例中，2’糖基修饰包括甲氧基(2’-OMe)。在一些实施例中，连续修饰核苷酸优选为起始于(N)x中5′末端的倒数第二位置。

在结构(G)的一个优选实施例中，(N’)y中5’末端的5个连续核糖核苷酸包括2’-O-甲基修饰，(N’)x中5’倒数第二位置的一个核糖核苷酸包括2’-O-甲基修饰。在结构(G)的另一个优选实施例中，(N’)y中5’末端的5个连续核糖核苷酸包括2’-O-甲基修饰，N’)x中5’末端的2个连续核糖核苷酸包括2’-O-甲基修饰。

在结构(G)的一些实施例中，2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸起始于(N)x和(N’)y中5′末端的终端或倒数第二位置，是双环核苷酸。在不同实施例中，双环核苷酸是锁核酸(LNA)，如2′-O，4′-C-乙烯基-桥接核酸(ENA)。在一些优选实施例中，连续修饰核苷酸优选为起始于(N)x中5′末端的倒数第二位置。

在结构(G)的不同实施例中，(N’)y包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自3’末端或每个3’和5’末端的2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸。

在结构(G)的不同实施例中，(N)x包括选自双环核苷酸、2’-糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过选自3’末端或每个3’和5’末端的2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸的修饰核苷酸。

在一个实施例中，同样的链的3’和5’末端包括修饰核苷酸，5’和3’末端的修饰是相同的。在另一个实施例中，5’末端的修饰不同于同样的链的3’末端的修饰。在一特定实施例中，5’末端的修饰核苷酸是镜像核苷酸，同样的链的3’末端的修饰核苷酸是通过选自2’-5’磷酸二酯键连接。在结构(G)的不同实施例中，(N)x中的修饰核苷酸不同于(N’)y中的修饰核苷酸。例如，(N)x中的修饰核苷酸是2’糖基修饰核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸。在另一个实例中，(N)x中的修饰核苷酸是镜像核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸。在另一个实例中，(N)x中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸，(N’)y中的修饰核苷酸是镜像核苷酸。

在其他的实施例中，本发明提供一种具有结构(H)的化合物：

(H)5’(N)_x-Z        3’反义链

   3’Z’-(N’)_y    5’正义链

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸，且每个X和Y是介于18至40的整数；

其中，(N)x包括在3’末端或倒数或者5’末端或倒数或第二位置进一步包含有一个修饰核苷酸的未修饰核糖核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组；

其中，(N’)y包括在内部位点进一步包含有一个修饰核苷酸的未修饰核糖核苷酸，其中，修饰核苷酸是选自由双环核苷酸、2’糖基修饰核苷酸、镜像核苷酸、阿卓糖醇核苷酸或或通过选自2’-5’磷酸二酯键、P-烷氧基连键或PACE连键的核苷酸间连键与相邻核苷酸连接的核苷酸组成的组；

其中，在每个(N)x和(N’)y中，修饰和未修饰的核苷酸是不交替的；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在任何低聚物的3’末端共价连接的话，其是存在的；

其中，(N’)y的序列是与(N)x大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在结构(H)的一个实施例中，独立地起始于(N)x中3′末端或者5′末端的终端或倒数第二位置或者两个末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸是独立的2’糖基修饰核苷酸、双环核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸。(N’)y中2、3、4、5、6、7、8、9、10、11、12、13或14个连续内部核糖核苷酸是独立的2’糖基修饰核苷酸、双环核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸。在一些实施例中，2’糖基修饰包括氨基、氟代、烷氧基或烷基。在某些实施例中，2’糖基修饰包括甲氧基(2’-OMe)。

在结构(H)的另一个实施例中，独立地起始于3′末端或者5′末端的终端或倒数第二位置的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核糖核苷酸或(N’)y中每个5’和3’末端的2-8个连续核苷酸是独立的2’糖基修饰核苷酸、双环核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸。(N)x中2、3、4、5、6、7、8、9、10、11、12、13或14个连续内部核糖核苷酸是独立的2’糖基修饰核苷酸、双环核苷酸、镜像核苷酸、阿卓糖醇核苷酸或通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸。

在一个实施例中，同样的链的3’和5’末端包括修饰核苷酸，5’和3’末端的修饰是相同的。在另一个实施例中，5’末端的修饰不同于同样的链的3’末端的修饰。在一特定实施例中，5’末端的修饰核苷酸是镜像核苷酸，同样的链的3’末端的修饰核苷酸是通过选自2’-5’磷酸二酯键连接。

在结构(H)的不同实施例中，(N)x中的修饰核苷酸不同于(N’)y中的修饰核苷酸。例如，(N)x中的修饰核苷酸是2’糖基修饰核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸。在另一个实例中，(N)x中的修饰核苷酸是镜像核苷酸，(N’)y中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸。在另一个实例中，(N)x中的修饰核苷酸是通过2’-5’核酸间连键连接的核苷酸，(N’)y中的修饰核苷酸是镜像核苷酸。

在结构((H)的一个优选实施例中，x＝y＝19；(N’)y中核苷酸位点9-11的3个连续核糖核苷酸包括2’-O-甲基修饰，(N’)x中3’末端的5个连续核糖核苷酸包括2’-O-甲基修饰。

一方面，本发明提供一种如下结构(I)所述的化合物：

(I)5’(N)_x-Z         3’(反义链)

   3’Z’-(N’)_y-z” 5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′可能是存在或不存在的，但如果存在1-5个连续核苷酸的链在任何低聚物的3’末端共价连接的话，其是存在的；以及

其中，z”可能是存在或不存在的，但如果帽端基团在(N’)y的5’末端共价连接的话，其是存在的；

其中x＝18至27；

其中y＝18至27；

其中，(N)x包括修饰和未修饰核糖核苷酸，每个修饰核糖核苷酸在其糖基上具有2’-O-甲基，其中(N)x中3’末端的N是修饰核糖核苷酸，(N)x包括至少5个起始于3’末端的交替修饰核糖核苷酸，且总共至少9个修饰核糖核苷酸。每个剩余的N是未修饰核糖核苷酸；

其中，(N’)y中至少一个非常规基团是存在的，其中非常规基团可能是脱碱基核糖基、脱碱基脱氧核糖基、修饰或未修饰脱氧核糖核苷酸、镜像核苷酸以及通过2’-5’磷酸二酯键与相邻核苷酸连接的核苷酸；以及

其中，(N’)y的序列是与(N)x大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在一些实施例中，x＝y＝19。在其他实施例中，x＝y＝23。在一些实施例中，至少一个非常规基团存在于(N’)y的位点15、16、17或18。在一些实施例中，非常规基团是选自镜像核苷酸、脱碱基核糖基和脱碱基脱氧核糖基。在一些优选实施例中，非常规基团是镜像核苷酸，优选为L-DNA基。在一些实施例中，L-DNA基存在于位点17、位点18或位点17和位点18。

在其他实施例中，非常规基团是脱碱基。在不同实施例中，(N’)y包括至少5个脱碱基核糖基或脱碱基脱氧核糖基。

在其他实施例中，(N’)y包括至少5个脱碱基核糖基或脱碱基脱氧核糖基，且至少一个N’是LNA。

在(I)的一些实施例中，(N)x包括9个交替修饰核糖核苷酸。在(I)的一些实施例中，(N)x包括在位点2进一步包含2’O修饰核苷酸的9个交替修饰核糖核苷酸。在一些实施例中，(N)x包括在奇数位点1、3、5、7、9、11、13、15、17、19的2’-OMe糖基修饰核糖核苷酸。在其他实施例中，(N)x还包括在位点2和18的2’-OMe糖基修饰核糖核苷酸。

在其他实施例中，(N’)y包括在位点2、4、6、8、11、13、15、17、19的2’-OMe糖基修饰核糖核苷酸。

在不同实施例中，z”是存在的，且是选自脱碱基核糖基、脱氧核糖基；反向脱碱基核糖基、脱氧核糖基；C6-氨基-Pi；镜像核苷酸。

另一方面，本发明提供一种如下结构(J)所述的化合物：

(J)5’(N)_x-Z          3’(反义链)

   3’Z’-(N’)_y-z”  5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′可能是存在或不存在的，但如果独立的1-5个连续核苷酸与链的3’末端共价连接的话，其是存在的；

其中，z”可能是存在或不存在的，但如果帽端基团与(N’)y的5’末端共价连接的话，其是存在的；

其中x＝18至27；

其中y＝18至27；

其中，(N)x包括修饰或未修饰核糖核苷酸，以及可选择性地至少一种非常规基团；

其中，(N’)y中至少一个非常规基团是存在的，其中非常规基团可能是脱碱基核糖基、脱碱基脱氧核糖基、修饰或未修饰脱氧核糖核苷酸、镜像核苷酸、非碱基配对核苷酸类似物或通过2’-5’核酸间磷酸键与相邻核苷酸连接的核苷酸；以及

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在一些实施例中，x＝y＝19。在其他实施例中，x＝y＝23。在一些优选实施例中，(N)x包括修饰和未修饰核糖核苷酸，以及至少一种非常规基团。

在一些实施例中，(N)x中3′末端的N是修饰核糖核苷酸，(N)x包括至少8种修饰核糖核苷酸。在其他实施例中，至少8种修饰核糖核苷酸的至少5种交替起始于3′末端。在一些实施例中，(N)x包括在位点5、6、7、8、9、10、11、12、13、14或15之一的脱碱基。

在一些实施例中，(N’)y中的至少一种非常规基团存在于位点15、16、17或18。在一些实施例中，非常规基团是选自镜像核苷酸、脱碱基核糖基和脱碱基脱氧核糖基。在一些优选实施例中，非常规基团是镜像核苷酸，优选为L-DNA基。在一些实施例中，L-DNA基存在于位点17、位点18或位点17和位点18。在其他实施例中，(N’)y中的至少一种非常规基团是脱碱基核糖基和脱碱基脱氧核糖基。

在结构(X)的不同实施例中，z”是存在的，且是选自脱碱基核糖基、脱氧核糖基；反向脱碱基核糖基、脱氧核糖基；C6-氨基-Pi；镜像核苷酸。

在另一方面，本发明提供一种具有如下结构(K)的化合物：

(K)5’(N)_x-Z         3’(反义链)

   3’Z’-(N’)_y-z” 5’(正义链)

其中，每个N和N’可能是未修饰或修饰核糖核苷酸，或非常规基团；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′可能是存在或不存在的，但如果与独立的1-5个连续核苷酸与链的3’末端共价连接的话，其是存在的；

其中，z”可能是存在或不存在的，但如果帽端基与(N’)y的5’末端共价连接的话，其是存在的；

其中x＝18至27；

其中y＝18至27；

其中(N)x包括修饰或未修饰核糖核苷酸、非常规基团以及在糖基上具有2’-O-甲基的任何修饰核糖核苷酸的组合；

其中(N)x包括修饰或未修饰核糖核苷酸以及可选择性地一种非常规基团，在糖基上具有2’OMe的任何修饰核糖核苷酸；

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列；其中具有与mRNA互补的不超过15个连续核苷酸。

在一些实施例中，x＝y＝19。在其他实施例中，x＝y＝23。在一些优选实施例中，至少一个非常规基团存在于(N)x中，且是脱碱基核糖基和脱碱基脱氧核糖基。在其他实施例中，至少一个非常规基团存在于(N)x中，且是非碱基配对核苷酸类似物，在不同实施例中，(N’)y包括未修饰核糖核苷酸。在一些实施例中，(N)x包括至少5种脱碱基核糖基或脱碱基脱氧核糖基或其组合。在某些实施例中，(N)x和/或(N’)y包括修饰核糖核苷酸，并不与(N’)y和/或(N)x中相应的修饰或未修饰核糖核苷酸发生碱基配对。

在不同实施例中，本发明提供一种如结构(L)所示的siRNA：

(L) 5’(N)_x-Z        3’(反义链)

    3’Z’-(N’)_y    5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′可能是存在的；

其中x＝19；

其中，在(N’)y中，15、16、17、18和19中至少一个位点的核苷酸包括选自脱碱基假核苷酸、镜像核苷酸、脱氧核糖核苷酸以及通过2’-5’核酸间键与相邻核苷酸连接的核苷酸；

其中，(N)x包括交替修饰核糖核苷酸和未修饰核糖核苷酸，每个被修饰的核糖核苷酸是为了在其糖基上具有2’-O-甲基。(N)x中间位置是修饰或未修饰的，优选为未修饰的；以及

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在(L)的一些实施例中，(N’)y中位点17和18中的一个或两个包括选自脱碱基假核苷酸、镜像核苷酸以及通过2’-5’核酸间键与相邻核苷酸连接的核苷酸。在一些实施例中，镜像核苷酸是选自L-DNA和L-RNA。在不同实施例中，镜像核苷酸是L-DNA。

在不同实施例中，(N’)y包括在位点15的修饰核苷酸，其中修饰核苷酸是选自镜像核苷酸和脱氧核糖核苷酸。

在某些实施例中，(N’)y还包括在位点2的修饰核苷酸或假核苷酸，其中假核苷酸可能是脱碱基假核苷酸类似物，修饰核苷酸是可选的镜像核苷酸。

在不同实施例中，反义链(N)x包括在奇数位点(5’至3’)的2’O-Me修饰核糖核苷酸；位点1、3、5、7、9、11、13、15、17、19)。在一些实施例中，(N)x还包括在位点2和18中的一个或两个的2’O-Me修饰核糖核苷酸。在其他实施例中，(N’)y包括在位点2、4、6、8、11、13、15、17、19的2’-OMe糖基修饰核糖核苷酸。

结构(L)、(I)和(J)的其他实施例是设想的，其中x＝y＝21或其中x＝y＝23；在这些实施例中，上文讨论的(N’)y修饰中，对于21个碱基的寡核苷酸，修饰位点分别为19、20，而不是17和18；对于23个碱基长度的寡核苷酸，修饰位点分别为21、22，而不是17和18。同样地，对于21个碱基长度的寡核苷酸，修饰位点是17、18、19、20或21，而不是15、16、17、18或19；对于23个碱基长度的寡核苷酸，修饰位点是19、20、21、22或23，而不是15、16、17、18或19。反义链上的2’-OMe修饰是同样调整的。在一些实施例中，(N)x包括在奇数位点(5’至3’；对于21个碱基长度的寡核苷酸[未修饰的位点11的核苷酸])，修饰位点为1、3、5、7、9、12、14、16、18、20；对于23个碱基长度的寡核苷酸[未修饰的位点12的核苷酸]，修饰位点为1、3、5、7、9、11、13、15、17、19、21、23)的2’-OMe糖基修饰核糖核苷酸。在其他实施例中，(N)x包括修饰位点为2、4、6、8、10、12、14、16、18、20的2’-OMe糖基修饰核糖核苷酸[对于21个碱基的寡核苷酸，位点11的核苷酸未修饰；对于23个碱基的寡核苷酸，修饰位点为2、4、6、8、10、13、15、17、19、21、23[位点12的核苷酸未修饰]]。

在一些实施例中，(N’)y还包括5’末端帽核苷酸。在不同实施例中，末端帽基是选自脱碱基假核苷酸类似物、反向脱碱基假核苷酸类似物、L-DNA核苷酸和C6-亚胺基磷酸酯(C6氨基在末端与磷酸酯连接键)。

在其他实施例中，本发明提供一种如下结构(M)所示的化合物：

5’(N)_x-Z        3’(反义链)

3’Z’-(N’)_y    5’(正义链)

其中，每个N和N’是选自假核苷酸和核苷酸；

其中，每个核苷酸是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸和修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′是存在的；

其中x＝18至27；

其中y＝18至27；

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列；

其中至少一个N是选自脱碱基假核苷酸、非配对核苷酸类似物和(N)x中目标基因的mRNA错配的核苷酸，以使得(N)x包括与目标基因的mRNA互补的不超过15个连续核苷酸。

在其他实施例中，本发明提供一种具有如结构(N)所示的双链化合物：

(N)5’(N)_x-Z        3’(反义链)

   3’Z’-(N’)_y    5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′是存在的；

其中，每个X和Y是介于18至40的整数；

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

其中，(N)x、(N’)y或(N)x和(N’)y包括非碱基配对修饰核苷酸，以使得(N)x和(N’)y在双链化合物中形成不超过15个碱基对。

在其他实施例中，本发明提供一种具有如下结构(O)所述的化合物：

(O) 5’(N)_x-Z        3’(反义链)

    3’Z’-(N’)_y    5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个N’是选自6元环糖基核苷酸、7元环糖基核苷酸、吗啉代基、肽核酸或其组合的核苷酸类似物；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′是存在的；

其中每个x和y是介于18至40的整数；

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在其他实施例中，本发明提供一种具有如下结构(P)所述的化合物：

(P)5’(N)_x-Z        3’(反义链)

   3’Z’-(N’)_y    5’(正义链)

其中，每个N和N’是选自未修饰核糖核苷酸、修饰核糖核苷酸、未修饰脱氧核糖核苷酸或修饰脱氧核糖核苷酸的核苷酸；

其中，每个(N)x和(N’)y是每个连续的N或N’通过共价键连接到下一个N或N’的寡核苷酸；

其中，Z和Z′是存在的；

其中每个x和y是介于18至40的整数；

其中，(N)x或(N’)y内部位点的一个N或N’或者(N)x或(N’)y末端位点的一个或多个N或N’包括脱碱基或2’修饰核苷酸；

其中，(N)x的序列是与(N’)y大体互补的序列；其中(N)x的序列包括与任一SEQ ID NO：1-58所述mRNA中约18至约40个连续核苷酸大体互补的反义序列。

在不同实施例中，(N’)y包括在位点15的修饰核苷酸，其中修饰核苷酸是选自镜像核苷酸和脱氧核糖核苷酸。

在某些实施例中，(N’)y还包括在位点2的修饰核苷酸，其中修饰核苷酸是选自镜像核苷酸和脱碱基假核苷酸类似物。

在不同实施例中，(N)x的反义链包括在奇数位点(5’至3’；位点1、3、5、7、9、11、13、15、17、19)的2’-OMe修饰核糖核苷酸。在一些实施例中，

(N)x还包括在位点2和18中的一个或两个的2’-OMe修饰核糖核苷酸。在其他实施例中，N)x包括在位点2、4、6、8、11、13、15、17、19的2’-OMe修饰核糖核苷酸。

上述的(A)-(P)的结构序列用于哺乳动物或非哺乳动物基因的任何寡核苷酸配对(正义和反义链)。在一些实施例中，哺乳动物基因是优选自表A1-A4中提供如SEQ ID NO：1-58所述mRNA的基因的人类基因。在某些优选实施例中，siRNA的正义和反义寡核苷酸是选自如SEQ ID NO：59-33，596所述的任一siRNA对。以下表A5显示了某些优选的正义和反义寡核苷酸对。

表A5

目标基因	正义链(N’)y 5’-3’	反义链(N)x  5’-3’
			P53	GAGAAUAUUUCACCCUUCA	UGAAGGGUGAAAUAUUCUC
CASP2	GCCAGAAUGUGGAACUCCU	AGGAGUUCCACAUUCUGGC
			RTP801	GUGCCAACCUGAUGCAGCU	AGCAGCAUCAGGUUGGCAC
RTP801	UACUGUAGCAUGAAACAAA	UUUGUUUCAUGCUACAGUA
			RTP801	CAGUACUGUAGCAUGAAAC	GUUUCAUGCUACAGUACUG
TP53BP2	CACCCAGAGAACAUUUAUU	AAUAAAUGUUCUCUGGGUG
			CYBA	UGGGGACAGAAGUACAUGA	UCAUGUACUUCUGUCCCCA
RAC1	GAGUCCUGCAUCAUUUGAA	UUCAAAUGAUGCAGGACUC

SPP1	GUGCCAUACCAGUUAAACA	UGUUUAACUGGUAUGGCAC
			SPP1	GCAAAAUGAAAGAGAACAU	AUGUUCUCUUUCAUUUUGC
ASPP1	CGAACUCAGAGAAAUGUAA	UUACAUUUCUCUGAGUUCG
			ASPP1	GGAGAAAAACGUACUGAAA	UUUCAGUACGUUUUUCUCC
SOX9	CCUUCAUGAAGAUGACCGA	UCGGUCAUCUUCAUGAAGG

所有的上述结构(A)-(P)，在不同实施例中，x＝y，每个x和y是19、20、21、22或23。在优选实施例中，x＝y＝19。在其他实施例中，化合物包括在交替位置的修饰核糖核苷酸，其中(N)x中5’和3’末端的每个N在其糖残基上是修饰的，中间的核糖核苷酸是未修饰的，例如，19个碱基链的位点10、21个碱基链的位点11以及23个碱基链的位点12的核糖核苷酸。

在一些实施例中，其中x＝y＝19或x＝y＝23。19个碱基的修饰位点被调整为21个碱基和23个碱基，其附带条件是反义链的中间核苷酸优选为不被修饰。

所有的上述结构(A)-(P)，在一些实施例中，(N)x和(N’)y在3’和5’末端都是非磷酸化的。在其他实施例中，(N)x和(N’)y的一个或两个在3’末端是磷酸化的。在另一个实施例中，(N)x和(N’)y的一个或两个在3’末端采用非剪切磷酸基使其磷酸化。在另一个实施例中，(N)x和(N’)y的一个或两个在末端2’末端位点采用剪切或非剪切磷酸基使其磷酸化。这些特定的siRNA化合物也是钝端的，且在末端是非磷酸化的；然而，比较实验已显示3’末端的一个或两个磷酸化的siRNA化合物在体内与非磷酸化合物具有相似的活性。

所有的上述结构(A)-(P)，在一些实施例中，该化合物是钝端的，例如，其中Z和Z’是不存在的。在一个交替的实施例中，该化合物包括至少3个悬突，其中至少一个Z或Z’是存在的。Z和Z’独立地包括一个或多个共价连接修饰或未修饰的核苷酸，例如，反向dT或dA；dT、LNA、镜像核苷酸等。在一些实施例中，每个Z和Z’是独立地选自dT和dTdT。Z和/或Z’存在时的siRNA具有与Z和/或Z’不存在时相似的活性和稳定性。

在所有上述结构的某些实施例中，该化合物包括一个或多个锁核酸(LNA)，也可定义为桥接核酸或双环核酸。优选的锁核酸是2′-O，4′-C-乙烯基核酸(ENA)或2′-O，4′-C-亚甲基核酸。LNA和ENA核酸的其他实例在WO 98/39352、WO 00/47599和WO 99/14226中有所披露，在此全部以引用方式纳入。

在所有上述结构的某些实施例中，该化合物包括一个或多个阿卓糖醇单体(核苷酸)，也解释为1，5脱水-2-脱氧-D-阿卓糖醇-己糖醇(见，例如，Allart，et al.，1998.Nucleosides & Nucleotides17：1523-1526；Herdewijn et al.，1999.Nucleosides & Nucleotides18：1371-1376；Fisher et al.，2007，NAR 35(4)：1064-1074；在此全部以引用方式纳入)。

本发明明确地包括每个N和或N’是脱氧核糖核苷酸(D-A、D-C、D-G、D-T)的化合物。在某些实施例中，(N)x和(N’)y可能独立地包括1、2、3、4、5、6、7、8或9个脱氧核糖核苷酸。在某些实施例中，本发明提供一种每个N是未修饰核糖核苷酸的化合物；3’末端核苷酸或(N’)y中3’末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核苷酸是脱氧核糖核苷酸。在其他的实施例中，每个N是未修饰核糖核苷酸；5’末端核苷酸或(N’)y中5’末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核苷酸是脱氧核糖核苷酸。在其他的实施例中，5’末端核苷酸或(N’)y中5’末端的2、3、4、5、6、7、8或9个连续核苷酸以及(N)x 3’末端的1、2、3、4、5、6个连续核苷酸是脱氧核糖核苷酸；每个N’是未修饰核糖核苷酸。在其他的实施例中，(N)x包括未修饰核糖核苷酸和每个5’和3’末端独立的1、2、3或4个连续脱氧核糖核苷酸以及内部位点的1、2、3、4、5或6个连续脱氧核糖核苷酸；每个N’是未修饰核糖核苷酸。在某些实施例中，3’末端核苷酸或(N’)y中3’末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核苷酸以及或(N)x中5’末端的2、3、4、5、6、7、8、9、10、11、12、13或14个连续核苷酸是脱氧核糖核苷酸。本发明不包括每个N和或N’是脱氧核糖核苷酸的化合物。在一些实施例中，N中的5’末端核苷酸或N中的2或3个连续核苷酸或N’中的1、2或3个连续核苷酸是脱氧核糖核苷酸。活性DNA/RNAsiRNA嵌合体的某些实例在美国专利2005/0004064和Ui-Tei，2008(NAR 36(7)：2136-2151)中有所披露，在此以全文引用方式纳入。

除非另有说明，此处所述结构的优选实施例，每个连续N和N′之间的共价键是磷酸二酯键。

本发明提供的另外一个新分子是包括连续核苷酸的寡核苷酸，其中这些核苷酸的第一段编码第一抑制RNA分子，这些核苷酸的第二段编码第二抑RNA分子，而这些核苷酸的第三段编码第三抑制RNA分子。第一、第二和第三段中的每个可包括双链RNA的一条链，第一、第二和第三段可通过连接键结合在一起。此外，寡核苷酸可包括通过一个或多个连接键结合在一起的三个双链段。

因此，本发明提供的一种分子是包括编码3个抑制RNA分子的连续核苷酸的寡核苷酸；所述寡核苷酸可能具有一个三链结构，使得3个双链臂通过一个或多个连接键连接在一起，例如，此处上述的任何一个连接键。这种分子形成了一个“星”型结构，此处也可称为RNAstar。这种结构在PCT专利申请WO 2007/091269中有所披露，被分配给本发明的受托人，在此以全文引用方式纳入。

共价键指的是一种连接一个核苷酸单体和其相邻核苷酸单体的核苷酸间连接键。共价键包括(例如)磷酸二酯键、硫代磷酸键、P-烷氧基键、P-羧基键等。RNA和DNA的正常核苷酸间连接键是3′-5′磷酸二酯键。在某些优选实施例中，共价键是磷酸二酯键。共价键包括非磷核苷酸间连接键，特别如WO 2004/041924所披露。除非另有说明，在此处所述结构的优选实施例中，每个连续N和N′之间的共价键是磷酸二酯键。

所有上述结构，在一些实施例中，(N)x的寡核苷酸序列与(N′)y的寡核苷酸序列是完全互补的。在其他实施例中，(N)x和(N’)y是大体互补的。在某些实施例中，(N)x与目标序列是完全互补的。在其他实施例中，(N)x与目标序列是大体互补的。

在一些实施例中，(N)x或(N’)y在3’和5’末端都是非磷酸化的。在其他实施例中，(N)x和(N’)y中的一个或两个在3’末端(3′Pi)是磷酸化的。在另一个实施例中，(N)x和(N’)y中的一个或两个在含有非剪切磷酸基的3’末端是磷酸化的。在另一个实施例中，(N)x和(N’)y中的一个或两个在含有剪切或非剪切磷酸基的2’末端是磷酸化的。此外，本发明的抑制核酸分子可包括一个或多个缺口和/或一个或多个裂口一个和/或多个错配。不希望受理论束缚，缺口、裂口和错配由于处于使核酸/siRNA部分动摇的优势，因此更可能通过内生的细胞机器如DROSHA或RISC加工成抑制成分。

在本发明的背景下，核酸的缺口指的是一条链缺乏一个或多个内部核苷酸，而核酸的裂口指的是一条链缺乏两个相邻核苷酸之间的核苷酸间连键。本发明的任何分子可包括一个或多个缺口和/或一个或多个裂口。

此处披露的结构，当被并入反义链和任何目标基因相应的正义核酸序列后，其提供了用于降低目标基因表达的siRNA化合物。该目标基因是哺乳动物或非哺乳动物基因。本发明的方法包括局部无创伤性地向受试者眼睛施用一种或多种siRNA化合物，所述siRNA化合物降低目标基因在受试者眼睛中的表达。

siRNA合成

本发明的化合物可通过核糖核酸(或脱氧核糖核酸)寡核苷酸技术领域公知的任何方法合成。这种合成，除了别的之外，在Beaucageand Iyer，Tetrahedron 1992；48：2223-2311；Beaucage and Iyer，Tetrahedron 1993；49：6123-6194and Caruthers，et.al.，MethodsEnzymol.1987；154：287-313中有所描述；thioates的合成，除了别的之外，在Eckstein，Annu.Rev.Biochem.1985；54：367-402中有所描述，RNA分子的合成在Herdewijn P.编辑的Sproat，in Humana Press2005中有所描述；代表性的下游方法，除了别的之外，在Oliver编辑的Pingoud et.al.，in IRL Press 1989中有所描述；Kap.7：183-208。

所属领域已知的其他合成方法，例如，该方法在Usman et al.，J.Am.Chem.Soc.，1987，109：7845；Scaringe et al.，NAR，1990，18：5433；Wincott et al.，NAR 1995，.23：2677-2684；以及Wincott et al.，MethodsMol.Bio.，1997，74：59中有所描述。这些方法可充分利用普通核酸保护和连接基团，如5′末端的二甲氧基三苯甲基和3′末端的亚磷酰胺。修饰(如2′-O-甲基化)核苷酸和未修饰核苷酸根据需要纳入。

本发明的寡核苷酸可通过分别地合成以及后合成结合在一起，例如，通过连接反应(Moore et al.，Science 1992，256：9923；国际专利公开No.WO 93/23569；Shabarova et al.，NAR 1991，19：4247；Bellon etal.，Nucleosides & Nucleotides，1997，16：951；Bellon  et al.，Bioconjugate Chem 1997，8：204)，或者根据合成和/或脱保护杂交。

据指出，市售的机器(可用，特别是得自Applied Biosystems))可以使用；寡核苷酸根据此处披露的序列制得。化学合成片段的重叠对可使用所属领域已知的方法结扎(例如，见美国专利No.6,121,426)。先分别地合成链，然后在真空管中对其退火。然后，通过高效液相色谱法分离双链siRNA与不退火的单链寡核苷酸(例如，因为其中之一过量)。相对于本发明的siRNAs或siRNA片段，两个或多个这样的序列可以合成和连接在一起用于本发明。

本发明的化合物也可通过串联合成方法合成，例如美国专利申请No.2004/0019001(McSwiggen)和PCT专利申请No.WO 2007/091269(分配给本发明的受托人，并以全文引用方式纳入)中所述，其中两个siRNA链被合成为通过裂解键分离的一个单一的连续寡核苷酸片段或链，之后裂解为能杂交并允许siRNA双链纯化的单独siRNA片段或链。连接键可以是一个多核苷酸连接键或非核苷酸连接键。

本发明还提供一种用于治疗任何此处提及的任何疾病和病症的包括两个或多个siRNA分子的药物组合物，从而所述两个分子以一定量在药物组合物中物理混合在一起，产生相同或相反的有益活性，或者可能是共价或非共价键结合，或通过长度范围为2-100的核酸连接键连接，优选为2-50或2-30个核苷酸。

因此，siRNA分子可能是共价键或非共价键结合，或通过键连接，以形成一个串联siRNA化合物。包括两个siRNA序列的这些串联siRNA化合物通常为约38-150个核苷酸长，较优选为38或40-60个核苷酸长，并相应地延长，如果超过两个siRNA序列被包括在串联分子中。包括两个或多个较长序列的较长串联化合物通过细胞内加工编码siRNA的序列，如长dsRNA也是设想为编码两个或多个shRNA的串联分子。这种串联分子也被认为是本发明的一部分。包括本发明的两个或多个siRNA序列的串联化合物是设想的。

此外，此处披露的siRNA或包括或编码这种siRNA的任何核酸分子可以连接或键合(共价或非共价)到目标细胞中表达的细胞表面内生分子的抗体(包括aptaMer分子)上，以达到加强对此处所披露疾病的目标治疗。例如，抗Fas抗体(优选为中和抗体)可与任何siRNA化合物结合(共价或非共价)。

本发明的化合物可以直接或与病毒或非病毒载体传输。当直接传输时，序列一般都呈现抗核酸酶性。另外，序列可以被包含入表达试剂盒或结构，使得该序列在本文以下所讨论的细胞中表达。一般来说，该结构包含适当的调控序列或启动子，以允许该序列在目标细胞中表达。任选地用于本发明化合物传输的载体是市售的，并可修饰以用于所属技术领域公知的方法传输本发明化合物。

还设想，包括一个或多个茎环结构的一种长寡核苷酸(通常25-500个核苷酸长)，其中茎区域包括本发明的寡核苷酸序列，可通过载体传输，优选为药学上可接受的载体，也可通过内生细胞复合物(如上面DROSHA和DICER所述)进行胞内加工，以产生本发明寡核苷酸的一个或多个较小的双链寡核苷酸(siRNA)。这种寡核苷酸可以被称为串联shRNA结构。据设想，这种长寡核苷酸是括一个或多个茎环结构的一种单链寡核苷酸，其中每个茎区域包括本发明基因的一个正义及相应的反义siRNA序列。

RNA干扰

最近已发表许多与RNAi现象有关的PCT申请。这些包括：PCT公布WO 00/44895；PCT公布WO 00/49035；PCT公布WO 00/63364；PCT WO 01/36641；PCT公布WO 01/36646；PCT公布WO 99/32619；PCT公布WO 00/44914；PCT公布WO 01/29058；以及PCT公布WO 01/75164。

RNA干扰(RNAi)是基于双链RNA分子，进入细胞质蛋白复合体，然后有针对性地补充细胞RNA，并特异性地降解它。RNA干扰响应以含siRNA的核酸内切酶复合体为特征，即通常所说的RNA诱导的沉默复合体(RISC)，其介导具有与siRNA双螺旋结构的反义链互补序列的单链RNA的裂解。目标的裂解可发生在与siRNA双螺旋结构(Elbashir et al.，Genes Dev.，2001，15(2)：188-200)的反义链互补的中间区域。更详细的说，较长的dsRNA通过III型核糖核酸酶(DICER，DROSHA，etc.；Bernstein et al.，Nature，2001，409(6818)：363-6；Lee et al.，Nature，2003，425(6956)：415-9)裂解为短(17-29BP)的双链RNA片段(也称为短抑制RNA，“siRNA”)。RISC蛋白复合体识别这些片段和互补的mRNA。整个过程通过目标mRNA的核酸内切酶裂解达到顶峰(McManus & Sharp，Nature RevGenet，2002，3(10)：737-47；Paddison & Hannon，Curr Opin Mol Ther.2003，5(3)：217-24).(For additional information on these terms andproposed Mechanisms，见，例如，Bernstein et al.，RNA 2001，7(11)：1509-21；Nishikura，Cell 2001，107(4)：415-8和PCT公开WO01/36646)。

几组已描述了能够在细胞内产生siRNA的DNA载体的发展。该方法通常涉及短发夹RNA的转录，其能高效地加工，以在细胞内(Paddison et al.PNAS USA 2002，99：1443-1448；Paddison et al.Genes& Dev 2002，16：948-958；Sui et al.PNAS USA 2002，8：5515-5520；和BrumMelkamp et al.Science 2002，296：550-553)形成siRNA。这些报道描述能够特异性地靶向内源性和外源性基因表达的方法。

本发明已通过说明性的方式进行了描述，要了解的是，所使用的术语是为了说明而不是限制词的性质。

显然地，本发明的许多修改和变化可能是根据上述精神。因此，应当理解为所附权利要求范围内，除了具体描述外本发明可以实施。

在整个申请中，包括美国专利的各种出版物，都是通过作者、年份和专利号而引用。这些出版物和专利申请在此以全文纳入本申请并引用的披露，是为了更充分地描述本发明所属技术领域的方法水平。

以下通过有关实例对本发明进行详细说明，但不应被解释为是对本发明的限制。

此处的任何文件引用并非为了承认此文件是有关现有技术，或本申请任何权利要求的考虑材料。关于任何文件内容或日期的任何声明是基于申请人在申请日期提供的资料，并不构成这种声明正确性的承认。

实例

如果没有进一步阐述，据认为，所属技术领域的普通技术人员可以通过前述说明，充分利用本发明。以下优选的具体实施例，因此，被解释为仅仅是说明之用，并不以任何方式限定所声明的发明。

此处并不具体说明的所属技术领域已知的标准分子生物学试验，通常基本上参见Sambrook et al.，Molecular cloning：A laboratorymanual，Cold Springs Harbor Laboratory，New-York(1989，1992)，以及如Ausubel et al.，Current Protocols in Molecular Biology，JohnWiley and Sons，Baltimore，Maryland(1988)，以及Ausubel et al.，Current Protocols in Molecular Biology，John Wiley and Sons，Baltimore，Maryland(1989)以及Perbal，A Practical Guide toMolecular Cloning，John Wiley & Sons，New York(1988)，以及Watson et al.，Recombinant DNA，Scientific American Books，NewYork and in Birren et al(eds)Genome Analysis：A LaboratoryManual Series，Vols.1-4Cold Spring Harbor Laboratory Press，NewYork(1998)以及美国专利No.4,666,828；4,683,202；4,801,531；5,192,659和5,272,057所示的方法，并在此以引用方式纳入。聚合酶链反应(PCR)依照标准PCR操作规程：A Guide To Methods AndApplications，Academic Press，San Diego，CA(1990)进行。原位PCR与流式细胞术(FACS)联合可用于检测含特异DNA和mRNA序列的细胞(Testoni et al.，Blood 1996，87：3822.)。RT-PCR的测试方法是所属技术领域公知的。

细胞培养

如Czauderna，et al.(NAR，2003.31：670-82)所述，对海拉细胞(美国菌种保藏中心)进行了培养。对人体角质化细胞在37℃含10％FCS的Dulbecco修饰Eagle培养基(DMEM)中进行培养。对小鼠标细胞系，B16V(美国菌种保藏中心)在37℃含10％FCS的Dulbecco修饰Eagle培养基(DMEM)中进行培养。培养条件在(Methods Find ExpClin Pharmacol.1997，19(4)：231-9)中有所描述。

在每一种情况下，细胞受到此处所述每孔细胞密度约50,000的实验影响，根据本发明的双链核酸是以20nM的浓度添加，即双链核酸是使用如下所述1μg/ml的专有脂质合成。

在组织化学/微观图像中，添加箭头是为了提示组织染色。

动物模型

青光眼和视网膜神经节细胞死亡的模型系统(RGC)

大鼠的ONC模型

不同动物模型是用于研究siRNA疗法对青光眼的治疗效果。在大鼠视神经损伤模型中，麻醉大鼠的眼窝视神经(ON)显露是通过眼眶路径、切断的脑膜以及通过使用钳子10秒内将筛状板压碎成2mm的横断ON的所有轴突。对治疗或预防青光眼的本发明(如siRNA)活性抑制剂进行测试，例如，在Pease et al.(J.Glaucoma，2006，15(6)：512-9所述的动物模型中(J.Glaucoma，2006，15(6)：512-9.)。患有实验性青光眼的大鼠与正常小鼠的TonoLab和TonoPen眼压计测压校准和比较)。

成年大鼠的视神经损伤(ONC)模型也是研究视网膜神经节细胞(RGC)死亡的可接受模型。RGC发病和死亡的动力学模型重现性非常好；RGC细胞凋亡在RGC后4-5天开始；在RGC后7-10天观察到大量的RGC缺失(约50-60％)；和95％的RGC缺失在RGC后3-4天按周发生。这种模型允许建立测试药物在体内的神经保护功效。

在一些非限制性实例中，对表A1-A4所示基因靶向siRNA化合物在动物模型中进行测试，其显示当局部无创伤性传输到眼睛后，这些siRNA化合物能治疗和/或预防青光眼和/或RGC死亡。

小鼠的IOP模型

眼内压(IOP)是眼内液体压力的测量。这种流体称为房水，通过专门的外流途径流通和流出。如果排水系统不能正常运行，如青光眼的普遍形式，眼内压力积聚。Dr.J.Morrison和collaborators在Casey眼科研究所(Portland，Oregon)研究的灰色挪威鼠高眼压模型用于这项研究。Morrison模型涉及到高渗生理盐水静脉注射入巩膜，导致房水外流途径的阻塞。此过程会导致眼睛压力的逐渐增加以及RGC的逐渐死亡。重要的是，这个模型中观察到的内层视网膜萎缩、视神经退化、视神经头重建与人类青光眼类似。因此，Morrison模型被认为是最好的啮齿动物青光眼临床前模型。

大鼠体内轴索切断模型

在这个模型中，RGC细胞凋亡是通过成年Sprague-Dawley大鼠(ON)的视神经切断诱导的。这个模型系统中RGC死亡的发生和动力学的重现性非常好，并考虑到建立体内无创伤性地施用siRNA化合物的神经保护功效。使用这种方法，RGC死亡随时间的变化遵循一个可预测的过程：细胞死亡从第5天开始，并继续下去到2周后，这些神经细胞超过90％的迅速丧失。

载体配方和典型的滴眼剂配方

水相滴眼剂配方可选择地包含各种通常加入的添加剂，如缓冲剂(例如，磷酸盐缓冲液、硼酸盐缓冲液、柠檬酸盐缓冲液、酒石酸盐缓冲液、醋酸盐缓冲液、氨基酸、醋酸钠、柠檬酸钠等)，等渗性(例如，糖类，如山梨醇、葡萄糖和甘露醇，多元醇，如丙三醇、浓缩丙三醇、聚乙二醇和丙二醇，盐类，如氯化钠)，抗菌剂或防腐剂(例如，苯扎氯铵、苄索氯铵、对-氧化苯甲酸酯，如甲基对-氧化苯甲酸酯或乙基对-氧化苯甲酸酯、苯甲醇、苯乙醇、山梨酸或其盐，硫柳汞、氯丁醇等)，增溶酸或稳定剂(例如，环糊精及其衍生物，水溶性聚合物，如聚乙烯吡咯烷酮)，表面活性剂，如聚山梨酯80(吐温80))，pH值调节剂(例如，盐酸、醋酸、磷酸、氢氧化钠、氢氧化钾、氢氧化铵等)，螯合剂(如，乙二胺四乙酸钠、柠檬酸钠、浓缩磷酸钠)等。

水相悬浮形式的滴眼剂配方还可能包含悬浮剂(例如，聚乙烯吡咯烷酮、单硬脂酸丙三醇酯)和分散剂(例如，表面活性剂，如，泰洛沙泊和聚山梨酯80，离子聚合物，如海藻酸钠)，除上面列出的添加剂外，从而确保滴眼剂配方是进一步均一的微粒物和令人满意的分散水性悬液。

眼软膏可包括已知的软膏基质，如纯净绵羊油、凡士林、液体石腊和聚乙烯的复合软膏基质、液状石蜡、聚乙二醇等。

典型滴眼剂制剂1：

PBS中的siRNA化合物制剂(“赤裸siRNA配方”)通常是通过在PBS中溶解干的siRNA制得。该制剂包括至少一种按组合物体积计通常存在量为约5μg/μl至约60μg/μl的siRNA化合物。

在一个非限制性实例中，siRNA化合物在PBS中的制剂制备如下：在无菌条件下，将500mg干的siRNA溶解于25ml无菌双蒸水(DDW)中，以获得20mg/ml的溶液。将该溶液储存在80℃下，待用。然后DDW中的20mg/ml原溶液在PBS中采用100μg/3μl的工作浓度，情况如下：将325μl 20mg/ml的siRNA原液(6.5mg)通过0.15M NaCl和EtOH沉淀，并在组织培养层(不育条件)条件下干燥。将6.5mg干的siRNA溶解于130μlPBS中，以形成滴眼剂制剂1。

典型滴眼剂制剂2：

在一些实施例中，在1M的三(羟甲基)甲胺(TRIS)中(pH 8.0)配制(得自，例如，Sigma(目录#T-1503))至少一种siRNA化合物。

在一个非限制性实例中，将121.1g TRIS基质(Sigma#T1503)溶解于700ml ddH2O中。通过添加浓HCl.达到所需的pH 8。添加DDW以得到最终的1L溶液。在无菌条件下，将42.426mg siRNA化合物粉末溶解于2.1ml无菌双蒸水中，以获得一20mg/ml(1.5mM)的原液。将该原液储存在80℃下，待用。在无菌条件下，将相应量的siRNA原液冻干，并悬浮于相应量的1M TRIS  (pH 8)中。

典型滴眼剂制剂3：

所用的增粘剂浓度通常在约0.05至约5.0％(w/v)之间，较理想地，在约0.1至约3.0％(w/v)之间。一种优选的眼科组合物包括约0.01至约0.075％(w/v)的有效成分；约0.15至约2.5％((w/v)的硬脂酸聚烃氧(40)酯；约0.1至约3.0％(w/v)的选自25羟丙甲纤维素或羟乙纤维素的纤维素增稠剂；以及约0.0001％至约0.01％(w/v)的选自丁羟甲苯或硫代硫酸钠的抗氧化剂。

表面活性剂的组合，如含siRNA的硬脂酸聚烃氧(40)酯或十六烷基聚氧乙烯醚或辛基苯基聚氧乙烯醚制成的滴眼剂制剂，对眼睛的刺激低，并在眼睛中提供更好的分布，具有更高的稳定性。抗氧化剂和纤维素增稠剂的加入进一步提高了活性治疗剂(即siRNA)在眼睛中的分布和稳定性。

也可以增加其它赋形剂，例如，等渗剂、缓冲剂、防腐剂和/或pH值控制剂。存在有适量的无菌纯净水，以获得所需的滴眼剂制剂。

眼科组合物的pH值在本领域公知的范围内，通常用作眼科制剂，但在5至8范围内是理想的。该制剂进一步包括至少一种按组合物体积计通常存在量为约6.6μg/μl至约50μg/μl的siRNA化合物。

典型滴眼剂制剂4：

在药物到晶状体的局部传输中，药物在眼睛表面的保留被认为是重要的。不希望被理论束缚，增加眼睛表面的保留导致通过角膜进入房水以及随后的晶状体增加眼部的药物吸收。

在一些实施例中，优选为局部悬浮。局部悬浮的非限制性实例包括：(1)羟丙甲纤维素(HPMC，0.5％w/v)，(2)黄原胶(0.5％w/v)，(3)结冷胶(0.5％w/v)，(4)卡波姆(0.25％w/v)和(5)卡波姆(0.25％w/v)-羟丙甲纤维素(HPMC)(0.25％w/v)。使用粘度计进行粘度测量。

该制剂进一步包括至少一种按组合物体积计通常存在量为约5μg/μl至约60μg/μl的siRNA化合物。

典型滴眼剂制剂5：

在眼科组合物中，可任选地使用螯合剂，以提高防腐效果。合适的螯合剂是本领域公知的，而且，虽然不是旨在限制，如乙二胺四乙酸二钠、乙二胺四乙酸二钠钙、乙二胺四乙酸钠、乙二胺四乙酸三钠和乙二胺四乙酸二钾的乙二胺四乙酸盐(EDTA)是有用的螯合剂实例。据了解，EDTA指的是一种具有四个羧酸官能团的物质，而这些羧酸官能团可能是质子化或去质子化的(即以盐的形式)，这取决于它所处组合物的pH值。

缓冲剂通常用来调整pH值至所需的眼用范围。一般来说，大约5-8的pH值是所需的，然而，这可能需要加以调整，如因考虑到治疗活性剂或其他赋形剂的稳定性或溶解度。

另一种常用于眼科组合物的赋形剂是一种增粘剂或增稠剂。增稠剂可用于各种原因，从改善简便给药的制剂类型到改善与眼睛的接触，以提高生物利用度。增粘剂包括含亲水基，如单糖、多糖、环氧乙烷基、羟基、羧酸或其他带电官能团的聚合物。虽然不是旨在限制一些实例，有用的增粘剂是羧甲基纤维素钠、羟丙基甲基纤维素、聚维酮、聚乙烯醇、聚乙二醇。

该制剂进一步包括至少一种按组合物体积计通常存在量为约5μg/μl至约60μg/μl的siRNA化合物。

典型滴眼剂制剂6(“制剂A”)：

制剂“A”：配制2份溶液，A和B.

溶液A的配制：4％的甲基纤维素水溶液，将0.4g甲基纤维素25(ScienceLab.com，Cat#SLM2050)溶解于最终体积为10ml无热源注射用水(WFI)的50mL无菌管(Norbook，Cat#7082-51)中。将无菌搅拌器放入，并关闭帽。置于沸水浴中并搅拌至少5分钟，直到形成一乳白色甲基纤维素溶液。

溶液B的配制：2％丙三醇；0.02％(v/v)EDTA溶液。添加333.3uL的60％丙三醇溶液(Sigma，Cat#G6279)及2μl的0.5M EDTA，pH＝8(Sigma，Cat#E9884)(最终-100uM)到9.665ml WFI(Norbook，Cat#7082-51)中最终体积-10mL。

在溶液B中配制siRNA 2倍(关于工作浓度)溶液。注意：如果储备siRNA体积相当高，溶液B的最终体积最好保持在低于10mL，以允许在siRNA溶液中调节体积。

工作siRNA溶液的配制：

将溶液A在手中冷却至40-50℃(还是液体)，并与溶液B中等体积的siRNA 2倍溶液混合至所需体积。

最终siRNA制剂包含WFI中的2％甲基纤维素、1％丙三醇和0.01％(v/v)(50uM)EDTA。最终pH值应为～7.4和渗透摩尔浓度-类似于人类的泪膜。siRNA在最终制剂中的浓度为33.3mg/ml。

必须每周重新配制一次，分成为小份以备日常使用。将小份保存于4℃下。使用前，药剂在室温下预热20-30分钟。

甲基纤维素的最终浓度为约0.1％至约3％w/v，约0.1％至约2％w/v，约0.1％至约1.5％w/v甲基纤维素，优选为约2％w/v。丙三醇的最终浓度为约0.1％到约5％v/v，，约0.5％至约2％，优选为约1％v/v。EDTA的最终浓度为约0.001％至约0.05％，约0.005％至约0.01％，优选为约0.01％w/v。

典型滴眼剂制剂7：

在一些实施例中，siRNA是在市售的润滑滴眼剂中配制。市售润滑滴眼剂的非限制性实例是得自Alcon Inc的

这种市售润滑滴眼剂的制剂通常包括聚乙二醇和/或丙二醇，抗菌剂和/或抗病毒剂，如硼酸，胶凝剂，如羟丙基瓜尔胶、氯化钾和/或氯化钠和/或氯化镁和/或氯化钙和/或氯化锌，防腐剂，如

和纯净水。在无菌条件下，将300mg siRNA粉末溶解于15ml无菌双蒸水中，以得到一清澈的20mg/ml溶液。将该溶液储存于-80℃下，待用。然后在制剂中将200mg/ml双蒸水原溶液稀释为100μg/3μl工作浓度，具体如下：

为得到最终配制量为1.7mg的siRNA：将85μl的20mg/ml siRNA原液通过0.155M NaCl和EtOH而沉淀，并在组织培养层(无菌条件下)干燥。

为得到33.3mg/ml的siRNA溶液，将1.7mg干的siRNA溶解于51μL

中。

siRNA化合物诱导目标基因的抑制(KD)

实施例1：siRNA化合物的体外试验

大约1.5-2x10⁵个测试细胞(siRNA目标基因和NRK52(正常大鼠肾脏肾小管上皮细胞)细胞和/或siRNA目标大鼠/小鼠基因的NMuMG细胞(小鼠乳腺上皮细胞系)的HeLa细胞和/或293T细胞)在6孔板(70-80％融合)中分别接种于每孔。

约24小时后，在最终浓度为5nM或20nM时使用Lipofectamine^TM 2000试剂(Invitrogen)将siRNA化合物转染细胞。这些细胞分别置于37℃的CO₂培养箱中培养72小时。

至于转磷酸酶和张力蛋白同源(PTEN)-Cy3标记siRNA化合物的阳性对照也被用到。对含有交替修饰和未修饰核苷酸(在正义和反义链的糖残基的位点2′是修饰的，其中位点2’的基团是甲氧基)的各种化学修饰的钝端siRNA化合物进行了测试，其中反义链5’和3’末端的核糖核苷酸在其糖残基是修饰的，正义链5’和3’末端的核糖核苷酸在其糖残基是未修饰的。另一个siRNA化合物包括含有甲氧基基团和通过3’末端的2’5’桥连接的具有3个核糖核苷酸的正义链的交替模型的含反义链钝端结构；包括含有3个通过3’末端的2’5’桥连接的核糖核苷酸的反义链和正义链的另一个siRNA化合物被用到。一些测试化合物包括含有甲氧基基团和3’末端或3’倒数第二位置的一个或两个L-核苷酸的正义链的交替模型的含反义链钝端结构。

绿色荧光蛋白的siRNA化合物被用作siRNA活性的阴性对照。在转染72h后，收获细胞，从细胞中提取RNA。通过荧光显微镜检测转染效率。使用特定的优选siRNA结构对基因表达的抑制比例进行了测定，并在表达内源性基因的细胞内进行了定量PCR分析。

一般情况下，被选出进行体外检测的具有特定序列的siRNA对人类和第二个物种，如非人类的灵长类动物，老鼠或兔子的基因是特定的，类似的结果，使用含有这些RNA序列和此处所述修饰的siRNAs得到类似的结果。

通过相似的步骤对与细胞凋亡和神经保护作用相关的siRNA定位基因进行了测试，并被发现能够主动诱导其相应目标基因的抑制。

将无创伤性施用的备用siRNA通过滴眼剂传输到体内的目标视网膜组织

实施例2：通过荧光显微术和共焦显微术监测鼠科动物眼部组织中(PBS中配制的siRNA)Cy3标记的siRNA的分布

目前研究显示，体内的siRNA通过局部眼路径传输到泪腺和眼部结构。

缩写词：E.D.＝滴眼剂；ISH＝原位杂交

这项研究的目的是对DDIT4-Cy3标记siRNA(siRNA化合物靶向RTP801基因)通过无创伤性局部眼路径传输到泪腺进行测试。已经评价了siRNA传输到泪腺、眼前房、视网膜和视神经的局部眼路径。

材料和方法

表C1：动物

种/株：	小鼠/ICR，雄性
		年龄：	6-10周
体重范围：	27-32g
		组大小：	2
动物总数：	26

在PBS中将DDIT4-Cy3siRNA(小鼠RTP801的siRNA)配制为20m-/ml原液，并在-80oC下保存，待用。

实验步骤

该研究包括如下文表C2所述的6个实验组：使用单siRNADDIT4-Cy3对小鼠进行处理如下：

组V(A和B)：剂量方案：50μg/小鼠/3μl/眼睛，给药途径：右眼，滴眼剂(E.D.)；

组Am-V-A、Am3-VIII、Am3-IX：剂量方案：50μg/小鼠/3μl/眼睛，给药途径：两只眼睛，滴眼剂(E.D.)；

组VI-A：剂量方案：20μg/小鼠/3μl/眼睛，给药途径：右眼，滴眼剂(E.D.)；

组VII、Am-VII：未处理对照。

表C2研究设计

在无菌条件下，配制siRNA的剂量。在给药前，将小份siRNA在室温下解冻至少30分钟。总量的每小份(每只小鼠)包括了计算量的另外20％。将指定的siRNA剂量以每眼量3μl(实验组V-VI)传输。

麻醉：使用如下的氯胺酮/甲苯噻嗪组合对小鼠进行麻醉：0.85ml氯胺酮+0.15ml甲苯噻嗪+0.9ml生理盐水，0.1ml混合溶液20g体重(BW)。

滴眼剂(E.D.)传输：使用钝吸管端将一3μL样品量缓缓滴入经处理的眼睛(角膜表面)中；将动物安置于温暖的环境中，以防止麻醉引起的低体温，并在恢复意识后返回笼子。

预定的安乐死：治疗后，根据研究设计对各组小鼠施行安乐死(表C2，时间点终止)。

通过心脏穿刺采血完成终止步骤；将收集的血清/血浆储存(-20℃)，以作进一步的siRNA血液检测分析。

组织收集：包括所有动物离体的视神经、泪腺(左和右)的左眼和右眼、各组动物(V-A到VII、Am3-VIII、Am3-IX)离体的脑组织(大脑的前部和中部，正面导向部分)在最佳切削温度(OCT)嵌入化合物，用低温恒温器分段成8μm切片并置于显微镜载玻片(Superfrost/Plus^TM)上。将切片在95％乙醇中固定7分钟，然后用DAPI(1μg/ml)染色，在纯乙醇中培养1分钟，在二甲苯培养5分钟，风干，并安装。

组织评价：利用光学显微镜和数码图像对siRNA的传输进行评价。只有当组织学(微观)检测显示在特定细胞或结构内，如腺泡单独或与泪腺的导管细胞结合结构内有清晰的荧光信号时，组织片段才被认为是阳性的(即成功的Cy3标记DDIT4siRNA细胞内纳入)。背景DAPI染色有助于组织结构鉴定：对于眼前房结构，如角膜、角、睫状体或眼后房，如视网膜(视网膜色素上皮细胞(RPE)、视网膜神经节细胞(RGC))。如果组织学检测将显示：一组中的所有动物实验表明在被研究的细胞类型/组织中出现相同的荧光信号，传输被认为是阳性的。(即时间点或给药路径)。

结果与讨论

在光学显微镜(明视野，BF)和荧光共聚焦显微镜下，对所有的冰冻切片进行了分析。荧光信号在以下组织中是可视化的：

视网膜E.D.传输(视网膜色素上皮细胞，视网膜神经节细胞)1A-1B：Cy3标记的siRNA DDIT4纳入小鼠视网膜的典型图像。

图1A：在E.D.给药后1小时的视网膜的荧光显微镜图像(上图，放大X40)。右箭头标识Cy3染色视网膜神经节细胞(RGC)，左箭头标识Cy3染色视网膜色素上皮细胞(RPE)。视网膜神经节细胞层的共聚焦显微镜图像(下图，放大X60)。9个下位图显示了Cy3标记组织(左)，明视野(BF，中心)和两个的合并(M，右)。箭头指向标记的RGC。

图1B：在E.D.给药后4小时的视网膜的共聚焦显微镜图像，给药(上X40，下X60)。RGC的Cy3染色是显著的。

siRNA到泪腺的滴眼剂传输(腺泡细胞，导管细胞)图2A-2D：代表的Cy3标记的siRNA DDIT4纳入小鼠泪腺导管及腺泡细胞的典型图像。

图2A：在E.D.给药后1小时的视网膜的荧光显微镜图像(M＝合并的DAPI-Cy3染色)。中心箭头指向腺泡细胞，右箭头指向导管上皮细胞，灰色的左箭头指向泪管(放大X60)

图2B：在E.D.给药后1小时的泪腺的共聚焦显微镜图像(上X40，下X60)。合并后图像M的箭头指向泪管。

图2C：在E.D.给药后1小时的泪腺的共聚焦显微镜图像(X40)。箭头指向腺泡细胞。

图2D：在E.D.给药后4小时的泪腺的共聚焦显微镜图像(X60)。

图3A-3C显示通过滴眼剂给药1到4小时后大鼠脉络膜的Cy3-siRNA的累积随时间的变化过程。脉络膜、外核层、RPE和感光细胞外段层显示Cy3染色。

图4显示在滴眼剂给药后1小时的Cy3-siRNA传输到小梁网末端睫状体。

使用小鼠Cy3标记的siRNA对不同的化学修饰siRNA(构造动机)进行了测试。对上面显示的所有测试结构观察得到类似的组织分布：在两条链上含有交替的天然核糖核苷酸和2′O-Me糖基修饰核糖核苷酸的结构B，在反义链和通过正义链3’末端的2’5’核酸间连键连接的3个核糖核苷酸上含有交替的天然核糖核苷酸和2′O-Me糖基修饰核糖核苷酸的结构I，以及含有通过每个反义和正义链3’末端的2’5’核酸间连键连接的3个核糖核苷酸的结构。

实施例3：大鼠体内配制siRNA的眼局部传输路径的测试(PBS 或2％甲基纤维素中配制的siRNA(“制剂A“))

在目前的研究中，PBS或制剂A中配制的DDIT4-Cy3siRNA的眼部传输，通过对大鼠施用滴眼剂进行了研究。

表C3：研究设计

实验设计：

1)第I、第II、第III、第IV、第V组：剂量方案：制剂A中配制的siRNA；100μg/大鼠/3μl/眼，给药路径：双侧滴眼剂(E.D.)；

2)第Ia、第IIa、第IIIa，、第IVa、第Va组：剂量方案：PBS中配制的siRNA；100μg/大鼠/3μl/眼，给药路径：双侧滴眼剂(E.D.)；

3)第VI组：剂量方案：经制剂A(无siRNA)中载体处理的对照组；100μg/大鼠/3μl/眼，给药路径：双侧滴眼剂(E.D.)；

4)第VII组：完整对照

在无菌条件下，配制siRNA的剂量。在给药前，将小份siRNA在室温下解冻至少30分钟。总量的每小份(每只小鼠)包括了计算量的另外20％。将指定的siRNA剂量以每眼量3μl传输。

麻醉：使用Equithesine(4ml/kg)对组I-VII的大鼠进行麻醉

终止步骤：在研究结束时，通过Equithesine(4ml/kg)将动物深度麻醉。此后，根据蠕动泵标准方案对大鼠皮质内灌注新鲜的10％中性缓冲用福尔马林。

组织收集：摘除包括所有动物视神经的左眼和右眼，在室温下穿孔后固定在缓慢转动的10％中性缓冲福尔马林中另外1小时，通过蔗糖梯度逐步冷沉淀保护于4℃下过夜，冷沉淀保护最佳的切削温度(OCT)化合物后于4℃下过夜旋转，将OCT化合物嵌入，并用低温恒温器分段成12μm切片置于显微镜载玻片(Superfrost/Plus)上。将切片用DAPI(1μg/ml)进行反染色，并安装。

利用光学显微镜和数码图像对siRNA的传输进行评价。如果组织学检测将显示：一实验组中的所有动物实验表明在特定的组织/细胞类型中出现相同的荧光信号，组织片段被认为是阳性的(即，眼前房、视网膜和视神经中成功的Cy3 DDIT4_1 siRNA转移被认为是阳性的)。

结果：在光学显微镜(明视野，BF)和共聚焦荧光显微镜下对所有的冰冻切片进行分析。视网膜色素上皮细胞和视网膜神经节细胞中的荧光信号是可视化的。值得注意的是，给药3小时后，PBS中配制的化合物在眼组织中达到最大分布，且在6h时间点清理所述组织。然而，在给药后24小时，制剂A中配制的化合物在眼组织中达到最大分布。

实施例4：食蟹猴的siRNA(在PBS中配制)眼分布

表C4：实验设计

ED＝滴眼剂，局部地

这项研究的目的在于分析向Cynomolgus Macaca fascicularis猴眼睛表面眼单一局部给药后，PBS中配制的siRNA的组织分布。将所有组织以一式三份～1～2g样品或作为整体进行适当地捕捉冷冻。

RNA纯化

将冷冻样品在液氮中粉碎成细粉。将少量粉状组织用于RNA提取。剩余组织储存在80℃下，待用。使用MicroPoly(A)Purist mRNA纯化试剂盒(#1919)从每个样品中提取多聚腺苷酸RNA，并根据poly(A)RNA从组织或细胞分离的制造商说明书进行处理。RNA的最终产量和光谱特征总结于下表C5中。

表C5：猴子的多聚腺苷酸RNA

组织	260/280	260/230	浓度μg/μl	产量μg
					淋巴结	1.58	0.92	0.104	1.55
脾脏	1.74	1.27	0.175	2.62

将得自脾的1μg和得自淋巴结的0.7μg多聚腺苷酸RNA制剂用于采用随机引物合成的cDNA。从两次cDNA制备中成功地扩增出Casp2基因。

结果总结于下表C6中。

表C6：结果

治疗	分析的组织	终止时间	Av	SD	组大小
						ED(REDD14)	神经视网膜	1h	0.2	[+/-0]	1(2只眼)
ED(REDD14)	神经视网膜	5h	0.05	[+/-0.03]	1(2只眼)
						ED(REDD14)	视网膜色素上皮	1h	0.62	[+/-0.05]	1(2只眼)
ED(REDD14)	视网膜色素上皮	5h	0.1	[+/-0.07]	1(2只眼)
						ED(REDD14)	视神经	1h	8.9	[+/-2.6]	1(2只眼)
ED(REDD14)：	视神经	5h	3	[+/-1.9]	1(2只眼)

结论：向Cynomolgus Macaca fascicularis猴眼睛表面眼单一局部给药后，PBS中配制的siRNA到达神经视网膜，并可以由S&L定量PCR法测定。

实施例5：siRNA(TRIS中配制)传输到小鼠目标视网膜组织

不同荧光标记的siRNA分子的局部传输的测试。

1小时给药后，(TRIS)(1M，pH 8)中配制的20ug不同荧光标记的siRNA局部传输到小鼠。

测试的siRNA：

Cy3-QM5；Cy3-DDIT4；Cy3.5-DDIT4；DDIT4_1 Dy-649/C6；FITC-CNL_1；3′Cy3-CNL_1；Cy3-Casp2_4 L-DNA；Cy3-AS-Casp2_4；TGASEII-FAM；HNOEL-FAM.(QM5是p53靶向大鼠/小鼠siRNA；CNL是对照无规则的siRNA)

典型的化学修饰Casp2 siRNA化合物，分别如下：

1.正义：GCCAGAAUGUGGAACUC2pC2pU，17和18是2′-5′-桥接反义：mAGmGAmGUmUCmCAmCAmUUmCUmGGmC-cy3

2.正义：GCCAGAAUGUGGAACUC；LdC；LdT 18和19是L-DNA

反义：mAGmGAmGUmUCmCAmCAmUUmCUmGGmC-cy3

3.正义：GCCAGAAUGUGGAACUC；LdC；U 18是L-DNA基

反义：mAGmGAmGUmUCmCAmCAmUUmCUmGGmC-cy3

LdC，LdT指的是L-DNA核苷酸，mA，mC，Mg，Mu的是2’O-甲氧基核糖核苷酸。

配制的(配制的化合物)：以下siRNA是1M Tris pH 8.0中的siRNA：QM5-Cy3#1，QM5-Cy3#10，DDIT4_1-Cy3，DDIT4_1Cy3.5，Redd14(DDIT4_1)Dy-649/C6，FITC-CNL_1RD/CNL_1FD，不规则的3′Cy3CNL 1，Cy3-AS-CASP2_4-Struc-L-DNA-s(正义链3′末端的2残基)-plus-alt AS，Cy3AS-CASP2_4-Struc2-5-s(正义链3′末端的2残基)-plus-alt AS，TGASEII-FAM，HNOEL-FAM。

配制(配制的化合物)：以下siRNA是1M Tris pH 8.0中的siRNA：QM5-Cy3#1，QM5-Cy3#10，DDIT4_1-Cy3，DDIT4_1Cy3.5，Redd14(DDIT4_1)Dy-649/C6，FITC-CNL_1RD/CNL_1FD，不规则的3′Cy3CNL 1，Cy3-AS-CASP2_4-Struc-L-DNA-s(正义链3′末端的2残基)-加-alt AS，Cy3AS-CASP2_4-Struc2-5-s(正义链3′末端的2残基)-plus-alt AS，TGASEII-FAM，HNOEL-FAM。

表C7：制剂

测试材料的描述：在无菌条件下，将相应量的siRNA原料冻干，并在相应量的1M Tris pH8(见表C7)中再悬浮。

供给量：每个测试siRNA的一个基质(由Biospring，AG合成)

储存条件：冷冻，待用。使用前，将样品解冻，并在室温保持30分钟。

对照物(S)

阳性对照-PBS中的DDIT4_1-Cy3，批次#：117821

测试材料的描述：在无菌条件下，将42.426mg DDIT4_1-Cy3粉末(BioSpring)溶解于2.1ml无菌双蒸水，以得到一清晰的20mg/ml(1.5mM)溶液。将该溶液储存在-80℃下，待用。

载体-1M Tris pH 8.0-外购自Sigma(目录#T-1503)。降121.1gTris碱(Sigma公司#T1503)溶解于700ml双蒸水中。使用浓盐酸得到所需的pH值8。添加DDW，以达到最终1L溶液。

载体-PBSX10-外购自Biological Industries(目录#02-023-5A；(10x PBS)批次#：619113)

测试系统

动物：

物种：小鼠；株：RTP-801WT；CMF-608WT

来源：Harlan Laboratories，Jerusalem，Israel.

年龄：8-12周；体重范围：17-28g

性别：雄性；组大小：1；动物总数：14

畜牧业：饮食：向动物提供任意的市售啮齿动物食物，并能自由获得饮用水。环境：(i)至少5天的驯化。(ii)在整个研究期间，将所有动物关在一个控制居住条件的专用设施中，并根据规定的操作规程(SOP)维持不变。

实验设计

综述：该研究包括表C8所述的14个实验组：

实验组1-12，通过滴眼剂传输siRNA，组13，通过滴眼剂传输载体[经TRIS 1M pH8处理的对照组]以及组14(未处理的对照组)。使用单siRNA处理小鼠如下：

-组1-9和12：剂量方案：20μg/眼/3μl/SiRNA，组10：剂量方案：5.81g/eye/3μl/siRNA，组11：剂量方案：2.24μg/眼/3μl/siRNA给药路径：滴眼剂(E.D.)；

-组13：载体(TRIS 1M pH8)3μl/眼对照

-组14：未处理对照

表C8.研究设计

在无菌条件下，配制siRNA的剂量，并储存在-20℃下。在给药前，将小份siRNA在室温下解冻至少30分钟。总量的每小份(每只眼睛)包括了计算量的另外20％。将指定的siRNA剂量以每眼量3.5.μl(实验组1至9和12)传输。将指定的siRNA剂量以每眼量3.2.μl(实验组10和11)传输。

麻醉：使用如下的氯胺酮/甲苯噻嗪组合对小鼠进行麻醉：0.85ml氯胺酮+0.15ml甲苯噻嗪+0.9ml生理盐水，0.1ml混合溶液20g体重(BW)。

滴眼剂传输：使用钝吸管端将一3μL样品量缓缓滴入经处理的眼睛(角膜表面)中；将动物安置于温暖的环境中，以防止麻醉引起的低体温，并在恢复意识后返回笼子。

预定的安乐死：治疗后，根据研究设计对各组小鼠施行安乐死(表C8，时间点终止)。

通过颈椎脱臼法完成终止步骤。

组织收集：摘除包括所有动物视神经的左眼和右眼，用刀片将视网膜横向切开，将晶状体/玻璃体轻轻取出。用4％PFA(在PBS中pH 7.4)固定剩下的眼罩30分钟，然后用30％的蔗糖在4℃下浸润3小时。用冰冷的PBS清洗3X5分钟。预冷0.01M pH7.4。然后将其嵌入最佳切削温度(OCT)化合物中，并用低温恒温器纵向分段成4μm切片置于显微镜载玻片(Superfrost/Plus)上。将该切片用DAPI(1μg/ml)进行反染色，并安装。

将所有的动物全滴血用盖玻片涂抹在滑板上，并覆盖。然后用指甲油胶合。

评价

组织评价：利用光学显微镜和数码图像对siRNA的传输进行评价。只有当组织学(微观)检测显示在特定细胞或者眼前房或眼后房结构和视网膜内有清晰的荧光信号时，组织片段才被认为是阳性的(即成功的siRNA转移\细胞内纳入)。背景DAPI染色有助于组织结构鉴定。如果组织学测试在组(双边相同的细胞类型或结构染色)内是一致的，传输被认为是阳性的。同样的实验组中的所有细胞类型/组织(眼前房、视网膜和视神经)出现相同的荧光信号，传输被认为是阳性的。

结果

图5A-5B：p53基因靶向QM5-siRNA的滴眼剂给药后1小时视网膜的共聚焦显微镜(放大X60)图像。Cy3标记荧光显示了视网膜(视网膜色素上皮细胞，视网膜神经节细胞)的siRNA。

图6A-6B是Cy3标记的DDIT4 siRNA纳入小鼠视网膜的典型图像。

图6b显示滴眼剂给药后1小时DDIT4_1 Cy3-siRNA的累积。脉络膜、外核层、RPE和感光细胞外段层显示Cy3标记染色。

图7显示滴眼剂在RGC细胞内给药1小时后使用Dy-649/C6染色的累积。

图8A-8C表示对照siRNA FITC-CNL_1RD/CNL_1FD和不规则的3′cy3-CNL_1通过不同染色方法传输到视网膜组织。

图9A和9B显示的是Casp2的不同结构传输到小鼠视网膜组织。

图10A和10B显示的是TGASEII-FAM和HNOEL-FAM的传输。

图11显示了作为阳性对照组的PBS中p53基因靶向siRNA的视网膜传输，和

图12A和12B显示在完整的动物中，或当不含siRNA的滴眼剂给药时，视网膜上没有得到任何荧光信号。

结论：没有序列依赖性的差异，在传输到视网膜时也未发现荧光团或基因依赖性的差异也没有发现相关的差异。该研究结果显示CASP2、RTP801、TIGASEII和p53目标基因靶向Cy3共轭siRNA化合物能有效传输到眼结构：RGC、RPE、光感受细胞、脉络膜。

实施例6：Casp2siRNA(在PBS或MC 2％(制剂“A”)中配制)传输到大鼠体内目标视网膜组织的量化

siRNA传输到视网膜的不同滴眼剂制剂。这项研究的目的是在单一局部施用滴眼剂制剂后，测定大鼠视网膜在时间点1、3、6及24h时的CASP2_4_S510siRNA量。

测试物

物质(未配制的化合物)：CASP2_4_S510(CASP2靶向siRNA)

Agilent提供(制造商产品目录#QPI-1007，批次#：Q02F08002N)

测试材料的说明：CASP2_4_S510：S-反向-脱碱基5’-帽端，L-DNA 18/AS-AL。一个19个碱基长度的化学修饰钝端双螺旋结构含具有两个独立链，其中，包括未修饰核糖核苷酸(大写字母)、位点18的L-脱氧核糖核苷酸(粗体，下划线)和SEN链5′末端的反向脱氧脱碱基(IB)的正义链(SEN)，以及包括未修饰核糖核苷酸(大写字母)和式I所示位点2、4、6、8、11、13、15、17和19的2’OMe糖基修饰核糖核苷酸(小写字母)的反义链(AS)：

式I

SEN 5’iB-GCCAGAAUGUGGAACUCCU 3′

AS  3′cGgUcUuAcACcUuGaGgA 5′

储存条件：-80℃

PBS中配制的siRNA：PBS中的33.3mg/ml CASP2_4_S510(滴眼剂溶液)

测试材料的说明：在无菌条件下，将300mg干的CASP2_4_S510siRNA溶解于15ml无菌双蒸水中，以得到一清晰的20mg/ml的溶液。将该溶液储存在-80℃下，待用。然后DDW中的20mg/ml原溶液在PBS中采用100μg/3μl的工作浓度，情况如下：

6.5mg CASP2_4_S510 siRNA：325μl 20mg/ml的CASP2_4(6.5mg)原料，通过0.15M NaCl和乙醇而沉淀并在组织培养层(无菌条件下)干燥。siRNA溶液33.3mg/ml：将6.5mg干的siRNA溶解于195μl PBSx1中配制的量：6.5mg/195μl分装成4管。储存条件：重新配制。

制剂A中配制的siRNA：在2％(w/v)甲基纤维素及1％(v/v)无菌丙三醇及无热原水(滴眼剂溶液)中0.01％(w/v)EDTA溶液中的33.3mg/ml CASP2_4_S510siRNA溶液。

测试材料的说明：在无菌条件下，将300mg干的CASP2_4_S510siRNA溶解于15ml无菌双蒸水中，以得到一清晰的20mg/ml的溶液。将该溶液储存在-80℃下，待用。然后DDW中的20mg/ml原溶液在PBS中采用100μg/3μl的工作浓度，情况如下：

6.5mg CASP2_4_S510 siRNA：325μl 20mg/ml的CASP2_4(6.5mg)原液，通过0.15M NaCl和乙醇而沉淀并在组织培养层(无菌条件下)干燥。

siRNA溶液33.3mg/ml：将6.5mg干的siRNA溶解于195μl的制剂A溶液中

配制的量：6.5mg/195μl分装成4管

储存条件：重新配制

对照物

甲基纤维素制剂(无siRNA)-无热原水中的2％甲基纤维素及1％v/V无菌丙三醇及0.01％w/v EDT A溶液，配制如下：

溶液A：将0.4g甲基纤维素25(ScienceLab.com，Cat#SLM2050)溶解于终体积为10ml的热开水(80-90℃)中，(Norbrook)，冷却至室温，并以1∶1(终浓度2％)的比例添加到溶液B中。

溶液B：9.66ml注射用水(Norbrook)中332μl的60％丙三醇(Sigma，Cat#G6279)和2μl的EDTA溶液。

500μL的溶液A和500μL的溶液B混合，以得到：2％的甲基纤维素及1％v/V的无菌丙三醇及无热原水中的0.01％w/v EDTA溶液(最终pH值为约7.4，渗透压类似于人类泪膜)。

PBS由Biological industries提供(制造商目录#02-023-5A(为10xPBS)；批次#619113)。

测试系统

所用的动物：物种：大鼠；属：成年，Sprague-Dawley(SD)

来源：Harlan，Jerusalem Israel

年龄：8-10周；体重范围：180-250g

性别：雄性；组大小：n＝6/3；动物总数：54

畜牧业：饮食：向动物提供任意的市售啮齿动物食物，并能自由获得饮用水。

环境

(i)至少5天的驯化。

(ii)在整个研究期间，将所有动物关在一个控制居住条件的专用设施中，并根据规定的操作规程(SOP)维持不变。向动物提供任意的市售啮齿动物食物(rlan Teklad 2018S总量含18％蛋白质的啮齿动物食物)和过滤、加氯消过毒的酸化水。

在整个研究期间，将大鼠关在含有过滤器顶部的微型隔离器笼子中，1-6大鼠/笼。将笼子维持在受控制的环境下，温度条件(20-24℃)，相对湿度(30-70％)，12-小时光照/12小时黑暗的周期，由控制计算机监控。

实验设计

研究设计：siRNA给药后，在不同时间点终止的研究小组中通过定量PCR测定眼部制剂的滴眼剂施用后CASP2_4siRNA的视网膜浓度。每个实验siRNA治疗组包括6只大鼠。在研究设计表C9将滴眼剂详细地双侧给药。

siRNA给药后的终止时间点：根据研究设计表C9施行终止设置。剂量和实验组的终止在不同天进行。

表C9：研究设计

麻醉：在实验过程中，在滴眼剂给药时和/或终止之前使用Equithesine(I.P.4ml/kg)对动物与进行麻醉。

滴眼剂传输：使用钝吸管端(10μl无菌过滤嘴(短))将一3μL样品量施用到麻醉动物的双侧角膜表面。将动物安置于温暖的环境中，以防止麻醉引起的低体温，并在恢复意识后(实验组7和8)返回笼子。根据研究设计终止所有研究小组的动物。根据研究设计收集组织。

预定的安乐死：将所有动物深度麻醉，并根据研究设计对各组小鼠施行安乐死(表C9，终止)。

灌注计划：用PBS对大鼠经心脏进行灌胃(在2-3分钟后20-50ml/min)。

组织收集：灌注后，摘除双眼(左，右)的细胞核，储存于冰中。用显微镜解剖眼睛，并根据样品分级标准选择总病理学分级。沿角膜缘切开角膜，轻轻取出晶状体，小心翼翼地将玻璃体及视网膜与巩膜分离。收集全视网膜及玻璃体(humor)(视网膜包括：“神经视网膜”+视网膜色素上皮细胞+脉络膜)，独立适当地分成两份，适当地标记试管。用大量的PBS清洗解剖的视网膜(新配制PBS单独管中的每一个视网膜)，用

除去多余的液体，在液氮下捕捉冷冻视网膜。对视网膜和玻璃体样品进行了RNA提取。

评价

RNA提取：

视网膜：通过双提取分别从每个视网膜样品(左和右)中提取RNA。对RNA进行cDNA制备和定量PCR分析。

玻璃体：使用以下操作规程获得从玻璃体检测的Casp2_4 siRNA材料：

各组大鼠玻璃体约为10μl。将500μl试剂A EZ-RNA(BiologicalIndustries Cat no.20-410-100)添加到每个玻璃体中。样品经均质化后，添加10μgtRNA(10mg/m原液的1μl)。将该样品储存在室温下5分钟。随后：分别加入Z-RNA II B：400μl和EZ-RNA II C：90μ，并混匀。将该样品储存在室温下10分钟，然后在4℃、12000g下离心15分钟。

将上相转移到一个异丙醇的500μl新管中，添加线性丙烯酰胺5μl。将该样品储存在-20℃下过夜，在4℃、12000g下离心20分钟，用75％乙醇洗涤两次。将颗粒溶解于15μl水中。

siRNA的量化：视网膜和玻璃体中siRNA的量(siRNA的量化通过每玻璃体施行)通过定量PCR siRNA测定。根据Quark标准操作规程进行定量PCR。对CASP2_4 siRNA和参照基因表达进行了测试。结果总结在表C10中。

表C10：结果

结论：研究表明在给药1和3小时后，siRNA有效传输到视网膜。定量PCR分析表明，施用100μg siRNA后，在制剂A中，按总RNA计，在1小时后视网膜得到平均11fmol/μg siRNA，在3小时后视网膜得到平均2fmol/μg siRNA。当在PBS中施用相同浓度时，按总RNA计，在1小时后视网膜得到6fmol/μg siRNA的量，在3小时后视网膜得到8fmol/μg siRNA的量。

实施例7：大鼠目标视网膜组织中无创伤性给药的siRNA化合物(在各种制剂中配制)的量化。

siRNA的不同滴眼剂制剂在体内无创伤性地传输到视网膜的检测。

这项研究的目的是作为滴眼剂(ED)给药的不同siRNA制剂单一局部施用后3小时对正常大鼠视网膜中CASP2_4_S510 siRNA的量进行评价。

测试物

物质(未配制的化合物)CASP2_4_S510(CASP2靶向siRNA)由Agilent(制造商目录#QPI-1007；批次#：Q02F08002N)提供。

测试材料的说明：CASP2_4_S510：S-反向-脱碱基5′-帽，L-DNA18/AS-AL。含有反向-脱碱基5′-帽、正义链位点18的L-DNA和反义链位点2、4、6、8、11、13、15和19的交替2’-OMe的一个19个碱基长度的稳定双链RNA。

储存条件：-80℃

PBS中配制siRNA：PBS中的33.3mg/ml CASP2_4_S510(滴眼剂溶液)-

测试材料的说明：在无菌条件下，将300mg干的CASP2_4_S510siRNA溶解于15ml无菌双蒸水中，以得到一清晰的20mg/ml的溶液。将该溶液储存在-80℃下，待用。然后DDW中的20mg/ml原溶液在PBS中采用100μg/3μl的工作浓度，情况如下：

1.7mg CASP2_4_S510 siRNA：85μl 20mg/ml的CASP2_4(1.7mg)原液，通过0.15M NaCl和乙醇而沉淀并在组织培养层(无菌条件下)干燥。

siRNA溶液33.3mg/ml：将1.7mg干的siRNA溶解于PBSx1中，以得到51μl。

配制的量：每管1.7mg/51μl PBS。储存条件：重新配制。

市售润滑油溶液

中配制的siRNA：33.3mg/mlCASP2_4_S510的Systane溶液(滴眼剂溶液)-组II。购自Alcone Inc.；批次#：Lot 165228F。

测试材料的说明：在无菌条件下，将300mg干的CASP2_4_S510siRNA溶解于15ml无菌双蒸水中，以得到一清晰的20mg/ml的溶液。将该溶液储存在-80℃下，待用。然后DDW中的20mg/ml原溶液在PBS中采用100μg/3μl的工作浓度，情况如下：

1.7mg CASP2_4_S510siRNA：85μl 20mg/ml的CASP2_4(1.7mg)原料，通过0.15M NaCl和乙醇而沉淀并在组织培养层(无菌条件下)干燥。

siRNA溶液33.3mg/ml：将1.7mg干的siRNA溶解于51μl的市售润滑油溶液(即)中。

配制的量：每小瓶1.7mg siRNA/51μL

溶液。

丙三醇+EDTA溶液及甲基纤维素(MC)溶液中配制的siRNA：丙三醇+EDTA制剂及0.5％、2％或3％(w/v)甲基纤维素及1％(v/v)无菌丙三醇及无热原水中0.01％(w/v)EDTA溶液中的CASP2_4_S510siRNA的33.3mg/ml溶液组-III-VI。

测试材料的说明：在无菌条件下，将300mg CASP2_4_S510粉末(Aligent，批次#Q02F08002N)溶解于15ml无菌双蒸水中，以得到一清晰的20mg/ml的溶液。将该溶液储存在-80℃下，待用。然后DDW中的20mg/ml原溶液在PBS中采用100μg/3μl的工作浓度，情况如下：

7个小瓶的1.7mg CASP2_4_S510 siRNA：85μl 20mg/ml的CASP2_4_S510(1.7mg)原液，通过0.15M NaCl和乙醇而沉淀并在组织培养层(无菌条件下)干燥。

组III：0.5％MC制剂：混合比为1∶7的溶液A和溶液B溶液A[将12.5μL溶液A与50μL溶液B及37.5μl注射用水混合，以得到0.5％甲基纤维素及1％v/v无菌丙三醇及无热原水中的0.01％w/v EDTA溶液(最终pH值约为7.4，渗透压类似于人类泪膜)]

0.5％MC制剂中配制的33.3mg/ml siRNA，将1.7mg干的siRNA溶解于所述配制的0.5％MC制剂中，以得到一51μL siRNA配制溶液的0.5％MC制剂。

组III：1％MC制剂：混合比为1∶3的溶液A和溶液B溶液A[将25μL溶液A与50μL溶液B及25μl注射用水混合，以得到1％甲基纤维素及1％v/v无菌丙三醇及无热原水中的0.01％w/v EDTA溶液(最终pH值约为7.4，渗透压类似于人类泪膜)]

1％MC制剂中配制的33.3mg/ml siRNA，将1.7mg干的siRNA溶解于所述配制的1％MC制剂中，以得到一51μL siRNA配制溶液的1％MC制剂。

组V：2％MC制剂：混合比为1∶1的溶液A和溶液B溶液A[将50μL溶液A与50μL溶液B混合，以得到2％甲基纤维素及1％v/v无菌丙三醇及无热原水中的0.01％w/v EDTA溶液(最终pH值约为7.4，渗透压类似于人类泪膜)]

2％MC制剂中配制的33.3mg/ml siRNA，将1.7mg干的siRNA溶解于所述配制的2％MC制剂中，以得到一51μL siRNA配制溶液的2％MC制剂。

组VI：3％MC制剂：混合比为1∶1的溶液A和溶液B溶液A[将50μL溶液A与50μL溶液C混合，以得到3％甲基纤维素及1％v/v无菌丙三醇及无热原水中的0.01％w/v EDTA溶液(最终pH值约为7.4，渗透压类似于人类泪膜)]

3％MC制剂中配制的33.3mg/ml siRNA，将1.7mg干的siRNA溶解于所述配制的3％MC制剂中，以得到一51μL siRNA配制溶液的4％MC制剂。

组VII：3％MC制剂：混合比为1∶1的溶液A和溶液B溶液A[将50μL溶液A与50μL溶液C混合，以得到3％甲基纤维素及1％v/v无菌丙三醇及无热原水中的0.01％w/v EDTA溶液(最终pH值约为7.4，渗透压类似于人类泪膜)]

33.3mg/ml丙三醇+EDTA制剂中配制的siRNA溶液：将1.7mg干的siRNA溶解于所述配制的丙三醇+EDTA制剂中，以得到一51μLsiRNA配制溶液的丙三醇+EDTA制剂。

配制的量：7个小瓶，如下：

1小瓶1.7mg siRNA的51μLPBS制剂

1小瓶1.7mg siRNA的制剂

1小瓶1.7mg siRNA的0.5％MC制剂

1小瓶1.7mg siRNA的1％MC制剂

1小瓶1.7mg siRNA的2％MC制剂

1小瓶1.7mg siRNA的3％MC制剂

1小瓶1.7mg siRNA的丙三醇+EDTA制剂

储存条件：重新制得

对照物

1.PBS-由Biological industries提供(制造商目录#02-023-5A(10x PBS)；批次#619113).

2.-市售滴眼剂溶液；由Alcon提供；批次#：Lot165228F；供应量：15ml；储存条件：RT；有效日期：02/2011。

制剂溶液A-无热原水溶液A中的甲基纤维素溶液)将0.4g甲基纤维素25(ScienceLab.com，Cat#SLM2050)溶解于终体积为10ml的热开水(80-90℃)，(Norbrook)中，冷却至室温。

制剂溶液B-无热原水溶液B中的无菌丙三醇+EDTA溶液)9.666ml WFI(Norbrook)中332μl的60％丙三醇(Sigma，Cat#G6279)和2μlEDTA溶液pH8(得自Sigma，Cat#E9884)。

制剂溶液C-无热原水溶液C中的浓缩甲基纤维素溶液)将0.6g甲基纤维素25(ScienceLab.com，Cat#SLM2050)溶解于终体积为10ml的热开水(80-90℃)，(Norbrook)中，冷却至室温。

上述甲基纤维素制剂中siRNA化合物的稳定性测试：

根据以下操作规程在甲基纤维素中对Casp2_4 Q02F08002NsiRNA的稳定性进行测试：

将siRNA在含甲基纤维素的不同制剂中稀释为最终浓度为7μM的siRNA。0％、将0.5％、1％、2％和3％MC制剂在室温下培养。此外，3％MC制剂也在37℃下(含或不含核酸酶抑制剂)培养。

在以下时间点：0、10’、0.5、1、1.5、3、6h培养后，将每个溶液的5-μL小份转移到15μL的10x TBE负载缓冲剂中。然后，将该溶液在液氮中冷冻，并储存在-20℃下。

将每个样品的4μL负载到非变性20％聚丙烯酰胺凝胶上，并在80V下电泳2.5小时。

对于siRNA可视化，用溴化乙锭溶液(1.0μg/μL)对凝胶进行染色。

至于非降解siRNA凝胶迁移的阳性对照，将PBS中5μL的7μM测试siRNA溶液转移到15μL的10x TBE负载缓冲剂中，并负载到凝胶上。然后，将该溶液在液氮中冷冻，并储存在-20℃下。

作为降解单链siRNA的迁移模型的参考，对非相关单链siRNA进行了制备。

结果：Casp 2_4siRNA在所有制剂中是稳定的。

体内研究：

测试系统：

所用的动物：大鼠；属：成年，Sprague-Dawley；修饰：SD

来源：Harlan，Jerusalem Israel

年龄：8-10周；体重范围：220-270g

性别：雄性；组大小：n＝6；动物总数：54

畜牧业：饮食：向动物提供任意的市售啮齿动物食物，并能自由获得饮用水。

环境：

(i)至少5天的驯化。

(ii)在整个研究期间，将所有动物关在一个控制居住条件的专用设施中，并根据规定的操作规程(SOP)维持不变。向动物提供任意的市售啮齿动物食物(rlan Teklad 2018S总量含18％蛋白质的啮齿动物食物)和过滤、加氯消过毒的酸化水。

在整个研究期间，将大鼠关在含有过滤器顶部的微型隔离器笼子中，1-6大鼠/笼。将笼子维持在受控制的环境下，温度条件(20-24℃)，相对湿度(30-70％)，12-小时光照/12小时黑暗的周期，由控制计算机监控。

实验设计

实验设置包括9个实验组(每组6只大鼠)。将滴眼剂双侧给药。使用了不同的制剂(研究设计表C11)。在siRNA给药后的终止时间点(3小时)：终止设置根据表C11的研究设计施行。CASP2_4siRNA的视网膜浓度通过定量PCR测定。

表C11：研究设计

^＊丙三醇+EDTA制剂(不含MC的制剂)＝1％v/v无菌丙三醇及无热原水的0.01％w/v EDTA溶液

麻醉：在实验过程中，所有滴眼剂治疗的动物都用Equithesine(I.P.4ml/kg)麻醉。

滴眼剂传输：使用钝吸管端(10μl无菌过滤嘴(短))将测试物或载体的3μL样品量施用到麻醉动物的双侧角膜表面。将该动物安置于温暖的环境中，以防止麻醉引起的低体温。根据研究设计(时间点3小时)终止所有研究小组的动物。根据研究设计收集组织。

预定的安乐死：将所有动物深度麻醉，并根据研究设计对各组小鼠施行安乐死(表C11，终止)。

灌注计划：用PBS对大鼠经心脏进行灌胃(在2-3分钟后20-50ml/min)。

组织收集：灌注后，摘除双眼(左，右)的细胞核，储存于冰中。用双筒显微镜解剖眼睛，并根据样品分级标准选择总病理学分级。沿角膜缘切开角膜，轻轻取出晶状体，小心翼翼地将玻璃体及视网膜与巩膜分离。收集全视网膜及玻璃体(humor)，独立适当地分成两份，并适当地标记试管。用大量的PBS清洗解剖的视网膜(新配制PBS单独管中的每一个视网膜)，用

除去多余的液体，在液氮下捕捉冷冻视网膜。对视网膜和玻璃体样品进行了RNA提取。

评价：

RNA提取：视网膜：通过双提取分别从每个视网膜样品(左和右)中提取RNA。对RNA进行cDNA制备和定量PCR分析。

玻璃体：使用以下操作规程获得从玻璃体检测Casp2_4_S510siRNA的材料：每个大鼠玻璃体约为10μl。将500μl试剂AEZ-RNA(Biological Industries Cat no.20-410-100)添加到每个玻璃体中。样品经均质化后，添加10μgtRNA(10mg/m原液的1μl)。将该样品储存在室温下5分钟。随后，分别加入EZ-RNA II B：400μl和EZ-RNA II C：90μ，并混匀。将该样品储存在室温下10分钟，然后在4℃、12000g下离心15分钟。

将上相转移到一个异丙醇的500μl新管中，添加线性丙烯酰胺5μl。将该样品储存在-20℃下过夜，在4℃、12000g下离心20分钟，用75％乙醇洗涤两次。将颗粒溶解于15μl水中。

siRNA的量化：根据Quark标准操作规程进行定量PCR分析，对视网膜和玻璃体液中siRNA的量(siRNA的量化通过每玻璃体施行)进行测定。

结果

研究表明，在无创伤性地向体内施用不同制剂3小时后，在大鼠视网膜内检测到下列的许多siRNA：

表C12：fmle/1μg RNA中的CASP2 siRNA标准化(miRNA)数量

组	简写	N	平均值	标准差
					IX	I-N/A	6	0.005	0.005
VIII	P-PBS	6	0.056	0.124
					VII	C-MC(0)	6	6.303	3.921
XA	C-MC(1/2)	4	17.831	16.628
					XIA	C-MC(1)	6	5.677	4.235
V	C-MC(2)	6	6.963	8.042
					VI	C-MC(3)	5	7.653	6.674
II	C-Systane	5	5.109	2.492
					I	C-PBS	6	4.228	6.758

MC(0)-MC(3)-包括0至3％不断增加甲基纤维素浓度的制剂。

结论：所有通过CASP2 siRNA治疗组显示目标视网膜组织中siRNA(＞4fmole)的阳性数量。制剂组之间没发现显着差异(P值＝0.8425)。

无创伤性给药的siRNA诱导与目标眼部细胞的细胞凋亡相关的目标基因的体内抑制(KD)

实施例8：通过滴眼剂在大鼠视网膜内给药的p53基因靶向siRNA体内抑制活性的测定，MC 2％中配制的siRNA化合物(制剂“A”)

目的

这项研究的目的是为了测定无创伤性给药的siRNA化合物靶向p53mRNA在大鼠神经视网膜中的抑制活性。siRNA化合物被配制为通过滴眼剂给药。通过采用ELISA法测定蛋白水平评价抑制活性。

测试物

a.物质(未配制的化合物)：QM5(小鼠/大鼠p53靶向siRNA)

b.无创伤性(滴眼剂)传输的配制siRNA化合物(表C13中的组2和5)：在2％(w/v)甲基纤维素及1％(v/v)无菌丙三醇及无热原水(滴眼剂溶液)中0.01％(w/v)EDTA溶液中的100μg/3μQM5siRNA溶液。

c.玻璃体内注射的配制siRNA化合物(表C13中的组1和4)140μl PBS中的280μg QM5siRNA

d.无创伤性(滴眼剂)传输的配制载体溶液(表C13中的组3和6)：2％(w/v)甲基纤维素及1％(v/v)无菌丙三醇及无热原水(滴眼剂溶液)中的0.01％(w/v)EDTA溶液。

测试系统：

成年雄性，Sprague-Dawley(SD)大鼠Harlan，Jerusalem Israel，，6-8周龄，每个160-180g。

实验设计

研究设计：对组1-6的每个动物进行单侧切断(左眼，OS)。

组2、3、5和6：将测试化合物(3μl配制载体中的100μg测试物-组2及5)或配制载体单独(组3和6)从0天(切断后立即)开始作为每天的滴眼剂。根据表C13终止实验组。组7的左眼和右眼样品作为一个完整的正常对照。

组1和4：切断(0天)三分钟后，将10μL PBS中的20μg siRNA化合物通过显微注射入玻璃体内。使用胰岛素微型注射器(0.3ml)对玻璃体进行的显微注射垂直于巩膜。根据表C13终止动物。

表C13：研究设计

(见下表C14-C17和图11A和11B)

根据肾脏W.C.E标准曲线的p53信号

表C14：根据肾脏W.C.E标准曲线的p53信号值

表C15：未处理动物的p53信号比％

根据GST-hp53的p53信号

表C16：根据GST-hp53标准曲线的的p53信号值

表C17：未处理动物的p53信号比％

结论：这些研究表明：大鼠神经视网膜内无创伤性给药的siRNA化合物靶向p53mRNA诱导了p53蛋白的抑制。

siRNA化合物诱导眼神经损伤动物模型中的体内眼神经保护作用

实施例9：在IVT注射后通过ONC模型中siRNA化合物靶向蛋白酶2诱导的眼神经保护作用的评价

研究目标：是为了评价IVT注射后ONC模型中siRNA化合物靶向蛋白酶2的眼部神经保护功效

方法

RGC的逆行标记

将荧光金示踪物沿着视网膜神经节细胞轴突逆行传输(从脑到眼)，导致所有RGC形成完整和特定的标签。为了本研究的目的，通过应用逆行示踪物荧光金(2％，荧光染料，Englewood，CO)对所有RGC进行标记。简单地说，在头皮上方离囟喙6mm和两半球中线外侧1.2mm的坐标处钻个窗口。使用微量注射器，将3μL荧光金以1μl/min的速率向骨表面下方3.8mm，4mm和4.2mm处这三个深度注入上丘。然后将该针慢慢取回，缝合皮肤。在成年大鼠中，根据这个步骤得到所有RGC全部标记所需的时间为～1周。出于这个原因，在RGC逆行标记后一周，施行ONC。

视神经损伤：麻醉成年大鼠的眼窝视神经(ON)显露是通过眼眶路径、切断的脑膜以及通过使用钳子10秒内将筛状板压碎成2mm的横断ON的所有轴突。

玻璃体内(IVT)注射。使用微量吸液管将一个或两个20μg剂量(在10μL的PBS内)的测试或对照siRNA或10μL PBS载体显微注射到神经头2mm前的玻璃体内，并垂直于巩膜。IVT给药被认为是对照或目标基因的初步验证。

存活的视网膜神经节细胞的量化。在终止时，使用4％多聚甲醛对实验动物经心脏进行灌注。将含有视神经的眼睛摘除细胞核，用刀片切开角膜，轻轻取出晶状体/玻璃体。将两个视网膜解剖出来，固定另外30分钟，将玻璃体平面倒置安装在神经节细胞层测试的载玻片上。在荧光显微镜和紫外线过滤器(365/420nm)下对RGC进行测定。通过两个不同的，独立的“盲”研究者在16个不同区域计数对逆行荧光RGC的数量进行测定(视网膜半径中六分之一、二分之一、六分之五这3个不同的偏心率对应每视网膜象的四个区域)。在死亡的RGC吞噬后，可能纳入荧光金的小胶质细胞是以典型的形态为特征，并不能进行定量分析。

部分1

测试物：CASP2_4siRNA-一个通过2’O-甲基化在其两条链是化学修饰的具有19个碱基长度的寡核苷酸双链。其他化合物包括使用正义链3’末端的L-DNA或3’末端的2’5’桥是化学修饰的siRNA。多物种中的蛋白酶2目标基因。

对照物：PBS

设计：通过将逆行示踪物荧光金应用到上丘上对视网膜神经节细胞(RGC)首先进行选择性地标记。一个星期后，动物受到视神经挤压伤(ONC)。在通过平面安装视网膜上荧光金标记的RGC计数的ONC后7和30天，对存活RGC进行量化，表C18的显示了组治疗。

表C18：组治疗

结果：使用20μg Casp2_4 siRNA治疗的眼睛的存活RGC的平均数，经视神经损伤后7天为2040±35个细胞/mm²，30天为298±25个细胞/mm²。这些计数均显著大于经PBS处理的眼睛RGC的平均计数，7天为941±27个细胞/mm²，30天为41±7个细胞/mm²。在非手术对照眼中，RGC平均数为2253±104个细胞/mm²，相当于文献中报道的RGC平均数。表C19提供了这项研究的结果。

表C19：在伤后不同时间点的存活视网膜神经节细胞平均数

给出了平均值±标准偏差的所有数据。采用单向方差分析(ANOVA)对值进行比较，并在P＜0.02时被认为是显著差异。

结论：视网膜神经节细胞增加的存活并不是由于麻醉(氯胺酮是N-甲基-D-天冬氨酸受体的拮抗剂，二甲苯胺噻嗪是2-肾上腺素受体激动剂)的神经保护作用，因为对照组中的相同麻醉动物的视网膜神经节细胞计数，显著低于Casp2_4siRNA治疗组中的动物，但却是由于在通过siRNA化合物靶向蛋白酶2基因治疗的视神经损伤后沉默促凋亡蛋白酶2激活和上调的神经保护作用。

部分2

测试物：CASP2_4siRNA-一个通过反义链2’O-甲基化和正义链的L-DNA进行化学修饰的具有19个碱基长度的寡核苷酸双链。许多物种的目标蛋白酶2基因。

对照物：

-PBS

-siRNA靶向GFP-一个通过2’O-甲基化在其两条链进行化学修饰的具有21个碱基长度的寡核苷酸双链。

-CNL-与任何已知的哺乳动物转录物没有配对的siRNA；一个通过2’O-甲基化在其两条链进行化学修饰的具有19个碱基长度的寡核苷酸双链。

设计：通过将逆行示踪物荧光金应用到上丘上对视网膜神经节细胞(RGC)首先进行选择性地标记。一个星期后，动物受到视神经挤损伤(ONC)。在通过平面安装视网膜上荧光金标记的RGC计数的ONC后7天，对存活RGC进行量化，表C18的显示了组治疗。在ONC时，对测试或对照物进行注射。为了测试通过滴眼剂给药(见下例)的siRNA的活性和功效，进行了类似的实验。表C20显示了组治疗。

表C20：组治疗

结果：使用20μg Casp2_4siRNA治疗的眼睛的存活RGC的平均数，经视神经损伤后7天为2040±35个细胞/mm²。这些计数均显著大于经PBS或GFP siRNA或CNL_1 siRNA处理的眼睛RGC的平均计数，经视神经损伤后7天分别为901±50个细胞/mm²、922±38个细胞/mm²、898±42个细胞/mm²。在非手术对照眼中，RGC平均数为2196±110个细胞/mm²，相当于文献中报道的RGC平均数。表C21显示了该结果。给出了平均值±标准偏差的所有数据。采用单向方差分析(ANOVA)对值进行比较，并在P＜0.01时被认为是显著差异。

表C21：在伤后7天存活RGC的平均数(n＝4视网膜/组).

节细胞存活的增加是由于在通过siRNA化合物靶向蛋白酶2基因治疗的视神经损伤后沉默促凋亡蛋白酶2激活和上调的神经保护作用。含有不同结构修饰/基序的Casp2_4 siRNA分子显示了视网膜神经节细胞存活范围的神经保护功效。

实施例10：IOP模型中siRNA化合物靶向蛋白酶2的眼部神经保护功效的评价

本次研究的目的是要建立在临床前大鼠青光眼IOP模型中单次注射20μgCASP2_4化合物或阴性对照GFP siRNA的神经保护功效。

研究概述

在研究小组的所有动物中，将荧光示踪DiI(1，1′-双十八烷基-3，3，3′，3′-四甲基吲哚碳菁)应用到两个上丘对视网膜神经节细胞进行逆行标记。一个星期后，组2至5动物的左眼眼压单方面地增加。在2个星期内，每隔一天监测手术(左)眼和对侧(右)眼的眼压。在注射高渗盐水两星期后，将载体(PBS)或siRNA(PBS中的20μg，siRNA靶向Casp2或阴性对照siRNA siRNA靶向非哺乳动物基因，绿色荧光蛋白)，通过玻璃体内(IVT)注射到左(手术)眼中。对侧的非手术眼没有进行IVT注射。此外，在注射高渗盐水两星期后，将组2动物处死，在荧光显微镜下对DiI标记RGC进行计数，以评价在siRNA注射时RGC的缺失程度。对于接受IVT注射的所有组，在实验的第三周期间对IOP测量一次，以确认在手术眼增加的状态。在IOP增加3周时，或在测试和对照物注射后1周，将这些动物处死，在荧光显微镜下对DiI标记RGC进行计数。右视网膜作为标签质量的内部对照。实验一开始对其RGC进行逆行标记的一单独组的原生大鼠，被用作完整对照，以提供正常RGC密度的参考。在高眼压症2周时将这组4只大鼠处死(连同第2组)，剩余9只在3周时(连同组3至5)处死。实验设计见下表C22。

表C22动物

材料和设备物质

(未配制的化合物)CASP2_4_S510(CASP2_4；CASP2 SIRNA；siRNA靶向半胱天冬酶2mRNA)

由Agilent提供

测试材料的说明：一个19个碱基长度的化学修饰钝端双螺旋结构含具有两个独立链，其中，包括未修饰核糖核苷酸(大写字母)、位点18的L-脱氧核糖核苷酸(粗体，下划线)和SEN链5′末端的反向脱氧脱碱基(IB)的正义链(SEN)，以及包括未修饰核糖核苷酸(大写字母)和式I所述位点2、4、6、8、11、13、15、17和19的2’OMe糖基修饰核糖核苷酸(小写字母)的反义链(AS)。

供应量：300mg

储存条件：-80℃

对照物(未配制的化合物)GFP_5_S763(siRNA靶向GFPmRNA)

外购(制造商名称)：Agilent

制造商目录#N/A

供应量：220.8150mg

储存条件：-80℃；到期日：ND

测试/对照物(配制的)CASP2_4/GFP_5 20μg/5μL PBS

将0.5mg溶解于125μl以得到一4μg/μl的原液。随后将其分装入5μl的管中，并储存在-80℃下。

载体-PBS

多单元磷酸盐缓冲生理盐水，溶液1X，没有钙，也没有镁(目录编号：311-010-EL)。

将荧光显微镜和Zeiss Axioskop 2Plu显微镜(Carl Zeiss Canada，Kirkland，QC)一起操作使用，使用电荷耦合摄像机(Retiga，Qimaging)拍摄图像，并用Northern Eclipse图像分析软件(Empix Imaging，Mississauga，ON)对其进行处理。将缩影影片放大拍摄25倍。

实验步骤

对成年雄性棕色挪威鼠进行手术，不育种，年龄介于10-12个月间(300-400g)，在全身麻醉下，通过由氯胺酮(100mg/mL)、甲苯噻嗪(20mg/mL)和乙酰丙嗪(10mg/mL)组成的1mL/Kg标准大鼠鸡尾酒的进行腹腔内注射。

高眼压症手术：通过使用Morrison模型诱导单侧慢性高IOP，涉及到将高渗盐水注射入巩膜静脉中，从而导致房水外流途径的阻塞。此过程导致眼压的逐渐增加，和RGS的逐步死亡。对这项研究中的所有动物，只进行单一盐水静脉注射。该步骤所选定的眼睛是与应用到眼球赤道的塑料环相适应的，以限制盐水注射到角膜缘。使用微型针(直径30-50μm)将50μL无菌NaCl溶液(1.85M)注入一巩膜静脉中。塑料环暂时封堵了将生理盐水压入巩膜静脉窦的其他巩膜静脉，以隔离疤痕。将动物关在一个恒定的低荧光灯(40-100lux)室内，以稳定昼夜眼压变化(8)。

眼内压(IOP)的测量：使用一个校准眼压计(TonoPenXL，Medotronic Solan，Jacksonville，FL)在清醒动物中测量青光眼和正常眼(对侧眼)的IOP。在高眼压症手术后前两周，每隔一天对IOP进行测量；在高眼压症手术后第2周和第3周之间至少一次。在高眼压条件下眼内注射后，眼睛变得脆弱，为此IOP测量次数是有限的，因为这涉及到将在角膜上的附加压力，以得到确实的读数。由于压力升高的发病，每只眼的平均IOP(毫米汞柱±标准差)被认为是为所有IOP读数的平均值。每个人眼睛的最高IOP，青光眼或正常对侧眼图测量定义为IOP高峰值，这个值被用来估计每个组的平均IOP峰值。

眼内压(IOP)的测量：由于压力升高的发病，每只眼的平均IOP(毫米汞柱±标准差)被认为是为所有IOP读数的平均值。每个人眼睛的最高IOP，青光眼或正常对侧眼图测量定义为IOP高峰值，这个值被用来估计每个组的平均IOP峰值。正整数IOP是根据青光眼减去从高眼压症手术到安乐死的正常眼的IOP曲线围成的面积。整数IOP表示的是在整个实验中，全部累积的IOP接触。

研究设计：

在诱导青光眼一周前，将荧光示踪DiI应用到两个上丘对RGC进行逆行标记。

一周后，IOP的单方面升高是通过将高渗盐溶液注射到巩膜静脉诱导的。此过程被称为高眼压手术。

在第一个实验中，药效研究前，在高眼压症手术后2周和3周，对“没有注射”组的RGC缺失状态(4只大鼠/组，总量＝8只大鼠)进行了评价。

在高眼压症手术后整整2周，进行每个siRNA的单一玻璃体内注射。

在高眼压症手术后整整3周，对动物施行安乐死，并制备RGC存活分析的视网膜。在12个标准视网膜区域中量化存活RGC的密度

表C22：研究设计

^＊NA-未施用，组大小：n＝5

存活RGC体的量化：以复制和掩蔽的形式对存活RGC体进行量化。RGC密度计数，通过大鼠进行深度麻醉，然后用4％多聚甲醛(PFA)以0.1M磷酸缓冲剂经心脏进行灌注，之后将两只眼睛的细胞核立即摘除。将视网膜解剖出来，并将倒置的神经节细胞层平面安装在载玻片上。在荧光显微镜下对所述DiI标记神经细胞的12个标准视网膜区域进行计数。

结果与讨论

表C23：完整推论表的视网膜神经节细胞百分比

处理	N	平均值	Std	CV	Dunnett P-值
						PBS	6	62.37	5.86	9.40
CASP24	6	81.71	14.28	17.48	0.05
						2wIOP	4	71.25	6.75	9.47	0.19
GFPsiRNA	6	65.75	4.97	7.57	0.68
						完整的	13	100.00	2.84	2.84	0.00

PBS治疗组的比较

CASP2_4siRNA-治疗的IOP升高的眼睛RGC防腐显著优于PBS处理组(比PBS结果高于1.31倍；p值＝0.05)。在绿色荧光蛋白siRNA治疗组中，至于PBS治疗组中没有发现显著差异(p值＝0.68)。

PBS(p值＝0.19)处理的IOP(2周)至IOP(3周)之间没有显著差异。

IOP(2周)组的比较

该完整组每mm2的RGC密度显著高大于IOP(2周)组(p值＝0.00)。IOP(2周)组和3周后将被处死的其他组(p值范围为0.16至0.44)之间的每mm²的RGC密度没有显著差异。

完整组的比较

该完整组每mm2的RGC密度显著高大于PBS、GFP siRNA治疗的IOP组和未治疗的IOP(2周)组(p值＜0.01)。与完整组(p值＝0.06)相比，CASP2_4siRNA治疗的IOP组间的每mm2的RGC密度没有显著差异。

这些数据表明，siRNA靶向半胱天冬酶2对IOP升高引起的RGC损伤提供保护，其IOP升高2周时的给药导致IOP进一步缺失的停止。

如上所述进行IOP测量。

IOP：Dunnett方法是用于PBS治疗组的结果比较。对另外的参数进行了计算和分析，如：AUC(曲线下面积)，在整个测量时间内的平均IOP和最高(IOP)。

大多数动物在高眼压手术1-2周后显示了IOP的显著增加。

在治疗组的手术眼(0.7746)之间没有发现显著的IOP水平差异。同样地，在IOP水平无差异，在治疗组的对侧眼和完整眼之间没有发现IOP水平差异。

结果表明，正当所有治疗组中的IOP保持升高时的Casp2 siRNA诱导的神经保护作用。

结果：在所有三个计算IOP参数的组之间没有发现显著差异。

实施例11：切断模型中siRNA化合物靶向半胱天冬酶2的神经保护功效的评价

本功效研究的目的是在成年Sprague-Dawley大鼠中使用视神经(ON)损伤诱导的RGC凋亡模型。这个模型系统中RGC死亡的发生和动力学的重现性非常好，并考虑到建立体内Casp2_4siRNA的神经保护功效。使用这种方法，RGC死亡随时间的变化遵循一个可预测的过程：细胞死亡从第5天开始，并继续下去到2周后，这些神经细胞超过90％的迅速丧失。

方法

RGC逆行标记：为了本研究的目的，通过应用逆行示踪物荧光金(2％，荧光染料，Englewood，CO)对所有RGC进行标记。简单地说，将两个上丘露出，将浸润有荧光金一小块明胶海绵应用于其表面。在成年大鼠中，根据这个步骤得到所有RGC全部标记所需的时间为～1周。出于这个原因，在RGC逆行标记后一周，对其进行视神经切断和siRNA眼内注射。

视神经切断：通过横断靠近眼睛(0.5至1mm)的视神经对RGC的整个种群进行切断。在每次切断术后，进行常规的视网膜眼底检测，以检查手术后视网膜循环的完整性。动物表现出缺乏免疫力的血液供应迹象不属于本研究的范围。

对于玻璃体内注射，在手术时第0天使用玻璃微量吸液管将10μgl的每个5μl PBS试剂、Casp2_4siRNA或siRNA显微注射入玻璃体内神经头前2mm，并垂直于巩膜，然后第7天重复。

存活RGC的量化：在视神经切断后14天，用4％多聚甲醛对实验和对照动物经心脏进行灌注。将左视网膜(处理)和右视网膜(未经治疗的对照组)解剖出来，固定另外30分钟，将玻璃体平面倒置安装在RGC层测试的载玻片上。对12个标准区域内回填有荧光金的RGC进行计数。在死亡的RGC吞噬后，可能纳入荧光金的小胶质细胞是以典型的形态为特征，并不能进行定量分析。

实验设计

测试物：CASP2_4LsiRNA-一个通过反义链2’O-甲基化和正义链的L-DNA进行化学修饰的具有19个碱基长度的寡核苷酸双链。

对照物

PBS

-siRNA靶向GFP-一个通过2’O-甲基化在其两条链进行化学修饰的具有21个碱基长度的寡核苷酸双链。

-CNL-与任何已知的哺乳动物转录物没有配对的siRNA；一个通过2’O-甲基化在其两条链进行化学修饰的具有19个碱基长度的寡核苷酸双链。表C24显示了组治疗。

表C24：组治疗

结果：使用10μg Casp2_4siRNA治疗的眼睛的存活RGC的平均数，经视神经损伤后30天为533±24个细胞/mm²。这些计数均显著大于经PBS治疗的眼睛RGC的平均计数，其在30天为130±7个细胞/mm²。在非手术对照眼中，RGC平均数为2138±91个细胞/mm²，相当于文献中报道的RGC平均数。

表C25：伤后14天RGC存活的平均数(n＝6例视网膜/组)

治疗	GFP	Casp24
			RGC存活平均值(细胞/mm2)	130	533
SE	7	24
			全部RGC中的RGC存活％	6	25
SE	0.32	1.12

使用单向方差分析(ANOVA)的GraphPad Instat软件对进行数据分析和统计。给出了平均值±标准偏差的所有数据，并在P＜0.02时被认为是显著差异。

结论：RGC存活的增加是由于通过siRNA化合物靶向半胱天冬酶2基因治疗的视神经损伤后沉默促凋亡半胱天冬酶2激活和上调的神经保护作用。

结论：在本研究中，Casp2_4 siRNA在视神经损伤模型中的神经保护至少为30天，在RGC缺失的切断模型中神经保护为14天。视神经损伤和切断实验提供了急性视神经病的逼真模型。

siRNA化合物的无创伤性给药诱导眼神经细胞损伤动物模型中的体内眼神经保护作用

实施例12：ONC模型中无创伤性给药的siRNA靶向半胱天冬酶2的眼神经保护功效的评价

测试物：CASP2_4siRNA(式I化合物)

对照物：

-甲基纤维素

-CNL-与任何已知的哺乳动物转录物没有配对的siRNA；一个通过2’O-甲基化在其两条链进行化学修饰的具有19个碱基长度的寡核苷酸双链。

设计：通过将逆行示踪物荧光金应用到上丘上对视网膜神经节细胞(RGC)首先进行选择性地标记。一周后，动物受到视神经损伤(ONC)。一周内每隔一天施用滴眼剂(总共3次)，施用100μg/3μl CNL_1或Casp2_4 siRNA或3μl的MC载体，在ONC后10分钟施用第一剂量。在通过平面安装视网膜上荧光金标记RGC计数的ONC后7天，对存活RGC进行量化。

结果：使用20μg Casp2_4 siRNA治疗的眼睛的存活RGC的平均数，经损伤后7天为445±17个细胞/mm²。这些计数均显著大于经PBS或CNL_1siRNA处理的眼睛RGC的平均计数，其在7天分别为337±11个细胞/mm²和341.6±13个细胞/mm²。表C26显示了该结果。给出了平均值±标准偏差的所有数据。使用单向方差分析(ANOVA)进行数据分析和统计，并在P＜0.01时被认为是显著差异。

表C26：在伤后第7天存活RGC的平均数

	CNL_1	Casp2_4	MC载体
				平均值	341.625	445.4375	337.5
标准偏差	13.03265	17.222331	11.3389342
				细胞/mm2	934.6785	1218.7073	923.392613
Sd	35.65705	47.119921	31.0230758
RGC/视网膜	26470.1	34513.789	26150.4788
				标准偏差	1009.808	1334.4362	878.573505
				％总数	26.4701	34.513789	26.1504788
标准偏差	1.009808	1.3344362	0.87857351
				平均值	341.625	445.4375	337.5
标准偏差	13.03265	17.222331	11.3389342

结论：RGC存活的增加是由于通过甲基纤维素制剂中含siRNA靶向半胱天冬酶2基因的滴眼剂治疗的ONC损伤后沉默促凋亡半胱天冬酶2的神经保护作用。

实施例13：IOP模型中无创伤性给药的siRNA靶向半胱天冬酶2的眼神经保护功效的评价

实验设置：

实验动物：根据加拿大议会关于实验动物使用的指导施行所有动物的步骤(http://www.ccac.ca/)。对成年雄性棕色挪威鼠进行手术，不育种，年龄介于10-12个月间(300-400g)，在全身麻醉下，通过由氯胺酮(100mg/mL)、甲苯噻嗪(20mg/mL)和乙酰丙嗪(10mg/mL)组成的1mL/Kg标准大鼠鸡尾酒进行腹腔内注射。

RGC逆行标记：对于神经细胞的存活实验，使用3％的荧光染料DiI(1，1′-双十八基-3，3，3’，3’-四甲基-吲哚碳菁高氯酸酯；MolecularProbes，Junction City，OR)对RGC进行逆行标记，荧光碳菁标记持续数个月不褪色或渗漏，并不影响标记细胞的功能。对于逆行标记，将两个上丘，大脑中RGC的主要目标，与外界接触，将浸润有DiI的一小块明胶海绵(Pharmacia and Upjohn Inc.，Mississauga，ON)应用于其表面上。DiI应用7天后，标记所有RGC所需的时间，如下所述动物经过高眼压手术。

高眼压症手术：通过使用一种方法诱导单侧慢性高IOP，涉及到将高渗盐水注射入巩膜静脉中。对这项研究中所涉及的所有动物，只进行单一盐水静脉注射。该步骤所选定的眼睛是与应用到眼球赤道的塑料环相适应的，以限制盐水注射到角膜缘。使用微型针(直径30-50μm)将50μL无菌NaCl溶液(1.85M)注入一巩膜静脉中。塑料环暂时封堵了将生理盐水压入巩膜静脉窦的其他巩膜静脉，以隔离疤痕。将动物关在一个恒定的低荧光灯(40-100lux)室内，以稳定昼夜眼压变化(8)。

眼内压(IOP)的测量：在清醒动物中使用一个校准眼压计(TonoPen XL，Medotronic Solan，Jacksonville，FL)测量青光眼和正常眼(对侧眼)的IOP。在高眼压症手术后前两周，每隔一天对IOP进行测量；在高眼压症手术后第2周和第3周之间至少一次。在高IOP条件下(见下文)眼内注射后，眼睛变得脆弱，为此IOP测量次数是有限的，因为这涉及到将在角膜上的附加压力，以得到确实的读数。由于压力升高的发病，每只眼的平均IOP(毫米汞柱±标准差)被认为是为所有IOP读数的平均值。每个人眼睛的最高IOP，青光眼或正常对侧眼被定义为IOP高峰值，这个值被用来估计每个组的平均IOP峰值。正整数IOP是根据青光眼减去从高眼压症手术到安乐死的正常眼的IOP曲线围成的面积。整数IOP表示的是在整个实验中，全部累积的IOP测光。

siRNA分子眼内注射：通过以20μg的浓度将每个siRNA化合物灌注入左眼的玻璃体腔内进行眼内注射(全部注射量：5μl)。右眼作为对侧对照。此外，将原生大鼠的非手术眼用作完整对照。使用配备有一支32-水位玻璃针的10μl Hamilton注射器进行玻璃体内注射。将针尖插入眼睛的上半球，在玻璃体水平上，以45°角穿过巩膜进入玻璃体。这种给药途径避免视网膜脱离或损伤眼结构，其中包括晶状体和光圈，其可以释放RGC再生和存活的因子。在2分钟内进行注射，并将针保持在位置内另外2分钟后，轻轻地移除。用手术胶(IIndermill，Tyco Health Care，Mansfield，MA，USA)密封注射部位。

siRNA分子的局部滴眼剂滴注：

在诱导IOP后3周间每天，使用钝吸管端(10μl无菌过滤嘴(短))将3μl样品量的100μg siRNA施用到麻醉动物的双侧角膜表面。将这些动物安置于温暖的环境中，以防止麻醉引起的低体温。

存活RGC体的量化：以复制和掩蔽的形式对存活RGC体进行量化。RGC密度计数，通过大鼠进行深度麻醉，然后用4％多聚甲醛(PFA)以0.1 M磷酸缓冲剂经心脏进行灌注，之后将两只眼睛的细胞核立即摘除。将视网膜解剖出来，并将倒置的神经节细胞层平面安装在载玻片上。在荧光显微镜下对所述DiI标记神经细胞的12个标准视网膜区域进行计数。

诱导IOP(眼内压力)，并持续了2周。然后，将CASP2 4或对照siRNA通过滴眼剂(2％甲基纤维素制剂中的siRNA)或IVT(PBS中的siRNA)IVT施用，详见表C27的研究设计。

表C27：研究设计

^＊NA-未施用的，组大小：n＝5

结果显示，2％甲基纤维素制剂中配制的siRNA的无创伤性传输提供了神经保护作用，并增加了神经细胞的存活率。

实施例14：大鼠视神经损伤(ONC)模型：玻璃体内注射siRNA与外用滴眼剂传输的比较

对于视神经横切面，麻醉成年大鼠的眼窝视神经(ON)显露是通过眼眶路径、切断的脑膜以及通过使用钳子10秒内将筛状板压碎成2mm的横断ON的所有轴突。

siRNA化合物单独施用或与以5uL量作为滴眼剂(20ug/uL)施用。在视神经损伤后(ONC)，立即将20ug/10ul测试siRNA或10ul PBS通过IVT施用到成年大鼠的单眼或双眼上。在此之后，每隔一天将siRNA通过ED施用到眼睛上，并对所采取解剖的siRNA的水平以及在注射后5小时和1天，稍后的2天、4天、7天、14天和21天捕捉冷冻的整个视网膜进行了测定。进行类似的实验是为了测试通过滴眼剂给药的siRNA的活性和功效。

下表C28显示的实验步骤，是为了测定在ONC模型中siRNA(siTEST1；siTEST2)单独或组合使用的功效。附加的剂量参数、浓度、终止时间表、制剂等是预期的。

表C28：研究设计

结果：根据本研究所得的结果，为目标基因下调设计的siRNA化合物的无创伤性传输提供了神经保护，并增加了视网膜的神经细胞存活率。

表B1-B26披露了用于合成未修饰或化学修饰siRNA化合物的正义和反义核酸的寡核苷酸对。这些表披露了沿着mRNA fior至少一个变体的正义链位点。

表B1 ACHE-乙酰胆碱酯酶

表B2 ADRB1-肾上腺素，β-1-，受体

No.	正义链siRNA	反义链siRNA	其他Sp	人-110349783：87-1520
					1	GAGGCAAAAUAAAAAAAAA	UUUUUUUUUAUUUUGCCUC		[2094-2112]
2	GGAUGGAGGCAAAAUAAAA	UUUUAUUUUGCCUCCAUCC		[2089-2107]
					3	GGGCAGAUCUUAAAUAAAA	UUUUAUUUAAGAUCUGCCC		[2543-2561]
4	CAGUGUUAGGAAUUACAAA	UUUGUAAUUCCUAACACUG		[2463-2481]
					5	GGCAGAUCUUAAAUAAAAU	AUUUUAUUUAAGAUCUGCC		[2544-2562]
6	GAUGGAGGCAAAAUAAAAA	UUUUUAUUUUGCCUCCAUC		[2090-2108]

7	CAGAGAAAUUUCAUUUUAA	UUAAAAUGAAAUUUCUCUG		[2028-2046]
					8	GGAGGCAAAAUAAAAAAAA	UUUUUUUUAUUUUGCCUCC		[2093-2111]
9	GCCUCUUCGUCUUCUUCAA	UUGAAGAAGACGAAGAGGC	大鼠，Ms	[1156-1174]
					10	GAGAAAGGAUGGAGGCAAA	UUUGCCUCCAUCCUUUCUC		[2083-2101]
11	GGGCUGGGCAGAUCUUAAA	UUUAAGAUCUGCCCAGCCC		[2538-2556]
					12	CACGGACCGUUGCACAAAA	UUUUGUGCAACGGUCCGUG		[1655-1673]
13	GAUGUUACUUGCACAAAAA	UUUUUGUGCAAGUAACAUC		[2492-2510]
					14	GGGAAAAUACCUUUUUAUA	UAUAAAAAGGUAUUUUCCC		[2612-2630]
15	CUGGGCAGAUCUUAAAUAA	UUAUUUAAGAUCUGCCCAG		[2541-2559]
					16	GGUCCAUGUGCAAUAAAUA	UAUUUAUUGCACAUGGACC		[2826-2844]
17	CCACAAUCCUCGUCUGAAU	AUUCAGACGAGGAUUGUGG		[1614-1632]
					18	AAGGAUGGAGGCAAAAUAA	UUAUUUUGCCUCCAUCCUU		[2087-2105]
19	AGAUGUUACUUGCACAAAA	UUUUGUGCAAGUAACAUCU		[2491-2509]
					20	GACAGUUUGUCAAGACAUA	UAUGUCUUGACAAACUGUC		[1994-2012]
21	CCUUUAUCAUGGUACUGUA	UACAGUACCAUGAUAAAGG		[2633-2651]
					22	AGGAUGGAGGCAAAAUAAA	UUUAUUUUGCCUCCAUCCU		[2088-2106]
23	ACGUGAAUUUGCUGGUGAA	UUCACCAGCAAAUUCACGU		[2718-2736]
					24	GCUUAUUUAUGUAUCAAUA	UAUUGAUACAUAAAUAAGC		[2279-2297]
25	CCCAGAAGCAGGUGAAGAA	UUCUUCACCUGCUUCUGGG		[838-856]
					26	GGAGAAUGACAGUUUGUCA	UGACAAACUGUCAUUCUCC		[1987-2005]
27	CGUCCGUAGUCUCCUUCUA	UAGAAGGAGACUACGGACG		[769-787]
					28	CAUGUGCAAUAAAUACCAA	UUGGUAUUUAUUGCACAUG		[2830-2848]
29	UGGGCAGAUCUUAAAUAAA	UUUAUUUAAGAUCUGCCCA		[2542-2560]
					30	UGCAAUAAAUACCAAUGAA	UUCAUUGGUAUUUAUUGCA		[2834-2852]
31	CAUCCGAGGCAAAGAGAAA	UUUCUCUUUGCCUCGGAUG		[1633-1651]
					32	UGCACAAAAAGAAAUUAAA	UUUAAUUUCUUUUUGUGCA		[2501-2519]
33	CUGCUGUUAUGAAAGCAAA	UUUGCUUUCAUAACAGCAG		[2064-2082]

34	GAUUUCUGCUGUUAUGAAA	UUUCAUAACAGCAGAAAUC		[2059-2077]
					35	GCACAAAAAGAAAUUAAAU	AUUUAAUUUCUUUUUGUGC		[2502-2520]
36	UGAAGACAGGACAUUAAAA	UUUUAAUGUCCUGUCUUCA		[2353-2371]
					37	GAGAAUGACAGUUUGUCAA	UUGACAAACUGUCAUUCUC		[1988-2006]
38	CGUGAAUUUGCUGGUGAAA	UUUCACCAGCAAAUUCACG		[2719-2737]
					39	GCUAAUGAUUCAUUGGGAA	UUCCCAAUGAAUCAUUAGC		[2598-2616]
40	GAUAGCAGGUGAACUCGAA	UUCGAGUUCACCUGCUAUC		[1593-1611]
					41	CACAGUGUUAGGAAUUACA	UGUAAUUCCUAACACUGUG		[2461-2479]
42	ACGGACCGUUGCACAAAAA	UUUUUGUGCAACGGUCCGU		[1656-1674]
					43	GGAAUUGGUCCAUGUGCAA	UUGCACAUGGACCAAUUCC		[2820-2838]
44	CCAGAGAAAUUUCAUUUUA	UAAAAUGAAAUUUCUCUGG		[2027-2045]
					45	ACAGUGUUAGGAAUUACAA	UUGUAAUUCCUAACACUGU		[2462-2480]
46	GACCGUUGCACAAAAAGGA	UCCUUUUUGUGCAACGGUC		[1659-1677]
					47	GAAAGACUUGUUUAUAUUA	UAAUAUAAACAAGUCUUUC		[2256-2274]
48	CCCACCAGGUGGUUUUUGA	UCAAAAACCACCUGGUGGG		[1836-1854]
					49	GAUAGAAAGACUUGUUUAU	AUAAACAAGUCUUUCUAUC		[2252-2270]
50	ACCAAUGAAGCACAAUCAA	UUGAUUGUGCUUCAUUGGU		[2844-2862]
					51	AAAGGAUGGAGGCAAAAUA	UAUUUUGCCUCCAUCCUUU		[2086-2104]
52	CAGCUUAUUUAUGUAUCAA	UUGAUACAUAAAUAAGCUG		[2277-2295]
					53	GUGGAAGAUGGGUGGGUUA	UAACCCACCCAUCUUCCAC		[1875-1893]
54	CCUCGGAAUCCAAGGUGUA	UACACCUUGGAUUCCGAGG		[1501-1519]
					55	GAAGGGAGAAGCAUUAGGA	UCCUAAUGCUUCUCCCUUC		[1897-1915]
56	GGUUUUUGACACUCUCUGA	UCAGAGAGUGUCAAAAACC		[1846-1864]
					57	CCGUUGCACAAAAAGGAAA	UUUCCUUUUUGUGCAACGG		[1661-1679]
58	UCAGGCUGAGGGAUUUCUA	UAGAAAUCCCUCAGCCUGA		[2208-2226]
					59	AGUGUUAGGAAUUACAAAA	UUUUGUAAUUCCUAACACU		[2464-2482]
60	CGUGUGAUGCAUCUUUAGA	UCUAAAGAUGCAUCACACG		[1808-1826]

61	GUUACUUGCACAAAAAGAA	UUCUUUUUGUGCAAGUAAC		[2495-2513]
					62	CUGAAUCAUCCGAGGCAAA	UUUGCCUCGGAUGAUUCAG		[1627-1645]
63	ACCGUUGCACAAAAAGGAA	UUCCUUUUUGUGCAACGGU		[1660-1678]
					64	UGGAGGCAAAAUAAAAAAA	UUUUUUUAUUUUGCCUCCA		[2092-2110]
65	GGAAAGUUUGGGAAGGGAU	AUCCCUUCCCAAACUUUCC		[1675-1693]
					66	CCAUGUGCAAUAAAUACCA	UGGUAUUUAUUGCACAUGG		[2829-2847]
67	CAGAGAGAGGAGAAUGACA	UGUCAUUCUCCUCUCUCUG		[1979-1997]
					68	CACGUUUCAAGAAAUGUUA	UAACAUUUCUUGAAACGUG		[2114-2132]
69	AGAUAGAAAGACUUGUUUA	UAAACAAGUCUUUCUAUCU		[2251-2269]
					70	AAAUACCAAUGAAGCACAA	UUGUGCUUCAUUGGUAUUU		[2840-2858]
71	GAGGGAUUUCUACCUCACA	UGUGAGGUAGAAAUCCCUC		[2215-2233]
					72	AUGGAGGCAAAAUAAAAAA	UUUUUUAUUUUGCCUCCAU		[2091-2109]
73	ACUGUAUCCAUAUUAUAAA	UUUAUAAUAUGGAUACAGU		[2652-2670]
					74	UUGGGAAAAUACCUUUUUA	UAAAAAGGUAUUUUCCCAA		[2610-2628]
75	CCUUUUGCUUUCCAGAGAA	UUCUCUGGAAAGCAAAAGG		[2016-2034]
					76	GUAUCAAUAUUAGUUGGAA	UUCCAACUAAUAUUGAUAC		[2289-2307]
77	CUGUAUCCAUAUUAUAAAU	AUUUAUAAUAUGGAUACAG		[2653-2671]
					78	GGCUGGGCAGAUCUUAAAU	AUUUAAGAUCUGCCCAGCC		[2539-2557]
79	CAGGCUGAGGGAUUUCUAC	GUAGAAAUCCCUCAGCCUG		[2209-2227]
					80	CAAGAAAUGUUAAGCUCUU	AAGAGCUUAACAUUUCUUG		[2121-2139]
81	UGCGUGUGAUGCAUCUUUA	UAAAGAUGCAUCACACGCA		[1806-1824]
					82	GUGUGAUGCAUCUUUAGAU	AUCUAAAGAUGCAUCACAC		[1809-1827]
83	UUGAAGACAGGACAUUAAA	UUUAAUGUCCUGUCUUCAA		[2352-2370]
					84	UUAUGAAAGCAAAGAGAAA	UUUCUCUUUGCUUUCAUAA		[2070-2088]
85	CUAGUAUGUUAUUGAGCUA	UAGCUCAAUAACAUACUAG		[2583-2601]
					86	UAGAAAGACUUGUUUAUAU	AUAUAAACAAGUCUUUCUA		[2254-2272]
87	ACAGCUUAUUUAUGUAUCA	UGAUACAUAAAUAAGCUGU		[2276-2294]

88	UGAUUUCUGCUGUUAUGAA	UUCAUAACAGCAGAAAUCA		[2058-2076]
					89	GUGCAAUAAAUACCAAUGA	UCAUUGGUAUUUAUUGCAC		[2833-2851]
90	GCAGAUAGAAAGACUUGUU	AACAAGUCUUUCUAUCUGC		[2249-2267]
					91	CAAAAAGGAAAGUUUGGGA	UCCCAAACUUUCCUUUUUG		[1669-1687]
92	AGAAGCAGGUGAAGAAGAU	AUCUUCUUCACCUGCUUCU		[841-859]
					93	GUAACUGUAUCCAUAUUAU	AUAAUAUGGAUACAGUUAC		[2649-2667]
94	AACUGUAUCCAUAUUAUAA	UUAUAAUAUGGAUACAGUU		[2651-2669]
					95	GAAUCAUCCGAGGCAAAGA	UCUUUGCCUCGGAUGAUUC		[1629-1647]
96	GCGUGUGAUGCAUCUUUAG	CUAAAGAUGCAUCACACGC		[1807-1825]
					97	UCAUGGUACUGUAACUGUA	UACAGUUACAGUACCAUGA		[2639-2657]
98	GUUUUACCAAGUAUUUAUA	UAUAAAUACUUGGUAAAAC		[2775-2793]
					99	GGUGAAAGUUAGCACUUGU	ACAAGUGCUAACUUUCACC		[2731-2749]
100	AUUGAAGACAGGACAUUAA	UUAAUGUCCUGUCUUCAAU		[2351-2369]
					101	GACAGGACAUUAAAAGAGA	UCUCUUUUAAUGUCCUGUC		[2357-2375]
102	UGGGAAAAUACCUUUUUAU	AUAAAAAGGUAUUUUCCCA		[2611-2629]
					103	AGCUAAUGAUUCAUUGGGA	UCCCAAUGAAUCAUUAGCU		[2597-2615]
104	UGCACAGCAGAUAGAAAGA	UCUUUCUAUCUGCUGUGCA		[2243-2261]
					105	AGACGCUGGGCAUCAUCAU	AUGAUGAUGCCCAGCGUCU		[1057-1075]
106	AGAAAGACUUGUUUAUAUU	AAUAUAAACAAGUCUUUCU		[2255-2273]
					107	ACGUUUCAAGAAAUGUUAA	UUAACAUUUCUUGAAACGU		[2115-2133]
108	UGGUCCAUGUGCAAUAAAU	AUUUAUUGCACAUGGACCA		[2825-2843]
					109	AGAGAGCGAGAGAGAGAAA	UUUCUCUCUCUCGCUCUCU		[2371-2389]
110	CUACUUCUGUUGUCUAGUA	UACUAGACAACAGAAGUAG		[2570-2588]
					111	GGACAUUAAAAGAGAGCGA	UCGCUCUCUUUUAAUGUCC		[2361-2379]
112	GAAGAUGUUACUUGCACAA	UUGUGCAAGUAACAUCUUC		[2489-2507]
					113	GCUGGGCAGAUCUUAAAUA	UAUUUAAGAUCUGCCCAGC		[2540-2558]
114	CAUGGUACUGUAACUGUAU	AUACAGUUACAGUACCAUG		[2640-2658]

115	CCAUUUUUGCACAGUGUUA	UAACACUGUGCAAAAAUGG		[2452-2470]
					116	CUUUAUCAUGGUACUGUAA	UUACAGUACCAUGAUAAAG		[2634-2652]
117	GUGUUUUACCAAGUAUUUA	UAAAUACUUGGUAAAACAC		[2773-2791]
					118	CGAUAGCAGGUGAACUCGA	UCGAGUUCACCUGCUAUCG		[1592-1610]
119	GCAGAUCUUAAAUAAAAUU	AAUUUUAUUUAAGAUCUGC		[2545-2563]
					120	GCGAGAGAGAGAAACAGUU	AACUGUUUCUCUCUCUCGC		[2376-2394]
121	UGUGACUCUGUCAAUUGAA	UUCAAUUGACAGAGUCACA		[2338-2356]
					122	ACCUUUUUAUACUCCUUUA	UAAAGGAGUAUAAAAAGGU		[2620-2638]
123	UCAUCCGAGGCAAAGAGAA	UUCUCUUUGCCUCGGAUGA		[1632-1650]
					124	AGAAAGGAUGGAGGCAAAA	UUUUGCCUCCAUCCUUUCU		[2084-2102]
125	GAGAGAGGAGAAUGACAGU	ACUGUCAUUCUCCUCUCUC		[1981-1999]
					126	UACUGUAACUGUAUCCAUA	UAUGGAUACAGUUACAGUA		[2645-2663]
127	AAAAAAAAAUCACGUUUCA	UGAAACGUGAUUUUUUUUU		[2104-2122]
					128	CGCCUCUUCGUCUUCUUCA	UGAAGAAGACGAAGAGGCG	大鼠，Ms	[1155-1173]
129	GCACAAAAAGGAAAGUUUG	CAAACUUUCCUUUUUGUGC		[1666-1684]
					130	AGUUCAGAUUACUGCACAU	AUGUGCAGUAAUCUGAACU		[2391-2409]
131	CGCUCACCAACCUCUUCAU	AUGAAGAGGUUGGUGAGCG	大鼠，Ms	[358-376]
					132	CCCACAAUCCUCGUCUGAA	UUCAGACGAGGAUUGUGGG		[1613-1631]
133	UUACUUGCACAAAAAGAAA	UUUCUUUUUGUGCAAGUAA		[2496-2514]
					134	CGUUGCACAAAAAGGAAAG	CUUUCCUUUUUGUGCAACG		[1662-1680]
135	AAGACAGGACAUUAAAAGA	UCUUUUAAUGUCCUGUCUU		[2355-2373]
					136	AGGAAAGUUUGGGAAGGGA	UCCCUUCCCAAACUUUCCU		[1674-1692]
137	GUUAUGAAAGCAAAGAGAA	UUCUCUUUGCUUUCAUAAC		[2069-2087]
					138	CAGAUAGAAAGACUUGUUU	AAACAAGUCUUUCUAUCUG		[2250-2268]
139	UAACUGUAUCCAUAUUAUA	UAUAAUAUGGAUACAGUUA		[2650-2668]
					140	AGAGCGAGAGAGAGAAACA	UGUUUCUCUCUCUCGCUCU		[2373-2391]
141	GAAAAUACCUUUUUAUACU	AGUAUAAAAAGGUAUUUUC		[2614-2632]

142	CAUUUGCACAGCAGAUAGA	UCUAUCUGCUGUGCAAAUG		[2239-2257]
					143	GAUGCAUCUUUAGAUUUUU	AAAAAUCUAAAGAUGCAUC		[1813-1831]
144	CCAGGUGGUUUUUGACACU	AGUGUCAAAAACCACCUGG		[1840-1858]
					145	CAGUUUGUCAAGACAUAUU	AAUAUGUCUUGACAAACUG		[1996-2014]
146	GACUUGUUUAUAUUAAACA	UGUUUAAUAUAAACAAGUC		[2260-2278]
					147	UAAACAGCUUAUUUAUGUA	UACAUAAAUAAGCUGUUUA		[2273-2291]
148	GAGAGAGAGAAACAGUUCA	UGAACUGUUUCUCUCUCUC		[2378-2396]
					149	CCUUUUUAUACUCCUUUAU	AUAAAGGAGUAUAAAAAGG		[2621-2639]
150	AUGUGACUCUGUCAAUUGA	UCAAUUGACAGAGUCACAU		[2337-2355]
					151	GUGUUAGGAAUUACAAAAU	AUUUUGUAAUUCCUAACAC		[2465-2483]
152	AGAAGAUGUUACUUGCACA	UGUGCAAGUAACAUCUUCU		[2488-2506]
					153	CAAUCCUCGUCUGAAUCAU	AUGAUUCAGACGAGGAUUG		[1617-1635]
154	CAGAAGCAGGUGAAGAAGA	UCUUCUUCACCUGCUUCUG		[840-858]
					155	UCACCAACCUCUUCAUCAU	AUGAUGAAGAGGUUGGUGA	大鼠，Ms	[361-379]
156	CGGACCGUUGCACAAAAAG	CUUUUUGUGCAACGGUCCG		[1657-1675]
					157	AGAUUACUGCACAUGUGGA	UCCACAUGUGCAGUAAUCU		[2396-2414]
158	UGUUUUACCAAGUAUUUAU	AUAAAUACUUGGUAAAACA		[2774-2792]
					159	CUUUUGCUUUCCAGAGAAA	UUUCUCUGGAAAGCAAAAG		[2017-2035]
160	UUUGCACAGCAGAUAGAAA	UUUCUAUCUGCUGUGCAAA		[2241-2259]
					161	GAGAGAGAAACAGUUCAGA	UCUGAACUGUUUCUCUCUC		[2380-2398]
162	GAUUAAAAUCGAUCAUCGU	ACGAUGAUCGAUUUUAAUC		[1919-1937]
					163	GAAUGACAGUUUGUCAAGA	UCUUGACAAACUGUCAUUC		[1990-2008]
164	UGUUAAGCUCUUCUUGGAA	UUCCAAGAAGAGCUUAACA		[2128-2146]
					165	GAUUACUGCACAUGUGGAU	AUCCACAUGUGCAGUAAUC		[2397-2415]
166	UGACAUGUGACUCUGUCAA	UUGACAGAGUCACAUGUCA		[2333-2351]
					167	AGAGAAACAGUUCAGAUUA	UAAUCUGAACUGUUUCUCU		[2383-2401]
168	AGCAGGUGAAGAAGAUCGA	UCGAUCUUCUUCACCUGCU		[844-862]

169	CCACCAGGUGGUUUUUGAC	GUCAAAAACCACCUGGUGG		[1837-1855]
					170	AAUAAAUACCAAUGAAGCA	UGCUUCAUUGGUAUUUAUU		[2837-2855]
171	UCUGAAUCAUCCGAGGCAA	UUGCCUCGGAUGAUUCAGA		[1626-1644]
					172	GUGACAUGUGACUCUGUCA	UGACAGAGUCACAUGUCAC		[2332-2350]
173	AAAAAAUCACGUUUCAAGA	UCUUGAAACGUGAUUUUUU		[2107-2125]
					174	AUAGAAAGACUUGUUUAUA	UAUAAACAAGUCUUUCUAU		[2253-2271]
175	AUGUUAAGCUCUUCUUGGA	UCCAAGAAGAGCUUAACAU		[2127-2145]
					176	UGCACAGUGUUAGGAAUUA	UAAUUCCUAACACUGUGCA		[2459-2477]
177	AGGAAUUGGUCCAUGUGCA	UGCACAUGGACCAAUUCCU		[2819-2837]
					178	UACCAAUGAAGCACAAUCA	UGAUUGUGCUUCAUUGGUA		[2843-2861]
179	GGUGGUUUUUGACACUCUC	GAGAGUGUCAAAAACCACC		[1843-1861]
					180	AGGAAUUACAAAAUCCACA	UGUGGAUUUUGUAAUUCCU		[2470-2488]
181	AGCUUAUUUAUGUAUCAAU	AUUGAUACAUAAAUAAGCU		[2278-2296]
					182	AGUAUGUUAUUGAGCUAAU	AUUAGCUCAAUAACAUACU		[2585-2603]
183	GACAUGUGACUCUGUCAAU	AUUGACAGAGUCACAUGUC		[2334-2352]
					184	UCUGUUGUCUAGUAUGUUA	UAACAUACUAGACAACAGA		[2575-2593]
185	CAGUUCAGAUUACUGCACA	UGUGCAGUAAUCUGAACUG		[2390-2408]
					186	AAAUCACGUUUCAAGAAAU	AUUUCUUGAAACGUGAUUU		[2110-2128]
187	CUAAUGAUUCAUUGGGAAA	UUUCCCAAUGAAUCAUUAG		[2599-2617]
					188	AAUGAUUCAUUGGGAAAAU	AUUUUCCCAAUGAAUCAUU		[2601-2619]
189	UGUUAUGAAAGCAAAGAGA	UCUCUUUGCUUUCAUAACA		[2068-2086]
					190	AAAAAAAAUCACGUUUCAA	UUGAAACGUGAUUUUUUUU		[2105-2123]
191	GAGAGAAACAGUUCAGAUU	AAUCUGAACUGUUUCUCUC		[2382-2400]
					192	GUGAACUCGAAGCCCACAA	UUGUGGGCUUCGAGUUCAC		[1601-1619]
193	CUGUAACUGUAUCCAUAUU	AAUAUGGAUACAGUUACAG		[2647-2665]
					194	UGAAUUUGCUGGUGAAAGU	ACUUUCACCAGCAAAUUCA		[2721-2739]
195	GUGCAUUUGCACAGCAGAU	AUCUGCUGUGCAAAUGCAC		[2236-2254]

196	UGUGAUGCAUCUUUAGAUU	AAUCUAAAGAUGCAUCACA		[1810-1828]
					197	AAUUGAAGACAGGACAUUA	UAAUGUCCUGUCUUCAAUU		[2350-2368]
198	GUGUUUACUUAAGACCGAU	AUCGGUCUUAAGUAAACAC		[1577-1595]
					199	AAGAGAGCGAGAGAGAGAA	UUCUCUCUCUCGCUCUCUU		[2370-2388]
200	CUCUCUCUGUGACAUGUGA	UCACAUGUCACAGAGAGAG		[2324-2342]
					201	UGGUCAGGCUGAGGGAUUU	AAAUCCCUCAGCCUGACCA		[2205-2223]
202	AAAAAGGAAAGUUUGGGAA	UUCCCAAACUUUCCUUUUU		[1670-1688]
					203	GCAAUGUGCUGGUGAUCGU	ACGAUCACCAGCACAUUGC		[310-328]
204	AUUGGUCCAUGUGCAAUAA	UUAUUGCACAUGGACCAAU		[2823-2841]
					205	GAGGAGAAUGACAGUUUGU	ACAAACUGUCAUUCUCCUC		[1985-2003]
206	CACCAGGUGGUUUUUGACA	UGUCAAAAACCACCUGGUG		[1838-1856]
					207	UGCACAAAAAGGAAAGUUU	AAACUUUCCUUUUUGUGCA		[1665-1683]
208	CUUUCCAGAGAAAUUUCAU	AUGAAAUUUCUCUGGAAAG		[2023-2041]
					209	GCAUCAUCAUGGGCGUCUU	AAGACGCCCAUGAUGAUGC		[1066-1084]
210	UUAGGAAUUACAAAAUCCA	UGGAUUUUGUAAUUCCUAA		[2468-2486]
					211	AAGACCGAUAGCAGGUGAA	UUCACCUGCUAUCGGUCUU		[1587-1605]
212	AUGUUAUUGAGCUAAUGAU	AUCAUUAGCUCAAUAACAU		[2588-2606]
					213	UGUUGUCUAGUAUGUUAUU	AAUAACAUACUAGACAACA		[2577-2595]
214	GGAAAAUACCUUUUUAUAC	GUAUAAAAAGGUAUUUUCC		[2613-2631]
					215	AACAGUUCAGAUUACUGCA	UGCAGUAAUCUGAACUGUU		[2388-2406]
216	GGAUUAAAAUCGAUCAUCG	CGAUGAUCGAUUUUAAUCC		[1918-1936]
					217	AAGGGAGAAGCAUUAGGAG	CUCCUAAUGCUUCUCCCUU		[1898-1916]
218	AUCCGAGGCAAAGAGAAAA	UUUUCUCUUUGCCUCGGAU		[1634-1652]
					219	GAAAGGAUGGAGGCAAAAU	AUUUUGCCUCCAUCCUUUC		[2085-2103]
220	AGAGAGAAACAGUUCAGAU	AUCUGAACUGUUUCUCUCU		[2381-2399]
					221	GCAAUAAAUACCAAUGAAG	CUUCAUUGGUAUUUAUUGC		[2835-2853]
222	GAAAGCAAAGAGAAAGGAU	AUCCUUUCUCUUUGCUUUC		[2074-2092]

223	ACAUUAAAAGAGAGCGAGA	UCUCGCUCUCUUUUAAUGU		[2363-2381]
					224	UUGCACAAAAAGAAAUUAA	UUAAUUUCUUUUUGUGCAA		[2500-2518]
225	CACAGCAGAUAGAAAGACU	AGUCUUUCUAUCUGCUGUG		[2245-2263]
					226	CUGAGGGAUUUCUACCUCA	UGAGGUAGAAAUCCCUCAG		[2213-2231]
227	CCUCGUCUGAAUCAUCCGA	UCGGAUGAUUCAGACGAGG		[1621-1639]
					228	GUGCCCACGUGAAUUUGCU	AGCAAAUUCACGUGGGCAC		[2712-2730]
229	AGAGGAGAAUGACAGUUUG	CAAACUGUCAUUCUCCUCU		[1984-2002]
					230	AGAGAAAGGAUGGAGGCAA	UUGCCUCCAUCCUUUCUCU		[2082-2100]
231	AAAAAUCACGUUUCAAGAA	UUCUUGAAACGUGAUUUUU		[2108-2126]
					232	CUGUUGUCUAGUAUGUUAU	AUAACAUACUAGACAACAG		[2576-2594]
233	UGUGGUCCGGCCUUCUUUU	AAAAGAAGGCCGGACCACA		[1782-1800]
					234	AAUAUUUUUUAAAGGGAGA	UCUCCCUUUAAAAAAUAUU		[2518-2536]
235	AGAGCCUCUCUCUGUGACA	UGUCACAGAGAGAGGCUCU		[2319-2337]
					236	GCUUGCUGAUGUUCCUUGU	ACAAGGAACAUCAGCAAGC		[1703-1721]
237	ACUGUAACUGUAUCCAUAU	AUAUGGAUACAGUUACAGU		[2646-2664]
					238	GAGUACGGCUCCUUCUUCU	AGAAGAAGGAGCCGUACUC	大鼠，Ms	[459-477]
239	UUACAAAAUCCACAGAAGA	UCUUCUGUGGAUUUUGUAA		[2475-2493]
					240	ACAGCAGAUAGAAAGACUU	AAGUCUUUCUAUCUGCUGU		[2246-2264]
241	UCAAGACGCUGGGCAUCAU	AUGAUGCCCAGCGUCUUGA		[1054-1072]
					242	GCUUUCCAGAGAAAUUUCA	UGAAAUUUCUCUGGAAAGC		[2022-2040]
243	UGUGCAUUUGCACAGCAGA	UCUGCUGUGCAAAUGCACA		[2235-2253]
					244	UGUUAUUGAGCUAAUGAUU	AAUCAUUAGCUCAAUAACA		[2589-2607]
245	UGUUACUUGCACAAAAAGA	UCUUUUUGUGCAAGUAACA		[2494-2512]
					246	GCUGUUAUGAAAGCAAAGA	UCUUUGCUUUCAUAACAGC		[2066-2084]
247	UUAUUGAGCUAAUGAUUCA	UGAAUCAUUAGCUCAAUAA		[2591-2609]
					248	UAAUGAUUCAUUGGGAAAA	UUUUCCCAAUGAAUCAUUA		[2600-2618]
249	ACUCCUUUAUCAUGGUACU	AGUACCAUGAUAAAGGAGU		[2630-2648]

250	ACUCUACUUCUGUUGUCUA	UAGACAACAGAAGUAGAGU		[2567-2585]
					251	AGUGGAAGAUGGGUGGGUU	AACCCACCCAUCUUCCACU		[1874-1892]
252	AGACAUAUUUCCUUUUGCU	AGCAAAAGGAAAUAUGUCU		[2006-2024]
					253	AUAUUAGUUGGAAGGACCA	UGGUCCUUCCAACUAAUAU		[2295-2313]
254	GAGCCUCUCUCUGUGACAU	AUGUCACAGAGAGAGGCUC		[2320-2338]
					255	UGAACUCGAAGCCCACAAU	AUUGUGGGCUUCGAGUUCA		[1602-1620]
256	GAGAAACAGUUCAGAUUAC	GUAAUCUGAACUGUUUCUC		[2384-2402]
					257	AUGAUUCAUUGGGAAAAUA	UAUUUUCCCAAUGAAUCAU		[2602-2620]
258	CUCACACUGUGCAUUUGCA	UGCAAAUGCACAGUGUGAG		[2228-2246]
					259	UAAUGAUUUCUGCUGUUAU	AUAACAGCAGAAAUCAUUA		[2055-2073]
260	GCACAGUGUUAGGAAUUAC	GUAAUUCCUAACACUGUGC		[2460-2478]
					261	UGUUUAUAUUAAACAGCUU	AAGCUGUUUAAUAUAAACA		[2264-2282]
262	GUUUAUAUUAAACAGCUUA	UAAGCUGUUUAAUAUAAAC		[2265-2283]
					263	CCACCUUGCUUUCCUUGUG	CACAAGGAAAGCAAGGUGG		[2153-2171]
264	AGACUUGUUUAUAUUAAAC	GUUUAAUAUAAACAAGUCU		[2259-2277]
					265	CACAAAAAGGAAAGUUUGG	CCAAACUUUCCUUUUUGUG		[1667-1685]
266	UUUUUAUACUCCUUUAUCA	UGAUAAAGGAGUAUAAAAA		[2623-2641]
					267	UGUCUAGUAUGUUAUUGAG	CUCAAUAACAUACUAGACA		[2580-2598]
268	CAAUAUUAGUUGGAAGGAC	GUCCUUCCAACUAAUAUUG		[2293-2311]
					269	GAUUCAUUGGGAAAAUACC	GGUAUUUUCCCAAUGAAUC		[2604-2622]
270	AAUUGGUCCAUGUGCAAUA	UAUUGCACAUGGACCAAUU		[2822-2840]
					271	CAGGUGAAGAAGAUCGACA	UGUCGAUCUUCUUCACCUG	大鼠	[846-864]
272	GUACUGUAACUGUAUCCAU	AUGGAUACAGUUACAGUAC		[2644-2662]
					273	GCUGGUGAAAGUUAGCACU	AGUGCUAACUUUCACCAGC		[2728-2746]
274	ACAGUUUGUCAAGACAUAU	AUAUGUCUUGACAAACUGU		[1995-2013]
					275	UCUGCUGUUAUGAAAGCAA	UUGCUUUCAUAACAGCAGA		[2063-2081]
276	CUUGCACAAAAAGAAAUUA	UAAUUUCUUUUUGUGCAAG		[2499-2517]

277	GAAAGUUUGGGAAGGGAUG	CAUCCCUUCCCAAACUUUC		[1676-1694]
					278	AUUUGCACAGCAGAUAGAA	UUCUAUCUGCUGUGCAAAU		[2240-2258]
279	CAAGUAUUUAUACUCUGGU	ACCAGAGUAUAAAUACUUG		[2782-2800]
					280	ACCGCCUCUUCGUCUUCUU	AAGAAGACGAAGAGGCGGU		[1153-1171]
281	AAUGAUUUCUGCUGUUAUG	CAUAACAGCAGAAAUCAUU		[2056-2074]
					282	GGCUGAGGGAUUUCUACCU	AGGUAGAAAUCCCUCAGCC		[2211-2229]
283	GGACCGUUGCACAAAAAGG	CCUUUUUGUGCAACGGUCC		[1658-1676]
					284	AAAAUCACGUUUCAAGAAA	UUUCUUGAAACGUGAUUUU		[2109-2127]
285	GUCAAUUGAAGACAGGACA	UGUCCUGUCUUCAAUUGAC		[2347-2365]
					286	GGCAAAAUAAAAAAAAAUC	GAUUUUUUUUUAUUUUGCC		[2096-2114]
287	AUGUGCAAUAAAUACCAAU	AUUGGUAUUUAUUGCACAU		[2831-2849]
					288	CUGUCAAUUGAAGACAGGA	UCCUGUCUUCAAUUGACAG		[2345-2363]
289	UGUUUACUUAAGACCGAUA	UAUCGGUCUUAAGUAAACA		[1578-1596]
					290	GAAAUGUUAAGCUCUUCUU	AAGAAGAGCUUAACAUUUC		[2124-2142]
291	UUUUGCACAGUGUUAGGAA	UUCCUAACACUGUGCAAAA		[2456-2474]
					292	AAGACGCUGGGCAUCAUCA	UGAUGAUGCCCAGCGUCUU		[1056-1074]
293	UUUGCACAGUGUUAGGAAU	AUUCCUAACACUGUGCAAA		[2457-2475]
					294	UGCUGUUAUGAAAGCAAAG	CUUUGCUUUCAUAACAGCA		[2065-2083]
295	GGUGCAACUAACUACUGUG	CACAGUAGUUAGUUGCACC		[2798-2816]
					296	CAUUGGGAAAAUACCUUUU	AAAAGGUAUUUUCCCAAUG		[2608-2626]
297	UCAGAUUACUGCACAUGUG	CACAUGUGCAGUAAUCUGA		[2394-2412]
					298	GGGAUUUCUACCUCACACU	AGUGUGAGGUAGAAAUCCC		[2217-2235]
299	UUGUCUAGUAUGUUAUUGA	UCAAUAACAUACUAGACAA		[2579-2597]
					300	AAAGAGAGCGAGAGAGAGA	UCUCUCUCUCGCUCUCUUU		[2369-2387]
301	GUGACUCUGUCAAUUGAAG	CUUCAAUUGACAGAGUCAC		[2339-2357]
					302	AGGUGGUUUUUGACACUCU	AGAGUGUCAAAAACCACCU		[1842-1860]
303	AGGUGAAGAAGAUCGACAG	CUGUCGAUCUUCUUCACCU	大鼠	[847-865]

304	UUAUCAUGGUACUGUAACU	AGUUACAGUACCAUGAUAA		[2636-2654]
					305	UAUACUCUGGUGCAACUAA	UUAGUUGCACCAGAGUAUA		[2790-2808]
306	AGUUUGUCAAGACAUAUUU	AAAUAUGUCUUGACAAACU		[1997-2015]
					307	UUGGUCCAUGUGCAAUAAA	UUUAUUGCACAUGGACCAA		[2824-2842]
308	GAGCGAGAGAGAGAAACAG	CUGUUUCUCUCUCUCGCUC		[2374-2392]
					309	CGUUUCAAGAAAUGUUAAG	CUUAACAUUUCUUGAAACG		[2116-2134]
310	CACGUGAAUUUGCUGGUGA	UCACCAGCAAAUUCACGUG		[2717-2735]
					311	ACUCGAAGCCCACAAUCCU	AGGAUUGUGGGCUUCGAGU		[1605-1623]
312	UGAUGCAUCUUUAGAUUUU	AAAAUCUAAAGAUGCAUCA		[1812-1830]
					313	GUGAGGAAUUGGUCCAUGU	ACAUGGACCAAUUCCUCAC		[2816-2834]
314	UACAAAAUCCACAGAAGAU	AUCUUCUGUGGAUUUUGUA		[2476-2494]
					315	UGACUCUGUCAAUUGAAGA	UCUUCAAUUGACAGAGUCA		[2340-2358]
316	CUUCUGUUGUCUAGUAUGU	ACAUACUAGACAACAGAAG		[2573-2591]
					317	CCGUAGUCUCCUUCUACGU	ACGUAGAAGGAGACUACGG		[772-790]
318	AGACGCUCACCAACCUCUU	AAGAGGUUGGUGAGCGUCU	大鼠，Ms	[355-373]
					319	GUGUGCGUGUGAUGCAUCU	AGAUGCAUCACACGCACAC		[1803-1821]
320	AUGACAGUUUGUCAAGACA	UGUCUUGACAAACUGUCAU		[1992-2010]
					321	GAAGACAGGACAUUAAAAG	CUUUUAAUGUCCUGUCUUC		[2354-2372]
322	AGCAGAUAGAAAGACUUGU	ACAAGUCUUUCUAUCUGCU		[2248-2266]
					323	GAAUUACAAAAUCCACAGA	UCUGUGGAUUUUGUAAUUC		[2472-2490]
324	CAGCAGAUAGAAAGACUUG	CAAGUCUUUCUAUCUGCUG		[2247-2265]
					325	CCAGAAGCAGGUGAAGAAG	CUUCUUCACCUGCUUCUGG		[839-857]
326	GGGAAGGGAGAAGCAUUAG	CUAAUGCUUCUCCCUUCCC		[1895-1913]
					327	GUCUGAAUCAUCCGAGGCA	UGCCUCGGAUGAUUCAGAC		[1625-1643]
328	UCAUCGUGCUGCUCAUCGU	ACGAUGAGCAGCACGAUGA	大鼠	[286-304]
					329	AGUAAUGAUUUCUGCUGUU	AACAGCAGAAAUCAUUACU		[2053-2071]
330	CAAAAUCCACAGAAGAUGU	ACAUCUUCUGUGGAUUUUG		[2478-2496]

331	AGAAGAUCGACAGCUGCGA	UCGCAGCUGUCGAUCUUCU	大鼠，Ms	[853-871]
					332	AGCGAGAGAGAGAAACAGU	ACUGUUUCUCUCUCUCGCU		[2375-2393]
333	AUGCAUCUUUAGAUUUUUU	AAAAAAUCUAAAGAUGCAU		[1814-1832]
					334	ACUCUGGUGCAACUAACUA	UAGUUAGUUGCACCAGAGU		[2793-2811]
335	GGAAUUACAAAAUCCACAG	CUGUGGAUUUUGUAAUUCC		[2471-2489]
					336	UUUGGGAAGGGAUGGGAGA	UCUCCCAUCCCUUCCCAAA		[1681-1699]
337	UGGUGCAACUAACUACUGU	ACAGUAGUUAGUUGCACCA		[2797-2815]
					338	GGUACUGUAACUGUAUCCA	UGGAUACAGUUACAGUACC		[2643-2661]
339	CUCUACUUCUGUUGUCUAG	CUAGACAACAGAAGUAGAG		[2568-2586]
					340	GCAUUUGCACAGCAGAUAG	CUAUCUGCUGUGCAAAUGC		[2238-2256]
341	CUGUUAUGAAAGCAAAGAG	CUCUUUGCUUUCAUAACAG		[2067-2085]
					342	UCACGUUUCAAGAAAUGUU	AACAUUUCUUGAAACGUGA		[2113-2131]
343	GAGAGGAGAAUGACAGUUU	AAACUGUCAUUCUCCUCUC		[1983-2001]
					344	GUUGCACAAAAAGGAAAGU	ACUUUCCUUUUUGUGCAAC		[1663-1681]
345	GUGCGUGUGAUGCAUCUUU	AAAGAUGCAUCACACGCAC		[1805-1823]
					346	GUAUUUAUACUCUGGUGCA	UGCACCAGAGUAUAAAUAC		[2785-2803]
347	CCAAGUAUUUAUACUCUGG	CCAGAGUAUAAAUACUUGG		[2781-2799]
					348	UUUUAUACUCCUUUAUCAU	AUGAUAAAGGAGUAUAAAA		[2624-2642]
349	AAUUCAAACUCUACUUCUG	CAGAAGUAGAGUUUGAAUU		[2560-2578]
					350	UAUUUAUACUCUGGUGCAA	UUGCACCAGAGUAUAAAUA		[2786-2804]
351	ACUUGUUUAUAUUAAACAG	CUGUUUAAUAUAAACAAGU		[2261-2279]
					352	CAAUAAAUACCAAUGAAGC	GCUUCAUUGGUAUUUAUUG		[2836-2854]
353	CCAAGUGCCCACGUGAAUU	AAUUCACGUGGGCACUUGG		[2708-2726]
					354	ACAUGUGACUCUGUCAAUU	AAUUGACAGAGUCACAUGU		[2335-2353]
355	CCAGAGAGAGGAGAAUGAC	GUCAUUCUCCUCUCUCUGG		[1978-1996]
					356	CUGUGACAUGUGACUCUGU	ACAGAGUCACAUGUCACAG		[2330-2348]
357	UAAAAGAGAGCGAGAGAGA	UCUCUCUCGCUCUCUUUUA		[2367-2385]

358	UCUGGUGCAACUAACUACU	AGUAGUUAGUUGCACCAGA		[2795-2813]
					359	GCCUCUCUCUGUGACAUGU	ACAUGUCACAGAGAGAGGC		[2322-2340]
360	GACCGAUAGCAGGUGAACU	AGUUCACCUGCUAUCGGUC		[1589-1607]
					361	AGCUCUUCUUGGAACAAGC	GCUUGUUCCAAGAAGAGCU		[2133-2151]
362	GAAUUUGCUGGUGAAAGUU	AACUUUCACCAGCAAAUUC		[2722-2740]
					363	GCAGGUGAAGAAGAUCGAC	GUCGAUCUUCUUCACCUGC		[845-863]
364	UGACAGUUUGUCAAGACAU	AUGUCUUGACAAACUGUCA		[1993-2011]
					365	GCAUCUUUAGAUUUUUUUC	GAAAAAAAUCUAAAGAUGC		[1816-1834]
366	ACAGGACAUUAAAAGAGAG	CUCUCUUUUAAUGUCCUGU		[2358-2376]
					367	UAAGCUCUUCUUGGAACAA	UUGUUCCAAGAAGAGCUUA		[2131-2149]
368	GGAAGGGAGAAGCAUUAGG	CCUAAUGCUUCUCCCUUCC		[1896-1914]
					369	UGUCAAGACAUAUUUCCUU	AAGGAAAUAUGUCUUGACA		[2001-2019]
370	AAUUACAAAAUCCACAGAA	UUCUGUGGAUUUUGUAAUU		[2473-2491]
					371	GUAUGUUAUUGAGCUAAUG	CAUUAGCUCAAUAACAUAC		[2586-2604]
372	GUGGUUUUUGACACUCUCU	AGAGAGUGUCAAAAACCAC		[1844-1862]
					373	AGUUUGGGAAGGGAUGGGA	UCCCAUCCCUUCCCAAACU		[1679-1697]
374	CUCUUCGUCUUCUUCAACU	AGUUGAAGAAGACGAAGAG	大鼠，Ms	[1158-1176]
					375	CUGGUGAAAGUUAGCACUU	AAGUGCUAACUUUCACCAG		[2729-2747]
376	AUUCAUUGGGAAAAUACCU	AGGUAUUUUCCCAAUGAAU		[2605-2623]
					377	ACAGAAGAUGUUACUUGCA	UGCAAGUAACAUCUUCUGU		[2486-2504]
378	UAGGAAUUACAAAAUCCAC	GUGGAUUUUGUAAUUCCUA		[2469-2487]
					379	CAAGUGCCCACGUGAAUUU	AAAUUCACGUGGGCACUUG		[2709-2727]
380	GACAUAUUUCCUUUUGCUU	AAGCAAAAGGAAAUAUGUC		[2007-2025]
					381	GUCAAGACAUAUUUCCUUU	AAAGGAAAUAUGUCUUGAC		[2002-2020]
382	CUAAGUAAUGAUUUCUGCU	AGCAGAAAUCAUUACUUAG		[2050-2068]
					383	UCAAUUGAAGACAGGACAU	AUGUCCUGUCUUCAAUUGA		[2348-2366]
384	AUUUGCUGGUGAAAGUUAG	CUAACUUUCACCAGCAAAU		[2724-2742]

385	UACUUCUGUUGUCUAGUAU	AUACUAGACAACAGAAGUA		[2571-2589]
					386	CACACUGUGCAUUUGCACA	UGUGCAAAUGCACAGUGUG		[2230-2248]
387	CGAGGCAAAGAGAAAAGCC	GGCUUUUCUCUUUGCCUCG		[1637-1655]
					388	ACCUCUUCAUCAUGUCCCU	AGGGACAUGAUGAAGAGGU	大鼠，Ms	[367-385]
389	UAUGUUAUUGAGCUAAUGA	UCAUUAGCUCAAUAACAUA		[2587-2605]
					390	UAUUGAGCUAAUGAUUCAU	AUGAAUCAUUAGCUCAAUA		[2592-2610]
391	AUUAAAAGAGAGCGAGAGA	UCUCUCGCUCUCUUUUAAU		[2365-2383]
					392	CAAUUGAAGACAGGACAUU	AAUGUCCUGUCUUCAAUUG		[2349-2367]
393	UGUAACUGUAUCCAUAUUA	UAAUAUGGAUACAGUUACA		[2648-2666]
					394	CGAGAGAGAGAAACAGUUC	GAACUGUUUCUCUCUCUCG		[2377-2395]
395	ACUUGCACAAAAAGAAAUU	AAUUUCUUUUUGUGCAAGU		[2498-2516]
					396	CAGAUUACUGCACAUGUGG	CCACAUGUGCAGUAAUCUG		[2395-2413]
397	AAGUGCUGCGACUUCGUCA	UGACGAAGUCGCAGCACUU		[726-744]
					398	AAGAUGUUACUUGCACAAA	UUUGUGCAAGUAACAUCUU		[2490-2508]
399	UUGUGGUCCGGCCUUCUUU	AAAGAAGGCCGGACCACAA		[1781-1799]
					400	AGGGAUUUCUACCUCACAC	GUGUGAGGUAGAAAUCCCU		[2216-2234]
401	GUCCAUGUGCAAUAAAUAC	GUAUUUAUUGCACAUGGAC		[2827-2845]
					402	UAAAAUUCAAACUCUACUU	AAGUAGAGUUUGAAUUUUA		[2557-2575]
403	AAUUUGCUGGUGAAAGUUA	UAACUUUCACCAGCAAAUU		[2723-2741]
					404	ACAAUCCUCGUCUGAAUCA	UGAUUCAGACGAGGAUUGU		[1616-1634]
405	UCCAAGUGCCCACGUGAAU	AUUCACGUGGGCACUUGGA		[2707-2725]
					406	UACUCUGGUGCAACUAACU	AGUUAGUUGCACCAGAGUA		[2792-2810]
407	UCCUUUUGCUUUCCAGAGA	UCUCUGGAAAGCAAAAGGA		[2015-2033]
					408	CCCACCUUGCUUUCCUUGU	ACAAGGAAAGCAAGGUGGG		[2152-2170]
409	CUCUGUCAAUUGAAGACAG	CUGUCUUCAAUUGACAGAG		[2343-2361]
					410	UAGUAUGUUAUUGAGCUAA	UUAGCUCAAUAACAUACUA		[2584-2602]
411	CAAACUCUACUUCUGUUGU	ACAACAGAAGUAGAGUUUG		[2564-2582]

412	AUUCAAACUCUACUUCUGU	ACAGAAGUAGAGUUUGAAU		[2561-2579]
					413	AAAUAUUUUUUAAAGGGAG	CUCCCUUUAAAAAAUAUUU		[2517-2535]
414	CCUCUUCGUCUUCUUCAAC	GUUGAAGAAGACGAAGAGG	大鼠，Ms	[1157-1175]
					415	GUAAUGAUUUCUGCUGUUA	UAACAGCAGAAAUCAUUAC		[2054-2072]
416	UCAUCAUGGGCGUCUUCAC	GUGAAGACGCCCAUGAUGA		[1069-1087]
					417	AGCAAAGAGAAAGGAUGGA	UCCAUCCUUUCUCUUUGCU		[2077-2095]
418	GAAACAGUUCAGAUUACUG	CAGUAAUCUGAACUGUUUC		[2386-2404]
					419	CUCGGAAUCCAAGGUGUAG	CUACACCUUGGAUUCCGAG		[1502-1520]
420	UAAGACCGAUAGCAGGUGA	UCACCUGCUAUCGGUCUUA		[1586-1604]
					421	UGCAUUUGCACAGCAGAUA	UAUCUGCUGUGCAAAUGCA		[2237-2255]
422	UAUCAAUAUUAGUUGGAAG	CUUCCAACUAAUAUUGAUA		[2290-2308]
					423	UUAAGCUCUUCUUGGAACA	UGUUCCAAGAAGAGCUUAA		[2130-2148]
424	UUGUCAAGACAUAUUUCCU	AGGAAAUAUGUCUUGACAA		[2000-2018]
					425	AGAAACAGUUCAGAUUACU	AGUAAUCUGAACUGUUUCU		[2385-2403]
426	AUCAUCCGAGGCAAAGAGA	UCUCUUUGCCUCGGAUGAU		[1631-1649]
					427	CACAGAAGAUGUUACUUGC	GCAAGUAACAUCUUCUGUG		[2485-2503]
428	AAGAGAAAGGAUGGAGGCA	UGCCUCCAUCCUUUCUCUU		[2081-2099]
					429	AAAUCCACAGAAGAUGUUA	UAACAUCUUCUGUGGAUUU		[2480-2498]
430	UGAAAGCAAAGAGAAAGGA	UCCUUUCUCUUUGCUUUCA		[2073-2091]
					431	GUUUGUCAAGACAUAUUUC	GAAAUAUGUCUUGACAAAC		[1998-2016]
432	GUCCGUAGUCUCCUUCUAC	GUAGAAGGAGACUACGGAC		[770-788]
					433	UAAAUACCAAUGAAGCACA	UGUGCUUCAUUGGUAUUUA		[2839-2857]
434	AAAUUCAAACUCUACUUCU	AGAAGUAGAGUUUGAAUUU		[2559-2577]
					435	UUUCCUUUUGCUUUCCAGA	UCUGGAAAGCAAAAGGAAA		[2013-2031]
436	AAGUAAUGAUUUCUGCUGU	ACAGCAGAAAUCAUUACUU		[2052-2070]
					437	AUGAUUUCUGCUGUUAUGA	UCAUAACAGCAGAAAUCAU		[2057-2075]
438	UGAAGAAGAUCGACAGCUG	CAGCUGUCGAUCUUCUUCA	大鼠	[850-868]

439	UACCAAGUAUUUAUACUCU	AGAGUAUAAAUACUUGGUA		[2779-2797]
					440	GUAAAUUCUACUUCCUCUU	AAGAGGAAGUAGAAUUUAC		[2752-2770]
441	UCAAUAUUAGUUGGAAGGA	UCCUUCCAACUAAUAUUGA		[2292-2310]
					442	CUCUCUGUGACAUGUGACU	AGUCACAUGUCACAGAGAG		[2326-2344]
443	AAGUAUUUAUACUCUGGUG	CACCAGAGUAUAAAUACUU		[2783-2801]
					444	UGUAAAUUCUACUUCCUCU	AGAGGAAGUAGAAUUUACA		[2751-2769]
445	CAUUUUUGCACAGUGUUAG	CUAACACUGUGCAAAAAUG		[2453-2471]
					446	UUUCCAGAGAAAUUUCAUU	AAUGAAAUUUCUCUGGAAA		[2024-2042]
447	AUACCUUUUUAUACUCCUU	AAGGAGUAUAAAAAGGUAU		[2618-2636]
					448	UUCAAACUCUACUUCUGUU	AACAGAAGUAGAGUUUGAA		[2562-2580]
449	GUGUGAGGAAUUGGUCCAU	AUGGACCAAUUCCUCACAC		[2814-2832]
					450	UCCAGAGAAAUUUCAUUUU	AAAAUGAAAUUUCUCUGGA		[2026-2044]
451	UUGUUUAUAUUAAACAGCU	AGCUGUUUAAUAUAAACAA		[2263-2281]
					452	UUUGCUUUCCAGAGAAAUU	AAUUUCUCUGGAAAGCAAA		[2019-2037]
453	UGCAUCUUUAGAUUUUUUU	AAAAAAAUCUAAAGAUGCA		[1815-1833]
					454	UUUUUGACACUCUCUGAGA	UCUCAGAGAGUGUCAAAAA		[1848-1866]
455	CUGUGCAUUUGCACAGCAG	CUGCUGUGCAAAUGCACAG		[2234-2252]
					456	AGAGAGAGAAACAGUUCAG	CUGAACUGUUUCUCUCUCU		[2379-2397]
457	UGAUUCAUUGGGAAAAUAC	GUAUUUUCCCAAUGAAUCA		[2603-2621]
					458	AAACAGCUUAUUUAUGUAU	AUACAUAAAUAAGCUGUUU		[2274-2292]
459	CGUAGUCUCCUUCUACGUG	CACGUAGAAGGAGACUACG		[773-791]
					460	UGUUAGGAAUUACAAAAUC	GAUUUUGUAAUUCCUAACA		[2466-2484]
461	UACUUGCACAAAAAGAAAU	AUUUCUUUUUGUGCAAGUA		[2497-2515]
					462	CUCUGGUGCAACUAACUAC	GUAGUUAGUUGCACCAGAG		[2794-2812]
463	UCGUCUGAAUCAUCCGAGG	CCUCGGAUGAUUCAGACGA		[1623-1641]
					464	AAAAGGAAAGUUUGGGAAG	CUUCCCAAACUUUCCUUUU		[1671-1689]
465	AUUACAAAAUCCACAGAAG	CUUCUGUGGAUUUUGUAAU		[2474-2492]

466	UUGCACAGCAGAUAGAAAG	CUUUCUAUCUGCUGUGCAA		[2242-2260]
					467	GUGAAAGUUAGCACUUGUG	CACAAGUGCUAACUUUCAC		[2732-2750]
468	CUUGCUGAUGUUCCUUGUU	AACAAGGAACAUCAGCAAG		[1704-1722]
					469	UGUGCAAUAAAUACCAAUG	CAUUGGUAUUUAUUGCACA		[2832-2850]
470	AAUAAAAUUCAAACUCUAC	GUAGAGUUUGAAUUUUAUU		[2555-2573]
					471	UGAGGGAUUUCUACCUCAC	GUGAGGUAGAAAUCCCUCA		[2214-2232]
472	AAUCAUCCGAGGCAAAGAG	CUCUUUGCCUCGGAUGAUU		[1630-1648]
					473	CUCUGUGACAUGUGACUCU	AGAGUCACAUGUCACAGAG		[2328-2346]
474	UGUAUCAAUAUUAGUUGGA	UCCAACUAAUAUUGAUACA		[2288-2306]
					475	UCAUUGGGAAAAUACCUUU	AAAGGUAUUUUCCCAAUGA		[2607-2625]
476	AUAAAAUUCAAACUCUACU	AGUAGAGUUUGAAUUUUAU		[2556-2574]
					477	AGAAAUGUUAAGCUCUUCU	AGAAGAGCUUAACAUUUCU		[2123-2141]
478	CUCACCAACCUCUUCAUCA	UGAUGAAGAGGUUGGUGAG	大鼠，Ms	[360-378]
					479	GUGAUGCAUCUUUAGAUUU	AAAUCUAAAGAUGCAUCAC		[1811-1829]
480	CAAGACAUAUUUCCUUUUG	CAAAAGGAAAUAUGUCUUG		[2004-2022]
					481	GAAGCAGGUGAAGAAGAUC	GAUCUUCUUCACCUGCUUC		[842-860]
482	AUUGGGAAAAUACCUUUUU	AAAAAGGUAUUUUCCCAAU		[2609-2627]
					483	AGAGAGAGGAGAAUGACAG	CUGUCAUUCUCCUCUCUCU		[1980-1998]
484	UUCAGAUUACUGCACAUGU	ACAUGUGCAGUAAUCUGAA		[2393-2411]
					485	GUCAGGCUGAGGGAUUUCU	AGAAAUCCCUCAGCCUGAC		[2207-2225]
486	CACAAUCCUCGUCUGAAUC	GAUUCAGACGAGGAUUGUG		[1615-1633]
					487	UACUUAAGACCGAUAGCAG	CUGCUAUCGGUCUUAAGUA		[1582-1600]
488	UCAAGACAUAUUUCCUUUU	AAAAGGAAAUAUGUCUUGA		[2003-2021]
					489	GGUGAAGAAGAUCGACAGC	GCUGUCGAUCUUCUUCACC	大鼠	[848-866]
490	AAAUGUUAAGCUCUUCUUG	CAAGAAGAGCUUAACAUUU		[2125-2143]
					491	GGAUUUCUACCUCACACUG	CAGUGUGAGGUAGAAAUCC		[2218-2236]
492	UCAAGAAAUGUUAAGCUCU	AGAGCUUAACAUUUCUUGA		[2120-2138]

493	CAUUAAAAGAGAGCGAGAG	CUCUCGCUCUCUUUUAAUG		[2364-2382]
					494	UCUUCGUCUUCUUCAACUG	CAGUUGAAGAAGACGAAGA	大鼠，Ms	[1159-1177]
495	UCCGAGGCAAAGAGAAAAG	CUUUUCUCUUUGCCUCGGA		[1635-1653]
					496	GAAUUGGUCCAUGUGCAAU	AUUGCACAUGGACCAAUUC		[2821-2839]
497	UAUACUCCUUUAUCAUGGU	ACCAUGAUAAAGGAGUAUA		[2627-2645]
					498	AAUACCAAUGAAGCACAAU	AUUGUGCUUCAUUGGUAUU		[2841-2859]
499	UGGUGAAAGUUAGCACUUG	CAAGUGCUAACUUUCACCA		[2730-2748]
					500	AUACUCUGGUGCAACUAAC	GUUAGUUGCACCAGAGUAU		[2791-2809]

表B3 AIFM1-凋亡诱导因子，线粒体相关，1

表B4 AKR1B1-醛酮还原酶家族1，成员B1(醛糖还原酶)

No.	正义链siRNA	反义链siRNA	其他Sp	人-24497579：75-1025
					1	GCUUGAUGUUGGAUCUCAA	UUGAGAUCCAACAUCAAGC		[1164-1182]
2	AGGUGGAGAUGAUCUUAAA	UUUAAGAUCAUCUCCACCU		[571-589]
					3	CAAGCACAAUAAAACUACA	UGUAGUUUUAUUGUGCUUG	Chmp	[791-809]
4	UGGAGAUGAUCUUAAACAA	UUGUUUAAGAUCAUCUCCA		[574-592]
					5	GGAGAUGAUCUUAAACAAA	UUUGUUUAAGAUCAUCUCC		[575-593]
6	CAAAGAGAAGCAAAAUCUA	UAGAUUUUGCUUCUCUUUG	Chmp	[1277-1295]
					7	GGUGCACGUACCAUGAGAA	UUCUCAUGGUACGUGCACC	Chmp	[313-331]
8	UGACCAAAGAGAAGCAAAA	UUUUGCUUCUCUUUGGUCA	Chmp	[1273-1291]
					9	GGAAGAGCUGGUGGAUGAA	UUCAUCCACCAGCUCUUCC	Chmp	[509-527]
10	CCCUGUCAGUAGAGUAGAA	UUCUACUCUACUGACAGGG	Chmp	[1186-1204]
					11	GGAUGAAGGGCUGGUGAAA	UUUCACCAGCCCUUCAUCC	Chmp	[521-539]
12	AGGAGAAGUUAAUCCAGUA	UACUGGAUUAACUUCUCCU	Chmp	[652-670]
					13	CGCAUUGCUGAGAACUUUA	UAAAGUUCUCAGCAAUGCG	Chmp	[879-897]
14	CCAGGAUAUGACCACCUUA	UAAGGUGGUCAUAUCCUGG	Chmp	[923-941]
					15	CCAAGUCUGUGACACCAGA	UCUGGUGUCACAGACUUGG	Chmp	[859-877]
16	AGCUCUUCAUCGUCAGCAA	UUGCUGACGAUGAAGAGCU	Rb，Chmp	[289-307]
					17	GCAUUGCUGAGAACUUUAA	UUAAAGUUCUCAGCAAUGC	Chmp	[880-898]
18	AGUGGGACAGCAACCUGUA	UACAGGUUGCUGUCCCACU		[1121-1139]
					19	GAGUUUUGACUGCUUGGAA	UUCCAAGCAGUCAAAACUC	Chmp	[1324-1342]

20	CCACCUUACUCAGCUACAA	UUGUAGCUGAGUAAGGUGG	Chmp	[934-952]
					21	GCAAAAUCUACCAGGUCAA	UUGACCUGGUAGAUUUUGC	Chmp	[1286-1304]
22	AGACACUCAGCGACCUGAA	UUCAGGUCGCUGAGUGUCU	Chmp	[358-376]
					23	CAGGUGGAGAUGAUCUUAA	UUAAGAUCAUCUCCACCUG		[570-588]
24	CAAGUCUGUGACACCAGAA	UUCUGGUGUCACAGACUUG	Chmp	[860-878]
					25	AUGAGAAGGGCCUGGUGAA	UUCACCAGGCCCUUCUCAU	Chmp	[325-343]
26	GGGAAAGUACAACCUGAAU	AUUCAGGUUGUACUUUCCC	Chmp	[1245-1263]
					27	CCUGAAUACCCUUUUCUGA	UCAGAAAAGGGUAUUCAGG	Chmp	[1257-1275]
28	AGAGGAACUUGGUGGUGAU	AUCACCACCAAGUUCCUCU	Chmp	[838-856]
					29	UGGACUACCUGGACCUCUA	UAGAGGUCCAGGUAGUCCA	大鼠，Rb，Chmp	[379-397]
30	UGUGGUGCACGUACCAUGA	UCAUGGUACGUGCACCACA	Chmp	[310-328]
					31	AGUAUAAGCCUGCAGUUAA	UUAACUGCAGGCUUAUACU	Chmp	[604-622]
32	AGGAAUUUUUCCCAUUGGA	UCCAAUGGGAAAAAUUCCU		[433-451]
					33	UGGUGCACGUACCAUGAGA	UCUCAUGGUACGUGCACCA	Chmp	[312-330]
34	CAGAACGCAUUGCUGAGAA	UUCUCAGCAAUGCGUUCUG	Chmp	[874-892]
					35	CCAACUUCAACCAUCUCCA	UGGAGAUGGUUGAAGUUGG	Chmp	[553-571]
36	UAAGGUCUUUGACUUUGAA	UUCAAAGUCAAAGACCUUA	Chmp	[896-914]
					37	CUCACUCAGGAGAAGUUAA	UUAACUUCUCCUGAGUGAG	Chmp	[645-663]
38	ACUGGAAUCCUUUCAGCAA	UUGCUGAAAGGAUUCCAGU		[1342-1360]
					39	CAAGAGCCCUGUCAGUAGA	UCUACUGACAGGGCUCUUG	Chmp	[1180-1198]
40	UGAGAAGGGCCUGGUGAAA	UUUCACCAGGCCCUUCUCA	Chmp	[326-344]
					41	UGUCUAGCUUGAUGUUGGA	UCCAACAUCAAGCUAGACA		[1158-1176]
42	CUUUAAGCCUGGGAAGGAA	UUCCUUCCCAGGCUUAAAG	Chmp	[419-437]
					43	CUGACCAAAGAGAAGCAAA	UUUGCUUCUCUUUGGUCAG	Chmp	[1272-1290]
44	CAAAAUCUACCAGGUCAAA	UUUGACCUGGUAGAUUUUG	Chmp	[1287-1305]
					45	UGAGCUGUACCUCCCACAA	UUGUGGGAGGUACAGCUCA	Chmp	[979-997]
46	GGAAAGUACAACCUGAAUA	UAUUCAGGUUGUACUUUCC	Chmp	[1246-1264]

47	GUAUAAGCCUGCAGUUAAC	GUUAACUGCAGGCUUAUAC	Chmp	[605-623]
					48	GGAAUUUUUCCCAUUGGAU	AUCCAAUGGGAAAAAUUCC		[434-452]
49	GAAGUAUAAGCCUGCAGUU	AACUGCAGGCUUAUACUUC	Chmp	[602-620]
					50	UGGAAUCCUUUCAGCAAGA	UCUUGCUGAAAGGAUUCCA		[1344-1362]
51	CUGUGACACCAGAACGCAU	AUGCGUUCUGGUGUCACAG	Chmp	[865-883]
					52	UUCCAUGAAGAGUUUUGAA	UUCAAAACUCUUCAUGGAA	Chmp	[1008-1026]
53	UCAUUUUUUUCCUUGCAAA	UUUGCAAGGAAAAAAAUGA	Chmp	[1077-1095]
					54	ACCCUUUUCUGACCAAAGA	UCUUUGGUCAGAAAAGGGU	Chmp	[1264-1282]
55	UGGAGGAUCCCAGGAUCAA	UUGAUCCUGGGAUCCUCCA	大鼠，Ms，Chmp	[760-778]
					56	GACCAAAGAGAAGCAAAAU	AUUUUGCUUCUCUUUGGUC	Chmp	[1274-1292]
57	CCAGGUGGAGAUGAUCUUA	UAAGAUCAUCUCCACCUGG		[569-587]
					58	GCUUGGAACUGGAAUCCUU	AAGGAUUCCAGUUCCAAGC		[1335-1353]
59	GCAUCUCCAACUUCAACCA	UGGUUGAAGUUGGAGAUGC	Chmp	[547-565]
					60	GAAGGGCUGGUGAAAGCUA	UAGCUUUCACCAGCCCUUC	Chmp	[525-543]
61	AAGGGCUGGUGAAAGCUAU	AUAGCUUUCACCAGCCCUU	Chmp	[526-544]
					62	GAGCCCUGUCAGUAGAGUA	UACUCUACUGACAGGGCUC	Chmp	[1183-1201]
63	ACCCAUAUCUCACUCAGGA	UCCUGAGUGAGAUAUGGGU	Chmp	[637-655]
					64	GGUUGAGUUUUGACUGCUU	AAGCAGUCAAAACUCAACC		[1320-1338]
65	AGAACUUUAAGGUCUUUGA	UCAAAGACCUUAAAGUUCU	大鼠，Chmp	[889-907]
					66	CUUUUCUGACCAAAGAGAA	UUCUCUUUGGUCAGAAAAG	Chmp	[1267-1285]
67	UGGAUGAAGGGCUGGUGAA	UUCACCAGCCCUUCAUCCA	Chmp	[520-538]
					68	CUUCCAUGAAGAGUUUUGA	UCAAAACUCUUCAUGGAAG	Chmp	[1007-1025]
69	CAUUGGAUGAGUCGGGCAA	UUGCCCGACUCAUCCAAUG		[445-463]
					70	GUACCUCCCACAAGGAUUA	UAAUCCUUGUGGGAGGUAC	Chmp	[985-1003]
71	CAUUUUUUUCCUUGCAAAU	AUUUGCAAGGAAAAAAAUG	Chmp	[1078-1096]
					72	CAGGAGAAGUUAAUCCAGU	ACUGGAUUAACUUCUCCUG	Chmp	[651-669]
73	GCGUGUCUAGCUUGAUGUU	AACAUCAAGCUAGACACGC		[1155-1173]

74	UGGAAGAGCUGGUGGAUGA	UCAUCCACCAGCUCUUCCA	Chmp	[508-526]
					75	CAUAUCUCACUCAGGAGAA	UUCUCCUGAGUGAGAUAUG	Chmp	[640-658]
76	AGGGCUGGUGAAAGCUAUU	AAUAGCUUUCACCAGCCCU	Chmp	[527-545]
					77	AGAGAAGCAAAAUCUACCA	UGGUAGAUUUUGCUUCUCU	Chmp	[1280-1298]
78	AAGCGUGAGGAGCUCUUCA	UGAAGAGCUCCUCACGCUU	Chmp	[279-297]
					79	AAGCCUGCAGUUAACCAGA	UCUGGUUAACUGCAGGCUU	Chmp	[609-627]
80	CGGGCUAUUUAAAGGUACG	CGUACCUUUAAAUAGCCCG		[2-20]
					81	CAUGGAAGAGCUGGUGGAU	AUCCACCAGCUCUUCCAUG	Chmp	[506-524]
82	CUGAGAACUUUAAGGUCUU	AAGACCUUAAAGUUCUCAG	大鼠，Chmp	[886-904]
					83	GCAAUGUGGUUCCCAGUGA	UCACUGGGAACCACAUUGC	Chmp	[460-478]
84	CUGCAGUUAACCAGAUUGA	UCAAUCUGGUUAACUGCAG	Chmp	[613-631]
					85	AAAUCUACCAGGUCAAAAU	AUUUUGACCUGGUAGAUUU	Chmp	[1289-1307]
86	AAUCUACCAGGUCAAAAUA	UAUUUUGACCUGGUAGAUU	Chmp	[1290-1308]
					87	CAAUGUGGUUCCCAGUGAC	GUCACUGGGAACCACAUUG	Chmp	[461-479]
88	CACCAGAACGCAUUGCUGA	UCAGCAAUGCGUUCUGGUG	Chmp	[871-889]
					89	CUCAGGAGAAGUUAAUCCA	UGGAUUAACUUCUCCUGAG	Chmp	[649-667]
90	GAAGCAAAAUCUACCAGGU	ACCUGGUAGAUUUUGCUUC	Chmp	[1283-1301]
					91	GAGGAGCUCUUCAUCGUCA	UGACGAUGAAGAGCUCCUC	Rb，Chmp	[285-303]
92	CCAUGCAGAGGAACUUGGU	ACCAAGUUCCUCUGCAUGG	Chmp	[832-850]
					93	CCAGUGACACCAACAUUCU	AGAAUGUUGGUGUCACUGG	Chmp	[472-490]
94	GGUGGAGAUGAUCUUAAAC	GUUUAAGAUCAUCUCCACC		[572-590]
					95	GUGACACCAACAUUCUGGA	UCCAGAAUGUUGGUGUCAC	Chmp	[475-493]
96	UUUCCUUGCAAAUGUAGUA	UACUACAUUUGCAAGGAAA	Chmp	[1084-1102]
					97	CCACCCAUAUCUCACUCAG	CUGAGUGAGAUAUGGGUGG	Chmp	[635-653]
98	CUUGAAGUAUAAGCCUGCA	UGCAGGCUUAUACUUCAAG	Chmp	[599-617]
					99	GCCUGCAGUUAACCAGAUU	AAUCUGGUUAACUGCAGGC	Chmp	[611-629]
100	CUCAUUUUUUUCCUUGCAA	UUGCAAGGAAAAAAAUGAG	Chmp	[1076-1094]

101	CCUUUUCUGACCAAAGAGA	UCUCUUUGGUCAGAAAAGG	Chmp	[1266-1284]
					102	CAUUGCUGAGAACUUUAAG	CUUAAAGUUCUCAGCAAUG	Chmp	[881-899]
103	AGAGUAGAAGUCUCUUCCA	UGGAAGAGACUUCUACUCU	Chmp	[1196-1214]
					104	GUUUCUUGCCUCAUUUUUU	AAAAAAUGAGGCAAGAAAC		[1067-1085]
105	GGGAAGGAAUUUUUCCCAU	AUGGGAAAAAUUCCUUCCC		[429-447]
					106	CAACUUCAACCAUCUCCAG	CUGGAGAUGGUUGAAGUUG	Chmp	[554-572]
107	CUUGGAACUGGAAUCCUUU	AAAGGAUUCCAGUUCCAAG		[1336-1354]
					108	ACGCAUUGCUGAGAACUUU	AAAGUUCUCAGCAAUGCGU	Chmp	[878-896]
109	AGGAUAUGACCACCUUACU	AGUAAGGUGGUCAUAUCCU	Chmp	[925-943]
					110	GUUCCCAGUGACACCAACA	UGUUGGUGUCACUGGGAAC	Chmp	[468-486]
111	ACCUGAAGCUGGACUACCU	AGGUAGUCCAGCUUCAGGU	Chmp	[370-388]
					112	AGCGUGAGGAGCUCUUCAU	AUGAAGAGCUCCUCACGCU	Chmp	[280-298]
113	CCUCAUUUUUUUCCUUGCA	UGCAAGGAAAAAAAUGAGG	Chmp	[1075-1093]
					114	UGGUUCCCAGUGACACCAA	UUGGUGUCACUGGGAACCA	Chmp	[466-484]
115	CCUGGACCUCUACCUUAUU	AAUAAGGUAGAGGUCCAGG	大鼠，Chmp	[386-404]
					116	AGCCUGCAGUUAACCAGAU	AUCUGGUUAACUGCAGGCU	Chmp	[610-628]
117	GUGGAGAUGAUCUUAAACA	UGUUUAAGAUCAUCUCCAC		[573-591]
					118	AGUACAACCUGAAUACCCU	AGGGUAUUCAGGUUGUACU	Chmp	[1250-1268]
119	UACUCAGCUACAACAGGAA	UUCCUGUUGUAGCUGAGUA	大鼠，Ms，Chmp	[940-958]
					120	GAAAGUACAACCUGAAUAC	GUAUUCAGGUUGUACUUUC	Chmp	[1247-1265]
121	CCAUAUCUCACUCAGGAGA	UCUCCUGAGUGAGAUAUGG	Chmp	[639-657]
					122	UUUUUUCCUUGCAAAUGUA	UACAUUUGCAAGGAAAAAA	Chmp	[1081-1099]
123	UGGGACAGCAACCUGUAGA	UCUACAGGUUGCUGUCCCA		[1123-1141]
					124	GGAAGGAAUUUUUCCCAUU	AAUGGGAAAAAUUCCUUCC		[430-448]
125	CUUGAUGUUGGAUCUCAAG	CUUGAGAUCCAACAUCAAG		[1165-1183]
					126	CUGGAAUCCUUUCAGCAAG	CUUGCUGAAAGGAUUCCAG		[1343-1361]
127	UGACCACCUUACUCAGCUA	UAGCUGAGUAAGGUGGUCA	Chmp	[931-949]

128	CAUGAAGAGUUUUGAAGCU	AGCUUCAAAACUCUUCAUG	Chmp	[1011-1029]
					129	CAAUAAAACUACAGCCCAG	CUGGGCUGUAGUUUUAUUG	大鼠，Ms，Chmp	[797-815]
130	GCUACAACAGGAACUGGAG	CUCCAGUUCCUGUUGUAGC	大鼠，Rb，Ms，Chmp	[946-964]
					131	AUCCCAGGAUCAAGGCGAU	AUCGCCUUGAUCCUGGGAU	Chmp	[766-784]
132	CUAGCUUGAUGUUGGAUCU	AGAUCCAACAUCAAGCUAG		[1161-1179]
					133	CCAAGUGACCUAUACCUGU	ACAGGUAUAGGUCACUUGG	Chmp	[1048-1066]
134	UGACUGCUUGGAACUGGAA	UUCCAGUUCCAAGCAGUCA		[1330-1348]
					135	UGCUUUGCCCUUCUUUCUA	UAGAAAGAAGGGCAAAGCA	Chmp	[1218-1236]
136	AGGGUCUGUGCCUUGUUGA	UCAACAAGGCACAGACCCU	Chmp	[963-981]
					137	CAGUGACACCAACAUUCUG	CAGAAUGUUGGUGUCACUG	Chmp	[473-491]
138	GAGUUUUGAAGCUGUGGUU	AACCACAGCUUCAAAACUC	Chmp	[1017-1035]
					139	AAGUAUAAGCCUGCAGUUA	UAACUGCAGGCUUAUACUU	Chmp	[603-621]
140	GUGCACGUACCAUGAGAAG	CUUCUCAUGGUACGUGCAC	Chmp	[314-332]
					141	AGAAGUUAAUCCAGUACUG	CAGUACUGGAUUAACUUCU	Chmp	[655-673]
142	GCCCUGUCAGUAGAGUAGA	UCUACUCUACUGACAGGGC	Chmp	[1185-1203]
					143	CAGGAUAUGACCACCUUAC	GUAAGGUGGUCAUAUCCUG	Chmp	[924-942]
144	GCAGUUAACCAGAUUGAGU	ACUCAAUCUGGUUAACUGC	Chmp	[615-633]
					145	GUGUUUCUUGCCUCAUUUU	AAAAUGAGGCAAGAAACAC		[1065-1083]
146	AGGGCGUGUCUAGCUUGAU	AUCAAGCUAGACACGCCCU		[1152-1170]
					147	AAUUUUUCCCAUUGGAUGA	UCAUCCAAUGGGAAAAAUU		[436-454]
148	GUACAACCUGAAUACCCUU	AAGGGUAUUCAGGUUGUAC	Chmp	[1251-1269]
					149	CACUAACGGUUGAGUUUUG	CAAAACUCAACCGUUAGUG		[1313-1331]
150	ACCUGGACCUCUACCUUAU	AUAAGGUAGAGGUCCAGGU	大鼠，Rb，Chmp	[385-403]
					151	AAUGUGGUUCCCAGUGACA	UGUCACUGGGAACCACAUU	Chmp	[462-480]
152	AGCUACAACAGGAACUGGA	UCCAGUUCCUGUUGUAGCU	大鼠，Rb，Ms，Chmp	[945-963]
					153	CCAAAGAGAAGCAAAAUCU	AGAUUUUGCUUCUCUUUGG	Chmp	[1276-1294]
154	CAGUAGAGUAGAAGUCUCU	AGAGACUUCUACUCUACUG	Chmp	[1192-1210]

155	GUGAGGAGCUCUUCAUCGU	ACGAUGAAGAGCUCCUCAC	Rb，Chmp	[283-301]
					156	UCACUCAGGAGAAGUUAAU	AUUAACUUCUCCUGAGUGA	Chmp	[646-664]
157	AACGCAUUGCUGAGAACUU	AAGUUCUCAGCAAUGCGUU	Chmp	[877-895]
					158	CCAGAACGCAUUGCUGAGA	UCUCAGCAAUGCGUUCUGG	Chmp	[873-891]
159	GUAGAAGUCUCUUCCAGUU	AACUGGAAGAGACUUCUAC	Chmp	[1199-1217]
					160	CUGUCAGUAGAGUAGAAGU	ACUUCUACUCUACUGACAG	Chmp	[1188-1206]
161	AAUACCCUUUUCUGACCAA	UUGGUCAGAAAAGGGUAUU	Chmp	[1261-1279]
					162	CACCCAUAUCUCACUCAGG	CCUGAGUGAGAUAUGGGUG	Chmp	[636-654]
163	GAAGAGUUUUGAAGCUGUG	CACAGCUUCAAAACUCUUC	Chmp	[1014-1032]
					164	CCUUGCAAAUGUAGUAUGG	CCAUACUACAUUUGCAAGG	Chmp	[1087-1105]
165	UUGACUGCUUGGAACUGGA	UCCAGUUCCAAGCAGUCAA		[1329-1347]
					166	UGUUGAGCUGUACCUCCCA	UGGGAGGUACAGCUCAACA	Chmp	[976-994]
167	AGUCCAAAGGCAUCGUGGU	ACCACGAUGCCUUUGGACU	Chmp	[676-694]
					168	CUGUACCUCCCACAAGGAU	AUCCUUGUGGGAGGUACAG	Chmp	[983-1001]
169	GCUUUAAGCCUGGGAAGGA	UCCUUCCCAGGCUUAAAGC	Chmp	[418-436]
					170	AGCAAAAUCUACCAGGUCA	UGACCUGGUAGAUUUUGCU	Chmp	[1285-1303]
171	UGUGCCUUGUUGAGCUGUA	UACAGCUCAACAAGGCACA	Chmp	[969-987]
					172	AUACCCUUUUCUGACCAAA	UUUGGUCAGAAAAGGGUAU	Chmp	[1262-1280]
173	UGAAGCUGGACUACCUGGA	UCCAGGUAGUCCAGCUUCA	Chmp	[373-391]
					174	AGGAGCUCUUCAUCGUCAG	CUGACGAUGAAGAGCUCCU	Rb，Chmp	[286-304]
175	UGAUGUUGGAUCUCAAGAG	CUCUUGAGAUCCAACAUCA	Chmp	[1167-1185]
					176	CCCUUUUCUGACCAAAGAG	CUCUUUGGUCAGAAAAGGG	Chmp	[1265-1283]
177	UCUCCAACUUCAACCAUCU	AGAUGGUUGAAGUUGGAGA	Chmp	[550-568]
					178	CCCAUAUCUCACUCAGGAG	CUCCUGAGUGAGAUAUGGG	Chmp	[638-656]
179	CUUUCAGCAAGACUUCUCU	AGAGAAGUCUUGCUGAAAG	Chmp	[1351-1369]
					180	UGAAGAGUUUUGAAGCUGU	ACAGCUUCAAAACUCUUCA	Chmp	[1013-1031]
181	GUACCAGAAUGAGAAUGAG	CUCAUUCUCAUUCUGGUAC	Chmp	[218-236]

182	GGCGUGUCUAGCUUGAUGU	ACAUCAAGCUAGACACGCC		[1154-1172]
					183	CAACCUGAAUACCCUUUUC	GAAAAGGGUAUUCAGGUUG	Chmp	[1254-1272]
184	CAGCAAGACUUCUCUUUGC	GCAAAGAGAAGUCUUGCUG	Chmp	[1355-1373]
					185	UUUCUUGCCUCAUUUUUUU	AAAAAAAUGAGGCAAGAAA		[1068-1086]
186	GAACUUUAAGGUCUUUGAC	GUCAAAGACCUUAAAGUUC	大鼠，Chmp	[890-908]
					187	UCUCAAGAGCCCUGUCAGU	ACUGACAGGGCUCUUGAGA	Chmp	[1177-1195]
188	CAUCUCCAACUUCAACCAU	AUGGUUGAAGUUGGAGAUG	Chmp	[548-566]
					189	CAGUUUGCUUUGCCCUUCU	AGAAGGGCAAAGCAAACUG	Chmp	[1213-1231]
190	UUCCCAGUGACACCAACAU	AUGUUGGUGUCACUGGGAA	Chmp	[469-487]
					191	GAGAUGAUCUUAAACAAAC	GUUUGUUUAAGAUCAUCUC		[576-594]
192	CCUUCUUUCUACCCUGCUG	CAGCAGGGUAGAAAGAAGG	Chmp	[1226-1244]
					193	CUACCAGGUCAAAAUAGUG	CACUAUUUUGACCUGGUAG	Chmp	[1293-1311]
194	GGAGAAGUUAAUCCAGUAC	GUACUGGAUUAACUUCUCC	Chmp	[653-671]
					195	AGAUGAUCUUAAACAAACC	GGUUUGUUUAAGAUCAUCU		[577-595]
196	AGCCUGGGAAGGAAUUUUU	AAAAAUUCCUUCCCAGGCU	Chmp	[424-442]
					197	GGACCUCUACCUUAUUCAC	GUGAAUAAGGUAGAGGUCC	大鼠，Chmp	[389-407]
198	GAAUCCUUUCAGCAAGACU	AGUCUUGCUGAAAGGAUUC		[1346-1364]
					199	AAUCCUUUCAGCAAGACUU	AAGUCUUGCUGAAAGGAUU	Chmp	[1347-1365]
200	ACUAACGGUUGAGUUUUGA	UCAAAACUCAACCGUUAGU		[1314-1332]
					201	UCUACCAGGUCAAAAUAGU	ACUAUUUUGACCUGGUAGA	Chmp	[1292-1310]
202	UCCCAGUGACACCAACAUU	AAUGUUGGUGUCACUGGGA	Chmp	[470-488]
					203	UGAAGUAUAAGCCUGCAGU	ACUGCAGGCUUAUACUUCA	Chmp	[601-619]
204	AACUGGAAUCCUUUCAGCA	UGCUGAAAGGAUUCCAGUU		[1341-1359]
					205	GGAACUGGAAUCCUUUCAG	CUGAAAGGAUUCCAGUUCC		[1339-1357]
206	ACCUUACUCAGCUACAACA	UGUUGUAGCUGAGUAAGGU	Chmp	[936-954]
					207	CCACUAACGGUUGAGUUUU	AAAACUCAACCGUUAGUGG		[1312-1330]
208	AGCUUGAUGUUGGAUCUCA	UGAGAUCCAACAUCAAGCU		[1163-1181]

209	GCAAGACUUCUCUUUGCCU	AGGCAAAGAGAAGUCUUGC	Chmp	[1357-1375]
					210	CAGAGGAACUUGGUGGUGA	UCACCACCAAGUUCCUCUG	Chmp	[837-855]
211	GGACAGCAACCUGUAGAGU	ACUCUACAGGUUGCUGUCC	Chmp	[1125-1143]
					212	UCAGGAGAAGUUAAUCCAG	CUGGAUUAACUUCUCCUGA	Chmp	[650-668]
213	GAAUACCCUUUUCUGACCA	UGGUCAGAAAAGGGUAUUC	Chmp	[1260-1278]
					214	UGGGAAGGAAUUUUUCCCA	UGGGAAAAAUUCCUUCCCA		[428-446]
215	UUAAGGUCUUUGACUUUGA	UCAAAGUCAAAGACCUUAA	大鼠，Chmp	[895-913]
					216	GACUGCUUGGAACUGGAAU	AUUCCAGUUCCAAGCAGUC		[1331-1349]
217	GAUCUCAAGAGCCCUGUCA	UGACAGGGCUCUUGAGAUC	Chmp	[1175-1193]
					218	AUUGGAUGAGUCGGGCAAU	AUUGCCCGACUCAUCCAAU		[446-464]
219	GUCUUUGACUUUGAACUGA	UCAGUUCAAAGUCAAAGAC	Rb，Chmp	[900-918]
					220	AAAAUCUACCAGGUCAAAA	UUUUGACCUGGUAGAUUUU	Chmp	[1288-1306]
221	CGGUUGAGUUUUGACUGCU	AGCAGUCAAAACUCAACCG		[1319-1337]
					222	CUCAAGAGCCCUGUCAGUA	UACUGACAGGGCUCUUGAG	Chmp	[1178-1196]
223	CCAAGCACAAUAAAACUAC	GUAGUUUUAUUGUGCUUGG	Chmp	[790-808]
					224	AUCUCCAGGUGGAGAUGAU	AUCAUCUCCACCUGGAGAU		[565-583]
225	ACAAUAAAACUACAGCCCA	UGGGCUGUAGUUUUAUUGU	大鼠，Ms，Chmp	[796-814]
					226	UGAGAACUUUAAGGUCUUU	AAAGACCUUAAAGUUCUCA	大鼠，Chmp	[887-905]
227	AGAACGCAUUGCUGAGAAC	GUUCUCAGCAAUGCGUUCU	Chmp	[875-893]
					228	UCUCACUCAGGAGAAGUUA	UAACUUCUCCUGAGUGAGA	Chmp	[644-662]
229	GCCUGGGAAGGAAUUUUUC	GAAAAAUUCCUUCCCAGGC	Chmp	[425-443]
					230	GGAUAUGACCACCUUACUC	GAGUAAGGUGGUCAUAUCC	Chmp	[926-944]
231	CUUGCCUCAUUUUUUUCCU	AGGAAAAAAAUGAGGCAAG		[1071-1089]
					232	GAGUAGAAGUCUCUUCCAG	CUGGAAGAGACUUCUACUC	Chmp	[1197-1215]
233	AGUAGAAGUCUCUUCCAGU	ACUGGAAGAGACUUCUACU	Chmp	[1198-1216]
					234	ACCUGAAUACCCUUUUCUG	CAGAAAAGGGUAUUCAGGU	Chmp	[1256-1274]
235	UUCUGACCAAAGAGAAGCA	UGCUUCUCUUUGGUCAGAA	Chmp	[1270-1288]

236	GAUAUGACCACCUUACUCA	UGAGUAAGGUGGUCAUAUC	Chmp	[927-945]
					237	UGAGUUUUGACUGCUUGGA	UCCAAGCAGUCAAAACUCA	Chmp	[1323-1341]
238	ACCAGAACGCAUUGCUGAG	CUCAGCAAUGCGUUCUGGU	Chmp	[872-890]
					239	UCAACCAUCUCCAGGUGGA	UCCACCUGGAGAUGGUUGA	Chmp	[559-577]
240	CUACCUGGACCUCUACCUU	AAGGUAGAGGUCCAGGUAG	大鼠，Rb，Chmp	[383-401]
					241	GGCUUGAAGUAUAAGCCUG	CAGGCUUAUACUUCAAGCC	Chmp	[597-615]
242	CCCAGUGACACCAACAUUC	GAAUGUUGGUGUCACUGGG	Chmp	[471-489]
					243	CCAUGAAGAGUUUUGAAGC	GCUUCAAAACUCUUCAUGG	Chmp	[1010-1028]
244	UCUGACCAAAGAGAAGCAA	UUGCUUCUCUUUGGUCAGA	Chmp	[1271-1289]
					245	GGCUGGUGAAAGCUAUUGG	CCAAUAGCUUUCACCAGCC	Chmp	[529-547]
246	UGCCCUUCUUUCUACCCUG	CAGGGUAGAAAGAAGGGCA	Chmp	[1223-1241]
					247	CCAACAUUCUGGACACGUG	CACGUGUCCAGAAUGUUGG	Chmp	[481-499]
248	UCCAGGUGGAGAUGAUCUU	AAGAUCAUCUCCACCUGGA		[568-586]
					249	GAGAAGUUAAUCCAGUACU	AGUACUGGAUUAACUUCUC	Chmp	[654-672]
250	GAAGGAAUUUUUCCCAUUG	CAAUGGGAAAAAUUCCUUC		[431-449]
					251	AAGACACUCAGCGACCUGA	UCAGGUCGCUGAGUGUCUU	Chmp	[357-375]
252	GAAUUUUUCCCAUUGGAUG	CAUCCAAUGGGAAAAAUUC		[435-453]
					253	GCUGAGAACUUUAAGGUCU	AGACCUUAAAGUUCUCAGC	大鼠，Chmp	[885-903]
254	AGUUUGCUUUGCCCUUCUU	AAGAAGGGCAAAGCAAACU	Chmp	[1214-1232]
					255	UGAAGCGUGAGGAGCUCUU	AAGAGCUCCUCACGCUUCA	Chmp	[277-295]
256	UUGAUGUUGGAUCUCAAGA	UCUUGAGAUCCAACAUCAA	Chmp	[1166-1184]
					257	AUGAGUCGGGCAAUGUGGU	ACCACAUUGCCCGACUCAU	Chmp	[451-469]
258	GAUGAUCUUAAACAAACCU	AGGUUUGUUUAAGAUCAUC		[578-596]
					259	GUGUCUAGCUUGAUGUUGG	CCAACAUCAAGCUAGACAC		[1157-1175]
260	AGUAGAGUAGAAGUCUCUU	AAGAGACUUCUACUCUACU	Chmp	[1193-1211]
					261	UGCAGUUAACCAGAUUGAG	CUCAAUCUGGUUAACUGCA	Chmp	[614-632]
262	CCAUUCAGGAGAAGCUCAG	CUGAGCUUCUCCUGAAUGG	Chmp	[247-265]

263	GGUCUUUGACUUUGAACUG	CAGUUCAAAGUCAAAGACC	Rb，Chmp	[899-917]
					264	AGUUUUGACUGCUUGGAAC	GUUCCAAGCAGUCAAAACU	Chmp	[1325-1343]
265	AAGCACAAUAAAACUACAG	CUGUAGUUUUAUUGUGCUU	Chmp	[792-810]
					266	AAAGAGAAGCAAAAUCUAC	GUAGAUUUUGCUUCUCUUU	Chmp	[1278-1296]
267	GCUUUGCCCUUCUUUCUAC	GUAGAAAGAAGGGCAAAGC	Chmp	[1219-1237]
					268	ACGGGCUAUUUAAAGGUAC	GUACCUUUAAAUAGCCCGU		[1-19]
269	CCCUUCUUUCUACCCUGCU	AGCAGGGUAGAAAGAAGGG	Chmp	[1225-1243]
					270	UGGACCUCUACCUUAUUCA	UGAAUAAGGUAGAGGUCCA	大鼠，Chmp	[388-406]
271	GAUGUUGGAUCUCAAGAGC	GCUCUUGAGAUCCAACAUC	Chmp	[1168-1186]
					272	CCAGAAUGAGAAUGAGGUG	CACCUCAUUCUCAUUCUGG	Chmp	[221-239]
273	GUGCCUUGUUGAGCUGUAC	GUACAGCUCAACAAGGCAC	Chmp	[970-988]
					274	AGGUCUUUGACUUUGAACU	AGUUCAAAGUCAAAGACCU	Rb，Chmp	[898-916]
275	AUAAGCCUGCAGUUAACCA	UGGUUAACUGCAGGCUUAU	Chmp	[607-625]
					276	UGUACCUCCCACAAGGAUU	AAUCCUUGUGGGAGGUACA	Chmp	[984-1002]
277	UGUGACACCAGAACGCAUU	AAUGCGUUCUGGUGUCACA	Chmp	[866-884]
					278	CUGAAUACCCUUUUCUGAC	GUCAGAAAAGGGUAUUCAG	Chmp	[1258-1276]
279	UCAAGAGCCCUGUCAGUAG	CUACUGACAGGGCUCUUGA	Chmp	[1179-1197]
					280	UGGAACUGGAAUCCUUUCA	UGAAAGGAUUCCAGUUCCA		[1338-1356]
281	GCACAAUAAAACUACAGCC	GGCUGUAGUUUUAUUGUGC	Chmp	[794-812]
					282	AACAGGAACUGGAGGGUCU	AGACCCUCCAGUUCCUGUU	Rb，Chmp	[951-969]
283	GACACCAGAACGCAUUGCU	AGCAAUGCGUUCUGGUGUC	Chmp	[869-887]
					284	UGAGUCGGGCAAUGUGGUU	AACCACAUUGCCCGACUCA	Chmp	[452-470]
285	UGUUUCUUGCCUCAUUUUU	AAAAAUGAGGCAAGAAACA		[1066-1084]
					286	UUACUCAGCUACAACAGGA	UCCUGUUGUAGCUGAGUAA	Chmp	[939-957]
287	CACCUUACUCAGCUACAAC	GUUGUAGCUGAGUAAGGUG	Chmp	[935-953]
					288	AGAAGACACUCAGCGACCU	AGGUCGCUGAGUGUCUUCU	Chmp	[355-373]
289	CAAGUGACCUAUACCUGUG	CACAGGUAUAGGUCACUUG	Chmp	[1049-1067]

290	GUUUGCUUUGCCCUUCUUU	AAAGAAGGGCAAAGCAAAC	Chmp	[1215-1233]
					291	GAUGAAGGGCUGGUGAAAG	CUUUCACCAGCCCUUCAUC	Chmp	[522-540]
292	ACACCAGAACGCAUUGCUG	CAGCAAUGCGUUCUGGUGU	Chmp	[870-888]
					293	CCUUACUCAGCUACAACAG	CUGUUGUAGCUGAGUAAGG	Chmp	[937-955]
294	GCUCUUCAUCGUCAGCAAG	CUUGCUGACGAUGAAGAGC	Rb，Chmp	[290-308]
					295	UCUGUGACACCAGAACGCA	UGCGUUCUGGUGUCACAGA	Chmp	[864-882]
296	GUCAGUAGAGUAGAAGUCU	AGACUUCUACUCUACUGAC	Chmp	[1190-1208]
					297	CUUUGACUUUGAACUGAGC	GCUCAGUUCAAAGUCAAAG	Rb，Chmp	[902-920]
298	CUUUAAGGUCUUUGACUUU	AAAGUCAAAGACCUUAAAG	大鼠，Chmp	[893-911]
					299	UGGAUGAGUCGGGCAAUGU	ACAUUGCCCGACUCAUCCA	Chmp	[448-466]
300	GCCUCAUUUUUUUCCUUGC	GCAAGGAAAAAAAUGAGGC	Chmp	[1074-1092]
					301	ACUUUAAGGUCUUUGACUU	AAGUCAAAGACCUUAAAGU	大鼠，Chmp	[892-910]
302	GCUUGAAGUAUAAGCCUGC	GCAGGCUUAUACUUCAAGC	Chmp	[598-616]
					303	GUCUGUGCCUUGUUGAGCU	AGCUCAACAAGGCACAGAC	Chmp	[966-984]
304	GAACGCAUUGCUGAGAACU	AGUUCUCAGCAAUGCGUUC	Chmp	[876-894]
					305	CACUCAGGAGAAGUUAAUC	GAUUAACUUCUCCUGAGUG	Chmp	[647-665]
306	AAGCCUGGGAAGGAAUUUU	AAAAUUCCUUCCCAGGCUU	Chmp	[423-441]
					307	UACCCUUUUCUGACCAAAG	CUUUGGUCAGAAAAGGGUA	Chmp	[1263-1281]
308	ACCACCUUACUCAGCUACA	UGUAGCUGAGUAAGGUGGU	Chmp	[933-951]
					309	ACAGCAACCUGUAGAGUGG	CCACUCUACAGGUUGCUGU	Chmp	[1127-1145]
310	CAGUUAACCAGAUUGAGUG	CACUCAAUCUGGUUAACUG	Chmp	[616-634]
					311	UGUACCAGAAUGAGAAUGA	UCAUUCUCAUUCUGGUACA	Chmp	[217-235]
312	UUGCUUUGCCCUUCUUUCU	AGAAAGAAGGGCAAAGCAA	Chmp	[1217-1235]
					313	AUCUCACUCAGGAGAAGUU	AACUUCUCCUGAGUGAGAU	Chmp	[643-661]
314	GAACUGGAAUCCUUUCAGC	GCUGAAAGGAUUCCAGUUC		[1340-1358]
					315	GUCUCUUCCAGUUUGCUUU	AAAGCAAACUGGAAGAGAC	Chmp	[1205-1223]
316	UUCAGGAGAAGCUCAGGGA	UCCCUGAGCUUCUCCUGAA	Chmp	[250-268]

317	CUAACGGUUGAGUUUUGAC	GUCAAAACUCAACCGUUAG		[1315-1333]
					318	UUGCCUCAUUUUUUUCCUU	AAGGAAAAAAAUGAGGCAA		[1072-1090]
319	GGAAUCCUUUCAGCAAGAC	GUCUUGCUGAAAGGAUUCC		[1345-1363]
					320	AAGGAAUUUUUCCCAUUGG	CCAAUGGGAAAAAUUCCUU		[432-450]
321	UGAUCUUAAACAAACCUGG	CCAGGUUUGUUUAAGAUCA		[580-598]
					322	GUGACACCAGAACGCAUUG	CAAUGCGUUCUGGUGUCAC	Chmp	[867-885]
323	UACCUGGACCUCUACCUUA	UAAGGUAGAGGUCCAGGUA	大鼠，Rb，Chmp	[384-402]
					324	AUAUGACCACCUUACUCAG	CUGAGUAAGGUGGUCAUAU	Chmp	[928-946]
325	CAUGCAGAGGAACUUGGUG	CACCAAGUUCCUCUGCAUG	Chmp	[833-851]
					326	CCCUUCCAUGAAGAGUUUU	AAAACUCUUCAUGGAAGGG	Chmp	[1005-1023]
327	AGCCCUGUCAGUAGAGUAG	CUACUCUACUGACAGGGCU	Chmp	[1184-1202]
					328	AGAGCCCUGUCAGUAGAGU	ACUCUACUGACAGGGCUCU	Chmp	[1182-1200]
329	UUGAGCUGUACCUCCCACA	UGUGGGAGGUACAGCUCAA	Chmp	[978-996]
					330	UUUUCCUUGCAAAUGUAGU	ACUACAUUUGCAAGGAAAA	Chmp	[1083-1101]
331	GAGCUCUUCAUCGUCAGCA	UGCUGACGAUGAAGAGCUC	Rb，Chmp	[288-306]
					332	ACACCAACAUUCUGGACAC	GUGUCCAGAAUGUUGGUGU	Chmp	[478-496]
333	AAGAGCUGGUGGAUGAAGG	CCUUCAUCCACCAGCUCUU	Chmp	[511-529]
					334	AGAGUUUUGAAGCUGUGGU	ACCACAGCUUCAAAACUCU	Chmp	[1016-1034]
335	AAGUCUGUGACACCAGAAC	GUUCUGGUGUCACAGACUU	Chmp	[861-879]
					336	CCUUCCAUGAAGAGUUUUG	CAAAACUCUUCAUGGAAGG	Chmp	[1006-1024]
337	GUUGGAUCUCAAGAGCCCU	AGGGCUCUUGAGAUCCAAC	Chmp	[1171-1189]
					338	UGCAGAGGAACUUGGUGGU	ACCACCAAGUUCCUCUGCA	Chmp	[835-853]
339	GCCUUGUUGAGCUGUACCU	AGGUACAGCUCAACAAGGC	Chmp	[972-990]
					340	CCUGCAGUUAACCAGAUUG	CAAUCUGGUUAACUGCAGG	Chmp	[612-630]
341	ACUUCAACCAUCUCCAGGU	ACCUGGAGAUGGUUGAAGU	Chmp	[556-574]
					342	UGAAGGGCUGGUGAAAGCU	AGCUUUCACCAGCCCUUCA	Chmp	[524-542]
343	UCUUUGACUUUGAACUGAG	CUCAGUUCAAAGUCAAAGA	Rb，Chmp	[901-919]

344	AUCUCAAGAGCCCUGUCAG	CUGACAGGGCUCUUGAGAU	Chmp	[1176-1194]
					345	UUUUUUUCCUUGCAAAUGU	ACAUUUGCAAGGAAAAAAA	Chmp	[1080-1098]
346	ACAACCUGAAUACCCUUUU	AAAAGGGUAUUCAGGUUGU	Chmp	[1253-1271]
					347	UCUUCAUCGUCAGCAAGCU	AGCUUGCUGACGAUGAAGA	Rb，Chmp	[292-310]
348	AUAUCUCACUCAGGAGAAG	CUUCUCCUGAGUGAGAUAU	Chmp	[641-659]
					349	GAAGAGCUGGUGGAUGAAG	CUUCAUCCACCAGCUCUUC	Chmp	[510-528]
350	UGAGGAGCUCUUCAUCGUC	GACGAUGAAGAGCUCCUCA	Rb，Chmp	[284-302]
					351	CUCCAGGUGGAGAUGAUCU	AGAUCAUCUCCACCUGGAG		[567-585]
352	ACCAGAAUGAGAAUGAGGU	ACCUCAUUCUCAUUCUGGU	Chmp	[220-238]
					353	CCUGGGAAGGAAUUUUUCC	GGAAAAAUUCCUUCCCAGG	Chmp	[426-444]
354	UUUAAGCCUGGGAAGGAAU	AUUCCUUCCCAGGCUUAAA	Chmp	[420-438]
					355	UAACGGUUGAGUUUUGACU	AGUCAAAACUCAACCGUUA		[1316-1334]
356	UUGGAUGAGUCGGGCAAUG	CAUUGCCCGACUCAUCCAA	Chmp	[447-465]
					357	CCCAAGUGACCUAUACCUG	CAGGUAUAGGUCACUUGGG	Chmp	[1047-1065]
358	GCUAUUUAAAGGUACGCGC	GCGCGUACCUUUAAAUAGC		[5-23]
					359	CAACAUUCUGGACACGUGG	CCACGUGUCCAGAAUGUUG	Chmp	[482-500]
360	AAACUACAGCCCAGGUCCU	AGGACCUGGGCUGUAGUUU	Chmp	[802-820]
					361	CAUUCAGGAGAAGCUCAGG	CCUGAGCUUCUCCUGAAUG	Chmp	[248-266]
362	AACCUGAAUACCCUUUUCU	AGAAAAGGGUAUUCAGGUU	Chmp	[1255-1273]
					363	UCAGCAAGACUUCUCUUUG	CAAAGAGAAGUCUUGCUGA	Chmp	[1354-1372]
364	GUUUUGACUGCUUGGAACU	AGUUCCAAGCAGUCAAAAC	Chmp	[1326-1344]
					365	UUUCAGCAAGACUUCUCUU	AAGAGAAGUCUUGCUGAAA	Chmp	[1352-1370]
366	AAGAGAAGCAAAAUCUACC	GGUAGAUUUUGCUUCUCUU	Chmp	[1279-1297]
					367	ACAUCGACUGUGCCCAUGU	ACAUGGGCACAGUCGAUGU	Chmp	[199-217]
368	UCAGUAGAGUAGAAGUCUC	GAGACUUCUACUCUACUGA	Chmp	[1191-1209]
					369	CUCCAACUUCAACCAUCUC	GAGAUGGUUGAAGUUGGAG	Chmp	[551-569]
370	UAAGCCUGCAGUUAACCAG	CUGGUUAACUGCAGGCUUA	Chmp	[608-626]

371	GACAGCAACCUGUAGAGUG	CACUCUACAGGUUGCUGUC	Chmp	[1126-1144]
					372	UUCCUUGCAAAUGUAGUAU	AUACUACAUUUGCAAGGAA	Chmp	[1085-1103]
373	UUUUCUGACCAAAGAGAAG	CUUCUCUUUGGUCAGAAAA	Chmp	[1268-1286]
					374	CCUUUCAGCAAGACUUCUC	GAGAAGUCUUGCUGAAAGG	Chmp	[1350-1368]
375	GAAGUCUCUUCCAGUUUGC	GCAAACUGGAAGAGACUUC	Chmp	[1202-1220]
					376	GUUGAGUUUUGACUGCUUG	CAAGCAGUCAAAACUCAAC	Chmp	[1321-1339]
377	GGGCUAUUUAAAGGUACGC	GCGUACCUUUAAAUAGCCC		[3-21]
					378	CUUCAACCAUCUCCAGGUG	CACCUGGAGAUGGUUGAAG	Chmp	[557-575]
379	CUCAGCUACAACAGGAACU	AGUUCCUGUUGUAGCUGAG	大鼠，Ms，Chmp	[942-960]
					380	UCCUUUCAGCAAGACUUCU	AGAAGUCUUGCUGAAAGGA	Chmp	[1349-1367]
381	CUAUUUAAAGGUACGCGCC	GGCGCGUACCUUUAAAUAG		[6-24]
					382	AGCACAAUAAAACUACAGC	GCUGUAGUUUUAUUGUGCU	Chmp	[793-811]
383	AACUUUAAGGUCUUUGACU	AGUCAAAGACCUUAAAGUU	大鼠，Chmp	[891-909]
					384	GGCAUCUCCAACUUCAACC	GGUUGAAGUUGGAGAUGCC	Chmp	[546-564]
385	UCAUCGUCAGCAAGCUGUG	CACAGCUUGCUGACGAUGA	Rb，Chmp	[295-313]
					386	GGCUAUUUAAAGGUACGCG	CGCGUACCUUUAAAUAGCC		[4-22]
387	GUCUAGCUUGAUGUUGGAU	AUCCAACAUCAAGCUAGAC		[1159-1177]
					388	UUAAGCCUGGGAAGGAAUU	AAUUCCUUCCCAGGCUUAA	Chmp	[421-439]
389	GACACCAACAUUCUGGACA	UGUCCAGAAUGUUGGUGUC	Chmp	[477-495]
					390	CUACAACAGGAACUGGAGG	CCUCCAGUUCCUGUUGUAG	大鼠，Rb，Ms，Chmp	[947-965]
391	GAGAAGCAAAAUCUACCAG	CUGGUAGAUUUUGCUUCUC	Chmp	[1281-1299]
					392	ACCAUCUCCAGGUGGAGAU	AUCUCCACCUGGAGAUGGU		[562-580]
393	CAUCUCCAGGUGGAGAUGA	UCAUCUCCACCUGGAGAUG		[564-582]
					394	GACCUCUACCUUAUUCACU	AGUGAAUAAGGUAGAGGUC	大鼠，Chmp	[390-408]
395	AGUCUCUUCCAGUUUGCUU	AAGCAAACUGGAAGAGACU	Chmp	[1204-1222]
					396	GAAGUUAAUCCAGUACUGC	GCAGUACUGGAUUAACUUC	Chmp	[656-674]
397	AAGAGCCCUGUCAGUAGAG	CUCUACUGACAGGGCUCUU	Chmp	[1181-1199]

398	CAAGACUUCUCUUUGCCUC	GAGGCAAAGAGAAGUCUUG	Chmp	[1358-1376]
					399	UCCAAAGGCAUCGUGGUGA	UCACCACGAUGCCUUUGGA	Chmp	[678-696]
400	AACCAUCUCCAGGUGGAGA	UCUCCACCUGGAGAUGGUU	Chmp	[561-579]
					401	GGGCUGGUGAAAGCUAUUG	CAAUAGCUUUCACCAGCCC	Chmp	[528-546]
402	UAAGCCUGGGAAGGAAUUU	AAAUUCCUUCCCAGGCUUA	Chmp	[422-440]
					403	AUCCUUUCAGCAAGACUUC	GAAGUCUUGCUGAAAGGAU	Chmp	[1348-1366]
404	CAGCUACAACAGGAACUGG	CCAGUUCCUGUUGUAGCUG	大鼠，Ms，Chmp	[944-962]
					405	ACAACAGGAACUGGAGGGU	ACCCUCCAGUUCCUGUUGU	大鼠，Rb，Ms，Chmp	[949-967]
406	UGCUGAGAACUUUAAGGUC	GACCUUAAAGUUCUCAGCA	大鼠，Chmp	[884-902]
					407	AUGAAGGGCUGGUGAAAGC	GCUUUCACCAGCCCUUCAU	Chmp	[523-541]
408	AGAAGUCUCUUCCAGUUUG	CAAACUGGAAGAGACUUCU	Chmp	[1201-1219]
					409	ACCUCUACCUUAUUCACUG	CAGUGAAUAAGGUAGAGGU	大鼠，Chmp	[391-409]
410	AAGUCUCUUCCAGUUUGCU	AGCAAACUGGAAGAGACUU	Chmp	[1203-1221]
					411	CGUGUCUAGCUUGAUGUUG	CAACAUCAAGCUAGACACG		[1156-1174]
412	CUUUGCCCUUCUUUCUACC	GGUAGAAAGAAGGGCAAAG	Chmp	[1220-1238]
					413	AAGUUAAUCCAGUACUGCC	GGCAGUACUGGAUUAACUU	Chmp	[657-675]
414	UCCAUGAAGAGUUUUGAAG	CUUCAAAACUCUUCAUGGA	Chmp	[1009-1027]
					415	AACGGUUGAGUUUUGACUG	CAGUCAAAACUCAACCGUU		[1317-1335]
416	CUUCUUUCUACCCUGCUGG	CCAGCAGGGUAGAAAGAAG	Chmp	[1227-1245]
					417	ACCAAAGAGAAGCAAAAUC	GAUUUUGCUUCUCUUUGGU	Chmp	[1275-1293]
418	CCUGUCAGUAGAGUAGAAG	CUUCUACUCUACUGACAGG	Chmp	[1187-1205]
					419	CUUCAUCGUCAGCAAGCUG	CAGCUUGCUGACGAUGAAG	Rb，Chmp	[293-311]
420	AAGGUCUUUGACUUUGAAC	GUUCAAAGUCAAAGACCUU	Chmp	[897-915]
					421	AUGUGGUUCCCAGUGACAC	GUGUCACUGGGAACCACAU	Chmp	[463-481]
422	UCCAGUUUGCUUUGCCCUU	AAGGGCAAAGCAAACUGGA	Chmp	[1211-1229]
					423	CUGGGAAGGAAUUUUUCCC	GGGAAAAAUUCCUUCCCAG	Chmp	[427-445]
424	UUUGACUUUGAACUGAGCA	UGCUCAGUUCAAAGUCAAA	Rb，Chmp	[903-921]

425	GAGGAACUUGGUGGUGAUC	GAUCACCACCAAGUUCCUC	Chmp	[839-857]
					426	UUGCCCUUCUUUCUACCCU	AGGGUAGAAAGAAGGGCAA	Chmp	[1222-1240]
427	UGUUGGAUCUCAAGAGCCC	GGGCUCUUGAGAUCCAACA	Chmp	[1170-1188]
					428	UGCUUGGAACUGGAAUCCU	AGGAUUCCAGUUCCAAGCA		[1334-1352]
429	UCCUUGCAAAUGUAGUAUG	CAUACUACAUUUGCAAGGA	Chmp	[1086-1104]
					430	GACUUUGAACUGAGCAGCC	GGCUGCUCAGUUCAAAGUC	Chmp	[906-924]
431	AGUCUGUGACACCAGAACG	CGUUCUGGUGUCACAGACU	Chmp	[862-880]
					432	CACCAACAUUCUGGACACG	CGUGUCCAGAAUGUUGGUG	Chmp	[479-497]
433	CCUUGUUGAGCUGUACCUC	GAGGUACAGCUCAACAAGG	Chmp	[973-991]
					434	ACGGUUGAGUUUUGACUGC	GCAGUCAAAACUCAACCGU		[1318-1336]
435	UUGCUGAGAACUUUAAGGU	ACCUUAAAGUUCUCAGCAA	大鼠，Chmp	[883-901]
					436	UUGAGUUUUGACUGCUUGG	CCAAGCAGUCAAAACUCAA	Chmp	[1322-1340]
437	CCUCUACCUUAUUCACUGG	CCAGUGAAUAAGGUAGAGG	大鼠，Chmp	[392-410]
					438	CUUACUCAGCUACAACAGG	CCUGUUGUAGCUGAGUAAG	Chmp	[938-956]
439	UUGACUUUGAACUGAGCAG	CUGCUCAGUUCAAAGUCAA	Rb，Chmp	[904-922]
					440	AAGCAAAAUCUACCAGGUC	GACCUGGUAGAUUUUGCUU	Chmp	[1284-1302]
441	AUCUACCAGGUCAAAAUAG	CUAUUUUGACCUGGUAGAU	Chmp	[1291-1309]
					442	CUUCCAGUUUGCUUUGCCC	GGGCAAAGCAAACUGGAAG	Chmp	[1209-1227]
443	AUAAAACUACAGCCCAGGU	ACCUGGGCUGUAGUUUUAU	大鼠，Ms，Chmp	[799-817]
					444	AGCAAGACUUCUCUUUGCC	GGCAAAGAGAAGUCUUGCU	Chmp	[1356-1374]
445	UGGAUCUCAAGAGCCCUGU	ACAGGGCUCUUGAGAUCCA	Chmp	[1173-1191]
					446	AAAGUACAACCUGAAUACC	GGUAUUCAGGUUGUACUUU	Chmp	[1248-1266]
447	UUCAGCAAGACUUCUCUUU	AAAGAGAAGUCUUGCUGAA	Chmp	[1353-1371]
					448	UUUGCUUUGCCCUUCUUUC	GAAAGAAGGGCAAAGCAAA	Chmp	[1216-1234]
449	AGAAGCAAAAUCUACCAGG	CCUGGUAGAUUUUGCUUCU	Chmp	[1282-1300]
					450	GUAGAGUAGAAGUCUCUUC	GAAGAGACUUCUACUCUAC	Chmp	[1194-1212]
451	UGCACGUACCAUGAGAAGG	CCUUCUCAUGGUACGUGCA	Chmp	[315-333]

452	AUUGCUGAGAACUUUAAGG	CCUUAAAGUUCUCAGCAAU	大鼠，Chmp	[882-900]
					453	ACUACCUGGACCUCUACCU	AGGUAGAGGUCCAGGUAGU	大鼠，Rb，Chmp	[382-400]
454	UAGAAGUCUCUUCCAGUUU	AAACUGGAAGAGACUUCUA	Chmp	[1200-1218]
					455	AAGUACAACCUGAAUACCC	GGGUAUUCAGGUUGUACUU	Chmp	[1249-1267]
456	AUCUCCAACUUCAACCAUC	GAUGGUUGAAGUUGGAGAU	Chmp	[549-567]
					457	UGAAUACCCUUUUCUGACC	GGUCAGAAAAGGGUAUUCA	Chmp	[1259-1277]
458	CACAAUAAAACUACAGCCC	GGGCUGUAGUUUUAUUGUG	Chmp	[795-813]
					459	ACUGCUUGGAACUGGAAUC	GAUUCCAGUUCCAAGCAGU		[1332-1350]
460	CCAGUUUGCUUUGCCCUUC	GAAGGGCAAAGCAAACUGG	Chmp	[1212-1230]
					461	UUGGAACUGGAAUCCUUUC	GAAAGGAUUCCAGUUCCAA		[1337-1355]
462	UGUCAGUAGAGUAGAAGUC	GACUUCUACUCUACUGACA	Chmp	[1189-1207]
					463	UUGAAGUAUAAGCCUGCAG	CUGCAGGCUUAUACUUCAA	Chmp	[600-618]
464	UCAGCUACAACAGGAACUG	CAGUUCCUGUUGUAGCUGA	大鼠，Ms，Chmp	[943-961]
					465	UCUCCAGGUGGAGAUGAUC	GAUCAUCUCCACCUGGAGA		[566-584]
466	UGACACCAACAUUCUGGAC	GUCCAGAAUGUUGGUGUCA	Chmp	[476-494]
					467	UAUCUCACUCAGGAGAAGU	ACUUCUCCUGAGUGAGAUA	Chmp	[642-660]
468	AUGACCACCUUACUCAGCU	AGCUGAGUAAGGUGGUCAU	Chmp	[930-948]
					469	GAGAACUUUAAGGUCUUUG	CAAAGACCUUAAAGUUCUC	大鼠，Chmp	[888-906]
470	UUCUUUCUACCCUGCUGGG	CCCAGCAGGGUAGAAAGAA	Chmp	[1228-1246]
					471	AGUUAACCAGAUUGAGUGC	GCACUCAAUCUGGUUAACU	Chmp	[617-635]
472	CUUGUUGAGCUGUACCUCC	GGAGGUACAGCUCAACAAG	Chmp	[974-992]
					473	AUGGAAGAGCUGGUGGAUG	CAUCCACCAGCUCUUCCAU	Chmp	[507-525]
474	AAGAGUUUUGAAGCUGUGG	CCACAGCUUCAAAACUCUU	Chmp	[1015-1033]
					475	UGCCUCAUUUUUUUCCUUG	CAAGGAAAAAAAUGAGGCA	Chmp	[1073-1091]
476	ACUCAGCUACAACAGGAAC	GUUCCUGUUGUAGCUGAGU	大鼠，Ms，Chmp	[941-959]
					477	UUUUUCCUUGCAAAUGUAG	CUACAUUUGCAAGGAAAAA	Chmp	[1082-1100]
478	ACCAGGUCAAAAUAGUGCC	GGCACUAUUUUGACCUGGU	Chmp	[1295-1313]

479	UACCUCCCACAAGGAUUAC	GUAAUCCUUGUGGGAGGUA	Chmp	[986-1004]
					480	UACCAGAAUGAGAAUGAGG	CCUCAUUCUCAUUCUGGUA	Chmp	[219-237]
481	AGUGACACCAACAUUCUGG	CCAGAAUGUUGGUGUCACU	Chmp	[474-492]
					482	UCUCUUCCAGUUUGCUUUG	CAAAGCAAACUGGAAGAGA	Chmp	[1206-1224]
483	UUUUUCCCAUUGGAUGAGU	ACUCAUCCAAUGGGAAAAA		[438-456]
					484	UAGAGUAGAAGUCUCUUCC	GGAAGAGACUUCUACUCUA	Chmp	[1195-1213]
485	CUGGACCUCUACCUUAUUC	GAAUAAGGUAGAGGUCCAG	大鼠，Chmp	[387-405]
					486	GUUUUGAAGCUGUGGUUGC	GCAACCACAGCUUCAAAAC		[1019-1037]
487	ACUCAGGAGAAGUUAAUCC	GGAUUAACUUCUCCUGAGU	Chmp	[648-666]
					488	UUGUUGAGCUGUACCUCCC	GGGAGGUACAGCUCAACAA	Chmp	[975-993]
489	UUUUGAAGCUGUGGUUGCC	GGCAACCACAGCUUCAAAA		[1020-1038]
					490	UUGGAUCUCAAGAGCCCUG	CAGGGCUCUUGAGAUCCAA	Chmp	[1172-1190]
491	UAGCUUGAUGUUGGAUCUC	GAGAUCCAACAUCAAGCUA		[1162-1180]
					492	UACAACCUGAAUACCCUUU	AAAGGGUAUUCAGGUUGUA	Chmp	[1252-1270]
493	UAUUUAAAGGUACGCGCCG	CGGCGCGUACCUUUAAAUA		[7-25]
					494	CUCUUCAUCGUCAGCAAGC	GCUUGCUGACGAUGAAGAG	Rb，Chmp	[291-309]
495	GACCACCUUACUCAGCUAC	GUAGCUGAGUAAGGUGGUC	Chmp	[932-950]
					496	UUUGAAGCUGUGGUUGCCU	AGGCAACCACAGCUUCAAA		[1021-1039]
497	AAAACUACAGCCCAGGUCC	GGACCUGGGCUGUAGUUUU	Chmp	[801-819]
					498	AUCGUCAGCAAGCUGUGGU	ACCACAGCUUGCUGACGAU	Rb，Chmp	[297-315]
499	CUGUGCCUUGUUGAGCUGU	ACAGCUCAACAAGGCACAG	Chmp	[968-986]
					500	CUGCUUGGAACUGGAAUCC	GGAUUCCAGUUCCAAGCAG		[1333-1351]

表B5 ASPP1-蛋白磷酸酶1，调节(抑制剂)亚单元13B

No.	正义链siRNA	反义链siRNA	其他Sp	人-121114286：284-3556
					1	GGAAAAAAAUUCAGCUGAA	UUCAGCUGAAUUUUUUUCC		[1239-1257]
2	CGAUGAUGCCGAUGAUAUU	AAUAUCAUCGGCAUCAUCG	Ms	[282-300]
					3	CCAGGAACAAAAUUCAAAA	UUUUGAAUUUUGUUCCUGG		[1129-1147]

4	CAACGUGAAUGCUGCUGAU	AUCAGCAGCAUUCACGUUG		[3118-3136]
					5	GGAGAAAAACGUACUGAAA	UUUCAGUACGUUUUUCUCC		[614-632]
6	CGUGAAUGCUGCUGAUAGU	ACUAUCAGCAGCAUUCACG		[3121-3139]
					7	CGGGCAUCGAGAUUGGUAA	UUACCAAUCUCGAUGCCCG		[1602-1620]
8	CAGGAAAGCUGCAGCUAGA	UCUAGCUGCAGCUUUCCUG		[3628-3646]
					9	GGCUUUUUAUAUACCAAAA	UUUUGGUAUAUAAAAAGCC		[4635-4653]
10	AAAUGUACCUGGAGAAAAA	UUUUUCUCCAGGUACAUUU		[604-622]
					11	CAGGCUUUUUAUAUACCAA	UUGGUAUAUAAAAAGCCUG		[4633-4651]
12	CGGCAGAGGACAAUAACAA	UUGUUAUUGUCCUCUGCCG		[2730-2748]
					13	CGGCAAUCUGUCUGCUGAA	UUCAGCAGACAGAUUGCCG		[904-922]
14	CAAUUACUAUAAAUCCAAA	UUUGGAUUUAUAGUAAUUG		[3780-3798]
					15	CGAACUCAGAGAAAUGUAA	UUACAUUUCUCUGAGUUCG		[584-602]
16	CGUACAGGCUUUUUAUAUA	UAUAUAAAAAGCCUGUACG		[4629-4647]
					17	CAUAGUGUGGUGAAGAAAA	UUUUCUUCACCACACUAUG		[4836-4854]
18	GUGUAAAUGUGCACAAUAA	UUAUUGUGCACAUUUACAC		[4924-4942]
					19	CGUCUCUAUGGGAAAAAAA	UUUUUUUCCCAUAGAGACG		[1229-1247]
20	GGCUGAGAGUCCGGUUUAA	UUAAACCGGACUCUCAGCC		[2925-2943]
					21	CAGGAAGUACAGACUGCAA	UUGCAGUCUGUACUUCCUG		[959-977]
22	CUGUCGAGAUGUUGUAGAA	UUCUACAACAUCUCGACAG		[364-382]
					23	CAGCGUUUACAUUUUCUAA	UUAGAAAAUGUAAACGCUG	Ms	[743-761]
24	GCAGCAGAAGGAACUCUUA	UAAGAGUUCCUUCUGCUGC		[1153-1171]
					25	UGUGGUGAAGAAAAGUGAA	UUCACUUUUCUUCACCACA		[4841-4859]
26	CCAACUUAACCAGGAACAA	UUGUUCCUGGUUAAGUUGG		[1120-1138]
					27	GGGCAUCGAGAUUGGUAAA	UUUACCAAUCUCGAUGCCC		[1603-1621]
28	CCAUGUUCCAGGAAAAGAA	UUCUUUUCCUGGAACAUGG	大鼠	[939-957]
					29	AGGAGAACAAGCUGAAGAA	UUCUUCAGCUUGUUCUCCU	大鼠	[840-858]
30	GUCUAUUUCUGAAAAUGAA	UUCAUUUUCAGAAAUAGAC		[787-805]

31	GCAGCAGUCUAUUUCUGAA	UUCAGAAAUAGACUGCUGC		[781-799]
					32	CAAUCUGUCUGCUGAAAUA	UAUUUCAGCAGACAGAUUG		[907-925]
33	CAACCAUAAGCGACAUUGA	UCAAUGUCGCUUAUGGUUG		[3231-3249]
					34	CAGCAGAAGGAACUCUUAA	UUAAGAGUUCCUUCUGCUG		[1154-1172]
35	CACUGAGGUGUGAAUUGUA	UACAAUUCACACCUCAGUG		[4610-4628]
					36	GGGAGAGCCUCAGCAUAUA	UAUAUGCUGAGGCUCUCCC		[4236-4254]
37	CACGGAGGGAAGAAGUGAA	UUCACUUCUUCCCUCCGUG		[495-513]
					38	AGAAGGAACUCUUAAAUAA	UUAUUUAAGAGUUCCUUCU		[1158-1176]
39	AGCUGGGUGUGAUGAACAA	UUGUUCAUCACACCCAGCU		[3327-3345]
					40	GCUAGAAAAUGGUCUUAAU	AUUAAGACCAUUUUCUAGC		[3641-3659]
41	CGAUGAUAUUAACUGUUUU	AAAACAGUUAAUAUCAUCG		[291-309]
					42	AGGGCUAUGUGCCCAAAAA	UUUUUGGGCACAUAGCCCU	大鼠	[3486-3504]
43	AGCAGAAGGAACUCUUAAA	UUUAAGAGUUCCUUCUGCU		[1155-1173]
					44	CCGGCAGAGGACAAUAACA	UGUUAUUGUCCUCUGCCGG		[2729-2747]
45	GUACGAACAUCUUCAGAAA	UUUCUGAAGAUGUUCGUAC		[469-487]
					46	GGCUGUAUCCACGGAUCAA	UUGAUCCGUGGAUACAGCC		[3513-3531]
47	CUCAGAGAAAUGUAAUAAA	UUUAUUACAUUUCUCUGAG		[588-606]
					48	CAAGGAACAGCGUUUACAU	AUGUAAACGCUGUUCCUUG	大鼠，Ms	[736-754]
49	GCAACAGCAGCAGAUUGAA	UUCAAUCUGCUGCUGUUGC		[694-712]
					50	CCCAGGAGAACAAGCUGAA	UUCAGCUUGUUCUCCUGGG	大鼠	[837-855]
51	GAAUGCUGCUGAUAGUGAU	AUCACUAUCAGCAGCAUUC		[3124-3142]
					52	CAGCAAUUGGAAGAUUUAA	UUAAAUCUUCCAAUUGCUG		[1001-1019]
53	GCAAAAUCAUGAACGGCAA	UUGCCGUUCAUGAUUUUGC		[891-909]
					54	CUUAAAUAAGUCAGUUAAA	UUUAACUGACUUAUUUAAG	Ms	[2083-2101]
55	CUGUCUGCUGAAAUAGAAA	UUUCUAUUUCAGCAGACAG		[911-929]
					56	GGAGAACAAGCUGAAGAAA	UUUCUUCAGCUUGUUCUCC		[841-859]
57	CACCGAAUCGGACACUCAU	AUGAGUGUCCGAUUCGGUG		[3979-3997]

58	CCAUGAUGGACAAGCGAAU	AUUCGCUUGUCCAUCAUGG		[1194-1212]
					59	GGACAAGCGAAUCAGUGAA	UUCACUGAUUCGCUUGUCC		[1201-1219]
60	GAUCCAAAUCCGCUAAUGA	UCAUUAGCGGAUUUGGAUC		[1422-1440]
					61	GCGGCGGUGGAGUUAAAAA	UUUUUAACUCCACCGCCGC		[1073-1091]
62	CAGCGUCCACAAUGUGAAU	AUUCACAUUGUGGACGCUG		[3678-3696]
					63	CCAUUAAGAAGUCCCAUAA	UUAUGGGACUUCUUAAUGG		[3833-3851]
64	GUACAGACUGCAAUUUUAA	UUAAAAUUGCAGUCUGUAC		[965-983]
					65	CAACUUAACCAGGAACAAA	UUUGUUCCUGGUUAAGUUG		[1121-1139]
66	CCAACUUGAAGAAGCCCAA	UUGGGCUUCUUCAAGUUGG		[2886-2904]
					67	AGAACAAGCUGAAGAAAAU	AUUUUCUUCAGCUUGUUCU		[843-861]
68	CAAGUCGACUACAGCAAAA	UUUUGCUGUAGUCGACUUG		[878-896]
					69	AACCAGGAACAAAAUUCAA	UUGAAUUUUGUUCCUGGUU		[1127-1145]
70	GGGAAAUGAACGUCCCAUA	UAUGGGACGUUCAUUUCCC		[433-451]
					71	AACCAUAAGCGACAUUGAA	UUCAAUGUCGCUUAUGGUU		[3232-3250]
72	GGCGGUGGAGUUAAAAAGA	UCUUUUUAACUCCACCGCC		[1075-1093]
					73	GCCUGAACUUCCUUUUGGA	UCCAAAAGGAAGUUCAGGC		[3551-3569]
74	GAAAAUUCGUGCAAUGAGA	UCUCAUUGCACGAAUUUUC		[856-874]
					75	CGCGAUGAUGCCGAUGAUA	UAUCAUCGGCAUCAUCGCG	Ms	[280-298]
76	GAGCAACAAUGAACAGAUU	AAUCUGUUCAUUGUUGCUC	大鼠，Ms	[313-331]
					77	AACUGAGAACAGUGAACAA	UUGUUCACUGUUCUCAGUU		[541-559]
78	AGUACAGACUGCAAUUUUA	UAAAAUUGCAGUCUGUACU		[964-982]
					79	GAGAAAAACGUACUGAAAA	UUUUCAGUACGUUUUUCUC		[615-633]
80	CAGAGGACAAUAACAACAA	UUGUUGUUAUUGUCCUCUG		[2733-2751]
					81	UGUAAAUGUGCACAAUAAA	UUUAUUGUGCACAUUUACA		[4925-4943]
82	CCACAAUGUGAAUCCUACA	UGUAGGAUUCACAUUGUGG		[3684-3702]
					83	GGAAGAUCCAAAUCCGCUA	UAGCGGAUUUGGAUCUUCC		[1418-1436]
84	ACUACAGAUUCGUAACCAA	UUGGUUACGAAUCUGUAGU		[1105-1123]

85	GAAAGCUGCAGCUAGAAAA	UUUUCUAGCUGCAGCUUUC		[3631-3649]
					86	GCCGAUGUGGACAAUGGAA	UUCCAUUGUCCACAUCGGC		[2549-2567]
87	AACUUAACCAGGAACAAAA	UUUUGUUCCUGGUUAAGUU		[1122-1140]
					88	CCAAUUACUAUAAAUCCAA	UUGGAUUUAUAGUAAUUGG		[3779-3797]
89	CAACAGCAGCAGAUUGAAA	UUUCAAUCUGCUGCUGUUG		[695-713]
					90	GGAAAAGAAGCAGGAAGUA	UACUUCCUGCUUCUUUUCC		[949-967]
91	GAGUUGAAGCCCAGGAGAA	UUCUCCUGGGCUUCAACUC		[828-846]
					92	GCUGUAUCCACGGAUCAAA	UUUGAUCCGUGGAUACAGC		[3514-3532]
93	GGGACAUACCCAAGUCCUA	UAGGACUUGGGUAUGUCCC		[1670-1688]
					94	AGGCUUUUUAUAUACCAAA	UUUGGUAUAUAAAAAGCCU		[4634-4652]
95	AGCGGACCAACUUGAAGAA	UUCUUCAAGUUGGUCCGCU		[2880-2898]
					96	CGACAUUGAAACUGCUGCA	UGCAGCAGUUUCAAUGUCG		[3241-3259]
97	UGGAGAAAAACGUACUGAA	UUCAGUACGUUUUUCUCCA		[613-631]
					98	CUCUCAGUAUUGCCUCAAA	UUUGAGGCAAUACUGAGAG		[1389-1407]
99	CAAGAGCAACGAACUCAGA	UCUGAGUUCGUUGCUCUUG		[575-593]
					100	CAGAAAGUACUGAGAAAGA	UCUUUCUCAGUACUUUCUG		[2208-2226]
101	CCAGGAAAAGAAGCAGGAA	UUCCUGCUUCUUUUCCUGG	大鼠	[946-964]
					102	UGGGAAUCCACGUGUUGAA	UUCAACACGUGGAUUCCCA	Ms	[640-658]
103	AAGUGAACGCCCUUGUAGA	UCUACAAGGGCGUUCACUU		[4853-4871]
					104	AAAUGAAAAGCUUCAGAAA	UUUCUGAAGCUUUUCAUUU	Ms	[799-817]
105	GCUUAGUCAGCAAUUGGAA	UUCCAAUUGCUGACUAAGC		[994-1012]
					106	GAGCAACGAACUCAGAGAA	UUCUCUGAGUUCGUUGCUC		[578-596]
107	UGAACAGAUUUUAACAGAA	UUCUGUUAAAAUCUGUUCA	大鼠，Ms	[322-340]
					108	CAACAAUGAACAGAUUUUA	UAAAAUCUGUUCAUUGUUG	大鼠，Ms	[316-334]
109	GGAAAGCUGCAGCUAGAAA	UUUCUAGCUGCAGCUUUCC		[3630-3648]
					110	CAAUGAACAGAUUUUAACA	UGUUAAAAUCUGUUCAUUG	大鼠，Ms	[319-337]
111	GAGAAAUGUAAUAAAUGUA	UACAUUUAUUACAUUUCUC		[592-610]

112	CCUUAAAUAAGUCAGUUAA	UUAACUGACUUAUUUAAGG	Ms	[2082-2100]
					113	GCUGAAAUAGAAAGGUUCA	UGAACCUUUCUAUUUCAGC		[917-935]
114	CAGAAGGAACUCUUAAAUA	UAUUUAAGAGUUCCUUCUG		[1157-1175]
					115	GUGUGGUGAAGAAAAGUGA	UCACUUUUCUUCACCACAC		[4840-4858]
116	CAGCGUUCACCUCUGCAAA	UUUGCAGAGGUGAACGCUG		[3178-3196]
					117	CUGUUUUCUUGAGCAACAA	UUGUUGCUCAAGAAAACAG		[303-321]
118	GAGGUACUUUCGCCUCCAA	UUGGAGGCGAAAGUACCUC		[3747-3765]
					119	AAAGCUUCAGAAAUUGAAA	UUUCAAUUUCUGAAGCUUU		[805-823]
120	AACAAUGAACAGAUUUUAA	UUAAAAUCUGUUCAUUGUU	大鼠，Ms	[317-335]
					121	CGAACAAGCGGACCAACUU	AAGUUGGUCCGCUUGUUCG		[2874-2892]
122	CAGACCCAAGAGCAACGAA	UUCGUUGCUCUUGGGUCUG		[569-587]
					123	GACUGUACCAAGAACUACA	UGUAGUUCUUGGUACAGUC		[1092-1110]
124	AGAUUUAAAGAAAGGAAAA	UUUUCCUUUCUUUAAAUCU	Ms	[1012-1030]
					125	GAGAACAAGCUGAAGAAAA	UUUUCUUCAGCUUGUUCUC		[842-860]
126	UAACCAACUUAACCAGGAA	UUCCUGGUUAAGUUGGUUA		[1117-1135]
					127	GAAGAUUUAAAGAAAGGAA	UUCCUUUCUUUAAAUCUUC	大鼠，Ms	[1010-1028]
128	ACGUCUCUAUGGGAAAAAA	UUUUUUCCCAUAGAGACGU		[1228-1246]
					129	ACGGAGGGAAGAAGUGAAA	UUUCACUUCUUCCCUCCGU		[496-514]
130	CCUGGAAAGGAGGAAGGAA	UUCCUUCCUCCUUUCCAGG		[1717-1735]
					131	UCUCCAGUUUGCCCAUUAA	UUAAUGGGCAAACUGGAGA		[3722-3740]
132	UAAAGAAAGGAAAACUGAA	UUCAGUUUUCCUUUCUUUA	Ms	[1017-1035]
					133	GGGAAGAAGUGAAAUUUUU	AAAAAUUUCACUUCUUCCC		[501-519]
134	CAAGAACUACAGAUUCGUA	UACGAAUCUGUAGUUCUUG		[1100-1118]
					135	GUACGUACAGGCUUUUUAU	AUAAAAAGCCUGUACGUAC		[4626-4644]
136	AGCAAUUGGAAGAUUUAAA	UUUAAAUCUUCCAAUUGCU		[1002-1020]
					137	GCAGAAGGAACUCUUAAAU	AUUUAAGAGUUCCUUCUGC		[1156-1174]
138	CCUAAAGGCUGAUUGUGCA	UGCACAAUCAGCCUUUAGG		[4152-4170]

139	GCAGCAGAUUGAAAAUCAG	CUGAUUUUCAAUCUGCUGC		[700-718]
					140	CGGUGGAGUUAAAAAGACU	AGUCUUUUUAACUCCACCG		[1077-1095]
141	CAAUGUGAAUCCUACAGUU	AACUGUAGGAUUCACAUUG		[3687-3705]
					142	UGAUCAGCUUAGUCAGCAA	UUGCUGACUAAGCUGAUCA	Ms	[988-1006]
143	GGACAAUGGAAACACCAAU	AUUGGUGUUUCCAUUGUCC	大鼠	[2557-2575]
					144	AGCCGGCAGAGGACAAUAA	UUAUUGUCCUCUGCCGGCU		[2727-2745]
145	AUUGGAAGAUUUAAAGAAA	UUUCUUUAAAUCUUCCAAU		[1006-1024]
					146	GCUGGGUGUGAUGAACAAA	UUUGUUCAUCACACCCAGC		[3328-3346]
147	CCUAUAACACCGGAAACAA	UUGUUUCCGGUGUUAUAGG		[344-362]
					148	GAAAGAGCCUGAGCAGGAU	AUCCUGCUCAGGCUCUUUC		[2221-2239]
149	UCUGUCUGCUGAAAUAGAA	UUCUAUUUCAGCAGACAGA		[910-928]
					150	AGAAAAACGUACUGAAAAU	AUUUUCAGUACGUUUUUCU		[616-634]
151	CACCAAAGGAGCCUCUGUA	UACAGAGGCUCCUUUGGUG		[4039-4057]
					152	ACAAGCGGACCAACUUGAA	UUCAAGUUGGUCCGCUUGU		[2877-2895]
153	CAGUGAAGACAGAAGCUCU	AGAGCUUCUGUCUUCACUG		[3867-3885]
					154	CUCUAUUUUUCAUGUAUGA	UCAUACAUGAAAAAUAGAG		[4735-4753]
155	GGACAAGUCGACUACAGCA	UGCUGUAGUCGACUUGUCC		[875-893]
					156	GAUCAUCUAUGAGGUGGAA	UUCCACCUCAUAGAUGAUC	大鼠	[3001-3019]
157	GCUCAUGGAAGAUCCAAAU	AUUUGGAUCUUCCAUGAGC		[1412-1430]
					158	UGUAGAAUUUUGCAAGGAA	UUCCUUGCAAAAUUCUACA		[376-394]
159	ACAGCGUCCACAAUGUGAA	UUCACAUUGUGGACGCUGU		[3677-3695]
					160	CUCUCAGAGCUCCAAGAUA	UAUCUUGGAGCUCUGAGAG		[665-683]
161	CGUGAACGUCUCUAUGGGA	UCCCAUAGAGACGUUCACG		[1223-1241]
					162	AUGGGUUCCAGUCUUACAA	UUGUAAGACUGGAACCCAU		[1035-1053]
163	UCGACAAGCUCCCUGGAAA	UUUCCAGGGAGCUUGUCGA		[1706-1724]
					164	CAGACUCACUGAUGCAGCA	UGCUGCAUCAGUGAGUCUG		[4785-4803]
165	CCCAGACAGUGAAUUCAAG	CUUGAAUUCACUGUCUGGG		[1995-2013]

166	CAGUGCUCCCAGUUUCUAU	AUAGAAACUGGGAGCACUG		[3293-3311]
					167	CCCAACUGAGAACAGUGAA	UUCACUGUUCUCAGUUGGG		[538-556]
168	GAUGGACAAGCGAAUCAGU	ACUGAUUCGCUUGUCCAUC		[1198-1216]
					169	AACAGAAGUUCCUAUAACA	UGUUAUAGGAACUUCUGUU	大鼠，Ms	[334-352]
170	UGCAGAGGAUCAUCUAUGA	UCAUAGAUGAUCCUCUGCA	大鼠，Ms	[2994-3012]
					171	CAGCAGUCUAUUUCUGAAA	UUUCAGAAAUAGACUGCUG		[782-800]
172	AAAAGUGAACGCCCUUGUA	UACAAGGGCGUUCACUUUU		[4851-4869]
					173	GGUGUGAAUUGUACGUACA	UGUACGUACAAUUCACACC		[4616-4634]
174	UACAUAGUGUGGUGAAGAA	UUCUUCACCACACUAUGUA		[4834-4852]
					175	GAACGUCUCUAUGGGAAAA	UUUUCCCAUAGAGACGUUC		[1226-1244]
176	CAUUUUUGCCUCAACCAUA	UAUGGUUGAGGCAAAAAUG		[3220-3238]
					177	UGCUCAUGGAAGAUCCAAA	UUUGGAUCUUCCAUGAGCA		[1411-1429]
178	CCGAUGUGGACAAUGGAAA	UUUCCAUUGUCCACAUCGG		[2550-2568]
					179	GCAGGAAGUACAGACUGCA	UGCAGUCUGUACUUCCUGC		[958-976]
180	AGCUAUGGGACAUACCCAA	UUGGGUAUGUCCCAUAGCU		[1664-1682]
					181	AGGAAAGCUGCAGCUAGAA	UUCUAGCUGCAGCUUUCCU		[3629-3647]
182	GGAACAAAAUUCAAAACUU	AAGUUUUGAAUUUUGUUCC		[1132-1150]
					183	UCGUGAAGUUCCUGCUGGA	UCCAGCAGGAACUUCACGA		[3090-3108]
184	GGACACUCAUCCUUUCUCA	UGAGAAAGGAUGAGUGUCC		[3988-4006]
					185	CGAACACUCGCCUGAACUU	AAGUUCAGGCGAGUGUUCG		[3542-3560]
186	CAGACAGCGUCCACAAUGU	ACAUUGUGGACGCUGUCUG		[3674-3692]
					187	GUCUCUAUGGGAAAAAAAU	AUUUUUUUCCCAUAGAGAC		[1230-1248]
188	GGAAGUACAGACUGCAAUU	AAUUGCAGUCUGUACUUCC		[961-979]
					189	AAAAGAAGCAGGAAGUACA	UGUACUUCCUGCUUCUUUU		[951-969]
190	GUACCUGGAGAAAAACGUA	UACGUUUUUCUCCAGGUAC		[608-626]
					191	AAUAAAUACCCACUUUCAA	UUGAAAGUGGGUAUUUAUU		[3797-3815]
192	AGUUAAAAAGACUGUACCA	UGGUACAGUCUUUUUAACU		[1083-1101]

193	ACCAUAAGCGACAUUGAAA	UUUCAAUGUCGCUUAUGGU		[3233-3251]
					194	CUGUUCCAGUUCACCUAAA	UUUAGGUGAACUGGAACAG		[4139-4157]
195	GUAUGGUAAGCCCGUUUUA	UAAAACGGGCUUACCAUAC		[2107-2125]
					196	ACUUAACCAGGAACAAAAU	AUUUUGUUCCUGGUUAAGU		[1123-1141]
197	GGAACAGCGUUUACAUUUU	AAAAUGUAAACGCUGUUCC	Ms	[739-757]
					198	AAGACUGUACCAAGAACUA	UAGUUCUUGGUACAGUCUU		[1090-1108]
199	GAGGGCUAUGUGCCCAAAA	UUUUGGGCACAUAGCCCUC	大鼠	[3485-3503]
					200	AUUUUUGCCUCAACCAUAA	UUAUGGUUGAGGCAAAAAU		[3221-3239]
201	CCCUAAGACCAAGUGACAA	UUGUCACUUGGUCUUAGGG		[4215-4233]
					202	GGAUCAUCUAUGAGGUGGA	UCCACCUCAUAGAUGAUCC	大鼠，Ms	[3000-3018]
203	GCUGCUCAUGGAAGAUCCA	UGGAUCUUCCAUGAGCAGC		[1409-1427]
					204	GGCCCUUAGGCUCUAUUUU	AAAAUAGAGCCUAAGGGCC		[4725-4743]
205	UAACCAGGAACAAAAUUCA	UGAAUUUUGUUCCUGGUUA		[1126-1144]
					206	UGGACAAUGGAAACACCAA	UUGGUGUUUCCAUUGUCCA	大鼠	[2556-2574]
207	GAAGGAACUCUUAAAUAAG	CUUAUUUAAGAGUUCCUUC		[1159-1177]
					208	UGCUGCUGAUAGUGAUGGA	UCCAUCACUAUCAGCAGCA		[3127-3145]
209	AGAUUCGUAACCAACUUAA	UUAAGUUGGUUACGAAUCU		[1110-1128]
					210	GGGUGUGAUGAACAAAGGU	ACCUUUGUUCAUCACACCC		[3331-3349]
211	AUCCAAAUCCGCUAAUGAU	AUCAUUAGCGGAUUUGGAU		[1423-1441]
					212	GGAGGGAAGAAGUGAAAUU	AAUUUCACUUCUUCCCUCC		[498-516]
213	GAAGAUCCAAAUCCGCUAA	UUAGCGGAUUUGGAUCUUC		[1419-1437]
					214	ACUACAGCAAAAUCAUGAA	UUCAUGAUUUUGCUGUAGU	大鼠	[885-903]
215	CGGCGGUGGAGUUAAAAAG	CUUUUUAACUCCACCGCCG		[1074-1092]
					216	CCAUUAACUGGGAGAGGUA	UACCUCUCCCAGUUAAUGG		[3734-3752]
217	AUUGAAAGAACGAGUUGAA	UUCAACUCGUUCUUUCAAU		[817-835]
					218	GACAGAAGCUCUUACUGAC	GUCAGUAAGAGCUUCUGUC		[3874-3892]
219	GGCAACAGCAGCAGAUUGA	UCAAUCUGCUGCUGUUGCC		[693-711]

220	CAAAACUUCAGCAGCAGAA	UUCUGCUGCUGAAGUUUUG		[1143-1161]
					221	UCAGCAAUUGGAAGAUUUA	UAAAUCUUCCAAUUGCUGA		[1000-1018]
222	CGAUGUGGACAAUGGAAAC	GUUUCCAUUGUCCACAUCG		[2551-2569]
					223	CAGGCUCCUCACAACAGAU	AUCUGUUGUGAGGAGCCUG		[1818-1836]
224	ACAUUAAAACAGAAUUCUA	UAGAAUUCUGUUUUAAUGU		[1454-1472]
					225	ACCCGAACUAUGUUGGAAA	UUUCCAACAUAGUUCGGGU		[4682-4700]
226	CGGAGGGAAGAAGUGAAAU	AUUUCACUUCUUCCCUCCG		[497-515]
					227	UCAGCUGAACCGUGUGAAU	AUUCACACGGUUCAGCUGA		[1249-1267]
228	ACCAGGAACAAAAUUCAAA	UUUGAAUUUUGUUCCUGGU		[1128-1146]
					229	CCAUUCAAAGCUACCCGAA	UUCGGGUAGCUUUGAAUGG		[4670-4688]
230	GCCUCAACCAUAAGCGACA	UGUCGCUUAUGGUUGAGGC		[3227-3245]
					231	UAGCAGACAGCGUCCACAA	UUGUGGACGCUGUCUGCUA		[3671-3689]
232	GUUUUACCUUCGGGUUCAA	UUGAACCCGAAGGUAAAAC		[2120-2138]
					233	CAGUGAACUGCGUGAACGU	ACGUUCACGCAGUUCACUG		[1213-1231]
234	ACAAGUCGACUACAGCAAA	UUUGCUGUAGUCGACUUGU		[877-895]
					235	GACCCAAGAGCAACGAACU	AGUUCGUUGCUCUUGGGUC		[571-589]
236	GCGAUGAUGCCGAUGAUAU	AUAUCAUCGGCAUCAUCGC	Ms	[281-299]
					237	UACCAAAAGUAUUUUUUGA	UCAAAAAAUACUUUUGGUA		[4646-4664]
238	AGACAGAAGCUCUUACUGA	UCAGUAAGAGCUUCUGUCU		[3873-3891]
					239	GGUGCAGAGGAUCAUCUAU	AUAGAUGAUCCUCUGCACC		[2992-3010]
240	AGGAGAUGGAGGAAGGCUA	UAGCCUUCCUCCAUCUCCU		[3270-3288]
					241	CAAUGAGAGGACAAGUCGA	UCGACUUGUCCUCUCAUUG		[867-885]
242	AGAGAAAUGUAAUAAAUGU	ACAUUUAUUACAUUUCUCU		[591-609]
					243	CGAGAUGUUGUAGAAUUUU	AAAAUUCUACAACAUCUCG		[368-386]
244	AACUCAGAGAAAUGUAAUA	UAUUACAUUUCUCUGAGUU		[586-604]
					245	AGCGUUUACAUUUUCUAAA	UUUAGAAAAUGUAAACGCU	Ms	[744-762]
246	UCAGAGAAAUGUAAUAAAU	AUUUAUUACAUUUCUCUGA		[589-607]

247	UGGUGCAGAGGAUCAUCUA	UAGAUGAUCCUCUGCACCA		[2991-3009]
					248	AGAGCAACGAACUCAGAGA	UCUCUGAGUUCGUUGCUCU		[577-595]
249	AGGAGCCUCUGUAUGGAAA	UUUCCAUACAGAGGCUCCU		[4045-4063]
					250	CCGUCAGCAGCAGUCUAUU	AAUAGACUGCUGCUGACGG		[775-793]
251	CAAGUUCCAUAUACUCCAU	AUGGAGUAUAUGGAACUUG		[2010-2028]
					252	ACUAGACCAUUCAAAGCUA	UAGCUUUGAAUGGUCUAGU		[4664-4682]
253	GAUGUUGUAGAAUUUUGCA	UGCAAAAUUCUACAACAUC		[371-389]
					254	CACUGUAGCCCAUCACCUU	AAGGUGAUGGGCUACAGUG		[4802-4820]
255	GAUGAUGCCGAUGAUAUUA	UAAUAUCAUCGGCAUCAUC	Ms	[283-301]
					256	GCAACGAACUCAGAGAAAU	AUUUCUCUGAGUUCGUUGC		[580-598]
257	UGCGCUGCCUCUUGUAACA	UGUUACAAGAGGCAGCGCA		[3161-3179]
					258	CCACACCACCUAAGAAUUA	UAAUUCUUAGGUGGUGUGG		[2043-2061]
259	GGCUCUAUUUUUCAUGUAU	AUACAUGAAAAAUAGAGCC		[4733-4751]
					260	UGAGCAACAAUGAACAGAU	AUCUGUUCAUUGUUGCUCA	大鼠，Ms	[312-330]
261	AAUGGGUUCCAGUCUUACA	UGUAAGACUGGAACCCAUU		[1034-1052]
					262	GCUCUUCCGUGAAACCAGU	ACUGGUUUCACGGAAGAGC		[1473-1491]
263	AACUCUUAAAUAAGCGCAA	UUGCGCUUAUUUAAGAGUU		[1164-1182]
					264	GCAGUCUAUUUCUGAAAAU	AUUUUCAGAAAUAGACUGC		[784-802]
265	UGUGCUGUUUUCCAGGAAA	UUUCCUGGAAAACAGCACA		[3616-3634]
					266	AAAAGCUUCAGAAAUUGAA	UUCAAUUUCUGAAGCUUUU		[804-822]
267	CAAUUUUAAGGGUUGAUCA	UGAUCAACCCUUAAAAUUG		[975-993]
					268	GCUGCAGCUAGAAAAUGGU	ACCAUUUUCUAGCUGCAGC		[3635-3653]
269	CGCUAAUGAUGGAAACUGG	CCAGUUUCCAUCAUUAGCG		[1432-1450]
					270	AGUGAAGACAGAAGCUCUU	AAGAGCUUCUGUCUUCACU		[3868-3886]
271	AGUGCUCCCAGUUUCUAUA	UAUAGAAACUGGGAGCACU		[3294-3312]
					272	UUCAGAAAGUACUGAGAAA	UUUCUCAGUACUUUCUGAA		[2206-2224]
273	GCUGGAUUUUGGUGUCAAC	GUUGACACCAAAAUCCAGC		[3103-3121]

274	UUUUGACUAGACCAUUCAA	UUGAAUGGUCUAGUCAAAA		[4659-4677]
					275	AGCAGUCUAUUUCUGAAAA	UUUUCAGAAAUAGACUGCU		[783-801]
276	UCGAGAUGUUGUAGAAUUU	AAAUUCUACAACAUCUCGA		[367-385]
					277	UCGUGCAAUGAGAGGACAA	UUGUCCUCUCAUUGCACGA		[862-880]
278	CCUUAGGCUCUAUUUUUCA	UGAAAAAUAGAGCCUAAGG		[4728-4746]
					279	CCUGUUCCAGUUCACCUAA	UUAGGUGAACUGGAACAGG		[4138-4156]
280	GAGGAAGGCUACAUCCAGU	ACUGGAUGUAGCCUUCCUC		[3278-3296]
					281	ACAGCAGCAGAUUGAAAAU	AUUUUCAAUCUGCUGCUGU		[697-715]
282	CUACCCGAACUAUGUUGGA	UCCAACAUAGUUCGGGUAG		[4680-4698]
					283	CCUUCAGAAAGUACUGAGA	UCUCAGUACUUUCUGAAGG		[2204-2222]
284	CAGUGAAUUCAAGUUCCAU	AUGGAACUUGAAUUCACUG		[2001-2019]
					285	UCGACUACAGCAAAAUCAU	AUGAUUUUGCUGUAGUCGA		[882-900]
286	AGCAACGAACUCAGAGAAA	UUUCUCUGAGUUCGUUGCU		[579-597]
					287	GGCAAUCUGUCUGCUGAAA	UUUCAGCAGACAGAUUGCC		[905-923]
288	CCAUUUUUGCCUCAACCAU	AUGGUUGAGGCAAAAAUGG		[3219-3237]
					289	AAGAUUUAAAGAAAGGAAA	UUUCCUUUCUUUAAAUCUU	大鼠，Ms	[1011-1029]
290	GAAGAAAAGUGAACGCCCU	AGGGCGUUCACUUUUCUUC		[4847-4865]
					291	CUGAAAAAGCGCAGCUCCA	UGGAGCUGCGCUUUUUCAG		[2396-2414]
292	GAACUCAGAGAAAUGUAAU	AUUACAUUUCUCUGAGUUC		[585-603]
					293	UGAAGAAGCCCAACUCGGA	UCCGAGUUGGGCUUCUUCA		[2892-2910]
294	UGAGAACAGUGAACAAGGU	ACCUUGUUCACUGUUCUCA		[544-562]
					295	GCCCUUAGGCUCUAUUUUU	AAAAAUAGAGCCUAAGGGC		[4726-4744]
296	UGAUCAUAUGAUGUACGAA	UUCGUACAUCAUAUGAUCA		[457-475]
					297	UGGACAAGCGAAUCAGUGA	UCACUGAUUCGCUUGUCCA		[1200-1218]
298	AACAGCAGCAGAUUGAAAA	UUUUCAAUCUGCUGCUGUU		[696-714]
					299	GGGAAAAAAAUUCAGCUGA	UCAGCUGAAUUUUUUUCCC		[1238-1256]
300	GGCAGAGGACAAUAACAAC	GUUGUUAUUGUCCUCUGCC		[2731-2749]

301	GAAUCAGUGAACUGCGUGA	UCACGCAGUUCACUGAUUC		[1209-1227]
					302	CUCAAAUGCUGCUCAUGGA	UCCAUGAGCAGCAUUUGAG		[1402-1420]
303	ACAGUGAAUUCAAGUUCCA	UGGAACUUGAAUUCACUGU		[2000-2018]
					304	AAAGCUGCAGCUAGAAAAU	AUUUUCUAGCUGCAGCUUU		[3632-3650]
305	CAAUUGGAAGAUUUAAAGA	UCUUUAAAUCUUCCAAUUG		[1004-1022]
					306	CGUCCACAAUGUGAAUCCU	AGGAUUCACAUUGUGGACG		[3681-3699]
307	CUCCAUGUACCUCCAGCAA	UUGCUGGAGGUACAUGGAG	大鼠，Ms	[2023-2041]
					308	CAGGAGAACAAGCUGAAGA	UCUUCAGCUUGUUCUCCUG	大鼠	[839-857]
309	UGGGUUCCAGUCUUACAAU	AUUGUAAGACUGGAACCCA		[1036-1054]
					310	CAGUUCACCUAAAGGCUGA	UCAGCCUUUAGGUGAACUG		[4145-4163]
311	AAGCGACAUUGAAACUGCU	AGCAGUUUCAAUGUCGCUU		[3238-3256]
					312	CCAGACAGUGAAUUCAAGU	ACUUGAAUUCACUGUCUGG		[1996-2014]
313	CUAUUUCUGAAAAUGAAAA	UUUUCAUUUUCAGAAAUAG		[789-807]
					314	GAAGAAAAUUCGUGCAAUG	CAUUGCACGAAUUUUCUUC		[853-871]
315	GUUCCAUAUACUCCAUGUA	UACAUGGAGUAUAUGGAAC		[2013-2031]
					316	GCUUCAGAAAUUGAAAGAA	UUCUUUCAAUUUCUGAAGC		[808-826]
317	ACAGGCUUUUUAUAUACCA	UGGUAUAUAAAAAGCCUGU		[4632-4650]
					318	ACAUAGUGUGGUGAAGAAA	UUUCUUCACCACACUAUGU		[4835-4853]
319	AGCAGACAGCGUCCACAAU	AUUGUGGACGCUGUCUGCU		[3672-3690]
					320	UAAAAAGACUGUACCAAGA	UCUUGGUACAGUCUUUUUA		[1086-1104]
321	ACUUCAGCAGCAGAAGGAA	UUCCUUCUGCUGCUGAAGU		[1147-1165]
					322	AGCGGCGGUGGAGUUAAAA	UUUUAACUCCACCGCCGCU		[1072-1090]
323	GCCUUAAAUAAGUCAGUUA	UAACUGACUUAUUUAAGGC		[2081-2099]
					324	CAAGCUGAAGAAAAUUCGU	ACGAAUUUUCUUCAGCUUG		[847-865]
325	AAGGAGCCUCUGUAUGGAA	UUCCAUACAGAGGCUCCUU		[4044-4062]
					326	UUUCUUGAGCAACAAUGAA	UUCAUUGUUGCUCAAGAAA		[307-325]
327	GGAAGAUUUAAAGAAAGGA	UCCUUUCUUUAAAUCUUCC		[1009-1027]

328	GGAGCACUGACUGUACAUA	UAUGUACAGUCAGUGCUCC		[4821-4839]
					329	CGGAAACAACCUGUCGAGA	UCUCGACAGGUUGUUUCCG		[354-372]
330	AAAAAGACUGUACCAAGAA	UUCUUGGUACAGUCUUUUU		[1087-1105]
					331	UGUAAUAAAUGUACCUGGA	UCCAGGUACAUUUAUUACA		[598-616]
332	CUGUACAUAGUGUGGUGAA	UUCACCACACUAUGUACAG		[4831-4849]
					333	AAAAGCUGGGUGUGAUGAA	UUCAUCACACCCAGCUUUU		[3324-3342]
334	CAGAUUCGUAACCAACUUA	UAAGUUGGUUACGAAUCUG		[1109-1127]
					335	GACAGCGUCCACAAUGUGA	UCACAUUGUGGACGCUGUC		[3676-3694]
336	CCAGUGCUCCCAGUUUCUA	UAGAAACUGGGAGCACUGG		[3292-3310]
					337	CAUCGAGAUUGGUAAAGUG	CACUUUACCAAUCUCGAUG		[1606-1624]
338	CAUUUAGCUGAAGUGUGGA	UCCACACUUCAGCUAAAUG		[413-431]
					339	GUGAAGACAGAAGCUCUUA	UAAGAGCUUCUGUCUUCAC		[3869-3887]
340	GUUAAAGCAGUGUAUGGUA	UACCAUACACUGCUUUAAC	大鼠	[2096-2114]
					341	CCACUUAAGAGAUUAUUGU	ACAAUAAUCUCUUAAGUGG		[3600-3618]
342	ACGAACUCAGAGAAAUGUA	UACAUUUCUCUGAGUUCGU		[583-601]
					343	AGAGGACAAUAACAACAAC	GUUGUUGUUAUUGUCCUCU		[2734-2752]
344	GCGCCUUAAAUAAGUCAGU	ACUGACUUAUUUAAGGCGC		[2079-2097]
					345	AGCUUAGUCAGCAAUUGGA	UCCAAUUGCUGACUAAGCU		[993-1011]
346	GAAGACAGAAGCUCUUACU	AGUAAGAGCUUCUGUCUUC		[3871-3889]
					347	GCAGAGGACAAUAACAACA	UGUUGUUAUUGUCCUCUGC		[2732-2750]
348	UCUAUUUCUGAAAAUGAAA	UUUCAUUUUCAGAAAUAGA		[788-806]
					349	CAACGAACUCAGAGAAAUG	CAUUUCUCUGAGUUCGUUG		[581-599]
350	UGCCGAUGAUAUUAACUGU	ACAGUUAAUAUCAUCGGCA		[288-306]
					351	CAUGGAAGAUCCAAAUCCG	CGGAUUUGGAUCUUCCAUG		[1415-1433]
352	UGAUGCCGAUGAUAUUAAC	GUUAAUAUCAUCGGCAUCA	Ms	[285-303]
					353	CCCUGCAAGCUCAAAUUCA	UGAAUUUGAGCUUGCAGGG		[4306-4324]
354	CCAAGUGACAACUGGGAGA	UCUCCCAGUUGUCACUUGG		[4223-4241]

355	GUCAGUUAAAGCAGUGUAU	AUACACUGCUUUAACUGAC	大鼠	[2092-2110]
					356	CUACCAGAGUGAUGCAGAC	GUCUGCAUCACUCUGGUAG		[2335-2353]
357	AAAGCUACCCGAACUAUGU	ACAUAGUUCGGGUAGCUUU		[4676-4694]
					358	CAAAUCCGCUAAUGAUGGA	UCCAUCAUUAGCGGAUUUG		[1426-1444]
359	UCUCAGAGCUCCAAGAUAU	AUAUCUUGGAGCUCUGAGA		[666-684]
					360	UGAACGUCUCUAUGGGAAA	UUUCCCAUAGAGACGUUCA		[1225-1243]
361	AUAAAUACCCACUUUCAAA	UUUGAAAGUGGGUAUUUAU		[3798-3816]
					362	CCAAGAGCAACGAACUCAG	CUGAGUUCGUUGCUCUUGG		[574-592]
363	CGCUUCACUGAGGUGUGAA	UUCACACCUCAGUGAAGCG		[4605-4623]
					364	CCAAGGAACAGCGUUUACA	UGUAAACGCUGUUCCUUGG	大鼠，Ms	[735-753]
365	CCUGCAAGCUCAAAUUCAG	CUGAAUUUGAGCUUGCAGG		[4307-4325]
					366	UUUUCUUGAGCAACAAUGA	UCAUUGUUGCUCAAGAAAA		[306-324]
367	CCUUUGAUCAUAUGAUGUA	UACAUCAUAUGAUCAAAGG		[453-471]
					368	UGCUGUACCAGCGCUUCAA	UUGAAGCGCUGGUACAGCA		[2457-2475]
369	GGACAAUAACAACAACGUG	CACGUUGUUGUUAUUGUCC	大鼠	[2737-2755]
					370	GAAAAUGAAAAGCUUCAGA	UCUGAAGCUUUUCAUUUUC	Ms	[797-815]
371	CAACAGAUUCAGCAGAGGA	UCCUCUGCUGAAUCUGUUG		[1829-1847]
					372	GACAAGUCGACUACAGCAA	UUGCUGUAGUCGACUUGUC		[876-894]
373	CACAGCGCCUUAAAUAAGU	ACUUAUUUAAGGCGCUGUG		[2075-2093]
					374	GACCAAGUGACAACUGGGA	UCCCAGUUGUCACUUGGUC		[4221-4239]
375	GCUGAAGAAAAUUCGUGCA	UGCACGAAUUUUCUUCAGC		[850-868]
					376	GUUCCUAUAACACCGGAAA	UUUCCGGUGUUAUAGGAAC		[341-359]
377	GGGCUAUGUGCCCAAAAAC	GUUUUUGGGCACAUAGCCC	大鼠	[3487-3505]
					378	AGGGAAGAAGUGAAAUUUU	AAAAUUUCACUUCUUCCCU		[500-518]
379	ACAGCGUUUACAUUUUCUA	UAGAAAAUGUAAACGCUGU	Ms	[742-760]
					380	GGGUUGAUCAGCUUAGUCA	UGACUAAGCUGAUCAACCC		[984-1002]
381	AAAGGAGCCUCUGUAUGGA	UCCAUACAGAGGCUCCUUU		[4043-4061]

382	AAAUAAAUACCCACUUUCA	UGAAAGUGGGUAUUUAUUU		[3796-3814]
					383	GGUUGAUCAGCUUAGUCAG	CUGACUAAGCUGAUCAACC		[985-1003]
384	CCAUACCCUUUGAUCAUAU	AUAUGAUCAAAGGGUAUGG		[447-465]
					385	AGAGGAUCAUCUAUGAGGU	ACCUCAUAGAUGAUCCUCU	大鼠，Ms	[2997-3015]
386	GAUUCGUAACCAACUUAAC	GUUAAGUUGGUUACGAAUC		[1111-1129]
					387	AGUCUAUUUCUGAAAAUGA	UCAUUUUCAGAAAUAGACU		[786-804]
388	GUACCAAGAACUACAGAUU	AAUCUGUAGUUCUUGGUAC		[1096-1114]
					389	CAAAAGUAUUUUUUGACUA	UAGUCAAAAAAUACUUUUG		[4649-4667]
390	CGUCAGCAGCAGUCUAUUU	AAAUAGACUGCUGCUGACG		[776-794]
					391	CUCUGGAAGGAGAGUUCGA	UCGAACUCUCCUUCCAGAG		[2970-2988]
392	AAUUGGAAGAUUUAAAGAA	UUCUUUAAAUCUUCCAAUU		[1005-1023]
					393	GUUAAAAAGACUGUACCAA	UUGGUACAGUCUUUUUAAC		[1084-1102]
394	CUGCUGAAAUAGAAAGGUU	AACCUUUCUAUUUCAGCAG		[915-933]
					395	AACCUGUCGAGAUGUUGUA	UACAACAUCUCGACAGGUU		[361-379]
396	GUAUUUUUUGACUAGACCA	UGGUCUAGUCAAAAAAUAC		[4654-4672]
					397	CUUCAGAAAGUACUGAGAA	UUCUCAGUACUUUCUGAAG		[2205-2223]
398	AAAUGCUGCUCAUGGAAGA	UCUUCCAUGAGCAGCAUUU		[1405-1423]
					399	GCUUCACUGAGGUGUGAAU	AUUCACACCUCAGUGAAGC		[4606-4624]
400	AUUUUGGUGUCAACGUGAA	UUCACGUUGACACCAAAAU		[3108-3126]
					401	UGGAGUUAAAAAGACUGUA	UACAGUCUUUUUAACUCCA		[1080-1098]
402	GCUACCAGAGUGAUGCAGA	UCUGCAUCACUCUGGUAGC		[2334-2352]
					403	GAAAAGCUUCAGAAAUUGA	UCAAUUUCUGAAGCUUUUC		[803-821]
404	GUAACCAACUUAACCAGGA	UCCUGGUUAAGUUGGUUAC		[1116-1134]
					405	CUGAGAAAGAGCCUGAGCA	UGCUCAGGCUCUUUCUCAG		[2217-2235]
406	CUGUACCAAGAACUACAGA	UCUGUAGUUCUUGGUACAG		[1094-1112]
					407	AGAAAAUGGUCUUAAUGGU	ACCAUUAAGACCAUUUUCU		[3644-3662]
408	CUCUUAAAUAAGCGCAACA	UGUUGCGCUUAUUUAAGAG		[1166-1184]

409	UCCAGAAGCUGCUGUACCA	UGGUACAGCAGCUUCUGGA		[2448-2466]
					410	UGAAUGGGUUCCAGUCUUA	UAAGACUGGAACCCAUUCA		[1032-1050]
411	CUUUUUAUAUACCAAAAGU	ACUUUUGGUAUAUAAAAAG		[4637-4655]
					412	CCAGGAGAACAAGCUGAAG	CUUCAGCUUGUUCUCCUGG	大鼠	[838-856]
413	UGGAGGAAGGCUACAUCCA	UGGAUGUAGCCUUCCUCCA		[3276-3294]
					414	AAGCCUGAACUCCCACUGA	UCAGUGGGAGUUCAGGCUU		[1913-1931]
415	GAACAAGCUGAAGAAAAUU	AAUUUUCUUCAGCUUGUUC		[844-862]
					416	GUACUUUCGCCUCCAAGGA	UCCUUGGAGGCGAAAGUAC		[3750-3768]
417	AAGGGUUGAUCAGCUUAGU	ACUAAGCUGAUCAACCCUU		[982-1000]
					418	CCAAUGGAAACCUGGAAGA	UCUUCCAGGUUUCCAUUGG		[2577-2595]
419	AAAUAAGUCAGUUAAAGCA	UGCUUUAACUGACUUAUUU	Ms	[2086-2104]
					420	AGCAGCAGAUUGAAAAUCA	UGAUUUUCAAUCUGCUGCU		[699-717]
421	GAAGCAGGAAGUACAGACU	AGUCUGUACUUCCUGCUUC		[955-973]
					422	CUGAAAAUGAAAAGCUUCA	UGAAGCUUUUCAUUUUCAG	Ms	[795-813]
423	GGACCAACUUGAAGAAGCC	GGCUUCUUCAAGUUGGUCC		[2883-2901]
					424	AAGAACUACAGAUUCGUAA	UUACGAAUCUGUAGUUCUU		[1101-1119]
425	CUGCAAUUUUAAGGGUUGA	UCAACCCUUAAAAUUGCAG		[972-990]
					426	CCGAUGAUAUUAACUGUUU	AAACAGUUAAUAUCAUCGG		[290-308]
427	AAUGGAGUCAGGUGCUGGA	UCCAGCACCUGACUCCAUU		[4333-4351]
					428	AAUAAAUGUACCUGGAGAA	UUCUCCAGGUACAUUUAUU		[601-619]
429	CGCCUUAAAUAAGUCAGUU	AACUGACUUAUUUAAGGCG		[2080-2098]
					430	CUGUAUGGAAACAUGUCCA	UGGACAUGUUUCCAUACAG		[4053-4071]
431	UCAGCAGAGGAUUUCCGUA	UACGGAAAUCCUCUGCUGA		[1837-1855]
					432	AAAAUGAAAAGCUUCAGAA	UUCUGAAGCUUUUCAUUUU	Ms	[798-816]
433	GCACAAUAAACCCGUCUCA	UGAGACGGGUUUAUUGUGC		[4934-4952]
					434	GAGAGUUCGAUCUGGUGCA	UGCACCAGAUCGAACUCUC		[2979-2997]
435	CCUCAACCAUAAGCGACAU	AUGUCGCUUAUGGUUGAGG		[3228-3246]

436	AGGUGGAAGAUCCCAGCAA	UUGCUGGGAUCUUCCACCU		[3012-3030]
					437	AGAAAGAGCCUGAGCAGGA	UCCUGCUCAGGCUCUUUCU		[2220-2238]
438	AAGCGGACCAACUUGAAGA	UCUUCAAGUUGGUCCGCUU		[2879-2897]
					439	GUGUGAUGAACAAAGGUGU	ACACCUUUGUUCAUCACAC		[3333-3351]
440	UAACUGUUUUCUUGAGCAA	UUGCUCAAGAAAACAGUUA		[300-318]
					441	AGCACUGACUGUACAUAGU	ACUAUGUACAGUCAGUGCU		[4823-4841]
442	UGUACGUACAGGCUUUUUA	UAAAAAGCCUGUACGUACA		[4625-4643]
					443	GUGUGAGGAGAUGGAGGAA	UUCCUCCAUCUCCUCACAC		[3265-3283]
444	UCUUGAGCAACAAUGAACA	UGUUCAUUGUUGCUCAAGA	大鼠，Ms	[309-327]
					445	GAUUUUGGUGUCAACGUGA	UCACGUUGACACCAAAAUC		[3107-3125]
446	CAGACAGUGAAUUCAAGUU	AACUUGAAUUCACUGUCUG		[1997-2015]
					447	AAAGAAGCAGGAAGUACAG	CUGUACUUCCUGCUUCUUU		[952-970]
448	UUGCCUCAACCAUAAGCGA	UCGCUUAUGGUUGAGGCAA		[3225-3243]
					449	CGUUUUACCUUCGGGUUCA	UGAACCCGAAGGUAAAACG		[2119-2137]
450	UGAAGAAAAUUCGUGCAAU	AUUGCACGAAUUUUCUUCA		[852-870]
					451	CGCUUCCUGUUCCAGUUCA	UGAACUGGAACAGGAAGCG		[4133-4151]
452	ACUGUUUUCUUGAGCAACA	UGUUGCUCAAGAAAACAGU		[302-320]
					453	GCAACAAUGAACAGAUUUU	AAAAUCUGUUCAUUGUUGC	大鼠，Ms	[315-333]
454	AGGCCCUUAGGCUCUAUUU	AAAUAGAGCCUAAGGGCCU		[4724-4742]
					455	GCGAAUCAGUGAACUGCGU	ACGCAGUUCACUGAUUCGC		[1207-1225]
456	CAUUGAAACUGCUGCAGAC	GUCUGCAGCAGUUUCAAUG		[3244-3262]
					457	AGGCUCUAUUUUUCAUGUA	UACAUGAAAAAUAGAGCCU		[4732-4750]
458	CCACCAUCACAUCGUGAAG	CUUCACGAUGUGAUGGUGG		[3079-3097]
					459	UUGCAAGGAACCUGGAGAA	UUCUCCAGGUUCCUUGCAA		[385-403]
460	CUGUUUGGUGCCUGAAGGA	UCCUUCAGGCACCAAACAG		[4432-4450]
					461	CGUGCAAUGAGAGGACAAG	CUUGUCCUCUCAUUGCACG		[863-881]
462	CUGUACCAGCGCUUCAACA	UGUUGAAGCGCUGGUACAG		[2459-2477]

463	CAGAGAAAUGUAAUAAAUG	CAUUUAUUACAUUUCUCUG		[590-608]
					464	CAAUGAUAAUGAGUUACCU	AGGUAACUCAUUAUCAUUG	Ms	[2656-2674]
465	GCUCCUCACAACAGAUUCA	UGAAUCUGUUGUGAGGAGC		[1821-1839]
					466	UUUACAUUUUCUAAAGCAA	UUGCUUUAGAAAAUGUAAA	Ms	[748-766]
467	CUAGGCAACAGCAGCAGAU	AUCUGCUGCUGUUGCCUAG		[690-708]
					468	CGACUACAGCAAAAUCAUG	CAUGAUUUUGCUGUAGUCG		[883-901]
469	AAGGAAAACUGAAUGGGUU	AACCCAUUCAGUUUUCCUU	Ms	[1023-1041]
					470	GCUGAUAGUGAUGGAUGGA	UCCAUCCAUCACUAUCAGC		[3131-3149]
471	CUUAAUGGUGCUCACUUUA	UAAAGUGAGCACCAUUAAG		[3654-3672]
					472	AUAGUGUGGUGAAGAAAAG	CUUUUCUUCACCACACUAU		[4837-4855]
473	CAACCUGUCGAGAUGUUGU	ACAACAUCUCGACAGGUUG		[360-378]
					474	GUGGACAAUGGAAACACCA	UGGUGUUUCCAUUGUCCAC	大鼠	[2555-2573]
475	AAUGGUGCUCACUUUAGCA	UGCUAAAGUGAGCACCAUU		[3657-3675]
					476	AAGCUAUGGGACAUACCCA	UGGGUAUGUCCCAUAGCUU		[1663-1681]
477	AUCUGUCUGCUGAAAUAGA	UCUAUUUCAGCAGACAGAU		[909-927]
					478	UAAAUAAGCGCAACAUGGA	UCCAUGUUGCGCUUAUUUA		[1170-1188]
479	AAAGAAAGGAAAACUGAAU	AUUCAGUUUUCCUUUCUUU	Ms	[1018-1036]
					480	CACCACCUAAGAAUUACCA	UGGUAAUUCUUAGGUGGUG		[2046-2064]
481	CAGGAAAAGCUGGGUGUGA	UCACACCCAGCUUUUCCUG		[3320-3338]
					482	CAAAGCUACCCGAACUAUG	CAUAGUUCGGGUAGCUUUG		[4675-4693]
483	UCACCGAAUCGGACACUCA	UGAGUGUCCGAUUCGGUGA		[3978-3996]
					484	CGUGAAGUUCCUGCUGGAU	AUCCAGCAGGAACUUCACG		[3091-3109]
485	CAGCGCCUUAAAUAAGUCA	UGACUUAUUUAAGGCGCUG		[2077-2095]
					486	CCAUAUACUCCAUGUACCU	AGGUACAUGGAGUAUAUGG		[2016-2034]
487	AGGACGAAAGCGAGACUGA	UCAGUCUCGCUUUCGUCCU		[3438-3456]
					488	AUGAUGCCGAUGAUAUUAA	UUAAUAUCAUCGGCAUCAU	Ms	[284-302]
489	AGUGAAUUCAAGUUCCAUA	UAUGGAACUUGAAUUCACU		[2002-2020]

490	AAGGAACAGCGUUUACAUU	AAUGUAAACGCUGUUCCUU	大鼠，Ms	[737-755]
					491	AGAGGACAAGUCGACUACA	UGUAGUCGACUUGUCCUCU		[872-890]
492	UGCUGGAUUUUGGUGUCAA	UUGACACCAAAAUCCAGCA		[3102-3120]
					493	GUCCCAUACCCUUUGAUCA	UGAUCAAAGGGUAUGGGAC		[444-462]
494	CCCAUACCCUUUGAUCAUA	UAUGAUCAAAGGGUAUGGG		[446-464]
					495	GCAUCGAGAUUGGUAAAGU	ACUUUACCAAUCUCGAUGC		[1605-1623]
496	UGAAGUUCCUGCUGGAUUU	AAAUCCAGCAGGAACUUCA		[3093-3111]
					497	CAGUAUUGCCUCAAAUGCU	AGCAUUUGAGGCAAUACUG		[1393-1411]
498	UGAUAUUAACUGUUUUCUU	AAGAAAACAGUUAAUAUCA		[294-312]
					499	AGAGUGAUGCAGACCUGGA	UCCAGGUCUGCAUCACUCU	Ms	[2340-2358]
500	AAAGUAUUUUUUGACUAGA	UCUAGUCAAAAAAUACUUU		[4651-4669]

表B6 BNIP3-BCL2/腺病毒E1B 19kDa相互作用蛋白3

No.	正义链siRNA	反义链siRNA	其他Sp	人-7669480：127-711
					1	UGAGGAAGAUGAUAUUGAA	UUCAAUAUCAUCUUCCUCA		[411-429]
2	CAACCUUAAUUCAGCUGAA	UUCAGCUGAAUUAAGGUUG		[1046-1064]
					3	GCUAAUUGUUCAUAAUCAA	UUGAUUAUGAACAAUUAGC		[1231-1249]
4	AAAGCAUCUUGAAGAAAAA	UUUUUCUUCAAGAUGCUUU	GP，Chn	[446-464]
					5	AAAAGAAUAGACACUAAAA	UUUUAGUGUCUAUUCUUUU		[857-875]
6	ACACGAGCGUCAUGAAGAA	UUCUUCAUGACGCUCGUGU		[566-584]
					7	GGAACACGAGCGUCAUGAA	UUCAUGACGCUCGUGUUCC		[563-581]
8	CAGGUUGUCUACUAAAGAA	UUCUUUAGUAGACAACCUG		[1195-1213]
					9	CGUUCCUAAUUUAGUAAAA	UUUUACUAAAUUAGGAACG		[837-855]
10	CCAAGGAGUUCCUCUUUAA	UUAAAGAGGAACUCCUUGG		[512-530]
					11	GGAAGAUGAUAUUGAAAGA	UCUUUCAAUAUCAUCUUCC		[414-432]
12	GGGUUUGUCCAAAAUAAAU	AUUUAUUUUGGACAAACCC		[1120-1138]
					13	GGGCAUAUUCUCUGCAGAA	UUCUGCAGAGAAUAUGCCC		[588-606]
14	CUGCAUUGGUGAAUUUAAU	AUUAAAUUCACCAAUGCAG		[1413-1431]

15	GCUUUUGCAUUAUAAGGAA	UUCCUUAUAAUGCAAAAGC		[1308-1326]
					16	AAAUCAUGUUGAUCUAUAA	UUAUAGAUCAACAUGAUUU		[873-891]
17	GAAUGAAUAACAUUGAUAA	UUAUCAAUGUUAUUCAUUC		[1083-1101]
					18	CCUCGGUUUCUAUUUAUAA	UUAUAAAUAGAAACCGAGG		[227-245]
19	GUGAAAAUUUGGUAGUAAA	UUUACUACCAAAUUUUCAC		[939-957]
					20	GAUGCAGGUUGUCUACUAA	UUAGUAGACAACCUGCAUC		[1191-1209]
21	CAGCUUUAUUCUAAGCAAA	UUUGCUUAGAAUAAAGCUG		[1470-1488]
					22	CAAGGAGUUCCUCUUUAAA	UUUAAAGAGGAACUCCUUG		[513-531]
23	CUGCGUUCCUAAUUUAGUA	UACUAAAUUAGGAACGCAG		[834-852]
					24	UGUUCAUAAUCAACAGAAA	UUUCUGUUGAUUAUGAACA		[1237-1255]
25	GAGGAAGAUGAUAUUGAAA	UUUCAAUAUCAUCUUCCUC		[412-430]
					26	UGGAGACAUGGAAAAAAUA	UAUUUUUUCCAUGUCUCCA		[246-264]
27	GAAAGCAUCUUGAAGAAAA	UUUUCUUCAAGAUGCUUUC	GP，Chn	[445-463]
					28	AAAUUAUCUGCAACCUUAA	UUAAGGUUGCAGAUAAUUU		[1036-1054]
29	GGAUGCAGGUUGUCUACUA	UAGUAGACAACCUGCAUCC		[1190-1208]
					30	AAGUUGAAAGCAUCUUGAA	UUCAAGAUGCUUUCAACUU	GP，Chn	[440-458]
31	AUAAAAGAAUAGACACUAA	UUAGUGUCUAUUCUUUUAU		[855-873]
					32	GCAGGUUGUCUACUAAAGA	UCUUUAGUAGACAACCUGC		[1194-1212]
33	GCCUCGGUUUCUAUUUAUA	UAUAAAUAGAAACCGAGGC		[226-244]
					34	GCAUUAUAAGGAAUUAAGU	ACUUAAUUCCUUAUAAUGC		[1314-1332]
35	ACACCUAUGGGAUCAAUAA	UUAUUGAUCCCAUAGGUGU		[894-912]
					36	CUAUGCUAAUUGUUCAUAA	UUAUGAACAAUUAGCAUAG		[1227-1245]
37	GAAUAGACACUAAAAUCAU	AUGAUUUUAGUGUCUAUUC		[861-879]
					38	CAACAGAAACCAAGAUAGA	UCUAUCUUGGUUUCUGUUG		[1247-1265]
39	GAUUAAUGUCUACUGUGAA	UUCACAGUAGACAUUAAUC		[925-943]
					40	AAAGAAUAGACACUAAAAU	AUUUUAGUGUCUAUUCUUU		[858-876]
41	CCUUAUAUAUCACACUAUU	AAUAGUGUGAUAUAUAAGG		[1146-1164]

42	CAGGGCUUCUGAAACAGAU	AUCUGUUUCAGAAGCCCUG		[357-375]
					43	CCAUAGCAUUGGAGAGAAA	UUUCUCUCCAAUGCUAUGG		[378-396]
44	GGUUUGUCCAAAAUAAAUA	UAUUUAUUUUGGACAAACC		[1121-1139]
					45	GAAGUUGAAAGCAUCUUGA	UCAAGAUGCUUUCAACUUC	GP，Chn	[439-457]
46	AAGAAGGAAAGAAGUUGAA	UUCAACUUCUUUCCUUCUU		[429-447]
					47	UAAAAGAAUAGACACUAAA	UUUAGUGUCUAUUCUUUUA		[856-874]
48	UCUGCAUUGGUGAAUUUAA	UUAAAUUCACCAAUGCAGA		[1412-1430]
					49	CACUAUUGUAGAAAGUAUU	AAUACUUUCUACAAUAGUG		[1158-1176]
50	GAAGUACUUUAUAUUUCAA	UUGAAAUAUAAAGUACUUC		[1062-1080]
					51	CAACAUAGCUCACUGAAGA	UCUUCAGUGAGCUAUGUUG		[762-780]
52	CUAAAAUCAUGUUGAUCUA	UAGAUCAACAUGAUUUUAG		[870-888]
					53	GGAAUUAAGUCUCCGAUUA	UAAUCGGAGACUUAAUUCC		[1323-1341]
54	ACACUAUUGUAGAAAGUAU	AUACUUUCUACAAUAGUGU		[1157-1175]
					55	GGAAAGAAGUUGAAAGCAU	AUGCUUUCAACUUCUUUCC	GP，Chn	[434-452]
56	CUCGGUUUCUAUUUAUAAU	AUUAUAAAUAGAAACCGAG		[228-246]
					57	CAUAAUCAACAGAAACCAA	UUGGUUUCUGUUGAUUAUG		[1241-1259]
58	CAGCUGAAGUACUUUAUAU	AUAUAAAGUACUUCAGCUG		[1057-1075]
					59	CAGCCUCGGUUUCUAUUUA	UAAAUAGAAACCGAGGCUG		[224-242]
60	AGGUGAUCACCCUGGAUGA	UCAUCCAGGGUGAUCACCU		[1344-1362]
					61	CAGAAUUUCUGAAAGUUUU	AAAACUUUCAGAAAUUCUG		[602-620]
62	AAACCAAGAUAGAGCUACA	UGUAGCUCUAUCUUGGUUU		[1253-1271]
					63	GAAUUAAGUCUCCGAUUAU	AUAAUCGGAGACUUAAUUC		[1324-1342]
64	GGCCUUAUAUAUCACACUA	UAGUGUGAUAUAUAAGGCC		[1144-1162]
					65	ACACUAAAAUCAUGUUGAU	AUCAACAUGAUUUUAGUGU		[867-885]
66	CCUUAAUUCAGCUGAAGUA	UACUUCAGCUGAAUUAAGG		[1049-1067]
					67	GUACAGUUCGUACACUAAA	UUUAGUGUACGAACUGUAC		[1281-1299]
68	CAAGUCGGCCGGAAAAUAU	AUAUUUUCCGGCCGACUUG		[488-506]

69	AAUAAAAUCGCUACUUUAA	UUAAAGUAGCGAUUUUAUU		[1100-1118]
					70	AACUCUUCUUGCUUUUGCA	UGCAAAAGCAAGAAGAGUU		[1298-1316]
71	CAACAGGGCUUCUGAAACA	UGUUUCAGAAGCCCUGUUG		[354-372]
					72	UGAUCAGUUUUCUGCUGAA	UUCAGCAGAAAACUGAUCA		[1360-1378]
73	UUGAAAGCAUCUUGAAGAA	UUCUUCAAGAUGCUUUCAA	GP，Chn	[443-461]
					74	AGGUUGUCUACUAAAGAAA	UUUCUUUAGUAGACAACCU		[1196-1214]
75	AAAGAAGGAAAGAAGUUGA	UCAACUUCUUUCCUUCUUU		[428-446]
					76	GGGUAGAACUGCACUUCAG	CUGAAGUGCAGUUCUACCC	大鼠，Ms	[179-197]
77	AGAAGGAAAGAAGUUGAAA	UUUCAACUUCUUUCCUUCU	Chn	[430-448]
					78	GAUGAUAUUGAAAGAAGGA	UCCUUCUUUCAAUAUCAUC		[418-436]
79	AGCACCUUUUGAUGAAGAA	UUCUUCAUCAAAAGGUGCU		[700-718]
					80	UAAUAAAAUCGCUACUUUA	UAAAGUAGCGAUUUUAUUA		[1099-1117]
81	AUAGCAUUGGAGAGAAAAA	UUUUUCUCUCCAAUGCUAU		[380-398]
					82	GAAGGCACCUACUCAGUAU	AUACUGAGUAGGUGCCUUC		[1376-1394]
83	AGGGCUUCUGAAACAGAUA	UAUCUGUUUCAGAAGCCCU		[358-376]
					84	CCAAGAGCUCUCACUGUGA	UCACAGUGAGAGCUCUUGG	大鼠	[302-320]
85	GUAAAUGCUGCGUUCCUAA	UUAGGAACGCAGCAUUUAC		[827-845]
					86	UCAUGUUGAUCUAUAAUUA	UAAUUAUAGAUCAACAUGA		[876-894]
87	UGAUAUUGAAAGAAGGAAA	UUUCCUUCUUUCAAUAUCA		[420-438]
					88	UCUUGCUUUUGCAUUAUAA	UUAUAAUGCAAAAGCAAGA		[1304-1322]
89	GUGUUUAUUUGUUCUGUAA	UUACAGAACAAAUAAACAC		[812-830]
					90	UCAGCUUUAUUCUAAGCAA	UUGCUUAGAAUAAAGCUGA		[1469-1487]
91	AGGAGUUCCUCUUUAAACA	UGUUUAAAGAGGAACUCCU	GP	[515-533]
					92	AAGUCGGCCGGAAAAUAUU	AAUAUUUUCCGGCCGACUU		[489-507]
93	GUUGAAAGCAUCUUGAAGA	UCUUCAAGAUGCUUUCAAC	GP，Chn	[442-460]
					94	GUUCGUUAGUGGAUUACUU	AAGUAAUCCACUAACGAAC		[734-752]
95	CAGCUCACAGUCUGAGGAA	UUCCUCAGACUGUGAGCUG		[399-417]

96	UGGAAAAAAUACUGCUGGA	UCCAGCAGUAUUUUUUCCA	大鼠	[254-272]
					97	AUAUCACACUAUUGUAGAA	UUCUACAAUAGUGUGAUAU		[1152-1170]
98	CAUCUUGAAGAAAAACUCA	UGAGUUUUUCUUCAAGAUG	Chn	[450-468]
					99	AGCAUGUCAGACUGAUUAA	UUAAUCAGUCUGACAUGCU		[912-930]
100	AUGGAGACAUGGAAAAAAU	AUUUUUUCCAUGUCUCCAU		[245-263]
					101	CACUGAAGAGCUGUUAGAU	AUCUAACAGCUCUUCAGUG		[772-790]
102	UACCAACAGGGCUUCUGAA	UUCAGAAGCCCUGUUGGUA		[351-369]
					103	GAUCUAUAAUUACACCUAU	AUAGGUGUAAUUAUAGAUC		[883-901]
104	GUUGUCUACUAAAGAAAGA	UCUUUCUUUAGUAGACAAC		[1198-1216]
					105	UCAAAAGAAUGAAUAACAU	AUGUUAUUCAUUCUUUUGA		[1077-1095]
106	CGAGCGUCAUGAAGAAAGG	CCUUUCUUCAUGACGCUCG		[569-587]
					107	UGCUGAAGGCACCUACUCA	UGAGUAGGUGCCUUCAGCA		[1372-1390]
108	GCACCUACUCAGUAUCUUU	AAAGAUACUGAGUAGGUGC		[1380-1398]
					109	AAAAUUAUCUGCAACCUUA	UAAGGUUGCAGAUAAUUUU		[1035-1053]
110	CAGUCUGAGGAAGAUGAUA	UAUCAUCUUCCUCAGACUG		[406-424]
					111	UCAGCUGAAGUACUUUAUA	UAUAAAGUACUUCAGCUGA		[1056-1074]
112	UGGAUAUGGGAUUGGUCAA	UUGACCAAUCCCAUAUCCA	大鼠，Ms，GP，Chn	[472-490]
					113	ACUAUUGUAGAAAGUAUUA	UAAUACUUUCUACAAUAGU		[1159-1177]
114	UGCUAAUUGUUCAUAAUCA	UGAUUAUGAACAAUUAGCA		[1230-1248]
					115	GCCUUAUAUAUCACACUAU	AUAGUGUGAUAUAUAAGGC		[1145-1163]
116	CAUUGAUAAUAAAAUCGCU	AGCGAUUUUAUUAUCAAUG		[1093-1111]
					117	GUUUGUCCAAAAUAAAUAU	AUAUUUAUUUUGGACAAAC		[1122-1140]
118	GAACUGCACUUCAGCAAUA	UAUUGCUGAAGUGCAGUUC		[184-202]
					119	GUUCGUACACUAAACUCUU	AAGAGUUUAGUGUACGAAC		[1286-1304]
120	AAGAAUGAAUAACAUUGAU	AUCAAUGUUAUUCAUUCUU		[1081-1099]
					121	GUUAGUGGAUUACUUCUGA	UCAGAAGUAAUCCACUAAC		[738-756]
122	GAUCAAUAAGCAUGUCAGA	UCUGACAUGCUUAUUGAUC		[904-922]

123	CCAAGAUAGAGCUACAAAC	GUUUGUAGCUCUAUCUUGG		[1256-1274]
					124	CUACUAAAGAAAGAUUAUA	UAUAAUCUUUCUUUAGUAG		[1203-1221]
125	UGAUCACCCUGGAUGAUCA	UGAUCAUCCAGGGUGAUCA		[1347-1365]
					126	AAUGGAGACAUGGAAAAAA	UUUUUUCCAUGUCUCCAUU		[244-262]
127	UGGGUAGAACUGCACUUCA	UGAAGUGCAGUUCUACCCA	大鼠，Ms	[178-196]
					128	AGAAUAGACACUAAAAUCA	UGAUUUUAGUGUCUAUUCU		[860-878]
129	CAAGAUAGAGCUACAAACU	AGUUUGUAGCUCUAUCUUG		[1257-1275]
					130	AGAUAGAGCUACAAACUCA	UGAGUUUGUAGCUCUAUCU		[1259-1277]
131	UGAAGUACUUUAUAUUUCA	UGAAAUAUAAAGUACUUCA		[1061-1079]
					132	GGUUUCUAUUUAUAAUGGA	UCCAUUAUAAAUAGAAACC		[231-249]
133	UAUGCUAAUUGUUCAUAAU	AUUAUGAACAAUUAGCAUA		[1228-1246]
					134	UGUCCAAAAUAAAUAUUGU	ACAAUAUUUAUUUUGGACA		[1125-1143]
135	AAUGGAUGCAGGUUGUCUA	UAGACAACCUGCAUCCAUU		[1187-1205]
					136	UGUACAGUUCGUACACUAA	UUAGUGUACGAACUGUACA		[1280-1298]
137	CACCCUGGAUGAUCAGUUU	AAACUGAUCAUCCAGGGUG		[1351-1369]
					138	ACCAAGAUAGAGCUACAAA	UUUGUAGCUCUAUCUUGGU		[1255-1273]
139	AUUGGAAGGCGUCUGACAA	UUGUCAGACGCCUUCCAAU	大鼠，Ms	[673-691]
					140	UGAGGAACACGAGCGUCAU	AUGACGCUCGUGUUCCUCA		[560-578]
141	GCUUUUAAAAUCAGCUUUA	UAAAGCUGAUUUUAAAAGC		[1459-1477]
					142	GAGAGAAAAACAGCUCACA	UGUGAGCUGUUUUUCUCUC		[389-407]
143	CUGUACAGUUCGUACACUA	UAGUGUACGAACUGUACAG		[1279-1297]
					144	CCCAAGGAGUUCCUCUUUA	UAAAGAGGAACUCCUUGGG		[511-529]
145	GAGACAUGGAAAAAAUACU	AGUAUUUUUUCCAUGUCUC		[248-266]
					146	AACCAAGAUAGAGCUACAA	UUGUAGCUCUAUCUUGGUU		[1254-1272]
147	GAAGAUGAUAUUGAAAGAA	UUCUUUCAAUAUCAUCUUC		[415-433]
					148	GCAUAUUCUCUGCAGAAUU	AAUUCUGCAGAGAAUAUGC		[590-608]
149	ACCAGCACCUUUUGAUGAA	UUCAUCAAAAGGUGCUGGU		[697-715]

150	AAAGAAUGAAUAACAUUGA	UCAAUGUUAUUCAUUCUUU		[1080-1098]
					151	GAAAAACUCAGAUUGGAUA	UAUCCAAUCUGAGUUUUUC	大鼠，Ms，Chn	[459-477]
152	AUGCAGGUUGUCUACUAAA	UUUAGUAGACAACCUGCAU		[1192-1210]
					153	CUGUGAAAAUUUGGUAGUA	UACUACCAAAUUUUCACAG		[937-955]
154	CACGAGCGUCAUGAAGAAA	UUUCUUCAUGACGCUCGUG		[567-585]
					155	GGUUGUCUACUAAAGAAAG	CUUUCUUUAGUAGACAACC		[1197-1215]
156	GGCAUAUUCUCUGCAGAAU	AUUCUGCAGAGAAUAUGCC		[589-607]
					157	UCUUCUUGCUUUUGCAUUA	UAAUGCAAAAGCAAGAAGA		[1301-1319]
158	CAUGAGUCUGGACGGAGUA	UACUCCGUCCAGACUCAUG		[280-298]
					159	CUUCUGAGCUUGCAACAUA	UAUGUUGCAAGCUCAGAAG		[750-768]
160	CAUAUUCUCUGCAGAAUUU	AAAUUCUGCAGAGAAUAUG		[591-609]
					161	UUAUAAUGGAGACAUGGAA	UUCCAUGUCUCCAUUAUAA		[240-258]
162	CUUUUAAAAUCAGCUUUAU	AUAAAGCUGAUUUUAAAAG		[1460-1478]
					163	GUAGUAAAUUUUCAUUUGA	UCAAAUGAAAAUUUACUAC		[950-968]
164	GAGAAAAACAGCUCACAGU	ACUGUGAGCUGUUUUUCUC		[391-409]
					165	CCUAUGGGAUCAAUAAGCA	UGCUUAUUGAUCCCAUAGG		[897-915]
166	CCCAUAGCAUUGGAGAGAA	UUCUCUCCAAUGCUAUGGG		[377-395]
					167	UUGCAUUAUAAGGAAUUAA	UUAAUUCCUUAUAAUGCAA		[1312-1330]
168	GCGUUCCUAAUUUAGUAAA	UUUACUAAAUUAGGAACGC		[836-854]
					169	UAUAUAUCACACUAUUGUA	UACAAUAGUGUGAUAUAUA		[1149-1167]
170	GCAGAAUUUCUGAAAGUUU	AAACUUUCAGAAAUUCUGC		[601-619]
					171	GUCUACUAAAGAAAGAUUA	UAAUCUUUCUUUAGUAGAC		[1201-1219]
172	AAAACAGCUCACAGUCUGA	UCAGACUGUGAGCUGUUUU		[395-413]
					173	CACAGUCUGAGGAAGAUGA	UCAUCUUCCUCAGACUGUG		[404-422]
174	CUACAAACUCAGCUGUACA	UGUACAGCUGAGUUUGUAG		[1267-1285]
					175	GUCUGAGGAAGAUGAUAUU	AAUAUCAUCUUCCUCAGAC		[408-426]
176	UAAUCAACAGAAACCAAGA	UCUUGGUUUCUGUUGAUUA		[1243-1261]

177	AAGAAAAACUCAGAUUGGA	UCCAAUCUGAGUUUUUCUU	大鼠，Ms，Chn	[457-475]
					178	UGAUUAAUGUCUACUGUGA	UCACAGUAGACAUUAAUCA		[924-942]
179	UAACUAUGCUAAUUGUUCA	UGAACAAUUAGCAUAGUUA		[1224-1242]
					180	CCUGGAUGAUCAGUUUUCU	AGAAAACUGAUCAUCCAGG		[1354-1372]
181	CACACUAUUGUAGAAAGUA	UACUUUCUACAAUAGUGUG		[1156-1174]
					182	CUCUGCAGAAUUUCUGAAA	UUUCAGAAAUUCUGCAGAG		[597-615]
183	GGAUGAUCAGUUUUCUGCU	AGCAGAAAACUGAUCAUCC		[1357-1375]
					184	ACUGCACUUCAGCAAUAAU	AUUAUUGCUGAAGUGCAGU		[186-204]
185	GUUCCAGCCUCGGUUUCUA	UAGAAACCGAGGCUGGAAC		[220-238]
					186	GACACUAAAAUCAUGUUGA	UCAACAUGAUUUUAGUGUC		[866-884]
187	AGCUGAAGUACUUUAUAUU	AAUAUAAAGUACUUCAGCU		[1058-1076]
					188	GUUUAUUUGUUCUGUAAAU	AUUUACAGAACAAAUAAAC		[814-832]
189	UGUGAAAAUUUGGUAGUAA	UUACUACCAAAUUUUCACA		[938-956]
					190	AACUGCACUUCAGCAAUAA	UUAUUGCUGAAGUGCAGUU		[185-203]
191	CAUAGCAUUGGAGAGAAAA	UUUUCUCUCCAAUGCUAUG		[379-397]
					192	CUCACAGUCUGAGGAAGAU	AUCUUCCUCAGACUGUGAG		[402-420]
193	UCUACUAAAGAAAGAUUAU	AUAAUCUUUCUUUAGUAGA		[1202-1220]
					194	GCUCACAGUCUGAGGAAGA	UCUUCCUCAGACUGUGAGC		[401-419]
195	CCUGGGUAGAACUGCACUU	AAGUGCAGUUCUACCCAGG	大鼠，Ms	[176-194]
					196	GUUCCUAAUUUAGUAAAAU	AUUUUACUAAAUUAGGAAC		[838-856]
197	AGCCUCGGUUUCUAUUUAU	AUAAAUAGAAACCGAGGCU		[225-243]
					198	UGAAAAUUUGGUAGUAAAU	AUUUACUACCAAAUUUUCA		[940-958]
199	AGCAUUGGAGAGAAAAACA	UGUUUUUCUCUCCAAUGCU		[382-400]
					200	GAAAGAAGUUGAAAGCAUC	GAUGCUUUCAACUUCUUUC	GP，Chn	[435-453]
201	AGUCUGACUUGGUUCGUUA	UAACGAACCAAGUCAGACU		[723-741]
					202	AUACCAACAGGGCUUCUGA	UCAGAAGCCCUGUUGGUAU		[350-368]
203	CAGUAUCUUUUCCUCUUUA	UAAAGAGGAAAAGAUACUG		[1389-1407]

204	GAAGGAAAGAAGUUGAAAG	CUUUCAACUUCUUUCCUUC	Chn	[431-449]
					205	AGAUGAUAUUGAAAGAAGG	CCUUCUUUCAAUAUCAUCU		[417-435]
206	UCUUGAAGAAAAACUCAGA	UCUGAGUUUUUCUUCAAGA	Chn	[452-470]
					207	UAAUGGAGACAUGGAAAAA	UUUUUCCAUGUCUCCAUUA		[243-261]
208	CGUACACUAAACUCUUCUU	AAGAAGAGUUUAGUGUACG		[1289-1307]
					209	CUGAAAGUUUUCCUUCCAU	AUGGAAGGAAAACUUUCAG		[610-628]
210	ACUUCAGCAAUAAUGGGAA	UUCCCAUUAUUGCUGAAGU	Chn	[191-209]
					211	GAAACAGAUACCCAUAGCA	UGCUAUGGGUAUCUGUUUC		[367-385]
212	UCAAGUCGGCCGGAAAAUA	UAUUUUCCGGCCGACUUGA		[487-505]
					213	GCUGCGUUCCUAAUUUAGU	ACUAAAUUAGGAACGCAGC		[833-851]
214	GCAUGUCAGACUGAUUAAU	AUUAAUCAGUCUGACAUGC		[913-931]
					215	UCCUCUUUAAACACCCGAA	UUCGGGUGUUUAAAGAGGA	GP	[521-539]
216	CUGCAACCUUAAUUCAGCU	AGCUGAAUUAAGGUUGCAG		[1043-1061]
					217	CAAAAGAAUGAAUAACAUU	AAUGUUAUUCAUUCUUUUG		[1078-1096]
218	CAGCUGUACAGUUCGUACA	UGUACGAACUGUACAGCUG		[1276-1294]
					219	CUCAGCAUGAGGAACACGA	UCGUGUUCCUCAUGCUGAG		[553-571]
220	UCAGCAUGAGGAACACGAG	CUCGUGUUCCUCAUGCUGA		[554-572]
					221	CAGCACCUUUUGAUGAAGA	UCUUCAUCAAAAGGUGCUG		[699-717]
222	GGUGAUCACCCUGGAUGAU	AUCAUCCAGGGUGAUCACC		[1345-1363]
					223	CAGACUGAUUAAUGUCUAC	GUAGACAUUAAUCAGUCUG		[919-937]
224	AGAAAAACUCAGAUUGGAU	AUCCAAUCUGAGUUUUUCU	大鼠，Ms，Chn	[458-476]
					225	CUGAGGAAGAUGAUAUUGA	UCAAUAUCAUCUUCCUCAG		[410-428]
226	AAUUAUCUGCAACCUUAAU	AUUAAGGUUGCAGAUAAUU		[1037-1055]
					227	CUGCAGAAUUUCUGAAAGU	ACUUUCAGAAAUUCUGCAG		[599-617]
228	GAUUAUAUAUAACUAUGCU	AGCAUAGUUAUAUAUAAUC		[1215-1233]
					229	CAUCUCUGCUGCUCUCUCA	UGAGAGAGCAGCAGAGAUG		[626-644]
230	GGCACCUACUCAGUAUCUU	AAGAUACUGAGUAGGUGCC		[1379-1397]

231	UCGCAGACACCACAAGAUA	UAUCUUGUGGUGUCUGCGA		[334-352]
					232	UGAAGGCACCUACUCAGUA	UACUGAGUAGGUGCCUUCA		[1375-1393]
233	GAAAGUUUUCCUUCCAUCU	AGAUGGAAGGAAAACUUUC		[612-630]
					234	UAUAAUGGAGACAUGGAAA	UUUCCAUGUCUCCAUUAUA		[241-259]
235	UUUGCAUUAUAAGGAAUUA	UAAUUCCUUAUAAUGCAAA		[1311-1329]
					236	AACACGAGCGUCAUGAAGA	UCUUCAUGACGCUCGUGUU		[565-583]
237	CUAUGGGAUCAAUAAGCAU	AUGCUUAUUGAUCCCAUAG		[898-916]
					238	AUUAAUGUCUACUGUGAAA	UUUCACAGUAGACAUUAAU		[926-944]
239	GAUUACUUCUGAGCUUGCA	UGCAAGCUCAGAAGUAAUC		[745-763]
					240	CUUGAAGAAAAACUCAGAU	AUCUGAGUUUUUCUUCAAG	Chn	[453-471]
241	CAGACACCACAAGAUACCA	UGGUAUCUUGUGGUGUCUG	大鼠，Ms	[337-355]
					242	GAUAGAGCUACAAACUCAG	CUGAGUUUGUAGCUCUAUC		[1260-1278]
243	ACAGUCUGAGGAAGAUGAU	AUCAUCUUCCUCAGACUGU		[405-423]
					244	GUGGAUUACUUCUGAGCUU	AAGCUCAGAAGUAAUCCAC		[742-760]
245	AUGCUGCGUUCCUAAUUUA	UAAAUUAGGAACGCAGCAU		[831-849]
					246	GUAAAAUAAAAGAAUAGAC	GUCUAUUCUUUUAUUUUAC		[850-868]
247	UCAGACUGAUUAAUGUCUA	UAGACAUUAAUCAGUCUGA		[918-936]
					248	GACUUGGUUCGUUAGUGGA	UCCACUAACGAACCAAGUC		[728-746]
249	CUAUUGUAGAAAGUAUUAU	AUAAUACUUUCUACAAUAG		[1160-1178]
					250	GCUGAAGUACUUUAUAUUU	AAAUAUAAAGUACUUCAGC		[1059-1077]
251	AAAAUCAGCUUUAUUCUAA	UUAGAAUAAAGCUGAUUUU		[1465-1483]
					252	UGUAAAUGCUGCGUUCCUA	UAGGAACGCAGCAUUUACA		[826-844]
253	ACCAACAGGGCUUCUGAAA	UUUCAGAAGCCCUGUUGGU		[352-370]
					254	UAUUGAAAGAAGGAAAGAA	UUCUUUCCUUCUUUCAAUA		[423-441]
255	UCUGCUGAAGGCACCUACU	AGUAGGUGCCUUCAGCAGA		[1370-1388]
					256	AGGAAAGAAGUUGAAAGCA	UGCUUUCAACUUCUUUCCU	Chn	[433-451]
257	AGCUACAAACUCAGCUGUA	UACAGCUGAGUUUGUAGCU		[1265-1283]

258	CUACUGUGAAAAUUUGGUA	UACCAAAUUUUCACAGUAG		[934-952]
					259	GUAGAACUGCACUUCAGCA	UGCUGAAGUGCAGUUCUAC	大鼠，Ms	[181-199]
260	AGCUUUAUUCUAAGCAAAU	AUUUGCUUAGAAUAAAGCU		[1471-1489]
					261	UGAAAGAAGGAAAGAAGUU	AACUUCUUUCCUUCUUUCA		[426-444]
262	AAGGAAUUAAGUCUCCGAU	AUCGGAGACUUAAUUCCUU		[1321-1339]
					263	GGAGACAUGGAAAAAAUAC	GUAUUUUUUCCAUGUCUCC		[247-265]
264	ACACCACAAGAUACCAACA	UGUUGGUAUCUUGUGGUGU	大鼠，Ms	[340-358]
					265	CAAACUCAGCUGUACAGUU	AACUGUACAGCUGAGUUUG		[1270-1288]
266	AGAAUGAAUAACAUUGAUA	UAUCAAUGUUAUUCAUUCU		[1082-1100]
					267	UUGAAAGAAGGAAAGAAGU	ACUUCUUUCCUUCUUUCAA		[425-443]
268	ACUGGAGUCUGACUUGGUU	AACCAAGUCAGACUCCAGU		[718-736]
					269	UAAGGAAUUAAGUCUCCGA	UCGGAGACUUAAUUCCUUA		[1320-1338]
270	CACCUAUGGGAUCAAUAAG	CUUAUUGAUCCCAUAGGUG		[895-913]
					271	UGGAGAGAAAAACAGCUCA	UGAGCUGUUUUUCUCUCCA		[387-405]
272	AAAUACUGCUGGACGCACA	UGUGCGUCCAGCAGUAUUU		[260-278]
					273	AGGAAUUAAGUCUCCGAUU	AAUCGGAGACUUAAUUCCU		[1322-1340]
274	UGCGUUCCUAAUUUAGUAA	UUACUAAAUUAGGAACGCA		[835-853]
					275	AAGCAUGUCAGACUGAUUA	UAAUCAGUCUGACAUGCUU		[911-929]
276	GAGCUUGCAACAUAGCUCA	UGAGCUAUGUUGCAAGCUC		[755-773]
					277	AAUAAAAGAAUAGACACUA	UAGUGUCUAUUCUUUUAUU		[854-872]
278	CCUCUUUAUCACUCUGCAU	AUGCAGAGUGAUAAAGAGG		[1400-1418]
					279	UUAAUAUACUAGUCAUGAU	AUCAUGACUAGUAUAUUAA		[1001-1019]
280	UCACUGAAGAGCUGUUAGA	UCUAACAGCUCUUCAGUGA		[771-789]
					281	ACAGGGCUUCUGAAACAGA	UCUGUUUCAGAAGCCCUGU		[356-374]
282	GAUCUAUAUUGGAAGGCGU	ACGCCUUCCAAUAUAGAUC		[666-684]
					283	CUUCUUGCUUUUGCAUUAU	AUAAUGCAAAAGCAAGAAG		[1302-1320]
284	AGUUGAAAGCAUCUUGAAG	CUUCAAGAUGCUUUCAACU	GP，Chn	[441-459]

285	AUUUGGUAGUAAAUUUUCA	UGAAAAUUUACUACCAAAU		[945-963]
					286	AUGAAGAACUGGAGUCUGA	UCAGACUCCAGUUCUUCAU		[711-729]
287	ACUCAGAUUGGAUAUGGGA	UCCCAUAUCCAAUCUGAGU	大鼠，Ms，Chn	[464-482]
					288	UGUUUAUUUGUUCUGUAAA	UUUACAGAACAAAUAAACA		[813-831]
289	AUUACUUCUGAGCUUGCAA	UUGCAAGCUCAGAAGUAAU		[746-764]
					290	UGCAACAUAGCUCACUGAA	UUCAGUGAGCUAUGUUGCA		[760-778]
291	AUUAGGUGAUCACCCUGGA	UCCAGGGUGAUCACCUAAU		[1341-1359]
					292	GCAACAUAGCUCACUGAAG	CUUCAGUGAGCUAUGUUGC		[761-779]
293	CUCGCAGACACCACAAGAU	AUCUUGUGGUGUCUGCGAG		[333-351]
					294	UGCAUUAUAAGGAAUUAAG	CUUAAUUCCUUAUAAUGCA		[1313-1331]
295	UGCUUUUGCAUUAUAAGGA	UCCUUAUAAUGCAAAAGCA		[1307-1325]
					296	UCUGAAAGUUUUCCUUCCA	UGGAAGGAAAACUUUCAGA		[609-627]
297	GAACACGAGCGUCAUGAAG	CUUCAUGACGCUCGUGUUC		[564-582]
					298	CUUGCUUUUGCAUUAUAAG	CUUAUAAUGCAAAAGCAAG		[1305-1323]
299	CGCAGACACCACAAGAUAC	GUAUCUUGUGGUGUCUGCG		[335-353]
					300	AAUUAAGUCUCCGAUUAUU	AAUAAUCGGAGACUUAAUU		[1325-1343]
301	AUGUCAGACUGAUUAAUGU	ACAUUAAUCAGUCUGACAU		[915-933]
					302	AAAUCAGCUUUAUUCUAAG	CUUAGAAUAAAGCUGAUUU		[1466-1484]
303	UUGGUUCGUUAGUGGAUUA	UAAUCCACUAACGAACCAA		[731-749]
					304	AAGAGCUCUCACUGUGACA	UGUCACAGUGAGAGCUCUU	大鼠	[304-322]
305	AUAAUGGAGACAUGGAAAA	UUUUCCAUGUCUCCAUUAU		[242-260]
					306	UUCUCUGCAGAAUUUCUGA	UCAGAAAUUCUGCAGAGAA		[595-613]
307	GAUUGGAUAUGGGAUUGGU	ACCAAUCCCAUAUCCAAUC	大鼠，Ms，GP，Chn	[469-487]
					308	AUAUAACUAUGCUAAUUGU	ACAAUUAGCAUAGUUAUAU		[1221-1239]
309	AUUAAGUCUCCGAUUAUUA	UAAUAAUCGGAGACUUAAU		[1326-1344]
					310	CUCAGAUUGGAUAUGGGAU	AUCCCAUAUCCAAUCUGAG	大鼠，Ms，Chn	[465-483]
311	CUCUGCAUUGGUGAAUUUA	UAAAUUCACCAAUGCAGAG		[1411-1429]

312	AGAGAAAAACAGCUCACAG	CUGUGAGCUGUUUUUCUCU		[390-408]
					313	CUUUUGCAUUAUAAGGAAU	AUUCCUUAUAAUGCAAAAG		[1309-1327]
314	CUCCACCAGCACCUUUUGA	UCAAAAGGUGCUGGUGGAG		[693-711]
					315	CUGAAGGCACCUACUCAGU	ACUGAGUAGGUGCCUUCAG		[1374-1392]
316	UAUUGGAAGGCGUCUGACA	UGUCAGACGCCUUCCAAUA		[672-690]
					317	CACCAGCACCUUUUGAUGA	UCAUCAAAAGGUGCUGGUG		[696-714]
318	GAAAAACAGCUCACAGUCU	AGACUGUGAGCUGUUUUUC		[393-411]
					319	UAAUGUCUACUGUGAAAAU	AUUUUCACAGUAGACAUUA		[928-946]
320	UAAAAUCAGCUUUAUUCUA	UAGAAUAAAGCUGAUUUUA		[1464-1482]
					321	CACCUACUCAGUAUCUUUU	AAAAGAUACUGAGUAGGUG		[1381-1399]
322	UGAAAGCAUCUUGAAGAAA	UUUCUUCAAGAUGCUUUCA	GP，Chn	[444-462]
					323	GAAGAAAAACUCAGAUUGG	CCAAUCUGAGUUUUUCUUC	大鼠，Ms，Chn	[456-474]
324	ACACUAAACUCUUCUUGCU	AGCAAGAAGAGUUUAGUGU		[1292-1310]
					325	UACACCUAUGGGAUCAAUA	UAUUGAUCCCAUAGGUGUA		[893-911]
326	GGUUCGUUAGUGGAUUACU	AGUAAUCCACUAACGAACC		[733-751]
					327	CUAAACUCUUCUUGCUUUU	AAAAGCAAGAAGAGUUUAG		[1295-1313]
328	AUGUUGAUCUAUAAUUACA	UGUAAUUAUAGAUCAACAU		[878-896]
					329	AGACACCACAAGAUACCAA	UUGGUAUCUUGUGGUGUCU	大鼠，Ms	[338-356]
330	UCUGAAACAGAUACCCAUA	UAUGGGUAUCUGUUUCAGA		[364-382]
					331	GAAGAACUGGAGUCUGACU	AGUCAGACUCCAGUUCUUC		[713-731]
332	AACAGAUACCCAUAGCAUU	AAUGCUAUGGGUAUCUGUU		[369-387]
					333	CCACCAGCACCUUUUGAUG	CAUCAAAAGGUGCUGGUGG		[695-713]
334	GGAUCAAUAAGCAUGUCAG	CUGACAUGCUUAUUGAUCC		[903-921]
					335	GGUAGUAAAUUUUCAUUUG	CAAAUGAAAAUUUACUACC		[949-967]
336	AAAAUCAUGUUGAUCUAUA	UAUAGAUCAACAUGAUUUU		[872-890]
					337	CACUAAACUCUUCUUGCUU	AAGCAAGAAGAGUUUAGUG		[1293-1311]
338	AAUAGACACUAAAAUCAUG	CAUGAUUUUAGUGUCUAUU		[862-880]

339	AGAACUGCACUUCAGCAAU	AUUGCUGAAGUGCAGUUCU	大鼠，Ms	[183-201]
					340	UCCUCUUUAUCACUCUGCA	UGCAGAGUGAUAAAGAGGA		[1399-1417]
341	CAUGUUGAUCUAUAAUUAC	GUAAUUAUAGAUCAACAUG		[877-895]
					342	AGAUACCCAUAGCAUUGGA	UCCAAUGCUAUGGGUAUCU		[372-390]
343	GUCAAGUCGGCCGGAAAAU	AUUUUCCGGCCGACUUGAC		[486-504]
					344	UAUAAUUACACCUAUGGGA	UCCCAUAGGUGUAAUUAUA		[887-905]
345	GAGUCUGACUUGGUUCGUU	AACGAACCAAGUCAGACUC		[722-740]
					346	AAUCAUGUUGAUCUAUAAU	AUUAUAGAUCAACAUGAUU		[874-892]
347	CAAGAUACCAACAGGGCUU	AAGCCCUGUUGGUAUCUUG		[346-364]
					348	UGAUCUAUAAUUACACCUA	UAGGUGUAAUUAUAGAUCA		[882-900]
349	CUUUUGAUGAAGAACUGGA	UCCAGUUCUUCAUCAAAAG		[705-723]
					350	GCAUCUUGAAGAAAAACUC	GAGUUUUUCUUCAAGAUGC	GP，Chn	[449-467]
351	UAUCUGCAACCUUAAUUCA	UGAAUUAAGGUUGCAGAUA		[1040-1058]
					352	AAUUGUUCAUAAUCAACAG	CUGUUGAUUAUGAACAAUU		[1234-1252]
353	CAGUUUUCUGCUGAAGGCA	UGCCUUCAGCAGAAAACUG		[1364-1382]
					354	AAAUAAAAGAAUAGACACU	AGUGUCUAUUCUUUUAUUU		[853-871]
355	UCUCUGCAGAAUUUCUGAA	UUCAGAAAUUCUGCAGAGA		[596-614]
					356	GCAUUGGAGAGAAAAACAG	CUGUUUUUCUCUCCAAUGC		[383-401]
357	CCAGCCUCGGUUUCUAUUU	AAAUAGAAACCGAGGCUGG		[223-241]
					358	AACUAUGCUAAUUGUUCAU	AUGAACAAUUAGCAUAGUU		[1225-1243]
359	CUUGGUUCGUUAGUGGAUU	AAUCCACUAACGAACCAAG		[730-748]
					360	CGGUUUCUAUUUAUAAUGG	CCAUUAUAAAUAGAAACCG		[230-248]
361	GGAGAGAAAAACAGCUCAC	GUGAGCUGUUUUUCUCUCC		[388-406]
					362	UAAGCAUGUCAGACUGAUU	AAUCAGUCUGACAUGCUUA		[910-928]
363	CAUUAUAAGGAAUUAAGUC	GACUUAAUUCCUUAUAAUG		[1315-1333]
					364	UCACACUAUUGUAGAAAGU	ACUUUCUACAAUAGUGUGA		[1155-1173]
365	CAGAAACCAAGAUAGAGCU	AGCUCUAUCUUGGUUUCUG		[1250-1268]

366	AUGAUAUUGAAAGAAGGAA	UUCCUUCUUUCAAUAUCAU		[419-437]
					367	CACUCUGCAUUGGUGAAUU	AAUUCACCAAUGCAGAGUG		[1409-1427]
368	ACUGAUUAAUGUCUACUGU	ACAGUAGACAUUAAUCAGU		[922-940]
					369	UCAUAAUCAACAGAAACCA	UGGUUUCUGUUGAUUAUGA		[1240-1258]
370	AUUGAAAGAAGGAAAGAAG	CUUCUUUCCUUCUUUCAAU		[424-442]
					371	UUCAAAAGAAUGAAUAACA	UGUUAUUCAUUCUUUUGAA		[1076-1094]
372	AAAGAAGUUGAAAGCAUCU	AGAUGCUUUCAACUUCUUU	GP，Chn	[436-454]
					373	UGCAGGUUGUCUACUAAAG	CUUUAGUAGACAACCUGCA		[1193-1211]
374	AAGAAUAGACACUAAAAUC	GAUUUUAGUGUCUAUUCUU		[859-877]
					375	AAACAGAUACCCAUAGCAU	AUGCUAUGGGUAUCUGUUU		[368-386]
376	CCUCUUUAAACACCCGAAG	CUUCGGGUGUUUAAAGAGG	GP	[522-540]
					377	UAGACACUAAAAUCAUGUU	AACAUGAUUUUAGUGUCUA		[864-882]
378	GUCUCCGAUUAUUAGGUGA	UCACCUAAUAAUCGGAGAC		[1331-1349]
					379	AAGUUUUCCUUCCAUCUCU	AGAGAUGGAAGGAAAACUU		[614-632]
380	UUAGGUGAUCACCCUGGAU	AUCCAGGGUGAUCACCUAA		[1342-1360]
					381	GCAACCUUAAUUCAGCUGA	UCAGCUGAAUUAAGGUUGC		[1045-1063]
382	GGGAUCAAUAAGCAUGUCA	UGACAUGCUUAUUGAUCCC		[902-920]
					383	CAUUGGUGAAUUUAAUCCU	AGGAUUAAAUUCACCAAUG		[1416-1434]
384	AAUGCUGCGUUCCUAAUUU	AAAUUAGGAACGCAGCAUU		[830-848]
					385	ACUCUUCUUGCUUUUGCAU	AUGCAAAAGCAAGAAGAGU		[1299-1317]
386	AAAAAUUAUCUGCAACCUU	AAGGUUGCAGAUAAUUUUU		[1034-1052]
					387	AAAAUAAAAGAAUAGACAC	GUGUCUAUUCUUUUAUUUU		[852-870]
388	CAAGAGCUCUCACUGUGAC	GUCACAGUGAGAGCUCUUG	大鼠	[303-321]
					389	CUUCUGAAACAGAUACCCA	UGGGUAUCUGUUUCAGAAG		[362-380]
390	ACAGCUCACAGUCUGAGGA	UCCUCAGACUGUGAGCUGU		[398-416]
					391	GAAAAUUUGGUAGUAAAUU	AAUUUACUACCAAAUUUUC		[941-959]
392	UGCAGAAUUUCUGAAAGUU	AACUUUCAGAAAUUCUGCA		[600-618]

393	GGUAGAACUGCACUUCAGC	GCUGAAGUGCAGUUCUACC	大鼠，Ms	[180-198]
					394	AGUUCGUACACUAAACUCU	AGAGUUUAGUGUACGAACU		[1285-1303]
395	CUCCAAGAGCUCUCACUGU	ACAGUGAGAGCUCUUGGAG	大鼠	[300-318]
					396	GUGCUUUUAAAAUCAGCUU	AAGCUGAUUUUAAAAGCAC		[1457-1475]
397	CUGUAAAUGCUGCGUUCCU	AGGAACGCAGCAUUUACAG		[825-843]
					398	CCAGCACCUUUUGAUGAAG	CUUCAUCAAAAGGUGCUGG		[698-716]
399	CACUUCAGCAAUAAUGGGA	UCCCAUUAUUGCUGAAGUG	Chn	[190-208]
					400	AAUCAACAGAAACCAAGAU	AUCUUGGUUUCUGUUGAUU		[1244-1262]
401	UAGAACUGCACUUCAGCAA	UUGCUGAAGUGCAGUUCUA	大鼠，Ms	[182-200]
					402	CCGAUUAUUAGGUGAUCAC	GUGAUCACCUAAUAAUCGG		[1335-1353]
403	UUUGGUAGUAAAUUUUCAU	AUGAAAAUUUACUACCAAA		[946-964]
					404	CUCAGUAUCUUUUCCUCUU	AAGAGGAAAAGAUACUGAG		[1387-1405]
405	UUCUGAAACAGAUACCCAU	AUGGGUAUCUGUUUCAGAA		[363-381]
					406	UUGGAUAUGGGAUUGGUCA	UGACCAAUCCCAUAUCCAA	大鼠，Ms，GP，Chn	[471-489]
407	GCUCACUGAAGAGCUGUUA	UAACAGCUCUUCAGUGAGC		[769-787]
					408	UCGUUAGUGGAUUACUUCU	AGAAGUAAUCCACUAACGA		[736-754]
409	ACUUGGUUCGUUAGUGGAU	AUCCACUAACGAACCAAGU		[729-747]
					410	GAUAUUGAAAGAAGGAAAG	CUUUCCUUCUUUCAAUAUC		[421-439]
411	CCAACAGGGCUUCUGAAAC	GUUUCAGAAGCCCUGUUGG		[353-371]
					412	UAAUUCAGCUGAAGUACUU	AAGUACUUCAGCUGAAUUA		[1052-1070]
413	UUCUUGCUUUUGCAUUAUA	UAUAAUGCAAAAGCAAGAA		[1303-1321]
					414	GAUCACCCUGGAUGAUCAG	CUGAUCAUCCAGGGUGAUC		[1348-1366]
415	ACCUUAAUUCAGCUGAAGU	ACUUCAGCUGAAUUAAGGU		[1048-1066]
					416	AGUAUCUUUUCCUCUUUAU	AUAAAGAGGAAAAGAUACU		[1390-1408]
417	UACAGUUCGUACACUAAAC	GUUUAGUGUACGAACUGUA		[1282-1300]
					418	CAGCAAUAAUGGGAACGGG	CCCGUUCCCAUUAUUGCUG		[195-213]
419	GCUACAAACUCAGCUGUAC	GUACAGCUGAGUUUGUAGC		[1266-1284]

420	UGUCUACUAAAGAAAGAUU	AAUCUUUCUUUAGUAGACA		[1200-1218]
					421	GGAGUUCCUCUUUAAACAC	GUGUUUAAAGAGGAACUCC	GP	[516-534]
422	GAGCUACAAACUCAGCUGU	ACAGCUGAGUUUGUAGCUC		[1264-1282]
					423	AUGAGGAACACGAGCGUCA	UGACGCUCGUGUUCCUCAU		[559-577]
424	CACCUUUUGAUGAAGAACU	AGUUCUUCAUCAAAAGGUG		[702-720]
					425	UGAAGAGCUGUUAGAUCCU	AGGAUCUAACAGCUCUUCA		[775-793]
426	CCACAAGAUACCAACAGGG	CCCUGUUGGUAUCUUGUGG		[343-361]
					427	CGUUAGUGGAUUACUUCUG	CAGAAGUAAUCCACUAACG		[737-755]
428	ACUCUGCAUUGGUGAAUUU	AAAUUCACCAAUGCAGAGU		[1410-1428]
					429	UCCGAUUAUUAGGUGAUCA	UGAUCACCUAAUAAUCGGA		[1334-1352]
430	GUCCAAAAUAAAUAUUGUG	CACAAUAUUUAUUUUGGAC		[1126-1144]
					431	AGAAACCAAGAUAGAGCUA	UAGCUCUAUCUUGGUUUCU		[1251-1269]
432	GAAAGAAGGAAAGAAGUUG	CAACUUCUUUCCUUCUUUC		[427-445]
					433	AGUCUGAGGAAGAUGAUAU	AUAUCAUCUUCCUCAGACU		[407-425]
434	UGAAUUUAAUCCUCUCCUU	AAGGAGAGGAUUAAAUUCA		[1422-1440]
					435	CUUAUAUAUCACACUAUUG	CAAUAGUGUGAUAUAUAAG		[1147-1165]
436	CUCUGCUGCUCUCUCAUUU	AAAUGAGAGAGCAGCAGAG		[629-647]
					437	CUAUAAUUACACCUAUGGG	CCCAUAGGUGUAAUUAUAG		[886-904]
438	CUCAGCUGUACAGUUCGUA	UACGAACUGUACAGCUGAG		[1274-1292]
					439	AAUUUAAAUGGAUGCAGGU	ACCUGCAUCCAUUUAAAUU		[1181-1199]
440	CAAUAAGCAUGUCAGACUG	CAGUCUGACAUGCUUAUUG		[907-925]
					441	AAAAACUCAGAUUGGAUAU	AUAUCCAAUCUGAGUUUUU	大鼠，Ms，Chn	[460-478]
442	ACCCUCAGCAUGAGGAACA	UGUUCCUCAUGCUGAGGGU		[550-568]
					443	CUGGAUGAUCAGUUUUCUG	CAGAAAACUGAUCAUCCAG		[1355-1373]
444	CAGUUCGUACACUAAACUC	GAGUUUAGUGUACGAACUG		[1284-1302]
					445	AGGCACCUACUCAGUAUCU	AGAUACUGAGUAGGUGCCU		[1378-1396]
446	AGAAGUUGAAAGCAUCUUG	CAAGAUGCUUUCAACUUCU	GP，Chn	[438-456]

447	AUAAAAUCGCUACUUUAAG	CUUAAAGUAGCGAUUUUAU		[1101-1119]
					448	UACUUCUGAGCUUGCAACA	UGUUGCAAGCUCAGAAGUA		[748-766]
449	AUCACUCUGCAUUGGUGAA	UUCACCAAUGCAGAGUGAU		[1407-1425]
					450	UAUAUUGGAAGGCGUCUGA	UCAGACGCCUUCCAAUAUA		[670-688]
451	UUUAUAAUGGAGACAUGGA	UCCAUGUCUCCAUUAUAAA		[239-257]
					452	ACAAGAUACCAACAGGGCU	AGCCCUGUUGGUAUCUUGU		[345-363]
453	GACUGAUUAAUGUCUACUG	CAGUAGACAUUAAUCAGUC		[921-939]
					454	UUGCAACAUAGCUCACUGA	UCAGUGAGCUAUGUUGCAA		[759-777]
455	AGGAACACGAGCGUCAUGA	UCAUGACGCUCGUGUUCCU		[562-580]
					456	UAAUUGUUCAUAAUCAACA	UGUUGAUUAUGAACAAUUA		[1233-1251]
457	AGUGGAUUACUUCUGAGCU	AGCUCAGAAGUAAUCCACU		[741-759]
					458	UUGUCUACUAAAGAAAGAU	AUCUUUCUUUAGUAGACAA		[1199-1217]
459	ACCUUUUGAUGAAGAACUG	CAGUUCUUCAUCAAAAGGU		[703-721]
					460	UAUAUCACACUAUUGUAGA	UCUACAAUAGUGUGAUAUA		[1151-1169]
461	CAUUGGAGAGAAAAACAGC	GCUGUUUUUCUCUCCAAUG		[384-402]
					462	GUAGCUCCAAGAGCUCUCA	UGAGAGCUCUUGGAGCUAC		[296-314]
463	UUCUGAGCUUGCAACAUAG	CUAUGUUGCAAGCUCAGAA		[751-769]
					464	UUAAAUGGAUGCAGGUUGU	ACAACCUGCAUCCAUUUAA		[1184-1202]
465	GCACUUCAGCAAUAAUGGG	CCCAUUAUUGCUGAAGUGC		[189-207]
					466	UGUCUACUGUGAAAAUUUG	CAAAUUUUCACAGUAGACA		[931-949]
467	UGCUGCGUUCCUAAUUUAG	CUAAAUUAGGAACGCAGCA		[832-850]
					468	AACCUUAAUUCAGCUGAAG	CUUCAGCUGAAUUAAGGUU		[1047-1065]
469	UAAAUGCUGCGUUCCUAAU	AUUAGGAACGCAGCAUUUA		[828-846]
					470	UCCACCAGCACCUUUUGAU	AUCAAAAGGUGCUGGUGGA		[694-712]
471	CUUUAUUCUAAGCAAAUCU	AGAUUUGCUUAGAAUAAAG		[1473-1491]
					472	GGGCUUCUGAAACAGAUAC	GUAUCUGUUUCAGAAGCCC		[359-377]
473	GAAUUUAAUCCUCUCCUUU	AAAGGAGAGGAUUAAAUUC		[1423-1441]

474	AAGGAAAGAAGUUGAAAGC	GCUUUCAACUUCUUUCCUU	Chn	[432-450]
					475	AUAAUAAAAUCGCUACUUU	AAAGUAGCGAUUUUAUUAU		[1098-1116]
476	GGAUAUGGGAUUGGUCAAG	CUUGACCAAUCCCAUAUCC	大鼠，Ms，GP，Chn	[473-491]
					477	UCCUGGGUAGAACUGCACU	AGUGCAGUUCUACCCAGGA	大鼠，Ms	[175-193]
478	AUGUCUACUGUGAAAAUUU	AAAUUUUCACAGUAGACAU		[930-948]
					479	UUCAGCUGAAGUACUUUAU	AUAAAGUACUUCAGCUGAA		[1055-1073]
480	UCAGAUUGGAUAUGGGAUU	AAUCCCAUAUCCAAUCUGA	大鼠，Ms，Chn	[466-484]
					481	UUAAGUCUCCGAUUAUUAG	CUAAUAAUCGGAGACUUAA		[1327-1345]
482	UGAUAAUAAAAUCGCUACU	AGUAGCGAUUUUAUUAUCA		[1096-1114]
					483	GCUGUACAGUUCGUACACU	AGUGUACGAACUGUACAGC		[1278-1296]
484	GAUAUGGGAUUGGUCAAGU	ACUUGACCAAUCCCAUAUC	大鼠，Ms，GP，Chn	[474-492]
					485	GUCUGACUUGGUUCGUUAG	CUAACGAACCAAGUCAGAC		[724-742]
486	UUGUUCAUAAUCAACAGAA	UUCUGUUGAUUAUGAACAA		[1236-1254]
					487	AGUCGGCCGGAAAAUAUUC	GAAUAUUUUCCGGCCGACU		[490-508]
488	AUUACACCUAUGGGAUCAA	UUGAUCCCAUAGGUGUAAU		[891-909]
					489	AACUGGAGUCUGACUUGGU	ACCAAGUCAGACUCCAGUU		[717-735]
490	GUUCAUAAUCAACAGAAAC	GUUUCUGUUGAUUAUGAAC		[1238-1256]
					491	AAGAUGAUAUUGAAAGAAG	CUUCUUUCAAUAUCAUCUU		[416-434]
492	UUAUAUAUCACACUAUUGU	ACAAUAGUGUGAUAUAUAA		[1148-1166]
					493	CUGCACUUCAGCAAUAAUG	CAUUAUUGCUGAAGUGCAG		[187-205]
494	AUAUUGAAAGAAGGAAAGA	UCUUUCCUUCUUUCAAUAU		[422-440]
					495	AGAAUUUCUGAAAGUUUUC	GAAAACUUUCAGAAAUUCU		[603-621]
496	AAAUGCUGCGUUCCUAAUU	AAUUAGGAACGCAGCAUUU		[829-847]
					497	AUUCAGCUGAAGUACUUUA	UAAAGUACUUCAGCUGAAU		[1054-1072]
498	AUUGAUAAUAAAAUCGCUA	UAGCGAUUUUAUUAUCAAU		[1094-1112]
					499	UAUUCUCUGCAGAAUUUCU	AGAAAUUCUGCAGAGAAUA		[593-611]
500	AACAGAAACCAAGAUAGAG	CUCUAUCUUGGUUUCUGUU		[1248-1266]

501	GUUCAACUUUUGUGUGCUU	AAGCACACAAAAGUUGAAC
					502	UCCUUUGUGUUCAACUUUU	AAAAGUUGAACACAAAGGA

表B7 CAPNS1-钙蛋白酶，小亚单元1

表B8 CASP1-半胱天冬酶1，凋亡相关半胱氨酸肽酶

表B9 CASP12-半胱天冬酶12

No.	正义链siRNA	反义链siRNA	其他Sp	人-109637802：-
					1	UGGUGAAGUUGCUGAUCAA	UUGAUCAGCAACUUCACCA		[297-315]
2	CAGUGGUUAUAAAAGAGAA	UUCUCUUUUAUAACCACUG		[657-675]
					3	GAUACUCAGUGGUUAUAAA	UUUAUAACCACUGAGUAUC		[651-669]
4	GAUGGAAAAUAAUGUAUUA	UAAUACAUUAUUUUCCAUC		[346-364]
					5	CAACAUCCGCAACAAAGAA	UUCUUUGUUGCGGAUGUUG		[559-577]
6	CGAUGACACCAUCUUUGAA	UUCAAAGAUGGUGUCAUCG		[832-850]
					7	GAGUCAUCAUCUAGAGGAA	UUCCUCUAGAUGAUGACUC		[1153-1171]
8	GAAUUAAAACUCAUAAGAA	UUCUUAUGAGUUUUAAUUC		[1276-1294]
					9	GGACUUCAUUGCUUUCAAA	UUUGAAAGCAAUGAAGUCC		[1042-1060]
10	CAACUAUCUUCAUAAUCGA	UCGAUUAUGAAGAUAGUUG		[580-598]
					11	GGAGAGCAAGCCUGUUGAA	UUCAACAGGCUUGCUCUCC		[189-207]
12	GCACAUUCCUGGUGUUUAU	AUAAACACCAGGAAUGUGC	Ms	[747-765]
					13	CCAGAGUCUGAAAGACAAA	UUUGUCUUUCAGACUCUGG		[871-889]

14	CCUGUGGAAUUCCAAAAAA	UUUUUUGGAAUUCCACAGG		[484-502]
					15	CCAAGGUCAUCAUCAUGCA	UGCAUGAUGAUGACCUUGG		[891-909]
16	CCAUCUUUGAAAUUUUCAA	UUGAAAAUUUCAAAGAUGG		[840-858]
					17	CAAGGUCAUCAUCAUGCAA	UUGCAUGAUGAUGACCUUG		[892-910]
18	CAGGCAAAAUAUUUAGGGA	UCCCUAAAUAUUUUGCCUG		[462-480]
					19	CCUCAACAUCCGCAACAAA	UUUGUUGCGGAUGUUGAGG		[556-574]
20	CCAUUCAGGGUAAUAUCAA	UUGAUAUUACCCUGAAUGG		[152-170]
					21	AGCUCAAACUGCAGGCAAA	UUUGCCUGCAGUUUGAGCU		[451-469]
22	AGAUCAGAGUCUAAUUUUA	UAAAAUUAGACUCUGAUCU		[93-111]
					23	CUGUAAUGAUGCUGUUACA	UGUAACAGCAUCAUUACAG		[1006-1024]
24	GCCUCAACAUCCGCAACAA	UUGUUGCGGAUGUUGAGGC		[555-573]
					25	CUCUUUCCUGGGAAUUAAA	UUUAAUUCCCAGGAAAGAG		[1265-1283]
26	AUGAUUUGAUGGAAAAUAA	UUAUUUUCCAUCAAAUCAU		[339-357]
					27	ACACGAGAUCAGAGUCUAA	UUAGACUCUGAUCUCGUGU		[88-106]
28	CAAACUGCAGGCAAAAUAU	AUAUUUUGCCUGCAGUUUG		[455-473]
					29	UCCGCAACAAAGAAUUCAA	UUGAAUUCUUUGUUGCGGA		[564-582]
30	GAUGUGAGAUCUACUUGAA	UUCAAGUAGAUCUCACAUC		[625-643]
					31	CUUGGAGACAUGAAACAAA	UUUGUUUCAUGUCUCCAAG		[1083-1101]
32	AGAUGAGAUACACCUUAUA	UAUAAGGUGUAUCUCAUCU		[370-388]
					33	GGAAAUGGAAACAGCACUA	UAGUGCUGUUUCCAUUUCC		[688-706]
34	UGUGGAAUUCCAAAAAACA	UGUUUUUUGGAAUUCCACA		[486-504]
					35	CCUGGUUGAUGAUAUCACU	AGUGAUAUCAUCAACCAGG		[427-445]
36	GCUCAAACUGCAGGCAAAA	UUUUGCCUGCAGUUUGAGC		[452-470]
					37	CUGAAAACCUGGUUGAUGA	UCAUCAACCAGGUUUUCAG		[420-438]
38	GGAUGUGAGAUCUACUUGA	UCAAGUAGAUCUCACAUCC		[624-642]
					39	CUAUCUUCAUAAUCGAAAU	AUUUCGAUUAUGAAGAUAG		[583-601]
40	GACUAUCCAUGACACGAUA	UAUCGUGUCAUGGAUAGUC		[1239-1257]

41	UGGGAAUUAAAACUCAUAA	UUAUGAGUUUUAAUUCCCA		[1273-1291]
					42	CCUGGGAAUUAAAACUCAU	AUGAGUUUUAAUUCCCAGG		[1271-1289]
43	GUCUGAAAGACAAACCCAA	UUGGGUUUGUCUUUCAGAC		[876-894]
					44	GCAACAAAGAAUUCAACUA	UAGUUGAAUUCUUUGUUGC		[567-585]
45	CCAUGACACGAUAUUUCUA	UAGAAAUAUCGUGUCAUGG		[1245-1263]
					46	CACAGCUCAGGAAAUGGAA	UUCCAUUUCCUGAGCUGUG		[679-697]
47	GUCGGCUCUUGCAAGGUAA	UUACCUUGCAAGAGCCGAC		[984-1002]
					48	CACCACUGACAGUGGAAAA	UUUUCCACUGUCAGUGGUG		[946-964]
49	CUGGGAAUUAAAACUCAUA	UAUGAGUUUUAAUUCCCAG		[1272-1290]
					50	UGUGGUGAGCAAUGCUGAA	UUCAGCAUUGCUCACCACA		[406-424]
51	CACUUUGUUAUGUCAAAAA	UUUUUGACAUAACAAAGUG		[23-41]
					52	AGGACUUCAUUGCUUUCAA	UUGAAAGCAAUGAAGUCCU		[1041-1059]
53	GACCAAGCACUGGGAUCAA	UUGAUCCCAGUGCUUGGUC		[796-814]
					54	GGAAUUAAAACUCAUAAGA	UCUUAUGAGUUUUAAUUCC		[1275-1293]
55	UGAUUUGAUGGAAAAUAAU	AUUAUUUUCCAUCAAAUCA		[340-358]
					56	CUUUGUUAUGUCAAAAAGA	UCUUUUUGACAUAACAAAG		[25-43]
57	GUUUCUUGGAGACAUGAAA	UUUCAUGUCUCCAAGAAAC		[1079-1097]
					58	GAGCAAGCCUGUUGAAAUU	AAUUUCAACAGGCUUGCUC		[192-210]
59	ACACCUGUGGAAUUCCAAA	UUUGGAAUUCCACAGGUGU		[481-499]
					60	AACCCAAGGUCAUCAUCAU	AUGAUGAUGACCUUGGGUU		[888-906]
61	ACAGCUGAGUUCAGAUAUA	UAUAUCUGAACUCAGCUGU		[502-520]
					62	AGCCGGUGCAGAUACUCAU	AUGAGUAUCUGCACCGGCU		[964-982]
63	UGAUGAUAUCACUGAGACA	UGUCUCAGUGAUAUCAUCA		[433-451]
					64	CAACAAAGAAUUCAACUAU	AUAGUUGAAUUCUUUGUUG		[568-586]
65	CCAAAGGAAAGCAGUUAUA	UAUAACUGCUUUCCUUUGG		[70-88]
					66	GCUCUGUCUUCAUUUCCCA	UGGGAAAUGAAGACAGAGC		[1104-1122]
67	GAUACACCUUAUAGGAAAA	UUUUCCUAUAAGGUGUAUC		[376-394]

68	UAAUCGAAAUGGUUCUGAA	UUCAGAACCAUUUCGAUUA		[592-610]
					69	UCAGGAAAUGGAAACAGCA	UGCUGUUUCCAUUUCCUGA		[685-703]
70	CAGAUGAGAUACACCUUAU	AUAAGGUGUAUCUCAUCUG		[369-387]
					71	GGAUACUCAGUGGUUAUAA	UUAUAACCACUGAGUAUCC		[650-668]
72	GUUCAACAUUCAUUUGAGA	UCUCAAAUGAAUGUUGAAC		[1184-1202]
					73	CACCUGUGGAAUUCCAAAA	UUUUGGAAUUCCACAGGUG		[482-500]
74	UCAAAAGGUUCAACAUUCA	UGAAUGUUGAACCUUUUGA		[1177-1195]
					75	UCAACAUCCGCAACAAAGA	UCUUUGUUGCGGAUGUUGA		[558-576]
76	UUUGUUAUGUCAAAAAGAA	UUCUUUUUGACAUAACAAA		[26-44]
					77	CCGCAACAAAGAAUUCAAC	GUUGAAUUCUUUGUUGCGG		[565-583]
78	CGGUGCAGAUACUCAUGGU	ACCAUGAGUAUCUGCACCG		[967-985]
					79	UAGAGGAAAUUUUUCAAAA	UUUUGAAAAAUUUCCUCUA		[1164-1182]
80	CAAAUUAUCUACUACUUCA	UGAAGUAGUAGAUAAUUUG		[1121-1139]
					81	ACUCAGUGGUUAUAAAAGA	UCUUUUAUAACCACUGAGU		[654-672]
82	CAUUCAGGGUAAUAUCAAC	GUUGAUAUUACCCUGAAUG		[153-171]
					83	GGAAAUUUUUCAAAAGGUU	AACCUUUUGAAAAAUUUCC		[1168-1186]
84	AAAGAAAAAGAGAAUUUGA	UCAAAUUCUCUUUUUCUUU		[119-137]
					85	GGUUCAACAUUCAUUUGAG	CUCAAAUGAAUGUUGAACC		[1183-1201]
86	UCUCUUUCCUGGGAAUUAA	UUAAUUCCCAGGAAAGAGA		[1264-1282]
					87	AGGUAACAUCUGUAAUGAU	AUCAUUACAGAUGUUACCU		[997-1015]
88	GGAAAAGCCGGUGCAGAUA	UAUCUGCACCGGCUUUUCC		[959-977]
					89	UGGUGAGCAAUGCUGAAAA	UUUUCAGCAUUGCUCACCA		[408-426]
90	AAUCUUCCACACCACAUAA	UUAUGUGGUGUGGAAGAUU		[1059-1077]
					91	GAACACCUGUGGAAUUCCA	UGGAAUUCCACAGGUGUUC		[479-497]
92	UGAUCAAGACCUUUCUAGA	UCUAGAAAGGUCUUGAUCA		[309-327]
					93	GGUUGAUGAUAUCACUGAG	CUCAGUGAUAUCAUCAACC		[430-448]
94	UAAAGUUUGUGGUGAGCAA	UUGCUCACCACAAACUUUA		[399-417]

95	GCCCACCAUUGAAAGACUA	UAGUCUUUCAAUGGUGGGC		[1225-1243]
					96	AAAGGAAAGCAGUUAUACA	UGUAUAACUGCUUUCCUUU		[72-90]
97	AGGCAAAAUAUUUAGGGAA	UUCCCUAAAUAUUUUGCCU		[463-481]
					98	CUGUCUUCAUUUCCCAAAU	AUUUGGGAAAUGAAGACAG		[1107-1125]
99	CAGAUGUUCUUCACGAUGA	UCAUCGUGAAGAACAUCUG		[819-837]
					100	CAAAGAAUUCAACUAUCUU	AAGAUAGUUGAAUUCUUUG		[571-589]
101	GAUCAGAGUCUAAUUUUAU	AUAAAAUUAGACUCUGAUC		[94-112]
					102	CAGCUGCCCACCAUUGAAA	UUUCAAUGGUGGGCAGCUG		[1220-1238]
103	CUUAUAGGAAAAUGUCUAA	UUAGACAUUUUCCUAUAAG		[383-401]
					104	GGAGAAAGAGAGGCGAACA	UGUUCGCCUCUCUUUCUCC		[530-548]
105	UCCUAUUUUCCAAAGGAAA	UUUCCUUUGGAAAAUAGGA		[61-79]
					106	CGGCUCUUGCAAGGUAACA	UGUUACCUUGCAAGAGCCG		[986-1004]
107	UACAAAGGCUCAUGUGGAA	UUCCACAUGAGCCUUUGUA		[1021-1039]
					108	GAGAAAGAGAGGCGAACAU	AUGUUCGCCUCUCUUUCUC		[531-549]
109	CCAGUGAUGGAGAAAGAGA	UCUCUUUCUCCAUCACUGG		[522-540]
					110	CCAAGCACUGGGAUCAAGA	UCUUGAUCCCAGUGCUUGG		[798-816]
111	AAAUUUUCAACAACCGUAA	UUACGGUUGUUGAAAAUUU		[849-867]
					112	CUAGAGGAAAUUUUUCAAA	UUUGAAAAAUUUCCUCUAG		[1163-1181]
113	CAAAAGGUUCAACAUUCAU	AUGAAUGUUGAACCUUUUG		[1178-1196]
					114	GCAAAAUAUUUAGGGAACA	UGUUCCCUAAAUAUUUUGC		[465-483]
115	AAAUCUUCCACACCACAUA	UAUGUGGUGUGGAAGAUUU		[1058-1076]
					116	UCCACUGAGAGGAGAGCAA	UUGCUCUCCUCUCAGUGGA		[179-197]
117	CAAAGGCUCAUGUGGAAAA	UUUUCCACAUGAGCCUUUG		[1023-1041]
					118	ACUGCAGGCAAAAUAUUUA	UAAAUAUUUUGCCUGCAGU		[458-476]
119	AGAUACACCUUAUAGGAAA	UUUCCUAUAAGGUGUAUCU		[375-393]
					120	CAAGCCUGUUGAAAUUGUU	AACAAUUUCAACAGGCUUG		[195-213]
121	AUCCAGUGAUGGAGAAAGA	UCUUUCUCCAUCACUGGAU		[520-538]

122	AGGCUCAUGUGGAAAAGGA	UCCUUUUCCACAUGAGCCU		[1026-1044]
					123	UCUAGAGGAAAUUUUUCAA	UUGAAAAAUUUCCUCUAGA		[1162-1180]
124	CCCAAAUUAUCUACUACUU	AAGUAGUAGAUAAUUUGGG		[1119-1137]
					125	AAUUGUUUUUGCUUUCACA	UGUGAAAGCAAAAACAAUU		[207-225]
126	CAACAAGCUGGUCCACUGA	UCAGUGGACCAGCUUGUUG		[168-186]
					127	ACCUGUGGAAUUCCAAAAA	UUUUUGGAAUUCCACAGGU		[483-501]
128	UGUGAGAUCUACUUGAAAA	UUUUCAAGUAGAUCUCACA		[627-645]
					129	UCUUCAUUUCCCAAAUUAU	AUAAUUUGGGAAAUGAAGA		[1110-1128]
130	CCACAUAAUGUUUCUUGGA	UCCAAGAAACAUUAUGUGG		[1070-1088]
					131	AUGUGAGAUCUACUUGAAA	UUUCAAGUAGAUCUCACAU		[626-644]
132	UUCUGGUCCACAUGGUGAA	UUCACCAUGUGGACCAGAA		[285-303]
					133	AGUGGUUAUAAAAGAGAAU	AUUCUCUUUUAUAACCACU		[658-676]
134	CCAUUGAAAGACUAUCCAU	AUGGAUAGUCUUUCAAUGG		[1230-1248]
					135	CUCUGUCUUCAUUUCCCAA	UUGGGAAAUGAAGACAGAG		[1105-1123]
136	GAGAUACACCUUAUAGGAA	UUCCUAUAAGGUGUAUCUC		[374-392]
					137	GCAAGGUAACAUCUGUAAU	AUUACAGAUGUUACCUUGC		[994-1012]
138	AAUUCAACUAUCUUCAUAA	UUAUGAAGAUAGUUGAAUU		[576-594]
					139	GUUAUGUCAAAAAGAAGAA	UUCUUCUUUUUGACAUAAC		[29-47]
140	GGGAAUUAAAACUCAUAAG	CUUAUGAGUUUUAAUUCCC		[1274-1292]
					141	UGGAAAAGCCGGUGCAGAU	AUCUGCACCGGCUUUUCCA		[958-976]
142	UGUCACAUAGCAUCCUGAA	UUCAGGAUGCUAUGUGACA		[765-783]
					143	CAGCUGAGUUCAGAUAUAU	AUAUAUCUGAACUCAGCUG		[503-521]
144	GAAAUGGAAACAGCACUAA	UUAGUGCUGUUUCCAUUUC		[689-707]
					145	GAAUCUCACAGCUCAGGAA	UUCCUGAGCUGUGAGAUUC		[673-691]
146	CCUUAUAGGAAAAUGUCUA	UAGACAUUUUCCUAUAAGG		[382-400]
					147	UGGUCCACAUGGUGAAGUU	AACUUCACCAUGUGGACCA		[288-306]
148	GAAUUCAACUAUCUUCAUA	UAUGAAGAUAGUUGAAUUC		[575-593]

149	GCUGAUCAAGACCUUUCUA	UAGAAAGGUCUUGAUCAGC		[307-325]
					150	AGAGCAAGCCUGUUGAAAU	AUUUCAACAGGCUUGCUCU		[191-209]
151	CGCAACAAAGAAUUCAACU	AGUUGAAUUCUUUGUUGCG		[566-584]
					152	ACACCAUCUUUGAAAUUUU	AAAAUUUCAAAGAUGGUGU		[837-855]
153	UUCCUAUUUUCCAAAGGAA	UUCCUUUGGAAAAUAGGAA		[60-78]
					154	CUUGGAGUCAUCAUCUAGA	UCUAGAUGAUGACUCCAAG		[1149-1167]
155	AAUUUUCCAUUCAGGGUAA	UUACCCUGAAUGGAAAAUU		[146-164]
					156	CAGUGAUGGAGAAAGAGAG	CUCUCUUUCUCCAUCACUG		[523-541]
157	ACAGCUCAGGAAAUGGAAA	UUUCCAUUUCCUGAGCUGU		[680-698]
					158	ACGGUGUUCUGGUCCACAU	AUGUGGACCAGAACACCGU		[279-297]
159	UGUGGAAAAGGACUUCAUU	AAUGAAGUCCUUUUCCACA		[1033-1051]
					160	UGAGAUACACCUUAUAGGA	UCCUAUAAGGUGUAUCUCA		[373-391]
161	AGGCAAUGGUGCUGGGAUU	AAUCCCAGCACCAUUGCCU		[919-937]
					162	CAGCUCAAACUGCAGGCAA	UUGCCUGCAGUUUGAGCUG		[450-468]
163	UCUGCUUCCUAUUUUCCAA	UUGGAAAAUAGGAAGCAGA		[55-73]
					164	AGAUCUACUUGAAAACCUU	AAGGUUUUCAAGUAGAUCU		[631-649]
165	UUCACUUUGUUAUGUCAAA	UUUGACAUAACAAAGUGAA		[21-39]
					166	GGGAUUGUUUGGUUCACCA	UGGUGAACCAAACAAUCCC		[932-950]
167	UGAAAACCUGGUUGAUGAU	AUCAUCAACCAGGUUUUCA		[421-439]
					168	CUGAUGAGAAACCAUCCAA	UUGGAUGGUUUCUCAUCAG		[261-279]
169	UCAUCUAGAGGAAAUUUUU	AAAAAUUUCCUCUAGAUGA		[1159-1177]
					170	GAAUCUGUGGGACCAAGCA	UGCUUGGUCCCACAGAUUC		[786-804]
171	AACACCUGUGGAAUUCCAA	UUGGAAUUCCACAGGUGUU		[480-498]
					172	AAGACAAACCCAAGGUCAU	AUGACCUUGGGUUUGUCUU		[882-900]
173	GUGGAAUUCCAAAAAACAG	CUGUUUUUUGGAAUUCCAC		[487-505]
					174	GGCUCUUGCAAGGUAACAU	AUGUUACCUUGCAAGAGCC		[987-1005]
175	AACUAUCUUCAUAAUCGAA	UUCGAUUAUGAAGAUAGUU		[581-599]

176	UUGAUGAUUUGAUGGAAAA	UUUUCCAUCAAAUCAUCAA		[336-354]
					177	UGAAAACCUUGGAUACUCA	UGAGUAUCCAAGGUUUUCA		[640-658]
178	AUACUCAGUGGUUAUAAAA	UUUUAUAACCACUGAGUAU		[652-670]
					179	CAUCUGUAAUGAUGCUGUU	AACAGCAUCAUUACAGAUG		[1003-1021]
180	UGGAAACAGCACUAAGGCA	UGCCUUAGUGCUGUUUCCA		[693-711]
					181	AGAUAUAUCCAGUGAUGGA	UCCAUCACUGGAUAUAUCU	大鼠，Ms	[514-532]
182	GAUGAUUUGAUGGAAAAUA	UAUUUUCCAUCAAAUCAUC		[338-356]
					183	AGAAUUUGAGGACUGGGAA	UUCCCAGUCCUCAAAUUCU		[129-147]
184	GAGGACUGGGAAUUUUCCA	UGGAAAAUUCCCAGUCCUC		[136-154]
					185	GCUGAUGAGAAACCAUCCA	UGGAUGGUUUCUCAUCAGC		[260-278]
186	CUUGGAUACUCAGUGGUUA	UAACCACUGAGUAUCCAAG		[647-665]
					187	GGCUCAUGUGGAAAAGGAC	GUCCUUUUCCACAUGAGCC		[1027-1045]
188	AGGAGAGCAAGCCUGUUGA	UCAACAGGCUUGCUCUCCU		[188-206]
					189	CAAUGGUGCUGGGAUUGUU	AACAAUCCCAGCACCAUUG		[922-940]
190	ACAAGCUGGUCCACUGAGA	UCUCAGUGGACCAGCUUGU		[170-188]
					191	UUGGAGACAUGAAACAAAU	AUUUGUUUCAUGUCUCCAA		[1084-1102]
192	CUGUGGAAUUCCAAAAAAC	GUUUUUUGGAAUUCCACAG		[485-503]
					193	GAGAGCAAGCCUGUUGAAA	UUUCAACAGGCUUGCUCUC		[190-208]
194	ACGAGAUCAGAGUCUAAUU	AAUUAGACUCUGAUCUCGU		[90-108]
					195	CUGGGAAUUUUCCAUUCAG	CUGAAUGGAAAAUUCCCAG		[141-159]
196	GUAAUGAUGCUGUUACAAA	UUUGUAACAGCAUCAUUAC		[1008-1026]
					197	GUGUUUAUGUCACAUAGCA	UGCUAUGUGACAUAAACAC		[758-776]
198	GGAAAGCAGUUAUACACGA	UCGUGUAUAACUGCUUUCC		[75-93]
					199	GUCUUCAUUUCCCAAAUUA	UAAUUUGGGAAAUGAAGAC		[1109-1127]
200	CAAAUAUACUGACCCAGCU	AGCUGGGUCAGUAUAUUUG		[1206-1224]
					201	UCCACAUGGUGAAGUUGCU	AGCAACUUCACCAUGUGGA		[291-309]
202	GAAAUUUUCAACAACCGUA	UACGGUUGUUGAAAAUUUC		[848-866]

203	GAGCAAUGCUGAAAACCUG	CAGGUUUUCAGCAUUGCUC		[412-430]
					204	AGAGGAAAUUUUUCAAAAG	CUUUUGAAAAAUUUCCUCU		[1165-1183]
205	GAUGACACCAUCUUUGAAA	UUUCAAAGAUGGUGUCAUC		[833-851]
					206	UCACUUUGUUAUGUCAAAA	UUUUGACAUAACAAAGUGA		[22-40]
207	AUUCAACUAUCUUCAUAAU	AUUAUGAAGAUAGUUGAAU		[577-595]
					208	CUUCCUAUUUUCCAAAGGA	UCCUUUGGAAAAUAGGAAG		[59-77]
209	CACGAUAUUUCUAUCUCUU	AAGAGAUAGAAAUAUCGUG		[1251-1269]
					210	GGAAUUUUCCAUUCAGGGU	ACCCUGAAUGGAAAAUUCC		[144-162]
211	UGCAAGGUAACAUCUGUAA	UUACAGAUGUUACCUUGCA		[993-1011]
					212	UCUUUGAAAUUUUCAACAA	UUGUUGAAAAUUUCAAAGA		[843-861]
213	AGAUGUUCUUCACGAUGAC	GUCAUCGUGAAGAACAUCU		[820-838]
					214	CAUCCUGAAUGGAAUCUGU	ACAGAUUCCAUUCAGGAUG		[775-793]
215	AGUUAUACACGAGAUCAGA	UCUGAUCUCGUGUAUAACU		[82-100]
					216	CUGAGUUCAGAUAUAUCCA	UGGAUAUAUCUGAACUCAG		[506-524]
217	CGAGAUCAGAGUCUAAUUU	AAAUUAGACUCUGAUCUCG		[91-109]
					218	UGAGACAGCUCAAACUGCA	UGCAGUUUGAGCUGUCUCA		[445-463]
219	AGAAUUCAACUAUCUUCAU	AUGAAGAUAGUUGAAUUCU		[574-592]
					220	UGUCAAAAAGAAGAAAACA	UGUUUUCUUCUUUUUGACA		[33-51]
221	AGGGUAAUAUCAACAAGCU	AGCUUGUUGAUAUUACCCU		[158-176]
					222	ACGAUGACACCAUCUUUGA	UCAAAGAUGGUGUCAUCGU		[831-849]
223	CAUAGCAUCCUGAAUGGAA	UUCCAUUCAGGAUGCUAUG		[770-788]
					224	ACAUAAUGUUUCUUGGAGA	UCUCCAAGAAACAUUAUGU		[1072-1090]
225	UCCUGGUGUUUAUGUCACA	UGUGACAUAAACACCAGGA		[753-771]
					226	AAGGUAACAUCUGUAAUGA	UCAUUACAGAUGUUACCUU		[996-1014]
227	GCUGCCCACCAUUGAAAGA	UCUUUCAAUGGUGGGCAGC		[1222-1240]
					228	GAUCAAGACCUUUCUAGAU	AUCUAGAAAGGUCUUGAUC		[310-328]
229	AUGGAGAAAGAGAGGCGAA	UUCGCCUCUCUUUCUCCAU		[528-546]

230	AAUUAAAACUCAUAAGAAG	CUUCUUAUGAGUUUUAAUU		[1277-1295]
					231	GAGAAUUUGAGGACUGGGA	UCCCAGUCCUCAAAUUCUC		[128-146]
232	AAAGGUUCAACAUUCAUUU	AAAUGAAUGUUGAACCUUU		[1180-1198]
					233	UCUUUCCUGGGAAUUAAAA	UUUUAAUUCCCAGGAAAGA		[1266-1284]
234	UGUUAUGUCAAAAAGAAGA	UCUUCUUUUUGACAUAACA		[28-46]
					235	GAAAAUGUCUAAAGUUUGU	ACAAACUUUAGACAUUUUC		[390-408]
236	AGGAAAUUUUUCAAAAGGU	ACCUUUUGAAAAAUUUCCU		[1167-1185]
					237	CAUUCUGUUCACUUUGUUA	UAACAAAGUGAACAGAAUG		[14-32]
238	CUAUCUCUUUCCUGGGAAU	AUUCCCAGGAAAGAGAUAG		[1261-1279]
					239	AUUAAAUACAGAUGAGAUA	UAUCUCAUCUGUAUUUAAU		[361-379]
240	CAGGAAAUGGAAACAGCAC	GUGCUGUUUCCAUUUCCUG		[686-704]
					241	UUUGAUGAUUUGAUGGAAA	UUUCCAUCAAAUCAUCAAA		[335-353]
242	GGUGAGCAAUGCUGAAAAC	GUUUUCAGCAUUGCUCACC		[409-427]
					243	CAAAUCUUCCACACCACAU	AUGUGGUGUGGAAGAUUUG		[1057-1075]
244	UUUUCAAAAGGUUCAACAU	AUGUUGAACCUUUUGAAAA		[1174-1192]
					245	UGCUGAAAACCUGGUUGAU	AUCAACCAGGUUUUCAGCA		[418-436]
246	AAGCCGGUGCAGAUACUCA	UGAGUAUCUGCACCGGCUU		[963-981]
					247	UCCUGGGAAUUAAAACUCA	UGAGUUUUAAUUCCCAGGA		[1270-1288]
248	AUGUGGAAAAGGACUUCAU	AUGAAGUCCUUUUCCACAU		[1032-1050]
					249	GUGAAGUUGCUGAUCAAGA	UCUUGAUCAGCAACUUCAC		[299-317]
250	CUUGCAAGGUAACAUCUGU	ACAGAUGUUACCUUGCAAG		[991-1009]
					251	GAAUUUUCCAUUCAGGGUA	UACCCUGAAUGGAAAAUUC		[145-163]
252	ACACGAUAUUUCUAUCUCU	AGAGAUAGAAAUAUCGUGU		[1250-1268]
					253	UGUUUCUUGGAGACAUGAA	UUCAUGUCUCCAAGAAACA		[1078-1096]
254	AUAGGAAAAUGUCUAAAGU	ACUUUAGACAUUUUCCUAU		[386-404]
					255	UGUUCACUUUGUUAUGUCA	UGACAUAACAAAGUGAACA		[19-37]
256	UGAUGAUUUGAUGGAAAAU	AUUUUCCAUCAAAUCAUCA		[337-355]

257	AAGAGAAUCUCACAGCUCA	UGAGCUGUGAGAUUCUCUU		[669-687]
					258	GUGUUCUGGUCCACAUGGU	ACCAUGUGGACCAGAACAC		[282-300]
259	CACUGAGACAGCUCAAACU	AGUUUGAGCUGUCUCAGUG		[442-460]
					260	CACGAGAUCAGAGUCUAAU	AUUAGACUCUGAUCUCGUG		[89-107]
261	CCUGGUGUUUAUGUCACAU	AUGUGACAUAAACACCAGG		[754-772]
					262	CAUCCAACGGUGUUCUGGU	ACCAGAACACCGUUGGAUG		[273-291]
263	CAAAAAACAGCUGAGUUCA	UGAACUCAGCUGUUUUUUG		[496-514]
					264	GGAAAAGGACUUCAUUGCU	AGCAAUGAAGUCCUUUUCC		[1036-1054]
265	AGGAAAAUGUCUAAAGUUU	AAACUUUAGACAUUUUCCU		[388-406]
					266	UAAAACUCAUAAGAAGCAA	UUGCUUCUUAUGAGUUUUA		[1280-1298]
267	GCUGGGAUUGUUUGGUUCA	UGAACCAAACAAUCCCAGC		[929-947]
					268	CUGCUUCCUAUUUUCCAAA	UUUGGAAAAUAGGAAGCAG		[56-74]
269	GUUGAUGAUAUCACUGAGA	UCUCAGUGAUAUCAUCAAC		[431-449]
					270	UAUCACUGAGACAGCUCAA	UUGAGCUGUCUCAGUGAUA		[439-457]
271	AUUGAAAGACUAUCCAUGA	UCAUGGAUAGUCUUUCAAU		[1232-1250]
					272	ACAUGGUGAAGUUGCUGAU	AUCAGCAACUUCACCAUGU		[294-312]
273	UCAAACUGCAGGCAAAAUA	UAUUUUGCCUGCAGUUUGA		[454-472]
					274	GGCAAAGAAAAAGAGAAUU	AAUUCUCUUUUUCUUUGCC		[116-134]
275	ACAGAUGAGAUACACCUUA	UAAGGUGUAUCUCAUCUGU		[368-386]
					276	GCAUUUUUGAUGAUUUGAU	AUCAAAUCAUCAAAAAUGC		[330-348]
277	UCAUGGUCGGCUCUUGCAA	UUGCAAGAGCCGACCAUGA		[979-997]
					278	UUUGAUGGAAAAUAAUGUA	UACAUUAUUUUCCAUCAAA		[343-361]
279	CCCACCAUUGAAAGACUAU	AUAGUCUUUCAAUGGUGGG		[1226-1244]
					280	AGUCAUCAUCUAGAGGAAA	UUUCCUCUAGAUGAUGACU		[1154-1172]
281	UUAGGGAACACCUGUGGAA	UUCCACAGGUGUUCCCUAA		[474-492]
					282	AAUUUUUCAAAAGGUUCAA	UUGAACCUUUUGAAAAAUU		[1171-1189]
283	AAGAAUUCAACUAUCUUCA	UGAAGAUAGUUGAAUUCUU		[573-591]

284	CUACUACUUCAGAGAGUAU	AUACUCUCUGAAGUAGUAG		[1129-1147]
					285	AAACUGCAGGCAAAAUAUU	AAUAUUUUGCCUGCAGUUU		[456-474]
286	GCCUGUUGAAAUUGUUUUU	AAAAACAAUUUCAACAGGC		[198-216]
					287	AUAGCAUCCUGAAUGGAAU	AUUCCAUUCAGGAUGCUAU		[771-789]
288	UUUUGAUGAUUUGAUGGAA	UUCCAUCAAAUCAUCAAAA		[334-352]
					289	ACUGGGAAUUUUCCAUUCA	UGAAUGGAAAAUUCCCAGU		[140-158]
290	GUAUUAAAUACAGAUGAGA	UCUCAUCUGUAUUUAAUAC		[359-377]
					291	GUCACAUAGCAUCCUGAAU	AUUCAGGAUGCUAUGUGAC		[766-784]
292	GAAACAGCACUAAGGCAGU	ACUGCCUUAGUGCUGUUUC		[695-713]
					293	GAUGGAGAAAGAGAGGCGA	UCGCCUCUCUUUCUCCAUC		[527-545]
294	UUAUGUCAAAAAGAAGAAA	UUUCUUCUUUUUGACAUAA		[30-48]
					295	AAAUGGAAACAGCACUAAG	CUUAGUGCUGUUUCCAUUU		[690-708]
296	GGCAUUUUUGAUGAUUUGA	UCAAAUCAUCAAAAAUGCC		[329-347]
					297	UGGUGUUUAUGUCACAUAG	CUAUGUGACAUAAACACCA		[756-774]
298	GGCUGAUGAGAAACCAUCC	GGAUGGUUUCUCAUCAGCC		[259-277]
					299	GCAAAGAAAAAGAGAAUUU	AAAUUCUCUUUUUCUUUGC		[117-135]
300	UCAUUUCCCAAAUUAUCUA	UAGAUAAUUUGGGAAAUGA		[1113-1131]
					301	CAGAGAGUAUUCUUGGAGU	ACUCCAAGAAUACUCUCUG		[1138-1156]
302	AGACUAUCCAUGACACGAU	AUCGUGUCAUGGAUAGUCU		[1238-1256]
					303	CUGGUGUUUAUGUCACAUA	UAUGUGACAUAAACACCAG		[755-773]
304	UAUGUCAAAAAGAAGAAAA	UUUUCUUCUUUUUGACAUA		[31-49]
					305	GAAUUUGAGGACUGGGAAU	AUUCCCAGUCCUCAAAUUC		[130-148]
306	UGUUGAAAUUGUUUUUGCU	AGCAAAAACAAUUUCAACA		[201-219]
					307	UCACGAUGACACCAUCUUU	AAAGAUGGUGUCAUCGUGA		[829-847]
308	AGUUGCUGAUCAAGACCUU	AAGGUCUUGAUCAGCAACU		[303-321]
					309	UGAAGUUGCUGAUCAAGAC	GUCUUGAUCAGCAACUUCA		[300-318]
310	UCCAUUCAGGGUAAUAUCA	UGAUAUUACCCUGAAUGGA		[151-169]

311	CUUCAUAAUCGAAAUGGUU	AACCAUUUCGAUUAUGAAG		[587-605]
					312	AGGUCAUCAUCAUGCAAGC	GCUUGCAUGAUGAUGACCU		[894-912]
313	GGGUAAUAUCAACAAGCUG	CAGCUUGUUGAUAUUACCC		[159-177]
					314	GGCAAAAUAUUUAGGGAAC	GUUCCCUAAAUAUUUUGCC		[464-482]
315	UAAUGAUGCUGUUACAAAG	CUUUGUAACAGCAUCAUUA		[1009-1027]
					316	CAAAAAGAAGAAAACACCU	AGGUGUUUUCUUCUUUUUG		[36-54]
317	AAAAGCCGGUGCAGAUACU	AGUAUCUGCACCGGCUUUU		[961-979]
					318	CAAGCACUGGGAUCAAGAG	CUCUUGAUCCCAGUGCUUG		[799-817]
319	CAGACAGCACAUUCCUGGU	ACCAGGAAUGUGCUGUCUG	Ms	[741-759]
					320	CUGCAGGCAAAAUAUUUAG	CUAAAUAUUUUGCCUGCAG		[459-477]
321	CAGUCCUCAGACAGCACAU	AUGUGCUGUCUGAGGACUG	Ms	[734-752]
					322	GUUCACUUUGUUAUGUCAA	UUGACAUAACAAAGUGAAC		[20-38]
323	GGAAUUCCAAAAAACAGCU	AGCUGUUUUUUGGAAUUCC		[489-507]
					324	GGAAAAUGUCUAAAGUUUG	CAAACUUUAGACAUUUUCC		[389-407]
325	AAUUAUCUACUACUUCAGA	UCUGAAGUAGUAGAUAAUU		[1123-1141]
					326	UCUUCAUAAUCGAAAUGGU	ACCAUUUCGAUUAUGAAGA		[586-604]
327	UUCAGGGUAAUAUCAACAA	UUGUUGAUAUUACCCUGAA		[155-173]
					328	UUCUUGGAGUCAUCAUCUA	UAGAUGAUGACUCCAAGAA		[1147-1165]
329	GAUGAGAUACACCUUAUAG	CUAUAAGGUGUAUCUCAUC		[371-389]
					330	CUCAGUGGUUAUAAAAGAG	CUCUUUUAUAACCACUGAG		[655-673]
331	CAAGGUAACAUCUGUAAUG	CAUUACAGAUGUUACCUUG		[995-1013]
					332	ACAAAGAAUUCAACUAUCU	AGAUAGUUGAAUUCUUUGU		[570-588]
333	CUUCCACACCACAUAAUGU	ACAUUAUGUGGUGUGGAAG		[1062-1080]
					334	GUUCACCACUGACAGUGGA	UCCACUGUCAGUGGUGAAC		[943-961]
335	UCUUGGAGACAUGAAACAA	UUGUUUCAUGUCUCCAAGA		[1082-1100]
					336	CACACCACAUAAUGUUUCU	AGAAACAUUAUGUGGUGUG		[1066-1084]
337	GUUAUAAAAGAGAAUCUCA	UGAGAUUCUCUUUUAUAAC		[662-680]

338	AGGGAACACCUGUGGAAUU	AAUUCCACAGGUGUUCCCU		[476-494]
					339	UUGCAAGGUAACAUCUGUA	UACAGAUGUUACCUUGCAA		[992-1010]
340	GUUCUGGUCCACAUGGUGA	UCACCAUGUGGACCAGAAC		[284-302]
					341	AGAGGAGAGCAAGCCUGUU	AACAGGCUUGCUCUCCUCU		[186-204]
342	CCUCAGACAGCACAUUCCU	AGGAAUGUGCUGUCUGAGG	Ms	[738-756]
					343	UUUCCCAAAUUAUCUACUA	UAGUAGAUAAUUUGGGAAA		[1116-1134]
344	UCAAAUCUUCCACACCACA	UGUGGUGUGGAAGAUUUGA		[1056-1074]
					345	AACUGCAGGCAAAAUAUUU	AAAUAUUUUGCCUGCAGUU		[457-475]
346	AAAACAGCUGAGUUCAGAU	AUCUGAACUCAGCUGUUUU		[499-517]
					347	CAGUUAUACACGAGAUCAG	CUGAUCUCGUGUAUAACUG		[81-99]
348	GAAAUGGUUCUGAACUUGA	UCAAGUUCAGAACCAUUUC		[597-615]
					349	UUCAGAGAGUAUUCUUGGA	UCCAAGAAUACUCUCUGAA		[1136-1154]
350	CACCAUCUUUGAAAUUUUC	GAAAAUUUCAAAGAUGGUG		[838-856]
					351	CAUGACACGAUAUUUCUAU	AUAGAAAUAUCGUGUCAUG		[1246-1264]
352	AUGUAUUAAAUACAGAUGA	UCAUCUGUAUUUAAUACAU		[357-375]
					353	GGAGUCAUCAUCUAGAGGA	UCCUCUAGAUGAUGACUCC		[1152-1170]
354	UAGGAAAAUGUCUAAAGUU	AACUUUAGACAUUUUCCUA		[387-405]
					355	AAAACCUGGUUGAUGAUAU	AUAUCAUCAACCAGGUUUU		[423-441]
356	GAGUAUUCUUGGAGUCAUC	GAUGACUCCAAGAAUACUC		[1142-1160]
					357	UGAUGGAAAAUAAUGUAUU	AAUACAUUAUUUUCCAUCA		[345-363]
358	AAGCAGUUAUACACGAGAU	AUCUCGUGUAUAACUGCUU		[78-96]
					359	AUGACACCAUCUUUGAAAU	AUUUCAAAGAUGGUGUCAU		[834-852]
360	ACCAUUGAAAGACUAUCCA	UGGAUAGUCUUUCAAUGGU		[1229-1247]
					361	AAACCUGGUUGAUGAUAUC	GAUAUCAUCAACCAGGUUU		[424-442]
362	AAUGGAAACAGCACUAAGG	CCUUAGUGCUGUUUCCAUU		[691-709]
					363	ACAGCACAUUCCUGGUGUU	AACACCAGGAAUGUGCUGU	Ms	[744-762]
364	AGUCUGAAAGACAAACCCA	UGGGUUUGUCUUUCAGACU		[875-893]

365	GCUCAUGUGGAAAAGGACU	AGUCCUUUUCCACAUGAGC		[1028-1046]
					366	GUAAUAUCAACAAGCUGGU	ACCAGCUUGUUGAUAUUAC		[161-179]
367	UCUACUUGAAAACCUUGGA	UCCAAGGUUUUCAAGUAGA		[634-652]
					368	CUUCAUUUCCCAAAUUAUC	GAUAAUUUGGGAAAUGAAG		[1111-1129]
369	AAUGGUGCUGGGAUUGUUU	AAACAAUCCCAGCACCAUU		[923-941]
					370	GCAAGCCUGUUGAAAUUGU	ACAAUUUCAACAGGCUUGC		[194-212]
371	CUUUGAAAUUUUCAACAAC	GUUGUUGAAAAUUUCAAAG		[844-862]
					372	ACUCAUAAGAAGCAACUCA	UGAGUUGCUUCUUAUGAGU		[1284-1302]
373	GAAAGACUAUCCAUGACAC	GUGUCAUGGAUAGUCUUUC		[1235-1253]
					374	GAGAUCAGAGUCUAAUUUU	AAAAUUAGACUCUGAUCUC		[92-110]
375	GAUGUUCUUCACGAUGACA	UGUCAUCGUGAAGAACAUC		[821-839]
					376	GAGGAAAUUUUUCAAAAGG	CCUUUUGAAAAAUUUCCUC		[1166-1184]
377	AGGAAAUGGAAACAGCACU	AGUGCUGUUUCCAUUUCCU		[687-705]
					378	GAAAAGGACUUCAUUGCUU	AAGCAAUGAAGUCCUUUUC		[1037-1055]
379	GGGAAUUUUCCAUUCAGGG	CCCUGAAUGGAAAAUUCCC		[143-161]
					380	UGAUGAGAAACCAUCCAAC	GUUGGAUGGUUUCUCAUCA		[262-280]
381	UGCCCACCAUUGAAAGACU	AGUCUUUCAAUGGUGGGCA		[1224-1242]
					382	ACACCUUAUAGGAAAAUGU	ACAUUUUCCUAUAAGGUGU		[379-397]
383	UAUUAAAUACAGAUGAGAU	AUCUCAUCUGUAUUUAAUA		[360-378]
					384	CAUUUUUGAUGAUUUGAUG	CAUCAAAUCAUCAAAAAUG		[331-349]
385	AAGAGAGGCGAACAUGCCU	AGGCAUGUUCGCCUCUCUU		[535-553]
					386	UGUAAUGAUGCUGUUACAA	UUGUAACAGCAUCAUUACA		[1007-1025]
387	CUACUUGAAAACCUUGGAU	AUCCAAGGUUUUCAAGUAG		[635-653]
					388	UGUUUAUGUCACAUAGCAU	AUGCUAUGUGACAUAAACA		[759-777]
389	CGAUAUUUCUAUCUCUUUC	GAAAGAGAUAGAAAUAUCG		[1253-1271]
					390	UAUAUCCAGUGAUGGAGAA	UUCUCCAUCACUGGAUAUA	大鼠，Ms	[517-535]
391	UGUAUUAAAUACAGAUGAG	CUCAUCUGUAUUUAAUACA		[358-376]

392	ACAUCCGCAACAAAGAAUU	AAUUCUUUGUUGCGGAUGU		[561-579]
					393	GUUUGGUUCACCACUGACA	UGUCAGUGGUGAACCAAAC		[938-956]
394	GAGACAGCUCAAACUGCAG	CUGCAGUUUGAGCUGUCUC		[446-464]
					395	AGCUCAGGAAAUGGAAACA	UGUUUCCAUUUCCUGAGCU		[682-700]
396	AGGUUCAACAUUCAUUUGA	UCAAAUGAAUGUUGAACCU		[1182-1200]
					397	GAAAAAGAGAAUUUGAGGA	UCCUCAAAUUCUCUUUUUC		[122-140]
398	GUGGUGAGCAAUGCUGAAA	UUUCAGCAUUGCUCACCAC		[407-425]
					399	CAAUGCUGAAAACCUGGUU	AACCAGGUUUUCAGCAUUG		[415-433]
400	AAAUUUUUCAAAAGGUUCA	UGAACCUUUUGAAAAAUUU		[1170-1188]
					401	ACUAUCUUCAUAAUCGAAA	UUUCGAUUAUGAAGAUAGU		[582-600]
402	CCUUGGAUACUCAGUGGUU	AACCACUGAGUAUCCAAGG		[646-664]
					403	UAUAAAAGAGAAUCUCACA	UGUGAGAUUCUCUUUUAUA		[664-682]
404	UUGGAUACUCAGUGGUUAU	AUAACCACUGAGUAUCCAA		[648-666]
					405	GCAGUUAUACACGAGAUCA	UGAUCUCGUGUAUAACUGC		[80-98]
406	GAAAGAGAGGCGAACAUGC	GCAUGUUCGCCUCUCUUUC		[533-551]
					407	UGGGAAUUUUCCAUUCAGG	CCUGAAUGGAAAAUUCCCA		[142-160]
408	AUGUCACAUAGCAUCCUGA	UCAGGAUGCUAUGUGACAU		[764-782]
					409	GGCUCUGUCUUCAUUUCCC	GGGAAAUGAAGACAGAGCC		[1103-1121]
410	GCACUAAGGCAGUUUGCUG	CAGCAAACUGCCUUAGUGC		[701-719]
					411	AGGACUGGGAAUUUUCCAU	AUGGAAAAUUCCCAGUCCU		[137-155]
412	CAUGUGGAAAAGGACUUCA	UGAAGUCCUUUUCCACAUG		[1031-1049]
					413	UCACCACUGACAGUGGAAA	UUUCCACUGUCAGUGGUGA		[945-963]
414	UCUACUACUUCAGAGAGUA	UACUCUCUGAAGUAGUAGA		[1128-1146]
					415	UGUCUUCAUUUCCCAAAUU	AAUUUGGGAAAUGAAGACA		[1108-1126]
416	GUCAUCAUCUAGAGGAAAU	AUUUCCUCUAGAUGAUGAC		[1155-1173]
					417	UAACAUCUGUAAUGAUGCU	AGCAUCAUUACAGAUGUUA		[1000-1018]
418	AAAGACAAACCCAAGGUCA	UGACCUUGGGUUUGUCUUU		[881-899]

419	AGCACAUUCCUGGUGUUUA	UAAACACCAGGAAUGUGCU	Ms	[746-764]
					420	CAGAGUCUAAUUUUAUCUU	AAGAUAAAAUUAGACUCUG		[97-115]
421	GAAAUUGUUUUUGCUUUCA	UGAAAGCAAAAACAAUUUC		[205-223]
					422	UGCUGAUCAAGACCUUUCU	AGAAAGGUCUUGAUCAGCA		[306-324]
423	UACACGAGAUCAGAGUCUA	UAGACUCUGAUCUCGUGUA		[87-105]
					424	GAAAACCUGGUUGAUGAUA	UAUCAUCAACCAGGUUUUC		[422-440]
425	UGAGCAAUGCUGAAAACCU	AGGUUUUCAGCAUUGCUCA		[411-429]
					426	CUCAAACUGCAGGCAAAAU	AUUUUGCCUGCAGUUUGAG		[453-471]
427	UCAGGGUAAUAUCAACAAG	CUUGUUGAUAUUACCCUGA		[156-174]
					428	UUUCAAAUCUUCCACACCA	UGGUGUGGAAGAUUUGAAA		[1054-1072]
429	UGGAUACUCAGUGGUUAUA	UAUAACCACUGAGUAUCCA		[649-667]
					430	UAAAUACAGAUGAGAUACA	UGUAUCUCAUCUGUAUUUA		[363-381]
431	AGAGUAUUCUUGGAGUCAU	AUGACUCCAAGAAUACUCU		[1141-1159]
					432	UGGUUAUAAAAGAGAAUCU	AGAUUCUCUUUUAUAACCA		[660-678]
433	CAAAAUAUUUAGGGAACAC	GUGUUCCCUAAAUAUUUUG		[466-484]
					434	AUGGAAUCUGUGGGACCAA	UUGGUCCCACAGAUUCCAU		[783-801]
435	CUCAGGAAAUGGAAACAGC	GCUGUUUCCAUUUCCUGAG		[684-702]
					436	AUAAGAAGCAACUCAGGUA	UACCUGAGUUGCUUCUUAU		[1288-1306]
437	GUAUUCUUGGAGUCAUCAU	AUGAUGACUCCAAGAAUAC		[1144-1162]
					438	GGACUGGGAAUUUUCCAUU	AAUGGAAAAUUCCCAGUCC		[138-156]
439	GGUGAAGUUGCUGAUCAAG	CUUGAUCAGCAACUUCACC		[298-316]
					440	UGGUUGAUGAUAUCACUGA	UCAGUGAUAUCAUCAACCA		[429-447]
441	AACGGUGUUCUGGUCCACA	UGUGGACCAGAACACCGUU		[278-296]
					442	CCUAUUUUCCAAAGGAAAG	CUUUCCUUUGGAAAAUAGG		[62-80]
443	CAUCUAGAGGAAAUUUUUC	GAAAAAUUUCCUCUAGAUG		[1160-1178]
					444	CAUCAUCUAGAGGAAAUUU	AAAUUUCCUCUAGAUGAUG		[1157-1175]
445	UUGUUUGGUUCACCACUGA	UCAGUGGUGAACCAAACAA		[936-954]

446	AAACCCAAGGUCAUCAUCA	UGAUGAUGACCUUGGGUUU		[887-905]
					447	UUGUGGUGAGCAAUGCUGA	UCAGCAUUGCUCACCACAA		[405-423]
448	CACAUGGUGAAGUUGCUGA	UCAGCAACUUCACCAUGUG		[293-311]
					449	AUCUAGAGGAAAUUUUUCA	UGAAAAAUUUCCUCUAGAU		[1161-1179]
450	GUGCUGGGAUUGUUUGGUU	AACCAAACAAUCCCAGCAC		[927-945]
					451	GAGAUCUACUUGAAAACCU	AGGUUUUCAAGUAGAUCUC		[630-648]
452	GUACAUGAUUUCAUUCUGU	ACAGAAUGAAAUCAUGUAC		[3-21]
					453	UCGAAAUGGUUCUGAACUU	AAGUUCAGAACCAUUUCGA		[595-613]
454	CACUGACAGUGGAAAAGCC	GGCUUUUCCACUGUCAGUG		[949-967]
					455	GGUAACAUCUGUAAUGAUG	CAUCAUUACAGAUGUUACC		[998-1016]
456	GUUCAGAUAUAUCCAGUGA	UCACUGGAUAUAUCUGAAC		[510-528]
					457	CUCAUAAGAAGCAACUCAG	CUGAGUUGCUUCUUAUGAG		[1285-1303]
458	AAAAACAGCUGAGUUCAGA	UCUGAACUCAGCUGUUUUU		[498-516]
					459	AUGUCAAAAAGAAGAAAAC	GUUUUCUUCUUUUUGACAU		[32-50]
460	UCAGUGGUUAUAAAAGAGA	UCUCUUUUAUAACCACUGA		[656-674]
					461	CAAAGAAAAAGAGAAUUUG	CAAAUUCUCUUUUUCUUUG		[118-136]
462	AAAAGGUUCAACAUUCAUU	AAUGAAUGUUGAACCUUUU		[1179-1197]
					463	AAAGCAGUUAUACACGAGA	UCUCGUGUAUAACUGCUUU		[77-95]
464	UUACAAAGGCUCAUGUGGA	UCCACAUGAGCCUUUGUAA		[1020-1038]
					465	AUUGCUUUCAAAUCUUCCA	UGGAAGAUUUGAAAGCAAU		[1049-1067]
466	AUAUCAACAAGCUGGUCCA	UGGACCAGCUUGUUGAUAU		[164-182]
					467	UUUCCAUUCAGGGUAAUAU	AUAUUACCCUGAAUGGAAA		[149-167]
468	CUGAAUGGAAUCUGUGGGA	UCCCACAGAUUCCAUUCAG		[779-797]
					469	CUAUCCAUGACACGAUAUU	AAUAUCGUGUCAUGGAUAG		[1241-1259]
470	UCACAGCUCAGGAAAUGGA	UCCAUUUCCUGAGCUGUGA		[678-696]
					471	AAGAAAAAGAGAAUUUGAG	CUCAAAUUCUCUUUUUCUU		[120-138]
472	AACAAAGAAUUCAACUAUC	GAUAGUUGAAUUCUUUGUU		[569-587]

473	AAACAGCUGAGUUCAGAUA	UAUCUGAACUCAGCUGUUU		[500-518]
					474	CCUUCUGCUUCCUAUUUUC	GAAAAUAGGAAGCAGAAGG		[52-70]
475	ACGAUAUUUCUAUCUCUUU	AAAGAGAUAGAAAUAUCGU		[1252-1270]
					476	CAGCACUAAGGCAGUUUGC	GCAAACUGCCUUAGUGCUG		[699-717]
477	UAGGGAACACCUGUGGAAU	AUUCCACAGGUGUUCCCUA		[475-493]
					478	AGAGAAUCUCACAGCUCAG	CUGAGCUGUGAGAUUCUCU		[670-688]
479	UUAUCUACUACUUCAGAGA	UCUCUGAAGUAGUAGAUAA		[1125-1143]
					480	AAAUAUUUAGGGAACACCU	AGGUGUUCCCUAAAUAUUU		[468-486]
481	ACUUUGUUAUGUCAAAAAG	CUUUUUGACAUAACAAAGU		[24-42]
					482	AAAUGGUUCUGAACUUGAC	GUCAAGUUCAGAACCAUUU		[598-616]
483	GAAACCAUCCAACGGUGUU	AACACCGUUGGAUGGUUUC		[268-286]
					484	CAUUGAAAGACUAUCCAUG	CAUGGAUAGUCUUUCAAUG		[1231-1249]
485	UGAAAGACUAUCCAUGACA	UGUCAUGGAUAGUCUUUCA		[1234-1252]
					486	AGCACUAAGGCAGUUUGCU	AGCAAACUGCCUUAGUGCU		[700-718]
487	UGAAAUUUUCAACAACCGU	ACGGUUGUUGAAAAUUUCA		[847-865]
					488	GAGAAACCAUCCAACGGUG	CACCGUUGGAUGGUUUCUC		[266-284]
489	GAUUUGAUGGAAAAUAAUG	CAUUAUUUUCCAUCAAAUC		[341-359]
					490	AUGCUGAAAACCUGGUUGA	UCAACCAGGUUUUCAGCAU		[417-435]
491	AUCACUGAGACAGCUCAAA	UUUGAGCUGUCUCAGUGAU		[440-458]
					492	UCAUCAUCUAGAGGAAAUU	AAUUUCCUCUAGAUGAUGA		[1156-1174]
493	UUAUAGGAAAAUGUCUAAA	UUUAGACAUUUUCCUAUAA		[384-402]
					494	AAAAGGACUUCAUUGCUUU	AAAGCAAUGAAGUCCUUUU		[1038-1056]
495	CAUGAUUUCAUUCUGUUCA	UGAACAGAAUGAAAUCAUG		[6-24]
					496	ACCAUCUUUGAAAUUUUCA	UGAAAAUUUCAAAGAUGGU		[839-857]
497	AUCUCACAGCUCAGGAAAU	AUUUCCUGAGCUGUGAGAU		[675-693]
					498	AUUUGAUGGAAAAUAAUGU	ACAUUAUUUUCCAUCAAAU		[342-360]
499	CUUCAUUGCUUUCAAAUCU	AGAUUUGAAAGCAAUGAAG		[1045-1063]

500

UCUGUCUUCAUUUCCCAAA

UUUGGGAAAUGAAGACAGA

[1106-1124]

表B 10 CASP2-半胱天冬酶2，凋亡相关半胱氨酸肽酶

表B 11CASP3-半胱天冬酶3，凋亡相关半胱氨酸肽酶

表B 12CTSD-组织蛋白酶D

No.	正义链siRNA	反义链siRNA	其他Sp	人-23110949：134-1372
					1	CUUGCUGGAUCCACCACAA	UUGUGGUGGAUCCAGCAAG		[480-498]
2	CCGAGGUGCUCAAGAACUA	UAGUUCUUGAGCACCUCGG		[336-354]
					3	GGAUCCACCACAAGUACAA	UUGUACUUGUGGUGGAUCC		[486-504]
4	CAGCUGACAUGGAAAUACA	UGUAUUUCCAUGUCAGCUG		[2078-2096]
					5	CAGACUCCAAGUAUUACAA	UUGUAAUACUUGGAGUCUG		[882-900]
6	GCUGGAUCCACCACAAGUA	UACUUGUGGUGGAUCCAGC		[483-501]
					7	CCGUCUUCGACAACCUGAU	AUCAGGUUGUCGAAGACGG		[771-789]
8	CAGAGGACUACACGCUCAA	UUGAGCGUGUAGUCCUCUG		[1185-1203]
					9	ACAACCUGAUGCAGCAGAA	UUCUGCUGCAUCAGGUUGU		[780-798]
10	ACCUGAAUGUCACCCGCAA	UUGCGGGUGACAUUCAGGU		[915-933]
					11	AGAAGCUGGUGGACCAGAA	UUCUGGUCCACCAGCUUCU		[795-813]
12	CCAGCACCUACGUGAAGAA	UUCUUCACGUAGGUGCUGG		[516-534]
					13	GGCACAGACUCCAAGUAUU	AAUACUUGGAGUCUGUGCC		[878-896]
14	ACUGAAGCUGGGAGGCAAA	UUUGCCUCCCAGCUUCAGU		[1150-1168]
					15	AGAACUACAUGGACGCCCA	UGGGCGUCCAUGUAGUUCU		[348-366]
16	UGUUUGACCGUGACAACAA	UUGUUGUCACGGUCAAACA		[1320-1338]
					17	GCACAGACUCCAAGUAUUA	UAAUACUUGGAGUCUGUGC		[879-897]
18	ACAUGGACGCCCAGUACUA	UAGUACUGGGCGUCCAUGU		[354-372]

19	CCUCGUUUGACAUCCACUA	UAGUGGAUGUCAAACGAGG		[540-558]
					20	UCUGUUUCGUGCAUUGGAA	UUCCAAUGCACGAAACAGA		[1624-1642]
21	GUUUGACCGUGACAACAAC	GUUGUUGUCACGGUCAAAC		[1321-1339]
					22	UCGACAACCUGAUGCAGCA	UGCUGCAUCAGGUUGUCGA		[777-795]
23	GGUUCUCUGUCCUACCUGA	UCAGGUAGGACAGAGAACC		[902-920]
					24	AAUGGUACCUCGUUUGACA	UGUCAAACGAGGUACCAUU		[533-551]
25	AGUCCAGCACCUACGUGAA	UUCACGUAGGUGCUGGACU		[513-531]
					26	AGAACAUCUUCUCCUUCUA	UAGAAGGAGAAGAUGUUCU	大鼠，Ms	[810-828]
27	AGGUGCUCAAGAACUACAU	AUGUAGUUCUUGAGCACCU		[339-357]
					28	UGAGCUGGAAGGAGUGAGA	UCUCACUCCUUCCAGCUCA		[1898-1916]
29	GCUUCACAGUCGUCUUCGA	UCGAAGACGACUGUGAAGC		[405-423]
					30	GCUUCAUGGGCAUGGACAU	AUGUCCAUGCCCAUGAAGC		[1239-1257]
31	GUGUUUGACCGUGACAACA	UGUUGUCACGGUCAAACAC		[1319-1337]
					32	UGCUCAAGAACUACAUGGA	UCCAUGUAGUUCUUGAGCA		[342-360]
33	GAGGUGCUCAAGAACUACA	UGUAGUUCUUGAGCACCUC		[338-356]
					34	GAGGCAAAGGCUACAAGCU	AGCUUGUAGCCUUUGCCUC		[1161-1179]
35	GUGUCAAAGUGGAGAGGCA	UGCCUCUCCACUUUGACAC		[645-663]
					36	UUCCCGAGGUGCUCAAGAA	UUCUUGAGCACCUCGGGAA		[333-351]
37	GCAUCUCCGUCAACAACGU	ACGUUGUUGACGGAGAUGC		[747-765]
					38	AGGACUACACGCUCAAGGU	ACCUUGAGCGUGUAGUCCU		[1188-1206]
39	ACAUGGAAAUACAGUUGUU	AACAACUGUAUUUCCAUGU		[2084-2102]
					40	GGACAAAACCCACCUUGUU	AACAAGGUGGGUUUUGUCC		[1919-1937]
41	GGCAAAGGCUACAAGCUGU	ACAGCUUGUAGCCUUUGCC		[1163-1181]
					42	UGCACAAGUUCACGUCCAU	AUGGACGUGAACUUGUGCA		[210-228]
43	CGACUUGCUGUUUUGUUCU	AGAACAAAACAGCAAGUCG		[1515-1533]
					44	GCUGAUCCAGAGCACAGAU	AUCUGUGCUCUGGAUCAGC		[1606-1624]
45	CUCUGUGGAGGACCUGAUU	AAUCAGGUCCUCCACAGAG		[256-274]

46	CGAGGUGCUCAAGAACUAC	GUAGUUCUUGAGCACCUCG		[337-355]
					47	ACUACAUGGACGCCCAGUA	UACUGGGCGUCCAUGUAGU		[351-369]
48	AGCUGAUCCAGAGCACAGA	UCUGUGCUCUGGAUCAGCU		[1605-1623]
					49	AGCUGGUGGACCAGAACAU	AUGUUCUGGUCCACCAGCU		[798-816]
50	GUACCUCGUUUGACAUCCA	UGGAUGUCAAACGAGGUAC		[537-555]
					51	GUUCUCUGUCCUACCUGAA	UUCAGGUAGGACAGAGAAC		[903-921]
52	GCUGUUUUGUUCUGUGGUU	AACCACAGAACAAAACAGC		[1521-1539]
					53	ACAAGUACAACAGCGACAA	UUGUCGCUGUUGUACUUGU		[495-513]
54	ACUGCAAACUGCUGGACAU	AUGUCCAGCAGUUUGCAGU		[459-477]
					55	CCCGACUUGCUGUUUUGUU	AACAAAACAGCAAGUCGGG		[1513-1531]
56	CACAGAUCUGUUUCGUGCA	UGCACGAAACAGAUCUGUG		[1618-1636]
					57	UGAUUCAGGGCGAGUACAU	AUGUACUCGCCCUGAAUCA		[1092-1110]
58	GAAACAGAGGAGAGUCCCA	UGGGACUCUCCUCUGUUUC		[1400-1418]
					59	CAAGUACAACAGCGACAAG	CUUGUCGCUGUUGUACUUG		[496-514]
60	CUGUCCUACCUGAAUGUCA	UGACAUUCAGGUAGGACAG		[908-926]
					61	UGGGAGGCAAAGGCUACAA	UUGUAGCCUUUGCCUCCCA		[1158-1176]
62	UGGUGGACCAGAACAUCUU	AAGAUGUUCUGGUCCACCA		[801-819]
					63	GGGACAAAACCCACCUUGU	ACAAGGUGGGUUUUGUCCC		[1918-1936]
64	GAAGAAUGGUACCUCGUUU	AAACGAGGUACCAUUCUUC		[529-547]
					65	CCCAGCUGACAUGGAAAUA	UAUUUCCAUGUCAGCUGGG		[2076-2094]
66	CCAGCACAGAAACAGAGGA	UCCUCUGUUUCUGUGCUGG		[1392-1410]
					67	UGAGGAUGAGCUGGAAGGA	UCCUUCCAGCUCAUCCUCA		[1892-1910]
68	CCUCCCUGGGUUCAGAAAU	AUUUCUGAACCCAGGGAGG		[1544-1562]
					69	GCUCAAGAACUACAUGGAC	GUCCAUGUAGUUCUUGAGC		[343-361]
70	ACCAGAACAUCUUCUCCUU	AAGGAGAAGAUGUUCUGGU		[807-825]
					71	AGAGCUGAUCCAGAGCACA	UGUGCUCUGGAUCAGCUCU		[1603-1621]
72	CUGAUUCAGGGCGAGUACA	UGUACUCGCCCUGAAUCAG		[1091-1109]

73	CUGCACAAGUUCACGUCCA	UGGACGUGAACUUGUGCAG		[209-227]
					74	AACAGAGGAGAGUCCCAGA	UCUGGGACUCUCCUCUGUU		[1402-1420]
75	AGGCAUCACCUUCAUCGCA	UGCGAUGAAGGUGAUGCCU		[691-709]
					76	CCCUGGGUUCAGAAAUGCU	AGCAUUUCUGAACCCAGGG		[1547-1565]
77	ACCUGAUGCAGCAGAAGCU	AGCUUCUGCUGCAUCAGGU		[783-801]
					78	CGUGAAGAAUGGUACCUCG	CGAGGUACCAUUCUUCACG		[526-544]
79	AAGUGGAGAGGCAGGUCUU	AAGACCUGCCUCUCCACUU		[651-669]
					80	CACCCUACCUGUUCAGUGU	ACACUGAACAGGUAGGGUG		[1839-1857]
81	CCGUCUCAAAGUACUCCCA	UGGGAGUACUUUGAGACGG		[285-303]
					82	ACAGACUCCAAGUAUUACA	UGUAAUACUUGGAGUCUGU		[881-899]
83	CGUCUUCGACAACCUGAUG	CAUCAGGUUGUCGAAGACG		[772-790]
					84	GCCCGACUUGCUGUUUUGU	ACAAAACAGCAAGUCGGGC		[1512-1530]
85	CCGACUUGCUGUUUUGUUC	GAACAAAACAGCAAGUCGG		[1514-1532]
					86	AGCCCGACUUGCUGUUUUG	CAAAACAGCAAGUCGGGCU		[1511-1529]
87	CACAAGUACAACAGCGACA	UGUCGCUGUUGUACUUGUG		[494-512]
					88	AGCUGACAUGGAAAUACAG	CUGUAUUUCCAUGUCAGCU		[2079-2097]
89	UGGAUCCACCACAAGUACA	UGUACUUGUGGUGGAUCCA		[485-503]
					90	CCUCCAUCCACUGCAAACU	AGUUUGCAGUGGAUGGAGG		[450-468]
91	CUGACAUGGAAAUACAGUU	AACUGUAUUUCCAUGUCAG		[2081-2099]
					92	GCACCUACGUGAAGAAUGG	CCAUUCUUCACGUAGGUGC		[519-537]
93	GGUGCUCAAGAACUACAUG	CAUGUAGUUCUUGAGCACC		[340-358]
					94	UCUUCAUCGGCCGCUACUA	UAGUAGCGGCCGAUGAAGA		[1296-1314]
95	UGUCCUACCUGAAUGUCAC	GUGACAUUCAGGUAGGACA		[909-927]
					96	CUCCCUGGGUUCAGAAAUG	CAUUUCUGAACCCAGGGAG		[1545-1563]
97	CAAACUGCUGGACAUCGCU	AGCGAUGUCCAGCAGUUUG		[463-481]
					98	CAAAACCCACCUUGUUGGA	UCCAACAAGGUGGGUUUUG		[1922-1940]
99	CCAUCCACUGCAAACUGCU	AGCAGUUUGCAGUGGAUGG		[453-471]

100	AUUCAGGGCGAGUACAUGA	UCAUGUACUCGCCCUGAAU		[1094-1112]
					101	UUUGACCGUGACAACAACA	UGUUGUUGUCACGGUCAAA		[1322-1340]
102	AGUGGAGAGGCAGGUCUUU	AAAGACCUGCCUCUCCACU		[652-670]
					103	CUGGAUCCACCACAAGUAC	GUACUUGUGGUGGAUCCAG		[484-502]
104	CUCGUUUGACAUCCACUAU	AUAGUGGAUGUCAAACGAG		[541-559]
					105	GUCUGUCUCUCCAUCUGUU	AACAGAUGGAGAGACAGAC		[1574-1592]
106	ACAAGGGUUCUCUGUCCUA	UAGGACAGAGAACCCUUGU		[897-915]
					107	UCUUCGACAACCUGAUGCA	UGCAUCAGGUUGUCGAAGA		[774-792]
108	CAACCUGAUGCAGCAGAAG	CUUCUGCUGCAUCAGGUUG		[781-799]
					109	CCAGAGCACAGAUCUGUUU	AAACAGAUCUGUGCUCUGG		[1612-1630]
110	CACUGCAAACUGCUGGACA	UGUCCAGCAGUUUGCAGUG		[458-476]
					111	UGCUGGAUCCACCACAAGU	ACUUGUGGUGGAUCCAGCA		[482-500]
112	CUCCAAGUAUUACAAGGGU	ACCCUUGUAAUACUUGGAG		[886-904]
					113	AGGAUGAGCUGGAAGGAGU	ACUCCUUCCAGCUCAUCCU		[1894-1912]
114	AGUGCUUCACAGUCGUCUU	AAGACGACUGUGAAGCACU		[402-420]
					115	AUCUGUUUCGUGCAUUGGA	UCCAAUGCACGAAACAGAU		[1623-1641]
116	ACCACAAGUACAACAGCGA	UCGCUGUUGUACUUGUGGU		[492-510]
					117	CCACAAGUACAACAGCGAC	GUCGCUGUUGUACUUGUGG		[493-511]
118	AAGCCCGACUUGCUGUUUU	AAAACAGCAAGUCGGGCUU		[1510-1528]
					119	CUGGUGGACCAGAACAUCU	AGAUGUUCUGGUCCACCAG		[800-818]
120	AGAAUGGUACCUCGUUUGA	UCAAACGAGGUACCAUUCU		[531-549]
					121	AGAGGACUACACGCUCAAG	CUUGAGCGUGUAGUCCUCU		[1186-1204]
122	GAUUCAGGGCGAGUACAUG	CAUGUACUCGCCCUGAAUC		[1093-1111]
					123	UGAAGAAUGGUACCUCGUU	AACGAGGUACCAUUCUUCA		[528-546]
124	ACAGAUCUGUUUCGUGCAU	AUGCACGAAACAGAUCUGU		[1619-1637]
					125	GACAACCUGAUGCAGCAGA	UCUGCUGCAUCAGGUUGUC		[779-797]
126	UGAUGCAGCAGAAGCUGGU	ACCAGCUUCUGCUGCAUCA		[786-804]

127	CUCUGUCCUACCUGAAUGU	ACAUUCAGGUAGGACAGAG		[906-924]
					128	CCACCACAAGUACAACAGC	GCUGUUGUACUUGUGGUGG		[490-508]
129	GCUGACAUGGAAAUACAGU	ACUGUAUUUCCAUGUCAGC		[2080-2098]
					130	AAGCUGGUGGACCAGAACA	UGUUCUGGUCCACCAGCUU		[797-815]
131	GGUGGACCAGAACAUCUUC	GAAGAUGUUCUGGUCCACC		[802-820]
					132	GCACAGAAACAGAGGAGAG	CUCUCCUCUGUUUCUGUGC		[1395-1413]
133	GAUCCACCACAAGUACAAC	GUUGUACUUGUGGUGGAUC		[487-505]
					134	GACUACACGCUCAAGGUGU	ACACCUUGAGCGUGUAGUC		[1190-1208]
135	UCCAGAGCACAGAUCUGUU	AACAGAUCUGUGCUCUGGA		[1611-1629]
					136	GAUCCAGAGCACAGAUCUG	CAGAUCUGUGCUCUGGAUC		[1609-1627]
137	CAGCACCUACGUGAAGAAU	AUUCUUCACGUAGGUGCUG		[517-535]
					138	UGUUUUGUUCUGUGGUUUU	AAAACCACAGAACAAAACA		[1523-1541]
139	AGGCAAAGGCUACAAGCUG	CAGCUUGUAGCCUUUGCCU		[1162-1180]
					140	AUGGUACCUCGUUUGACAU	AUGUCAAACGAGGUACCAU		[534-552]
141	CAGAACAUCUUCUCCUUCU	AGAAGGAGAAGAUGUUCUG		[809-827]
					142	GAGCACAGAUCUGUUUCGU	ACGAAACAGAUCUGUGCUC		[1615-1633]
143	AGGGUUCUCUGUCCUACCU	AGGUAGGACAGAGAACCCU		[900-918]
					144	CAAGUAUUACAAGGGUUCU	AGAACCCUUGUAAUACUUG		[889-907]
145	CUGUUUUGUUCUGUGGUUU	AAACCACAGAACAAAACAG		[1522-1540]
					146	UUCAUCGGCCGCUACUACA	UGUAGUAGCGGCCGAUGAA		[1298-1316]
147	UGCCUGUCUGUCUCUCCAU	AUGGAGAGACAGACAGGCA		[1569-1587]
					148	AUCCACCACAAGUACAACA	UGUUGUACUUGUGGUGGAU		[488-506]
149	AGCACAGAAACAGAGGAGA	UCUCCUCUGUUUCUGUGCU		[1394-1412]
					150	UGACCGUGACAACAACAGG	CCUGUUGUUGUCACGGUCA		[1324-1342]
151	CUUGCUGUUUUGUUCUGUG	CACAGAACAAAACAGCAAG		[1518-1536]
					152	AGAUCUGUUUCGUGCAUUG	CAAUGCACGAAACAGAUCU		[1621-1639]
153	GAUCACACUGAAGCUGGGA	UCCCAGCUUCAGUGUGAUC		[1144-1162]

154	AAGUCCAGCACCUACGUGA	UCACGUAGGUGCUGGACUU		[512-530]
					155	CGUUUGACAUCCACUAUGG	CCAUAGUGGAUGUCAAACG		[543-561]
156	GAUGAGCUGGAAGGAGUGA	UCACUCCUUCCAGCUCAUC		[1896-1914]
					157	GACAUGGAAAUACAGUUGU	ACAACUGUAUUUCCAUGUC		[2083-2101]
158	ACAACAACAGGGUGGGCUU	AAGCCCACCCUGUUGUUGU		[1332-1350]
					159	UUCAGGGCGAGUACAUGAU	AUCAUGUACUCGCCCUGAA		[1095-1113]
160	GAAUGGUACCUCGUUUGAC	GUCAAACGAGGUACCAUUC		[532-550]
					161	ACAUCUUCUCCUUCUACCU	AGGUAGAAGGAGAAGAUGU	大鼠，Ms	[813-831]
162	CAAGGGUUCUCUGUCCUAC	GUAGGACAGAGAACCCUUG		[898-916]
					163	UCCACUGCAAACUGCUGGA	UCCAGCAGUUUGCAGUGGA		[456-474]
164	ACCUACGUGAAGAAUGGUA	UACCAUUCUUCACGUAGGU		[521-539]
					165	UGCUGUUUUGUUCUGUGGU	ACCACAGAACAAAACAGCA		[1520-1538]
166	CUGUUUCGUGCAUUGGAAG	CUUCCAAUGCACGAAACAG		[1625-1643]
					167	CACCUACGUGAAGAAUGGU	ACCAUUCUUCACGUAGGUG		[520-538]
168	AUCUUCUCCUUCUACCUGA	UCAGGUAGAAGGAGAAGAU	大鼠，Ms	[815-833]
					169	GACCAGAACAUCUUCUCCU	AGGAGAAGAUGUUCUGGUC		[806-824]
170	GUAUUACAAGGGUUCUCUG	CAGAGAACCCUUGUAAUAC		[892-910]
					171	UUCUCUGUCCUACCUGAAU	AUUCAGGUAGGACAGAGAA		[904-922]
172	UGUUUCGUGCAUUGGAAGA	UCUUCCAAUGCACGAAACA		[1626-1644]
					173	CCUGGGUUCAGAAAUGCUG	CAGCAUUUCUGAACCCAGG		[1548-1566]
174	UCUGCAGCUGACCUCUGUU	AACAGAGGUCAGCUGCAGA		[2032-2050]
					175	UGGACAUCGCUUGCUGGAU	AUCCAGCAAGCGAUGUCCA		[471-489]
176	CUACGUGAAGAAUGGUACC	GGUACCAUUCUUCACGUAG		[523-541]
					177	AGAAAUGCUGCCUGCCUGU	ACAGGCAGGCAGCAUUUCU		[1557-1575]
178	UUGCUGGAUCCACCACAAG	CUUGUGGUGGAUCCAGCAA		[481-499]
					179	CCAGCUGACAUGGAAAUAC	GUAUUUCCAUGUCAGCUGG		[2077-2095]
180	CACAGACUCCAAGUAUUAC	GUAAUACUUGGAGUCUGUG		[880-898]

181	CCUACGUGAAGAAUGGUAC	GUACCAUUCUUCACGUAGG		[522-540]
					182	GACUUGCUGUUUUGUUCUG	CAGAACAAAACAGCAAGUC		[1516-1534]
183	GACUCCAAGUAUUACAAGG	CCUUGUAAUACUUGGAGUC		[884-902]
					184	GGACCAGAACAUCUUCUCC	GGAGAAGAUGUUCUGGUCC		[805-823]
185	GUAGAGCUGAUCCAGAGCA	UGCUCUGGAUCAGCUCUAC		[1601-1619]
					186	CUGUCUGUCUCUCCAUCUG	CAGAUGGAGAGACAGACAG		[1572-1590]
187	CAGAUCUGUUUCGUGCAUU	AAUGCACGAAACAGAUCUG		[1620-1638]
					188	UGAUCCAGAGCACAGAUCU	AGAUCUGUGCUCUGGAUCA		[1608-1626]
189	CAUGGAAAUACAGUUGUUG	CAACAACUGUAUUUCCAUG		[2085-2103]
					190	ACAAGUCCAGCACCUACGU	ACGUAGGUGCUGGACUUGU		[510-528]
191	AGUACAACAGCGACAAGUC	GACUUGUCGCUGUUGUACU		[498-516]
					192	AUCCCGCUGCACAAGUUCA	UGAACUUGUGCAGCGGGAU		[203-221]
193	UACCUGAAUGUCACCCGCA	UGCGGGUGACAUUCAGGUA		[914-932]
					194	ACAUCGCUUGCUGGAUCCA	UGGAUCCAGCAAGCGAUGU		[474-492]
195	CACCACAAGUACAACAGCG	CGCUGUUGUACUUGUGGUG		[491-509]
					196	ACAACAGCGACAAGUCCAG	CUGGACUUGUCGCUGUUGU		[501-519]
197	CUUCGACAACCUGAUGCAG	CUGCAUCAGGUUGUCGAAG		[775-793]
					198	GUGAAGAAUGGUACCUCGU	ACGAGGUACCAUUCUUCAC		[527-545]
199	AGACUCCAAGUAUUACAAG	CUUGUAAUACUUGGAGUCU		[883-901]
					200	GAACAUCUUCUCCUUCUAC	GUAGAAGGAGAAGAUGUUC	大鼠，Ms	[811-829]
201	AGCUGACCUCUGUUGUCCU	AGGACAACAGAGGUCAGCU		[2037-2055]
					202	CUGGGUUCAGAAAUGCUGC	GCAGCAUUUCUGAACCCAG		[1549-1567]
203	ACUACACGCUCAAGGUGUC	GACACCUUGAGCGUGUAGU		[1191-1209]
					204	CACAGAAACAGAGGAGAGU	ACUCUCCUCUGUUUCUGUG		[1396-1414]
205	CUCCAUCCACUGCAAACUG	CAGUUUGCAGUGGAUGGAG		[451-469]
					206	UCUUCUCCUUCUACCUGAG	CUCAGGUAGAAGGAGAAGA		[816-834]
207	AUUCCCGAGGUGCUCAAGA	UCUUGAGCACCUCGGGAAU		[332-350]

208	CCUGUCUGUCUCUCCAUCU	AGAUGGAGAGACAGACAGG		[1571-1589]
					209	CAUCCACUGCAAACUGCUG	CAGCAGUUUGCAGUGGAUG		[454-472]
210	UAGAGCUGAUCCAGAGCAC	GUGCUCUGGAUCAGCUCUA		[1602-1620]
					211	CAGCACAGAAACAGAGGAG	CUCCUCUGUUUCUGUGCUG		[1393-1411]
212	ACCGUGACAACAACAGGGU	ACCCUGUUGUUGUCACGGU		[1326-1344]
					213	GCACAAGUUCACGUCCAUC	GAUGGACGUGAACUUGUGC		[211-229]
214	UUCACAGUCGUCUUCGACA	UGUCGAAGACGACUGUGAA		[407-425]
					215	AAGUACAACAGCGACAAGU	ACUUGUCGCUGUUGUACUU		[497-515]
216	CUCAAGAACUACAUGGACG	CGUCCAUGUAGUUCUUGAG		[344-362]
					217	ACCUCGUUUGACAUCCACU	AGUGGAUGUCAAACGAGGU		[539-557]
218	UACAACAGCGACAAGUCCA	UGGACUUGUCGCUGUUGUA		[500-518]
					219	CAAGCCCGACUUGCUGUUU	AAACAGCAAGUCGGGCUUG		[1509-1527]
220	GCAAAGGCUACAAGCUGUC	GACAGCUUGUAGCCUUUGC		[1164-1182]
					221	UACAUGGACGCCCAGUACU	AGUACUGGGCGUCCAUGUA		[353-371]
222	UCUCCGUCAACAACGUGCU	AGCACGUUGUUGACGGAGA		[750-768]
					223	AGAGCACAGAUCUGUUUCG	CGAAACAGAUCUGUGCUCU		[1614-1632]
224	UCUCCUUCUACCUGAGCAG	CUGCUCAGGUAGAAGGAGA		[819-837]
					225	UCCAAGUAUUACAAGGGUU	AACCCUUGUAAUACUUGGA		[887-905]
226	AAGGGUUCUCUGUCCUACC	GGUAGGACAGAGAACCCUU		[899-917]
					227	CGUCUCAAAGUACUCCCAG	CUGGGAGUACUUUGAGACG		[286-304]
228	GUGGACCAGAACAUCUUCU	AGAAGAUGUUCUGGUCCAC		[803-821]
					229	AACAGCGACAAGUCCAGCA	UGCUGGACUUGUCGCUGUU		[503-521]
230	UGACAUGGAAAUACAGUUG	CAACUGUAUUUCCAUGUCA		[2082-2100]
					231	ACUUGCUGUUUUGUUCUGU	ACAGAACAAAACAGCAAGU		[1517-1535]
232	UCCAGCACCUACGUGAAGA	UCUUCACGUAGGUGCUGGA		[515-533]
					233	UCACAGUCGUCUUCGACAC	GUGUCGAAGACGACUGUGA		[408-426]
234	CCAAGUAUUACAAGGGUUC	GAACCCUUGUAAUACUUGG		[888-906]

235	GUCUCUCCAUCUGUUUGGU	ACCAAACAGAUGGAGAGAC		[1578-1596]
					236	AGCACAGAUCUGUUUCGUG	CACGAAACAGAUCUGUGCU		[1616-1634]
237	UCCACCACAAGUACAACAG	CUGUUGUACUUGUGGUGGA	大鼠	[489-507]
					238	UCAAGAACUACAUGGACGC	GCGUCCAUGUAGUUCUUGA		[345-363]
239	CAUCUCCGUCAACAACGUG	CACGUUGUUGACGGAGAUG		[748-766]
					240	UGUCUGUCUCUCCAUCUGU	ACAGAUGGAGAGACAGACA		[1573-1591]
241	UUCUCCUUCUACCUGAGCA	UGCUCAGGUAGAAGGAGAA		[818-836]
					242	CCAGAACAUCUUCUCCUUC	GAAGGAGAAGAUGUUCUGG		[808-826]
243	GCACAGAUCUGUUUCGUGC	GCACGAAACAGAUCUGUGC		[1617-1635]
					244	AAAGUGGAGAGGCAGGUCU	AGACCUGCCUCUCCACUUU		[650-668]
245	UGCAGCUGACCUCUGUUGU	ACAACAGAGGUCAGCUGCA		[2034-2052]
					246	AAAUGCUGCCUGCCUGUCU	AGACAGGCAGGCAGCAUUU		[1559-1577]
247	AUGGAAAUACAGUUGUUGG	CCAACAACUGUAUUUCCAU		[2086-2104]
					248	UCAGAAAUGCUGCCUGCCU	AGGCAGGCAGCAUUUCUGA		[1555-1573]
249	UCUGUCUCUCCAUCUGUUU	AAACAGAUGGAGAGACAGA		[1575-1593]
					250	GUACAACAGCGACAAGUCC	GGACUUGUCGCUGUUGUAC		[499-517]
251	GGUUCAGAAAUGCUGCCUG	CAGGCAGCAUUUCUGAACC		[1552-1570]
					252	GACAAAACCCACCUUGUUG	CAACAAGGUGGGUUUUGUC		[1920-1938]
253	UUGACCGUGACAACAACAG	CUGUUGUUGUCACGGUCAA		[1323-1341]
					254	AGUAUUACAAGGGUUCUCU	AGAGAACCCUUGUAAUACU		[891-909]
255	UAUUACAAGGGUUCUCUGU	ACAGAGAACCCUUGUAAUA		[893-911]
					256	ACAAGUUCACGUCCAUCCG	CGGAUGGACGUGAACUUGU		[213-231]
257	GUGCUCAAGAACUACAUGG	CCAUGUAGUUCUUGAGCAC		[341-359]
					258	CAGUGCUUCACAGUCGUCU	AGACGACUGUGAAGCACUG		[401-419]
259	AAACUGCUGGACAUCGCUU	AAGCGAUGUCCAGCAGUUU		[464-482]
					260	GUCCUACCUGAAUGUCACC	GGUGACAUUCAGGUAGGAC		[910-928]
261	GUCUCAAAGUACUCCCAGG	CCUGGGAGUACUUUGAGAC		[287-305]

262	CAAGAACUACAUGGACGCC	GGCGUCCAUGUAGUUCUUG		[346-364]
					263	AACUACAUGGACGCCCAGU	ACUGGGCGUCCAUGUAGUU		[350-368]
264	CAGAGCACAGAUCUGUUUC	GAAACAGAUCUGUGCUCUG		[1613-1631]
					265	UGUCAAAGUGGAGAGGCAG	CUGCCUCUCCACUUUGACA		[646-664]
266	GUUCAGAAAUGCUGCCUGC	GCAGGCAGCAUUUCUGAAC		[1553-1571]
					267	UCAGGGCGAGUACAUGAUC	GAUCAUGUACUCGCCCUGA		[1096-1114]
268	UCUCUGUCCUACCUGAAUG	CAUUCAGGUAGGACAGAGA		[905-923]
					269	UGGACCAGAACAUCUUCUC	GAGAAGAUGUUCUGGUCCA		[804-822]
270	UACAAGGGUUCUCUGUCCU	AGGACAGAGAACCCUUGUA		[896-914]
					271	CAGAAACAGAGGAGAGUCC	GGACUCUCCUCUGUUUCUG		[1398-1416]
272	UCAAAGUGGAGAGGCAGGU	ACCUGCCUCUCCACUUUGA		[648-666]
					273	CUUCAUGGGCAUGGACAUC	GAUGUCCAUGCCCAUGAAG		[1240-1258]
274	CUGCAAACUGCUGGACAU	GAUGUCCAGCAGUUUGCAG		[460-478]
					275	AGCACCUACGUGAAGAAUG	CAUUCUUCACGUAGGUGCU		[518-536]
276	AAGAAUGGUACCUCGUUUG	CAAACGAGGUACCAUUCUU		[530-548]
					277	UACCUCGUUUGACAUCCAC	GUGGAUGUCAAACGAGGUA		[538-556]
278	CUUCACAGUCGUCUUCGAC	GUCGAAGACGACUGUGAAG		[406-424]
					279	ACUCCAAGUAUUACAAGGG	CCCUUGUAAUACUUGGAGU		[885-903]
280	CUGUCUCUCCAUCUGUUUG	CAAACAGAUGGAGAGACAG		[1576-1594]
					281	CAUCUUCUCCUUCUACCUG	CAGGUAGAAGGAGAAGAUG	大鼠，Ms	[814-832]
282	GGGUUCAGAAAUGCUGCCU	AGGCAGCAUUUCUGAACCC		[1551-1569]
					283	GUUUUGUUCUGUGGUUUUC	GAAAACCACAGAACAAAAC		[1524-1542]
284	CACAAGUUCACGUCCAUCC	GGAUGGACGUGAACUUGUG		[212-230]
					285	UCGUUUGACAUCCACUAUG	CAUAGUGGAUGUCAAACGA		[542-560]
286	UUGCUGUUUUGUUCUGUGG	CCACAGAACAAAACAGCAA		[1519-1537]
					287	UUUGUUCUGUGGUUUUCCC	GGGAAAACCACAGAACAAA		[1526-1544]
288	AACCUGAUGCAGCAGAAGC	GCUUCUGCUGCAUCAGGUU		[782-800]

289	AAACAGAGGAGAGUCCCAG	CUGGGACUCUCCUCUGUUU		[1401-1419]
					290	GAUCUGUUUCGUGCAUUGG	CCAAUGCACGAAACAGAUC		[1622-1640]
291	GUGCUUCACAGUCGUCUUC	GAAGACGACUGUGAAGCAC		[403-421]
					292	CAAAGGCUACAAGCUGUCC	GGACAGCUUGUAGCCUUUG		[1165-1183]
293	AAGUAUUACAAGGGUUCUC	GAGAACCCUUGUAAUACUU		[890-908]
					294	UCCCUGGGUUCAGAAAUGC	GCAUUUCUGAACCCAGGGA		[1546-1564]
295	AUCCAGAGCACAGAUCUGU	ACAGAUCUGUGCUCUGGAU		[1610-1628]
					296	ACGUGAAGAAUGGUACCUC	GAGGUACCAUUCUUCACGU		[525-543]
297	UUACAAGGGUUCUCUGUCC	GGACAGAGAACCCUUGUAA		[895-913]
					298	GUUUCGUGCAUUGGAAGAC	GUCUUCCAAUGCACGAAAC		[1627-1645]
299	AUGAGCUGGAAGGAGUGAG	CUCACUCCUUCCAGCUCAU		[1897-1915]
					300	ACAAAACCCACCUUGUUGG	CCAACAAGGUGGGUUUUGU		[1921-1939]
301	CUGAUCCAGAGCACAGAUC	GAUCUGUGCUCUGGAUCAG		[1607-1625]
					302	UGGGUUCAGAAAUGCUGCC	GGCAGCAUUUCUGAACCCA		[1550-1568]
303	UCUGUGGAGGACCUGAUUG	CAAUCAGGUCCUCCACAGA		[257-275]
					304	UCCAUCCACUGCAAACUGC	GCAGUUUGCAGUGGAUGGA		[452-470]
305	AACAUCUUCUCCUUCUACC	GGUAGAAGGAGAAGAUGUU	大鼠，Ms	[812-830]
					306	GGUACCUCGUUUGACAUCC	GGAUGUCAAACGAGGUACC		[536-554]
307	UGGUACCUCGUUUGACAUC	GAUGUCAAACGAGGUACCA		[535-553]
					308	AAACCCACCUUGUUGGAGC	GCUCCAACAAGGUGGGUUU		[1924-1942]
309	AAAGGCUACAAGCUGUCCC	GGGACAGCUUGUAGCCUUU		[1166-1184]
					310	AUUACAAGGGUUCUCUGUC	GACAGAGAACCCUUGUAAU		[894-912]
311	ACAGAAACAGAGGAGAGUC	GACUCUCCUCUGUUUCUGU		[1397-1415]
					312	UACGUGAAGAAUGGUACCU	AGGUACCAUUCUUCACGUA		[524-542]
313	AUCACACUGAAGCUGGGAG	CUCCCAGCUUCAGUGUGAU		[1145-1163]
					314	AACUGCUGGACAUCGCUUG	CAAGCGAUGUCCAGCAGUU		[465-483]
315	GUCUUCGACAACCUGAUGC	GCAUCAGGUUGUCGAAGAC		[773-791]

316	UUUCGUGCAUUGGAAGACC	GGUCUUCCAAUGCACGAAA		[1628-1646]
					317	ACCCUACCUGUUCAGUGUC	GACACUGAACAGGUAGGGU		[1840-1858]
318	UGUCUCUCCAUCUGUUUGG	CCAAACAGAUGGAGAGACA		[1577-1595]
					319	UUUUGUUCUGUGGUUUUCC	GGAAAACCACAGAACAAAA		[1525-1543]
320	UUCGACAACCUGAUGCAGC	GCUGCAUCAGGUUGUCGAA		[776-794]
					321	AGAAACAGAGGAGAGUCCC	GGGACUCUCCUCUGUUUCU		[1399-1417]
322	CUUCUCCUUCUACCUGAGC	GCUCAGGUAGAAGGAGAAG		[817-835]
					323	CUCUCCAUCUGUUUGGUGG	CCACCAAACAGAUGGAGAG		[1580-1598]
324	UUCGUGCAUUGGAAGACCC	GGGUCUUCCAAUGCACGAA		[1629-1647]
					325	UGCAAACUGCUGGACAUCG	CGAUGUCCAGCAGUUUGCA		[461-479]
326	AAAACCCACCUUGUUGGAG	CUCCAACAAGGUGGGUUUU		[1923-1941]
					327	AUCUCCGUCAACAACGUGC	GCACGUUGUUGACGGAGAU		[749-767]
328	UCUCCAUCUGUUUGGUGGG	CCCACCAAACAGAUGGAGA		[1581-1599]
					329	AAGAACUACAUGGACGCCC	GGGCGUCCAUGUAGUUCUU		[347-365]
330	UCUGUCCUACCUGAAUGUC	GACAUUCAGGUAGGACAGA		[907-925]
					331	UCUCAAAGUACUCCCAGGC	GCCUGGGAGUACUUUGAGA		[288-306]
332	UGCUUCACAGUCGUCUUCG	CGAAGACGACUGUGAAGCA		[404-422]
					333	UUCAGAAAUGCUGCCUGCC	GGCAGGCAGCAUUUCUGAA		[1554-1572]
334	AUCCACUGCAAACUGCUGG	CCAGCAGUUUGCAGUGGAU		[455-473]
					335	UCUCUCCAUCUGUUUGGUG	CACCAAACAGAUGGAGAGA		[1579-1597]
336	UUCAUGGGCAUGGACAUCC	GGAUGUCCAUGCCCAUGAA		[1241-1259]
					337	UCCUACCUGAAUGUCACCC	GGGUGACAUUCAGGUAGGA		[911-929]

表B 13 CYBA-细胞色素b-245，α多肽

No.	正义链siRNA	反义链siRNA	其他Sp	人-68509913：37-624
					1	CCUUUACCAGGAAUUACUA	UAGUAAUUCCUGGUAAAGG	Chmp	[281-299]
2	GGCCCUUUACCAGGAAUUA	UAAUUCCUGGUAAAGGGCC	Chmp	[278-296]
					3	AGAUCGGAGGCACCAUCAA	UUGAUGGUGCCUCCGAUCU	Mnk，Chmp	[464-482]

4	CCCUUUACCAGGAAUUACU	AGUAAUUCCUGGUAAAGGG	Chmp	[280-298]
					5	GGGCCCUUUACCAGGAAUU	AAUUCCUGGUAAAGGGCCC	Chmp	[277-295]
6	AAGCUGUUCGGGCCCUUUA	UAAAGGGCCCGAACAGCUU	Chmp	[268-286]
					7	UGCACCCACCUGCAAUAAA	UUUAUUGCAGGUGGGUGCA		[654-672]
8	GCCCUUUACCAGGAAUUAC	GUAAUUCCUGGUAAAGGGC	Chmp	[279-297]
					9	CUUUACCAGGAAUUACUAU	AUAGUAAUUCCUGGUAAAG		[282-300]
10	CACCCAGUGGUACUUUGGU	ACCAAAGUACCACUGGGUG	Chmp	[135-153]
					11	GUGCACCCACCUGCAAUAA	UUAUUGCAGGUGGGUGCAC		[653-671]
12	CAGGAAUUACUAUGUUCGG	CCGAACAUAGUAAUUCCUG		[288-306]
					13	AGUGGUACUUUGGUGCCUA	UAGGCACCAAAGUACCACU	Chmp	[140-158]
14	AGAAGUACAUGACCGCCGU	ACGGCGGUCAUGUACUUCU	Chmp	[245-263]
					15	UACCAGGAAUUACUAUGUU	AACAUAGUAAUUCCUGGUA		[285-303]
16	CUUUGGUGCCUACUCCAUU	AAUGGAGUAGGCACCAAAG	Chmp	[147-165]
					17	GGGACAGAAGUACAUGACC	GGUCAUGUACUUCUGUCCC	Mnk，Chmp	[240-258]
18	UACUUUGGUGCCUACUCCA	UGGAGUAGGCACCAAAGUA	Chmp	[145-163]
					19	GUGGUACUUUGGUGCCUAC	GUAGGCACCAAAGUACCAC	Chmp	[141-159]
20	GGACAGAAGUACAUGACCG	CGGUCAUGUACUUCUGUCC	Chmp	[241-259]
					21	CCAGGAAUUACUAUGUUCG	CGAACAUAGUAAUUCCUGG		[287-305]
22	GCUUCACCCAGUGGUACUU	AAGUACCACUGGGUGAAGC	Rb，Mnk，Chmp	[131-149]
					23	ACUUUGGUGCCUACUCCAU	AUGGAGUAGGCACCAAAGU	Chmp	[146-164]
24	UUACCAGGAAUUACUAUGU	ACAUAGUAAUUCCUGGUAA		[284-302]
					25	CAGUGGUACUUUGGUGCCU	AGGCACCAAAGUACCACUG	Chmp	[139-157]
26	ACCAGGAAUUACUAUGUUC	GAACAUAGUAAUUCCUGGU		[286-304]
					27	GGUACUUUGGUGCCUACUC	GAGUAGGCACCAAAGUACC	Chmp	[143-161]
28	GACAGAAGUACAUGACCGC	GCGGUCAUGUACUUCUGUC	Chmp	[242-260]
					29	UUUGGUGCCUACUCCAUUG	CAAUGGAGUAGGCACCAAA	Chmp	[148-166]
30	ACCCAGUGGUACUUUGGUG	CACCAAAGUACCACUGGGU	Chmp	[136-154]

31	UGGUGCCUACUCCAUUGUG	CACAAUGGAGUAGGCACCA	Chmp	[150-168]
					32	AAGAGGAAGAAGGGCUCCA	UGGAGCCCUUCUUCCUCUU	Mnk，Chmp	[208-226]
33	GAAUUACUAUGUUCGGGCC	GGCCCGAACAUAGUAAUUC		[291-309]
					34	UGGUACUUUGGUGCCUACU	AGUAGGCACCAAAGUACCA	Chmp	[142-160]
35	CUUCACCCAGUGGUACUUU	AAAGUACCACUGGGUGAAG	Mnk，Chmp	[132-150]
					36	GGAAUUACUAUGUUCGGGC	GCCCGAACAUAGUAAUUCC		[290-308]
37	GUACUUUGGUGCCUACUCC	GGAGUAGGCACCAAAGUAC	Chmp	[144-162]
					38	UCACCCAGUGGUACUUUGG	CCAAAGUACCACUGGGUGA	Mnk，Chmp	[134-152]
39	AGGAAUUACUAUGUUCGGG	CCCGAACAUAGUAAUUCCU		[289-307]
					40	UUCACCCAGUGGUACUUUG	CAAAGUACCACUGGGUGAA	Mnk，Chmp	[133-151]
41	UUGGUGCCUACUCCAUUGU	ACAAUGGAGUAGGCACCAA	Chmp	[149-167]
					42	UUUACCAGGAAUUACUAUG	CAUAGUAAUUCCUGGUAAA		[283-301]
43	AUUACUAUGUUCGGGCCGU	ACGGCCCGAACAUAGUAAU		[293-311]
					44	UUACUAUGUUCGGGCCGUC	GACGGCCCGAACAUAGUAA		[294-312]
45	ACAGAAGUACAUGACCGCC	GGCGGUCAUGUACUUCUGU	Chmp	[243-261]
					46	AAUUACUAUGUUCGGGCCG	CGGCCCGAACAUAGUAAUU		[292-310]
47	UGGGGACAGAAGUACAUGA	UCAUGUACUUCUGUCCCCA

表B 14DDIT4-DNA-损伤诱导转录体4

No.	正义链siRNA	反义链siRNA	其他Sp	人-56676369：203-901
					1	GAGGAGUGUUGAACUUCAA	UUGAAGUUCAACACUCCUC	Cyn	[890-908]
2	CAGUGACCCUGAGGAUGAA	UUCAUCCUCAGGGUCACUG	Cyn，Chmp	[454-472]
					3	CUAGAACUGUUUACAUGAA	UUCAUGUAAACAGUUCUAG	Cyn，大鼠	[1635-1653]
4	CCAGGUGGGCAAAGAACUA	UAGUUCUUUGCCCACCUGG	Cyn，Chmp	[577-595]
					5	GAUACUCACUGUUCAUGAA	UUCAUGAACAGUGAGUAUC	Cyn	[1659-1677]
6	CUGGGUCUUCCAUCUAGAA	UUCUAGAUGGAAGACCCAG	大鼠，Ms	[1622-1640]
					7	GAAUACACUUGAUGUUCAA	UUGAACAUCAAGUGUAUUC	Cyn，大鼠，Ms	[1675-1693]
8	GCUUCCGAGUCAUCAAGAA	UUCUUGAUGACUCGGAAGC	Chmp	[840-858]

9	UCCGAGUCAUCAAGAAGAA	UUCUUCUUGAUGACUCGGA	Chmp	[843-861]
					10	GCAGGACGCACUUGUCUUA	UAAGACAAGUGCGUCCUGC		[98-116]
11	GUUUGUUGUUUGUUUUGUA	UACAAAACAAACAACAAAC		[1365-1383]
					12	GGAUCUUUGACACUUGAAA	UUUCAAGUGUCAAAGAUCC	Cyn	[1488-1506]
13	CAGCUAUCUUACAGACGCA	UGCGUCUGUAAGAUAGCUG	Cyn	[1427-1445]
					14	AGUUAACAGUGGUGUGACA	UGUCACACCACUGUUAACU	Cyn	[1199-1217]
15	GGACGCACUUGUCUUAGCA	UGCUAAGACAAGUGCGUCC		[101-119]
					16	GGUUCGCACACCCAUUCAA	UUGAAUGGGUGUGCGAACC		[76-94]
17	ACUUGAUGUUCAAGUAUUA	UAAUACUUGAACAUCAAGU	Ms	[1681-1699]
					18	GCAUGUACCUUAUUAUUUU	AAAAUAAUAAGGUACAUGC	Cyn	[1170-1188]
19	UUUUGUUACUGACAGUUAA	UUAACUGUCAGUAACAAAA	Cyn	[1186-1204]
					20	CACUGUUCAUGAAUACACU	AGUGUAUUCAUGAACAGUG	Cyn	[1665-1683]
21	CAGUGGUGUGACAUCCAGA	UCUGGAUGUCACACCACUG		[1205-1223]
					22	CGGAACAGCUGCUCAUUGA	UCAAUGAGCAGCUGUUCCG	Cyn，Chmp	[873-891]
23	GAUUCCUGUGGUUGGAAAA	UUUUCCAACCACAGGAAUC	Cyn	[990-1008]
					24	CUCAUUGAGGAGUGUUGAA	UUCAACACUCCUCAAUGAG	Cyn	[884-902]
25	GUUCAAGUAUUAAGACCUA	UAGGUCUUAAUACUUGAAC	Ms	[1688-1706]
					26	UGAUGUUCAAGUAUUAAGA	UCUUAAUACUUGAACAUCA	Ms	[1684-1702]
27	AGAACUGUUUACAUGAAGA	UCUUCAUGUAAACAGUUCU	Cyn，大鼠	[1637-1655]
					28	CCAGGAAGCUCAUUGAGUU	AACUCAAUGAGCUUCCUGG		[1051-1069]
29	GAAGCUGUACAGCUCGGAA	UUCCGAGCUGUACAGCUUC	Cyn，Chmp	[859-877]
					30	UACUGUAGCAUGAAACAAA	UUUGUUUCAUGCUACAGUA	Cyn，大鼠，Ms，Rb	[1110-1128]
31	GAUCUUUGACACUUGAAAA	UUUUCAAGUGUCAAAGAUC	Cyn	[1489-1507]
					32	UGAGGAGUGUUGAACUUCA	UGAAGUUCAACACUCCUCA	Cyn	[889-907]
33	ACGCAUGAAUGUAAGAGUA	UACUCUUACAUUCAUGCGU	Cyn	[1441-1459]
					34	CAAGACAGAGACGACUGAA	UUCAGUCGUCUCUGUCUUG		[933-951]
35	CUGUUUACAUGAAGAUAAG	CUUAUCUUCAUGUAAACAG	Cyn	[1641-1659]

36	CUCUGAGUUCAUCAGCAAA	UUUGCUGAUGAACUCAGAG	Chmp	[162-180]
					37	CGGCACUCUGAGUUCAUCA	UGAUGAACUCAGAGUGCCG	Chmp	[157-175]
38	CACUCUGAGUUCAUCAGCA	UGCUGAUGAACUCAGAGUG	Chmp	[160-178]
					39	CCAAGACAGAGACGACUGA	UCAGUCGUCUCUGUCUUGG		[932-950]
40	CAGAGACGACUGAACUUUU	AAAAGUUCAGUCGUCUCUG		[938-956]
					41	AAACAUGUUUGUUAAAACA	UGUUUUAACAAACAUGUUU	大鼠	[1731-1749]
42	GAAUAGUGUUUCCCAGGAA	UUCCUGGGAAACACUAUUC		[1039-1057]
					43	GUAGCAUGUACCUUAUUAU	AUAAUAAGGUACAUGCUAC	Cyn	[1167-1185]
44	CAGACGCAUGAAUGUAAGA	UCUUACAUUCAUGCGUCUG	Cyn	[1438-1456]
					45	GGGAUCUUUGACACUUGAA	UUCAAGUGUCAAAGAUCCC	Cyn	[1487-1505]
46	GACAGAGACGACUGAACUU	AAGUUCAGUCGUCUCUGUC		[936-954]
					47	CCUGUGGUUGGAAAACUGA	UCAGUUUUCCAACCACAGG	Cyn	[994-1012]
48	CAUCUAGAACUGUUUACAU	AUGUAAACAGUUCUAGAUG	Cyn，大鼠	[1632-1650]
					49	GGGACUGAUUCCUGUGGUU	AACCACAGGAAUCAGUCCC	Cyn	[984-1002]
50	UCUGGGUCUUCCAUCUAGA	UCUAGAUGGAAGACCCAGA		[1621-1639]
					51	CGCACUUGUCUUAGCAGUU	AACUGCUAAGACAAGUGCG		[104-122]
52	GUUCAUGAAUACACUUGAU	AUCAAGUGUAUUCAUGAAC	Cyn，大鼠，Ms	[1669-1687]
					53	UCAGUACUGUAGCAUGAAA	UUUCAUGCUACAGUACUGA	Cyn，大鼠，Ms	[1106-1124]
54	AGACCUAUGCAAUAUUUUU	AAAAAUAUUGCAUAGGUCU	大鼠，Ms	[1700-1718]
					55	ACUGUUUACAUGAAGAUAA	UUAUCUUCAUGUAAACAGU	Cyn	[1640-1658]
56	GAACUGUUUACAUGAAGAU	AUCUUCAUGUAAACAGUUC	Cyn，大鼠	[1638-1656]
					57	GAGUCAUCAAGAAGAAGCU	AGCUUCUUCUUGAUGACUC	Cyn，Chmp	[846-864]
58	CUUGAUGUUCAAGUAUUAA	UUAAUACUUGAACAUCAAG	Ms	[1682-1700]
					59	AGUACUGUAGCAUGAAACA	UGUUUCAUGCUACAGUACU	Cyn，大鼠，Ms，Rb	[1108-1126]
60	GGGUCUUCCAUCUAGAACU	AGUUCUAGAUGGAAGACCC	Cyn，大鼠	[1624-1642]
					61	CCUCAGUACUGUAGCAUGA	UCAUGCUACAGUACUGAGG	Cyn，大鼠，Ms	[1104-1122]
62	ACUCUGAGUUCAUCAGCAA	UUGCUGAUGAACUCAGAGU	Chmp	[161-179]

63	AGUAUUAAGACCUAUGCAA	UUGCAUAGGUCUUAAUACU	Ms	[1693-1711]
					64	UCAUCAAGAAGAAGCUGUA	UACAGCUUCUUCUUGAUGA	Cyn，Rb，Chmp	[849-867]
65	CAUGUUUGUUAAAACAGUU	AACUGUUUUAACAAACAUG		[1734-1752]
					66	CAUGUACCUUAUUAUUUUU	AAAAAUAAUAAGGUACAUG	Cyn	[1171-1189]
67	CGUGUACUGCAGAGUUGAG	CUCAACUCUGCAGUACACG		[1544-1562]
					68	CUAUCUUACAGACGCAUGA	UCAUGCGUCUGUAAGAUAG	Cyn	[1430-1448]
69	CAUGAAUGUAAGAGUAGGA	UCCUACUCUUACAUUCAUG	Cyn，Ms	[1444-1462]
					70	GUGUUGAACUUCAACCUGA	UCAGGUUGAAGUUCAACAC		[895-913]
71	GUAUCUUACUGGUCUGAAG	CUUCAGACCAGUAAGAUAC	Cyn	[1335-1353]
					72	CCCUGAGGAUGAACACUUG	CAAGUGUUCAUCCUCAGGG		[460-478]
73	UAUUAAGACCUAUGCAAUA	UAUUGCAUAGGUCUUAAUA	Ms	[1695-1713]
					74	GUUGUAGGCAGCUAUCUUA	UAAGAUAGCUGCCUACAAC	Cyn	[1419-1437]
75	GCUCAUUGAGGAGUGUUGA	UCAACACUCCUCAAUGAGC	Cyn，Rb，Chmp	[883-901]
					76	AUCGGAGCAUCACUACUGA	UCAGUAGUGAUGCUCCGAU	Cyn	[1397-1415]
77	GGAGCAUCACUACUGACCU	AGGUCAGUAGUGAUGCUCC	Cyn	[1400-1418]
					78	UGGGAUCUUUGACACUUGA	UCAAGUGUCAAAGAUCCCA	Cyn	[1486-1504]
79	UGAUUCCUGUGGUUGGAAA	UUUCCAACCACAGGAAUCA	Cyn	[989-1007]
					80	GUACUGUAGCAUGAAACAA	UUGUUUCAUGCUACAGUAC	Cyn，大鼠，Ms，Rb	[1109-1127]
81	CAUGAAGAUAAGAUACUCA	UGAGUAUCUUAUCUUCAUG	Cyn	[1648-1666]
					82	CAUCGUGUACUGCAGAGUU	AACUCUGCAGUACACGAUG		[1541-1559]
83	GGCUUCCGAGUCAUCAAGA	UCUUGAUGACUCGGAAGCC	Chmp	[839-857]
					84	ACUGUAGCAUGAAACAAAG	CUUUGUUUCAUGCUACAGU	Cyn，大鼠，Ms，Rb	[1111-1129]
85	UACUCACUGUUCAUGAAUA	UAUUCAUGAACAGUGAGUA	Cyn	[1661-1679]
					86	UCUGAUCGGAGCAUCACUA	UAGUGAUGCUCCGAUCAGA	Cyn	[1393-1411]
87	GUAUUAAGACCUAUGCAAU	AUUGCAUAGGUCUUAAUAC	Ms	[1694-1712]
					88	GAUCACUUGGGAUCUUUGA	UCAAAGAUCCCAAGUGAUC	Cyn	[1479-1497]
89	ACCUAUGCAAUAUUUUUUA	UAAAAAAUAUUGCAUAGGU		[1702-1720]

90	UCUAGAACUGUUUACAUGA	UCAUGUAAACAGUUCUAGA	Cyn，大鼠	[1634-1652]
					91	CUCAGUACUGUAGCAUGAA	UUCAUGCUACAGUACUGAG	Cyn，大鼠，Ms	[1105-1123]
92	AAGUAUUAAGACCUAUGCA	UGCAUAGGUCUUAAUACUU	Ms	[1692-1710]
					93	CCAUCUAGAACUGUUUACA	UGUAAACAGUUCUAGAUGG	Cyn，大鼠	[1631-1649]
94	UGUUGAACUUCAACCUGAG	CUCAGGUUGAAGUUCAACA		[896-914]
					95	GUACCUUAUUAUUUUUGUU	AACAAAAAUAAUAAGGUAC	Cyn	[1174-1192]
96	UCGUGUACUGCAGAGUUGA	UCAACUCUGCAGUACACGA		[1543-1561]
					97	ACAUGUUUGUUAAAACAGU	ACUGUUUUAACAAACAUGU		[1733-1751]
98	CCUUAUUAUUUUUGUUACU	AGUAACAAAAAUAAUAAGG	Cyn	[1177-1195]
					99	GCAUCACUACUGACCUGUU	AACAGGUCAGUAGUGAUGC	Cyn	[1403-1421]
100	CUUCCAUCUAGAACUGUUU	AAACAGUUCUAGAUGGAAG	Cyn，大鼠	[1628-1646]
					101	CAUUGAGGAGUGUUGAACU	AGUUCAACACUCCUCAAUG	Cyn	[886-904]
102	UACAGACGCAUGAAUGUAA	UUACAUUCAUGCGUCUGUA	Cyn	[1436-1454]
					103	UGUUCAUGAAUACACUUGA	UCAAGUGUAUUCAUGAACA	Cyn	[1668-1686]
104	AUAAGAUACUCACUGUUCA	UGAACAGUGAGUAUCUUAU	Cyn	[1655-1673]
					105	CUUUGACACUUGAAAAAUU	AAUUUUUCAAGUGUCAAAG		[1492-1510]
106	AGACAGAGACGACUGAACU	AGUUCAGUCGUCUCUGUCU		[935-953]
					107	AGAUACUCACUGUUCAUGA	UCAUGAACAGUGAGUAUCU	Cyn	[1658-1676]
108	GGAAUAGUGUUUCCCAGGA	UCCUGGGAAACACUAUUCC		[1038-1056]
					109	GACCUAUGCAAUAUUUUUU	AAAAAAUAUUGCAUAGGUC		[1701-1719]
110	GACGCAUGAAUGUAAGAGU	ACUCUUACAUUCAUGCGUC	Cyn	[1440-1458]
					111	UAAGAUACUCACUGUUCAU	AUGAACAGUGAGUAUCUUA	Cyn	[1656-1674]
112	CAUGAAUACACUUGAUGUU	AACAUCAAGUGUAUUCAUG	Cyn，大鼠，Ms	[1672-1690]
					113	AACUGUUUACAUGAAGAUA	UAUCUUCAUGUAAACAGUU	Cyn，大鼠	[1639-1657]
114	AGCUGUACAGCUCGGAACA	UGUUCCGAGCUGUACAGCU	Cyn，Chmp	[861-879]
					115	CCUGAGGAUGAACACUUGU	ACAAGUGUUCAUCCUCAGG		[461-479]
116	CUGUGGUUGGAAAACUGAG	CUCAGUUUUCCAACCACAG	Cyn	[995-1013]

117	GCAGCUGCGUUUAAGCCUU	AAGGCUUAAACGCAGCUGC		[1518-1536]
					118	CCAUCUGGGUCUUCCAUCU	AGAUGGAAGACCCAGAUGG		[1618-1636]
119	UUUUCUGAUCGGAGCAUCA	UGAUGCUCCGAUCAGAAAA		[1390-1408]
					120	ACUGAUUCCUGUGGUUGGA	UCCAACCACAGGAAUCAGU	Cyn	[987-1005]
121	AGCAUGAAACAAAGGCUUA	UAAGCCUUUGUUUCAUGCU	Cyn，Ms	[1116-1134]
					122	UGUAGCAUGUACCUUAUUA	UAAUAAGGUACAUGCUACA	Cyn	[1166-1184]
123	AACAAGGCUUCCAGCUGGA	UCCAGCUGGAAGCCUUGUU		[1141-1159]
					124	ACCUGUUGUAGGCAGCUAU	AUAGCUGCCUACAACAGGU	Cyn	[1415-1433]
125	AGGUGGGCAAAGAACUACU	AGUAGUUCUUUGCCCACCU	Cyn，Chmp	[579-597]
					126	GAGUGUUGAACUUCAACCU	AGGUUGAAGUUCAACACUC	Cyn	[893-911]
127	UACACUUGAUGUUCAAGUA	UACUUGAACAUCAAGUGUA	大鼠，Ms	[1678-1696]
					128	UAGCAUGUACCUUAUUAUU	AAUAAUAAGGUACAUGCUA	Cyn	[1168-1186]
129	UGGUCUGAAGGGACCAAGU	ACUUGGUCCCUUCAGACCA	Cyn	[1344-1362]
					130	GACCUGUUGUAGGCAGCUA	UAGCUGCCUACAACAGGUC	Cyn	[1414-1432]
131	AACAGUGGUGUGACAUCCA	UGGAUGUCACACCACUGUU		[1203-1221]
					132	UAGGCAGCUAUCUUACAGA	UCUGUAAGAUAGCUGCCUA	Cyn	[1423-1441]
133	UCCGGCACUCUGAGUUCAU	AUGAACUCAGAGUGCCGGA	Chmp	[155-173]
					134	CAUCUGGGUCUUCCAUCUA	UAGAUGGAAGACCCAGAUG		[1619-1637]
135	CUGAGGGACUGAUUCCUGU	ACAGGAAUCAGUCCCUCAG	Cyn	[980-998]
					136	UUCCCAGGAAGCUCAUUGA	UCAAUGAGCUUCCUGGGAA		[1048-1066]
137	UGACACUUGAAAAAUUACA	UGUAAUUUUUCAAGUGUCA		[1495-1513]
					138	CCGAGUCAUCAAGAAGAAG	CUUCUUCUUGAUGACUCGG	Chmp	[844-862]
139	AGGAGCUGAGGGACUGAUU	AAUCAGUCCCUCAGCUCCU	Cyn	[975-993]
					140	AGACACGGCUUACCUGGAU	AUCCAGGUAAGCCGUGUCU	Chmp	[406-424]
141	AAGACACGGCUUACCUGGA	UCCAGGUAAGCCGUGUCUU	Chmp	[405-423]
					142	GUGGUGUGACAUCCAGAGA	UCUCUGGAUGUCACACCAC		[1207-1225]
143	UGUUGUAGGCAGCUAUCUU	AAGAUAGCUGCCUACAACA	Cyn	[1418-1436]

144	UAUCUUACAGACGCAUGAA	UUCAUGCGUCUGUAAGAUA	Cyn	[1431-1449]
					145	UUUACAUGAAGAUAAGAUA	UAUCUUAUCUUCAUGUAAA	Cyn	[1644-1662]
146	UUCCGAGUCAUCAAGAAGA	UCUUCUUGAUGACUCGGAA	Chmp	[842-860]
					147	UGUAGGCAGCUAUCUUACA	UGUAAGAUAGCUGCCUACA	Cyn	[1421-1439]
148	UCACUACUGACCUGUUGUA	UACAACAGGUCAGUAGUGA	Cyn	[1406-1424]
					149	ACUUCGAGCUGCUCAGUGA	UCACUGAGCAGCUCGAAGU	Cyn，Chmp	[441-459]
150	GGUCUUCCAUCUAGAACUG	CAGUUCUAGAUGGAAGACC	Cyn，大鼠	[1625-1643]
					151	GGAAGCUCAUUGAGUUGUG	CACAACUCAAUGAGCUUCC		[1054-1072]
152	UGUCAGGGAUCACUUGGGA	UCCCAAGUGAUCCCUGACA	Cyn	[1472-1490]
					153	CUCACUGUUCAUGAAUACA	UGUAUUCAUGAACAGUGAG	Cyn	[1663-1681]
154	CUUACAGACGCAUGAAUGU	ACAUUCAUGCGUCUGUAAG	Cyn	[1434-1452]
					155	CUGAUUCCUGUGGUUGGAA	UUCCAACCACAGGAAUCAG	Cyn	[988-1006]
156	UGGGUGUCAGGGAUCACUU	AAGUGAUCCCUGACACCCA	Cyn	[1468-1486]
					157	CACUUGAUGUUCAAGUAUU	AAUACUUGAACAUCAAGUG	Ms	[1680-1698]
158	UUUGACACUUGAAAAAUUA	UAAUUUUUCAAGUGUCAAA		[1493-1511]
					159	UGUUUUGUAUCUUGUUUUU	AAAAACAAGAUACAAAACA		[1375-1393]
160	CUAAUAAACAUGUUUGUUA	UAACAAACAUGUUUAUUAG	大鼠	[1726-1744]
					161	GCAUGAAACAAAGGCUUAG	CUAAGCCUUUGUUUCAUGC	Cyn，Ms	[1117-1135]
162	GUUUGUUUUGUAUCUUGUU	AACAAGAUACAAAACAAAC		[1372-1390]
					163	GUGUAGCAUGUACCUUAUU	AAUAAGGUACAUGCUACAC	Cyn	[1165-1183]
164	UGAAGAUAAGAUACUCACU	AGUGAGUAUCUUAUCUUCA	Cyn	[1650-1668]
					165	CACUUGUCUUAGCAGUUCU	AGAACUGCUAAGACAAGUG		[106-124]
166	AAGACCUAUGCAAUAUUUU	AAAAUAUUGCAUAGGUCUU	大鼠，Ms	[1699-1717]
					167	UGUUGUUUGUUUUGUAUCU	AGAUACAAAACAAACAACA		[1368-1386]
168	GGAACAGCUGCUCAUUGAG	CUCAAUGAGCAGCUGUUCC	Cyn，Chmp	[874-892]
					169	GGUGGGCAAAGAACUACUG	CAGUAGUUCUUUGCCCACC	Chmp	[580-598]
170	UGAAUACACUUGAUGUUCA	UGAACAUCAAGUGUAUUCA	Cyn，大鼠，Ms	[1674-1692]

171	GAGCAUCACUACUGACCUG	CAGGUCAGUAGUGAUGCUC	Cyn	[1401-1419]
					172	CUUUUCUAAUAAACAUGUU	AACAUGUUUAUUAGAAAAG	大鼠，Ms	[1721-1739]
173	UAAGACCUAUGCAAUAUUU	AAAUAUUGCAUAGGUCUUA	大鼠，Ms	[1698-1716]
					174	UCAGUGACCCUGAGGAUGA	UCAUCCUCAGGGUCACUGA	Cyn，Chmp	[453-471]
175	GUAGCAUGAAACAAAGGCU	AGCCUUUGUUUCAUGCUAC	Cyn，大鼠，Ms	[1114-1132]
					176	AGAGACGACUGAACUUUUG	CAAAAGUUCAGUCGUCUCU		[939-957]
177	UUCUGAUCGGAGCAUCACU	AGUGAUGCUCCGAUCAGAA	Cyn	[1392-1410]
					178	GUGUUUCCCAGGAAGCUCA	UGAGCUUCCUGGGAAACAC		[1044-1062]
179	AAGGCUUCCAGCUGGAUGU	ACAUCCAGCUGGAAGCCUU	Cyn	[1144-1162]
					180	ACAGACGCAUGAAUGUAAG	CUUACAUUCAUGCGUCUGU	Cyn	[1437-1455]
181	GUGACCCUGAGGAUGAACA	UGUUCAUCCUCAGGGUCAC	Cyn，Chmp	[456-474]
					182	CCUGUUGUAGGCAGCUAUC	GAUAGCUGCCUACAACAGG	Cyn	[1416-1434]
183	UUCCAUCUAGAACUGUUUA	UAAACAGUUCUAGAUGGAA	Cyn，大鼠	[1629-1647]
					184	UCUUGUUUUUCUGAUCGGA	UCCGAUCAGAAAAACAAGA		[1384-1402]
185	UUUGUUGUUUGUUUUGUAU	AUACAAAACAAACAACAAA		[1366-1384]
					186	UGACCCUGAGGAUGAACAC	GUGUUCAUCCUCAGGGUCA	Cyn，Chmp	[457-475]
187	AUCUUUGACACUUGAAAAA	UUUUUCAAGUGUCAAAGAU	Cyn	[1490-1508]
					188	UGUUUUUCUGAUCGGAGCA	UGCUCCGAUCAGAAAAACA		[1387-1405]
189	CCCAGGAAGCUCAUUGAGU	ACUCAAUGAGCUUCCUGGG		[1050-1068]
					190	GGAUCACUUGGGAUCUUUG	CAAAGAUCCCAAGUGAUCC	Cyn	[1478-1496]
191	GACAGUUAACAGUGGUGUG	CACACCACUGUUAACUGUC	Cyn	[1196-1214]
					192	UGUUUACAUGAAGAUAAGA	UCUUAUCUUCAUGUAAACA	Cyn	[1642-1660]
193	ACUGGUCUGAAGGGACCAA	UUGGUCCCUUCAGACCAGU	Cyn	[1342-1360]
					194	GGGAUCACUUGGGAUCUUU	AAAGAUCCCAAGUGAUCCC	Cyn	[1477-1495]
195	ACAGUUAACAGUGGUGUGA	UCACACCACUGUUAACUGU	Cyn	[1197-1215]
					196	GUUCGCACACCCAUUCAAG	CUUGAAUGGGUGUGCGAAC		[77-95]
197	UCUUCCAUCUAGAACUGUU	AACAGUUCUAGAUGGAAGA	Cyn，大鼠	[1627-1645]

198	CGCAUGAAUGUAAGAGUAG	CUACUCUUACAUUCAUGCG	Cyn	[1442-1460]
					199	GUGUGACAUCCAGAGAGCA	UGCUCUCUGGAUGUCACAC		[1210-1228]
200	GACUGAUUCCUGUGGUUGG	CCAACCACAGGAAUCAGUC	Cyn	[986-1004]
					201	AUGAAUGUAAGAGUAGGAA	UUCCUACUCUUACAUUCAU	Cyn，Ms	[1445-1463]
202	ACGCACUUGUCUUAGCAGU	ACUGCUAAGACAAGUGCGU		[103-121]
					203	UGUUUCCCAGGAAGCUCAU	AUGAGCUUCCUGGGAAACA		[1045-1063]
204	AGGAAGACACGGCUUACCU	AGGUAAGCCGUGUCUUCCU	Chmp	[402-420]
					205	GACGCACUUGUCUUAGCAG	CUGCUAAGACAAGUGCGUC		[102-120]
206	UCAUGAAUACACUUGAUGU	ACAUCAAGUGUAUUCAUGA	Cyn，大鼠，Ms	[1671-1689]
					207	UGAUCGGAGCAUCACUACU	AGUAGUGAUGCUCCGAUCA	Cyn	[1395-1413]
208	GAUGUUCAAGUAUUAAGAC	GUCUUAAUACUUGAACAUC	Ms	[1685-1703]
					209	CAGUUAACAGUGGUGUGAC	GUCACACCACUGUUAACUG	Cyn	[1198-1216]
210	UCAAGAAGAAGCUGUACAG	CUGUACAGCUUCUUCUUGA	Cyn，Rb，Chmp	[852-870]
					211	ACUCACUGUUCAUGAAUAC	GUAUUCAUGAACAGUGAGU	Cyn	[1662-1680]
212	GGCACUCUGAGUUCAUCAG	CUGAUGAACUCAGAGUGCC	Chmp	[158-176]
					213	GACCCUGAGGAUGAACACU	AGUGUUCAUCCUCAGGGUC		[458-476]
214	UAAACAUGUUUGUUAAAAC	GUUUUAACAAACAUGUUUA	大鼠	[1730-1748]
					215	UGGUUGGAAAACUGAGGCA	UGCCUCAGUUUUCCAACCA	Cyn	[998-1016]
216	CUUCCGAGUCAUCAAGAAG	CUUCUUGAUGACUCGGAAG	Chmp	[841-859]
					217	UGUAUCUUACUGGUCUGAA	UUCAGACCAGUAAGAUACA	Cyn	[1334-1352]
218	UCCUGUGGUUGGAAAACUG	CAGUUUUCCAACCACAGGA	Cyn	[993-1011]
					219	AGGGAUCACUUGGGAUCUU	AAGAUCCCAAGUGAUCCCU	Cyn	[1476-1494]
220	GCAUGAAUGUAAGAGUAGG	CCUACUCUUACAUUCAUGC	Cyn，Ms	[1443-1461]
					221	GUUACUGACAGUUAACAGU	ACUGUUAACUGUCAGUAAC	Cyn	[1190-1208]
222	AACAGCUGCUCAUUGAGGA	UCCUCAAUGAGCAGCUGUU	Cyn，Chmp	[876-894]
					223	AGAUAAGAUACUCACUGUU	AACAGUGAGUAUCUUAUCU	Cyn	[1653-1671]
224	CUGAGUUCAUCAGCAAACG	CGUUUGCUGAUGAACUCAG	Chmp	[164-182]

225	AGUGGUGUGACAUCCAGAG	CUCUGGAUGUCACACCACU		[1206-1224]
					226	ACAGUGGUGUGACAUCCAG	CUGGAUGUCACACCACUGU		[1204-1222]
227	AGGCAGCUAUCUUACAGAC	GUCUGUAAGAUAGCUGCCU	Cyn，大鼠，Ms	[1424-1442]
					228	UGUACCUUAUUAUUUUUGU	ACAAAAAUAAUAAGGUACA	Cyn	[1173-1191]
229	GACACUUGAAAAAUUACAC	GUGUAAUUUUUCAAGUGUC		[1496-1514]
					230	AAGAUAAGAUACUCACUGU	ACAGUGAGUAUCUUAUCUU	Cyn	[1652-1670]
231	AGGAGUGUUGAACUUCAAC	GUUGAAGUUCAACACUCCU	Cyn	[891-909]
					232	UGUACAGCUCGGAACAGCU	AGCUGUUCCGAGCUGUACA	Cyn，Chmp	[864-882]
233	GUCUGAAGGGACCAAGUGU	ACACUUGGUCCCUUCAGAC	Cyn	[1346-1364]
					234	CAGUACUGUAGCAUGAAAC	GUUUCAUGCUACAGUACUG	Cyn，大鼠，Ms，Rb	[1107-1125]
235	CAGGAAGCUCAUUGAGUUG	CAACUCAAUGAGCUUCCUG		[1052-1070]
					236	AGGGACUGAUUCCUGUGGU	ACCACAGGAAUCAGUCCCU	Cyn	[983-1001]
237	GCAAAGAACUACUGCGCCU	AGGCGCAGUAGUUCUUUGC	Chmp	[585-603]
					238	CUCGGAACAGCUGCUCAUU	AAUGAGCAGCUGUUCCGAG	Cyn，Chmp	[871-889]
239	CCAUCGUGUACUGCAGAGU	ACUCUGCAGUACACGAUGG		[1540-1558]
					240	AAGACAGAGACGACUGAAC	GUUCAGUCGUCUCUGUCUU		[934-952]
241	CAGGGAUCACUUGGGAUCU	AGAUCCCAAGUGAUCCCUG	Cyn	[1475-1493]
					242	GUAGGCAGCUAUCUUACAG	CUGUAAGAUAGCUGCCUAC	Cyn	[1422-1440]
243	UAGCAUGAAACAAAGGCUU	AAGCCUUUGUUUCAUGCUA	Cyn，大鼠，Ms	[1115-1133]
					244	ACUGUUCAUGAAUACACUU	AAGUGUAUUCAUGAACAGU	Cyn	[1666-1684]
245	GUCAGGGAUCACUUGGGAU	AUCCCAAGUGAUCCCUGAC	Cyn	[1473-1491]
					246	UUAAGACCUAUGCAAUAUU	AAUAUUGCAUAGGUCUUAA	Ms	[1697-1715]
247	CCUAUGCAAUAUUUUUUAC	GUAAAAAAUAUUGCAUAGG		[1703-1721]
					248	UUUUGUAUCUUGUUUUUCU	AGAAAAACAAGAUACAAAA		[1377-1395]
249	GCUGCUCAUUGAGGAGUGU	ACACUCCUCAAUGAGCAGC	Cyn，Rb，Chmp	[880-898]
					250	UAGAACUGUUUACAUGAAG	CUUCAUGUAAACAGUUCUA	Cyn，大鼠	[1636-1654]
251	ACUGACAGUUAACAGUGGU	ACCACUGUUAACUGUCAGU	Cyn	[1193-1211]

252	GAGACGACUGAACUUUUGG	CCAAAAGUUCAGUCGUCUC		[940-958]
					253	AGCUAUCUUACAGACGCAU	AUGCGUCUGUAAGAUAGCU	Cyn	[1428-1446]
254	GUUGUUUGUUUUGUAUCUU	AAGAUACAAAACAAACAAC		[1369-1387]
					255	CAUCAAGAAGAAGCUGUAC	GUACAGCUUCUUCUUGAUG	Cyn，Rb，Chmp	[850-868]
256	ACACUUGAUGUUCAAGUAU	AUACUUGAACAUCAAGUGU	Ms	[1679-1697]
					257	UAUUUUUGUUACUGACAGU	ACUGUCAGUAACAAAAAUA	Cyn	[1183-1201]
258	CCCUCAGUACUGUAGCAUG	CAUGCUACAGUACUGAGGG	Cyn，大鼠，Ms	[1103-1121]
					259	AGCAUGUACCUUAUUAUUU	AAAUAAUAAGGUACAUGCU	Cyn	[1169-1187]
260	AUCUUACAGACGCAUGAAU	AUUCAUGCGUCUGUAAGAU	Cyn	[1432-1450]
					261	UGUUUGUUUUGUAUCUUGU	ACAAGAUACAAAACAAACA		[1371-1389]
262	GUUUACAUGAAGAUAAGAU	AUCUUAUCUUCAUGUAAAC	Cyn	[1643-1661]
					263	UCUUAGCAGUUCUCGCUGA	UCAGCGAGAACUGCUAAGA		[112-130]
264	GCAAUAUUUUUUACUUUUC	GAAAAGUAAAAAAUAUUGC		[1708-1726]
					265	UGGGCAAAGAACUACUGCG	CGCAGUAGUUCUUUGCCCA	Chmp	[582-600]
266	CUGAUCGGAGCAUCACUAC	GUAGUGAUGCUCCGAUCAG	Cyn	[1394-1412]
					267	CAUCACUACUGACCUGUUG	CAACAGGUCAGUAGUGAUG	Cyn	[1404-1422]
268	UGUAUCUUGUUUUUCUGAU	AUCAGAAAAACAAGAUACA		[1380-1398]
					269	CUGUUGUAGGCAGCUAUCU	AGAUAGCUGCCUACAACAG	Cyn	[1417-1435]
270	CUAUGCAAUAUUUUUUACU	AGUAAAAAAUAUUGCAUAG		[1704-1722]
					271	UUCUAAUAAACAUGUUUGU	ACAAACAUGUUUAUUAGAA	大鼠，Ms	[1724-1742]
272	UUACAGACGCAUGAAUGUA	UACAUUCAUGCGUCUGUAA	Cyn	[1435-1453]
					273	CAGGACGCACUUGUCUUAG	CUAAGACAAGUGCGUCCUG		[99-117]
274	GUGUAUCUUACUGGUCUGA	UCAGACCAGUAAGAUACAC	Cyn	[1333-1351]
					275	UCACUUGGGAUCUUUGACA	UGUCAAAGAUCCCAAGUGA	Cyn	[1481-1499]
276	UUGUAUCUUGUUUUUCUGA	UCAGAAAAACAAGAUACAA		[1379-1397]
					277	CUUGAAAAAUUACACCUGG	CCAGGUGUAAUUUUUCAAG		[1500-1518]
278	CAAGUAUUAAGACCUAUGC	GCAUAGGUCUUAAUACUUG	Ms	[1691-1709]

279	AGAAGCUGUACAGCUCGGA	UCCGAGCUGUACAGCUUCU	Cyn，Rb，Chmp	[858-876]
					280	UGUUACUGACAGUUAACAG	CUGUUAACUGUCAGUAACA	Cyn	[1189-1207]
281	CUGAGGAUGAACACUUGUG	CACAAGUGUUCAUCCUCAG		[462-480]
					282	AUUGAGGAGUGUUGAACUU	AAGUUCAACACUCCUCAAU	Cyn	[887-905]
283	CUCCAAGACAGAGACGACU	AGUCGUCUCUGUCUUGGAG		[930-948]
					284	UGUGGUUGGAAAACUGAGG	CCUCAGUUUUCCAACCACA	Cyn	[996-1014]
285	GCAGCUAUCUUACAGACGC	GCGUCUGUAAGAUAGCUGC	Cyn	[1426-1444]
					286	GAUCGGAGCAUCACUACUG	CAGUAGUGAUGCUCCGAUC	Cyn	[1396-1414]
287	GUUAACAGUGGUGUGACAU	AUGUCACACCACUGUUAAC		[1200-1218]
					288	CUUGUUUUUCUGAUCGGAG	CUCCGAUCAGAAAAACAAG		[1385-1403]
289	AGAAGAAGCUGUACAGCUC	GAGCUGUACAGCUUCUUCU	Cyn，Rb，Chmp	[855-873]
					290	UGUACUGCAGAGUUGAGCU	AGCUCAACUCUGCAGUACA		[1546-1564]
291	CACUUGAAAAAUUACACCU	AGGUGUAAUUUUUCAAGUG		[1498-1516]
					292	GAAGAUAAGAUACUCACUG	CAGUGAGUAUCUUAUCUUC	Cyn	[1651-1669]
293	AUCUAGAACUGUUUACAUG	CAUGUAAACAGUUCUAGAU	Cyn，大鼠	[1633-1651]
					294	GGGAAUAGUGUUUCCCAGG	CCUGGGAAACACUAUUCCC		[1037-1055]
295	GUUCAUCAGCAAACGCCCU	AGGGCGUUUGCUGAUGAAC	Cyn，Chmp	[168-186]
					296	ACAAGGCUUCCAGCUGGAU	AUCCAGCUGGAAGCCUUGU		[1142-1160]
297	GAAUGUAAGAGUAGGAAGG	CCUUCCUACUCUUACAUUC	Cyn	[1447-1465]
					298	CAGCUGCGUUUAAGCCUUC	GAAGGCUUAAACGCAGCUG		[1519-1537]
299	GUGUUUGUUGUUUGUUUUG	CAAAACAAACAACAAACAC		[1363-1381]
					300	UUUUUGUUACUGACAGUUA	UAACUGUCAGUAACAAAAA	Cyn	[1185-1203]
301	AGGACGCACUUGUCUUAGC	GCUAAGACAAGUGCGUCCU		[100-118]
					302	ACCCUGAGGAUGAACACUU	AAGUGUUCAUCCUCAGGGU		[459-477]
303	AGACGACUGAACUUUUGGG	CCCAAAAGUUCAGUCGUCU		[941-959]
					304	UCUUACUGGUCUGAAGGGA	UCCCUUCAGACCAGUAAGA	Cyn	[1338-1356]
305	UUGUUACUGACAGUUAACA	UGUUAACUGUCAGUAACAA	Cyn	[1188-1206]

306	CUGUAGCAUGAAACAAAGG	CCUUUGUUUCAUGCUACAG	Cyn，大鼠，Ms，Rb	[1112-1130]
					307	ACAGAGACGACUGAACUUU	AAAGUUCAGUCGUCUCUGU		[937-955]
308	UGUUCAAGUAUUAAGACCU	AGGUCUUAAUACUUGAACA	Ms	[1687-1705]
					309	CAGGUGGGCAAAGAACUAC	GUAGUUCUUUGCCCACCUG	Cyn，Chmp	[578-596]
310	AGCUGAGGGACUGAUUCCU	AGGAAUCAGUCCCUCAGCU	Cyn	[978-996]
					311	AUACUCACUGUUCAUGAAU	AUUCAUGAACAGUGAGUAU	Cyn	[1660-1678]
312	AUUAAGACCUAUGCAAUAU	AUAUUGCAUAGGUCUUAAU	Ms	[1696-1714]
					313	CUUAGCAGUUCUCGCUGAC	GUCAGCGAGAACUGCUAAG		[113-131]
314	CACUUGGGAUCUUUGACAC	GUGUCAAAGAUCCCAAGUG	Cyn	[1482-1500]
					315	AAGAAGAAGCUGUACAGCU	AGCUGUACAGCUUCUUCUU	Cyn，Rb，Chmp	[854-872]
316	UAUUAUUUUUGUUACUGAC	GUCAGUAACAAAAAUAAUA	Cyn	[1180-1198]
					317	ACCUUAUUAUUUUUGUUAC	GUAACAAAAAUAAUAAGGU	Cyn	[1176-1194]
318	AAUAGUGUUUCCCAGGAAG	CUUCCUGGGAAACACUAUU		[1040-1058]
					319	UACUGGUCUGAAGGGACCA	UGGUCCCUUCAGACCAGUA	Cyn	[1341-1359]
320	ACAUGAAGAUAAGAUACUC	GAGUAUCUUAUCUUCAUGU	Cyn	[1647-1665]
					321	AUCAAGAAGAAGCUGUACA	UGUACAGCUUCUUCUUGAU	Cyn，Rb，Chmp	[851-869]
322	GUAUCUUGUUUUUCUGAUC	GAUCAGAAAAACAAGAUAC		[1381-1399]
					323	UCGGAGCAUCACUACUGAC	GUCAGUAGUGAUGCUCCGA	Cyn	[1398-1416]
324	UGUUUGUUGUUUGUUUUGU	ACAAAACAAACAACAAACA		[1364-1382]
					325	GUUUUUCUGAUCGGAGCAU	AUGCUCCGAUCAGAAAAAC		[1388-1406]
326	UGGUGUGACAUCCAGAGAG	CUCUCUGGAUGUCACACCA		[1208-1226]
					327	CAUGAAACAAAGGCUUAGG	CCUAAGCCUUUGUUUCAUG	Cyn，Ms	[1118-1136]
328	CGAGUCAUCAAGAAGAAGC	GCUUCUUCUUGAUGACUCG	Cyn，Chmp	[845-863]
					329	UAGUGUUUCCCAGGAAGCU	AGCUUCCUGGGAAACACUA		[1042-1060]
330	AGUUCAUCAGCAAACGCCC	GGGCGUUUGCUGAUGAACU	Cyn，Chmp	[167-185]
					331	UCUGUCCUCACCAUGCCUA	UAGGCAUGGUGAGGACAGA	Cyn，Chmp	[191-209]
332	CUCACCAUGCCUAGCCUUU	AAAGGCUAGGCAUGGUGAG	Cyn，Rb，Chmp	[197-215]

333	CUGACAGUUAACAGUGGUG	CACCACUGUUAACUGUCAG	Cyn	[1194-1212]
					334	AUCUGGGUCUUCCAUCUAG	CUAGAUGGAAGACCCAGAU		[1620-1638]
335	UUCAAGUAUUAAGACCUAU	AUAGGUCUUAAUACUUGAA	Ms	[1689-1707]
					336	UGGGUCUUCCAUCUAGAAC	GUUCUAGAUGGAAGACCCA	大鼠，Ms	[1623-1641]
337	UCCCAGGAAGCUCAUUGAG	CUCAAUGAGCUUCCUGGGA		[1049-1067]
					338	GGUUGGAAAACUGAGGCAG	CUGCCUCAGUUUUCCAACC	Cyn	[999-1017]
339	UGAAUGUAAGAGUAGGAAG	CUUCCUACUCUUACAUUCA	Cyn	[1446-1464]
					340	GGCAGCUAUCUUACAGACG	CGUCUGUAAGAUAGCUGCC	Cyn	[1425-1443]
341	UUUGUUACUGACAGUUAAC	GUUAACUGUCAGUAACAAA	Cyn	[1187-1205]
					342	GUUGAACUUCAACCUGAGG	CCUCAGGUUGAAGUUCAAC		[897-915]
343	GUUGGAAAACUGAGGCAGC	GCUGCCUCAGUUUUCCAAC	Cyn	[1000-1018]
					344	UGUCUUAGCAGUUCUCGCU	AGCGAGAACUGCUAAGACA		[110-128]
345	CUUACUGGUCUGAAGGGAC	GUCCCUUCAGACCAGUAAG	Cyn	[1339-1357]
					346	UGACCUGUUGUAGGCAGCU	AGCUGCCUACAACAGGUCA	Cyn	[1413-1431]
347	GCUAUCUUACAGACGCAUG	CAUGCGUCUGUAAGAUAGC	Cyn	[1429-1447]
					348	UUUGUAUCUUGUUUUUCUG	CAGAAAAACAAGAUACAAA		[1378-1396]
349	UACUGACAGUUAACAGUGG	CCACUGUUAACUGUCAGUA	Cyn	[1192-1210]
					350	UUGACACUUGAAAAAUUAC	GUAAUUUUUCAAGUGUCAA		[1494-1512]
351	CACUACUGACCUGUUGUAG	CUACAACAGGUCAGUAGUG	Cyn	[1407-1425]
					352	UGACAUCCAGAGAGCAGCU	AGCUGCUCUCUGGAUGUCA		[1213-1231]
353	ACUUUUCUAAUAAACAUGU	ACAUGUUUAUUAGAAAAGU	大鼠，Ms	[1720-1738]
					354	AUUAUUUUUGUUACUGACA	UGUCAGUAACAAAAAUAAU	Cyn	[1181-1199]
355	GAAGAAGCUGUACAGCUCG	CGAGCUGUACAGCUUCUUC	Cyn，Rb，Chmp	[856-874]
					356	GUGGGCAAAGAACUACUGC	GCAGUAGUUCUUUGCCCAC	Chmp	[581-599]
357	GCACUUGUCUUAGCAGUUC	GAACUGCUAAGACAAGUGC		[105-123]
					358	AUCGUGUACUGCAGAGUUG	CAACUCUGCAGUACACGAU		[1542-1560]
359	UGCUCAUUGAGGAGUGUUG	CAACACUCCUCAAUGAGCA	Cyn，Rb，Chmp	[882-900]

360	GGAGUGUUGAACUUCAACC	GGUUGAAGUUCAACACUCC	Cyn	[892-910]
					361	CUUGGGAUCUUUGACACUU	AAGUGUCAAAGAUCCCAAG	Cyn	[1484-1502]
362	UGAGGGACUGAUUCCUGUG	CACAGGAAUCAGUCCCUCA	Cyn	[981-999]
					363	UCAAGUAUUAAGACCUAUG	CAUAGGUCUUAAUACUUGA	Ms	[1690-1708]
364	UUGAUGUUCAAGUAUUAAG	CUUAAUACUUGAACAUCAA	Ms	[1683-1701]
					365	UCACUGUUCAUGAAUACAC	GUGUAUUCAUGAACAGUGA	Cyn	[1664-1682]
366	GUUUCCCAGGAAGCUCAUU	AAUGAGCUUCCUGGGAAAC		[1046-1064]
					367	UCUUUGACACUUGAAAAAU	AUUUUUCAAGUGUCAAAGA		[1491-1509]
368	CUACUGACCUGUUGUAGGC	GCCUACAACAGGUCAGUAG	Cyn	[1409-1427]
					369	CAAGAAGAAGCUGUACAGC	GCUGUACAGCUUCUUCUUG	Cyn，Rb，Chmp	[853-871]
370	AGUGUUGAACUUCAACCUG	CAGGUUGAAGUUCAACACU	Cyn	[894-912]
					371	AUGAAGAUAAGAUACUCAC	GUGAGUAUCUUAUCUUCAU	Cyn	[1649-1667]
372	UUGGGAUCUUUGACACUUG	CAAGUGUCAAAGAUCCCAA	Cyn	[1485-1503]
					373	ACUUGGGAUCUUUGACACU	AGUGUCAAAGAUCCCAAGU	Cyn	[1483-1501]
374	UGACAGUUAACAGUGGUGU	ACACCACUGUUAACUGUCA	Cyn	[1195-1213]
					375	UCUAAUAAACAUGUUUGUU	AACAAACAUGUUUAUUAGA	大鼠，Ms	[1725-1743]
376	AACAUGUUUGUUAAAACAG	CUGUUUUAACAAACAUGUU		[1732-1750]
					377	ACAGCUGCUCAUUGAGGAG	CUCCUCAAUGAGCAGCUGU	Cyn，Chmp	[877-895]
378	ACUUGUCUUAGCAGUUCUC	GAGAACUGCUAAGACAAGU		[107-125]
					379	AUCACUACUGACCUGUUGU	ACAACAGGUCAGUAGUGAU	Cyn	[1405-1423]
380	UCACCAUGCCUAGCCUUUG	CAAAGGCUAGGCAUGGUGA	Cyn，Rb，Chmp	[198-216]
					381	ACUUGAAAAAUUACACCUG	CAGGUGUAAUUUUUCAAGU		[1499-1517]
382	UUGUUUUUCUGAUCGGAGC	GCUCCGAUCAGAAAAACAA		[1386-1404]
					383	GCACUCUGAGUUCAUCAGC	GCUGAUGAACUCAGAGUGC	Chmp	[159-177]
384	GUCUUCCAUCUAGAACUGU	ACAGUUCUAGAUGGAAGAC	Cyn，大鼠	[1626-1644]
					385	UUCGCACACCCAUUCAAGC	GCUUGAAUGGGUGUGCGAA		[78-96]
386	UUGUUUGUUUUGUAUCUUG	CAAGAUACAAAACAAACAA		[1370-1388]

387	UUUGUUUUGUAUCUUGUUU	AAACAAGAUACAAAACAAA		[1373-1391]
					388	UACUGACCUGUUGUAGGCA	UGCCUACAACAGGUCAGUA	Cyn	[1410-1428]
389	UACAUGAAGAUAAGAUACU	AGUAUCUUAUCUUCAUGUA	Cyn	[1646-1664]
					390	UUAUUUUUGUUACUGACAG	CUGUCAGUAACAAAAAUAA	Cyn	[1182-1200]
391	ACUGACCUGUUGUAGGCAG	CUGCCUACAACAGGUCAGU	Cyn	[1411-1429]
					392	UUGUAGGCAGCUAUCUUAC	GUAAGAUAGCUGCCUACAA	Cyn	[1420-1438]
393	UCUUACAGACGCAUGAAUG	CAUUCAUGCGUCUGUAAGA	Cyn	[1433-1451]
					394	UUGUUUUGUAUCUUGUUUU	AAAACAAGAUACAAAACAA		[1374-1392]
395	UCUGAGUUCAUCAGCAAAC	GUUUGCUGAUGAACUCAGA	Chmp	[163-181]
					396	UUACAUGAAGAUAAGAUAC	GUAUCUUAUCUUCAUGUAA	Cyn	[1645-1663]
397	AGACGCAUGAAUGUAAGAG	CUCUUACAUUCAUGCGUCU	Cyn	[1439-1457]
					398	UUCCUGUGGUUGGAAAACU	AGUUUUCCAACCACAGGAA	Cyn	[992-1010]
399	AGUCAUCAAGAAGAAGCUG	CAGCUUCUUCUUGAUGACU	Cyn，Chmp	[847-865]
					400	CUGCUCAUUGAGGAGUGUU	AACACUCCUCAAUGAGCAG	Cyn，Rb，Chmp	[881-899]
401	GUCAUCAAGAAGAAGCUGU	ACAGCUUCUUCUUGAUGAC	Cyn，Rb，Chmp	[848-866]
					402	AAGCUGUACAGCUCGGAAC	GUUCCGAGCUGUACAGCUU	Cyn，Chmp	[860-878]
403	UUAACAGUGGUGUGACAUC	GAUGUCACACCACUGUUAA		[1201-1219]
					404	ACUACUGACCUGUUGUAGG	CCUACAACAGGUCAGUAGU	Cyn	[1408-1426]
405	AGCUGCUCAUUGAGGAGUG	CACUCCUCAAUGAGCAGCU	Cyn，Rb，Chmp	[879-897]
					406	GGACUGAUUCCUGUGGUUG	CAACCACAGGAAUCAGUCC	Cyn	[985-1003]
407	UUUCUGAUCGGAGCAUCAC	GUGAUGCUCCGAUCAGAAA	Cyn	[1391-1409]
					408	GUACUGCAGAGUUGAGCUG	CAGCUCAACUCUGCAGUAC		[1547-1565]
409	UGAGUUCAUCAGCAAACGC	GCGUUUGCUGAUGAACUCA	Cyn，Chmp	[165-183]
					410	GAGUUCAUCAGCAAACGCC	GGCGUUUGCUGAUGAACUC	Cyn，Chmp	[166-184]
411	UCGGAACAGCUGCUCAUUG	CAAUGAGCAGCUGUUCCGA	Cyn，Chmp	[872-890]
					412	AGUGACCCUGAGGAUGAAC	GUUCAUCCUCAGGGUCACU	Cyn，Chmp	[455-473]
413	GUGGUUGGAAAACUGAGGC	GCCUCAGUUUUCCAACCAC	Cyn	[997-1015]

414	GAUAAGAUACUCACUGUUC	GAACAGUGAGUAUCUUAUC	Cyn	[1654-1672]
					415	GAACAGCUGCUCAUUGAGG	CCUCAAUGAGCAGCUGUUC	Cyn，Chmp	[875-893]
416	UCUGAAGGGACCAAGUGUG	CACACUUGGUCCCUUCAGA	Cyn	[1347-1365]
					417	UACUUUUCUAAUAAACAUG	CAUGUUUAUUAGAAAAGUA	大鼠，Ms	[1719-1737]
418	ACACUUGAAAAAUUACACC	GGUGUAAUUUUUCAAGUGU		[1497-1515]
					419	UAUCUUACUGGUCUGAAGG	CCUUCAGACCAGUAAGAUA	Cyn	[1336-1354]
420	UCCAUCUAGAACUGUUUAC	GUAAACAGUUCUAGAUGGA	Cyn，大鼠	[1630-1648]
					421	CAAAGAACUACUGCGCCUG	CAGGCGCAGUAGUUCUUUG	Chmp	[586-604]
422	AUCACUUGGGAUCUUUGAC	GUCAAAGAUCCCAAGUGAU	Cyn	[1480-1498]
					423	GUCUUAGCAGUUCUCGCUG	CAGCGAGAACUGCUAAGAC		[111-129]
424	AAAGAACUACUGCGCCUGG	CCAGGCGCAGUAGUUCUUU	Chmp	[587-605]
					425	AUACACUUGAUGUUCAAGU	ACUUGAACAUCAAGUGUAU	Cyn，大鼠，Ms	[1677-1695]
426	AGGAAGCUCAUUGAGUUGU	ACAACUCAAUGAGCUUCCU		[1053-1071]
					427	GUGUACUGCAGAGUUGAGC	GCUCAACUCUGCAGUACAC		[1545-1563]
428	UGUGACAUCCAGAGAGCAG	CUGCUCUCUGGAUGUCACA		[1211-1229]
					429	UUGUCUUAGCAGUUCUCGC	GCGAGAACUGCUAAGACAA		[109-127]
430	UUGGAAAACUGAGGCAGCC	GGCUGCCUCAGUUUUCCAA	Cyn	[1001-1019]
					431	UAACAGUGGUGUGACAUCC	GGAUGUCACACCACUGUUA		[1202-1220]
432	UCCAAGACAGAGACGACUG	CAGUCGUCUCUGUCUUGGA		[931-949]
					433	AGUGUUUCCCAGGAAGCUC	GAGCUUCCUGGGAAACACU		[1043-1061]
434	AAGAAGCUGUACAGCUCGG	CCGAGCUGUACAGCUUCUU	Cyn，Rb，Chmp	[857-875]
					435	AUGAAACAAAGGCUUAGGG	CCCUAAGCCUUUGUUUCAU	Cyn	[1119-1137]
436	CUUAUUAUUUUUGUUACUG	CAGUAACAAAAAUAAUAAG	Cyn	[1178-1196]
					437	AUCUUGUUUUUCUGAUCGG	CCGAUCAGAAAAACAAGAU		[1383-1401]
438	AGCAUCACUACUGACCUGU	ACAGGUCAGUAGUGAUGCU	Cyn	[1402-1420]
					439	AUGUUCAAGUAUUAAGACC	GGUCUUAAUACUUGAACAU	Ms	[1686-1704]
440	UCAUUGAGGAGUGUUGAAC	GUUCAACACUCCUCAAUGA	Cyn	[885-903]

441	AGCUGCGUUUAAGCCUUCC	GGAAGGCUUAAACGCAGCU		[1520-1538]
					442	UUACUGACAGUUAACAGUG	CACUGUUAACUGUCAGUAA	Cyn	[1191-1209]
443	AUUCCUGUGGUUGGAAAAC	GUUUUCCAACCACAGGAAU	Cyn	[991-1009]
					444	AAUACACUUGAUGUUCAAG	CUUGAACAUCAAGUGUAUU	Cyn，大鼠，Ms	[1676-1694]
445	CUGUUCAUGAAUACACUUG	CAAGUGUAUUCAUGAACAG	Cyn	[1667-1685]
					446	UUGUUGUUUGUUUUGUAUC	GAUACAAAACAAACAACAA		[1367-1385]
447	UUUCUAAUAAACAUGUUUG	CAAACAUGUUUAUUAGAAA	大鼠，Ms	[1723-1741]
					448	AUCUUACUGGUCUGAAGGG	CCCUUCAGACCAGUAAGAU	Cyn	[1337-1355]
449	UUACUGGUCUGAAGGGACC	GGUCCCUUCAGACCAGUAA	Cyn	[1340-1358]
					450	AAGAUACUCACUGUUCAUG	CAUGAACAGUGAGUAUCUU	Cyn	[1657-1675]
451	AUUUUUGUUACUGACAGUU	AACUGUCAGUAACAAAAAU	Cyn	[1184-1202]
					452	CAGCUGCUCAUUGAGGAGU	ACUCCUCAAUGAGCAGCUG	Cyn，Rb，Chmp	[878-896]
453	GUUUUGUAUCUUGUUUUUC	GAAAAACAAGAUACAAAAC		[1376-1394]
					454	AUAGUGUUUCCCAGGAAGC	GCUUCCUGGGAAACACUAU		[1041-1059]
455	UGUAGCAUGAAACAAAGGC	GCCUUUGUUUCAUGCUACA	Cyn，大鼠，Ms，Rb	[1113-1131]
					456	UCAGGGAUCACUUGGGAUC	GAUCCCAAGUGAUCCCUGA	Cyn	[1474-1492]
457	AAUGUAAGAGUAGGAAGGG	CCCUUCCUACUCUUACAUU	Cyn	[1448-1466]
					458	UUCAUGAAUACACUUGAUG	CAUCAAGUGUAUUCAUGAA	Cyn，大鼠，Ms	[1670-1688]
459	UUUUUCUGAUCGGAGCAUC	GAUGCUCCGAUCAGAAAAA		[1389-1407]
					460	CUUGUCUUAGCAGUUCUCG	CGAGAACUGCUAAGACAAG		[108-126]
461	AUGUACCUUAUUAUUUUUG	CAAAAAUAAUAAGGUACAU	Cyn	[1172-1190]
					462	UAUCUUGUUUUUCUGAUCG	CGAUCAGAAAAACAAGAUA		[1382-1400]
463	UUUCCCAGGAAGCUCAUUG	CAAUGAGCUUCCUGGGAAA		[1047-1065]
					464	UACUGCAGAGUUGAGCUGG	CCAGCUCAACUCUGCAGUA		[1548-1566]
465	AUGAAUACACUUGAUGUUC	GAACAUCAAGUGUAUUCAU	Cyn，大鼠，Ms	[1673-1691]
					466	UUAGCAGUUCUCGCUGACC	GGUCAGCGAGAACUGCUAA		[114-132]
467	UUGAGGAGUGUUGAACUUC	GAAGUUCAACACUCCUCAA	CYN	[888-906]

468	UUCAUCAGCAAACGCCCUG	CAGGGCGUUUGCUGAUGAA	CYN，CHMP	[169-187]
					469	UUGAACUUCAACCUGAGGG	CCCUCAGGUUGAAGUUCAA		[898-916]
470	GUGCCAACCUGAUGCAGCU	AGCAGCAUCAGGUUGGCAC

表B 15DDIT4L-DNA-损伤诱导转录体4-类

表B 16FAS-Fas(TNF受体超家族，成员6)(FAS)

No.

正义链siRNA

反义链siRNA

其他Sp

人-23510419：347-1354

1	GGUCUAGAGUGAAAAACAA	UUGUUUUUCACUCUAGACC		[1348-1366]
					2	CUGUGAAGAUAGUUAUAAA	UUUAUAACUAUCUUCACAG		[2553-2571]
3	GCUAGAUUAUCGUCCAAAA	UUUUGGACGAUAAUCUAGC		[392-410]
					4	CCUGGAACCACCUAAAGAA	UUCUUUAGGUGGUUCCAGG		[2584-2602]
5	CAAACUUCAUCAAGAGUAA	UUACUCUUGAUGAAGUUUG		[1552-1570]
					6	GCUUAGAAGUGGAAAUAAA	UUUAUUUCCACUUCUAAGC		[681-699]
7	CCAGCAACACCAAGUGCAA	UUGCACUUGGUGUUGCUGG		[825-843]
					8	CCAAAAUAGAUGAGAUCAA	UUGAUCUCAUCUAUUUUGG		[1116-1134]
9	GACACUAAGUCAAGUUAAA	UUUAACUUGACUUAGUGUC		[1066-1084]
					10	GAUUAAAGAUCUCAAAAAA	UUUUUUGAGAUCUUUAAUC		[1228-1246]
11	CAAGAAUGACAAUGUCCAA	UUGGACAUUGUCAUUCUUG		[1132-1150]
					12	CAUGAAUCUCCAACCUUAA	UUAAGGUUGGAGAUUCAUG		[974-992]
13	GGUAAAAGUACGUAAUUAA	UUAAUUACGUACUUUUACC		[2656-2674]
					14	GAGGAAGGAUCCAGAUCUA	UAGAUCUGGAUCCUUCCUC		[845-863]
15	GCACAGAAAGGAAAACCAA	UUGGUUUUCCUUUCUGUGC		[949-967]
					16	CAAGGAUGUUUAAAAUCUA	UAGAUUUUAAACAUCCUUG		[1523-1541]
17	GAAAUAUCACCAAAAAAUA	UAUUUUUUGGUGAUAUUUC		[2159-2177]
					18	CAGAAAGCACAGAAAGGAA	UUCCUUUCUGUGCUUUCUG		[943-961]
19	CCUGGUUUGGAGAUACUAA	UUAGUAUCUCCAAACCAGG		[2222-2240]
					20	CUACUAUCCUACGUUUAAA	UUUAAACGUAGGAUAGUAG		[2468-2486]
21	GUAAAAGUACGUAAUUAAA	UUUAAUUACGUACUUUUAC		[2657-2675]
					22	CACCAAAUGUGAACAUGGA	UCCAUGUUCACAUUUGGUG		[784-802]
23	CAAUAAUGUCCCAUGUAAA	UUUACAUGGGACAUUAUUG		[2342-2360]
					24	CUGUGACCCUUGCACCAAA	UUUGGUGCAAGGGUCACAG		[772-790]
25	CAUGGAAAUAUCACCAAAA	UUUUGGUGAUAUUUCCAUG		[2155-2173]
					26	AGCAGAACAGAAAGUUCAA	UUGAACUUUCUGUUCUGCU		[1156-1174]
27	CCUCCAAGGAUGUUUAAAA	UUUUAAACAUCCUUGGAGG		[1519-1537]

28	CCUUGGUGCUCAUCUUAAU	AUUAAGAUGAGCACCAAGG		[2117-2135]
					29	GCAGGAGAGUAUUACUAGA	UCUAGUAAUACUCUCCUGC		[2075-2093]
30	ACUUAAUAGUCCACCAAAA	UUUUGGUGGACUAUUAAGU		[2177-2195]
					31	CUGAGAAGAUCAUAUUUAU	AUAAAUAUGAUCUUCUCAG		[1849-1867]
32	UGGAAAUAUCACCAAAAAA	UUUUUUGGUGAUAUUUCCA		[2157-2175]
					33	CAAAGAUGAUAAAAUAGAU	AUCUAUUUUAUCAUCUUUG		[2293-2311]
34	UCAACUUCAUGGAAAGAAA	UUUCUUUCCAUGAAGUUGA		[1192-1210]
					35	GGAAAACAAACUUCAUCAA	UUGAUGAAGUUUGUUUUCC		[1546-1564]
36	CCAUGUUUGCAAUCAAAGA	UCUUUGAUUGCAAACAUGG		[2280-2298]
					37	CAUGCUAAGUACCCAAAUA	UAUUUGGGUACUUAGCAUG		[1580-1598]
38	AAAGAAUGGUGUCAAUGAA	UUCAUUGACACCAUUCUUU		[1096-1114]
					39	AGUGACUCAGAAAAUUCAA	UUGAAUUUUCUGAGUCACU		[1304-1322]
40	CAAAAGUGUUAAUGCCCAA	UUGGGCAUUAACACUUUUG		[406-424]
					41	GAGAAAGGAAGUACAGAAA	UUUCUGUACUUCCUUUCUC		[919-937]
42	CACCAAGUGCAAAGAGGAA	UUCCUCUUUGCACUUGGUG		[832-850]
					43	AUGGAAAUAUCACCAAAAA	UUUUUGGUGAUAUUUCCAU		[2156-2174]
44	CAUUACUAGUGACUCAGAA	UUCUGAGUCACUAGUAAUG		[1297-1315]
					45	CAGUGUAUGUUAGUACAAA	UUUGUACUAACAUACACUG		[1674-1692]
46	CAUGCAGAAAGCACAGAAA	UUUCUGUGCUUUCUGCAUG		[939-957]
					47	CCAAGUUUCUAAGAUUUAA	UUAAAUCUUAGAAACUUGG		[2438-2456]
48	CUUCAGAAAUGAAAUCCAA	UUGGAUUUCAUUUCUGAAG		[1324-1342]
					49	ACGUUUAAAUAUCUUUGAA	UUCAAAGAUAUUUAAACGU		[2478-2496]
50	GAAAGCACAGAAAGGAAAA	UUUUCCUUUCUGUGCUUUC		[945-963]
					51	AUUUGAGUGCAGAAUUUAA	UUAAAUUCUGCACUCAAAU		[1881-1899]
52	GCAGAGGAUGAAAGAUUAA	UUAAUCUUUCAUCCUCUGC		[1608-1626]
					53	CCAGGUGAAAGGAAAGCUA	UAGCUUUCCUUUCACCUGG		[539-557]
54	CAAAGAGGAAGGAUCCAGA	UCUGGAUCCUUCCUCUUUG		[841-859]

55	GUUUAUUGGUGUCAUAUUA	UAAUAUGACACCAAUAAAC		[1930-1948]
					56	GAAAAUUCAAACUUCAGAA	UUCUGAAGUUUGAAUUUUC		[1313-1331]
57	GAGGAAGACUGUUACUACA	UGUAGUAACAGUCUUCCUC		[457-475]
					58	ACCCAUGUUUGCAAUCAAA	UUUGAUUGCAAACAUGGGU		[2278-2296]
59	CGUUUAAAUAUCUUUGAAA	UUUCAAAGAUAUUUAAACG		[2479-2497]
					60	GAGUGCAGAAUUUAAAUAA	UUAUUUAAAUUCUGCACUC		[1885-1903]
61	GGACAUUACUAGUGACUCA	UGAGUCACUAGUAAUGUCC		[1294-1312]
					62	GCAAGACUGCCCUUAGAAA	UUUCUAAGGGCAGUCUUGC		[2197-2215]
63	AGAGAAAGGAAGUACAGAA	UUCUGUACUUCCUUUCUCU		[918-936]
					64	AAACCAAGGUUCUCAUGAA	UUCAUGAGAACCUUGGUUU		[961-979]
65	CACCAAAAAAUACUUAAUA	UAUUAAGUAUUUUUUGGUG		[2166-2184]
					66	CAUUGAUUAAAGAUCUCAA	UUGAGAUCUUUAAUCAAUG		[1224-1242]
67	AGGCAAGACUGCCCUUAGA	UCUAAGGGCAGUCUUGCCU		[2195-2213]
					68	CCCACUCUAUGAAUCAAUA	UAUUGAUUCAUAGAGUGGG		[1712-1730]
69	ACAGUUUAUUGGUGUCAUA	UAUGACACCAAUAAACUGU		[1927-1945]
					70	AGUGCAGAUGUAAACCAAA	UUUGGUUUACAUCUGCACU		[723-741]
71	GAGGAUUGCUCAACAACCA	UGGUUGUUGAGCAAUCCUC		[329-347]
					72	GGCUUAGAAGUGGAAAUAA	UUAUUUCCACUUCUAAGCC		[680-698]
73	AACCAAACUUUUUUUGUAA	UUACAAAAAAAGUUUGGUU		[735-753]
					74	GGAAAUAUCACCAAAAAAU	AUUUUUUGGUGAUAUUUCC		[2158-2176]
75	CACUCACCAGCAACACCAA	UUGGUGUUGCUGGUGAGUG		[819-837]
					76	AGAAGAUCAUAUUUAUGUA	UACAUAAAUAUGAUCUUCU		[1852-1870]
77	GUAGCUUUGUGACAUGUCA	UGACAUGUCACAAAGCUAC		[2256-2274]
					78	GGUUCUCAUGAAUCUCCAA	UUGGAGAUUCAUGAGAACC		[968-986]
79	CCACUUUGCCUCUAAAUUA	UAAUUUAGAGGCAAAGUGG		[1779-1797]
					80	CUGUAAAUGUAAACUGUGA	UCACAGUUUACAUUUACAG		[2540-2558]
81	AGCCCAUUUUUCUUCCAAA	UUUGGAAGAAAAAUGGGCU		[628-646]

82	CAGCAACACCAAGUGCAAA	UUUGCACUUGGUGUUGCUG		[826-844]
					83	GGCAGCUUAUACAUAGCAA	UUGCUAUGUAUAAGCUGCC		[2374-2392]
84	AAACCAAACUUUUUUUGUA	UACAAAAAAAGUUUGGUUU		[734-752]
					85	AGGAAUUGCUCUUGUCAUA	UAUGACAAGAGCAAUUCCU		[2416-2434]
86	GAUGUUGACUUGAGUAAAU	AUUUACUCAAGUCAACAUC		[1022-1040]
					87	AACCCAUGUUUGCAAUCAA	UUGAUUGCAAACAUGGGUU		[2277-2295]
88	CGAAAAUGUUCAAUAAUGU	ACAUUAUUGAACAUUUUCG		[2332-2350]
					89	CCCAAGUGACUGACAUCAA	UUGAUGUCAGUCACUUGGG		[420-438]
90	CUUGGUCUAGAGUGAAAAA	UUUUUCACUCUAGACCAAG		[1345-1363]
					91	GGUGUCAUAUUAUACAAUA	UAUUGUAUAAUAUGACACC		[1937-1955]
92	UUGUUUGGGUGAAGAGAAA	UUUCUCUUCACCCAAACAA		[906-924]
					93	GUGACUCAGAAAAUUCAAA	UUUGAAUUUUCUGAGUCAC		[1305-1323]
94	CAGAGAAAAUUCAGACUAU	AUAGUCUGAAUUUUCUCUG		[1266-1284]
					95	ACAUGGAAAUAUCACCAAA	UUUGGUGAUAUUUCCAUGU		[2154-2172]
96	CUAGGGACUGCACAGUCAA	UUGACUGUGCAGUCCCUAG		[555-573]
					97	GAUACUAACUGCUCUCAGA	UCUGAGAGCAGUUAGUAUC		[2233-2251]
98	CUAACUGCUCUCAGAGAAA	UUUCUCUGAGAGCAGUUAG		[2237-2255]
					99	CUCCAAGGAUGUUUAAAAU	AUUUUAAACAUCCUUGGAG		[1520-1538]
100	CUUUGUGACAUGUCAUGAA	UUCAUGACAUGUCACAAAG		[2260-2278]
					101	CUUUGAAAGUUUGUAUUAA	UUAAUACAAACUUUCAAAG		[2490-2508]
102	AAGUGCAGAUGUAAACCAA	UUGGUUUACAUCUGCACUU		[722-740]
					103	GAAGAUAGUUAUAAACUGA	UCAGUUUAUAACUAUCUUC		[2557-2575]
104	GGGUGAAGAGAAAGGAAGU	ACUUCCUUUCUCUUCACCC		[912-930]
					105	AAAUAGAUGAGAUCAAGAA	UUCUUGAUCUCAUCUAUUU		[1119-1137]
106	UCAGAAAAUUCAAACUUCA	UGAAGUUUGAAUUUUCUGA		[1310-1328]
					107	CCCGAAAAUGUUCAAUAAU	AUUAUUGAACAUUUUCGGG		[2330-2348]
108	CUAGAGUGAAAAACAACAA	UUGUUGUUUUUCACUCUAG		[1351-1369]

109	UGACUGACAUCAACUCCAA	UUGGAGUUGAUGUCAGUCA		[426-444]
					110	GGUACAUUUUAUCAUUUAU	AUAAAUGAUAAAAUGUACC		[1449-1467]
111	GUACAGAAAACAUGCAGAA	UUCUGCAUGUUUUCUGUAC		[929-947]
					112	GGGUACAUUUUAUCAUUUA	UAAAUGAUAAAAUGUACCC		[1448-1466]
113	CCCUUGCACCAAAUGUGAA	UUCACAUUUGGUGCAAGGG		[778-796]
					114	CAGUUCUGAGUAUAUGCAA	UUGCAUAUACUCAGAACUG		[1373-1391]
115	GGAAAACCAAGGUUCUCAU	AUGAGAACCUUGGUUUUCC		[958-976]
					116	GUGAACAUGGAAUCAUCAA	UUGAUGAUUCCAUGUUCAC		[792-810]
117	GAAAUAAACUGCACCCGGA	UCCGGGUGCAGUUUAUUUC		[692-710]
					118	GGGAAAACAAACUUCAUCA	UGAUGAAGUUUGUUUUCCC		[1545-1563]
119	UGCAAUUAGUGUUUGAAAA	UUUUCAAACACUAAUUGCA		[1387-1405]
					120	AGACCUUUGCACAGUUUAU	AUAAACUGUGCAAAGGUCU		[1917-1935]
121	GCUAAGUACCCAAAUAGGA	UCCUAUUUGGGUACUUAGC		[1583-1601]
					122	ACUACUAUCCUACGUUUAA	UUAAACGUAGGAUAGUAGU		[2467-2485]
123	ACCUUUUGCUGAAAUAUCA	UGAUAUUUCAGCAAAAGGU		[1743-1761]
					124	UGCAAUCAAAGAUGAUAAA	UUUAUCAUCUUUGAUUGCA		[2287-2305]
125	AGUGUAUGUUAGUACAAAU	AUUUGUACUAACAUACACU		[1675-1693]
					126	AAUGCACACUCACCAGCAA	UUGCUGGUGAGUGUGCAUU		[813-831]
127	CCCAAACAUGGAAAUAUCA	UGAUAUUUCCAUGUUUGGG		[2149-2167]
					128	CUAAAUUACCUCUGAUAAU	AUUAUCAGAGGUAAUUUAG		[1790-1808]
129	GUGUCAUAUUAUACAAUAU	AUAUUGUAUAAUAUGACAC		[1938-1956]
					130	UUUGAGUGCAGAAUUUAAA	UUUAAAUUCUGCACUCAAA		[1882-1900]
131	CCAAGUUGCUGAAUCAAUG	CAUUGAUUCAGCAACUUGG		[17-35]
					132	AAAACAAACUUCAUCAAGA	UCUUGAUGAAGUUUGUUUU		[1548-1566]
133	CAGCAGAACAGAAAGUUCA	UGAACUUUCUGUUCUGCUG		[1155-1173]
					134	GGCAAGACUGCCCUUAGAA	UUCUAAGGGCAGUCUUGCC		[2196-2214]
135	CUAUGAAUCAAUAGAAGAA	UUCUUCUAUUGAUUCAUAG		[1718-1736]

136	AAUCUAGUUGGGAAAACAA	UUGUUUUCCCAACUAGAUU		[1536-1554]
					137	UGAUGUUGACUUGAGUAAA	UUUACUCAAGUCAACAUCA		[1021-1039]
138	GAGUGAAAAACAACAAAUU	AAUUUGUUGUUUUUCACUC		[1354-1372]
					139	UGCAGAGGAUGAAAGAUUA	UAAUCUUUCAUCCUCUGCA		[1607-1625]
140	UGUGAAUUCACAUAGAAAA	UUUUCUAUGUGAAUUCACA		[1963-1981]
					141	GUUUGAAAAGAUUCUUAAU	AUUAAGAAUCUUUUCAAAC		[1397-1415]
142	CUACAGUUGAGACUCAGAA	UUCUGAGUCUCAACUGUAG		[471-489]
					143	AAAUAAGGCUCUACCUCAA	UUGAGGUAGAGCCUUAUUU		[1898-1916]
144	GCCUCUAAAUUACCUCUGA	UCAGAGGUAAUUUAGAGGC		[1786-1804]
					145	AGAAAGGAAGUACAGAAAA	UUUUCUGUACUUCCUUUCU		[920-938]
146	AUACCUGGAACCACCUAAA	UUUAGGUGGUUCCAGGUAU		[2581-2599]
					147	AGGCUUUGUUCGAAAGAAU	AUUCUUUCGAACAAAGCCU		[1084-1102]
148	CCAUGUAAAACCUGCUACA	UGUAGCAGGUUUUACAUGG		[2352-2370]
					149	UGCCUCCAAGGAUGUUUAA	UUAAACAUCCUUGGAGGCA		[1517-1535]
150	UAGAGUGAAAAACAACAAA	UUUGUUGUUUUUCACUCUA		[1352-1370]
					151	UCACAUAGAAAACAUUAAA	UUUAAUGUUUUCUAUGUGA		[1970-1988]
152	UCCUCCAGGUGAAAGGAAA	UUUCCUUUCACCUGGAGGA		[535-553]
					153	UGAUUAAAGAUCUCAAAAA	UUUUUGAGAUCUUUAAUCA		[1227-1245]
154	AGCUUGGUCUAGAGUGAAA	UUUCACUCUAGACCAAGCU		[1343-1361]
					155	UCGGAGGAUUGCUCAACAA	UUGUUGAGCAAUCCUCCGA		[326-344]
156	GAUGAAAGAUUAAGAUUAU	AUAAUCUUAAUCUUUCAUC		[1614-1632]
					157	GGAAGGCCUGCAUCAUGAU	AUCAUGAUGCAGGCCUUCC		[493-511]
158	GCUAUGACCUUUUGCUGAA	UUCAGCAAAAGGUCAUAGC		[1737-1755]
					159	GAAAGAAAGAAGCGUAUGA	UCAUACGCUUCUUUCUUUC		[1203-1221]
160	GCCUUGGUGCUCAUCUUAA	UUAAGAUGAGCACCAAGGC		[2116-2134]
					161	ACCAAAUGUGAACAUGGAA	UUCCAUGUUCACAUUUGGU		[785-803]
162	GAAGAUCAUAUUUAUGUAA	UUACAUAAAUAUGAUCUUC		[1853-1871]

163	CAUUUUUCUUCCAAAUGCA	UGCAUUUGGAAGAAAAAUG		[632-650]
					164	AAUAAUGUCCCAUGUAAAA	UUUUACAUGGGACAUUAUU		[2343-2361]
165	GCAUGCUAAGUACCCAAAU	AUUUGGGUACUUAGCAUGC		[1579-1597]
					166	UCAUGAAUCUCCAACCUUA	UAAGGUUGGAGAUUCAUGA		[973-991]
167	UGAAAUAUCAGUUACUGAA	UUCAGUAACUGAUAUUUCA		[1752-1770]
					168	GCCCAUUUUUCUUCCAAAU	AUUUGGAAGAAAAAUGGGC		[629-647]
169	AGAGGAUGAAAGAUUAAGA	UCUUAAUCUUUCAUCCUCU		[1610-1628]
					170	AGACUAUCAUCCUCAAGGA	UCCUUGAGGAUGAUAGUCU		[1278-1296]
171	GGAUUGGAAUUGAGGAAGA	UCUUCCUCAAUUCCAAUCC		[446-464]
					172	CAAACUUCAGAAAUGAAAU	AUUUCAUUUCUGAAGUUUG		[1320-1338]
173	GAAAGAAUGGUGUCAAUGA	UCAUUGACACCAUUCUUUC		[1095-1113]
					174	CCUCUAAAUUACCUCUGAU	AUCAGAGGUAAUUUAGAGG		[1787-1805]
175	UGUUUGAAAAGAUUCUUAA	UUAAGAAUCUUUUCAAACA		[1396-1414]
					176	UAGUGACUCAGAAAAUUCA	UGAAUUUUCUGAGUCACUA		[1303-1321]
177	AACUUUUUUUGUAACUCUA	UAGAGUUACAAAAAAAGUU		[740-758]
					178	CCUCAAAGACCUUUGCACA	UGUGCAAAGGUCUUUGAGG		[1911-1929]
179	UGGUCUAGAGUGAAAAACA	UGUUUUUCACUCUAGACCA		[1347-1365]
					180	CAUUUAUUAGCGCUGAAGA	UCUUCAGCGCUAAUAAAUG		[1461-1479]
181	CUCUGAUAAUUCUAGAGAU	AUCUCUAGAAUUAUCAGAG		[1799-1817]
					182	CCAGAAUACCAAGUGCAGA	UCUGCACUUGGUAUUCUGG		[712-730]
183	CUGCCUCCAAGGAUGUUUA	UAAACAUCCUUGGAGGCAG		[1516-1534]
					184	GCCUGGUUUGGAGAUACUA	UAGUAUCUCCAAACCAGGC		[2221-2239]
185	CAAUCAAAGAUGAUAAAAU	AUUUUAUCAUCUUUGAUUG		[2289-2307]
					186	CAAAAUAGAUGAGAUCAAG	CUUGAUCUCAUCUAUUUUG		[1117-1135]
187	AGUUUGUAUUAAAUGUGAA	UUCACAUUUAAUACAAACU		[2497-2515]
					188	CAAUCUUUGUACUCUUGCA	UGCAAGAGUACAAAGAUUG		[1249-1267]
189	GCUGGAGUCAUGACACUAA	UUAGUGUCAUGACUCCAGC		[1055-1073]

190	CUGAGUAUAUGCAAUUAGU	ACUAAUUGCAUAUACUCAG		[1378-1396]
					191	CCAUAUUUCUAAACUUUGU	ACAAAGUUUAGAAAUAUGG		[1822-1840]
192	GCUUGGUCUAGAGUGAAAA	UUUUCACUCUAGACCAAGC		[1344-1362]
					193	UAGAUGAGAUCAAGAAUGA	UCAUUCUUGAUCUCAUCUA		[1122-1140]
194	AGGGAUUGGAAUUGAGGAA	UUCCUCAAUUCCAAUCCCU		[444-462]
					195	AACUGUGAAGAUAGUUAUA	UAUAACUAUCUUCACAGUU		[2551-2569]
196	GGCAAUAAAUUUAUCUGAU	AUCAGAUAAAUUUAUUGCC		[1006-1024]
					197	GGCUCAAAACUACCUACUU	AAGUAGGUAGUUUUGAGCC		[2029-2047]
198	GAAUUUAAAUAAGGCUCUA	UAGAGCCUUAUUUAAAUUC		[1892-1910]
					199	AAUUGUGAAUUCACAUAGA	UCUAUGUGAAUUCACAAUU		[1960-1978]
200	GUUGCUAGAUUAUCGUCCA	UGGACGAUAAUCUAGCAAC		[389-407]
					201	AUGAGAUCAAGAAUGACAA	UUGUCAUUCUUGAUCUCAU		[1125-1143]
202	AAGAAAGAAGCGUAUGACA	UGUCAUACGCUUCUUUCUU		[1205-1223]
					203	UGAAGAGAAAGGAAGUACA	UGUACUUCCUUUCUCUUCA		[915-933]
204	GAGUGUAUGCAGAGGAUGA	UCAUCCUCUGCAUACACUC		[1600-1618]
					205	UUGGGUGAAGAGAAAGGAA	UUCCUUUCUCUUCACCCAA		[910-928]
206	CAUCAUCUGGAUUUAGGAA	UUCCUAAAUCCAGAUGAUG		[2402-2420]
					207	GAGUGAGGGAAGCGGUUUA	UAAACCGCUUCCCUCACUC		[165-183]
208	CUAUGACCUUUUGCUGAAA	UUUCAGCAAAAGGUCAUAG		[1738-1756]
					209	AGGAGUGUAUGCAGAGGAU	AUCCUCUGCAUACACUCCU		[1598-1616]
210	AGAAAGCACAGAAAGGAAA	UUUCCUUUCUGUGCUUUCU		[944-962]
					211	GUACGUAAUUAAAUAAUGU	ACAUUAUUUAAUUACGUAC		[2663-2681]
212	UGUAAAUGUAAACUGUGAA	UUCACAGUUUACAUUUACA		[2541-2559]
					213	GAAGGAUCCAGAUCUAACU	AGUUAGAUCUGGAUCCUUC		[848-866]
214	GUUGGGAAAACAAACUUCA	UGAAGUUUGUUUUCCCAAC		[1542-1560]
					215	AUCUAGUUGGGAAAACAAA	UUUGUUUUCCCAACUAGAU		[1537-1555]
216	GUAUUUGAGUGCAGAAUUU	AAAUUCUGCACUCAAAUAC		[1879-1897]

217	GAAGUGGAAAUAAACUGCA	UGCAGUUUAUUUCCACUUC		[686-704]
					218	GGCAUCAACUUCAUGGAAA	UUUCCAUGAAGUUGAUGCC		[1188-1206]
219	CAACAUAUUUGUAGAUUUU	AAAAUCUACAAAUAUGUUG		[1482-1500]
					220	CUGAAAUAUCAGUUACUGA	UCAGUAACUGAUAUUUCAG		[1751-1769]
221	UACCAAGUGCAGAUGUAAA	UUUACAUCUGCACUUGGUA		[718-736]
					222	CACUAAUUGUUUGGGUGAA	UUCACCCAAACAAUUAGUG		[900-918]
223	CCACCUAAAGAACUUCCAU	AUGGAAGUUCUUUAGGUGG		[2591-2609]
					224	AGGUAAAAGUACGUAAUUA	UAAUUACGUACUUUUACCU		[2655-2673]
225	GUUAUAAACUGAAGCAGAU	AUCUGCUUCAGUUUAUAAC		[2564-2582]
					226	GUACAAAUGUCUAUCCACA	UGUGGAUAGACAUUUGUAC		[1686-1704]
227	CCAAAAGUGUUAAUGCCCA	UGGGCAUUAACACUUUUGG		[405-423]
					228	GCAGAAAGCACAGAAAGGA	UCCUUUCUGUGCUUUCUGC		[942-960]
229	GCAGCUUAUACAUAGCAAU	AUUGCUAUGUAUAAGCUGC		[2375-2393]
					230	GAGGAUGAAAGAUUAAGAU	AUCUUAAUCUUUCAUCCUC		[1611-1629]
231	AAAAUAGAUGAGAUCAAGA	UCUUGAUCUCAUCUAUUUU		[1118-1136]
					232	UGUGAACAUGGAAUCAUCA	UGAUGAUUCCAUGUUCACA		[791-809]
233	GAGAAAAUUCAGACUAUCA	UGAUAGUCUGAAUUUUCUC		[1268-1286]
					234	AUGCAAUUAGUGUUUGAAA	UUUCAAACACUAAUUGCAU		[1386-1404]
235	AAGGCUUUGUUCGAAAGAA	UUCUUUCGAACAAAGCCUU		[1083-1101]
					236	UGUAAAACCUGCUACAAAU	AUUUGUAGCAGGUUUUACA		[2355-2373]
237	GCCUCCAAGGAUGUUUAAA	UUUAAACAUCCUUGGAGGC		[1518-1536]
					238	UUGUGAAUUCACAUAGAAA	UUUCUAUGUGAAUUCACAA		[1962-1980]
239	UCUGUAGUAUGAAUGUAAU	AUUACAUUCAUACUACAGA		[1655-1673]
					240	UCAUCAUCUGGAUUUAGGA	UCCUAAAUCCAGAUGAUGA		[2401-2419]
241	ACACCAAGUGCAAAGAGGA	UCCUCUUUGCACUUGGUGU		[831-849]
					242	UUGCUAGAUUAUCGUCCAA	UUGGACGAUAAUCUAGCAA		[390-408]
243	AAGGAAGUACAGAAAACAU	AUGUUUUCUGUACUUCCUU		[923-941]

244	AGCACAGAAAGGAAAACCA	UGGUUUUCCUUUCUGUGCU		[948-966]
					245	UUAUUGGUGUCAUAUUAUA	UAUAAUAUGACACCAAUAA		[1932-1950]
246	UUGGUGUCAUAUUAUACAA	UUGUAUAAUAUGACACCAA		[1935-1953]
					247	GGCAUGCUAAGUACCCAAA	UUUGGGUACUUAGCAUGCC		[1578-1596]
248	GAAUCAAUAGAAGAAGCUA	UAGCUUCUUCUAUUGAUUC		[1722-1740]
					249	GUAAAUAUAUCACCACUAU	AUAGUGGUGAUAUAUUUAC		[1035-1053]
250	CCUUAAAUCCUGAAACAGU	ACUGUUUCAGGAUUUAAGG		[987-1005]
					251	UCGAAAGAAUGGUGUCAAU	AUUGACACCAUUCUUUCGA		[1093-1111]
252	UAUGUAUUUGAGUGCAGAA	UUCUGCACUCAAAUACAUA		[1876-1894]
					253	CAACAACCAUGCUGGGCAU	AUGCCCAGCAUGGUUGUUG		[339-357]
254	CAUGAACCCAUGUUUGCAA	UUGCAAACAUGGGUUCAUG		[2273-2291]
					255	AACCUUAAAUCCUGAAACA	UGUUUCAGGAUUUAAGGUU		[985-1003]
256	CUAUCAUCCUCAAGGACAU	AUGUCCUUGAGGAUGAUAG		[1281-1299]
					257	GAGUCAUGACACUAAGUCA	UGACUUAGUGUCAUGACUC		[1059-1077]
258	GGUGAAGAGAAAGGAAGUA	UACUUCCUUUCUCUUCACC		[913-931]
					259	UUGAGUGCAGAAUUUAAAU	AUUUAAAUUCUGCACUCAA		[1883-1901]
260	CAGAAUACCAAGUGCAGAU	AUCUGCACUUGGUAUUCUG		[713-731]
					261	ACAUGGAAUCAUCAAGGAA	UUCCUUGAUGAUUCCAUGU		[796-814]
262	AAUAGAUGAGAUCAAGAAU	AUUCUUGAUCUCAUCUAUU		[1120-1138]
					263	GUGUAUGCAGAGGAUGAAA	UUUCAUCCUCUGCAUACAC		[1602-1620]
264	ACCUGGAACCACCUAAAGA	UCUUUAGGUGGUUCCAGGU		[2583-2601]
					265	AAUACUGCUUGGUUUUUUA	UAAAAAACCAAGCAGUAUU		[1427-1445]
266	AUUGAUUAAAGAUCUCAAA	UUUGAGAUCUUUAAUCAAU		[1225-1243]
					267	CAUGGAAUCAUCAAGGAAU	AUUCCUUGAUGAUUCCAUG		[797-815]
268	CCAAAAAAUACUUAAUAGU	ACUAUUAAGUAUUUUUUGG		[2168-2186]
					269	GGAUGUUUAAAAUCUAGUU	AACUAGAUUUUAAACAUCC		[1526-1544]
270	GAGCAGGAGAGUAUUACUA	UAGUAAUACUCUCCUGCUC		[2073-2091]

271	GUAGAUUUUUAAUAUCUCA	UGAGAUAUUAAAAAUCUAC		[1492-1510]
					272	UCUCCUUACUACUAUCCUA	UAGGAUAGUAGUAAGGAGA		[2460-2478]
273	ACUCUAUGAAUCAAUAGAA	UUCUAUUGAUUCAUAGAGU		[1715-1733]
					274	UGAGACUCAGAACUUGGAA	UUCCAAGUUCUGAGUCUCA		[478-496]
275	UGAGGGAAGCGGUUUACGA	UCGUAAACCGCUUCCCUCA		[168-186]
					276	GUAUGCAGAGGAUGAAAGA	UCUUUCAUCCUCUGCAUAC		[1604-1622]
277	CUCUAAAUUACCUCUGAUA	UAUCAGAGGUAAUUUAGAG		[1788-1806]
					278	GGAUGAAAGAUUAAGAUUA	UAAUCUUAAUCUUUCAUCC		[1613-1631]
279	CCAAGUGACUGACAUCAAC	GUUGAUGUCAGUCACUUGG		[421-439]
					280	UCUAAAUUACCUCUGAUAA	UUAUCAGAGGUAAUUUAGA		[1789-1807]
281	GCAUCAACUUCAUGGAAAG	CUUUCCAUGAAGUUGAUGC		[1189-1207]
					282	GGAACCACCUAAAGAACUU	AAGUUCUUUAGGUGGUUCC		[2587-2605]
283	AAGUUCAACUGCUUCGUAA	UUACGAAGCAGUUGAACUU		[1167-1185]
					284	UGACACUAAGUCAAGUUAA	UUAACUUGACUUAGUGUCA		[1065-1083]
285	AGUGUAUGCAGAGGAUGAA	UUCAUCCUCUGCAUACACU		[1601-1619]
					286	AGAUGUAAACCAAACUUUU	AAAAGUUUGGUUUACAUCU		[728-746]
287	UGAGAUCAAGAAUGACAAU	AUUGUCAUUCUUGAUCUCA		[1126-1144]
					288	AAAGCUUGGUCUAGAGUGA	UCACUCUAGACCAAGCUUU		[1341-1359]
289	CCUCAAGGACAUUACUAGU	ACUAGUAAUGUCCUUGAGG		[1288-1306]
					290	CAUGUAAAACCUGCUACAA	UUGUAGCAGGUUUUACAUG		[2353-2371]
291	CUUGCAGAGAAAAUUCAGA	UCUGAAUUUUCUCUGCAAG		[1262-1280]
					292	GAUUUUACCAUAUUUCUAA	UUAGAAAUAUGGUAAAAUC		[1815-1833]
293	GGAAGCGGUUUACGAGUGA	UCACUCGUAAACCGCUUCC		[172-190]
					294	UAUACAUAGCAAUGGUAAA	UUUACCAUUGCUAUGUAUA		[2381-2399]
295	GAUACCUGGAACCACCUAA	UUAGGUGGUUCCAGGUAUC		[2580-2598]
					296	GGCUCUACCUCAAAGACCU	AGGUCUUUGAGGUAGAGCC		[1904-1922]
297	GAAGUACAGAAAACAUGCA	UGCAUGUUUUCUGUACUUC		[926-944]

298	GCAUCAAAAGCAUUUUGAG	CUCAAAAUGCUUUUGAUGC		[2057-2075]
					299	CAACUCCAAGGGAUUGGAA	UUCCAAUCCCUUGGAGUUG		[436-454]
300	AAAUGUAAACUGUGAAGAU	AUCUUCACAGUUUACAUUU		[2544-2562]
					301	AAACUUCAUCAAGAGUAAA	UUUACUCUUGAUGAAGUUU		[1553-1571]
302	CUGGUUUGGAGAUACUAAC	GUUAGUAUCUCCAAACCAG		[2223-2241]
					303	AGAGAAAGUAGCUUUGUGA	UCACAAAGCUACUUUCUCU		[2249-2267]
304	UUCAGACUAUCAUCCUCAA	UUGAGGAUGAUAGUCUGAA		[1275-1293]
					305	UUGGGAAAACAAACUUCAU	AUGAAGUUUGUUUUCCCAA		[1543-1561]
306	AGGAAGGAUCCAGAUCUAA	UUAGAUCUGGAUCCUUCCU		[846-864]
					307	UCACCAAAAAAUACUUAAU	AUUAAGUAUUUUUUGGUGA		[2165-2183]
308	CCUCCAGGUGAAAGGAAAG	CUUUCCUUUCACCUGGAGG		[536-554]
					309	AAAAAUACUUAAUAGUCCA	UGGACUAUUAAGUAUUUUU		[2171-2189]
310	AGUGCAGAAUUUAAAUAAG	CUUAUUUAAAUUCUGCACU		[1886-1904]
					311	AGAAAAUUCAAACUUCAGA	UCUGAAGUUUGAAUUUUCU		[1312-1330]
312	UCAAUAAUGUCCCAUGUAA	UUACAUGGGACAUUAUUGA		[2341-2359]
					313	AAGGGAUUGGAAUUGAGGA	UCCUCAAUUCCAAUCCCUU		[443-461]
314	AUGAAUCUCCAACCUUAAA	UUUAAGGUUGGAGAUUCAU		[975-993]
					315	UAUAGGUAAAAGUACGUAA	UUACGUACUUUUACCUAUA		[2652-2670]
316	CUGGGUACAUUUUAUCAUU	AAUGAUAAAAUGUACCCAG		[1446-1464]
					317	AUAUGAUUCUGUAGUAUGA	UCAUACUACAGAAUCAUAU		[1648-1666]
318	ACCCUUGCACCAAAUGUGA	UCACAUUUGGUGCAAGGGU		[777-795]
					319	GGAAUUAUAAAAUAUAGGU	ACCUAUAUUUUAUAAUUCC		[2640-2658]
320	GAAUUCACAUAGAAAACAU	AUGUUUUCUAUGUGAAUUC		[1966-1984]
					321	AAAGAGGAAGGAUCCAGAU	AUCUGGAUCCUUCCUCUUU		[842-860]
322	CAAAGACCUUUGCACAGUU	AACUGUGCAAAGGUCUUUG		[1914-1932]
					323	AUUACUAGUGACUCAGAAA	UUUCUGAGUCACUAGUAAU		[1298-1316]
324	GAAUGUAAUCAGUGUAUGU	ACAUACACUGAUUACAUUC		[1665-1683]

325	AGAUUUUACCAUAUUUCUA	UAGAAAUAUGGUAAAAUCU		[1814-1832]
					326	GUGAAAAACAACAAAUUCA	UGAAUUUGUUGUUUUUCAC		[1356-1374]
327	UUCAGAAAUGAAAUCCAAA	UUUGGAUUUCAUUUCUGAA		[1325-1343]
					328	CCUAAAGAACUUCCAUUUA	UAAAUGGAAGUUCUUUAGG		[2594-2612]
329	CCUACUUCUUUCUCAGGCA	UGCCUGAGAAAGAAGUAGG		[2041-2059]
					330	CAAUUAGUGUUUGAAAAGA	UCUUUUCAAACACUAAUUG		[1389-1407]
331	AAAUAGGAGUGUAUGCAGA	UCUGCAUACACUCCUAUUU		[1594-1612]
					332	GAAAGUUUGUAUUAAAUGU	ACAUUUAAUACAAACUUUC		[2494-2512]
333	ACUUCAUGGAAAGAAAGAA	UUCUUUCUUUCCAUGAAGU		[1195-1213]
					334	ACAAUAUUUCAAUUGUGAA	UUCACAAUUGAAAUAUUGU		[1950-1968]
335	UGGAAGGCCUGCAUCAUGA	UCAUGAUGCAGGCCUUCCA		[492-510]
					336	UCCAAAUGCAGAAGAUGUA	UACAUCUUCUGCAUUUGGA		[641-659]
337	CCCAGAAUACCAAGUGCAG	CUGCACUUGGUAUUCUGGG	大鼠	[711-729]
					338	AUUGUGAAUUCACAUAGAA	UUCUAUGUGAAUUCACAAU		[1961-1979]
339	CUCCAACCUUAAAUCCUGA	UCAGGAUUUAAGGUUGGAG		[981-999]
					340	AAGAUAGUUAUAAACUGAA	UUCAGUUUAUAACUAUCUU		[2558-2576]
341	CAGAAAAUUCAAACUUCAG	CUGAAGUUUGAAUUUUCUG		[1311-1329]
					342	ACGUCUGUUGCUAGAUUAU	AUAAUCUAGCAACAGACGU		[383-401]
343	AGAUCAUAUUUAUGUAAAG	CUUUACAUAAAUAUGAUCU		[1855-1873]
					344	AGUUAUAAACUGAAGCAGA	UCUGCUUCAGUUUAUAACU		[2563-2581]
345	AUUGUUUGGGUGAAGAGAA	UUCUCUUCACCCAAACAAU		[905-923]
					346	GAACACUGUGACCCUUGCA	UGCAAGGGUCACAGUGUUC		[767-785]
347	CUGAUGUUGACUUGAGUAA	UUACUCAAGUCAACAUCAG		[1020-1038]
					348	GCAAUCAAAGAUGAUAAAA	UUUUAUCAUCUUUGAUUGC		[2288-2306]
349	AAACAAACUUCAUCAAGAG	CUCUUGAUGAAGUUUGUUU		[1549-1567]
					350	GGCUGUAAAUACUGCUUGG	CCAAGCAGUAUUUACAGCC		[1420-1438]
351	CAAGACUGCCCUUAGAAAU	AUUUCUAAGGGCAGUCUUG		[2198-2216]

352	AACAUAUGAUUCUGUAGUA	UACUACAGAAUCAUAUGUU		[1645-1663]
					353	CCAACCUUAAAUCCUGAAA	UUUCAGGAUUUAAGGUUGG		[983-1001]
354	GUGUUUGAAAAGAUUCUUA	UAAGAAUCUUUUCAAACAC		[1395-1413]
					355	AAAGGAAGUACAGAAAACA	UGUUUUCUGUACUUCCUUU		[922-940]
356	UUGCAAUCAAAGAUGAUAA	UUAUCAUCUUUGAUUGCAA		[2286-2304]
					357	AAAUCUAGUUGGGAAAACA	UGUUUUCCCAACUAGAUUU		[1535-1553]
358	UCAUGAUUCUGCCUCCAAG	CUUGGAGGCAGAAUCAUGA		[1508-1526]
					359	GAAGCUCUUUCACUUCGGA	UCCGAAGUGAAAGAGCUUC		[312-330]
360	CCAAGGGAUUGGAAUUGAG	CUCAAUUCCAAUCCCUUGG		[441-459]
					361	GGCUUUGUCUUCUUCUUUU	AAAAGAAGAAGACAAAGCC		[873-891]
362	AUAGGUAAAAGUACGUAAU	AUUACGUACUUUUACCUAU		[2653-2671]
					363	GUAAAAUCAUCAUCUGGAU	AUCCAGAUGAUGAUUUUAC		[2395-2413]
364	UGGAAAGAAAGAAGCGUAU	AUACGCUUCUUUCUUUCCA		[1201-1219]
					365	AUGUAAAACCUGCUACAAA	UUUGUAGCAGGUUUUACAU		[2354-2372]
366	GAUGUAAACCAAACUUUUU	AAAAAGUUUGGUUUACAUC		[729-747]
					367	AUGACCUUUUGCUGAAAUA	UAUUUCAGCAAAAGGUCAU		[1740-1758]
368	CCAACAUAUUUGUAGAUUU	AAAUCUACAAAUAUGUUGG		[1481-1499]
					369	UGCAGAAGAUGUAGAUUGU	ACAAUCUACAUCUUCUGCA		[647-665]
370	CAUCAAGAGUAAAUGCAGU	ACUGCAUUUACUCUUGAUG		[1559-1577]
					371	CACAUAGAAAACAUUAAAU	AUUUAAUGUUUUCUAUGUG		[1971-1989]
372	GCAACACCAAGUGCAAAGA	UCUUUGCACUUGGUGUUGC		[828-846]
					373	AGGUUCUCAUGAAUCUCCA	UGGAGAUUCAUGAGAACCU		[967-985]
374	CAAGAAGGGAAGGAGUACA	UGUACUCCUUCCCUUCUUG		[602-620]
					375	CACAGAAAGGAAAACCAAG	CUUGGUUUUCCUUUCUGUG		[950-968]
376	UUGUACUCUUGCAGAGAAA	UUUCUCUGCAAGAGUACAA		[1255-1273]
					377	CAAGGACAUUACUAGUGAC	GUCACUAGUAAUGUCCUUG		[1291-1309]
378	AGUUCAACUGCUUCGUAAU	AUUACGAAGCAGUUGAACU		[1168-1186]

379	AGUUCUGAGUAUAUGCAAU	AUUGCAUAUACUCAGAACU		[1374-1392]
					380	CUAUCCUACGUUUAAAUAU	AUAUUUAAACGUAGGAUAG		[2471-2489]
381	AGUUUAUUGGUGUCAUAUU	AAUAUGACACCAAUAAACU		[1929-1947]
					382	ACAUGCAGAAAGCACAGAA	UUCUGUGCUUUCUGCAUGU		[938-956]
383	GAAAUGAAAUCCAAAGCUU	AAGCUUUGGAUUUCAUUUC		[1329-1347]
					384	GAAAGGAAGUACAGAAAAC	GUUUUCUGUACUUCCUUUC		[921-939]
385	UACUUAAUAGUCCACCAAA	UUUGGUGGACUAUUAAGUA		[2176-2194]
					386	AUGUCUAUCCACAGGCUAA	UUAGCCUGUGGAUAGACAU		[1692-1710]
387	GAAUGCACACUCACCAGCA	UGCUGGUGAGUGUGCAUUC		[812-830]
					388	UUCUGUAGUAUGAAUGUAA	UUACAUUCAUACUACAGAA		[1654-1672]
389	CUUAGAAGUGGAAAUAAAC	GUUUAUUUCCACUUCUAAG		[682-700]
					390	UACUAGUGACUCAGAAAAU	AUUUUCUGAGUCACUAGUA		[1300-1318]
391	GAAGAGAAAGGAAGUACAG	CUGUACUUCCUUUCUCUUC		[916-934]
					392	AGUGUUAAUGCCCAAGUGA	UCACUUGGGCAUUAACACU		[410-428]
393	AGAGUGAAAAACAACAAAU	AUUUGUUGUUUUUCACUCU		[1353-1371]
					394	CAGUUUAUUGGUGUCAUAU	AUAUGACACCAAUAAACUG		[1928-1946]
395	AUGUUAGUACAAAUGUCUA	UAGACAUUUGUACUAACAU		[1680-1698]
					396	GGCAUCAAAAGCAUUUUGA	UCAAAAUGCUUUUGAUGCC		[2056-2074]
397	CACUCUAUGAAUCAAUAGA	UCUAUUGAUUCAUAGAGUG		[1714-1732]
					398	ACUAACUGCUCUCAGAGAA	UUCUCUGAGAGCAGUUAGU		[2236-2254]
399	CCCAAGUUUCUAAGAUUUA	UAAAUCUUAGAAACUUGGG		[2437-2455]
					400	AAGUUUGUAUUAAAUGUGA	UCACAUUUAAUACAAACUU		[2496-2514]
401	AAAUGCAGAAGAUGUAGAU	AUCUACAUCUUCUGCAUUU		[644-662]
					402	GAUUUUUAAUAUCUCAUGA	UCAUGAGAUAUUAAAAAUC		[1495-1513]
403	CCGAAAAUGUUCAAUAAUG	CAUUAUUGAACAUUUUCGG		[2331-2349]
					404	CAACAAAUUCAGUUCUGAG	CUCAGAACUGAAUUUGUUG		[1364-1382]
405	AAUACCAAGUGCAGAUGUA	UACAUCUGCACUUGGUAUU		[716-734]

406	AAGCUUGGUCUAGAGUGAA	UUCACUCUAGACCAAGCUU		[1342-1360]
					407	GAGUAAAUAUAUCACCACU	AGUGGUGAUAUAUUUACUC		[1033-1051]
408	GUGUUUGGAAUUAUAAAAU	AUUUUAUAAUUCCAAACAC		[2634-2652]
					409	AACCAAGGUUCUCAUGAAU	AUUCAUGAGAACCUUGGUU		[962-980]
410	AAAUCAUCAUCUGGAUUUA	UAAAUCCAGAUGAUGAUUU		[2398-2416]
					411	GGAAGACUGUUACUACAGU	ACUGUAGUAACAGUCUUCC		[459-477]
412	CCAAGGUUCUCAUGAAUCU	AGAUUCAUGAGAACCUUGG		[964-982]
					413	UUACUAGUGACUCAGAAAA	UUUUCUGAGUCACUAGUAA		[1299-1317]
414	UAGGGACUGCACAGUCAAU	AUUGACUGUGCAGUCCCUA		[556-574]
					415	CUCAUGAUUCUGCCUCCAA	UUGGAGGCAGAAUCAUGAG		[1507-1525]
416	CUAAAGAACUUCCAUUUAU	AUAAAUGGAAGUUCUUUAG		[2595-2613]
					417	UCAAACUUCAGAAAUGAAA	UUUCAUUUCUGAAGUUUGA		[1319-1337]
418	AUACCAAGUGCAGAUGUAA	UUACAUCUGCACUUGGUAU		[717-735]
					419	CAGGUGAAAGGAAAGCUAG	CUAGCUUUCCUUUCACCUG		[540-558]
420	CCAAAUGUGAACAUGGAAU	AUUCCAUGUUCACAUUUGG		[786-804]
					421	AUGUAAUCAGUGUAUGUUA	UAACAUACACUGAUUACAU		[1667-1685]
422	UGUUGACUUGAGUAAAUAU	AUAUUUACUCAAGUCAACA		[1024-1042]
					423	GUAACUCUACUGUAUGUGA	UCACAUACAGUAGAGUUAC		[750-768]
424	GUUUGCAAUCAAAGAUGAU	AUCAUCUUUGAUUGCAAAC		[2284-2302]
					425	GCUUAUACAUAGCAAUGGU	ACCAUUGCUAUGUAUAAGC		[2378-2396]
426	UGAGCAGGAGAGUAUUACU	AGUAAUACUCUCCUGCUCA		[2072-2090]
					427	CUUCUUUCUCAGGCAUCAA	UUGAUGCCUGAGAAAGAAG		[2045-2063]
428	UCUUUCUCAGGCAUCAAAA	UUUUGAUGCCUGAGAAAGA		[2047-2065]
					429	UUCACAUAGAAAACAUUAA	UUAAUGUUUUCUAUGUGAA		[1969-1987]
430	AAGUUUCUAAGAUUUAAGA	UCUUAAAUCUUAGAAACUU		[2440-2458]
					431	GACUGUUACUACAGUUGAG	CUCAACUGUAGUAACAGUC		[463-481]
432	ACUAGUGACUCAGAAAAUU	AAUUUUCUGAGUCACUAGU		[1301-1319]

433	CAAAUGCAGAAGAUGUAGA	UCUACAUCUUCUGCAUUUG		[643-661]
					434	CAAAUUCAGUUCUGAGUAU	AUACUCAGAACUGAAUUUG		[1367-1385]
435	GAAAAACAACAAAUUCAGU	ACUGAAUUUGUUGUUUUUC		[1358-1376]
					436	AGAAAAUUCAGACUAUCAU	AUGAUAGUCUGAAUUUUCU		[1269-1287]
437	GAUUAUCGUCCAAAAGUGU	ACACUUUUGGACGAUAAUC		[396-414]
					438	UAGGUAAAAGUACGUAAUU	AAUUACGUACUUUUACCUA		[2654-2672]
439	AAUGUAAACUGUGAAGAUA	UAUCUUCACAGUUUACAUU		[2545-2563]
					440	AUCACCAAAAAAUACUUAA	UUAAGUAUUUUUUGGUGAU		[2164-2182]
441	UCGUGAGCUCGUCUCUGAU	AUCAGAGACGAGCUCACGA		[103-121]
					442	CAAUAUUUCAAUUGUGAAU	AUUCACAAUUGAAAUAUUG		[1951-1969]
443	AGUUAAAGGCUUUGUUCGA	UCGAACAAAGCCUUUAACU		[1078-1096]
					444	GAAAGUAGCUUUGUGACAU	AUGUCACAAAGCUACUUUC		[2252-2270]
445	GUUUGACUAUUAUAUAUGU	ACAUAUAUAAUAGUCAAAC		[1996-2014]
					446	GAAAGCUAGGGACUGCACA	UGUGCAGUCCCUAGCUUUC		[550-568]
447	CACAGUUUAUUGGUGUCAU	AUGACACCAAUAAACUGUG		[1926-1944]
					448	CAUGUUUGCAAUCAAAGAU	AUCUUUGAUUGCAAACAUG		[2281-2299]
449	UGAGUGCAGAAUUUAAAUA	UAUUUAAAUUCUGCACUCA		[1884-1902]
					450	AAAACAUGCAGAAAGCACA	UGUGCUUUCUGCAUGUUUU		[935-953]
451	UACCUCUGAUAAUUCUAGA	UCUAGAAUUAUCAGAGGUA		[1796-1814]
					452	AAUUAGUGUUUGAAAAGAU	AUCUUUUCAAACACUAAUU		[1390-1408]
453	GUUUGUAUUAAAUGUGAAU	AUUCACAUUUAAUACAAAC		[2498-2516]
					454	AGACAAAGCCCAUUUUUCU	AGAAAAAUGGGCUUUGUCU		[622-640]
455	UACGUUUAAAUAUCUUUGA	UCAAAGAUAUUUAAACGUA		[2477-2495]
					456	AACAUGGAAUCAUCAAGGA	UCCUUGAUGAUUCCAUGUU		[795-813]
457	UGUUUGCAAUCAAAGAUGA	UCAUCUUUGAUUGCAAACA		[2283-2301]
					458	CCUCCUACCUCUGGUUCUU	AAGAACCAGAGGUAGGAGG		[364-382]
459	CUUUUUUUGUAACUCUACU	AGUAGAGUUACAAAAAAAG		[742-760]

460	UACAGAAAACAUGCAGAAA	UUUCUGCAUGUUUUCUGUA		[930-948]
					461	GUUAAAGGCUUUGUUCGAA	UUCGAACAAAGCCUUUAAC		[1079-1097]
462	ACAGAAAGUUCAACUGCUU	AAGCAGUUGAACUUUCUGU		[1162-1180]
					463	GAUGAGAUCAAGAAUGACA	UGUCAUUCUUGAUCUCAUC		[1124-1142]
464	GUCCUCCAGGUGAAAGGAA	UUCCUUUCACCUGGAGGAC		[534-552]
					465	AGUACAGAAAACAUGCAGA	UCUGCAUGUUUUCUGUACU		[928-946]
466	UAUCGUCCAAAAGUGUUAA	UUAACACUUUUGGACGAUA		[399-417]
					467	GGAUUUAGGAAUUGCUCUU	AAGAGCAAUUCCUAAAUCC		[2410-2428]
468	UAACUCUACUGUAUGUGAA	UUCACAUACAGUAGAGUUA		[751-769]
					469	CACAGACAAAGCCCAUUUU	AAAAUGGGCUUUGUCUGUG		[619-637]
470	AGUCAUGACACUAAGUCAA	UUGACUUAGUGUCAUGACU		[1060-1078]
					471	GUUGACUUGAGUAAAUAUA	UAUAUUUACUCAAGUCAAC		[1025-1043]
472	UUCAAACUUCAGAAAUGAA	UUCAUUUCUGAAGUUUGAA		[1318-1336]
					473	CAUUUAUGGAGGAUUUUUU	AAAAAAUCCUCCAUAAAUG		[2607-2625]
474	AAGAGAAAGGAAGUACAGA	UCUGUACUUCCUUUCUCUU		[917-935]
					475	CUAGAUUAUCGUCCAAAAG	CUUUUGGACGAUAAUCUAG		[393-411]
476	UCAGUGUAUGUUAGUACAA	UUGUACUAACAUACACUGA		[1673-1691]
					477	AAAAUUCAAACUUCAGAAA	UUUCUGAAGUUUGAAUUUU		[1314-1332]
478	CAACUUCAUGGAAAGAAAG	CUUUCUUUCCAUGAAGUUG		[1193-1211]
					479	ACUUCGGAGGAUUGCUCAA	UUGAGCAAUCCUCCGAAGU		[323-341]
480	ACAACAAAUUCAGUUCUGA	UCAGAACUGAAUUUGUUGU		[1363-1381]
					481	CAGAAAACAUGCAGAAAGC	GCUUUCUGCAUGUUUUCUG		[932-950]
482	CAUCCUCAAGGACAUUACU	AGUAAUGUCCUUGAGGAUG		[1285-1303]
					483	UGUUAGUACAAAUGUCUAU	AUAGACAUUUGUACUAACA		[1681-1699]
484	CUGUAUGUGAACACUGUGA	UCACAGUGUUCACAUACAG		[759-777]
					485	CCACUAAUUGUUUGGGUGA	UCACCCAAACAAUUAGUGG		[899-917]
486	AUCAUUUAUUAGCGCUGAA	UUCAGCGCUAAUAAAUGAU		[1459-1477]

487	AAACUGUGAAGAUAGUUAU	AUAACUAUCUUCACAGUUU		[2550-2568]
					488	GAGAUUUUACCAUAUUUCU	AGAAAUAUGGUAAAAUCUC		[1813-1831]
489	UUUCAAUUGUGAAUUCACA	UGUGAAUUCACAAUUGAAA		[1956-1974]
					490	UGUGACCCUUGCACCAAAU	AUUUGGUGCAAGGGUCACA		[773-791]
491	ACUACAGUUGAGACUCAGA	UCUGAGUCUCAACUGUAGU		[470-488]
					492	GAAUCAUCAAGGAAUGCAC	GUGCAUUCCUUGAUGAUUC		[801-819]
493	UGAUCUCGCGCAAGAGUGA	UCACUCUUGCGCGAGAUCA		[118-136]
					494	CAGGCAUCAAAAGCAUUUU	AAAAUGCUUUUGAUGCCUG		[2054-2072]
495	ACUGAAGCAGAUACCUGGA	UCCAGGUAUCUGCUUCAGU		[2571-2589]
					496	CAGAAAGGAAAACCAAGGU	ACCUUGGUUUUCCUUUCUG		[952-970]
497	GCAAUGGUAAAAUCAUCAU	AUGAUGAUUUUACCAUUGC		[2389-2407]
					498	GUGAAAGGAAAGCUAGGGA	UCCCUAGCUUUCCUUUCAC		[543-561]
499	CUGAAGCAGAUACCUGGAA	UUCCAGGUAUCUGCUUCAG		[2572-2590]
					500	AGUAAAUAUAUCACCACUA	UAGUGGUGAUAUAUUUACU		[1034-1052]

表B 17FASLG-Fas配位体(TNF超家族，成员6)

No.	正义链siRNA	反义链siRNA	其他Sp	人-4557328：158-1003
					1	CGGUGAAACUAACAGAUAA	UUAUCUGUUAGUUUCACCG		[1515-1533]
2	GAGGGAGAAGCAUGAAAAA	UUUUUCAUGCUUCUCCCUC		[1240-1258]
					3	CUCUAAUAGUGCUUAAAAA	UUUUUAAGCACUAUUAGAG		[1729-1747]
4	GGAUUUAAGGGAUGGAAAA	UUUUCCAUCCCUUAAAUCC		[1400-1418]
					5	GGAGGAAUAUGACGGAAGA	UCUUCCGUCAUAUUCCUCC		[1194-1212]
6	GCAUUUUUGUGAAAUGAAA	UUUCAUUUCACAAAAAUGC		[1809-1827]
					7	GGAGAAGCAUGAAAAAGCA	UGCUUUUUCAUGCUUCUCC		[1243-1261]
8	GCAGCAUCUUCACUUCUAA	UUAGAAGUGAAGAUGCUGC		[1478-1496]
					9	GGACUGAGAAGAAGUAAAA	UUUUACUUCUUCUCAGUCC		[104-122]
10	GGAAUAUGACGGAAGAACA	UGUUCUUCCGUCAUAUUCC		[1197-1215]

11	CGUUUUUCGGCUUAUAUAA	UUAUAUAAGCCGAAAAACG		[978-996]
					12	CAGUGAGGGUCUUCUUACA	UGUAAGAAGACCCUCACUG		[1067-1085]
13	CCAUUAUGAUUCUUUGUUA	UAACAAAGAAUCAUAAUGG		[1026-1044]
					14	CAACUCUAAUAGUGCUUAA	UUAAGCACUAUUAGAGUUG		[1726-1744]
15	CUAGAGGCUUGCAUAAUAA	UUAUUAUGCAAGCCUCUAG		[1425-1443]
					16	CGAGAAUGUUGUAUUCAGU	ACUGAAUACAACAUUCUCG		[1052-1070]
17	GAGGAAUAUGACGGAAGAA	UUCUUCCGUCAUAUUCCUC		[1195-1213]
					18	GGAUGUUUCAGCUCUUCCA	UGGAAGAGCUGAAACAUCC		[456-474]
19	CGGCUUAUAUAAGCUCUAA	UUAGAGCUUAUAUAAGCCG		[985-1003]
					20	GGACUCAUUUCAUUCCUAA	UUAGGAAUGAAAUGAGUCC		[1552-1570]
21	CAUUUUUGUGAAAUGAAAA	UUUUCAUUUCACAAAAAUG		[1810-1828]
					22	AGAGGGAGAAGCAUGAAAA	UUUUCAUGCUUCUCCCUCU		[1239-1257]
23	CUGGAGUGAAGUAUAAGAA	UUCUUAUACUUCACUCCAG	大鼠，Ms	[672-690]
					24	GGUUGCAUUUGGUCAAGAU	AUCUUGACCAAAUGCAACC		[1687-1705]
25	GAGUAUUUAGGCAGAUUGA	UCAAUCUGCCUAAAUACUC		[1297-1315]
					26	GAAACUAACAGAUAAGCAA	UUGCUUAUCUGUUAGUUUC		[1519-1537]
27	GAAUAUGACGGAAGAACAU	AUGUUCUUCCGUCAUAUUC		[1198-1216]
					28	CAGCAUCUUCACUUCUAAA	UUUAGAAGUGAAGAUGCUG		[1479-1497]
29	CCUCUUGAGCAGUCAGCAA	UUGCUGACUGCUCAAGAGG		[52-70]
					30	AGGAUUUAAGGGAUGGAAA	UUUCCAUCCCUUAAAUCCU		[1399-1417]
31	AGAUGUGCAUUUUUGUGAA	UUCACAAAAAUGCACAUCU		[1803-1821]
					32	GGACUGUCUUUCAGAUACA	UGUAUCUGAAAGACAGUCC		[1367-1385]
33	CCAGACAAAUGGAGGAAUA	UAUUCCUCCAUUUGUCUGG		[1184-1202]
					34	GAGGAUUUAAGGGAUGGAA	UUCCAUCCCUUAAAUCCUC		[1398-1416]
35	ACAGGCAAGUCCAACUCAA	UUGAGUUGGACUUGCCUGU		[605-623]
					36	GAGACCACAGGGUUCAAAA	UUUUGAACCCUGUGGUCUC		[1129-1147]
37	AGCUCUUCCACCUACAGAA	UUCUGUAGGUGGAAGAGCU		[465-483]

38	GGGACUCAUUUCAUUCCUA	UAGGAAUGAAAUGAGUCCC		[1551-1569]
					39	GUGAAAUGAAAACAUGUAA	UUACAUGUUUUCAUUUCAC		[1817-1835]
40	GGCCUUGUGAUCAAUGAAA	UUUCAUUGAUCACAAGGCC		[695-713]
					41	GCCUCUACAGGACUGAGAA	UUCUCAGUCCUGUAGAGGC		[95-113]
42	GGUUCUGGUUGCCUUGGUA	UACCAAGGCAACCAGAACC		[424-442]
					43	CAUUUGAGGUCAAGUAAGA	UCUUACUUGACCUCAAAUG		[1088-1106]
44	GUAUUUAGGCAGAUUGAAA	UUUCAAUCUGCCUAAAUAC		[1299-1317]
					45	GAAGAGGGAGAAGCAUGAA	UUCAUGCUUCUCCCUCUUC		[1237-1255]
46	AGACUAGAGGCUUGCAUAA	UUAUGCAAGCCUCUAGUCU		[1422-1440]
					47	GGAUGGAAAAGGAAGACUA	UAGUCUUCCUUUUCCAUCC		[1409-1427]
48	CCCUGAAGAAGAGAGGGAA	UUCCCUCUCUUCUUCAGGG		[366-384]
					49	AAGAGAGAAUGUAGAUAUU	AAUAUCUACAUUCUCUCUU		[1643-1661]
50	CCAGGUGUUCUACACUCAU	AUGAGUGUAGAACACCUGG		[1266-1284]
					51	ACUCUAAUAGUGCUUAAAA	UUUUAAGCACUAUUAGAGU		[1728-1746]
52	AGGACUGAGAAGAAGUAAA	UUUACUUCUUCUCAGUCCU		[103-121]
					53	GAUGUUUUCCUAUAAUAUA	UAUAUUAUAGGAAAACAUC		[1770-1788]
54	UAAUGAUGUUUUCCUAUAA	UUAUAGGAAAACAUCAUUA		[1766-1784]
					55	UGAAGUACAUAUUAGGAAA	UUUCCUAAUAUGUACUUCA		[1663-1681]
56	CAUGGUUGUGACCUGAGGA	UCCUCAGGUCACAACCAUG		[1384-1402]
					57	UUGUGACCUGAGGAUUUAA	UUAAAUCCUCAGGUCACAA		[1389-1407]
58	GACAAAUGGAGGAAUAUGA	UCAUAUUCCUCCAUUUGUC		[1187-1205]
					59	GACUGUCUUUCAGAUACAU	AUGUAUCUGAAAGACAGUC		[1368-1386]
60	AGCUAAAGAGGCUGAAAGA	UCUUUCAGCCUCUUUAGCU		[1443-1461]
					61	CAGUGCUGAUCAUUUAUAU	AUAUAAAUGAUCAGCACUG		[913-931]
62	GCAGCUACCAGGUGUUCUA	UAGAACACCUGGUAGCUGC		[1259-1277]
					63	UCUACAUGAGGAACUCUAA	UUAGAGUUCCUCAUGUAGA		[789-807]
64	GGGAUUCUUUCCAUUAUGA	UCAUAAUGGAAAGAAUCCC		[1016-1034]

65	AGACGUUUUUCGGCUUAUA	UAUAAGCCGAAAAACGUCU		[975-993]
					66	CCGAGAAUGUUGUAUUCAG	CUGAAUACAACAUUCUCGG		[1051-1069]
67	CUAUGGAAACUCUAUAAGA	UCUUAUAGAGUUUCCAUAG		[17-35]
					68	ACGUUUUUCGGCUUAUAUA	UAUAUAAGCCGAAAAACGU		[977-995]
69	CCCAGGAUCUGGUGAUGAU	AUCAUCACCAGAUCCUGGG		[813-831]
					70	AAUAGUGCUUAAAAAUCAU	AUGAUUUUUAAGCACUAUU		[1733-1751]
71	AAUGCUUCCUGACAAUCAA	UUGAUUGUCAGGAAGCAUU		[1710-1728]
					72	AAGGGAUGGAAAAGGAAGA	UCUUCCUUUUCCAUCCCUU		[1406-1424]
73	CAUGCAGCAGCCCUUCAAU	AUUGAAGGGCUGCUGCAUG		[157-175]
					74	GAGAGAAUGUAGAUAUUGU	ACAAUAUCUACAUUCUCUC		[1645-1663]
75	ACUAGAGGCUUGCAUAAUA	UAUUAUGCAAGCCUCUAGU		[1424-1442]
					76	UCCUGACAAUCAACUCUAA	UUAGAGUUGAUUGUCAGGA		[1716-1734]
77	UGAAAAGGACACCUUUUAA	UUAAAAGGUGUCCUUUUCA		[1313-1331]
					78	GAGGUGUUUCCCUUAGCUA	UAGCUAAGGGAAACACCUC		[1-19]
79	CAUCGGUGAAACUAACAGA	UCUGUUAGUUUCACCGAUG		[1512-1530]
					80	AUUUGGUCAAGAUUUUGAA	UUCAAAAUCUUGACCAAAU		[1693-1711]
81	CAACUCACCUAAUGUUUAU	AUAAACAUUAGGUGAGUUG		[1162-1180]
					82	CAGACAAAUGGAGGAAUAU	AUAUUCCUCCAUUUGUCUG		[1185-1203]
83	UGAAGAGGGAGAAGCAUGA	UCAUGCUUCUCCCUCUUCA		[1236-1254]
					84	CAGCAUCAUCUUUGGAGAA	UUCUCCAAAGAUGAUGCUG		[525-543]
85	AGCUAUGGAAACUCUAUAA	UUAUAGAGUUUCCAUAGCU		[15-33]
					86	AGGUGUUUCCCUUAGCUAU	AUAGCUAAGGGAAACACCU		[2-20]
87	GGGUUGCAUUUGGUCAAGA	UCUUGACCAAAUGCAACCC		[1686-1704]
					88	UGCAUUUGAGGUCAAGUAA	UUACUUGACCUCAAAUGCA		[1086-1104]
89	CACUCAUCUUAGUGCCUGA	UCAGGCACUAAGAUGAGUG		[1278-1296]
					90	CACAGUUCUUCCCUGUCCA	UGGACAGGGAAGAACUGUG		[238-256]
91	CAGGACUGAGAAGAAGUAA	UUACUUCUUCUCAGUCCUG		[102-120]

92	UGGGAAGACACCUAUGGAA	UUCCAUAGGUGUCUUCCCA		[641-659]
					93	GAAAUGAAAACAUGUAAUA	UAUUACAUGUUUUCAUUUC		[1819-1837]
94	CAUCUUUGGAGAAGCAAAU	AUUUGCUUCUCCAAAGAUG		[531-549]
					95	CUUUCUGGAGUGAAGUAUA	UAUACUUCACUCCAGAAAG		[668-686]
96	UAGAUAUUGUGAAGUACAU	AUGUACUUCACAAUAUCUA		[1654-1672]
					97	GCUCCUCAACUCACCUAAU	AUUAGGUGAGUUGAGGAGC		[1156-1174]
98	UGCAUUUUUGUGAAAUGAA	UUCAUUUCACAAAAAUGCA		[1808-1826]
					99	UCUGGAGUGAAGUAUAAGA	UCUUAUACUUCACUCCAGA	大鼠，Ms	[671-689]
100	GAUGUGCAUUUUUGUGAAA	UUUCACAAAAAUGCACAUC		[1804-1822]
					101	GGCAGCAUCUUCACUUCUA	UAGAAGUGAAGAUGCUGCC		[1477-1495]
102	UGAUGUUUUCCUAUAAUAU	AUAUUAUAGGAAAACAUCA		[1769-1787]
					103	AUGGGUUGCAUUUGGUCAA	UUGACCAAAUGCAACCCAU		[1684-1702]
104	AAGAGGGAGAAGCAUGAAA	UUUCAUGCUUCUCCCUCUU		[1238-1256]
					105	AGUAUUUAGGCAGAUUGAA	UUCAAUCUGCCUAAAUACU		[1298-1316]
106	CAGGCAAGUCCAACUCAAG	CUUGAGUUGGACUUGCCUG		[606-624]
					107	AAAAGUAUAUGUUAGGAUA	UAUCCUAACAUAUACUUUU		[1838-1856]
108	GACGUUUUUCGGCUUAUAU	AUAUAAGCCGAAAAACGUC		[976-994]
					109	GCUUGCAUAAUAAGCUAAA	UUUAGCUUAUUAUGCAAGC		[1431-1449]
110	AGAUAUUGUGAAGUACAUA	UAUGUACUUCACAAUAUCU		[1655-1673]
					111	CAUUGAUUGUCAGCUACUA	UAGUAGCUGACAAUCAAUG		[1749-1767]
112	GUAGAUAUUGUGAAGUACA	UGUACUUCACAAUAUCUAC		[1653-1671]
					113	GCUUAUAUAAGCUCUAAGA	UCUUAGAGCUUAUAUAAGC		[987-1005]
114	UUAAGGGAUGGAAAAGGAA	UUCCUUUUCCAUCCCUUAA		[1404-1422]
					115	GGAUUCUUUCCAUUAUGAU	AUCAUAAUGGAAAGAAUCC		[1017-1035]
116	AGUGCUUAAAAAUCAUUGA	UCAAUGAUUUUUAAGCACU		[1736-1754]
					117	UGACUAAAGAGAGAAUGUA	UACAUUCUCUCUUUAGUCA		[1637-1655]
118	GAUUGUCAGCUACUAAUGA	UCAUUAGUAGCUGACAAUC		[1753-1771]

119	CCUGCUUUCUGGAGUGAAG	CUUCACUCCAGAAAGCAGG		[664-682]
					120	UCUUGAGCAGUCAGCAACA	UGUUGCUGACUGCUCAAGA		[54-72]
121	UCAUCUUUGGAGAAGCAAA	UUUGCUUCUCCAAAGAUGA		[530-548]
					122	CAUGCCUCUGGAAUGGGAA	UUCCCAUUCCAGAGGCAUG		[628-646]
123	CAUUUAACAGGCAAGUCCA	UGGACUUGCCUGUUAAAUG		[599-617]
					124	GGAAAAUAUGGGUUGCAUU	AAUGCAACCCAUAUUUUCC		[1677-1695]
125	UUUCUGGAGUGAAGUAUAA	UUAUACUUCACUCCAGAAA		[669-687]
					126	AUGUGAAGAGGGAGAAGCA	UGCUUCUCCCUCUUCACAU		[1233-1251]
127	GGUGAAACUAACAGAUAAG	CUUAUCUGUUAGUUUCACC		[1516-1534]
					128	GCCCUUCAAUUACCCAUAU	AUAUGGGUAAUUGAAGGGC		[166-184]
129	AACAGAUAAGCAAGAGAGA	UCUCUCUUGCUUAUCUGUU		[1525-1543]
					130	ACAGUUCUUCCCUGUCCAA	UUGGACAGGGAAGAACUGU		[239-257]
131	AGGCUUGCAUAAUAAGCUA	UAGCUUAUUAUGCAAGCCU		[1429-1447]
					132	GGGUCUUCUUACAUGCAUU	AAUGCAUGUAAGAAGACCC		[1073-1091]
133	GAAGUACAUAUUAGGAAAA	UUUUCCUAAUAUGUACUUC		[1664-1682]
					134	UAUUGUGAAGUACAUAUUA	UAAUAUGUACUUCACAAUA		[1658-1676]
135	GCAGAACUCCGAGAGUCUA	UAGACUCUCGGAGUUCUGC		[491-509]
					136	ACAGGACUGAGAAGAAGUA	UACUUCUUCUCAGUCCUGU		[101-119]
137	UCUACAGGACUGAGAAGAA	UUCUUCUCAGUCCUGUAGA		[98-116]
					138	GAUGGAAAAGGAAGACUAG	CUAGUCUUCCUUUUCCAUC		[1410-1428]
139	UAAUAGUGCUUAAAAAUCA	UGAUUUUUAAGCACUAUUA		[1732-1750]
					140	GGAAGACACCUAUGGAAUU	AAUUCCAUAGGUGUCUUCC		[643-661]
141	CUUUGUAUAUUCCAAAGUA	UACUUUGGAAUAUACAAAG		[724-742]
					142	UACUAAUGAUGUUUUCCUA	UAGGAAAACAUCAUUAGUA		[1763-1781]
143	UAUUUAGGCAGAUUGAAAA	UUUUCAAUCUGCCUAAAUA		[1300-1318]
					144	GAGAAGAAGUAAAACCGUU	AACGGUUUUACUUCUUCUC		[109-127]
145	CUGAGCUCUCUCUGGUCAA	UUGACCAGAGAGAGCUCAG		[942-960]

146	GAUUGAAAAGGACACCUUU	AAAGGUGUCCUUUUCAAUC		[1310-1328]
					147	GUUGUGACCUGAGGAUUUA	UAAAUCCUCAGGUCACAAC		[1388-1406]
148	GGUUGUGACCUGAGGAUUU	AAAUCCUCAGGUCACAACC		[1387-1405]
					149	GGGCAGUGUUCAAUCUUAC	GUAAGAUUGAACACUGCCC		[894-912]
150	AACUCUAAUAGUGCUUAAA	UUUAAGCACUAUUAGAGUU		[1727-1745]
					151	AAGACUAGAGGCUUGCAUA	UAUGCAAGCCUCUAGUCUU		[1421-1439]
152	GUACUUUGUAUAUUCCAAA	UUUGGAAUAUACAAAGUAC		[721-739]
					153	GUUUCCCUUAGCUAUGGAA	UUCCAUAGCUAAGGGAAAC		[6-24]
154	UGUGAAAUGAAAACAUGUA	UACAUGUUUUCAUUUCACA		[1816-1834]
					155	AUGAUGUUUUCCUAUAAUA	UAUUAUAGGAAAACAUCAU		[1768-1786]
156	CCUUGUGAUCAAUGAAACU	AGUUUCAUUGAUCACAAGG		[697-715]
					157	CCUUUUAACUCACCUCUCA	UGAGAGGUGAGUUAAAAGG		[1324-1342]
158	UACCAGUGCUGAUCAUUUA	UAAAUGAUCAGCACUGGUA		[910-928]
					159	CAUCAUCUUUGGAGAAGCA	UGCUUCUCCAAAGAUGAUG		[528-546]
160	GAUUUUGAAUGCUUCCUGA	UCAGGAAGCAUUCAAAAUC		[1703-1721]
					161	GUGCAUUUUUGUGAAAUGA	UCAUUUCACAAAAAUGCAC		[1807-1825]
162	CUUUUAACUCACCUCUCAA	UUGAGAGGUGAGUUAAAAG		[1325-1343]
					163	AGACCACAGGGUUCAAAAU	AUUUUGAACCCUGUGGUCU		[1130-1148]
164	GAGAAUGUAGAUAUUGUGA	UCACAAUAUCUACAUUCUC		[1647-1665]
					165	AGUACAUAUUAGGAAAAUA	UAUUUUCCUAAUAUGUACU		[1666-1684]
166	AGGAUCUGGUGAUGAUGGA	UCCAUCAUCACCAGAUCCU		[816-834]
					167	CUAAAGAGAGAAUGUAGAU	AUCUACAUUCUCUCUUUAG		[1640-1658]
168	AAUGAUGUUUUCCUAUAAU	AUUAUAGGAAAACAUCAUU		[1767-1785]
					169	AAAAAAAGGAGCUGAGGAA	UUCCUCAGCUCCUUUUUUU		[573-591]
170	GACGGAAGAACAUAGAACU	AGUUCUAUGUUCUUCCGUC		[1204-1222]
					171	CUGAGAGUAUUUAGGCAGA	UCUGCCUAAAUACUCUCAG		[1293-1311]
172	GAAUGUAGAUAUUGUGAAG	CUUCACAAUAUCUACAUUC		[1649-1667]

173	AAUGGAGGAAUAUGACGGA	UCCGUCAUAUUCCUCCAUU		[1191-1209]
					174	UGUACUUUGUAUAUUCCAA	UUGGAAUAUACAAAGUACA		[720-738]
175	ACAGCAUCAUCUUUGGAGA	UCUCCAAAGAUGAUGCUGU		[524-542]
					176	GUGAAGUACAUAUUAGGAA	UUCCUAAUAUGUACUUCAC		[1662-1680]
177	CAAUCUUACCAGUGCUGAU	AUCAGCACUGGUAAGAUUG		[904-922]
					178	ACUAAAGAGAGAAUGUAGA	UCUACAUUCUCUCUUUAGU		[1639-1657]
179	CAGCUCUUCCACCUACAGA	UCUGUAGGUGGAAGAGCUG		[464-482]
					180	CUUAGCUAUGGAAACUCUA	UAGAGUUUCCAUAGCUAAG		[12-30]
181	UGGAGUGAAGUAUAAGAAG	CUUCUUAUACUUCACUCCA		[673-691]
					182	GUACAUAUUAGGAAAAUAU	AUAUUUUCCUAAUAUGUAC		[1667-1685]
183	UAUAUAAGCUCUAAGAGAA	UUCUCUUAGAGCUUAUAUA		[990-1008]
					184	AAGUCCAACUCAAGGUCCA	UGGACCUUGAGUUGGACUU		[611-629]
185	UGUGAAGUACAUAUUAGGA	UCCUAAUAUGUACUUCACA		[1661-1679]
					186	GCUGAUCAUUUAUAUGUCA	UGACAUAUAAAUGAUCAGC		[917-935]
187	UGAAGAAGAGAGGGAACCA	UGGUUCCCUCUCUUCUUCA		[369-387]
					188	CAUUUAUAUGUCAACGUAU	AUACGUUGACAUAUAAAUG		[923-941]
189	AGAAUGUAGAUAUUGUGAA	UUCACAAUAUCUACAUUCU		[1648-1666]
					190	AUGACGGAAGAACAUAGAA	UUCUAUGUUCUUCCGUCAU		[1202-1220]
191	UCAAGUAAGAAGACAUGAA	UUCAUGUCUUCUUACUUGA		[1097-1115]
					192	GUAAGAAGACAUGAACCAA	UUGGUUCAUGUCUUCUUAC		[1101-1119]
193	GACUAAAGAGAGAAUGUAG	CUACAUUCUCUCUUUAGUC		[1638-1656]
					194	GGAAGACUAGAGGCUUGCA	UGCAAGCCUCUAGUCUUCC		[1419-1437]
195	GAUAUUGUGAAGUACAUAU	AUAUGUACUUCACAAUAUC		[1656-1674]
					196	CCUCAACUCACCUAAUGUU	AACAUUAGGUGAGUUGAGG		[1159-1177]
197	CAUUUGGUCAAGAUUUUGA	UCAAAAUCUUGACCAAAUG		[1692-1710]
					198	UCUAAUAGUGCUUAAAAAU	AUUUUUAAGCACUAUUAGA		[1730-1748]
199	AUUUAACAGGCAAGUCCAA	UUGGACUUGCCUGUUAAAU		[600-618]

200	GGAAUGGGAAGACACCUAU	AUAGGUGUCUUCCCAUUCC		[637-655]
					201	UGGGCUGUACUUUGUAUAU	AUAUACAAAGUACAGCCCA		[715-733]
202	GGAAGAACAUAGAACUCUG	CAGAGUUCUAUGUUCUUCC		[1207-1225]
					203	CUGACAAUCAACUCUAAUA	UAUUAGAGUUGAUUGUCAG		[1718-1736]
204	CUAAUGAUGUUUUCCUAUA	UAUAGGAAAACAUCAUUAG		[1765-1783]
					205	CUGGGCUGUACUUUGUAUA	UAUACAAAGUACAGCCCAG		[714-732]
206	GGGAAGACACCUAUGGAAU	AUUCCAUAGGUGUCUUCCC		[642-660]
					207	UGAGGAUUUAAGGGAUGGA	UCCAUCCCUUAAAUCCUCA		[1397-1415]
208	AGUGGACCUUGAGACCACA	UGUGGUCUCAAGGUCCACU		[1119-1137]
					209	AUGCAUUUGAGGUCAAGUA	UACUUGACCUCAAAUGCAU		[1085-1103]
210	UGAUGUUUUUCAUGGUUCU	AGAACCAUGAAAAACAUCA		[411-429]
					211	GAGGGUCUUCUUACAUGCA	UGCAUGUAAGAAGACCCUC		[1071-1089]
212	UAUUUCCAGUGCAAUUGUA	UACAAUUGCACUGGAAAUA		[1582-1600]
					213	ACCUGAGGAUUUAAGGGAU	AUCCCUUAAAUCCUCAGGU		[1394-1412]
214	GAAAAAAAGGAGCUGAGGA	UCCUCAGCUCCUUUUUUUC		[572-590]
					215	GAACCAAGUGGACCUUGAG	CUCAAGGUCCACUUGGUUC		[1113-1131]
216	CCAGUGCUGAUCAUUUAUA	UAUAAAUGAUCAGCACUGG		[912-930]
					217	ACAUGAGGAACUCUAAGUA	UACUUAGAGUUCCUCAUGU		[792-810]
218	AGCUCCUCAACUCACCUAA	UUAGGUGAGUUGAGGAGCU		[1155-1173]
					219	GCCUGAGAGUAUUUAGGCA	UGCCUAAAUACUCUCAGGC		[1291-1309]
220	CUAACAGAUAAGCAAGAGA	UCUCUUGCUUAUCUGUUAG		[1523-1541]
					221	UGCAUUUGGUCAAGAUUUU	AAAAUCUUGACCAAAUGCA		[1690-1708]
222	CAUUAUGAUUCUUUGUUAC	GUAACAAAGAAUCAUAAUG		[1027-1045]
					223	ACAAGGUCUACAUGAGGAA	UUCCUCAUGUAGACCUUGU		[783-801]
224	GUUCUACACUCAUCUUAGU	ACUAAGAUGAGUGUAGAAC		[1272-1290]
					225	AGCCCUUCAAUUACCCAUA	UAUGGGUAAUUGAAGGGCU		[165-183]
226	AUGUAGAUAUUGUGAAGUA	UACUUCACAAUAUCUACAU		[1651-1669]

227	UCGGUGAAACUAACAGAUA	UAUCUGUUAGUUUCACCGA		[1514-1532]
					228	AUUUGAGGUCAAGUAAGAA	UUCUUACUUGACCUCAAAU		[1089-1107]
229	AGUCCAACUCAAGGUCCAU	AUGGACCUUGAGUUGGACU		[612-630]
					230	GGUGUUCUACACUCAUCUU	AAGAUGAGUGUAGAACACC		[1269-1287]
231	UCUGGUCAAUUUUGAGGAA	UUCCUCAAAAUUGACCAGA		[952-970]
					232	GUGCUUAAAAAUCAUUGAU	AUCAAUGAUUUUUAAGCAC		[1737-1755]
233	UAGCUAUGGAAACUCUAUA	UAUAGAGUUUCCAUAGCUA		[14-32]
					234	AGGCACCGAGAAUGUUGUA	UACAACAUUCUCGGUGCCU		[1046-1064]
235	CAUGAAAAAGCAGCUACCA	UGGUAGCUGCUUUUUCAUG		[1250-1268]
					236	CCAUGUGAAGAGGGAGAAG	CUUCUCCCUCUUCACAUGG		[1231-1249]
237	UGAAAUGAAAACAUGUAAU	AUUACAUGUUUUCAUUUCA		[1818-1836]
					238	AAGAAGAGAGGGAACCACA	UGUGGUUCCCUCUCUUCUU		[371-389]
239	CUUUCAGAUACAUGGUUGU	ACAACCAUGUAUCUGAAAG		[1374-1392]
					240	CAAUUUUGAGGAAUCUCAG	CUGAGAUUCCUCAAAAUUG		[958-976]
241	UGAACCAAGUGGACCUUGA	UCAAGGUCCACUUGGUUCA		[1112-1130]
					242	UCAUUUAUAUGUCAACGUA	UACGUUGACAUAUAAAUGA		[922-940]
243	GCAUUUGAGGUCAAGUAAG	CUUACUUGACCUCAAAUGC		[1087-1105]
					244	GGGCUGUACUUUGUAUAUU	AAUAUACAAAGUACAGCCC		[716-734]
245	AUGGAAACUCUAUAAGAGA	UCUCUUAUAGAGUUUCCAU		[19-37]
					246	AGGCAGAUUGAAAAGGACA	UGUCCUUUUCAAUCUGCCU		[1305-1323]
247	CAUGAGGAACUCUAAGUAU	AUACUUAGAGUUCCUCAUG		[793-811]
					248	ACUCUAUAAGAGAGAUCCA	UGGAUCUCUCUUAUAGAGU		[25-43]
249	CACCGAGAAUGUUGUAUUC	GAAUACAACAUUCUCGGUG		[1049-1067]
					250	AUGGAAAAGGAAGACUAGA	UCUAGUCUUCCUUUUCCAU		[1411-1429]
251	UUUAAGGGAUGGAAAAGGA	UCCUUUUCCAUCCCUUAAA		[1403-1421]
					252	AGAAGGCCUGGUCAAAGGA	UCCUUUGACCAGGCCUUCU		[269-287]
253	UUGUAUAUUCCAAAGUAUA	UAUACUUUGGAAUAUACAA		[726-744]

254	CACAAGGUCUACAUGAGGA	UCCUCAUGUAGACCUUGUG		[782-800]
					255	GGGUCAAUCUUGCAACAAC	GUUGUUGCAAGAUUGACCC		[751-769]
256	GGAGUGAAGUAUAAGAAGG	CCUUCUUAUACUUCACUCC		[674-692]
					257	GUGUAUUUCCAGUGCAAUU	AAUUGCACUGGAAAUACAC		[1579-1597]
258	AAUUUUGAGGAAUCUCAGA	UCUGAGAUUCCUCAAAAUU		[959-977]
					259	AAUUGUCCUGCUUUCUGGA	UCCAGAAAGCAGGACAAUU		[658-676]
260	GAAAACAUGUAAUAAAAAG	CUUUUUAUUACAUGUUUUC		[1824-1842]
					261	AAGGUCCAUGCCUCUGGAA	UUCCAGAGGCAUGGACCUU		[622-640]
262	GUCUCCUUGUGAUGUUUUU	AAAAACAUCACAAGGAGAC		[402-420]
					263	GGAAACUCUAUAAGAGAGA	UCUCUCUUAUAGAGUUUCC		[21-39]
264	GGGAGAAGCAUGAAAAAGC	GCUUUUUCAUGCUUCUCCC		[1242-1260]
					265	AUGGAGGAAUAUGACGGAA	UUCCGUCAUAUUCCUCCAU		[1192-1210]
266	AUGGGAAGACACCUAUGGA	UCCAUAGGUGUCUUCCCAU		[640-658]
					267	AGAAUGUUGUAUUCAGUGA	UCACUGAAUACAACAUUCU		[1054-1072]
268	GUCAGCUACUAAUGAUGUU	AACAUCAUUAGUAGCUGAC		[1757-1775]
					269	CUUCACUUCUAAAUGCAUA	UAUGCAUUUAGAAGUGAAG		[1485-1503]
270	AGGUCAAGUAAGAAGACAU	AUGUCUUCUUACUUGACCU		[1094-1112]
					271	UGUAGAUGUGCAUUUUUGU	ACAAAAAUGCACAUCUACA		[1800-1818]
272	GAUUCUUUCCAUUAUGAUU	AAUCAUAAUGGAAAGAAUC		[1018-1036]
					273	CUGAUCAUUUAUAUGUCAA	UUGACAUAUAAAUGAUCAG		[918-936]
274	AGGAAAAUAUGGGUUGCAU	AUGCAACCCAUAUUUUCCU		[1676-1694]
					275	UGUGAAGAGGGAGAAGCAU	AUGCUUCUCCCUCUUCACA		[1234-1252]
276	GAGGAAUCUCAGACGUUUU	AAAACGUCUGAGAUUCCUC		[965-983]
					277	UCCUUGUGAUGUUUUUCAU	AUGAAAAACAUCACAAGGA		[405-423]
278	GGCUUGCAUAAUAAGCUAA	UUAGCUUAUUAUGCAAGCC		[1430-1448]
					279	UUAGGCAGAUUGAAAAGGA	UCCUUUUCAAUCUGCCUAA		[1303-1321]
280	GUUGCAUUUGGUCAAGAUU	AAUCUUGACCAAAUGCAAC		[1688-1706]

281	CAGAUCUACUGGGUGGACA	UGUCCACCCAGUAGAUCUG		[188-206]
					282	GAAAAUAUGGGUUGCAUUU	AAAUGCAACCCAUAUUUUC		[1678-1696]
283	CCUGACAAUCAACUCUAAU	AUUAGAGUUGAUUGUCAGG		[1717-1735]
					284	CAACGUAUCUGAGCUCUCU	AGAGAGCUCAGAUACGUUG		[934-952]
285	AACUAACAGAUAAGCAAGA	UCUUGCUUAUCUGUUAGUU		[1521-1539]
					286	GAGAGUAUUUAGGCAGAUU	AAUCUGCCUAAAUACUCUC		[1295-1313]
287	CCUCUGGAAUGGGAAGACA	UGUCUUCCCAUUCCAGAGG	大鼠，Ms	[632-650]
					288	CAAUGAAACUGGGCUGUAC	GUACAGCCCAGUUUCAUUG		[706-724]
289	UGCUUUCUGGAGUGAAGUA	UACUUCACUCCAGAAAGCA		[666-684]
					290	UAAGCUAAAGAGGCUGAAA	UUUCAGCCUCUUUAGCUUA		[1441-1459]
291	AGAAGAAGUAAAACCGUUU	AAACGGUUUUACUUCUUCU		[110-128]
					292	UGAGAAGAAGUAAAACCGU	ACGGUUUUACUUCUUCUCA		[108-126]
293	UCAGAUACAUGGUUGUGAC	GUCACAACCAUGUAUCUGA		[1377-1395]
					294	GAAACUCUAUAAGAGAGAU	AUCUCUCUUAUAGAGUUUC		[22-40]
295	GGUCAAUUUUGAGGAAUCU	AGAUUCCUCAAAAUUGACC		[955-973]
					296	UGCAGCAGCCCUUCAAUUA	UAAUUGAAGGGCUGCUGCA		[159-177]
297	CUAUGGAAUUGUCCUGCUU	AAGCAGGACAAUUCCAUAG		[652-670]
					298	GGCUGUACUUUGUAUAUUC	GAAUAUACAAAGUACAGCC		[717-735]
299	UCGGCUUAUAUAAGCUCUA	UAGAGCUUAUAUAAGCCGA		[984-1002]
					300	CAGACGUUUUUCGGCUUAU	AUAAGCCGAAAAACGUCUG		[974-992]
301	ACCAGGUGUUCUACACUCA	UGAGUGUAGAACACCUGGU		[1265-1283]
					302	AAGACAUGAACCAAGUGGA	UCCACUUGGUUCAUGUCUU		[1106-1124]
303	UUGGGAUUCUUUCCAUUAU	AUAAUGGAAAGAAUCCCAA		[1014-1032]
					304	AGAUCUACUGGGUGGACAG	CUGUCCACCCAGUAGAUCU		[189-207]
305	AUUGAUUGUCAGCUACUAA	UUAGUAGCUGACAAUCAAU		[1750-1768]
					306	CUUCUUACAUGCAUUUGAG	CUCAAAUGCAUGUAAGAAG		[1077-1095]
307	GCAGCAGCCCUUCAAUUAC	GUAAUUGAAGGGCUGCUGC		[160-178]

308	UGGAAUGGGAAGACACCUA	UAGGUGUCUUCCCAUUCCA		[636-654]
					309	CCUGAAGAAGAGAGGGAAC	GUUCCCUCUCUUCUUCAGG		[367-385]
310	UACAUGCAUUUGAGGUCAA	UUGACCUCAAAUGCAUGUA		[1082-1100]
					311	CUGUACUUUGUAUAUUCCA	UGGAAUAUACAAAGUACAG		[719-737]
312	GCAGCCCUUCAAUUACCCA	UGGGUAAUUGAAGGGCUGC		[163-181]
					313	UGUUUCCCUUAGCUAUGGA	UCCAUAGCUAAGGGAAACA		[5-23]
314	CAGGCACCGAGAAUGUUGU	ACAACAUUCUCGGUGCCUG		[1045-1063]
					315	CAUGCAUUUGAGGUCAAGU	ACUUGACCUCAAAUGCAUG		[1084-1102]
316	CAGGGUUCAAAAUGUCUGU	ACAGACAUUUUGAACCCUG		[1136-1154]
					317	UCAACUCACCUAAUGUUUA	UAAACAUUAGGUGAGUUGA		[1161-1179]
318	AACUGGGCUGUACUUUGUA	UACAAAGUACAGCCCAGUU		[712-730]
					319	UGAAACUAACAGAUAAGCA	UGCUUAUCUGUUAGUUUCA		[1518-1536]
320	GAAGCAUGAAAAAGCAGCU	AGCUGCUUUUUCAUGCUUC		[1246-1264]
					321	UAUGACGGAAGAACAUAGA	UCUAUGUUCUUCCGUCAUA		[1201-1219]
322	AAUCAUUGAUUGUCAGCUA	UAGCUGACAAUCAAUGAUU		[1746-1764]
					323	AGCUCUCUCUGGUCAAUUU	AAAUUGACCAGAGAGAGCU		[945-963]
324	CUUGCAUAAUAAGCUAAAG	CUUUAGCUUAUUAUGCAAG		[1432-1450]
					325	GAAGCACUUUGGGAUUCUU	AAGAAUCCCAAAGUGCUUC		[1006-1024]
326	AAAGAGAGAAUGUAGAUAU	AUAUCUACAUUCUCUCUUU		[1642-1660]
					327	GGUCAAGAUUUUGAAUGCU	AGCAUUCAAAAUCUUGACC		[1697-1715]
328	GUCUACAUGAGGAACUCUA	UAGAGUUCCUCAUGUAGAC		[788-806]
					329	GAGGUCAAGUAAGAAGACA	UGUCUUCUUACUUGACCUC		[1093-1111]
330	CAGCUACUAAUGAUGUUUU	AAAACAUCAUUAGUAGCUG		[1759-1777]
					331	UAGGCAGAUUGAAAAGGAC	GUCCUUUUCAAUCUGCCUA		[1304-1322]
332	GGCCCAUUUAACAGGCAAG	CUUGCCUGUUAAAUGGGCC		[595-613]
					333	GAGUGAAGUAUAAGAAGGG	CCCUUCUUAUACUUCACUC		[675-693]
334	ACCAGUGCUGAUCAUUUAU	AUAAAUGAUCAGCACUGGU		[911-929]

335	GCCUUGUGAUCAAUGAAAC	GUUUCAUUGAUCACAAGGC		[696-714]
					336	AGAGAAUGUAGAUAUUGUG	CACAAUAUCUACAUUCUCU		[1646-1664]
337	CUCCUUGUGAUGUUUUUCA	UGAAAAACAUCACAAGGAG		[404-422]
					338	GAAGUAAAACCGUUUGCUG	CAGCAAACGGUUUUACUUC		[114-132]
339	GAAGACUAGAGGCUUGCAU	AUGCAAGCCUCUAGUCUUC		[1420-1438]
					340	CCUUAGCUAUGGAAACUCU	AGAGUUUCCAUAGCUAAGG		[11-29]
341	AGCUCUAAGAGAAGCACUU	AAGUGCUUCUCUUAGAGCU		[996-1014]
					342	UUGUUACAGGCACCGAGAA	UUCUCGGUGCCUGUAACAA		[1039-1057]
343	UUGAGACCACAGGGUUCAA	UUGAACCCUGUGGUCUCAA		[1127-1145]
					344	AAUGUCUGUAGCUCCUCAA	UUGAGGAGCUACAGACAUU		[1146-1164]
345	AAAAAAGGAGCUGAGGAAA	UUUCCUCAGCUCCUUUUUU		[574-592]
					346	CUACAUGAGGAACUCUAAG	CUUAGAGUUCCUCAUGUAG		[790-808]
347	CUUUGGGAUUCUUUCCAUU	AAUGGAAAGAAUCCCAAAG		[1012-1030]
					348	AACCAAGUGGACCUUGAGA	UCUCAAGGUCCACUUGGUU		[1114-1132]
349	UGUUUUUCAUGGUUCUGGU	ACCAGAACCAUGAAAAACA		[414-432]
					350	AGAAGAGAGGGAACCACAG	CUGUGGUUCCCUCUCUUCU		[372-390]
351	AUGGUUGUGACCUGAGGAU	AUCCUCAGGUCACAACCAU		[1385-1403]
					352	GGCUUAUAUAAGCUCUAAG	CUUAGAGCUUAUAUAAGCC		[986-1004]
353	UUUGAAUGCUUCCUGACAA	UUGUCAGGAAGCAUUCAAA		[1706-1724]
					354	GAAUGUUGUAUUCAGUGAG	CUCACUGAAUACAACAUUC		[1055-1073]
355	GACUAGAGGCUUGCAUAAU	AUUAUGCAAGCCUCUAGUC		[1423-1441]
					356	GGUGUUUCCCUUAGCUAUG	CAUAGCUAAGGGAAACACC		[3-21]
357	CCUGAAAAAAAGGAGCUGA	UCAGCUCCUUUUUUUCAGG		[569-587]
					358	GACUCAUUUCAUUCCUAAC	GUUAGGAAUGAAAUGAGUC		[1553-1571]
359	GACAAUCAACUCUAAUAGU	ACUAUUAGAGUUGAUUGUC		[1720-1738]
					360	GGAAGAUGAUGAGCUACUG	CAGUAGCUCAUCAUCUUCC		[837-855]
361	AAAUGUCUGUAGCUCCUCA	UGAGGAGCUACAGACAUUU		[1145-1163]

362	GGCAGAUUGAAAAGGACAC	GUGUCCUUUUCAAUCUGCC		[1306-1324]
					363	GUUUCAGCUCUUCCACCUA	UAGGUGGAAGAGCUGAAAC		[460-478]
364	GACCUGAGGAUUUAAGGGA	UCCCUUAAAUCCUCAGGUC		[1393-1411]
					365	UUAUAUAAGCUCUAAGAGA	UCUCUUAGAGCUUAUAUAA		[989-1007]
366	ACUGGGCUGUACUUUGUAU	AUACAAAGUACAGCCCAGU		[713-731]
					367	GUAUUUCCAGUGCAAUUGU	ACAAUUGCACUGGAAAUAC		[1581-1599]
368	GUGUUCUACACUCAUCUUA	UAAGAUGAGUGUAGAACAC		[1270-1288]
					369	UAAGCAAGAGAGAUGUUUU	AAAACAUCUCUCUUGCUUA		[1531-1549]
370	CAAAAUGUCUGUAGCUCCU	AGGAGCUACAGACAUUUUG		[1143-1161]
					371	CUGCUUUCUGGAGUGAAGU	ACUUCACUCCAGAAAGCAG		[665-683]
372	GAAUGCUUCCUGACAAUCA	UGAUUGUCAGGAAGCAUUC		[1709-1727]
					373	GCUUAAAAAUCAUUGAUUG	CAAUCAAUGAUUUUUAAGC		[1739-1757]
374	CAGCCCUUCAAUUACCCAU	AUGGGUAAUUGAAGGGCUG		[164-182]
					375	UCCUCUUGAGCAGUCAGCA	UGCUGACUGCUCAAGAGGA		[51-69]
376	GGGACUGUCUUUCAGAUAC	GUAUCUGAAAGACAGUCCC		[1366-1384]
					377	UAUGGAAACUCUAUAAGAG	CUCUUAUAGAGUUUCCAUA		[18-36]
378	UGAGAGUAUUUAGGCAGAU	AUCUGCCUAAAUACUCUCA		[1294-1312]
					379	CCAUCGGUGAAACUAACAG	CUGUUAGUUUCACCGAUGG		[1511-1529]
380	UUGCAUAAUAAGCUAAAGA	UCUUUAGCUUAUUAUGCAA		[1433-1451]
					381	UCUCUCUGGUCAAUUUUGA	UCAAAAUUGACCAGAGAGA		[948-966]
382	GACUGAGAAGAAGUAAAAC	GUUUUACUUCUUCUCAGUC		[105-123]
					383	AUGAUGAGCUACUGCACUA	UAGUGCAGUAGCUCAUCAU		[842-860]
384	GCACCGAGAAUGUUGUAUU	AAUACAACAUUCUCGGUGC		[1048-1066]
					385	UGUGAUCAAUGAAACUGGG	CCCAGUUUCAUUGAUCACA		[700-718]
386	CUGAAAAAAAGGAGCUGAG	CUCAGCUCCUUUUUUUCAG		[570-588]
					387	GUGACCUGAGGAUUUAAGG	CCUUAAAUCCUCAGGUCAC		[1391-1409]
388	GAACUCCGAGAGUCUACCA	UGGUAGACUCUCGGAGUUC		[494-512]

389	GAAAAAGCAGCUACCAGGU	ACCUGGUAGCUGCUUUUUC		[1253-1271]
					390	UUUGUAUAUUCCAAAGUAU	AUACUUUGGAAUAUACAAA		[725-743]
391	UGAGCUCUCUCUGGUCAAU	AUUGACCAGAGAGAGCUCA		[943-961]
					392	UUUGGUCAAGAUUUUGAAU	AUUCAAAAUCUUGACCAAA		[1694-1712]
393	AGGUGUUCUACACUCAUCU	AGAUGAGUGUAGAACACCU		[1268-1286]
					394	GAUAAGCAAGAGAGAUGUU	AACAUCUCUCUUGCUUAUC		[1529-1547]
395	AUACAUGGUUGUGACCUGA	UCAGGUCACAACCAUGUAU		[1381-1399]
					396	CACUUUGGGAUUCUUUCCA	UGGAAAGAAUCCCAAAGUG		[1010-1028]
397	AAGAAGACAUGAACCAAGU	ACUUGGUUCAUGUCUUCUU		[1103-1121]
					398	AUCGGUGAAACUAACAGAU	AUCUGUUAGUUUCACCGAU		[1513-1531]
399	GGUCAAGUAAGAAGACAUG	CAUGUCUUCUUACUUGACC		[1095-1113]
					400	AGGGUCUUCUUACAUGCAU	AUGCAUGUAAGAAGACCCU		[1072-1090]
401	UUGUGAAAUGAAAACAUGU	ACAUGUUUUCAUUUCACAA		[1815-1833]
					402	UGAGACCACAGGGUUCAAA	UUUGAACCCUGUGGUCUCA		[1128-1146]
403	GAGGCUUGCAUAAUAAGCU	AGCUUAUUAUGCAAGCCUC		[1428-1446]
					404	UCUUCCACCUACAGAAGGA	UCCUUCUGUAGGUGGAAGA		[468-486]
405	ACUUCUAAAUGCAUAUCCU	AGGAUAUGCAUUUAGAAGU		[1489-1507]
					406	AGUGAAGUAUAAGAAGGGU	ACCCUUCUUAUACUUCACU		[676-694]
407	CUCACCUAAUGUUUAUGAG	CUCAUAAACAUUAGGUGAG		[1165-1183]
					408	GUUCUUCCCUGUCCAACCU	AGGUUGGACAGGGAAGAAC		[242-260]
409	AUGACUAAAGAGAGAAUGU	ACAUUCUCUCUUUAGUCAU		[1636-1654]
					410	AUUGUCAGCUACUAAUGAU	AUCAUUAGUAGCUGACAAU		[1754-1772]
411	GGCAAGUCCAACUCAAGGU	ACCUUGAGUUGGACUUGCC		[608-626]
					412	CUGGUUGCCUUGGUAGGAU	AUCCUACCAAGGCAACCAG		[428-446]
413	GGUCAAUCUUGCAACAACC	GGUUGUUGCAAGAUUGACC		[752-770]
					414	GAUACAUGGUUGUGACCUG	CAGGUCACAACCAUGUAUC		[1380-1398]
415	UGGGAUUCUUUCCAUUAUG	CAUAAUGGAAAGAAUCCCA		[1015-1033]

416	UAAGAGAAGCACUUUGGGA	UCCCAAAGUGCUUCUCUUA		[1001-1019]
					417	AGGGAGAAGCAUGAAAAAG	CUUUUUCAUGCUUCUCCCU		[1241-1259]
418	UUGAAAAGGACACCUUUUA	UAAAAGGUGUCCUUUUCAA		[1312-1330]
					419	UAAAAAUCAUUGAUUGUCA	UGACAAUCAAUGAUUUUUA		[1742-1760]
420	AAUAUGGGUUGCAUUUGGU	ACCAAAUGCAACCCAUAUU		[1681-1699]
					421	ACUUUGGGAUUCUUUCCAU	AUGGAAAGAAUCCCAAAGU		[1011-1029]
422	GGGAAGAUGAUGAGCUACU	AGUAGCUCAUCAUCUUCCC		[836-854]
					423	GAAGAAGUAAAACCGUUUG	CAAACGGUUUUACUUCUUC		[111-129]
424	GCUCUCUCUGGUCAAUUUU	AAAAUUGACCAGAGAGAGC		[946-964]
					425	UUCAGCUCUUCCACCUACA	UGUAGGUGGAAGAGCUGAA		[462-480]
426	UUUCCCUUAGCUAUGGAAA	UUUCCAUAGCUAAGGGAAA		[7-25]
					427	AGAGAAGCACUUUGGGAUU	AAUCCCAAAGUGCUUCUCU		[1003-1021]
428	GCAUAAUAAGCUAAAGAGG	CCUCUUUAGCUUAUUAUGC		[1435-1453]
					429	ACAAAUGGAGGAAUAUGAC	GUCAUAUUCCUCCAUUUGU		[1188-1206]
430	CUGAGAAGAAGUAAAACCG	CGGUUUUACUUCUUCUCAG		[107-125]
					431	UGUGACCUGAGGAUUUAAG	CUUAAAUCCUCAGGUCACA		[1390-1408]
432	GCUCUAAGAGAAGCACUUU	AAAGUGCUUCUCUUAGAGC		[997-1015]
					433	CCUAUGGAAUUGUCCUGCU	AGCAGGACAAUUCCAUAGG		[651-669]
434	AAGGACACCUUUUAACUCA	UGAGUUAAAAGGUGUCCUU		[1317-1335]
					435	UCCUGCUUUCUGGAGUGAA	UUCACUCCAGAAAGCAGGA		[663-681]
436	UCUGUAGCUCCUCAACUCA	UGAGUUGAGGAGCUACAGA		[1150-1168]
					437	UUGAUUGUCAGCUACUAAU	AUUAGUAGCUGACAAUCAA		[1751-1769]
438	UUAGCUAUGGAAACUCUAU	AUAGAGUUUCCAUAGCUAA		[13-31]
					439	AAGAGAAGCACUUUGGGAU	AUCCCAAAGUGCUUCUCUU		[1002-1020]
440	UCAUGGUUCUGGUUGCCUU	AAGGCAACCAGAACCAUGA		[420-438]
					441	UGUUCUACACUCAUCUUAG	CUAAGAUGAGUGUAGAACA		[1271-1289]
442	GAUUUAAGGGAUGGAAAAG	CUUUUCCAUCCCUUAAAUC		[1401-1419]

443	AAUGAAACUGGGCUGUACU	AGUACAGCCCAGUUUCAUU		[707-725]
					444	AGGUCCAUGCCUCUGGAAU	AUUCCAGAGGCAUGGACCU		[623-641]
445	ACAGAUAAGCAAGAGAGAU	AUCUCUCUUGCUUAUCUGU		[1526-1544]
					446	CUGUCUUUCAGAUACAUGG	CCAUGUAUCUGAAAGACAG		[1370-1388]
447	AAGAGAGGGAACCACAGCA	UGCUGUGGUUCCCUCUCUU		[374-392]
					448	UCUUCUUACAUGCAUUUGA	UCAAAUGCAUGUAAGAAGA		[1076-1094]
449	UGGGUUGCAUUUGGUCAAG	CUUGACCAAAUGCAACCCA		[1685-1703]
					450	AGAAGUAAAACCGUUUGCU	AGCAAACGGUUUUACUUCU		[113-131]
451	CAGUGUUCAAUCUUACCAG	CUGGUAAGAUUGAACACUG		[897-915]
					452	ACUCAUUUCAUUCCUAACA	UGUUAGGAAUGAAAUGAGU		[1554-1572]
453	GCCCAUUUAACAGGCAAGU	ACUUGCCUGUUAAAUGGGC		[596-614]
					454	GUAGCUCCUCAACUCACCU	AGGUGAGUUGAGGAGCUAC		[1153-1171]
455	AGUAAGAAGACAUGAACCA	UGGUUCAUGUCUUCUUACU		[1100-1118]
					456	AGCCUCUACAGGACUGAGA	UCUCAGUCCUGUAGAGGCU		[94-112]
457	UUGAGGUCAAGUAAGAAGA	UCUUCUUACUUGACCUCAA		[1091-1109]
					458	UUGUGAUGUUUUUCAUGGU	ACCAUGAAAAACAUCACAA		[408-426]
459	UAUGGGUUGCAUUUGGUCA	UGACCAAAUGCAACCCAUA		[1683-1701]
					460	CAAGUAAGAAGACAUGAAC	GUUCAUGUCUUCUUACUUG		[1098-1116]
461	CUACAGGACUGAGAAGAAG	CUUCUUCUCAGUCCUGUAG		[99-117]
					462	GAAUGGGAAGACACCUAUG	CAUAGGUGUCUUCCCAUUC		[638-656]
463	UAAAGAGAGAAUGUAGAUA	UAUCUACAUUCUCUCUUUA		[1641-1659]
					464	GGUCUUCUUACAUGCAUUU	AAAUGCAUGUAAGAAGACC		[1074-1092]
465	UGUUGUAUUCAGUGAGGGU	ACCCUCACUGAAUACAACA		[1058-1076]
					466	CAUCUUAGUGCCUGAGAGU	ACUCUCAGGCACUAAGAUG		[1282-1300]
467	UUUUGUGAAAUGAAAACAU	AUGUUUUCAUUUCACAAAA		[1813-1831]
					468	GCAUGAAAAAGCAGCUACC	GGUAGCUGCUUUUUCAUGC		[1249-1267]
469	AUCUUUGGAGAAGCAAAUA	UAUUUGCUUCUCCAAAGAU		[532-550]

470	CAUGGUUCUGGUUGCCUUG	CAAGGCAACCAGAACCAUG		[421-439]
					471	AAGCAAGAGAGAUGUUUUG	CAAAACAUCUCUCUUGCUU		[1532-1550]
472	ACAUGGUUGUGACCUGAGG	CCUCAGGUCACAACCAUGU		[1383-1401]
					473	CUCAUUUCAUUCCUAACAC	GUGUUAGGAAUGAAAUGAG		[1555-1573]
474	UUGAAUGCUUCCUGACAAU	AUUGUCAGGAAGCAUUCAA		[1707-1725]
					475	UCCUCAACUCACCUAAUGU	ACAUUAGGUGAGUUGAGGA		[1158-1176]
476	CUUGACACCUCAGCCUCUA	UAGAGGCUGAGGUGUCAAG		[83-101]
					477	AUUAUGAUUCUUUGUUACA	UGUAACAAAGAAUCAUAAU		[1028-1046]
478	CUAAGAGAAGCACUUUGGG	CCCAAAGUGCUUCUCUUAG		[1000-1018]
					479	UUCAGUGAGGGUCUUCUUA	UAAGAAGACCCUCACUGAA		[1065-1083]
480	UAAAAAGUAUAUGUUAGGA	UCCUAACAUAUACUUUUUA		[1836-1854]
					481	AUAUUGUGAAGUACAUAUU	AAUAUGUACUUCACAAUAU		[1657-1675]
482	UGUGCAUUUUUGUGAAAUG	CAUUUCACAAAAAUGCACA		[1806-1824]
					483	AAGUACAUAUUAGGAAAAU	AUUUUCCUAAUAUGUACUU		[1665-1683]
484	ACACCUAUGGAAUUGUCCU	AGGACAAUUCCAUAGGUGU		[648-666]
					485	CUUAGUGCCUGAGAGUAUU	AAUACUCUCAGGCACUAAG		[1285-1303]
486	GCAAGAGAGAUGUUUUGGG	CCCAAAACAUCUCUCUUGC		[1534-1552]
					487	GAGAAGCAUGAAAAAGCAG	CUGCUUUUUCAUGCUUCUC		[1244-1262]
488	GCAUCUUCACUUCUAAAUG	CAUUUAGAAGUGAAGAUGC		[1481-1499]
					489	CCUCUACAGGACUGAGAAG	CUUCUCAGUCCUGUAGAGG		[96-114]
490	GGAAAAGGAAGACUAGAGG	CCUCUAGUCUUCCUUUUCC		[1413-1431]
					491	UCAAUUUUGAGGAAUCUCA	UGAGAUUCCUCAAAAUUGA		[957-975]
492	UGGAAAAGGAAGACUAGAG	CUCUAGUCUUCCUUUUCCA		[1412-1430]
					493	CCUGAGGAUUUAAGGGAUG	CAUCCCUUAAAUCCUCAGG		[1395-1413]
494	AAAAGGAGCUGAGGAAAGU	ACUUUCCUCAGCUCCUUUU		[576-594]
					495	UGUCUUUCAGAUACAUGGU	ACCAUGUAUCUGAAAGACA		[1371-1389]
496	AGCUACUAAUGAUGUUUUC	GAAAACAUCAUUAGUAGCU		[1760-1778]

497	CUAUAAGAGAGAUCCAGCU	AGCUGGAUCUCUCUUAUAG		[28-46]
					498	UUCUAAAUGCAUAUCCUGA	UCAGGAUAUGCAUUUAGAA		[1491-1509]
499	GCAGUGUUCAAUCUUACCA	UGGUAAGAUUGAACACUGC		[896-914]
					500	UGGUUGCCUUGGUAGGAUU	AAUCCUACCAAGGCAACCA		[429-447]

表B 18HTRA2-HtrA丝氨酸肽酶2

表B 19KEAP1-kelch-类ECH-相关的蛋白1

表B 20LGALS3-凝集素，半乳糖苷-结合，可溶，3

表B 21LRDD-富含亮氨酸的重复序列，含死亡域

表B 22NOS1-一氧化氮合酶1

No.	正义链siRNA	反义链siRNA	其他Sp	人-10835172：686-4990
					1	CCAAGAAGAUGAACUUAGA	UCUAAGUUCAUCUUCUUGG		[2532-2550]
2	GGAGGGACAUUAAGAAAUA	UAUUUCUUAAUGUCCCUCC		[104-122]
					3	CGGUGUAAUUCCUCCCUAA	UUAGGGAGGAAUUACACCG		[6376-6394]
4	GCGGCAAUUUGAUAUCCAA	UUGGAUAUCAAAUUGCCGC		[4486-4504]
					5	CCACAGAUAUAAAGAACAA	UUGUUCUUUAUAUCUGUGG		[6895-6913]

6	AGAUGAUGUCAACAUUGAA	UUCAAUGUUGACAUCAUCU		[3535-3553]
					7	GAGGGACAUUAAGAAAUAA	UUAUUUCUUAAUGUCCCUC		[105-123]
8	CAUUGAAGAGAGCAAAAAA	UUUUUUGCUCUCUUCAAUG	Ms	[4945-4963]
					9	CGAACCUAAAGAAUAUGAA	UUCAUAUUCUUUAGGUUCG		[6016-6034]
10	GGGAGAGGAUCCUGAAGAU	AUCUUCAGGAUCCUCUCCC		[3423-3441]
					11	GAACGUACGAAGUGACCAA	UUGGUCACUUCGUACGUUC		[4899-4917]
12	GGAGACUGUUAAAGUGAAA	UUUCACUUUAACAGUCUCC		[6737-6755]
					13	GGGACAUUAAGAAAUAAAU	AUUUAUUUCUUAAUGUCCC		[107-125]
14	GAAUAUGAAUGGAUUAAAU	AUUUAAUCCAUUCAUAUUC		[6026-6044]
					15	CGAUGCAAUGCUUUUCUAA	UUAGAAAAGCAUUGCAUCG		[5186-5204]
16	AGAGGAGUGGGAAAUUGAU	AUCAAUUUCCCACUCCUCU		[5675-5693]
					17	GGCUGUGCUUUGAUGGAAA	UUUCCAUCAAAGCACAGCC		[3164-3182]
18	GGGCUGUCUCCCAAUGAAA	UUUCAUUGGGAGACAGCCC		[5699-5717]
					19	CCGGCUGCAAGUUUUGUAA	UUACAAAACUUGCAGCCGG		[5009-5027]
20	CGCGAAGAAAGCAACCAGA	UCUGGUUGCUUUCUUCGCG		[1246-1264]
					21	GAUAAAGGAGGGACAUUAA	UUAAUGUCCCUCCUUUAUC		[98-116]
22	GGCUCAUGAUGCCUCAGAU	AUCUGAGGCAUCAUGAGCC		[265-283]
					23	GAAUGGAUUAAAUGUUAAA	UUUAACAUUUAAUCCAUUC		[6032-6050]
24	GGCUGGAAGAGGUGAACAA	UUGUUCACCUCUUCCAGCC		[1839-1857]
					25	GAAACAAUAUCAAGUAACA	UGUUACUUGAUAUUGUUUC		[6064-6082]
26	GAGAGGAGUGGGAAAUUGA	UCAAUUUCCCACUCCUCUC		[5674-5692]
					27	GGAGUGGGAAAUUGAUUAA	UUAAUCAAUUUCCCACUCC		[5678-5696]
28	CAAUGAAGAUACCCAGAGA	UCUCUGGGUAUCUUCAUUG		[307-325]
					29	CCCAGAAAGAGACAAGAAA	UUUCUUGUCUCUUUCUGGG		[6490-6508]
30	CAAAGAGUUUAUUGAUCAA	UUGAUCAAUAAACUCUUUG		[1774-1792]
					31	CACGCUUCCUCAAGGUCAA	UUGACCUUGAGGAAGCGUG		[1593-1611]
32	CGAGAUGGAGAAGGACCAA	UUGGUCCUUCUCCAUCUCG		[4298-4316]

33	GGUUGGACGUCACUGCUAA	UUAGCAGUGACGUCCAACC		[60-78]
					34	UGAUGUCCAUGGAAGAAUA	UAUUCUUCCAUGGACAUCA		[3054-3072]
35	AGGUGAUGUCCAUGGAAGA	UCUUCCAUGGACAUCACCU		[3051-3069]
					36	CCAGAUGGUGAAAGUGGAA	UUCCACUUUCACCAUCUGG		[3874-3892]
37	GUGUCUUGCUAUACAGAAA	UUUCUGUAUAGCAAGACAC		[6583-6601]
					38	CCAUGAGGAUAUUUUUGGA	UCCAAAAAUAUCCUCAUGG		[4870-4888]
39	CGGGAUGCACUGAGUACAU	AUGUACUCAGUGCAUCCCG		[1671-1689]
					40	GGAUGACAACCGAUACCAU	AUGGUAUCGGUUGUCAUCC		[4855-4873]
41	AAGGGAAGCCCAUUCUAAA	UUUAGAAUGGGCUUCCCUU		[6950-6968]
					42	CAGGCAAAUCGCAAGCUUA	UAAGCUUGCGAUUUGCCUG		[2988-3006]
43	CAAGGUGAUGUCCAUGGAA	UUCCAUGGACAUCACCUUG		[3049-3067]
					44	UAUCCAAUGUCCACAAAAA	UUUUUGUGGACAUUGGAUA		[3651-3669]
45	GAUCGCAGCUGGAAGAGAA	UUCUCUUCCAGCUGCGAUC		[3581-3599]
					46	GCUGGAAGAGGUGAACAAA	UUUGUUCACCUCUUCCAGC		[1840-1858]
47	CCCUCAACUCAGAUCAAAA	UUUUGAUCUGAGUUGAGGG		[6324-6342]
					48	AGGAGACUGUUAAAGUGAA	UUCACUUUAACAGUCUCCU		[6736-6754]
49	GGACAUUAAGAAAUAAAUU	AAUUUAUUUCUUAAUGUCC		[108-126]
					50	CAUGUUCGGUGUUCAGCAA	UUGCUGAACACCGAACAUG		[697-715]
51	GAUCAAUACUAUUCAUCAA	UUGAUGAAUAGUAUUGAUC		[1787-1805]
					52	CGCCCAUGUACCUGAAACA	UGUUUCAGGUACAUGGGCG		[5607-5625]
53	CCAUCUUCCAGGCCUUCAA	UUGAAGGCCUGGAAGAUGG	大鼠，Ms	[3966-3984]
					54	CACUCUUCCACAGAUAUAA	UUAUAUCUGUGGAAGAGUG		[6888-6906]
55	AGAGAAUAGUUCACAUCUA	UAGAUGUGAACUAUUCUCU		[321-339]
					56	CCAUGUACCUGAAACAUUU	AAAUGUUUCAGGUACAUGG		[5610-5628]
57	GGAGUACGAGGAAUGGAAA	UUUCCAUUCCUCGUACUCC		[4099-4117]
					58	CAUAAUUGUUCUAGUUAGA	UCUAACUAGAACAAUUAUG		[5637-5655]
59	GCUACAAGGUCCGAUUCAA	UUGAAUCGGACCUUGUAGC	大鼠，Ms	[3219-3237]

60	CAGACAAACCAAAGAAGUA	UACUUCUUUGGUUUGUCUG		[4647-4665]
					61	GGGAGAUGAUGUCAACAUU	AAUGUUGACAUCAUCUCCC		[3532-3550]
62	AAAGGAGGGACAUUAAGAA	UUCUUAAUGUCCCUCCUUU		[101-119]
					63	GGCUGCUGAUGUCCUCAAA	UUUGAGGACAUCAGCAGCC		[4762-4780]
64	CAGAUAUAAAGAACAAACA	UGUUUGUUCUUUAUAUCUG		[6898-6916]
					65	UGUGCACCUGGAACAUGAA	UUCAUGUUCCAGGUGCACA		[3079-3097]
66	CACAGAUAUAAAGAACAAA	UUUGUUCUUUAUAUCUGUG		[6896-6914]
					67	CCCAGAGAAUAGUUCACAU	AUGUGAACUAUUCUCUGGG		[318-336]
68	GAGUGGGAAAUUGAUUAAA	UUUAAUCAAUUUCCCACUC		[5679-5697]
					69	CUACCAGCGAGAAGGAGAA	UUCUCCUUCUCGCUGGUAG		[4047-4065]
70	GAGAAUAGUUCACAUCUAU	AUAGAUGUGAACUAUUCUC		[322-340]
					71	CCUGGAGACCACCUUUACA	UGUAAAGGUGGUCUCCAGG		[1003-1021]
72	GGGAAGGGAUCCCUUUGUA	UACAAAGGGAUCCCUUCCC		[6434-6452]
					73	CUGACACCCUCCACCUUAA	UUAAGGUGGAGGGUGUCAG		[1638-1656]
74	GAGGCAACCUGUUGAAUUU	AAAUUCAACAGGUUGCCUC		[6395-6413]
					75	GAAGGGAAGCCCAUUCUAA	UUAGAAUGGGCUUCCCUUC		[6949-6967]
76	GGCGGAUGCAGGAAAUCAU	AUGAUUUCCUGCAUCCGCC		[470-488]
					77	CCAGAAAGAGACAAGAAAU	AUUUCUUGUCUCUUUCUGG		[6491-6509]
78	UGGAAACAAUAUCAAGUAA	UUACUUGAUAUUGUUUCCA		[6062-6080]
					79	GGAUGAGGUUGGAAAGAGU	ACUCUUUCCAACCUCAUCC		[6165-6183]
80	ACGGGAUGUUCAACUACAU	AUGUAGUUGAACAUCCCGU		[2007-2025]
					81	CUCCAAAGCCCACAUGGAA	UUCCAUGUGGGCUUUGGAG		[1819-1837]
82	GAUGAUGUCAACAUUGAAA	UUUCAAUGUUGACAUCAUC		[3536-3554]
					83	CCUUAAGAGCACAUUGGAA	UUCCAAUGUGCUCUUAAGG		[1651-1669]
84	GAACACGCAUGUCUGGAAA	UUUCCAGACAUGCGUGUUC		[2833-2851]
					85	GGAACACGCAUGUCUGGAA	UUCCAGACAUGCGUGUUCC		[2832-2850]
86	CUCUGCAGUUGAUCUCCAA	UUGGAGAUCAACUGCAGAG		[6266-6284]

87	CCGAGUCCUUCAUUAAGCA	UGCUUAAUGAAGGACUCGG		[2664-2682]
					88	CCUCAACUCAGAUCAAAAA	UUUUUGAUCUGAGUUGAGG		[6325-6343]
89	CUUCCACAGAUAUAAAGAA	UUCUUUAUAUCUGUGGAAG		[6892-6910]
					90	AGGCAAAUCGCAAGCUUAU	AUAAGCUUGCGAUUUGCCU		[2989-3007]
91	GCCUGGGAUUUCUGGUGAA	UUCACCAGAAAUCCCAGGC		[765-783]
					92	ACUCUUCCACAGAUAUAAA	UUUAUAUCUGUGGAAGAGU		[6889-6907]
93	GCUCACUCUUCCACAGAUA	UAUCUGUGGAAGAGUGAGC		[6885-6903]
					94	GCAGCUGGAAGAGAAACAA	UUGUUUCUCUUCCAGCUGC		[3585-3603]
95	GCGAUGCAAUGCUUUUCUA	UAGAAAAGCAUUGCAUCGC		[5185-5203]
					96	UGAAGACGUCCGCACAAAA	UUUUGUGCGGACGUCUUCA		[1735-1753]
97	UGACAUUGUGCACCUGGAA	UUCCAGGUGCACAAUGUCA		[3073-3091]
					98	ACGCUGAGCUGACGUCAAA	UUUGACGUCAGCUCAGCGU		[521-539]
99	CGGUGUUCAGCAAAUCCAG	CUGGAUUUGCUGAACACCG		[703-721]
					100	CACUCGAGAUGGAGAAGGA	UCCUUCUCCAUCUCGAGUG		[4294-4312]
10	AAGCUUUGGUGCCUGGAAA	UUUCCAGGCACCAAAGCUU		[6049-6067]
					102	AGGGACAUUAAGAAAUAAA	UUUAUUUCUUAAUGUCCCU		[106-124]
103	CGGCUGUGCUUUGAUGGAA	UUCCAUCAAAGCACAGCCG		[3163-3181]
					104	CAAUGUCCACAAAAAGCGA	UCGCUUUUUGUGGACAUUG		[3655-3673]
105	GGGUCUUCAGAGAGCUGUA	UACAGCUCUCUGAAGACCC		[4608-4626]
					106	GAACCUAAAGAAUAUGAAU	AUUCAUAUUCUUUAGGUUC		[6017-6035]
107	CCAUCACUUCCUUAGAGAA	UUCUCUAAGGAAGUGAUGG		[441-459]
					108	CAGGCAGUUCCCAGAAAGA	UCUUUCUGGGAACUGCCUG		[6481-6499]
109	GGAAGCUAGUUACCAUGGA	UCCAUGGUAACUAGCUUCC		[672-690]
					110	CCAACAUGCUCCUAGAGAU	AUCUCUAGGAGCAUGUUGG		[2403-2421]
111	CGCUGGUGGAGAUCAAUAU	AUAUUGAUCUCCACCAGCG		[2586-2604]
					112	CUUCAAGAAGCUAGCAGAA	UUCUGCUAGCUUCUUGAAG		[2890-2908]
113	GCAAGGGUUUGCAGGAGUA	UACUCCUGCAAACCCUUGC		[4086-4104]

114	CAGAGAUAUGCAUACAGCA	UGCUGUAUGCAUAUCUCUG		[2205-2223]
					115	AGGCAGAGAUGAAAGAUAU	AUAUCUUUCAUCUCUGCCU		[1374-1392]
116	AGAAUUUGCUGCAUUUAGA	UCUAAAUGCAGCAAAUUCU		[5729-5747]
					117	CCAACUCUGUGCAGGAAGA	UCUUCCUGCACAGAGUUGG		[3192-3210]
118	UGGAAGAGGUGAACAAAGA	UCUUUGUUCACCUCUUCCA		[1842-1860]
					119	CCACCGAGUCCUUCAUUAA	UUAAUGAAGGACUCGGUGG		[2661-2679]
120	CUGUCAACCAGAUGGUGAA	UUCACCAUCUGGUUGACAG		[3867-3885]
					121	CCAAGGCAGAGAUGAAAGA	UCUUUCAUCUCUGCCUUGG		[1371-1389]
122	GUCUUGCUAUACAGAAAAA	UUUUUCUGUAUAGCAAGAC		[6585-6603]
					123	CUUUAGGUGUCAUCAGUAA	UUACUGAUGACACCUAAAG		[3915-3933]
124	CACGGGAUGUUCAACUACA	UGUAGUUGAACAUCCCGUG		[2006-2024]
					125	CCAAGUUUGAGUGGUUCAA	UUGAACCACUCAAACUUGG		[2346-2364]
126	CCCUUUGUAUACUUUUUUA	UAAAAAAGUAUACAAAGGG		[6444-6462]
					127	GGGCAUAUCUUGUUGUUCA	UGAACAACAAGAUAUGCCC		[6630-6648]
128	GCAACAGCGGCAAUUUGAU	AUCAAAUUGCCGCUGUUGC		[4480-4498]
					129	GCAUGAAACCACUGGAACA	UGUUCCAGUGGUUUCAUGC		[5271-5289]
130	CCACAAAAAGCGAGUCUCA	UGAGACUCGCUUUUUGUGG		[3661-3679]
					131	AGAUCUGAUCCGCAUCUAA	UUAGAUGCGGAUCAGAUCU		[280-298]
132	CCAAGGUGAUGUCCAUGGA	UCCAUGGACAUCACCUUGG		[3048-3066]
					133	AAGUUUUAAACCUGUUAAA	UUUAACAGGUUUAAAACUU		[6284-6302]
134	GCCGGCAAUCCAAGAUAGA	UCUAUCUUGGAUUGCCGGC		[4548-4566]
					135	GGAAGCUGGUUAAAGUGGA	UCCACUUUAACCAGCUUCC		[6149-6167]
136	GUGACAUGAACCCAUCCAA	UUGGAUGGGUUCAUGUCAC		[5776-5794]
					137	CCAUUAAAGACAAAUUGAU	AUCAAUUUGUCUUUAAUGG		[7095-7113]
138	CUCGGAAGCUAGUUACCAU	AUGGUAACUAGCUUCCGAG		[669-687]
					139	GAGAUGAUGUCAACAUUGA	UCAAUGUUGACAUCAUCUC		[3534-3552]
140	GAAGCUGGUUAAAGUGGAU	AUCCACUUUAACCAGCUUC		[6150-6168]

141	GCUGCAUUUAGAUUUUGAU	AUCAAAAUCUAAAUGCAGC		[5736-5754]
					142	GUACCUGAAACAUUUGGAA	UUCCAAAUGUUUCAGGUAC		[5614-5632]
143	CUCUGACUCCCAAAAAUCA	UGAUUUUUGGGAGUCAGAG		[3253-3271]
					144	AGACAUGUACCCUGAUGAA	UUCAUCAGGGUACAUGUCU		[4243-4261]
145	CUGGAAACAAUAUCAAGUA	UACUUGAUAUUGUUUCCAG		[6061-6079]
					146	CAUCCUUCUCAGCAUGCAA	UUGCAUGCUGAGAAGGAUG		[1709-1727]
147	GGCAGUUCCCAGAAAGAGA	UCUCUUUCUGGGAACUGCC		[6483-6501]
					148	CAAUACUAUUCAUCAAUUA	UAAUUGAUGAAUAGUAUUG		[1790-1808]
149	GUCAUACGAACCUAAAGAA	UUCUUUAGGUUCGUAUGAC		[6010-6028]
					150	CCUUCAUUGAAGAGAGCAA	UUGCUCUCUUCAAUGAAGG	Ms	[4941-4959]
151	UGAAUGGAUUAAAUGUUAA	UUAACAUUUAAUCCAUUCA		[6031-6049]
					152	UGAAGGAGCGGGUCAGUAA	UUACUGACCCGCUCCUUCA		[780-798]
153	GAAUCCAGGUGGACAGAGA	UCUCUGUCCACCUGGAUUC	大鼠，Ms	[1395-1413]
					154	GGUGAUGUCCAUGGAAGAA	UUCUUCCAUGGACAUCACC		[3052-3070]
155	CGAAGAAAGCAACCAGAGU	ACUCUGGUUGCUUUCUUCG		[1248-1266]
					156	AAGGAGGGACAUUAAGAAA	UUUCUUAAUGUCCCUCCUU		[102-120]
157	ACCAGAUGGUGAAAGUGGA	UCCACUUUCACCAUCUGGU		[3873-3891]
					158	GAGGAGUGGGAAAUUGAUU	AAUCAAUUUCCCACUCCUC		[5676-5694]
159	CCGAGUCUUCAAUGACCUA	UAGGUCAUUGAAGACUCGG		[1462-1480]
					160	GUCCAUUGCCUUCAUUGAA	UUCAAUGAAGGCAAUGGAC		[4933-4951]
161	GGUCCAAGCUGCAGGUAUU	AAUACCUGCAGCUUGGACC		[1962-1980]
					162	UGGGAUUUCUGGUGAAGGA	UCCUUCACCAGAAAUCCCA		[768-786]
163	UAAGAGGCAACCUGUUGAA	UUCAACAGGUUGCCUCUUA		[6392-6410]
					164	GCGCUGGUGGAGAUCAAUA	UAUUGAUCUCCACCAGCGC		[2585-2603]
165	CUCCUUUCCUGCAAACCCA	UGGGUUUGCAGGAAAGGAG		[6969-6987]
					166	GGUGUCUGCUAAAGAGGAA	UUCCUCUUUAGCAGACACC		[6654-6672]
167	CCUGUUAAAUUAAUUUUGA	UCAAAAUUAAUUUAACAGG		[6294-6312]

168	GCCGGCUGCAAGUUUUGUA	UACAAAACUUGCAGCCGGC		[5008-5026]
					169	AGAGGAUCCUGAAGAUGAG	CUCAUCUUCAGGAUCCUCU		[3426-3444]
170	AGGAGUACGAGGAAUGGAA	UUCCAUUCCUCGUACUCCU		[4098-4116]
					171	CAAUAUCAAGUAACAAUAU	AUAUUGUUACUUGAUAUUG		[6068-6086]
172	CUAGUAGCUUUCCUCCCAA	UUGGGAGGAAAGCUACUAG		[6998-7016]
					173	GGCAACAGCGGCAAUUUGA	UCAAAUUGCCGCUGUUGCC		[4479-4497]
174	AAGAGUUUAUUGAUCAAUA	UAUUGAUCAAUAAACUCUU		[1776-1794]
					175	UGAUCUCCAAAGUUUUAAA	UUUAAAACUUUGGAGAUCA		[6275-6293]
176	AGAACGACCGAGUCUUCAA	UUGAAGACUCGGUCGUUCU		[1455-1473]
					177	AUACGAACCUAAAGAAUAU	AUAUUCUUUAGGUUCGUAU		[6013-6031]
178	CAUACGAACCUAAAGAAUA	UAUUCUUUAGGUUCGUAUG		[6012-6030]
					179	AGAAUAUGAAUGGAUUAAA	UUUAAUCCAUUCAUAUUCU		[6025-6043]
180	CAGUUUGGGUGUCUGCUAA	UUAGCAGACACCCAAACUG		[6647-6665]
					181	CUUCAAACACGCCUUUGAU	AUCAAAGGCGUGUUUGAAG		[3028-3046]
182	UGUCCAACAUGCUCCUAGA	UCUAGGAGCAUGUUGGACA		[2400-2418]
					183	CAUACAGCAGGGCUGGAAA	UUUCCAGCCCUGCUGUAUG		[2215-2233]
184	UGAGGUUUUCAGCUCCUAA	UUAGGAGCUGAAAACCUCA	大鼠，Ms	[4972-4990]
					185	CCUAAAUCCAGUCGGUCAA	UUGACCGACUGGAUUUAGG		[3716-3734]
186	CCCAUUAAAGACAAAUUGA	UCAAUUUGUCUUUAAUGGG		[7094-7112]
					187	CUGCAUUUAGAUUUUGAUA	UAUCAAAAUCUAAAUGCAG		[5737-5755]
188	CAGGAAGAGGCUUUCAGGA	UCCUGAAAGCCUCUUCCUG	Ms	[3467-3485]
					189	AAACAAUAUCAAGUAACAA	UUGUUACUUGAUAUUGUUU		[6065-6083]
190	UGCCUGUCGUCCUCAACAA	UUGUUGAGGACGACAGGCA		[1497-1515]
					191	CUGCGAACGUACGAAGUGA	UCACUUCGUACGUUCGCAG		[4895-4913]
192	CGAAGCUCCAGAACUCACA	UGUGAGUUCUGGAGCUUCG		[3625-3643]
					193	AAGUGAAAAGGCAAUCUAU	AUAGAUUGCCUUUUCACUU		[6748-6766]
194	AGAACAAUGAACUGCUCAA	UUGAGCAGUUCAUUGUUCU		[1287-1305]

195	CCAAGAUAGAUCAUAUCUA	AGAUAUGAUCUAUCUUGG	大鼠，Ms	[4557-4575]
					196	GAAUGUUCUGCUGGUUCUA	AGAACCAGCAGAACAUUC		[6553-6571]
197	AGGUGAACAAAGAGAUCGA	CGAUCUCUUUGUUCACCU		[1848-1866]
					198	AGGAGUGGGAAAUUGAUUA	AAUCAAUUUCCCACUCCU		[5677-5695]
199	CCCUAAGAGGCAACCUGUU	ACAGGUUGCCUCUUAGGG		[6389-6407]
					200	CGGCUCAGUCCCUACAUAU	UAUGUAGGGACUGAGCCG		[153-171]
201	ACAUCAUUCUUGCGGUCAA	UGACCGCAAGAAUGAUGU		[870-888]
					202	GGCAAUGAAGAUACCCAGA	CUGGGUAUCUUCAUUGCC		[305-323]
203	CCUUUGUAUACUUUUUUAA	UAAAAAAGUAUACAAAGG		[6445-6463]
					204	CAGAGACAGGCAAAUCGCA	GCGAUUUGCCUGUCUCUG		[2982-3000]
205	AUCGCAGCUGGAAGAGAAA	UUCUCUUCCAGCUGCGAU		[3582-3600]
					206	GCUUCAAGAAGCUAGCAGA	CUGCUAGCUUCUUGAAGC		[2889-2907]
207	CAAGUAACAAUAUGAUUAU	UAAUCAUAUUGUUACUUG		[6074-6092]
					208	CUGUGCAGGAAGAAAGGAA	UCCUUUCUUCCUGCACAG		[3198-3216]
209	CCAUUGCCUUCAUUGAAGA	CUUCAAUGAAGGCAAUGG		[4935-4953]
					210	AGAGAUGAAAGAUAUGGGA	CCCAUAUCUUUCAUCUCU		[1378-1396]
211	CAACCAUCACUUCCUUAGA	CUAAGGAAGUGAUGGUUG		[438-456]
					212	CUGUUAAAGUGAAAAGGCA	GCCUUUUCACUUUAACAG		[6742-6760]
213	GGAUAAAGGAGGGACAUUA	AAUGUCCCUCCUUUAUCC		[97-115]
					214	GAGCAAAAAAGACACCGAU	UCGGUGUCUUUUUUGCUC		[4954-4972]
215	CUAUCCAAUGUCCACAAAA	UUUGUGGACAUUGGAUAG		[3650-3668]
					216	GGAAGAAUAUGACAUUGUG	ACAAUGUCAUAUUCUUCC		[3064-3082]
217	GAAGAAAGGAAGAGCUACA	GUAGCUCUUCCUUUCUUC		[3206-3224]
					218	CUAGCACUUACCAGCUCAA	UGAGCUGGUAAGUGCUAG		[1872-1890]
219	AGUCAUAAUGUCAUACGAA	UCGUAUGACAUUAUGACU		[6001-6019]
					220	GCUGGAAGAGAAACAAGUU	ACUUGUUUCUCUUCCAGC		[3588-3606]
221	GGUGCAUGAAACCACUGGA	UCCAGUGGUUUCAUGCACC		[5268-5286]

222	AAUGUCAUACGAACCUAAA	UUUAGGUUCGUAUGACAUU		[6007-6025]
					223	CAUCCAAUGGAUUGUGCAA	UUGCACAAUCCAUUGGAUG		[5788-5806]
224	UGGAAGUUAUGUUGUUCAA	UUGAACAACAUAACUUCCA		[5903-5921]
					225	CAACUUUGAGAGUGCUGGA	UCCAGCACUCUCAAAGUUG		[3298-3316]
226	GAGAAGGACCAAUUCACCA	UGGUGAAUUGGUCCUUCUC		[4305-4323]
					227	GUGAAAAGGCAAUCUAUGA	UCAUAGAUUGCCUUUUCAC		[6750-6768]
228	GUUUAUUGAUCAAUACUAU	AUAGUAUUGAUCAAUAAAC		[1780-1798]
					229	UGAAGAUACCCAGAGAAUA	UAUUCUCUGGGUAUCUUCA		[310-328]
230	UGCCUGGAAACAAUAUCAA	UUGAUAUUGUUUCCAGGCA		[6058-6076]
					231	GACAACUCCCGCUACAAUA	UAUUGUAGCGGGAGUUGUC		[2498-2516]
232	GAUGCAAUGCUUUUCUAAU	AUUAGAAAAGCAUUGCAUC		[5187-5205]
					233	CCCAAGGAUGGAAAGGGAA	UUCCCUUUCCAUCCUUGGG		[6537-6555]
234	UGGAGGAGUUCCCAUCUAU	AUAGAUGGGAACUCCUCCA		[4149-4167]
					235	GCCUGGAAACAAUAUCAAG	CUUGAUAUUGUUUCCAGGC		[6059-6077]
236	GUGCAUGAAACCACUGGAA	UUCCAGUGGUUUCAUGCAC		[5269-5287]
					237	GGAAGAGGUGAACAAAGAG	CUCUUUGUUCACCUCUUCC		[1843-1861]
238	CGUCCUCAACAACCCAUAU	AUAUGGGUUGUUGAGGACG		[1504-1522]
					239	CACGCCCAUGUACCUGAAA	UUUCAGGUACAUGGGCGUG		[5605-5623]
240	GAAUAGUUCACAUCUAUCA	UGAUAGAUGUGAACUAUUC		[324-342]
					241	GAUGAGGGAUGACAACCGA	UCGGUUGUCAUCCCUCAUC		[4849-4867]
242	CCGGCAAUCCAAGAUAGAU	AUCUAUCUUGGAUUGCCGG		[4549-4567]
					243	GCUUCCUCAAGGUCAAGAA	UUCUUGACCUUGAGGAAGC		[1596-1614]
244	GAAGGGAUCCCUUUGUAUA	UAUACAAAGGGAUCCCUUC		[6436-6454]
					245	CAACAGCGGCAAUUUGAUA	UAUCAAAUUGCCGCUGUUG		[4481-4499]
246	GGAAUUGGAGCCGGUGUAA	UUACACCGGCUCCAAUUCC		[6365-6383]
					247	CAUGGAAGAAUAUGACAUU	AAUGUCAUAUUCUUCCAUG		[3061-3079]
248	GGCUCCUUAGCCGUCAAAA	UUUUGACGGCUAAGGAGCC		[3687-3705]

249	UAGCUUCCAGAGUGACAAA	UUUGUCACUCUGGAAGCUA		[2617-2635]
					250	GUGUGGGAGAUGAUGUCAA	UUGACAUCAUCUCCCACAC		[3528-3546]
251	GAGCACAUUGGAAACGGGA	UCCCGUUUCCAAUGUGCUC		[1657-1675]
					252	CCAAAGGCUUUCUUUCCAA	UUGGAAAGAAAGCCUUUGG		[7013-7031]
253	GAGAUGAAAGAUAUGGGAA	UUCCCAUAUCUUUCAUCUC		[1379-1397]
					254	CAUGAUGCCUCAGAUCUGA	UCAGAUCUGAGGCAUCAUG		[269-287]
255	UGAACUUAGACAUGAGGAA	UUCCUCAUGUCUAAGUUCA		[2541-2559]
					256	GAAUUUGCUGCAUUUAGAU	AUCUAAAUGCAGCAAAUUC		[5730-5748]
257	AAACCACAUUUCUUUUAUA	UAUAAAAGAAAUGUGGUUU		[6601-6619]
					258	CUGGAGGAGUUCCCAUCUA	UAGAUGGGAACUCCUCCAG		[4148-4166]
259	GAACGACCGAGUCUUCAAU	AUUGAAGACUCGGUCGUUC		[1456-1474]
					260	ACGACUUCCGAGUCUGGAA	UUCCAGACUCGGAAGUCGU		[2109-2127]
261	CAGUUUGCCUCCCUAGCUA	UAGCUAGGGAGGCAAACUG		[4031-4049]
					262	UGGUGGACCUGAGCUAUGA	UCAUAGCUCAGGUCCACCA		[900-918]
263	CAGUUUUUCCUAGUCAUAA	UUAUGACUAGGAAAAACUG		[5990-6008]
					264	GUUGGACGUCACUGCUAAU	AUUAGCAGUGACGUCCAAC		[61-79]
265	GGGAGAGGAGUGGGAAAUU	AAUUUCCCACUCCUCUCCC		[5672-5690]
					266	AGAAGUACGUGCAGGACAU	AUGUCCUGCACGUACUUCU		[4659-4677]
267	CUAUCAUGCGUCACUUCUA	UAGAAGUGACGCAUGAUAG		[337-355]
					268	UCACUUCCUUAGAGAAUAA	UUAUUCUCUAAGGAAGUGA		[444-462]
269	CUCCAGCAAUAGCAUCCAA	UUGGAUGCUAUUGCUGGAG		[5878-5896]
					270	GGGAAGAACUUGUCCCUCA	UGAGGGACAAGUUCUUCCC		[6236-6254]
271	CCCACGGGAUGUUCAACUA	UAGUUGAACAUCCCGUGGG		[2004-2022]
					272	AAUGAAGAUACCCAGAGAA	UUCUCUGGGUAUCUUCAUU		[308-326]
273	GGCAAUCCAAGAUAGAUCA	UGAUCUAUCUUGGAUUGCC		[4551-4569]
					274	CUAAGAGGCAACCUGUUGA	UCAACAGGUUGCCUCUUAG		[6391-6409]
275	UGUUCAACUACAUCUGUAA	UUACAGAUGUAGUUGAACA	大鼠，Ms	[2013-2031]

276	ACAAUAUCAAGUAACAAUA	UAUUGUUACUUGAUAUUGU		[6067-6085]
					277	GGGUGUCUGCUAAAGAGGA	UCCUCUUUAGCAGACACCC		[6653-6671]
278	GAAGAGGUGAACAAAGAGA	UCUCUUUGUUCACCUCUUC		[1844-1862]
					279	AAAGAAUAUGAAUGGAUUA	UAAUCCAUUCAUAUUCUUU		[6023-6041]
280	UAGUAGCUUUCCUCCCAAA	UUUGGGAGGAAAGCUACUA		[6999-7017]
					281	CUCCUACUCUGACUCCCAA	UUGGGAGUCAGAGUAGGAG		[3247-3265]
282	CUGAAGACGUCCGCACAAA	UUUGUGCGGACGUCUUCAG		[1734-1752]
					283	AAGGCAGAGAUGAAAGAUA	UAUCUUUCAUCUCUGCCUU		[1373-1391]
284	CGCCUUAGAUCUGAGUCCA	UGGACUCAGAUCUAAGGCG	大鼠，Ms	[4919-4937]
					285	GUGCAGGAAGAAAGGAAGA	UCUUCCUUUCUUCCUGCAC		[3200-3218]
286	GGAAGGGAUCCCUUUGUAU	AUACAAAGGGAUCCCUUCC		[6435-6453]
					287	GCUGUGCUUUGAUGGAAAU	AUUUCCAUCAAAGCACAGC		[3165-3183]
288	GCUACAAUAUCCUGGAGGA	UCCUCCAGGAUAUUGUAGC		[2508-2526]
					289	CAAGCUGCAGGUAUUCGAU	AUCGAAUACCUGCAGCUUG		[1966-1984]
290	AGCCCUCAUGUGACAUGAA	UUCAUGUCACAUGAGGGCU		[5767-5785]
					291	AGACGUCCGCACAAAAGGA	UCCUUUUGUGCGGACGUCU		[1738-1756]
292	CAACCGAUACCAUGAGGAU	AUCCUCAUGGUAUCGGUUG		[4861-4879]
					293	GUGCACCUGGAACAUGAAA	UUUCAUGUUCCAGGUGCAC		[3080-3098]
294	CCUUUUUUAUGAUGACAUU	AAUGUCAUCAUAAAAAAGG		[5398-5416]
					295	GAGAGGAUCCUGAAGAUGA	UCAUCUUCAGGAUCCUCUC		[3425-3443]
296	UAAUGUCAUACGAACCUAA	UUAGGUUCGUAUGACAUUA		[6006-6024]
					297	AGUGACCAACCGCCUUAGA	UCUAAGGCGGUUGGUCACU	大鼠，Ms	[4909-4927]
298	AGUUUUUCCUAGUCAUAAU	AUUAUGACUAGGAAAAACU		[5991-6009]
					299	GAAAGAUAUGGGAAUCCAG	CUGGAUUCCCAUAUCUUUC		[1384-1402]
300	CAAAGAAGUACGUGCAGGA	UCCUGCACGUACUUCUUUG		[4656-4674]
					301	CAACUCUGUGCAGGAAGAA	UUCUUCCUGCACAGAGUUG		[3193-3211]
302	AGAUGAAAGAUAUGGGAAU	AUUCCCAUAUCUUUCAUCU		[1380-1398]

303	CCAAGUCUUCGGUAGGAAU	AUUCCUACCGAAGACUUGG		[6351-6369]
					304	CUUUGGUGCCUGGAAACAA	UUGUUUCCAGGCACCAAAG		[6052-6070]
305	GGCUCAGUCCCUACAUAUU	AAUAUGUAGGGACUGAGCC		[154-172]
					306	CUGUAACCAUGUCAAGUAU	AUACUUGACAUGGUUACAG	大鼠	[2026-2044]
307	GGUACAUGGGCACAGAGAU	AUCUCUGUGCCCAUGUACC	大鼠	[2460-2478]
					308	GCAUUGUGAGGUCUUCAGA	UCUGAAGACCUCACAAUGC		[642-660]
309	CUCAGUCCCUACAUAUUUA	UAAAUAUGUAGGGACUGAG		[156-174]
					310	ACGGCUCAGUCCCUACAUA	UAUGUAGGGACUGAGCCGU		[152-170]
311	UGUCUUGCUAUACAGAAAA	UUUUCUGUAUAGCAAGACA		[6584-6602]
					312	GUGCUUUGAUGGAAAUGAG	CUCAUUUCCAUCAAAGCAC		[3168-3186]
313	CCUCCUCCAGCAAUAGCAU	AUGCUAUUGCUGGAGGAGG		[5874-5892]
					314	CCUUCAUUAAGCACAUGGA	UCCAUGUGCUUAAUGAAGG		[2670-2688]
315	CGAGCAUACCCUCACUUUU	AAAAGUGAGGGUAUGCUCG		[3359-3377]
					316	CUGAGUCCAUUGCCUUCAU	AUGAAGGCAAUGGACUCAG		[4929-4947]
317	CGCAGCUGGAAGAGAAACA	UGUUUCUCUUCCAGCUGCG		[3584-3602]
					318	CGAACGUACGAAGUGACCA	UGGUCACUUCGUACGUUCG		[4898-4916]
319	GGCUUUAGGUGUCAUCAGU	ACUGAUGACACCUAAAGCC		[3913-3931]
					320	ACAAAUAAGUUACCCUCAA	UUGAGGGUAACUUAUUUGU		[6312-6330]
321	CAUGCAUCCUUCUCAGCAU	AUGCUGAGAAGGAUGCAUG		[1705-1723]
					322	CCUAAAGAAUAUGAAUGGA	UCCAUUCAUAUUCUUUAGG		[6020-6038]
323	UAGUCAUAAUGUCAUACGA	UCGUAUGACAUUAUGACUA		[6000-6018]
					324	GCUUUAGGUGUCAUCAGUA	UACUGAUGACACCUAAAGC		[3914-3932]
325	GUGCCUGGAAACAAUAUCA	UGAUAUUGUUUCCAGGCAC		[6057-6075]
					326	GACAGACACUGCUGAACCU	AGGUUCAGCAGUGUCUGUC		[5033-5051]
327	UGUCCAUGGAAGAAUAUGA	UCAUAUUCUUCCAUGGACA		[3057-3075]
					328	AGUCCAUUGCCUUCAUUGA	UCAAUGAAGGCAAUGGACU		[4932-4950]
329	AGCCCAUUCUAAACUCCUU	AAGGAGUUUAGAAUGGGCU		[6956-6974]

330	UGGUGAAAGUGGAACUGCU	AGCAGUUCCACUUUCACCA		[3879-3897]
					331	GUGACAAAGUGACCAUUGU	ACAAUGGUCACUUUGUCAC		[2628-2646]
332	AAAGCUUUGGUGCCUGGAA	UUCCAGGCACCAAAGCUUU		[6048-6066]
					333	ACGGGUGCAUGAAACCACU	AGUGGUUUCAUGCACCCGU		[5265-5283]
334	AGGAGUUCCCAUCUAUCCA	UGGAUAGAUGGGAACUCCU		[4152-4170]
					335	UGUUGAAUUUACUCUCUCA	UGAGAGAGUAAAUUCAACA		[6404-6422]
336	CGGCUUUAGGUGUCAUCAG	CUGAUGACACCUAAAGCCG		[3912-3930]
					337	GAUGUCCAUGGAAGAAUAU	AUAUUCUUCCAUGGACAUC		[3055-3073]
338	GUGACAACUCCCGCUACAA	UUGUAGCGGGAGUUGUCAC		[2496-2514]
					339	GAAACGGGAUGCACUGAGU	ACUCAGUGCAUCCCGUUUC		[1667-1685]
340	GAGACUGUUAAAGUGAAAA	UUUUCACUUUAACAGUCUC		[6738-6756]
					341	AGGGUUUGCAGGAGUACGA	UCGUACUCCUGCAAACCCU		[4089-4107]
342	UGUUAAAGUGAAAAGGCAA	UUGCCUUUUCACUUUAACA		[6743-6761]
					343	UGACCAUUGUUGACCAUCA	UGAUGGUCAACAAUGGUCA		[2637-2655]
344	AAGUUAUGUUGUUCAAAGA	UCUUUGAACAACAUAACUU		[5906-5924]
					345	AAUAAUGGAAGCUGGUUAA	UUAACCAGCUUCCAUUAUU		[6143-6161]
346	GACCAUUGUUGACCAUCAC	GUGAUGGUCAACAAUGGUC		[2638-2656]
					347	GUGUAAUUCCUCCCUAAGA	UCUUAGGGAGGAAUUACAC		[6378-6396]
348	CAAAGAGAUCGACACCACU	AGUGGUGUCGAUCUCUUUG		[1855-1873]
					349	AGCACAUGGAGAAUGAGUA	UACUCAUUCUCCAUGUGCU		[2679-2697]
350	GAAGAGAGCAAAAAAGACA	UGUCUUUUUUGCUCUCUUC	Ms	[4949-4967]
					351	UACUCUGACUCCCAAAAAU	AUUUUUGGGAGUCAGAGUA		[3251-3269]
352	CACCCAUACCAGCUAGAAU	AUUCUAGCUGGUAUGGGUG		[5823-5841]
					353	AUGACAUUGUGCACCUGGA	UCCAGGUGCACAAUGUCAU		[3072-3090]
354	ACCAGGAGAUGCUCAACUA	UAGUUGAGCAUCUCCUGGU	大鼠，Ms	[2775-2793]
					355	GCAACCUGUUGAAUUUACU	AGUAAAUUCAACAGGUUGC		[6398-6416]
356	AGAUCAUAUCUACAGGGAA	UUCCCUGUAGAUAUGAUCU		[4564-4582]

357	GCACCUGGAACAUGAAACU	AGUUUCAUGUUCCAGGUGC		[3082-3100]
					358	GCUGUCUCCCAAUGAAAGA	UCUUUCAUUGGGAGACAGC		[5701-5719]
359	GGAAGUUAUGUUGUUCAAA	UUUGAACAACAUAACUUCC		[5904-5922]
					360	UUUGGUGCCUGGAAACAAU	AUUGUUUCCAGGCACCAAA		[6053-6071]
361	ACCAAUUCACCACGGCGUA	UACGCCGUGGUGAAUUGGU		[4312-4330]
					362	GAGUUCCCAUCUAUCCAGA	UCUGGAUAGAUGGGAACUC		[4154-4172]
363	GAAAGAGGCAUUCCCAGAA	UUCUGGGAAUGCCUCUUUC		[5714-5732]
					364	AAUCCAAGAUAGAUCAUAU	AUAUGAUCUAUCUUGGAUU	大鼠，Ms	[4554-4572]
365	AGCUGACGUCAAAGACAGA	UCUGUCUUUGACGUCAGCU		[527-545]
					366	GCAAAAAAGACACCGAUGA	UCAUCGGUGUCUUUUUUGC		[4956-4974]
367	GGUUAAAGUGGAUGAGGUU	AACCUCAUCCACUUUAACC		[6156-6174]
					368	CCAUAAUUGUUCUAGUUAG	CUAACUAGAACAAUUAUGG		[5636-5654]
369	GUGACCAACCGCCUUAGAU	AUCUAAGGCGGUUGGUCAC	大鼠，Ms	[4910-4928]
					370	ACAUGGAAAGGCUGGAAGA	UCUUCCAGCCUUUCCAUGU		[1830-1848]
371	GUGGGAAAUUGAUUAAAGG	CCUUUAAUCAAUUUCCCAC		[5681-5699]
					372	AGUGGGAAAUUGAUUAAAG	CUUUAAUCAAUUUCCCACU		[5680-5698]
373	ACAAUUCCCUCAUCAGCAA	UUGCUGAUGAGGGAAUUGU		[3561-3579]
					374	ACAGAGAUUUGGACGGCAA	UUGCCGUCCAAAUCUCUGU		[1407-1425]
375	CCACUGCUUUCAUUGAAGA	UCUUCAAUGAAAGCAGUGG		[5522-5540]
					376	AGGUGGACAGAGAUUUGGA	UCCAAAUCUCUGUCCACCU		[1401-1419]
377	CCGAUACCAUGAGGAUAUU	AAUAUCCUCAUGGUAUCGG		[4864-4882]
					378	CCUGGAAACAAUAUCAAGU	ACUUGAUAUUGUUUCCAGG		[6060-6078]
379	AGGAAGAAAGGAAGAGCUA	UAGCUCUUCCUUUCUUCCU		[3204-3222]
					380	GGAAGAACUUGUCCCUCAG	CUGAGGGACAAGUUCUUCC		[6237-6255]
381	CAGUGAUGAUAGGAUAAAG	CUUUAUCCUAUCAUCACUG		[86-104]
					382	AAGUGGAACUGCUGGAGGA	UCCUCCAGCAGUUCCACUU		[3885-3903]
383	UGACAUGAACCCAUCCAAU	AUUGGAUGGGUUCAUGUCA		[5777-5795]

384	CCUGAUGAAGUGCACCUCA	UGAGGUGCACUUCAUCAGG		[4253-4271]
					385	UAAUUGUUCUAGUUAGAAA	UUUCUAACUAGAACAAUUA		[5639-5657]
386	CUUCAUUGAAGAGAGCAAA	UUUGCUCUCUUCAAUGAAG	Ms	[4942-4960]
					387	AAAGAGACAAGAAAUCCUA	UAGGAUUUCUUGUCUCUUU		[6495-6513]
388	AUGAAUGGAUUAAAUGUUA	UAACAUUUAAUCCAUUCAU		[6030-6048]
					389	GCACAAAAGGACAGCUCUU	AAGAGCUGUCCUUUUGUGC		[1746-1764]
390	GAAGUGACCAACCGCCUUA	UAAGGCGGUUGGUCACUUC	大鼠，Ms	[4907-4925]
					391	AAUCCUUUAUAGCUUUGGA	UCCAAAGCUAUAAAGGAUU		[7030-7048]
392	CUUCUAAUCCUGAAGGGAA	UUCCCUUCAGGAUUAGAAG		[6938-6956]
					393	CCCAGAAUUUGCUGCAUUU	AAAUGCAGCAAAUUCUGGG		[5726-5744]
394	CCCAGGGAAGGAAACUGUU	AACAGUUUCCUUCCCUGGG		[7065-7083]
					395	GUUGAUCUCCAAAGUUUUA	UAAAACUUUGGAGAUCAAC		[6273-6291]
396	UCCCAGAAAGAGACAAGAA	UUCUUGUCUCUUUCUGGGA		[6489-6507]
					397	CUACUCUGACUCCCAAAAA	UUUUUGGGAGUCAGAGUAG		[3250-3268]
398	CCUCAACAACCCAUAUUCA	UGAAUAUGGGUUGUUGAGG		[1507-1525]
					399	CAAUGUCAUUUCUGUUCGU	ACGAACAGAAAUGACAUUG		[724-742]
400	GGAGGAGUUCCCAUCUAUC	GAUAGAUGGGAACUCCUCC		[4150-4168]
					401	AGUCCUUCAUUAAGCACAU	AUGUGCUUAAUGAAGGACU		[2667-2685]
402	GCCUUAGAUCUGAGUCCAU	AUGGACUCAGAUCUAAGGC	大鼠，Ms	[4920-4938]
					403	GGCAUAUCUUGUUGUUCAG	CUGAACAACAAGAUAUGCC		[6631-6649]
404	CAAAGUUUUAAACCUGUUA	UAACAGGUUUAAAACUUUG		[6282-6300]
					405	CUGCCUUCCUUUAAUCCCA	UGGGAUUAAAGGAAGGCAG		[6857-6875]
406	CGACCUCAGAGACAACUUU	AAAGUUGUCUCUGAGGUCG	大鼠	[3286-3304]
					407	CUGAGGUGGUUCUCACUGA	UCAGUGAGAACCACCUCAG		[1623-1641]
408	CCCGCUACAAUAUCCUGGA	UCCAGGAUAUUGUAGCGGG		[2505-2523]
					409	GGCAAUUUGAUAUCCAACA	UGUUGGAUAUCAAAUUGCC		[4488-4506]
410	CCCACCUCAGGAAAACAGU	ACUGUUUUCCUGAGGUGGG		[1541-1559]

411	CCAAGCUGCAGGUAUUCGA	UCGAAUACCUGCAGCUUGG		[1965-1983]
					412	UGCUCACUCUUCCACAGAU	AUCUGUGGAAGAGUGAGCA		[6884-6902]
413	CCUGGAACAUGAAACUCUG	CAGAGUUUCAUGUUCCAGG		[3085-3103]
					414	UCCAAAGCCCACAUGGAAA	UUUCCAUGUGGGCUUUGGA		[1820-1838]
415	GCCCAAUGUCAUUUCUGUU	AACAGAAAUGACAUUGGGC		[721-739]
					416	ACAUGUUCGGUGUUCAGCA	UGCUGAACACCGAACAUGU		[696-714]
417	GCUAAUUCGUUUCAGUGAU	AUCACUGAAACGAAUUAGC		[74-92]
					418	CAGACACUGCUGAACCUUU	AAAGGUUCAGCAGUGUCUG		[5035-5053]
419	UGAGGGAUGACAACCGAUA	UAUCGGUUGUCAUCCCUCA		[4851-4869]
					420	AAGUUACCCUCAACUCAGA	UCUGAGUUGAGGGUAACUU		[6318-6336]
421	UCAUUAAGCACAUGGAGAA	UUCUCCAUGUGCUUAAUGA		[2673-2691]
					422	ACAAUGAACUGCUCAAGGA	UCCUUGAGCAGUUCAUUGU		[1290-1308]
423	GAAGAUACCCAGAGAAUAG	CUAUUCUCUGGGUAUCUUC		[311-329]
					424	AGAUGAACUUAGACAUGAG	CUCAUGUCUAAGUUCAUCU		[2538-2556]
425	CUGGGUGAGGAGCUACUUA	UAAGUAGCUCCUCACCCAG		[192-210]
					426	CGCACAAAAGGACAGCUCU	AGAGCUGUCCUUUUGUGCG		[1745-1763]
427	CCACCCAUACCAGCUAGAA	UUCUAGCUGGUAUGGGUGG		[5822-5840]
					428	AACUCUGUGCAGGAAGAAA	UUUCUUCCUGCACAGAGUU		[3194-3212]
429	ACAUCUGUAACCAUGUCAA	UUGACAUGGUUACAGAUGU	大鼠	[2022-2040]
					430	UCACUCUUCCACAGAUAUA	UAUAUCUGUGGAAGAGUGA		[6887-6905]
431	ACGCAUGUCUGGAAAGGCA	UGCCUUUCCAGACAUGCGU		[2837-2855]
					432	AGAGACAGGCAAAUCGCAA	UUGCGAUUUGCCUGUCUCU		[2983-3001]
433	AGUUUGGGUGUCUGCUAAA	UUUAGCAGACACCCAAACU		[6648-6666]
					434	UGUGCAGUUCACAGAGAUA	UAUCUCUGUGAACUGCACA		[2194-2212]
435	CAAUAUCGCGGUUCUCUAU	AUAGAGAACCGCGAUAUUG		[2599-2617]
					436	GGAUCCUGAAGAUGAGGGA	UCCCUCAUCUUCAGGAUCC		[3429-3447]
437	CUACAAUAUCCUGGAGGAA	UUCCUCCAGGAUAUUGUAG		[2509-2527]

438	AGAUUUGGACGGCAAGUCA	UGACUUGCCGUCCAAAUCU		[1411-1429]
					439	CGGCUUCAAGAAGCUAGCA	UGCUAGCUUCUUGAAGCCG		[2887-2905]
440	GCCUGGAAGUUAUGUUGUU	AACAACAUAACUUCCAGGC		[5900-5918]
					441	AAACCUCCAGAGCCCUAAA	UUUAGGGCUCUGGAGGUUU		[3703-3721]
442	CCAGAAUUUGCUGCAUUUA	UAAAUGCAGCAAAUUCUGG		[5727-5745]
					443	UGCCUUCCUUUAAUCCCAA	UUGGGAUUAAAGGAAGGCA		[6858-6876]
444	CCUAGUAGCUUUCCUCCCA	UGGGAGGAAAGCUACUAGG		[6997-7015]
					445	CCAUCGGCUUCAAGAAGCU	AGCUUCUUGAAGCCGAUGG		[2883-2901]
446	UGCUGCAUUUAGAUUUUGA	UCAAAAUCUAAAUGCAGCA		[5735-5753]
					447	GGCUGUCUCCCAAUGAAAG	CUUUCAUUGGGAGACAGCC		[5700-5718]
448	AAAUCCAGUCGGUCAACUA	UAGUUGACCGACUGGAUUU		[3719-3737]
					449	AACUCACGGGUGCAUGAAA	UUUCAUGCACCCGUGAGUU		[5260-5278]
450	CAGGAGACUGUUAAAGUGA	UCACUUUAACAGUCUCCUG		[6735-6753]
					451	CGCUACUAUUCCAUCAGCU	AGCUGAUGGAAUAGUAGCG	Ms	[4217-4235]
452	UCAAGAACUGGGAGACUGA	UCAGUCUCCCAGUUCUUGA		[1608-1626]
					453	UGUCAUACGAACCUAAAGA	UCUUUAGGUUCGUAUGACA		[6009-6027]
454	GGCAGAGAUGAAAGAUAUG	CAUAUCUUUCAUCUCUGCC		[1375-1393]
					455	GGAUUAAAUGUUAAAGCUU	AAGCUUUAACAUUUAAUCC		[6036-6054]
456	CUCAGUUUUUCCUAGUCAU	AUGACUAGGAAAAACUGAG		[5988-6006]
					457	CCGGUGUAAUUCCUCCCUA	UAGGGAGGAAUUACACCGG		[6375-6393]
458	AGAUGGAGAAGGACCAAUU	AAUUGGUCCUUCUCCAUCU		[4300-4318]
					459	AGCCCAAUGUCAUUUCUGU	ACAGAAAUGACAUUGGGCU		[720-738]
460	GCUGAGCUGACGUCAAAGA	UCUUUGACGUCAGCUCAGC		[523-541]
					461	CAAUAAGGAUCUUCCCACU	AGUGGGAAGAUCCUUAUUG		[5935-5953]
462	AGUUGAUCUCCAAAGUUUU	AAAACUUUGGAGAUCAACU		[6272-6290]
					463	CCUUCAAGUACUACCUGGA	UCCAGGUAGUACUUGAAGG	大鼠，Ms	[3978-3996]
464	AGUUAUGUUGUUCAAAGAA	UUCUUUGAACAACAUAACU		[5907-5925]

465	UCCUAGUCAUAAUGUCAUA	UAUGACAUUAUGACUAGGA		[5997-6015]
					466	UAGCUACCAGCGAGAAGGA	UCCUUCUCGCUGGUAGCUA		[4044-4062]
467	AGCUAGUUACCAUGGAGGA	UCCUCCAUGGUAACUAGCU		[675-693]
					468	CCUCAGAUCUGAUCCGCAU	AUGCGGAUCAGAUCUGAGG		[276-294]
469	GCACUUACCAGCUCAAGGA	UCCUUGAGCUGGUAAGUGC		[1875-1893]
					470	GUGAUGAUAGGAUAAAGGA	UCCUUUAUCCUAUCAUCAC		[88-106]
471	UCGAGAUGGAGAAGGACCA	UGGUCCUUCUCCAUCUCGA		[4297-4315]
					472	AGGCAACCUGUUGAAUUUA	UAAAUUCAACAGGUUGCCU		[6396-6414]
473	AUGAUGUCAACAUUGAAAA	UUUUCAAUGUUGACAUCAU		[3537-3555]
					474	CUUAAGAGCACAUUGGAAA	UUUCCAAUGUGCUCUUAAG		[1652-1670]
475	AGAAGAUGAACUUAGACAU	AUGUCUAAGUUCAUCUUCU		[2535-2553]
					476	CUUUGAUGGAAAUGAGGCA	UGCCUCAUUUCCAUCAAAG		[3171-3189]
477	GUGGGCAUAUCUUGUUGUU	AACAACAAGAUAUGCCCAC		[6628-6646]
					478	UAAACUCCUUUCCUGCAAA	UUUGCAGGAAAGGAGUUUA		[6965-6983]
479	CCACAUGGAAAGGCUGGAA	UUCCAGCCUUUCCAUGUGG		[1828-1846]
					480	GGAAUGUUCUGCUGGUUCU	AGAACCAGCAGAACAUUCC		[6552-6570]
481	CCAUGGAAGAAUAUGACAU	AUGUCAUAUUCUUCCAUGG		[3060-3078]
					482	UCGUGAAUGCCCUGAUCGA	UCGAUCAGGGCAUUCACGA		[3828-3846]
483	CAUUGUGCACCUGGAACAU	AUGUUCCAGGUGCACAAUG		[3076-3094]
					484	GGUCAACCAUCACUUCCUU	AAGGAAGUGAUGGUUGACC		[435-453]
485	CCAAAGAGUUUAUUGAUCA	UGAUCAAUAAACUCUUUGG		[1773-1791]
					486	CGACCGAGUCUUCAAUGAC	GUCAUUGAAGACUCGGUCG		[1459-1477]
487	AAGUGACCAUUGUUGACCA	UGGUCAACAAUGGUCACUU		[2634-2652]
					488	CAAGAAGGUCUUCAAGGCA	UGCCUUGAAGACCUUCUUG		[3493-3511]
489	ACCUUAAGAGCACAUUGGA	UCCAAUGUGCUCUUAAGGU		[1650-1668]
					490	AAAGGCUGGAAGAGGUGAA	UUCACCUCUUCCAGCCUUU		[1836-1854]
491	GAUUAAAUGUUAAAGCUUU	AAAGCUUUAACAUUUAAUC		[6037-6055]

492	GUCUAUCCAAUGUCCACAA	UUGUGGACAUUGGAUAGAC		[3648-3666]
					493	GAUGGAAAGGGAAUGUUCU	AGAACAUUCCCUUUCCAUC		[6543-6561]
494	UUGUGCACCUGGAACAUGA	UCAUGUUCCAGGUGCACAA		[3078-3096]
					495	GGAGAAGGACCAAUUCACC	GGUGAAUUGGUCCUUCUCC		[4304-4322]
496	AAGUGGAUGAGGUUGGAAA	UUUCCAACCUCAUCCACUU		[6161-6179]
					497	UAUAAAGAACAAACACUUA	UAAGUGUUUGUUCUUUAUA		[6902-6920]
498	CUCACUCUUCCACAGAUAU	AUAUCUGUGGAAGAGUGAG		[6886-6904]
					499	GCGUAUUCAUCAGCCGGAU	AUCCGGCUGAUGAAUACGC		[4833-4851]
500	GGACGUCACUGCUAAUUCG	CGAAUUAGCAGUGACGUCC		[64-82]

表B 23NOS2A-一氧化氮合酶2A

No.	正义链siRNA	反义链siRNA	其他Sp	人-24041028：265-3726
					1	CGGCAUGUGAGGAUCAAAA	UUUUGAUCCUCACAUGCCG		511-529]
2	CCUCAUUCCUGCUUUAAAA	UUUUAAAGCAGGAAUGAGG		51-69]
					3	GGGUGGAAGCGGUAACAAA	UUUGUUACCGCUUCCACCC		758-776]
4	CGGUAACAAAGGAGAUAGA	UCUAUCUCCUUUGUUACCG		767-785]
					5	CGCUCUUCAUGCUGAAAGA	UCUUUCAGCAUGAAGAGCG		2087-2105]
6	CUUCAAAGAGGCAAAAAUA	UAUUUUUGCCUCUUUGAAG	大鼠	723-741]
					7	GAAGAGAGAUUCCAUUGAA	UUCAAUGGAAUCUCUCUUC		1793-1811]
8	GUAACAAAGGAGAUAGAAA	UUUCUAUCUCCUUUGUUAC		769-787]
					9	GAAAGAGCUCAACAACAAA	UUUGUUGUUGAGCUCUUUC		2100-2118]
10	GGCAUGUGAGGAUCAAAAA	UUUUUGAUCCUCACAUGCC		512-530]
					11	GGGAAAGAAGUCUCCAGAA	UUCUGGAGACUUCUUUCCC		453-471]
12	AAGAGAGAUUCCAUUGAAA	UUUCAAUGGAAUCUCUCUU		1794-1812]
					13	CCACCAGUAUGCAAUGAAU	AUUCAUUGCAUACUGGUGG		303-321]
14	GGUCCAUUAUGACUCCCAA	UUGGGAGUCAUAAUGGACC		614-632]
					15	GGGAAAAAGACAUCAACAA	UUGUUGAUGUCUUUUUCCC		323-341]
16	CCUUCAAAGAGGCAAAAAU	AUUUUUGCCUCUUUGAAGG	大鼠	722-740]

17	GAGAUAGAAACAACAGGAA	UUCCUGUUGUUUCUAUCUC		[778-796]
					18	GCCUCAUUCCUGCUUUAAA	UUUAAAGCAGGAAUGAGGC		[50-68]
19	GCCUUUGGACCUCAGCAAA	UUUGCUGAGGUCCAAAGGC		[2412-2430]
					20	AGAUGAGCUUCUACCUCAA	UUGAGGUAGAAGCUCAUCU		[672-690]
21	CUUUGUAGCGAGUCGAAAA	UUUUCGACUCGCUACAAAG		[5-23]
					22	CAACAACAAUGUGGAGAAA	UUUCUCCACAUUGUUGUUG		[336-354]
23	GUGCGUUACUCCACCAACA	UGUUGGUGGAGUAACGCAC		[955-973]
					24	CGCCUUUGCUCAUGACAUU	AAUGUCAUGAGCAAAGGCG		[2169-2187]
25	CAUUGAAAGUCUUGGUCAA	UUGACCAAGACUUUCAAUG		[1805-1823]
					26	GGAGAUAGAAACAACAGGA	UCCUGUUGUUUCUAUCUCC		[777-795]
27	CCUGUAUGCUGAUGCGCAA	UUGCGCAUCAGCAUACAGG		[1838-1856]
					28	CUUGGAGACAAAAUCUUAA	UUAAGAUUUUGUCUCCAAG		[3954-3972]
29	CAGGUAGAGGCCUGGAAAA	UUUUCCAGGCCUCUACCUG		[1738-1756]
					30	GCUCCUUCAAAGAGGCAAA	UUUGCCUCUUUGAAGGAGC	大鼠	[719-737]
31	CCAGAAGCGCUAUCACGAA	UUCGUGAUAGCGCUUCUGG		[3621-3639]
					32	GCGGGAUGACUUUCCAAGA	UCUUGGAAAGUCAUCCCGC		[539-557]
33	GGUAACAAAGGAGAUAGAA	UUCUAUCUCCUUUGUUACC		[768-786]
					34	CUCUGUAUUUAAAAAACUA	UAGUUUUUUAAAUACAGAG		[4096-4114]
35	CUUGGAAAUUUCUGUUCAA	UUGAACAGAAAUUUCCAAG		[275-293]
					36	CAGAGUACAGCAAGUGGAA	UUCCACUUGCUGUACUCUG		[2861-2879]
37	GCAAUGGAGAGAAACUGAA	UUCAGUUUCUCUCCAUUGC		[2063-2081]
					38	GAAGAACAUCUGAGCUCAA	UUGAGCUCAGAUGUUCUUC		[201-219]
39	CAGAAUCCUUCAUGAAGUA	UACUUCAUGAAGGAUUCUG		[1583-1601]
					40	AGACCAAAUUCCACCAGUA	UACUGGUGGAAUUUGGUCU		[293-311]
41	AAAGGAGAUAGAAACAACA	UGUUGUUUCUAUCUCCUUU		[774-792]
					42	GGAGAGAAACUGAAGAAAU	AUUUCUUCAGUUUCUCUCC		[2068-2086]
43	CGGGAAAGAAGUCUCCAGA	UCUGGAGACUUCUUUCCCG		[452-470]

44	CACGGCAUGUGAGGAUCAA	UUGAUCCUCACAUGCCGUG		[509-527]
					45	CAGCGGGAUGACUUUCCAA	UUGGAAAGUCAUCCCGCUG		[537-555]
46	CCUUGGAGACAAAAUCUUA	UAAGAUUUUGUCUCCAAGG		[3953-3971]
					47	CCAGAUAAGUGACAUAAGU	ACUUAUGUCACUUAUCUGG		[222-240]
48	GCUGAGUGCACCACUUCAA	UUGAAGUGGUGCACUCAGC		[4012-4030]
					49	GCUGCAGAAUCCUUCAUGA	UCAUGAAGGAUUCUGCAGC		[1579-1597]
50	GGCAAUGGAGAGAAACUGA	UCAGUUUCUCUCCAUUGCC		[2062-2080]
					51	GACCCUGAGCUCUUCGAAA	UUUCGAAGAGCUCAGGGUC		[1207-1225]
52	CAGCCUCAUUCCUGCUUUA	UAAAGCAGGAAUGAGGCUG		[48-66]
					53	CCAAGAACGUGUUCACCAU	AUGGUGAACACGUUCUUGG	大鼠	[2450-2468]
54	AAGCGGAGACCCAAGAGAA	UUCUCUUGGGUCUCCGCUU		[1777-1795]
					55	GUUUGAUGUCCGAGGCAAA	UUUGCCUCGGACAUCAAAC		[2313-2331]
56	CAAUAUUACGGCUCCUUCA	UGAAGGAGCCGUAAUAUUG		[709-727]
					57	GGAGAUGGAGGAAAGUGAU	AUCACUUUCCUCCAUCUCC		[3810-3828]
58	CACAGAAGAGCCUGAGAGA	UCUCUCAGGCUCUUCUGUG		[2814-2832]
					59	UGCGUUACUCCACCAACAA	UUGUUGGUGGAGUAACGCA		[956-974]
60	CAAGCUAUCGAAUUUGUCA	UGACAAAUUCGAUAGCUUG		[688-706]
					61	UGAAAGAGCUCAACAACAA	UUGUUGUUGAGCUCUUUCA		[2099-2117]
62	UGUUCAAGACCAAAUUCCA	UGGAAUUUGGUCUUGAACA		[287-305]
					63	ACGGCAUGUGAGGAUCAAA	UUUGAUCCUCACAUGCCGU		[510-528]
64	AAAAAGACAUCAACAACAA	UUGUUGUUGAUGUCUUUUU		[326-344]
					65	AGCCUUUGGACCUCAGCAA	UUGCUGAGGUCCAAAGGCU		[2411-2429]
66	GAGGCAAACAGCACAUUCA	UGAAUGUGCUGUUUGCCUC		[2324-2342]
					67	GCAAGUGGAAGUUCACCAA	UUGGUGAACUUCCACUUGC		[2870-2888]
68	UGCUGAAAGAGCUCAACAA	UUGUUGAGCUCUUUCAGCA		[2096-2114]
					69	AAUCGCUCUUCAUGCUGAA	UUCAGCAUGAAGAGCGAUU		[2084-2102]
70	CUUUGCUCAUGACAUUGAU	AUCAAUGUCAUGAGCAAAG		[2172-2190]

71	GUAGCGAGUCGAAAACUGA	UCAGUUUUCGACUCGCUAC		[9-27]
					72	GGGAGAUGGAGGAAAGUGA	UCACUUUCCUCCAUCUCCC		[3809-3827]
73	CAGAGACAGGAAAAUCAGA	UCUGAUUUUCCUGUCUCUG		[1898-1916]
					74	AAGUGACCUGCUUUGUAAA	UUUACAAAGCAGGUCACUU		[237-255]
75	GGCAAACAGCACAUUCAGA	UCUGAAUGUGCUGUUUGCC		[2326-2344]
					76	CGAAUUUGUCAACCAAUAU	AUAUUGGUUGACAAAUUCG		[696-714]
77	ACAGGAACCUACCAACUGA	UCAGUUGGUAGGUUCCUGU		[790-808]
					78	CUGCCGGCACAGAACUUAA	UUAAGUUCUGUGCCGGCAG		[3749-3767]
79	CUACAAAGUCCGACAUCCA	UGGAUGUCGGACUUUGUAG		[2491-2509]
					80	AAUCCUUCAUGAAGUACAU	AUGUACUUCAUGAAGGAUU		[1586-1604]
81	AGGCUGUCGUUGAGAUCAA	UUGAUCUCAACGACAGCCU		[1502-1520]
					82	CUGCAGAAUCCUUCAUGAA	UUCAUGAAGGAUUCUGCAG		[1580-1598]
83	UGUUCACCAUGAGGCUCAA	UUGAGCCUCAUGGUGAACA		[2459-2477]
					84	GCUACUGGGUCAGUGACAA	UUGUCACUGACCCAGUAGC		[2696-2714]
85	UGGAGAUAUUUACAUGAAU	AUUCAUGUAAAUAUCUCCA		[4168-4186]
					86	GCGCCUUUGCUCAUGACAU	AUGUCAUGAGCAAAGGCGC	Ms	[2168-2186]
87	AGCUGAAAUUGAAUGAGGA	UCCUCAUUCAAUUUCAGCU		[3569-3587]
					88	GCGUUACUCCACCAACAAU	AUUGUUGGUGGAGUAACGC		[957-975]
89	UGAAGUACAUGCAGAAUGA	UCAUUCUGCAUGUACUUCA		[1595-1613]
					90	GAGUCAGAGUCACCAUCCU	AGGAUGGUGACUCUGACUC		[1871-1889]
91	GAAGUACAUGCAGAAUGAA	UUCAUUCUGCAUGUACUUC		[1596-1614]
					92	GGAGAUAUUUACAUGAAUU	AAUUCAUGUAAAUAUCUCC		[4169-4187]
93	AGGCAAAAAUAGAGGAACA	UGUUCCUCUAUUUUUGCCU	大鼠，Ms	[731-749]
					94	GGCUCAAAUCUCGGCAGAA	UUCUGCCGAGAUUUGAGCC		[2471-2489]
95	UGCUGAUGCGCAAGACAAU	AUUGUCUUGCGCAUCAGCA		[1844-1862]
					96	GGAAAGAAGUCUCCAGAAU	AUUCUGGAGACUUCUUUCC		[454-472]
97	CAGCCUGUGAGACGUUUGA	UCAAACGUCUCACAGGCUG		[2300-2318]

98	ACCUCAGCAAGCAGCAGAA	UUCUGCUGCUUGCUGAGGU		[407-425]
					99	AACUUUGUAGCGAGUCGAA	UUCGACUCGCUACAAAGUU		[3-21]
100	UCAUGAAGUACAUGCAGAA	UUCUGCAUGUACUUCAUGA		[1592-1610]
					101	GGUACAUGGGCACAGAGAU	AUCUCUGUGCCCAUGUACC		[1379-1397]
102	AGCAGAAUGUGACCAUCAU	AUGAUGGUCACAUUCUGCU	大鼠，Ms	[1547-1565]
					103	GACCAAAUUCCACCAGUAU	AUACUGGUGGAAUUUGGUC		[294-312]
104	AUGCCUCUGUAUUUAAAAA	UUUUUAAAUACAGAGGCAU		[4092-4110]
					105	UAUCGAAUUUGUCAACCAA	UUGGUUGACAAAUUCGAUA		[693-711]
106	UGAGCUCAAAUCCAGAUAA	UUAUCUGGAUUUGAGCUCA		[211-229]
					107	UGGAGAGAAACUGAAGAAA	UUUCUUCAGUUUCUCUCCA		[2067-2085]
108	GGUCGAGGACUAUUUCUUU	AAAGAAAUAGUCCUCGACC		[3591-3609]
					109	GACAGAGACAGGAAAAUCA	UGAUUUUCCUGUCUCUGUC		[1896-1914]
110	GCUACAACAUCCUGGAGGA	UCCUCCAGGAUGUUGUAGC	大鼠，Ms	[1427-1445]
					111	UUCGGGAACUGGAGCUAAA	UUUAGCUCCAGUUCCCGAA		[1280-1298]
112	CAAAGGAGAUAGAAACAAC	GUUGUUUCUAUCUCCUUUG		[773-791]
					113	CGUUGAGAUCAACAUUGCU	AGCAAUGUUGAUCUCAACG		[1509-1527]
114	GAGAGAUUCCAUUGAAAGU	ACUUUCAAUGGAAUCUCUC		[1796-1814]
					115	AGGUUGUCUGCAUGGAUAA	UUAUCCAUGCAGACAACCU		[1967-1985]
116	CUCCUUCAAAGAGGCAAAA	UUUUGCCUCUUUGAAGGAG	大鼠	[720-738]
					117	ACCAGGAGAUGCUGAACUA	UAGUUCAGCAUCUCCUGGU		[1694-1712]
118	UCGAAUUUGUCAACCAAUA	UAUUGGUUGACAAAUUCGA		[695-713]
					119	UCAAAGAGGCAAAAAUAGA	UCUAUUUUUGCCUCUUUGA	大鼠	[725-743]
120	AAGAGAAGAGAGAUUCCAU	AUGGAAUCUCUCUUCUCUU		[1789-1807]
					121	UGAAGAAAUCGCUCUUCAU	AUGAAGAGCGAUUUCUUCA		[2078-2096]
122	CUGGUCCCUUGGAGACAAA	UUUGUCUCCAAGGGACCAG		[3947-3965]
					123	CCCGGGAAAUGUUUGAACA	UGUUCAAACAUUUCCCGGG		[923-941]
124	AGGAGGAGAUGCUGGAGAU	AUCUCCAGCAUCUCCUCCU		[3341-3359]

125	UAAGUGACCUGCUUUGUAA	UUACAAAGCAGGUCACUUA		[236-254]
					126	CACAGUGAAGAACAUCUGA	UCAGAUGUUCUUCACUGUG		[195-213]
127	GAAGAGCCUGAGAGACAGA	UCUGUCUCUCAGGCUCUUC		[2818-2836]
					128	GUCCAUUAUGACUCCCAAA	UUUGGGAGUCAUAAUGGAC		[615-633]
129	CCAAGCUCUACACCUCCAA	UUGGAGGUGUAGAGCUUGG		[2348-2366]
					130	CUCAAAUCCAGAUAAGUGA	UCACUUAUCUGGAUUUGAG		[215-233]
131	GAAGCGGUAACAAAGGAGA	UCUCCUUUGUUACCGCUUC		[763-781]
					132	UCGUGGAGACGGGAAAGAA	UUCUUUCCCGUCUCCACGA		[443-461]
133	GAGCUUCUACCUCAAGCUA	UAGCUUGAGGUAGAAGCUC		[676-694]
					134	CAAGAGAAGAGAGAUUCCA	UGGAAUCUCUCUUCUCUUG		[1788-1806]
135	CGUGCAAACCUUCAAGGCA	UGCCUUGAAGGUUUGCACG		[2283-2301]
					136	AGAGGCAAAAAUAGAGGAA	UUCCUCUAUUUUUGCCUCU	大鼠，Ms	[729-747]
137	CAAGGUUGUCUGCAUGGAU	AUCCAUGCAGACAACCUUG		[1965-1983]
					138	AGUGGUUUCGGGAACUGGA	UCCAGUUCCCGAAACCACU		[1274-1292]
139	GAAGCGCUAUCACGAAGAU	AUCUUCGUGAUAGCGCUUC		[3624-3642]
					140	CAUAGUUUCCAGAAGCAGA	UCUGCUUCUGGAAACUAUG	Ms	[1534-1552]
141	CCUUCAUGAAGUACAUGCA	UGCAUGUACUUCAUGAAGG		[1589-1607]
					142	AAGCGGUAACAAAGGAGAU	AUCUCCUUUGUUACCGCUU		[764-782]
143	GAGCUCAAAUCCAGAUAAG	CUUAUCUGGAUUUGAGCUC		[212-230]
					144	UCAGGUAGAGGCCUGGAAA	UUUCCAGGCCUCUACCUGA		[1737-1755]
145	UUAUGCCUCUGUAUUUAAA	UUUAAAUACAGAGGCAUAA		[4090-4108]
					146	AACAAAGGAGAUAGAAACA	UGUUUCUAUCUCCUUUGUU		[771-789]
147	AGUUAUUUAUGCCUCUGUA	UACAGAGGCAUAAAUAACU		[4084-4102]
					148	CUCAUGACAUUGAUCAGAA	UUCUGAUCAAUGUCAUGAG		[2177-2195]
149	AGAGAAGAGAGAUUCCAUU	AAUGGAAUCUCUCUUCUCU		[1790-1808]
					150	CUGAAAGAGCUCAACAACA	UGUUGUUGAGCUCUUUCAG		[2098-2116]
151	CAAAGAGGCAAAAAUAGAG	CUCUAUUUUUGCCUCUUUG	大鼠	[726-744]

152	AGGAGAUGCUGAACUACGU	ACGUAGUUCAGCAUCUCCU		[1697-1715]
					153	AGCCCAAGGUCUAUGUUCA	UGAACAUAGACCUUGGGCU		[3416-3434]
154	GCAGAAUCCUUCAUGAAGU	ACUUCAUGAAGGAUUCUGC		[1582-1600]
					155	GGGUCUUCCCUGUAUGAUU	AAUCAUACAGGGAAGACCC		[4143-4161]
156	GGUCCCUUGGAGACAAAAU	AUUUUGUCUCCAAGGGACC		[3949-3967]
					157	AGAUAAGUGACAUAAGUGA	UCACUUAUGUCACUUAUCU		[224-242]
158	CGAGGACUAUUUCUUUCAG	CUGAAAGAAAUAGUCCUCG		[3594-3612]
					159	GAAAAAGACAUCAACAACA	UGUUGUUGAUGUCUUUUUC		[325-343]
160	CUCCAGAAUCUCUGGUCAA	UUGACCAGAGAUUCUGGAG		[464-482]
					161	GAAUCUACAAAGUCCGACA	UGUCGGACUUUGUAGAUUC		[2487-2505]
162	CCUCUUUGCGACAGAGACA	UGUCUCUGUCGCAAAGAGG		[1887-1905]
					163	CAGAAGAGCCUGAGAGACA	UGUCUCUCAGGCUCUUCUG		[2816-2834]
164	CUUACGAGGCGAAGAAGGA	UCCUUCUUCGCCUCGUAAG		[3662-3680]
					165	CAUCAAGCCCUUUACUUGA	UCAAGUAAAGGGCUUGAUG		[3869-3887]
166	CUACCUCAAGCUAUCGAAU	AUUCGAUAGCUUGAGGUAG		[682-700]
					167	UAUGCCUCUGUAUUUAAAA	UUUUAAAUACAGAGGCAUA		[4091-4109]
168	ACUAUUUCUUUCAGCUCAA	UUGAGCUGAAAGAAAUAGU		[3599-3617]
					169	AAUCCAGAUAAGUGACAUA	UAUGUCACUUAUCUGGAUU		[219-237]
170	GCAGAGAACUCAGCCUCAU	AUGAGGCUGAGUUCUCUGC		[38-56]
					171	UUGGAGACAAAAUCUUAAA	UUUAAGAUUUUGUCUCCAA		[3955-3973]
172	CACAGAACUUAAGGAUGGA	UCCAUCCUUAAGUUCUGUG		[3756-3774]
					173	AAGCUAUCGAAUUUGUCAA	UUGACAAAUUCGAUAGCUU		[689-707]
174	AGUACAUGCAGAAUGAAUA	UAUUCAUUCUGCAUGUACU		[1598-1616]
					175	AAUUUCUGUUCAAGACCAA	UUGGUCUUGAACAGAAAUU		[281-299]
176	AUGGAGAGAAACUGAAGAA	UUCUUCAGUUUCUCUCCAU		[2066-2084]
					177	GGGAUGACUUUCCAAGACA	UGUCUUGGAAAGUCAUCCC		[541-559]
178	CAAGCUCUACACCUCCAAU	AUUGGAGGUGUAGAGCUUG		[2349-2367]

179	CAGAGAACUCAGCCUCAUU	AAUGAGGCUGAGUUCUCUG		[39-57]
					180	AAGUGGAAGUUCACCAACA	UGUUGGUGAACUUCCACUU		[2872-2890]
181	AGAUAUCUUUGGUGCUGUA	UACAGCACCAAAGAUAUCU		[3639-3657]
					182	UCAGCAAGCAGCAGAAUGA	UCAUUCUGCUGCUUGCUGA		[410-428]
183	CUGAAGAAAUCGCUCUUCA	UGAAGAGCGAUUUCUUCAG		[2077-2095]
					184	GGUGGAAGCGGUAACAAAG	CUUUGUUACCGCUUCCACC		[759-777]
185	AAAGGGAUUUUAACUUGCA	UGCAAGUUAAAAUCCCUUU		[577-595]
					186	CCCUUUACUUGACCUCCUA	UAGGAGGUCAAGUAAAGGG		[3876-3894]
187	CACCUGACCUUGUGCUUGA	UCAAGCACAAGGUCAGGUG		[1229-1247]
					188	AGCGGUAACAAAGGAGAUA	UAUCUCCUUUGUUACCGCU		[765-783]
189	CGUUUGAUGUCCGAGGCAA	UUGCCUCGGACAUCAAACG		[2312-2330]
					190	AGAACAUCUGAGCUCAAAU	AUUUGAGCUCAGAUGUUCU		[203-221]
191	UGACCAUCAUGGACCACCA	UGGUGGUCCAUGAUGGUCA	大鼠，Ms	[1556-1574]
					192	UCAACAACAAUGUGGAGAA	UUCUCCACAUUGUUGUUGA		[335-353]
193	CGGGAACUGGAGCUAAAGU	ACUUUAGCUCCAGUUCCCG		[1282-1300]
					194	GAGAGAAACUGAAGAAAUC	GAUUUCUUCAGUUUCUCUC		[2069-2087]
195	AGUUCUAGACAGUCCCGAA	UUCGGGACUGUCUAGAACU		[102-120]
					196	AGACCCAAGAGAAGAGAGA	UCUCUCUUCUCUUGGGUCU		[1783-1801]
197	GACCCAAGAGAAGAGAGAU	AUCUCUCUUCUCUUGGGUC		[1784-1802]
					198	CAUUAUGACUCCCAAAAGU	ACUUUUGGGAGUCAUAAUG		[618-636]
199	AUGGAGAUAUUUACAUGAA	UUCAUGUAAAUAUCUCCAU		[4167-4185]
					200	UGGAAGCGGUAACAAAGGA	UCCUUUGUUACCGCUUCCA		[761-779]
201	CCGGCACAGAACUUAAGGA	UCCUUAAGUUCUGUGCCGG		[3752-3770]
					202	CCUCUGUAUUUAAAAAACU	AGUUUUUUAAAUACAGAGG		[4095-4113]
203	CCCUCCAGAUGAGCUUCUA	UAGAAGCUCAUCUGGAGGG		[666-684]
					204	GAGAUGGAGGAAAGUGAUA	UAUCACUUUCCUCCAUCUC		[3811-3829]
205	CCAUCCUCUUUGCGACAGA	UCUGUCGCAAAGAGGAUGG		[1883-1901]

206	AAUCUCUGGUCAAGCUGGA	UCCAGCUUGACCAGAGAUU		[470-488]
					207	AGGAGAAUGGGCCUGGAAA	UUUCCAGGCCCAUUCUCCU		[1453-1471]
208	ACAGGAUGACCUUCAGUAU	AUACUGAAGGUCAUCCUGU		[384-402]
					209	AUAGUUUCCAGAAGCAGAA	UUCUGCUUCUGGAAACUAU	Ms	[1535-1553]
210	GAUGGAGAUAUUUACAUGA	UCAUGUAAAUAUCUCCAUC		[4166-4184]
					211	UGCGACAGAGACAGGAAAA	UUUUCCUGUCUCUGUCGCA		[1893-1911]
212	UGACCCUGAGCUCUUCGAA	UUCGAAGAGCUCAGGGUCA		[1206-1224]
					213	AAUAUUACGGCUCCUUCAA	UUGAAGGAGCCGUAAUAUU		[710-728]
214	ACAUCUGAGCUCAAAUCCA	UGGAUUUGAGCUCAGAUGU		[206-224]
					215	ACUUUGUAGCGAGUCGAAA	UUUCGACUCGCUACAAAGU		[4-22]
216	CAGAAUCUACAAAGUCCGA	UCGGACUUUGUAGAUUCUG		[2485-2503]
					217	CCUACUUCCUGGACAUCAC	GUGAUGUCCAGGAAGUAGG	大鼠	[2750-2768]
218	AGGGUGGAAGCGGUAACAA	UUGUUACCGCUUCCACCCU		[757-775]
					219	CCAUGGAACAUCCCAAAUA	UAUUUGGGAUGUUCCAUGG		[1253-1271]
220	UGGAAAUUUCUGUUCAAGA	UCUUGAACAGAAAUUUCCA		[277-295]
					221	UCGGCAGAAUCUACAAAGU	ACUUUGUAGAUUCUGCCGA		[2481-2499]
222	UUGUCUGCAUGGAUAAGUA	UACUUAUCCAUGCAGACAA		[1970-1988]
					223	CACAGGAUGACCUUCAGUA	UACUGAAGGUCAUCCUGUG		[383-401]
224	UCACCUACUUCCUGGACAU	AUGUCCAGGAAGUAGGUGA	大鼠，Ms	[2747-2765]
					225	GGAACUCUCCUGUGAGGAU	AUCCUCACAGGAGAGUUCC		[2529-2547]
226	CCGUGUUUCACCAGGAGAU	AUCUCCUGGUGAAACACGG		[1685-1703]
					227	AAGGUUGUCUGCAUGGAUA	UAUCCAUGCAGACAACCUU		[1966-1984]
228	UGCUGAGUGCACCACUUCA	UGAAGUGGUGCACUCAGCA		[4011-4029]
					229	CAGAUGAGGACCACAUCUA	UAGAUGUGGUCCUCAUCUG		[3320-3338]
230	GGCUCCUUCAAAGAGGCAA	UUGCCUCUUUGAAGGAGCC	大鼠	[718-736]
					231	CUUGAUGGAGAUAUUUACA	UGUAAAUAUCUCCAUCAAG		[4163-4181]
232	UGCCUCUGUAUUUAAAAAA	UUUUUUAAAUACAGAGGCA		[4093-4111]

233	CCAGCUCUGCAUUAUCUGA	UCAGAUAAUGCAGAGCUGG		[3776-3794]
					234	AUGCUGAUGCGCAAGACAA	UUGUCUUGCGCAUCAGCAU		[1843-1861]
235	GGAUGACCUUCAGUAUCAC	GUGAUACUGAAGGUCAUCC		[387-405]
					236	CUCUACACCUCCAAUGUGA	UCACAUUGGAGGUGUAGAG		[2353-2371]
237	AUAUUACGGCUCCUUCAAA	UUUGAAGGAGCCGUAAUAU		[711-729]
					238	GCUCAAAUCUCGGCAGAAU	AUUCUGCCGAGAUUUGAGC		[2472-2490]
239	CAGAUGAGCUUCUACCUCA	UGAGGUAGAAGCUCAUCUG		[671-689]
					240	CAUUCCUGGAGGUGCUAGA	UCUAGCACCUCCAGGAAUG		[2897-2915]
241	CGGCACAGAACUUAAGGAU	AUCCUUAAGUUCUGUGCCG		[3753-3771]
					242	GAUAUUUACAUGAAUUGCA	UGCAAUUCAUGUAAAUAUC		[4172-4190]
243	CCUUGAUGGAGAUAUUUAC	GUAAAUAUCUCCAUCAAGG		[4162-4180]
					244	UCUACCUCAAGCUAUCGAA	UUCGAUAGCUUGAGGUAGA		[681-699]
245	ACAAAGGAGAUAGAAACAA	UUGUUUCUAUCUCCUUUGU		[772-790]
					246	AAGAACAUCUGAGCUCAAA	UUUGAGCUCAGAUGUUCUU		[202-220]
247	CCAUGAGGCUCAAAUCUCG	CGAGAUUUGAGCCUCAUGG		[2465-2483]
					248	GGCAAAAAUAGAGGAACAU	AUGUUCCUCUAUUUUUGCC	大鼠，Ms	[732-750]
249	GAUGGAACUUGCUGCUGAG	CUCAGCAGCAAGUUCCAUC		[3999-4017]
					250	CAAAUUCCACCAGUAUGCA	UGCAUACUGGUGGAAUUUG		[297-315]
251	CCUUUACUUGACCUCCUAA	UUAGGAGGUCAAGUAAAGG		[3877-3895]
					252	AUAUUUACAUGAAUUGCAU	AUGCAAUUCAUGUAAAUAU		[4173-4191]
253	AGGCAAACAGCACAUUCAG	CUGAAUGUGCUGUUUGCCU		[2325-2343]
					254	CGGGAGAUGAGCUCAUCUU	AAGAUGAGCUCAUCUCCCG		[809-827]
255	CUGAGCUCAAAUCCAGAUA	UAUCUGGAUUUGAGCUCAG		[210-228]
					256	GGAGACCCAAGAGAAGAGA	UCUCUUCUCUUGGGUCUCC		[1781-1799]
257	GGUGGUGACCAGUACGUUU	AAACGUACUGGUCACCACC		[2025-2043]
					258	ACAUCAACAACAAUGUGGA	UCCACAUUGUUGUUGAUGU		[332-350]
259	AGUGGAAGUUCACCAACAG	CUGUUGGUGAACUUCCACU		[2873-2891]

260	AAAUUCCACCAGUAUGCAA	UUGCAUACUGGUGGAAUUU		[298-316]
					261	CCAAGGUUGUCUGCAUGGA	UCCAUGCAGACAACCUUGG	大鼠，Ms	[1964-1982]
262	AGCGCUACAACAUCCUGGA	UCCAGGAUGUUGUAGCGCU	大鼠，Ms	[1424-1442]
					263	CAACAUUGCUGUGCUCCAU	AUGGAGCACAGCAAUGUUG		[1518-1536]
264	AUCUCGGCAGAAUCUACAA	UUGUAGAUUCUGCCGAGAU		[2478-2496]
					265	CAGCAAGCAGCAGAAUGAG	CUCAUUCUGCUGCUUGCUG		[411-429]
266	CUAUCGAAUUUGUCAACCA	UGGUUGACAAAUUCGAUAG		[692-710]
					267	CAGAAUCUCUGGUCAAGCU	AGCUUGACCAGAGAUUCUG		[467-485]
268	CCUUGGAAAUUUCUGUUCA	UGAACAGAAAUUUCCAAGG		[274-292]
					269	AACUGGAGCUAAAGUGGUA	UACCACUUUAGCUCCAGUU		[1286-1304]
270	AGGAUGACCUUCAGUAUCA	UGAUACUGAAGGUCAUCCU		[386-404]
					271	UAACAAGUAGCACCCUGGA	UCCAGGGUGCUACUUGUUA		[3893-3911]
272	UGUGGAAUGCUCAGCUCAU	AUGAGCUGAGCAUUCCACA		[1040-1058]
					273	GCCUCUGUAUUUAAAAAAC	GUUUUUUAAAUACAGAGGC		[4094-4112]
274	GCUUCUACCUCAAGCUAUC	GAUAGCUUGAGGUAGAAGC		[678-696]
					275	GAUGACCUUCAGUAUCACA	UGUGAUACUGAAGGUCAUC		[388-406]
276	AUCUGAGCUCAAAUCCAGA	UCUGGAUUUGAGCUCAGAU		[208-226]
					277	ACCUCAAGCUAUCGAAUUU	AAAUUCGAUAGCUUGAGGU		[684-702]
278	UUGCGACAGAGACAGGAAA	UUUCCUGUCUCUGUCGCAA		[1892-1910]
					279	CCAACAUGCUGCUUGAGGU	ACCUCAAGCAGCAUGUUGG		[1322-1340]
280	CAUGGAACAUCCCAAAUAC	GUAUUUGGGAUGUUCCAUG		[1254-1272]
					281	CUCAUUCCUGCUUUAAAAU	AUUUUAAAGCAGGAAUGAG		[52-70]
282	CGGCUGCAGAAUCCUUCAU	AUGAAGGAUUCUGCAGCCG		[1577-1595]
					283	CAGUAUCACAACCUCAGCA	UGCUGAGGUUGUGAUACUG		[397-415]
284	AGCUCAAAUCCAGAUAAGU	ACUUAUCUGGAUUUGAGCU		[213-231]
					285	GCGACAGAGACAGGAAAAU	AUUUUCCUGUCUCUGUCGC		[1894-1912]
286	AAACAACAGGAACCUACCA	UGGUAGGUUCCUGUUGUUU	大鼠，Ms	[785-803]

287	UAUUCAGCUGUGCCUUCAA	UUGAAGGCACAGCUGAAUA		[1943-1961]
					288	GGAUGACUUUCCAAGACAC	GUGUCUUGGAAAGUCAUCC		[542-560]
289	AGAAGAGAGAUUCCAUUGA	UCAAUGGAAUCUCUCUUCU		[1792-1810]
					290	GGAAAUUUCUGUUCAAGAC	GUCUUGAACAGAAAUUUCC		[278-296]
291	UUCCUUACGAGGCGAAGAA	UUCUUCGCCUCGUAAGGAA		[3659-3677]
					292	CCACUUCAAGUGACCACCA	UGGUGGUCACUUGAAGUGG		[4022-4040]
293	ACAACAUCCUGGAGGAAGU	ACUUCCUCCAGGAUGUUGU	大鼠，Ms	[1430-1448]
					294	UCGGCUGCAGAAUCCUUCA	UGAAGGAUUCUGCAGCCGA		[1576-1594]
295	CCGAAGUUCUCAAGGCACA	UGUGCCUUGAGAACUUCGG		[116-134]
					296	UAAAGCUGCCGGCACAGAA	UUCUGUGCCGGCAGCUUUA		[3744-3762]
297	CAAUGGAGAGAAACUGAAG	CUUCAGUUUCUCUCCAUUG		[2064-2082]
					298	AAUGGAGAGAAACUGAAGA	UCUUCAGUUUCUCUCCAUU		[2065-2083]
299	UGGUGGAACUCUCCUGUGA	UCACAGGAGAGUUCCACCA		[2525-2543]
					300	CUUCAGUAUCACAACCUCA	UGAGGUUGUGAUACUGAAG		[394-412]
301	CCCUGUAUGAUUCCUUGAU	AUCAAGGAAUCAUACAGGG		[4150-4168]
					302	AGGUCUAUGUUCAGGACAU	AUGUCCUGAACAUAGACCU		[3422-3440]
303	CAUCUGAGCUCAAAUCCAG	CUGGAUUUGAGCUCAGAUG		[207-225]
					304	CUCUUUGCCUGUAUGCUGA	UCAGCAUACAGGCAAAGAG		[1831-1849]
305	GAAUCCUUCAUGAAGUACA	UGUACUUCAUGAAGGAUUC		[1585-1603]
					306	CCUGGUUUGACUGUCCUUA	UAAGGACAGUCAAACCAGG		[143-161]
307	CUCAAGCUAUCGAAUUUGU	ACAAAUUCGAUAGCUUGAG		[686-704]
					308	CUACAACAUCCUGGAGGAA	UUCCUCCAGGAUGUUGUAG	大鼠，Ms	[1428-1446]
309	CUUCAAGUGACCACCAGGA	UCCUGGUGGUCACUUGAAG		[4025-4043]
					310	CCCUUGGAGACAAAAUCUU	AAGAUUUUGUCUCCAAGGG		[3952-3970]
311	AAAGAAGUCUCCAGAAUCU	AGAUUCUGGAGACUUCUUU		[456-474]
					312	GCAAACAGCACAUUCAGAU	AUCUGAAUGUGCUGUUUGC		[2327-2345]
313	GACUGGGCAGUUCUAGACA	UGUCUAGAACUGCCCAGUC		[94-112]

314	AAAAGACAUCAACAACAAU	AUUGUUGUUGAUGUCUUUU		[327-345]
					315	CUGAGUGCACCACUUCAAG	CUUGAAGUGGUGCACUCAG		[4013-4031]
316	CAAAUCUCGGCAGAAUCUA	UAGAUUCUGCCGAGAUUUG		[2475-2493]
					317	UCAUGCUGAAAGAGCUCAA	UUGAGCUCUUUCAGCAUGA		[2093-2111]
318	UGGUCCCUUGGAGACAAAA	UUUUGUCUCCAAGGGACCA		[3948-3966]
					319	CCAAGCUGAAAUUGAAUGA	UCAUUCAAUUUCAGCUUGG		[3566-3584]
320	CCAAGGUCUAUGUUCAGGA	UCCUGAACAUAGACCUUGG		[3419-3437]
					321	CAGAGAUCCACCUGACUGU	ACAGUCAGGUGGAUCUCUG		[3020-3038]
322	CUUCCUGGACAUCACCACA	UGUGGUGAUGUCCAGGAAG		[2754-2772]
					323	GCGCUAUCACGAAGAUAUC	GAUAUCUUCGUGAUAGCGC		[3627-3645]
324	UGGAGACAAAAUCUUAAAU	AUUUAAGAUUUUGUCUCCA		[3956-3974]
					325	CACAGAGAUCCACCUGACU	AGUCAGGUGGAUCUCUGUG		[3018-3036]
326	CGGGAUGACUUUCCAAGAC	GUCUUGGAAAGUCAUCCCG		[540-558]
					327	GUCUCUUCCUGGUUUGACU	AGUCAAACCAGGAAGAGAC		[136-154]
328	CUAUCACGAAGAUAUCUUU	AAAGAUAUCUUCGUGAUAG		[3630-3648]
					329	CUGUCGUUGAGAUCAACAU	AUGUUGAUCUCAACGACAG		[1505-1523]
330	AGGACUCACAGCCUUUGGA	UCCAAAGGCUGUGAGUCCU		[2402-2420]
					331	UCCUUCAAAGAGGCAAAAA	UUUUUGCCUCUUUGAAGGA	大鼠	[721-739]
332	AGUAUCACAACCUCAGCAA	UUGCUGAGGUUGUGAUACU		[398-416]
					333	UGAGCUCUUCGAAAUCCCA	UGGGAUUUCGAAGAGCUCA		[1212-1230]
334	CAAGUGGGUGAAAGAUGGA	UCCAUCUUUCACCCACUUG		[3986-4004]
					335	CAACCUGCAGGUCUUCGAU	AUCGAAGACCUGCAGGUUG	大鼠	[885-903]
336	AGCGCUAUCACGAAGAUAU	AUAUCUUCGUGAUAGCGCU		[3626-3644]
					337	GAAAGACCAGGCUGUCGUU	AACGACAGCCUGGUCUUUC		[1494-1512]
338	CUGGGCAGUUCUAGACAGU	ACUGUCUAGAACUGCCCAG		[96-114]
					339	CAAAAAUAGAGGAACAUCU	AGAUGUUCCUCUAUUUUUG	大鼠，Ms	[734-752]
340	CAGAGUCACCAUCCUCUUU	AAAGAGGAUGGUGACUCUG		[1875-1893]

341	ACUUGCAGGUCCAAAUCUU	AAGAUUUGGACCUGCAAGU		[589-607]
					342	AAUUUGUCAACCAAUAUUA	UAAUAUUGGUUGACAAAUU		[698-716]
343	CAGGAACCUACCAACUGAC	GUCAGUUGGUAGGUUCCUG		[791-809]
					344	GCACCACUUCAAGUGACCA	UGGUCACUUGAAGUGGUGC		[4019-4037]
345	UGAGACGUUUGAUGUCCGA	UCGGACAUCAAACGUCUCA		[2307-2325]
					346	GCCCAAGGUCUAUGUUCAG	CUGAACAUAGACCUUGGGC		[3417-3435]
347	AGGACCACAUCUACCAGGA	UCCUGGUAGAUGUGGUCCU		[3326-3344]
					348	UGGUACAUGGGCACAGAGA	UCUCUGUGCCCAUGUACCA		[1378-1396]
349	GUGCUGUAUUUCCUUACGA	UCGUAAGGAAAUACAGCAC		[3650-3668]
					350	UAACAAAGGAGAUAGAAAC	GUUUCUAUCUCCUUUGUUA		[770-788]
351	CCUUUGCUCAUGACAUUGA	UCAAUGUCAUGAGCAAAGG		[2171-2189]
					352	CUGUAUUUAAAAAACUAAC	GUUAGUUUUUUAAAUACAG		[4098-4116]
353	GGAAAAAGACAUCAACAAC	GUUGUUGAUGUCUUUUUCC		[324-342]
					354	AGAAUGUGACCAUCAUGGA	UCCAUGAUGGUCACAUUCU	大鼠，Ms	[1550-1568]
355	GUGGAGACGGGAAAGAAGU	ACUUCUUUCCCGUCUCCAC		[445-463]
					356	UUAACUUGCAGGUCCAAAU	AUUUGGACCUGCAAGUUAA		[586-604]
357	UUACUUGACCUCCUAACAA	UUGUUAGGAGGUCAAGUAA		[3880-3898]
					358	ACGUGUUCACCAUGAGGCU	AGCCUCAUGGUGAACACGU	大鼠	[2456-2474]
359	CCCAGGUUCUACUCCAUCA	UGAUGGAGUAGAACCUGGG		[2977-2995]
					360	CUGCCCGGGAAAUGUUUGA	UCAAACAUUUCCCGGGCAG		[920-938]
361	CCCUCAGAGUACAGCAAGU	ACUUGCUGUACUCUGAGGG		[2857-2875]
					362	GUUCACCAUGAGGCUCAAA	UUUGAGCCUCAUGGUGAAC		[2460-2478]
363	GAAUUUGUCAACCAAUAUU	AAUAUUGGUUGACAAAUUC		[697-715]
					364	AAGAGGCAAAAAUAGAGGA	UCCUCUAUUUUUGCCUCUU	大鼠，Ms	[728-746]
365	UUGGGUCUUCCCUGUAUGA	UCAUACAGGGAAGACCCAA		[4141-4159]
					366	CCAUUAUGACUCCCAAAAG	CUUUUGGGAGUCAUAAUGG		[617-635]
367	GGAACAUCCCAAAUACGAG	CUCGUAUUUGGGAUGUUCC		[1257-1275]

368	AGAGAGAUUCCAUUGAAAG	CUUUCAAUGGAAUCUCUCU		[1795-1813]
					369	UCAUGACAUUGAUCAGAAG	CUUCUGAUCAAUGUCAUGA		[2178-2196]
370	AGAACGUGUUCACCAUGAG	CUCAUGGUGAACACGUUCU	大鼠	[2453-2471]
					371	UAUGCUGAUGCGCAAGACA	UGUCUUGCGCAUCAGCAUA		[1842-1860]
372	ACGUGCGUUACUCCACCAA	UUGGUGGAGUAACGCACGU		[953-971]
					373	UGGUCAAGCUGGAUGCAAC	GUUGCAUCCAGCUUGACCA		[476-494]
374	GAGCUCAACAACAAAUUCA	UGAAUUUGUUGUUGAGCUC		[2104-2122]
					375	AGCUGCUGCUCCAAAAGCU	AGCUUUUGGAGCAGCAGCU		[2783-2801]
376	CACCAUGAGGCUCAAAUCU	AGAUUUGAGCCUCAUGGUG		[2463-2481]
					377	CCUGGAAAACCCAUGUCUG	CAGACAUGGGUUUUCCAGG		[1748-1766]
378	UGACGGGAGAUGAGCUCAU	AUGAGCUCAUCUCCCGUCA		[806-824]
					379	GCUCAAAUCCAGAUAAGUG	CACUUAUCUGGAUUUGAGC		[214-232]
380	CGUUACUCCACCAACAAUG	CAUUGUUGGUGGAGUAACG		[958-976]
					381	CUUGACCUCCUAACAAGUA	UACUUGUUAGGAGGUCAAG		[3883-3901]
382	GCAGGUCGAGGACUAUUUC	GAAAUAGUCCUCGACCUGC		[3588-3606]
					383	CUGGUCAAGCUGGAUGCAA	UUGCAUCCAGCUUGACCAG		[475-493]
384	AUGACCUUCAGUAUCACAA	UUGUGAUACUGAAGGUCAU		[389-407]
					385	UGACCUUCAGUAUCACAAC	GUUGUGAUACUGAAGGUCA		[390-408]
386	AGUGCACCACUUCAAGUGA	UCACUUGAAGUGGUGCACU		[4016-4034]
					387	CAACAGGAACCUACCAACU	AGUUGGUAGGUUCCUGUUG		[788-806]
388	GACUAUUUCUUUCAGCUCA	UGAGCUGAAAGAAAUAGUC		[3598-3616]
					389	UGAAGAACAUCUGAGCUCA	UGAGCUCAGAUGUUCUUCA		[200-218]
390	AUUACGGCUCCUUCAAAGA	UCUUUGAAGGAGCCGUAAU		[713-731]
					391	GCAUGUGAGGAUCAAAAAC	GUUUUUGAUCCUCACAUGC		[513-531]
392	AUAAGUGACCUGCUUUGUA	UACAAAGCAGGUCACUUAU		[235-253]
					393	CCAGCCUCAAGUCUUAUUU	AAAUAAGACUUGAGGCUGG		[3834-3852]
394	CAUCAACAACAAUGUGGAG	CUCCACAUUGUUGUUGAUG		[333-351]

395	AGCCCAGGUUCUACUCCAU	AUGGAGUAGAACCUGGGCU		[2975-2993]
					396	CACCAUCCUCUUUGCGACA	UGUCGCAAAGAGGAUGGUG		[1881-1899]
397	UAGCGAGUCGAAAACUGAG	CUCAGUUUUCGACUCGCUA		[10-28]
					398	CAUUGCUGUGCUCCAUAGU	ACUAUGGAGCACAGCAAUG		[1521-1539]
399	UCCAUGACUCCCAGCACAA	UUGUGCUGGGAGUCAUGGA	Ms	[3254-3272]
					400	AUUUUAACUUGCAGGUCCA	UGGACCUGCAAGUUAAAAU		[583-601]
401	UCCACCAGUAUGCAAUGAA	UUCAUUGCAUACUGGUGGA		[302-320]
					402	ACAUCUACCAGGAGGAGAU	AUCUCCUCCUGGUAGAUGU		[3332-3350]
403	AAGCGCUAUCACGAAGAUA	UAUCUUCGUGAUAGCGCUU		[3625-3643]
					404	AGAUGGAACUUGCUGCUGA	UCAGCAGCAAGUUCCAUCU		[3998-4016]
405	GAGCCUCCUCUCUCAAACU	AGUUUGAGAGAGGAGGCUC		[3919-3937]
					406	ACAACCUCAGCAAGCAGCA	UGCUGCUUGCUGAGGUUGU		[404-422]
407	CGAAAUCCCACCUGACCUU	AAGGUCAGGUGGGAUUUCG		[1221-1239]
					408	AGAUGAGGACCACAUCUAC	GUAGAUGUGGUCCUCAUCU		[3321-3339]
409	CAUGAAGUACAUGCAGAAU	AUUCUGCAUGUACUUCAUG		[1593-1611]
					410	UGCGCCUUUGCUCAUGACA	UGUCAUGAGCAAAGGCGCA	Ms	[2167-2185]
411	ACCCUGAGCUCUUCGAAAU	AUUUCGAAGAGCUCAGGGU		[1208-1226]
					412	GACGGGAAAGAAGUCUCCA	UGGAGACUUCUUUCCCGUC		[450-468]
413	CUGUGCUCUUUGCCUGUAU	AUACAGGCAAAGAGCACAG		[1826-1844]
					414	AUUUCUGUUCAAGACCAAA	UUUGGUCUUGAACAGAAAU		[282-300]
415	GAGAUUCCAUUGAAAGUCU	AGACUUUCAAUGGAAUCUC		[1798-1816]
					416	CUACCAACUGACGGGAGAU	AUCUCCCGUCAGUUGGUAG		[798-816]
417	CCGGGAAAUGUUUGAACAC	GUGUUCAAACAUUUCCCGG		[924-942]
					418	CCUCAGCAAGCAGCAGAAU	AUUCUGCUGCUUGCUGAGG		[408-426]
419	GCUCCAUAGUUUCCAGAAG	CUUCUGGAAACUAUGGAGC	Ms	[1530-1548]
					420	UCUCGGCAGAAUCUACAAA	UUUGUAGAUUCUGCCGAGA		[2479-2497]
421	UUUAUGCCUCUGUAUUUAA	UUAAAUACAGAGGCAUAAA		[4089-4107]

422	GCAUGACCUUGGUGUUUGG	CCAAACACCAAGGUCAUGC	大鼠	[3290-3308]
					423	AGCUCUACACCUCCAAUGU	ACAUUGGAGGUGUAGAGCU		[2351-2369]
424	CUGUUGGUGGUGACCAGUA	UACUGGUCACCACCAACAG		[2020-2038]
					425	CGGCAGAAUCUACAAAGUC	GACUUUGUAGAUUCUGCCG		[2482-2500]
426	CAAAUCCAGAUAAGUGACA	UGUCACUUAUCUGGAUUUG		[217-235]
					427	ACUUGACCUCCUAACAAGU	ACUUGUUAGGAGGUCAAGU		[3882-3900]
428	CGAAGAUAUCUUUGGUGCU	AGCACCAAAGAUAUCUUCG		[3636-3654]
					429	AGCUACUGGGUCAGUGACA	UGUCACUGACCCAGUAGCU		[2695-2713]
430	AGGCUCAAAUCUCGGCAGA	UCUGCCGAGAUUUGAGCCU		[2470-2488]
					431	AGAAGAGCCUGAGAGACAG	CUGUCUCUCAGGCUCUUCU		[2817-2835]
432	CCAAGAGAAGAGAGAUUCC	GGAAUCUCUCUUCUCUUGG		[1787-1805]
					433	AUUCCUUGAUGGAGAUAUU	AAUAUCUCCAUCAAGGAAU		[4159-4177]
434	UCCAGAUAAGUGACAUAAG	CUUAUGUCACUUAUCUGGA		[221-239]
					435	UCCAUAGUUUCCAGAAGCA	UGCUUCUGGAAACUAUGGA	Ms	[1532-1550]
436	AGCCCUCAGAGUACAGCAA	UUGCUGUACUCUGAGGGCU		[2855-2873]
					437	UGACAUAAGUGACCUGCUU	AAGCAGGUCACUUAUGUCA		[231-249]
438	CAGGUCGAGGACUAUUUCU	AGAAAUAGUCCUCGACCUG		[3589-3607]
					439	UGUCGUUGAGAUCAACAUU	AAUGUUGAUCUCAACGACA		[1506-1524]
440	GAAACAACAGGAACCUACC	GGUAGGUUCCUGUUGUUUC	大鼠，Ms	[784-802]
					441	GCUGAAAUUGAAUGAGGAG	CUCCUCAUUCAAUUUCAGC		[3570-3588]
442	GUGUGGAAUGCUCAGCUCA	UGAGCUGAGCAUUCCACAC		[1039-1057]
					443	AGGUCGAGGACUAUUUCUU	AAGAAAUAGUCCUCGACCU		[3590-3608]
444	AAGAACGUGUUCACCAUGA	UCAUGGUGAACACGUUCUU	大鼠	[2452-2470]
					445	CCCAGCCUCAAGUCUUAUU	AAUAAGACUUGAGGCUGGG		[3833-3851]
446	AGACACGUGCGUUACUCCA	UGGAGUAACGCACGUGUCU		[949-967]
					447	GGUCAAAGCUGUGCUCUUU	AAAGAGCACAGCUUUGACC		[1818-1836]
448	AAGGAGAUAGAAACAACAG	CUGUUGUUUCUAUCUCCUU		[775-793]

449	UGCUCAGCUCAUCCGCUAU	AUAGCGGAUGAGCUGAGCA		[1047-1065]
					450	GCUCAUGACAUUGAUCAGA	UCUGAUCAAUGUCAUGAGC		[2176-2194]
451	CAUUCCUGCUUUAAAAUCU	AGAUUUUAAAGCAGGAAUG		[54-72]
					452	AGCAGGUCGAGGACUAUUU	AAAUAGUCCUCGACCUGCU		[3587-3605]
453	GUUAUUUAUGCCUCUGUAU	AUACAGAGGCAUAAAUAAC		[4085-4103]
					454	GCUGAAAGAGCUCAACAAC	GUUGUUGAGCUCUUUCAGC		[2097-2115]
455	AUGUGACCAUCAUGGACCA	UGGUCCAUGAUGGUCACAU	大鼠，Ms	[1553-1571]
					456	UCACGAAGAUAUCUUUGGU	ACCAAAGAUAUCUUCGUGA		[3633-3651]
457	UCUGCAGACACGUGCGUUA	UAACGCACGUGUCUGCAGA		[944-962]
					458	AGCUUCUACCUCAAGCUAU	AUAGCUUGAGGUAGAAGCU		[677-695]
459	GGCUGUCGUUGAGAUCAAC	GUUGAUCUCAACGACAGCC		[1503-1521]
					460	AGCUCAACAACAAAUUCAG	CUGAAUUUGUUGUUGAGCU		[2105-2123]
461	GGAAGCGGUAACAAAGGAG	CUCCUUUGUUACCGCUUCC		[762-780]
					462	CCAGAUGAGGACCACAUCU	AGAUGUGGUCCUCAUCUGG		[3319-3337]
463	AUACGAGUGGUUUCGGGAA	UUCCCGAAACCACUCGUAU		[1269-1287]
					464	UCAGAGUCACCAUCCUCUU	AAGAGGAUGGUGACUCUGA		[1874-1892]
465	CAAGCCCAAGGUCUAUGUU	AACAUAGACCUUGGGCUUG		[3414-3432]
					466	AUGCUCAGCUCAUCCGCUA	UAGCGGAUGAGCUGAGCAU		[1046-1064]
467	CCUUCAGUAUCACAACCUC	GAGGUUGUGAUACUGAAGG		[393-411]
					468	CUGGUUUGACUGUCCUUAC	GUAAGGACAGUCAAACCAG		[144-162]
469	UAGAAACAACAGGAACCUA	UAGGUUCCUGUUGUUUCUA	大鼠，Ms	[782-800]
					470	CACUUGGGUCUUCCCUGUA	UACAGGGAAGACCCAAGUG		[4138-4156]
471	GAGUCACCAUCCUCUUUGC	GCAAAGAGGAUGGUGACUC		[1877-1895]
					472	CUAUGUUCAGGACAUCCUG	CAGGAUGUCCUGAACAUAG		[3426-3444]
473	GUUCAAGACCAAAUUCCAC	GUGGAAUUUGGUCUUGAAC		[288-306]
					474	AGCCUCAUUCCUGCUUUAA	UUAAAGCAGGAAUGAGGCU		[49-67]
475	AUGUGAGGAUCAAAAACUG	CAGUUUUUGAUCCUCACAU	Ms	[515-533]

476	AAGGUAUCCUGGAGCGAGU	ACUCGCUCCAGGAUACCUU		[2618-2636]
					477	UCUUCGAAAUCCCACCUGA	UCAGGUGGGAUUUCGAAGA		[1217-1235]
478	AAGCAGAAUGUGACCAUCA	UGAUGGUCACAUUCUGCUU	大鼠，Ms	[1546-1564]
					479	GCGGUAACAAAGGAGAUAG	CUAUCUCCUUUGUUACCGC		[766-784]
480	GUAGCACCCUGGAUUGAUC	GAUCAAUCCAGGGUGCUAC		[3899-3917]
					481	GAGCAGGUCGAGGACUAUU	AAUAGUCCUCGACCUGCUC		[3586-3604]
482	AACAACAGGAACCUACCAA	UUGGUAGGUUCCUGUUGUU		[786-804]
					483	GCCUCAAGUCUUAUUUCCU	AGGAAAUAAGACUUGAGGC		[3837-3855]
484	UGGUCCAAGGUAUCCUGGA	UCCAGGAUACCUUGGACCA		[2612-2630]
					485	AUCGAAUUUGUCAACCAAU	AUUGGUUGACAAAUUCGAU		[694-712]
486	UGAGCUUCUACCUCAAGCU	AGCUUGAGGUAGAAGCUCA		[675-693]
					487	AAGGGAUUUUAACUUGCAG	CUGCAAGUUAAAAUCCCUU		[578-596]
488	ACGUCCAGCGCUACAACAU	AUGUUGUAGCGCUGGACGU		[1418-1436]
					489	UUCUGUUCAAGACCAAAUU	AAUUUGGUCUUGAACAGAA		[284-302]
490	AAAUUUCUGUUCAAGACCA	UGGUCUUGAACAGAAAUUU		[280-298]
					491	GGUGAAAGAUGGAACUUGC	GCAAGUUCCAUCUUUCACC		[3992-4010]
492	UUCAAAGAGGCAAAAAUAG	CUAUUUUUGCCUCUUUGAA	大鼠	[724-742]
					493	CAAAAGUUUGACCAGAGGA	UCCUCUGGUCAAACUUUUG		[630-648]
494	CUUUGGUGCUGUAUUUCCU	AGGAAAUACAGCACCAAAG		[3645-3663]
					495	CGCUAUCACGAAGAUAUCU	AGAUAUCUUCGUGAUAGCG		[3628-3646]
496	GCAGAAUGUGACCAUCAUG	CAUGAUGGUCACAUUCUGC	大鼠，Ms	[1548-1566]
					497	CCAGGAGAUGCUGAACUAC	GUAGUUCAGCAUCUCCUGG		[1695-1713]
498	CCAACGUGGAAUUCACUCA	UGAGUGAAUUCCACGUUGG		[1109-1127]
					499	ACAGAGACAGGAAAAUCAG	CUGAUUUUCCUGUCUCUGU		[1897-1915]
500	CCAGGUUCUACUCCAUCAG	CUGAUGGAGUAGAACCUGG		[2978-2996]

表B 24P53-肿瘤蛋白p53

No.

正义链siRNA

反义链siRNA

其他Sp

人-8400737：252-1433

1	CAUUGUGAGGGUUAAUGAA	UUCAUUAACCCUCACAAUG		[1861-1879]
					2	GGAGUAUUUGGAUGACAGA	UCUGUCAUCCAAAUACUCC	Rb	[860-878]
3	AGAGAAUCUCCGCAAGAAA	UUUCUUGCGGAGAUUCUCU		[1109-1127]
					4	GGAUGUUUGGGAGAUGUAA	UUACAUCUCCCAAACAUCC		[1676-1694]
5	GGUCGACCUUAGUACCUAA	UUAGGUACUAAGGUCGACC		[2072-2090]
					6	CCCGGACGAUAUUGAACAA	UUGUUCAAUAUCGUCCGGG		[389-407]
7	GUUAAGGGUUAGUUUACAA	UUGUAAACUAACCCUUAAC		[1709-1727]
					8	GGGUUAAUGAAAUAAUGUA	UACAUUAUUUCAUUAACCC		[1869-1887]
9	AGCUGUCCCUCAUGUUGAA	UUCAACAUGAGGGACAGCU		[1779-1797]
					10	GAAUUUUCUCUAACUUCAA	UUGAAGUUAGAGAAAAUUC		[1795-1813]
11	AUACCAGCUUAGAUUUUAA	UUAAAAUCUAAGCUGGUAU		[1642-1660]
					12	GCAGUUAAGGGUUAGUUUA	UAAACUAACCCUUAACUGC		[1706-1724]
13	AGACCCAGGUCCAGAUGAA	UUCAUCUGGACCUGGGUCU	Mnk	[419-437]
					14	GCAUCUUAUCCGAGUGGAA	UUCCACUCGGAUAAGAUGC	仓鼠	[827-845]
15	AGAUGUUCCGAGAGCUGAA	UUCAGCUCUCGGAACAUCU	大鼠，Rb，猪，Mnk	[1267-1285]
					16	GGGUCAACAUCUUUUACAU	AUGUAAAAGAUGUUGACCC		[2507-2525]
17	GAGGGUUAAUGAAAUAAUG	CAUUAUUUCAUUAACCCUC		[1867-1885]
					18	UGGGUUUUGGGUCUUUGAA	UUCAAAGACCCAAAACCCA		[1498-1516]
19	CUGGAUGGAGAAUAUUUCA	UGAAAUAUUCUCCAUCCAG	Rb，Mnk	[1218-1236]
					20	GUACCACCAUCCACUACAA	UUGUAGUGGAUGGUGGUAC	猪，Mnk	[937-955]
21	GCUGAAUGAGGCCUUGGAA	UUCCAAGGCCUCAUUCAGC	大鼠，Mnk	[1280-1298]
					22	GGGAUGUUUGGGAGAUGUA	UACAUCUCCCAAACAUCCC		[1675-1693]
23	AUAAAAAACUCAUGUUCAA	UUGAACAUGAGUUUUUUAU		[1390-1408]
					24	UGUGAGGGUUAAUGAAAUA	UAUUUCAUUAACCCUCACA		[1864-1882]
25	AAGAGAAUCUCCGCAAGAA	UUCUUGCGGAGAUUCUCUU		[1108-1126]
					26	GAGUAUUUGGAUGACAGAA	UUCUGUCAUCCAAAUACUC	Rb	[861-879]
27	GAAAUGUUCUUGCAGUUAA	UUAACUGCAAGAACAUUUC		[1695-1713]

28	CAUGUUGAAUUUUCUCUAA	UUAGAGAAAAUUCAACAUG		[1789-1807]
					29	GCAUUGUGAGGGUUAAUGA	UCAUUAACCCUCACAAUGC		[1860-1878]
30	GGAAACUACUUCCUGAAAA	UUUUCAGGAAGUAGUUUCC	GP，Mnk	[319-337]
					31	CCAUCAUCACACUGGAAGA	UCUUCCAGUGUGAUGAUGG	Ms，Rb，猪	[1009-1027]
32	AGUGCAUUGUGAGGGUUAA	UUAACCCUCACAAUGCACU		[1857-1875]
					33	GCGUGUGGAGUAUUUGGAU	AUCCAAAUACUCCACACGC		[854-872]
34	GGUGGGUUGGUAGUUUCUA	UAGAAACUACCAACCCACC		[1978-1996]
					35	CUUAGUACCUAAAAGGAAA	UUUCCUUUUAGGUACUAAG		[2079-2097]
36	CAAUAGGUGUGCGUCAGAA	UUCUGACGCACACCUAUUG		[1527-1545]
					37	CAUGAGCGCUGCUCAGAUA	UAUCUGAGCAGCGCUCAUG		[786-804]
38	CCAUCUACAAGCAGUCACA	UGUGACUGCUUGUAGAUGG	Mnk	[733-751]
					39	GUUUGGGAGAUGUAAGAAA	UUUCUUACAUCUCCCAAAC		[1680-1698]
40	GGGAGAUGUAAGAAAUGUU	AACAUUUCUUACAUCUCCC		[1684-1702]
					41	CAGUGGUAAUCUACUGGGA	UCCCAGUAGAUUACCACUG	Mnk	[1031-1049]
42	UGAUCUGGAUCCACCAAGA	UCUUGGUGGAUCCAGAUCA		[2144-2162]
					43	GAAACCACUGGAUGGAGAA	UUCUCCAUCCAGUGGUUUC	Mnk	[1211-1229]
44	GGACAUACCAGCUUAGAUU	AAUCUAAGCUGGUAUGUCC		[1638-1656]
					45	CGAUCUCUUAUUUUACAAU	AUUGUAAAAUAAGAGAUCG		[2596-2614]
46	CCCUCUGAGUCAGGAAACA	UGUUUCCUGACUCAGAGGG	Mnk	[287-305]
					47	GAUCUCUUAUUUUACAAUA	UAUUGUAAAAUAAGAGAUC		[2597-2615]
48	CCAGAUGAAGCUCCCAGAA	UUCUGGGAGCUUCAUCUGG		[429-447]
					49	AGUUAAGGGUUAGUUUACA	UGUAAACUAACCCUUAACU		[1708-1726]
50	CAUCUUUUACAUUCUGCAA	UUGCAGAAUGUAAAAGAUG		[2514-2532]
					51	AACUCAUGUUCAAGACAGA	UCUGUCUUGAACAUGAGUU		[1396-1414]
52	GAAGAGAAUCUCCGCAAGA	UCUUGCGGAGAUUCUCUUC		[1107-1125]
					53	GAGUCAGGAAACAUUUUCA	UGAAAAUGUUUCCUGACUC	Mnk	[293-311]
54	GGAUUUCAUCUCUUGUAUA	UAUACAAGAGAUGAAAUCC		[2122-2140]

55	AGGACAUACCAGCUUAGAU	AUCUAAGCUGGUAUGUCCU		[1637-1655]
					56	CCUUAGUACCUAAAAGGAA	UUCCUUUUAGGUACUAAGG		[2078-2096]
57	CCACCAUCCACUACAACUA	UAGUUGUAGUGGAUGGUGG	GP，犬，Mnk	[940-958]
					58	CAAAGAAGAAACCACUGGA	UCCAGUGGUUUCUUCUUUG	GP，Mnk	[1204-1222]
59	AAGGGUUAGUUUACAAUCA	UGAUUGUAAACUAACCCUU		[1712-1730]
					60	GAGAAUAUUUCACCCUUCA	UGAAGGGUGAAAUAUUCUC	犬，Mnk	[1225-1243]
61	AUAUCGAUCUCUUAUUUUA	UAAAAUAAGAGAUCGAUAU		[2592-2610]
					62	CGACCUUAGUACCUAAAAG	CUUUUAGGUACUAAGGUCG		[2075-2093]
63	UGAGGGUUAAUGAAAUAAU	AUUAUUUCAUUAACCCUCA		[1866-1884]
					64	GGAAGACUCCAGUGGUAAU	AUUACCACUGGAGUCUUCC	Mnk	[1022-1040]
65	GAGGAUUUCAUCUCUUGUA	UACAAGAGAUGAAAUCCUC		[2120-2138]
					66	GAAGGGUCAACAUCUUUUA	UAAAAGAUGUUGACCCUUC		[2504-2522]
67	GGAUGACAGAAACACUUUU	AAAAGUGUUUCUGUCAUCC	猪，Mnk	[869-887]
					68	GCGCACAGAGGAAGAGAAU	AUUCUCUUCCUCUGUGCGC	Mnk	[1097-1115]
69	AAAUGUUCUUGCAGUUAAG	CUUAACUGCAAGAACAUUU		[1696-1714]
					70	CAUAAAAAACUCAUGUUCA	UGAACAUGAGUUUUUUAUG		[1389-1407]
71	CACCAUCAUCACACUGGAA	UUCCAGUGUGAUGAUGGUG	Rb，猪	[1007-1025]
					72	AGGUAGAGGGAGUUGUCAA	UUGACAACUCCCUCUACCU		[2014-2032]
73	UCGAUCUCUUAUUUUACAA	UUGUAAAAUAAGAGAUCGA		[2595-2613]
					74	CUGGAAGACUCCAGUGGUA	UACCACUGGAGUCUUCCAG	Mnk	[1020-1038]
75	UUGUGAGGGUUAAUGAAAU	AUUUCAUUAACCCUCACAA		[1863-1881]
					76	GAAUAUUUCACCCUUCAGA	UCUGAAGGGUGAAAUAUUC	犬，Mnk	[1227-1245]
77	GCUUCGAGAUGUUCCGAGA	UCUCGGAACAUCUCGAAGC	大鼠，猪，Mnk	[1261-1279]
					78	CGUCCCAAGCAAUGGAUGA	UCAUCCAUUGCUUGGGACG		[358-376]
79	CAUUUUCAGACCUAUGGAA	UUCCAUAGGUCUGAAAAUG	Mnk	[304-322]
					80	CCUUGAAACCACCUUUUAU	AUAAAAGGUGGUUUCAAGG		[1895-1913]
81	UGUAUAUGAUGAUCUGGAU	AUCCAGAUCAUCAUAUACA		[2135-2153]

82	GAAACAUUUUCAGACCUAU	AUAGGUCUGAAAAUGUUUC	Mnk	[300-318]
					83	CAAGGCCCAUAUCUGUGAA	UUCACAGAUAUGGGCCUUG		[1811-1829]
84	UGAUGAUCUGGAUCCACCA	UGGUGGAUCCAGAUCAUCA		[2141-2159]
					85	CCACCAAGACUUGUUUUAU	AUAAAACAAGUCUUGGUGG		[2154-2172]
86	GGAAGAGAAUCUCCGCAAG	CUUGCGGAGAUUCUCUUCC		[1106-1124]
					87	GGAAACAUUUUCAGACCUA	UAGGUCUGAAAAUGUUUCC	Mnk	[299-317]
88	GAAAUUUGCGUGUGGAGUA	UACUCCACACGCAAAUUUC	Mnk	[847-865]
					89	ACCACUGGAUGGAGAAUAU	AUAUUCUCCAUCCAGUGGU	Mnk	[1214-1232]
90	UGGGUUGGUAGUUUCUACA	UGUAGAAACUACCAACCCA		[1980-1998]
					91	AUGAGGCCUUGGAACUCAA	UUGAGUUCCAAGGCCUCAU	Mnk	[1285-1303]
92	CAAGCAAUGGAUGAUUUGA	UCAAAUCAUCCAUUGCUUG		[363-381]
					93	CCCUCAUGUUGAAUUUUCU	AGAAAAUUCAACAUGAGGG		[1785-1803]
94	CAGCUUAGAUUUUAAGGUU	AACCUUAAAAUCUAAGCUG		[1646-1664]
					95	CUGGAAGGGUCAACAUCUU	AAGAUGUUGACCCUUCCAG		[2501-2519]
96	GGCAUUUGCACCUACCUCA	UGAGGUAGGUGCAAAUGCC		[1835-1853]
					97	AGUAUUUGGAUGACAGAAA	UUUCUGUCAUCCAAAUACU	Rb	[862-880]
98	AGACUCCAGUGGUAAUCUA	UAGAUUACCACUGGAGUCU	Mnk	[1025-1043]
					99	GGUUGGUAGUUUCUACAGU	ACUGUAGAAACUACCAACC		[1982-2000]
100	GAGGGAGUUGUCAAGUCUU	AAGACUUGACAACUCCCUC		[2019-2037]
					101	AUCGAUCUCUUAUUUUACA	UGUAAAAUAAGAGAUCGAU		[2594-2612]
102	UCACCAUCAUCACACUGGA	UCCAGUGUGAUGAUGGUGA	Rb，猪	[1006-1024]
					103	CACCGUACUAACCAGGGAA	UUCCCUGGUUAGUACGGUG		[1761-1779]
104	GUGGGUUGGUAGUUUCUAC	GUAGAAACUACCAACCCAC		[1979-1997]
					105	CAGACCUAUGGAAACUACU	AGUAGUUUCCAUAGGUCUG	Mnk	[310-328]
106	GCUGUGGGUUGAUUCCACA	UGUGGAAUCAACCCACAGC		[683-701]
					107	GCAAUAGGUGUGCGUCAGA	UCUGACGCACACCUAUUGC		[1526-1544]
108	GGACGAUAUUGAACAAUGG	CCAUUGUUCAAUAUCGUCC		[392-410]

109	CUGACAUUCUCCACUUCUU	AAGAAGUGGAGAAUGUCAG		[1430-1448]
					110	CAGAAAACCUACCAGGGCA	UGCCCUGGUAGGUUUUCUG		[549-567]
111	CAGAAACACUUUUCGACAU	AUGUCGAAAAGUGUUUCUG	Mnk	[875-893]
					112	UGACAGAAACACUUUUCGA	UCGAAAAGUGUUUCUGUCA	猪，Mnk	[872-890]
113	GUGCAUUGUGAGGGUUAAU	AUUAACCCUCACAAUGCAC		[1858-1876]
					114	GAAACCACCUUUUAUUACA	UGUAAUAAAAGGUGGUUUC		[1899-1917]
115	CCUCCUUCUCCCUUUUUAU	AUAAAAAGGGAGAAGGAGG		[2562-2580]
					116	AGUAGGACAUACCAGCUUA	UAAGCUGGUAUGUCCUACU		[1634-1652]
117	GUGAGGGUUAAUGAAAUAA	UUAUUUCAUUAACCCUCAC		[1865-1883]
					118	AAGUUUUGAGCUUCUCAAA	UUUGAGAAGCUCAAAACUU		[97-115]
119	UUGGGUUUUGGGUCUUUGA	UCAAAGACCCAAAACCCAA		[1497-1515]
					120	CAUACCAGCUUAGAUUUUA	UAAAAUCUAAGCUGGUAUG		[1641-1659]
121	AACUACUUCCUGAAAACAA	UUGUUUUCAGGAAGUAGUU	GP	[322-340]
					122	CUGUGAGGGAUGUUUGGGA	UCCCAAACAUCCCUCACAG		[1669-1687]
123	UGAACAAUGGUUCACUGAA	UUCAGUGAACCAUUGUUCA		[401-419]
					124	CCAGGACUUCCAUUUGCUU	AAGCAAAUGGAAGUCCUGG		[1550-1568]
125	GGAGGAUUUCAUCUCUUGU	ACAAGAGAUGAAAUCCUCC		[2119-2137]
					126	GUUGGUAGUUUCUACAGUU	AACUGUAGAAACUACCAAC		[1983-2001]
127	AAGCAAUGGAUGAUUUGAU	AUCAAAUCAUCCAUUGCUU		[364-382]
					128	AUGUUUGGGAGAUGUAAGA	UCUUACAUCUCCCAAACAU		[1678-1696]
129	AGACCUAUGGAAACUACUU	AAGUAGUUUCCAUAGGUCU	Mnk	[311-329]
					130	GAUGAUCUGGAUCCACCAA	UUGGUGGAUCCAGAUCAUC		[2142-2160]
131	AGGAAGAGAAUCUCCGCAA	UUGCGGAGAUUCUCUUCCU		[1105-1123]
					132	CUCACAGAGUGCAUUGUGA	UCACAAUGCACUCUGUGAG		[1850-1868]
133	CCACCUGAAGUCCAAAAAG	CUUUUUGGACUUCAGGUGG		[1352-1370]
					134	GUGGAGUAUUUGGAUGACA	UGUCAUCCAAAUACUCCAC		[858-876]
135	GGAGUAGGACAUACCAGCU	AGCUGGUAUGUCCUACUCC		[1632-1650]

136	CUCUGAGUCAGGAAACAUU	AAUGUUUCCUGACUCAGAG	Mnk	[289-307]
					137	UUAUCCGAGUGGAAGGAAA	UUUCCUUCCACUCGGAUAA	仓鼠，Mnk	[832-850]
138	CACUGGAUGGAGAAUAUUU	AAAUAUUCUCCAUCCAGUG	Mnk	[1216-1234]
					139	UGAGCUUCUCAAAAGUCUA	UAGACUUUUGAGAAGCUCA		[103-121]
140	CAGUUAAGGGUUAGUUUAC	GUAAACUAACCCUUAACUG		[1707-1725]
					141	CCCACUUCACCGUACUAAC	GUUAGUACGGUGAAGUGGG		[1754-1772]
142	GCCCACUUCACCGUACUAA	UUAGUACGGUGAAGUGGGC		[1753-1771]
					143	UGGAAACUACUUCCUGAAA	UUUCAGGAAGUAGUUUCCA	GP，Mnk	[318-336]
144	CAUCCUCACCAUCAUCACA	UGUGAUGAUGGUGAGGAUG	Rb，猪	[1001-1019]
					145	GAGAAUCUCCGCAAGAAAG	CUUUCUUGCGGAGAUUCUC		[1110-1128]
146	CCUGAAGUCCAAAAAGGGU	ACCCUUUUUGGACUUCAGG		[1355-1373]
					147	AUGGAAACUACUUCCUGAA	UUCAGGAAGUAGUUUCCAU	GP，Mnk	[317-335]
148	CAUCUUCUGUCCCUUCCCA	UGGGAAGGGACAGAAGAUG		[532-550]
					149	GUCAGGAAACAUUUUCAGA	UCUGAAAAUGUUUCCUGAC	Mnk	[295-313]
150	AUCCCAUUUUUAUAUCGAU	AUCGAUAUAAAAAUGGGAU		[2581-2599]
					151	CACCAAGACUUGUUUUAUG	CAUAAAACAAGUCUUGGUG		[2155-2173]
152	CGUCUGGGCUUCUUGCAUU	AAUGCAAGAAGCCCAGACG		[579-597]
					153	CUGAGUCAGGAAACAUUUU	AAAAUGUUUCCUGACUCAG	Mnk	[291-309]
154	GAACAAUGGUUCACUGAAG	CUUCAGUGAACCAUUGUUC		[402-420]
					155	ACUCAUGUUCAAGACAGAA	UUCUGUCUUGAACAUGAGU		[1397-1415]
156	AUUGUGAGGGUUAAUGAAA	UUUCAUUAACCCUCACAAU		[1862-1880]
					157	UACCUAAAAGGAAAUCUCA	UGAGAUUUCCUUUUAGGUA		[2084-2102]
158	CGCUAAAAGUUUUGAGCUU	AAGCUCAAAACUUUUAGCG		[91-109]
					159	AGGAUUUCAUCUCUUGUAU	AUACAAGAGAUGAAAUCCU		[2121-2139]
160	CUGACUGUACCACCAUCCA	UGGAUGGUGGUACAGUCAG	仓鼠，Rb，猪，Mnk	[931-949]
					161	GCCUUGAAACCACCUUUUA	UAAAAGGUGGUUUCAAGGC		[1894-1912]
162	AGCUGAAUGAGGCCUUGGA	UCCAAGGCCUCAUUCAGCU	大鼠，Mnk	[1279-1297]

163	GAAACUACUUCCUGAAAAC	GUUUUCAGGAAGUAGUUUC	GP，Mnk	[320-338]
					164	CCAUCCACUACAACUACAU	AUGUAGUUGUAGUGGAUGG	GP，犬，Mnk	[943-961]
165	GAGCUGGAAGGGUCAACAU	AUGUUGACCCUUCCAGCUC		[2498-2516]
					166	UGAAUUUUCUCUAACUUCA	UGAAGUUAGAGAAAAUUCA		[1794-1812]
167	UAUGGAAACUACUUCCUGA	UCAGGAAGUAGUUUCCAUA	GP，Mnk	[316-334]
					168	GAUUUCAUCUCUUGUAUAU	AUAUACAAGAGAUGAAAUC		[2123-2141]
169	UGGAGUAUUUGGAUGACAG	CUGUCAUCCAAAUACUCCA		[859-877]
					170	UUUGGGAGAUGUAAGAAAU	AUUUCUUACAUCUCCCAAA		[1681-1699]
171	AGGGUUAGUUUACAAUCAG	CUGAUUGUAAACUAACCCU		[1713-1731]
					172	CUCAGACUGACAUUCUCCA	UGGAGAAUGUCAGUCUGAG		[1424-1442]
173	GCUUAGAUUUUAAGGUUUU	AAAACCUUAAAAUCUAAGC		[1648-1666]
					174	CCUGCACUGGUGUUUUGUU	AACAAAACACCAGUGCAGG		[1597-1615]
175	CUUUGAGGUGCGUGUUUGU	ACAAACACGCACCUCAAAG	猪	[1058-1076]
					176	UCCUCAGCAUCUUAUCCGA	UCGGAUAAGAUGCUGAGGA	仓鼠	[821-839]
177	UGCAGUUAAGGGUUAGUUU	AAACUAACCCUUAACUGCA		[1705-1723]
					178	AGGCCUUGGAACUCAAGGA	UCCUUGAGUUCCAAGGCCU	Mnk	[1288-1306]
179	AAGCAGUCACAGCACAUGA	UCAUGUGCUGUGACUGCUU	Mnk	[741-759]
					180	AGCUGGUUAGGUAGAGGGA	UCCCUCUACCUAACCAGCU		[2006-2024]
181	GGGUUUUGGGUCUUUGAAC	GUUCAAAGACCCAAAACCC		[1499-1517]
					182	ACAGAAACACUUUUCGACA	UGUCGAAAAGUGUUUCUGU	猪，犬，Mnk	[874-892]
183	GUAAUCUACUGGGACGGAA	UUCCGUCCCAGUAGAUUAC	Mnk	[1036-1054]
					184	GGUAGAGGGAGUUGUCAAG	CUUGACAACUCCCUCUACC		[2015-2033]
185	UUUUUAUAUCGAUCUCUUA	UAAGAGAUCGAUAUAAAAA		[2587-2605]
					186	UGGUGGGUUGGUAGUUUCU	AGAAACUACCAACCCACCA		[1977-1995]
187	CUUUUUAUAUCCCAUUUUU	AAAAAUGGGAUAUAAAAAG		[2573-2591]
					188	CUGCCCUCAACAAGAUGUU	AACAUCUUGUUGAGGGCAG		[634-652]
189	AAAGUUUUGAGCUUCUCAA	UUGAGAAGCUCAAAACUUU		[96-114]

190	GAGGAAGAGAAUCUCCGCA	UGCGGAGAUUCUCUUCCUC		[1104-1122]
					191	GUGAGCGCUUCGAGAUGUU	AACAUCUCGAAGCGCUCAC	大鼠，Mnk	[1255-1273]
192	AAGCACAUCUGCAUUUUCA	UGAAAAUGCAGAUGUGCUU		[2531-2549]
					193	GGAUCCACCAAGACUUGUU	AACAAGUCUUGGUGGAUCC		[2150-2168]
194	CUGACAACCUCUUGGUCGA	UCGACCAAGAGGUUGUCAG		[2059-2077]
					195	UUACAUUCUGCAAGCACAU	AUGUGCUUGCAGAAUGUAA		[2520-2538]
196	UUCUGUCCCUUCCCAGAAA	UUUCUGGGAAGGGACAGAA		[536-554]
					197	CCUGGAGGAUUUCAUCUCU	AGAGAUGAAAUCCUCCAGG		[2116-2134]
198	AAGGAAAUUUGCGUGUGGA	UCCACACGCAAAUUUCCUU	Mnk	[844-862]
					199	AAGAAAUGUUCUUGCAGUU	AACUGCAAGAACAUUUCUU		[1693-1711]
200	GCCUGACUCAGACUGACAU	AUGUCAGUCUGAGUCAGGC		[1418-1436]
					201	CCCAGGACUUCCAUUUGCU	AGCAAAUGGAAGUCCUGGG		[1549-1567]
202	CCACUGGAUGGAGAAUAUU	AAUAUUCUCCAUCCAGUGG	Mnk	[1215-1233]
					203	UCCAAAAAGGGUCAGUCUA	UAGACUGACCCUUUUUGGA		[1362-1380]
204	AACAAUGGUUCACUGAAGA	UCUUCAGUGAACCAUUGUU		[403-421]
					205	AGAUUUUAAGGUUUUUACU	AGUAAAAACCUUAAAAUCU		[1652-1670]
206	UCGACCUUAGUACCUAAAA	UUUUAGGUACUAAGGUCGA		[2074-2092]
					207	CCUCUUGGUCGACCUUAGU	ACUAAGGUCGACCAAGAGG		[2066-2084]
208	ACAUUUUCAGACCUAUGGA	UCCAUAGGUCUGAAAAUGU	Mnk	[303-321]
					209	AGGGUUAAUGAAAUAAUGU	ACAUUAUUUCAUUAACCCU		[1868-1886]
210	UGAAGACCCAGGUCCAGAU	AUCUGGACCUGGGUCUUCA	Mnk	[416-434]
					211	UGCGUGUGGAGUAUUUGGA	UCCAAAUACUCCACACGCA		[853-871]
212	CCCUGUCUGACAACCUCUU	AAGAGGUUGUCAGACAGGG		[2053-2071]
					213	GAUGUUUGGGAGAUGUAAG	CUUACAUCUCCCAAACAUC		[1677-1695]
214	GGCCCAUAUCUGUGAAAUG	CAUUUCACAGAUAUGGGCC		[1814-1832]
					215	GUGUGGAGUAUUUGGAUGA	UCAUCCAAAUACUCCACAC		[856-874]
216	AGGUUUUUACUGUGAGGGA	UCCCUCACAGUAAAAACCU		[1660-1678]

217	GCUGGUGGGUUGGUAGUUU	AAACUACCAACCCACCAGC		[1975-1993]
					218	AAACCACCUUUUAUUACAU	AUGUAAUAAAAGGUGGUUU		[1900-1918]
219	GGAGUUGUCAAGUCUUGCU	AGCAAGACUUGACAACUCC		[2022-2040]
					220	CCCUCAACAAGAUGUUUUG	CAAAACAUCUUGUUGAGGG		[637-655]
221	ACAUCUUUUACAUUCUGCA	UGCAGAAUGUAAAAGAUGU		[2513-2531]
					222	CCCUCCUUCUCCCUUUUUA	UAAAAAGGGAGAAGGAGGG		[2561-2579]
223	CCCAUAUCUGUGAAAUGCU	AGCAUUUCACAGAUAUGGG		[1816-1834]
					224	AAUAUUUCACCCUUCAGAU	AUCUGAAGGGUGAAAUAUU	犬，Mnk	[1228-1246]
225	CCAUAUCUGUGAAAUGCUG	CAGCAUUUCACAGAUAUGG		[1817-1835]
					226	AUGGUUCACUGAAGACCCA	UGGGUCUUCAGUGAACCAU		[407-425]
227	UUGGGCAGCUGGUUAGGUA	UACCUAACCAGCUGCCCAA		[2000-2018]
					228	GAUAUUGAACAAUGGUUCA	UGAACCAUUGUUCAAUAUC		[396-414]
229	UCCCUUCCCAGAAAACCUA	UAGGUUUUCUGGGAAGGGA	Mnk	[541-559]
					230	CUUCUGUCCCUUCCCAGAA	UUCUGGGAAGGGACAGAAG		[535-553]
231	CUUAGAUUUUAAGGUUUUU	AAAAACCUUAAAAUCUAAG		[1649-1667]
					232	CUAACUUCAAGGCCCAUAU	AUAUGGGCCUUGAAGUUAG		[1804-1822]
233	GUCCCUUCCCAGAAAACCU	AGGUUUUCUGGGAAGGGAC	Mnk	[540-558]
					234	AGUUUUGAGCUUCUCAAAA	UUUUGAGAAGCUCAAAACU		[98-116]
235	AGAUGUAAGAAAUGUUCUU	AAGAACAUUUCUUACAUCU		[1687-1705]
					236	UCUGUCCCUUCCCAGAAAA	UUUUCUGGGAAGGGACAGA	Mnk	[537-555]
237	UUUACAUUCUGCAAGCACA	UGUGCUUGCAGAAUGUAAA		[2519-2537]
					238	GAGUGCAUUGUGAGGGUUA	UAACCCUCACAAUGCACUC		[1856-1874]
239	GGGCUCCACUGAACAAGUU	AACUUGUUCAGUGGAGCCC		[1576-1594]
					240	GGAAGCUGUCCCUCAUGUU	AACAUGAGGGACAGCUUCC		[1776-1794]
241	AGAAACACUUUUCGACAUA	UAUGUCGAAAAGUGUUUCU	Mnk	[876-894]
					242	GGGUUGGUAGUUUCUACAG	CUGUAGAAACUACCAACCC		[1981-1999]
243	CCGAGUGGAAGGAAAUUUG	CAAAUUUCCUUCCACUCGG	犬，Mnk	[836-854]

244	CCCAAGCAAUGGAUGAUUU	AAAUCAUCCAUUGCUUGGG		[361-379]
					245	GCUGGAAGGGUCAACAUCU	AGAUGUUGACCCUUCCAGC		[2500-2518]
246	UGUUUGGGAGAUGUAAGAA	UUCUUACAUCUCCCAAACA		[1679-1697]
					247	CAGAGUGCAUUGUGAGGGU	ACCCUCACAAUGCACUCUG		[1854-1872]
248	GAAGAAACCACUGGAUGGA	UCCAUCCAGUGGUUUCUUC	Mnk	[1208-1226]
					249	GGCCUUGGAACUCAAGGAU	AUCCUUGAGUUCCAAGGCC	Mnk	[1289-1307]
250	GUCGACCUUAGUACCUAAA	UUUAGGUACUAAGGUCGAC		[2073-2091]
					251	GGUUUUUACUGUGAGGGAU	AUCCCUCACAGUAAAAACC		[1661-1679]
252	GAUCCACCAAGACUUGUUU	AAACAAGUCUUGGUGGAUC		[2151-2169]
					253	ACUACUUCCUGAAAACAAC	GUUGUUUUCAGGAAGUAGU	GP	[323-341]
254	UCAUGUUGAAUUUUCUCUA	UAGAGAAAAUUCAACAUGA		[1788-1806]
					255	CCAAGACUUGUUUUAUGCU	AGCAUAAAACAAGUCUUGG		[2157-2175]
256	CAUUUGCACCUACCUCACA	UGUGAGGUAGGUGCAAAUG		[1837-1855]
					257	GGUAGUUUCUACAGUUGGG	CCCAACUGUAGAAACUACC		[1986-2004]
258	GACUCAGACUGACAUUCUC	GAGAAUGUCAGUCUGAGUC		[1422-1440]
					259	GUAUUUGGAUGACAGAAAC	GUUUCUGUCAUCCAAAUAC	Rb	[863-881]
260	AGAGGGAGUUGUCAAGUCU	AGACUUGACAACUCCCUCU		[2018-2036]
					261	AGAAACCACUGGAUGGAGA	UCUCCAUCCAGUGGUUUCU	Mnk	[1210-1228]
262	AAAGAAGAAACCACUGGAU	AUCCAGUGGUUUCUUCUUU	GP，Mnk	[1205-1223]
					263	GUAGGACAUACCAGCUUAG	CUAAGCUGGUAUGUCCUAC		[1635-1653]
264	AGUCACAGCACAUGACGGA	UCCGUCAUGUGCUGUGACU	Ms，GP，Mnk	[745-763]
					265	CGAGUGGAAGGAAAUUUGC	GCAAAUUUCCUUCCACUCG	犬，Mnk	[837-855]
266	UCUGGAUCCACCAAGACUU	AAGUCUUGGUGGAUCCAGA		[2147-2165]
					267	GGCCUUGAAACCACCUUUU	AAAAGGUGGUUUCAAGGCC		[1893-1911]
268	GGGUUAGUUUACAAUCAGC	GCUGAUUGUAAACUAACCC		[1714-1732]
					269	GACAUACCAGCUUAGAUUU	AAAUCUAAGCUGGUAUGUC		[1639-1657]
270	CACCUGAAGUCCAAAAAGG	CCUUUUUGGACUUCAGGUG		[1353-1371]

271	UGUUGAAUUUUCUCUAACU	AGUUAGAGAAAAUUCAACA		[1791-1809]
					272	CUGGUUAGGUAGAGGGAGU	ACUCCCUCUACCUAACCAG		[2008-2026]
273	CCAGCUUAGAUUUUAAGGU	ACCUUAAAAUCUAAGCUGG		[1645-1663]
					274	GGUCAACAUCUUUUACAUU	AAUGUAAAAGAUGUUGACC		[2508-2526]
275	AGCACAUGACGGAGGUUGU	ACAACCUCCGUCAUGUGCU		[751-769]
					276	CCUCUGAGUCAGGAAACAU	AUGUUUCCUGACUCAGAGG	Mnk	[288-306]
277	CCAUCCUCACCAUCAUCAC	GUGAUGAUGGUGAGGAUGG	Rb，猪，GP	[1000-1018]
					278	CUCCCUUUUUAUAUCCCAU	AUGGGAUAUAAAAAGGGAG		[2569-2587]
279	CUUGAAACCACCUUUUAUU	AAUAAAAGGUGGUUUCAAG		[1896-1914]
					280	UCUGCAAGCACAUCUGCAU	AUGCAGAUGUGCUUGCAGA		[2526-2544]
281	CUCCUUCUCCCUUUUUAUA	UAUAAAAAGGGAGAAGGAG		[2563-2581]
					282	ACUGUACCACCAUCCACUA	UAGUGGAUGGUGGUACAGU	仓鼠，Rb，猪，Mnk	[934-952]
283	UAGGACAUACCAGCUUAGA	UCUAAGCUGGUAUGUCCUA		[1636-1654]
					284	AUAUGAUGAUCUGGAUCCA	UGGAUCCAGAUCAUCAUAU		[2138-2156]
285	CCUGACUCAGACUGACAUU	AAUGUCAGUCUGAGUCAGG		[1419-1437]
					286	CAGCUUUGAGGUGCGUGUU	AACACGCACCUCAAAGCUG	猪	[1055-1073]
287	GUCCAAAAAGGGUCAGUCU	AGACUGACCCUUUUUGGAC		[1361-1379]
					288	ACACCCUGGAGGAUUUCAU	AUGAAAUCCUCCAGGGUGU		[2112-2130]
289	GUGAGGGAUGUUUGGGAGA	UCUCCCAAACAUCCCUCAC		[1671-1689]
					290	ACCUUAGUACCUAAAAGGA	UCCUUUUAGGUACUAAGGU		[2077-2095]
291	UGUGCAGCUGUGGGUUGAU	AUCAACCCACAGCUGCACA		[677-695]
					292	CGGACGAUAUUGAACAAUG	CAUUGUUCAAUAUCGUCCG		[391-409]
293	CAUCUCUUGUAUAUGAUGA	UCAUCAUAUACAAGAGAUG		[2128-2146]
					294	GUUGAAUUUUCUCUAACUU	AAGUUAGAGAAAAUUCAAC		[1792-1810]
295	UAUCCGAGUGGAAGGAAAU	AUUUCCUUCCACUCGGAUA	仓鼠，Mnk	[833-851]
					296	UGUAAGAAAUGUUCUUGCA	UGCAAGAACAUUUCUUACA		[1690-1708]
297	CUGCAAGCACAUCUGCAUU	AAUGCAGAUGUGCUUGCAG		[2527-2545]

298	CUGGAGGAUUUCAUCUCUU	AAGAGAUGAAAUCCUCCAG		[2117-2135]
					299	UUUCAUCUCUUGUAUAUGA	UCAUAUACAAGAGAUGAAA		[2125-2143]
300	AAAUUUGCGUGUGGAGUAU	AUACUCCACACGCAAAUUU	Mnk	[848-866]
					301	GCACAGAGGAAGAGAAUCU	AGAUUCUCUUCCUCUGUGC		[1099-1117]
302	CUUCCCAGAAAACCUACCA	UGGUAGGUUUUCUGGGAAG	Mnk	[544-562]
					303	AAGACAGAAGGGCCUGACU	AGUCAGGCCCUUCUGUCUU		[1407-1425]
304	GACGAUAUUGAACAAUGGU	ACCAUUGUUCAAUAUCGUC		[393-411]
					305	GGUAAUCUACUGGGACGGA	UCCGUCCCAGUAGAUUACC	Mnk	[1035-1053]
306	AAUCUACUGGGACGGAACA	UGUUCCGUCCCAGUAGAUU	Mnk	[1038-1056]
					307	CUUUUACAUUCUGCAAGCA	UGCUUGCAGAAUGUAAAAG		[2517-2535]
308	GUUAAUGAAAUAAUGUACA	UGUACAUUAUUUCAUUAAC		[1871-1889]
					309	UCUGAGUCAGGAAACAUUU	AAAUGUUUCCUGACUCAGA	Mnk	[290-308]
310	AUAGUGUGGUGGUGCCCUA	UAGGGCACCACCACACUAU	Mnk	[892-910]
					311	UCUCUAACUUCAAGGCCCA	UGGGCCUUGAAGUUAGAGA		[1801-1819]
312	AAGGCCCAUAUCUGUGAAA	UUUCACAGAUAUGGGCCUU		[1812-1830]
					313	UAUCGAUCUCUUAUUUUAC	GUAAAAUAAGAGAUCGAUA		[2593-2611]
314	CCCUUUUUAUAUCCCAUUU	AAAUGGGAUAUAAAAAGGG		[2571-2589]
					315	GGAGAAUAUUUCACCCUUC	GAAGGGUGAAAUAUUCUCC	犬，Mnk	[1224-1242]
316	CAGCUGUGGGUUGAUUCCA	UGGAAUCAACCCACAGCUG		[681-699]
					317	CCAAAAAGGGUCAGUCUAC	GUAGACUGACCCUUUUUGG		[1363-1381]
318	GGAAGGGUCAACAUCUUUU	AAAAGAUGUUGACCCUUCC		[2503-2521]
					319	CACCCUGGAGGAUUUCAUC	GAUGAAAUCCUCCAGGGUG		[2113-2131]
320	CCACAUUCUAGGUAGGUAG	CUACCUACCUAGAAUGUGG		[1732-1750]
					321	UCCAGAUGAAGCUCCCAGA	UCUGGGAGCUUCAUCUGGA		[428-446]
322	UGGUCGACCUUAGUACCUA	UAGGUACUAAGGUCGACCA		[2071-2089]
					323	AAAAAACUCAUGUUCAAGA	UCUUGAACAUGAGUUUUUU		[1392-1410]
324	CACUUCACCGUACUAACCA	UGGUUAGUACGGUGAAGUG		[1756-1774]

325	UGGAGAAUAUUUCACCCUU	AAGGGUGAAAUAUUCUCCA	大鼠，犬，Mnk	[1223-1241]
					326	GAGUAGGACAUACCAGCUU	AAGCUGGUAUGUCCUACUC		[1633-1651]
327	CCUACCUCACAGAGUGCAU	AUGCACUCUGUGAGGUAGG		[1845-1863]
					328	AGGGUCAACAUCUUUUACA	UGUAAAAGAUGUUGACCCU		[2506-2524]
329	CAUUCUGCAAGCACAUCUG	CAGAUGUGCUUGCAGAAUG		[2523-2541]
					330	CUGUCAUCUUCUGUCCCUU	AAGGGACAGAAGAUGACAG		[528-546]
331	ACAGUUGGGCAGCUGGUUA	UAACCAGCUGCCCAACUGU		[1996-2014]
					332	GGUUAAUGAAAUAAUGUAC	GUACAUUAUUUCAUUAACC		[1870-1888]
333	GGACUUCCAUUUGCUUUGU	ACAAAGCAAAUGGAAGUCC		[1553-1571]
					334	AAACACUUUUCGACAUAGU	ACUAUGUCGAAAAGUGUUU	Mnk	[878-896]
335	ACCCUUGCUUGCAAUAGGU	ACCUAUUGCAAGCAAGGGU		[1516-1534]
					336	UUUGGAUGACAGAAACACU	AGUGUUUCUGUCAUCCAAA		[866-884]
337	CAACAUCUUUUACAUUCUG	CAGAAUGUAAAAGAUGUUG		[2511-2529]
					338	AGCUUAGAUUUUAAGGUUU	AAACCUUAAAAUCUAAGCU		[1647-1665]
339	CUCUUGGUCGACCUUAGUA	UACUAAGGUCGACCAAGAG		[2067-2085]
					340	UAUUUGGAUGACAGAAACA	UGUUUCUGUCAUCCAAAUA	Rb	[864-882]
341	AAACCUACCAGGGCAGCUA	UAGCUGCCCUGGUAGGUUU		[553-571]
					342	CAACAACACCAGCUCCUCU	AGAGGAGCUGGUGUUGUUG	Mnk	[1178-1196]
343	CCCUCCUCAGCAUCUUAUC	GAUAAGAUGCUGAGGAGGG		[818-836]
					344	UCACCGUACUAACCAGGGA	UCCCUGGUUAGUACGGUGA		[1760-1778]
345	GACGGAACAGCUUUGAGGU	ACCUCAAAGCUGUUCCGUC	仓鼠，Rb，猪，Mnk	[1048-1066]
					346	AGGGAGUUGUCAAGUCUUG	CAAGACUUGACAACUCCCU		[2020-2038]
347	GAGAUGUUCCGAGAGCUGA	UCAGCUCUCGGAACAUCUC	大鼠，Rb，猪，Mnk	[1266-1284]
					348	CUGGAUCCACCAAGACUUG	CAAGUCUUGGUGGAUCCAG		[2148-2166]
349	CUGGUGGGUUGGUAGUUUC	GAAACUACCAACCCACCAG		[1976-1994]
					350	GGGUCUUUGAACCCUUGCU	AGCAAGGGUUCAAAGACCC		[1506-1524]
351	UCUUCUGUCCCUUCCCAGA	UCUGGGAAGGGACAGAAGA		[534-552]

352	CCAAGUCUGUGACUUGCAC	GUGCAAGUCACAGACUUGG	Mnk	[607-625]
					353	GUCCCAAGCAAUGGAUGAU	AUCAUCCAUUGCUUGGGAC		[359-377]
354	UCUACAAGCAGUCACAGCA	UGCUGUGACUGCUUGUAGA	Mnk	[736-754]
					355	CUUCAAGGCCCAUAUCUGU	ACAGAUAUGGGCCUUGAAG		[1808-1826]
356	UUGAAACCACCUUUUAUUA	UAAUAAAAGGUGGUUUCAA		[1897-1915]
					357	UCAGAAGCACCCAGGACUU	AAGUCCUGGGUGCUUCUGA		[1540-1558]
358	CCAAGCAAUGGAUGAUUUG	CAAAUCAUCCAUUGCUUGG		[362-380]
					359	GCAUUUGCACCUACCUCAC	GUGAGGUAGGUGCAAAUGC		[1836-1854]
360	UAGGUGUGCGUCAGAAGCA	UGCUUCUGACGCACACCUA		[1530-1548]
					361	ACCUGAAGUCCAAAAAGGG	CCCUUUUUGGACUUCAGGU		[1354-1372]
362	UGGAAGACUCCAGUGGUAA	UUACCACUGGAGUCUUCCA	Mnk	[1021-1039]
					363	UGGGACGGAACAGCUUUGA	UCAAAGCUGUUCCGUCCCA	仓鼠，Rb，猪，Mnk	[1045-1063]
364	UUGUAUAUGAUGAUCUGGA	UCCAGAUCAUCAUAUACAA		[2134-2152]
					365	GACUGUACCACCAUCCACU	AGUGGAUGGUGGUACAGUC	仓鼠，Rb，猪，Mnk	[933-951]
366	GGAGAUGUAAGAAAUGUUC	GAACAUUUCUUACAUCUCC		[1685-1703]
					367	GAAGGAAAUUUGCGUGUGG	CCACACGCAAAUUUCCUUC	Mnk	[843-861]
368	UCAACAUCUUUUACAUUCU	AGAAUGUAAAAGAUGUUGA		[2510-2528]
					369	AGACUGACAUUCUCCACUU	AAGUGGAGAAUGUCAGUCU		[1427-1445]
370	UGUUCCGAGAGCUGAAUGA	UCAUUCAGCUCUCGGAACA	大鼠，猪，Mnk	[1270-1288]
					371	UUUGAACCCUUGCUUGCAA	UUGCAAGCAAGGGUUCAAA		[1511-1529]
372	GAGAUGUAAGAAAUGUUCU	AGAACAUUUCUUACAUCUC		[1686-1704]
					373	UAAGAAAUGUUCUUGCAGU	ACUGCAAGAACAUUUCUUA		[1692-1710]
374	AGCACAUCUGCAUUUUCAC	GUGAAAAUGCAGAUGUGCU		[2532-2550]
					375	UUGGAUGACAGAAACACUU	AAGUGUUUCUGUCAUCCAA	猪	[867-885]
376	CCUUUUUAUAUCCCAUUUU	AAAAUGGGAUAUAAAAAGG		[2572-2590]
					377	UGGAUGACAGAAACACUUU	AAAGUGUUUCUGUCAUCCA	猪	[868-886]
378	GUGCAGCUGUGGGUUGAUU	AAUCAACCCACAGCUGCAC		[678-696]

379	AAGCUGUCCCUCAUGUUGA	UCAACAUGAGGGACAGCUU		[1778-1796]
					380	CAGAUGAAGCUCCCAGAAU	AUUCUGGGAGCUUCAUCUG		[430-448]
381	UGAAGUCCAAAAAGGGUCA	UGACCCUUUUUGGACUUCA		[1357-1375]
					382	AGGAAAUUUGCGUGUGGAG	CUCCACACGCAAAUUUCCU	Mnk	[845-863]
383	UGGGAGAUGUAAGAAAUGU	ACAUUUCUUACAUCUCCCA		[1683-1701]
					384	UCUUGUAUAUGAUGAUCUG	CAGAUCAUCAUAUACAAGA		[2132-2150]
385	GACAGAAACACUUUUCGAC	GUCGAAAAGUGUUUCUGUC	猪，犬，Mnk	[873-891]
					386	ACAAGCAGUCACAGCACAU	AUGUGCUGUGACUGCUUGU	Mnk	[739-757]
387	CUCCAGUGGUAAUCUACUG	CAGUAGAUUACCACUGGAG	Mnk	[1028-1046]
					388	CGUGUGGAGUAUUUGGAUG	CAUCCAAAUACUCCACACG		[855-873]
389	GAGGGAUGUUUGGGAGAUG	CAUCUCCCAAACAUCCCUC		[1673-1691]
					390	GGAAAUUUGCGUGUGGAGU	ACUCCACACGCAAAUUUCC	Mnk	[846-864]
391	AGGGAUGUUUGGGAGAUGU	ACAUCUCCCAAACAUCCCU		[1674-1692]
					392	AAACUACUUCCUGAAAACA	UGUUUUCAGGAAGUAGUUU	GP	[321-339]
393	CUCAGAUAGCGAUGGUCUG	CAGACCAUCGCUAUCUGAG		[797-815]
					394	AUCUCUUGUAUAUGAUGAU	AUCAUCAUAUACAAGAGAU		[2129-2147]
395	AGCAAUGGAUGAUUUGAUG	CAUCAAAUCAUCCAUUGCU		[365-383]
					396	ACCAUCCACUACAACUACA	UGUAGUUGUAGUGGAUGGU	GP，犬，Mnk	[942-960]
397	AGUGGAAGGAAAUUUGCGU	ACGCAAAUUUCCUUCCACU	Mnk	[839-857]
					398	GGUCUUUGAACCCUUGCUU	AAGCAAGGGUUCAAAGACC		[1507-1525]
399	CCCAUCCUCACCAUCAUCA	UGAUGAUGGUGAGGAUGGG	Rb，猪，GP	[999-1017]
					400	GAGUGGAAGGAAAUUUGCG	CGCAAAUUUCCUUCCACUC	犬，Mnk	[838-856]
401	CUUCUUGCAUUCUGGGACA	UGUCCCAGAAUGCAAGAAG		[587-605]
					402	UUGCAAUAGGUGUGCGUCA	UGACGCACACCUAUUGCAA		[1524-1542]
403	AGGCCCAUAUCUGUGAAAU	AUUUCACAGAUAUGGGCCU		[1813-1831]
					404	CUACAAGCAGUCACAGCAC	GUGCUGUGACUGCUUGUAG	Mnk	[737-755]
405	UCCACCAAGACUUGUUUUA	UAAAACAAGUCUUGGUGGA		[2153-2171]

406	GAUGUUCCGAGAGCUGAAU	AUUCAGCUCUCGGAACAUC	大鼠，猪，Mnk	[1268-1286]
					407	AAGCACCCAGGACUUCCAU	AUGGAAGUCCUGGGUGCUU		[1544-1562]
408	AGCUUUGAGGUGCGUGUUU	AAACACGCACCUCAAAGCU	猪	[1056-1074]
					409	AUUUUUAUAUCGAUCUCUU	AAGAGAUCGAUAUAAAAAU		[2586-2604]
410	CCAUUUUUAUAUCGAUCUC	GAGAUCGAUAUAAAAAUGG		[2584-2602]
					411	GCACUGGUGUUUUGUUGUG	CACAACAAAACACCAGUGC		[1600-1618]
412	CACAUGACGGAGGUUGUGA	UCACAACCUCCGUCAUGUG		[753-771]
					413	CGUACUAACCAGGGAAGCU	AGCUUCCCUGGUUAGUACG		[1764-1782]
414	ACAGCUUUGAGGUGCGUGU	ACACGCACCUCAAAGCUGU	猪	[1054-1072]
					415	UCCUCACCAUCAUCACACU	AGUGUGAUGAUGGUGAGGA	Rb，猪	[1003-1021]
416	ACUCCAGUGGUAAUCUACU	AGUAGAUUACCACUGGAGU	Mnk	[1027-1045]
					417	GGGAGUUGUCAAGUCUUGC	GCAAGACUUGACAACUCCC		[2021-2039]
418	AUUUGCGUGUGGAGUAUUU	AAAUACUCCACACGCAAAU		[850-868]
					419	AGAAAUGUUCUUGCAGUUA	UAACUGCAAGAACAUUUCU		[1694-1712]
420	CUGCUCAGAUAGCGAUGGU	ACCAUCGCUAUCUGAGCAG		[794-812]
					421	CAUUUUGGGUUUUGGGUCU	AGACCCAAAACCCAAAAUG		[1493-1511]
422	ACCUCUUGGUCGACCUUAG	CUAAGGUCGACCAAGAGGU		[2065-2083]
					423	UAUCCCAUUUUUAUAUCGA	UCGAUAUAAAAAUGGGAUA		[2580-2598]
424	UACUGGGACGGAACAGCUU	AAGCUGUUCCGUCCCAGUA	Mnk	[1042-1060]
					425	UUAAGGGUUAGUUUACAAU	AUUGUAAACUAACCCUUAA		[1710-1728]
426	GCCCUCAACAAGAUGUUUU	AAAACAUCUUGUUGAGGGC		[636-654]
					427	ACUGGAUGGAGAAUAUUUC	GAAAUAUUCUCCAUCCAGU	Mnk	[1217-1235]
428	AGCUGUGGGUUGAUUCCAC	GUGGAAUCAACCCACAGCU		[682-700]
					429	UGUCCCUCAUGUUGAAUUU	AAAUUCAACAUGAGGGACA		[1782-1800]
430	AGUCAGGAAACAUUUUCAG	CUGAAAAUGUUUCCUGACU	Mnk	[294-312]
					431	CACACCCUGGAGGAUUUCA	UGAAAUCCUCCAGGGUGUG		[2111-2129]
432	GAUGGAGAAUAUUUCACCC	GGGUGAAAUAUUCUCCAUC	大鼠，犬，Mnk	[1221-1239]

433	ACAUGACGGAGGUUGUGAG	CUCACAACCUCCGUCAUGU		[754-772]
					434	AGAAUAUUUCACCCUUCAG	CUGAAGGGUGAAAUAUUCU	犬，Mnk	[1226-1244]
435	UACAAGCAGUCACAGCACA	UGUGCUGUGACUGCUUGUA	Mnk	[738-756]
					436	GCGCUAAAAGUUUUGAGCU	AGCUCAAAACUUUUAGCGC	GP	[90-108]
437	GCACCCAGGACUUCCAUUU	AAAUGGAAGUCCUGGGUGC		[1546-1564]
					438	UGACACGCUUCCCUGGAUU	AAUCCAGGGAAGCGUGUCA		[203-221]
439	GUCUGUGACUUGCACGUAC	GUACGUGCAAGUCACAGAC	Mnk	[611-629]
					440	UAGGUAGAGGGAGUUGUCA	UGACAACUCCCUCUACCUA		[2013-2031]
441	CACCAUCCACUACAACUAC	GUAGUUGUAGUGGAUGGUG	GP，犬，Mnk	[941-959]
					442	GACAUUCUCCACUUCUUGU	ACAAGAAGUGGAGAAUGUC		[1432-1450]
443	UUAUAUCGAUCUCUUAUUU	AAAUAAGAGAUCGAUAUAA		[2590-2608]
					444	UGAGGGAUGUUUGGGAGAU	AUCUCCCAAACAUCCCUCA		[1672-1690]
445	CCUGCCCUCAACAAGAUGU	ACAUCUUGUUGAGGGCAGG		[633-651]
					446	AAAAGUUUUGAGCUUCUCA	UGAGAAGCUCAAAACUUUU		[95-113]
447	UUUGCACCUACCUCACAGA	UCUGUGAGGUAGGUGCAAA		[1839-1857]
					448	AAAACUCAUGUUCAAGACA	UGUCUUGAACAUGAGUUUU		[1394-1412]
449	UGCCCUCAACAAGAUGUUU	AAACAUCUUGUUGAGGGCA		[635-653]
					450	CUUGCAGUUAAGGGUUAGU	ACUAACCCUUAACUGCAAG		[1703-1721]
451	AGAUGAAGCUCCCAGAAUG	CAUUCUGGGAGCUUCAUCU		[431-449]
					452	AAUAGGUGUGCGUCAGAAG	CUUCUGACGCACACCUAUU		[1528-1546]
453	AUUUUCAGACCUAUGGAAA	UUUCCAUAGGUCUGAAAAU	Mnk	[305-323]
					454	ACACUUUUCGACAUAGUGU	ACACUAUGUCGAAAAGUGU	Mnk	[880-898]
455	GCCUGCACUGGUGUUUUGU	ACAAAACACCAGUGCAGGC		[1596-1614]
					456	UUCUGCAAGCACAUCUGCA	UGCAGAUGUGCUUGCAGAA		[2525-2543]
457	GCUCAGAUAGCGAUGGUCU	AGACCAUCGCUAUCUGAGC		[796-814]
					458	GAAACACUUUUCGACAUAG	CUAUGUCGAAAAGUGUUUC	Mnk	[877-895]
459	CAUCCACUACAACUACAUG	CAUGUAGUUGUAGUGGAUG	GP，犬，Mnk	[944-962]

460	ACUGGGACGGAACAGCUUU	AAAGCUGUUCCGUCCCAGU	Mnk	[1043-1061]
					461	UUUUAUAUCGAUCUCUUAU	AUAAGAGAUCGAUAUAAAA		[2588-2606]
462	GUACCUAAAAGGAAAUCUC	GAGAUUUCCUUUUAGGUAC		[2083-2101]
					463	UUCAUCUCUUGUAUAUGAU	AUCAUAUACAAGAGAUGAA		[2126-2144]
464	GGAUGGAGAAUAUUUCACC	GGUGAAAUAUUCUCCAUCC	Mnk	[1220-1238]
					465	GGCUUCUUGCAUUCUGGGA	UCCCAGAAUGCAAGAAGCC		[585-603]
466	CAGAGGAAGAGAAUCUCCG	CGGAGAUUCUCUUCCUCUG		[1102-1120]
					467	CUAAAAGUUUUGAGCUUCU	AGAAGCUCAAAACUUUUAG		[93-111]
468	GAUCUGGAUCCACCAAGAC	GUCUUGGUGGAUCCAGAUC		[2145-2163]
					469	CAAUGGAUGAUUUGAUGCU	AGCAUCAAAUCAUCCAUUG		[367-385]
470	UGUGGAGUAUUUGGAUGAC	GUCAUCCAAAUACUCCACA		[857-875]
					471	GCUCUGACUGUACCACCAU	AUGGUGGUACAGUCAGAGC	仓鼠，Rb，猪，Mnk	[928-946]
472	UGAACCCUUGCUUGCAAUA	UAUUGCAAGCAAGGGUUCA		[1513-1531]
					473	GCAAGCACAUCUGCAUUUU	AAAAUGCAGAUGUGCUUGC		[2529-2547]
474	CAGGACUUCCAUUUGCUUU	AAAGCAAAUGGAAGUCCUG		[1551-1569]
					475	CCUGUCAUCUUCUGUCCCU	AGGGACAGAAGAUGACAGG		[527-545]
476	UCAUGUUCAAGACAGAAGG	CCUUCUGUCUUGAACAUGA		[1399-1417]
					477	GUUUCCGUCUGGGCUUCUU	AAGAAGCCCAGACGGAAAC		[574-592]
478	AAACAUUUUCAGACCUAUG	CAUAGGUCUGAAAAUGUUU	Mnk	[301-319]
					479	UUAGUACCUAAAAGGAAAU	AUUUCCUUUUAGGUACUAA		[2080-2098]
480	CCCAUUUUUAUAUCGAUCU	AGAUCGAUAUAAAAAUGGG		[2583-2601]
					481	CACACUGGAAGACUCCAGU	ACUGGAGUCUUCCAGUGUG	Ms，Rb，Mnk	[1016-1034]
482	CUCUAACUUCAAGGCCCAU	AUGGGCCUUGAAGUUAGAG		[1802-1820]
					483	GUUCAAGACAGAAGGGCCU	AGGCCCUUCUGUCUUGAAC		[1403-1421]
484	CAACCUCUUGGUCGACCUU	AAGGUCGACCAAGAGGUUG		[2063-2081]
					485	AGCAGUCACAGCACAUGAC	GUCAUGUGCUGUGACUGCU	Mnk	[742-760]
486	CUCAGCAUCUUAUCCGAGU	ACUCGGAUAAGAUGCUGAG	仓鼠	[823-841]

487	ACUUCACCGUACUAACCAG	CUGGUUAGUACGGUGAAGU		[1757-1775]
					488	UCUCCCUUUUUAUAUCCCA	UGGGAUAUAAAAAGGGAGA		[2568-2586]
489	GACUCCAGUGGUAAUCUAC	GUAGAUUACCACUGGAGUC	Mnk	[1026-1044]
					490	ACAUACCAGCUUAGAUUUU	AAAAUCUAAGCUGGUAUGU		[1640-1658]
491	GUAAGAAAUGUUCUUGCAG	CUGCAAGAACAUUUCUUAC		[1691-1709]
					492	UCAAGACAGAAGGGCCUGA	UCAGGCCCUUCUGUCUUGA		[1405-1423]
493	AAGACCCAGGUCCAGAUGA	UCAUCUGGACCUGGGUCUU	Mnk	[418-436]
					494	CUUUGAACCCUUGCUUGCA	UGCAAGCAAGGGUUCAAAG		[1510-1528]
495	CAGGAAACAUUUUCAGACC	GGUCUGAAAAUGUUUCCUG	Mnk	[297-315]
					496	CUGUCCCUUCCCAGAAAAC	GUUUUCUGGGAAGGGACAG	Mnk	[538-556]
497	CCAUAAAAAACUCAUGUUC	GAACAUGAGUUUUUUAUGG		[1388-1406]
					498	AUGAAAUAAUGUACAUCUG	CAGAUGUACAUUAUUUCAU		[1875-1893]
499	UGGAAGGGUCAACAUCUUU	AAAGAUGUUGACCCUUCCA		[2502-2520]
					500	CGCACAGAGGAAGAGAAUC	GAUUCUCUUCCUCUGUGCG		[1098-1116]

表B 25PARP1-聚(ADP-核糖)聚合酶1

No.	正义链siRNA	反义链siRNA	其他Sp	人-156523967：172-3216
					1	GGAGGAAGGUAUCAACAAA	UUUGUUGAUACCUUCCUCC	Chmp	[1707-1725]
2	GGCGAAGAAGAAAUCUAAA	UUUAGAUUUCUUCUUCGCC	Chmp	[828-846]
					3	UGCUGAAACUGAAAUUCAA	UUGAAUUUCAGUUUCAGCA	Chmp	[3176-3194]
4	UGAAGAAGCUGACAGUAAA	UUUACUGUCAGCUUCUUCA	Chmp	[2126-2144]
					5	GGUGAUCGGUAGCAACAAA	UUUGUUGCUACCGAUCACC	Chmp	[1953-1971]
6	UGGAAAAGAUGAAUAAGAA	UUCUUAUUCAUCUUUUCCA	Chmp	[1478-1496]
					7	GAAUGAAAUUAACUCUUAA	UUAAGAGUUAAUUUCAUUC	Chmp	[1736-1754]
8	GGAUAGUAAGCUUGAAAAA	UUUUUCAAGCUUACUAUCC	Chmp	[861-879]
					9	ACCUGAUCUGGAACAUCAA	UUGAUGUUCCAGAUCAGGU	Chmp	[899-917]
10	CGGUGAUCGGUAGCAACAA	UUGUUGCUACCGAUCACCG	Chmp	[1952-1970]
					11	CGCCCAUGUUUGAUGGAAA	UUUCCAUCAAACAUGGGCG	Chmp	[293-311]

12	CAAGGAUAGUAAGCUUGAA	UUCAAGCUUACUAUCCUUG	Chmp	[858-876]
					13	CAACAAAUCUGAAAAGAGA	UCUCUUUUCAGAUUUGUUG	Chmp	[1719-1737]
14	GGGUAGUACCUGUACUAAA	UUUAGUACAGGUACUACCC	Chmp	[3310-3328]
					15	GGGCAAGCACAGUGUCAAA	UUUGACACUGUGCUUGCCC	大鼠，Ms，Chmp	[3000-3018]
16	GCCCAUGUUUGAUGGAAAA	UUUUCCAUCAAACAUGGGC	Chmp	[294-312]
					17	CAAGGACGAGCUAAAGAAA	UUUCUUUAGCUCGUCCUUG	Chmp	[915-933]
18	GAAGAAAUCUAAAAAAGAA	UUCUUUUUUAGAUUUCUUC	Chmp	[834-852]
					19	UAGUAAUACUCGAUUAAAA	UUUUAAUCGAGUAUUACUA	Chmp	[3949-3967]
20	CAGAAAGGAUUUUACAGAA	UUCUGUAAAAUCCUUUCUG	Chmp	[3335-3353]
					21	CGAAGAAGAAAUCUAAAAA	UUUUUAGAUUUCUUCUUCG	Chmp	[830-848]
22	GGUGUAUGGAGAAGAUAGA	UCUAUCUUCUCCAUACACC	Chmp	[551-569]
					23	GGUUGACAGAGAUUCUGAA	UUCAGAAUCUCUGUCAACC	大鼠，Ms，Chmp	[2580-2598]
24	GAACCAACUCCUACUACAA	UUGUAGUAGGAGUUGGUUC		[1865-1883]
					25	CCUGGUGGACAUCGUUAAA	UUUAACGAUGUCCACCAGG	Chmp	[1845-1863]
26	GAUAGAGCGUGAAGGCGAA	UUCGCCUUCACGCUCUAUC	Chmp	[2685-2703]
					27	GGAACAAGGAUGAAGUGAA	UUCACUUCAUCCUUGUUCC	Chmp	[1379-1397]
28	UGUGGAUCCUGAUUCUGGA	UCCAGAAUCAGGAUCCACA	Chmp	[1767-1785]
					29	CAGGCUGCUUUGUCAAGAA	UUCUUGACAAAGCAGCCUG	Chmp	[650-668]
30	CAGGCUACAUGUUUGGUAA	UUACCAAACAUGUAGCCUG	Chmp	[2831-2849]
					31	AGCACUUCAUGAAAUUAUA	UAUAAUUUCAUGAAGUGCU	Chmp	[2006-2024]
32	GGUGGAUGGAGUGGAUGAA	UUCAUCCACUCCAUCCACC	Chmp	[807-825]
					33	GGUAGAUAAAACUGACAUA	UAUGUCAGUUUUAUCUACC	Chmp	[3451-3469]
34	GAAAUUGAAGGUUAAAAAA	UUUUUUAACCUUCAAUUUC		[1209-1227]
					35	CAGCAAGGAUCCCAUCGAU	AUCGAUGGGAUCCUUGCUG		[2526-2544]
36	AGUAAUACUCGAUUAAAAA	UUUUUAAUCGAGUAUUACU	Chmp	[3950-3968]
					37	AGGUGGAAAUGCUUGACAA	UUGUCAAGCAUUUCCACCU	Chmp	[2453-2471]
38	GUGGGAUGACCAGCAGAAA	UUUCUGCUGGUCAUCCCAC	Chmp	[405-423]

39	GCUGCGCUCUCCAAAAAAA	UUUUUUUGGAGAGCGCAGC	Chmp	[1672-1690]
					40	AGGUGGAAAAGAUGAAUAA	UUAUUCAUCUUUUCCACCU	Chmp	[1475-1493]
41	ACAUCAAGGACGAGCUAAA	UUUAGCUCGUCCUUGAUGU	Chmp	[911-929]
					42	GGACCAAGUGUAUGGUCAA	UUGACCAUACACUUGGUCC	Chmp	[1124-1142]
43	CGGUAGCAACAAACUGGAA	UUCCAGUUUGUUGCUACCG	Chmp	[1959-1977]
					44	AGGAGGAAGGUAUCAACAA	UUGUUGAUACCUUCCUCCU	Chmp	[1706-1724]
45	GUAUGGAGAAGAUAGAAAA	UUUUCUAUCUUCUCCAUAC	Chmp	[554-572]
					46	CGAGUACAUUGUCUAUGAU	AUCAUAGACAAUGUACUCG	Chmp	[3132-3150]
47	GAGUCAAGAGUGAAGGAAA	UUUCCUUCACUCUUGACUC	Chmp	[773-791]
					48	GAAGAAGAAAUCUAAAAAA	UUUUUUAGAUUUCUUCUUC	Chmp	[831-849]
49	CGCUCUCCAAAAAAAGCAA	UUGCUUUUUUUGGAGAGCG	Chmp	[1676-1694]
					50	AGGUAUCAACAAAUCUGAA	UUCAGAUUUGUUGAUACCU	Chmp	[1713-1731]
51	CCAAAGGAAUUCCGAGAAA	UUUCUCGGAAUUCCUUUGG	大鼠，Ms，Chmp	[1177-1195]
					52	GGCUAAUAGUAAUACUCGA	UCGAGUAUUACUAUUAGCC	Chmp	[3943-3961]
53	GAACAUGGGAGCUCUUGAA	UUCAAGAGCUCCCAUGUUC	Chmp	[3827-3845]
					54	UCAAGAAAUUGAAGGUUAA	UUAACCUUCAAUUUCUUGA	Chmp	[1205-1223]
55	UCUGGAGGACGACAAGGAA	UUCCUUGUCGUCCUCCAGA	Chmp	[1893-1911]
					56	GGUGGACAUCGUUAAAGGA	UCCUUUAACGAUGUCCACC	Chmp	[1848-1866]
57	CCAGGGAAGGAAAAAUACA	UGUAUUUUUCCUUCCCUGG		[3558-3576]
					58	AGAAAUUGAAGGUUAAAAA	UUUUUAACCUUCAAUUUCU	Chmp	[1208-1226]
59	GGAGAGAGAUUCUGUUGCA	UGCAACAGAAUCUCUCUCC	Chmp	[3481-3499]
					60	CAAUGCGUAUGACUUGGAA	UUCCAAGUCAUACGCAUUG	Chmp	[2649-2667]
61	AGAAGAUGGAGGAAGUAAA	UUUACUUCCUCCAUCUUCU	Chmp	[1493-1511]
					62	GAAACAUGUAUGAACUGAA	UUCAGUUCAUACAUGUUUC	Chmp	[2951-2969]
63	GAAGAAGCUGACAGUAAAU	AUUUACUGUCAGCUUCUUC	Chmp	[2127-2145]
					64	GAUGAUCUUUGAUGUGGAA	UUCCACAUCAAAGAUCAUC	Chmp	[2193-2211]
65	CUAUGAUAUUGCUCAGGUA	UACCUGAGCAAUAUCAUAG	Chmp	[3144-3162]

66	CUUUUGUCUUCCAAAUUAA	UUAAUUUGGAAGACAAAAG	Chmp	[3896-3914]
					67	GCAACAAACUGGAACAGAU	AUCUGUUCCAGUUUGUUGC	Chmp	[1964-1982]
68	GAAGGCAGAGCCUGUUGAA	UUCAACAGGCUCUGCCUUC	Chmp	[1626-1644]
					69	GAAAAGAGAAUGAAAUUAA	UUAAUUUCAUUCUCUUUUC	Chmp	[1729-1747]
70	CAAGAAAUUGAAGGUUAAA	UUUAACCUUCAAUUUCUUG	Chmp	[1206-1224]
					71	CAUUGAGCACUUCAUGAAA	UUUCAUGAAGUGCUCAAUG	Chmp	[2001-2019]
72	CCAAAAAUUUCACGAAGUA	UACUUCGUGAAAUUUUUGG		[2054-2072]
					73	GCGAAGAAGAAAUCUAAAA	UUUUAGAUUUCUUCUUCGC	Chmp	[829-847]
74	UGGAGGACGACAAGGAAAA	UUUUCCUUGUCGUCCUCCA	Chmp	[1895-1913]
					75	GGCUGCGCUCUCCAAAAAA	UUUUUUGGAGAGCGCAGCC	Chmp	[1671-1689]
76	CGCGCCUCUUGCAAGAAAU	AUUUCUUGCAAGAGGCGCG	大鼠，Ms，Chmp	[223-241]
					77	CUGGAGGACGACAAGGAAA	UUUCCUUGUCGUCCUCCAG	Chmp	[1894-1912]
78	AGCUCAAAACUGACAUUAA	UUAAUGUCAGUUUUGAGCU	大鼠，Chmp	[2558-2576]
					79	CGACAAGGAAAACAGGUAU	AUACCUGUUUUCCUUGUCG	Chmp	[1902-1920]
80	ACGACUUUGGGAUGAAGAA	UUCUUCAUCCCAAAGUCGU	Chmp	[2396-2414]
					81	CCUCUGCUUCAGCAGAUAA	UUAUCUGCUGAAGCAGAGG	Chmp	[1316-1334]
82	CCAGGUAGAUAAAACUGAC	GUCAGUUUUAUCUACCUGG	Chmp	[3448-3466]
					83	UGACAGAGAUUCUGAAGAA	UUCUUCAGAAUCUCUGUCA	Chmp	[2583-2601]
84	GGGCACUUUUGUCUUCCAA	UUGGAAGACAAAAGUGCCC	Chmp	[3891-3909]
					85	AAUUAAAACUCUACCACAA	UUGUGGUAGAGUUUUAAUU		[3909-3927]
86	GAGUGAAGGAAAGAGAAAA	UUUUCUCUUUCCUUCACUC	大鼠，Chmp	[780-798]
					87	AAGAGUGAAGGAAAGAGAA	UUCUCUUUCCUUCACUCUU	大鼠，Chmp	[778-796]
88	GAGGAAGGUAUCAACAAAU	AUUUGUUGAUACCUUCCUC	Chmp	[1708-1726]
					89	UGUGCAUCAGCACCAAAAA	UUUUUGGUGCUGAUGCACA	Chmp	[1454-1472]
90	CCACAAAUAUACUUACCCA	UGGGUAAGUAUAUUUGUGG		[3922-3940]
					91	GACCUGAUCUGGAACAUCA	UGAUGUUCCAGAUCAGGUC	Chmp	[898-916]
92	GUACUAAACCACCUCAGAA	UUCUGAGGUGGUUUAGUAC		[3321-3339]

93	AGGAUAGUAAGCUUGAAAA	UUUUCAAGCUUACUAUCCU	Chmp	[860-878]
					94	CAACUAUGAGAAGCUCAAA	UUUGAGCUUCUCAUAGUUG	大鼠，Chmp	[2547-2565]
95	AAGCCGAGAUCAUCAGGAA	UUCCUGAUGAUCUCGGCUU	Chmp	[2600-2618]
					96	GUAUGUUAAGAACACUCAU	AUGAGUGUUCUUAACAUAC	Chmp	[2619-2637]
97	UCCUGAUUCUGGACUGGAA	UUCCAGUCCAGAAUCAGGA	Chmp	[1773-1791]
					98	CCGAGAUCAUCAGGAAGUA	UACUUCCUGAUGAUCUCGG	Chmp	[2603-2621]
99	GAACAUCAAGGACGAGCUA	UAGCUCGUCCUUGAUGUUC	Chmp	[909-927]
					100	GUAUCUGCUGAAACUGAAA	UUUCAGUUUCAGCAGAUAC	Chmp	[3171-3189]
101	GGAUCUAUUUCGCUGACAU	AUGUCAGCGAAAUAGAUCC	Chmp	[2852-2870]
					102	GCCUGGUGGACAUCGUUAA	UUAACGAUGUCCACCAGGC	Chmp	[1844-1862]
103	GCUGAAACUGAAAUUCAAU	AUUGAAUUUCAGUUUCAGC	Chmp	[3177-3195]
					104	UGUGGAAAGUAUGAAGAAA	UUUCUUCAUACUUUCCACA	Chmp	[2205-2223]
105	GUACGGUGAUCGGUAGCAA	UUGCUACCGAUCACCGUAC	Chmp	[1949-1967]
					106	GACUCUGGGUGACUUUGCA	UGCAAAGUCACCCAGAGUC	Chmp	[495-513]
107	AGUAUCUGCUGAAACUGAA	UUCAGUUUCAGCAGAUACU	Chmp	[3170-3188]
					108	CAGGUAGAUAAAACUGACA	UGUCAGUUUUAUCUACCUG	Chmp	[3449-3467]
109	GUGUAUGGAGAAGAUAGAA	UUCUAUCUUCUCCAUACAC	Chmp	[552-570]
					110	GCAUCAGCACCAAAAAGGA	UCCUUUUUGGUGCUGAUGC	Chmp	[1457-1475]
111	CGAAGUAUCCCAAAAAGUU	AACUUUUUGGGAUACUUCG		[2066-2084]
					112	GCAGCUUCAUAACCGAAGA	UCUUCGGUUAUGAAGCUGC		[2727-2745]
113	GAUCCUUCAGCUAACAUUA	UAAUGUUAGCUGAAGGAUC	Chmp	[3040-3058]
					114	GAUGGAGGAAGUAAAGGAA	UUCCUUUACUUCCUCCAUC	Chmp	[1497-1515]
115	GGAACCAACUCCUACUACA	UGUAGUAGGAGUUGGUUCC		[1864-1882]
					116	CAGCAGAAAGUCAAGAAGA	UCUUCUUGACUUUCUGCUG	Chmp	[415-433]
117	CCUCAGAAAGGAUUUUACA	UGUAAAAUCCUUUCUGAGG	Chmp	[3332-3350]
					118	UGCUACAGAGGAUAAAGAA	UUCUUUAUCCUCUGUAGCA	Chmp	[732-750]
119	AGACUAGUCCUAUGGAAAA	UUUUCCAUAGGACUAGUCU		[3501-3519]

120	CCAACAGAAGUACGUGCAA	UUGCACGUACUUCUGUUGG	Chmp	[530-548]
					121	GUAUCAACAAAUCUGAAAA	UUUUCAGAUUUGUUGAUAC	Chmp	[1715-1733]
122	CCUUCUCCAGGAAUACUGA	UCAGUAUUCCUGGAGAAGG	Chmp	[3810-3828]
					123	GUGGAAAAGAUGAAUAAGA	UCUUAUUCAUCUUUUCCAC	Chmp	[1477-1495]
124	CAUCGAUAUCUUUAAGAUA	UAUCUUAAAGAUAUCGAUG		[2670-2688]
					125	CGAGAAAUCUCUUACCUCA	UGAGGUAAGAGAUUUCUCG	Chmp	[1189-1207]
126	CUUCAAGAGCGAUGCCUAU	AUAGGCAUCGCUCUUGAAG		[1080-1098]
					127	AGGAGGUGGAAAAGAUGAA	UUCAUCUUUUCCACCUCCU	Chmp	[1472-1490]
128	GGAUGAAGAGGCAGUGAAG	CUUCACUGCCUCUUCAUCC	Chmp	[2112-2130]
					129	AAAGGUUUGGGCAAAACUA	UAGUUUUGCCCAAACCUUU	Chmp	[3016-3034]
130	AAGUCAUCGAUAUCUUUAA	UUAAAGAUAUCGAUGACUU		[2666-2684]
					131	GAAAGAUGUUAAGCAUUUA	UAAAUGCUUAACAUCUUUC	Chmp	[3621-3639]
132	GGAGCUCUUGAAAUAUGUA	UACAUAUUUCAAGAGCUCC	Chmp	[3834-3852]
					133	UGAGGUGGAUGGAGUGGAU	AUCCACUCCAUCCACCUCA	Chmp	[804-822]
134	UGGUAUGAAUUCACCCGAA	UUCGGGUGAAUUCAUACCA	Chmp	[3251-3269]
					135	GCAAGUUACCCAAGGGCAA	UUGCCCUUGGGUAACUUGC	大鼠，Ms，Chmp	[2987-3005]
136	CCAAAAAGGAGGUGGAAAA	UUUUCCACCUCCUUUUUGG	Chmp	[1466-1484]
					137	GGCACUUUUGUCUUCCAAA	UUUGGAAGACAAAAGUGCC	Chmp	[3892-3910]
138	GGAGAAGUUGCCCUUGGAA	UUCCAAGGGCAACUUCUCC	大鼠，Chmp	[2935-2953]
					139	CUUCCAAAUUAAAACUCUA	UAGAGUUUUAAUUUGGAAG	Chmp	[3903-3921]
140	GAACACUCAUGCAACCACA	UGUGGUUGCAUGAGUGUUC	Chmp	[2628-2646]
					141	UCUCAUACUUAGAAACAAA	UUUGUUUCUAAGUAUGAGA	Chmp	[3782-3800]
142	AGAUGAAUAAGAAGAUGGA	UCCAUCUUCUUAUUCAUCU	Chmp	[1484-1502]
					143	AGAACGACCUGAUCUGGAA	UUCCAGAUCAGGUCGUUCU	Chmp	[893-911]
144	AGAAAAGGCUGGAGAGAGA	UCUCUCUCCAGCCUUUUCU	Chmp	[3471-3489]
					145	GAACAAGGAUGAAGUGAAG	CUUCACUUCAUCCUUGUUC	Chmp	[1380-1398]
146	CCUUUAAGCAGCUUCAUAA	UUAUGAAGCUGCUUAAAGG		[2720-2738]

147	UCAGGAAGUAUGUUAAGAA	UUCUUAACAUACUUCCUGA	Chmp	[2612-2630]
					148	ACACCUCUCUACUAUAUAA	UUAUAUAGUAGAGAGGUGU	Chmp	[3113-3131]
149	UGAUCUGGAACAUCAAGGA	UCCUUGAUGUUCCAGAUCA	Chmp	[902-920]
					150	AAUUGAAGGUUAAAAAACA	UGUUUUUUAACCUUCAAUU		[1211-1229]
151	AACAAAUCUGAAAAGAGAA	UUCUCUUUUCAGAUUUGUU	Chmp	[1720-1738]
					152	GAUUUUGGAAAGAUGUUAA	UUAACAUCUUUCCAAAAUC	Chmp	[3614-3632]
153	CCAAAGGAAGGAACGCUAA	UUAGCGUUCCUUCCUUUGG	Chmp	[3758-3776]
					154	AUCUGAAAAGAGAAUGAAA	UUUCAUUCUCUUUUCAGAU	Chmp	[1725-1743]
155	CUCUCAAAUCGCUUUUACA	UGUAAAAGCGAUUUGAGAG	Chmp	[2365-2383]
					156	AGAGUGAAGGAAAGAGAAA	UUUCUCUUUCCUUCACUCU	大鼠，Chmp	[779-797]
157	GAAGAAGCCGAGAUCAUCA	UGAUGAUCUCGGCUUCUUC	Chmp	[2596-2614]
					158	CAUGAAAUUAUAUGAAGAA	UUCUUCAUAUAAUUUCAUG	Chmp	[2013-2031]
159	GCUCAAAACUGACAUUAAG	CUUAAUGUCAGUUUUGAGC	大鼠，Chmp	[2559-2577]
					160	CAAGAGUGAAGGAAAGAGA	UCUCUUUCCUUCACUCUUG	大鼠，Chmp	[777-795]
161	ACGAGUACAUUGUCUAUGA	UCAUAGACAAUGUACUCGU	Chmp	[3131-3149]
					162	CAUGGGAGCUCUUGAAAUA	UAUUUCAAGAGCUCCCAUG	Chmp	[3830-3848]
163	CCAAGGUGGAAAUGCUUGA	UCAAGCAUUUCCACCUUGG	Chmp	[2450-2468]
					164	UCUGGAACAUCAAGGACGA	UCGUCCUUGAUGUUCCAGA	Chmp	[905-923]
165	UGUUAAAGGUUUUCUCUAA	UUAGAGAAAACCUUUAACA	Chmp	[3357-3375]
					166	GGUAUCAACAAAUCUGAAA	UUUCAGAUUUGUUGAUACC	Chmp	[1714-1732]
167	AGAAAGGAUUUUACAGAAA	UUUCUGUAAAAUCCUUUCU	Chmp	[3336-3354]
					168	GAUCCUGGAUCUCUCAAAU	AUUUGAGAGAUCCAGGAUC		[2355-2373]
169	GACUAGUCCUAUGGAAAAA	UUUUUCCAUAGGACUAGUC		[3502-3520]
					170	AAGGAAAAAUACACUUCCA	UGGAAGUGUAUUUUUCCUU		[3564-3582]
171	GGUGGUUGACAGAGAUUCU	AGAAUCUCUGUCAACCACC	大鼠，Ms，Chmp	[2577-2595]
					172	GGGUCUGAUGAUAGCAGCA	UGCUGCUAUCAUCAGACCC	Chmp	[2512-2530]
173	CUGCCUGGACCAAGUGUAU	AUACACUUGGUCCAGGCAG	Chmp	[1118-1136]

174	AGCGAUGCCUAUUACUGCA	UGCAGUAAUAGGCAUCGCU		[1087-1105]
					175	CCAUCGAUGUCAACUAUGA	UCAUAGUUGACAUCGAUGG	大鼠，Chmp	[2537-2555]
176	AGCUGUGGAUCCUGAUUCU	AGAAUCAGGAUCCACAGCU	Chmp	[1764-1782]
					177	AGGAGCUACUCAUCUUCAA	UUGAAGAUGAGUAGCUCCU	Chmp	[956-974]
178	CCCAAGGGCUAAUAGUAAU	AUUACUAUUAGCCCUUGGG	Chmp	[3937-3955]
					179	GAGAAAUCUCUUACCUCAA	UUGAGGUAAGAGAUUUCUC	Chmp	[1190-1208]
180	CCAUUAUCCAACAUGAAGA	UCUUCAUGUUGGAUAAUGG	Chmp	[1336-1354]
					181	ACCCAAGGGCUAAUAGUAA	UUACUAUUAGCCCUUGGGU	Chmp	[3936-3954]
182	AGAAGAAAUCUAAAAAAGA	UCUUUUUUAGAUUUCUUCU	Chmp	[833-851]
					183	UCAUCAGGAAGUAUGUUAA	UUAACAUACUUCCUGAUGA	Chmp	[2609-2627]
184	GCAGAAAGUCAAGAAGACA	UGUCUUCUUGACUUUCUGC	Chmp	[417-435]
					185	CCUUGCUACAGAGGAUAAA	UUUAUCCUCUGUAGCAAGG	Chmp	[729-747]
186	GAUUCUGUUGCAUAGACUA	UAGUCUAUGCAACAGAAUC	Chmp	[3488-3506]
					187	UCGCUGACAUGGUCUCCAA	UUGGAGACCAUGUCAGCGA	Chmp	[2861-2879]
188	CUCAUACUUAGAAACAAAA	UUUUGUUUCUAAGUAUGAG	Chmp	[3783-3801]
					189	CCAUUGAGCACUUCAUGAA	UUCAUGAAGUGCUCAAUGG	Chmp	[2000-2018]
190	GUCCUAUGGAAAAAACCAA	UUGGUUUUUUCCAUAGGAC		[3507-3525]
					191	AAGGAUAGUAAGCUUGAAA	UUUCAAGCUUACUAUCCUU	Chmp	[859-877]
192	AGGCUACAUGUUUGGUAAA	UUUACCAAACAUGUAGCCU	Chmp	[2832-2850]
					193	CUUGAAAUAUGUAGUAUUA	UAAUACUACAUAUUUCAAG	Chmp	[3840-3858]
194	AGAUGAUCUUUGAUGUGGA	UCCACAUCAAAGAUCAUCU	Chmp	[2192-2210]
					195	UCAUCAAGAUGAUCUUUGA	UCAAAGAUCAUCUUGAUGA	Chmp	[2186-2204]
196	AGCGUUACAAGCCCUUUAA	UUAAAGGGCUUGUAACGCU		[2708-2726]
					197	GGAAAACAGGUAUUGGAUA	UAUCCAAUACCUGUUUUCC	Chmp	[1908-1926]
198	GAUAAAACUGACAUAGAGA	UCUCUAUGUCAGUUUUAUC	Chmp	[3455-3473]
					199	GUACAUUGUCUAUGAUAUU	AAUAUCAUAGACAAUGUAC	Chmp	[3135-3153]
200	AGUCAAGAAGACAGCGGAA	UUCCGCUGUCUUCUUGACU	Chmp	[423-441]

201	AAGGAAAACAGGUAUUGGA	UCCAAUACCUGUUUUCCUU	Chmp	[1906-1924]
					202	AAGGAAGGAACGCUAACAA	UUGUUAGCGUUCCUUCCUU	Chmp	[3761-3779]
203	UGAGCAAAAGGCAGAUCCA	UGGAUCUGCCUUUUGCUCA	Chmp	[2273-2291]
					204	AUUAAAAGUUGCAUUUGAA	UUCAAAUGCAACUUUUAAU	Chmp	[3855-3873]
205	CAGCGUUACAAGCCCUUUA	UAAAGGGCUUGUAACGCUG		[2707-2725]
					206	CAACUAAUGACCUGAAGGA	UCCUUCAGGUCAUUAGUUG	Chmp	[941-959]
207	UCGAUAUCUUUAAGAUAGA	UCUAUCUUAAAGAUAUCGA		[2672-2690]
					208	GGAAGUCAUCGAUAUCUUU	AAAGAUAUCGAUGACUUCC		[2664-2682]
209	AUGUGGAAAGUAUGAAGAA	UUCUUCAUACUUUCCACAU	Chmp	[2204-2222]
					210	AGAUAAAACUGACAUAGAG	CUCUAUGUCAGUUUUAUCU	Chmp	[3454-3472]
211	UCAAGGACGAGCUAAAGAA	UUCUUUAGCUCGUCCUUGA	Chmp	[914-932]
					212	CCUUGGAAACAUGUAUGAA	UUCAUACAUGUUUCCAAGG	Ms，Chmp	[2946-2964]
213	GGAAAAGAUGAAUAAGAAG	CUUCUUAUUCAUCUUUUCC	Chmp	[1479-1497]
					214	AAACUCUACCACAAAUAUA	UAUAUUUGUGGUAGAGUUU		[3914-3932]
215	CCGUGACAGGCUACAUGUU	AACAUGUAGCCUGUCACGG	Chmp	[2825-2843]
					216	AGCAGCUGUGGAUCCUGAU	AUCAGGAUCCACAGCUGCU	Chmp	[1761-1779]
217	GUGAAGAAGCUGACAGUAA	UUACUGUCAGCUUCUUCAC	Chmp	[2125-2143]
					218	GGGUGUAUGGAGAAGAUAG	CUAUCUUCUCCAUACACCC	Chmp	[550-568]
219	GGUCAGCUGGUCUUCAAGA	UCUUGAAGACCAGCUGACC	Chmp	[1069-1087]
					220	CAUUAAGGUGGUUGACAGA	UCUGUCAACCACCUUAAUG	大鼠，Ms，Chmp	[2571-2589]
221	CAGUUCAGGACCUCAUCAA	UUGAUGAGGUCCUGAACUG	Chmp	[2174-2192]
					222	AGCUGGUCUUCAAGAGCGA	UCGCUCUUGAAGACCAGCU	Chmp	[1073-1091]
223	AAGGAGGAAGGUAUCAACA	UGUUGAUACCUUCCUCCUU	Chmp	[1705-1723]
					224	GAAUGACACCUCUCUACUA	UAGUAGAGAGGUGUCAUUC	Chmp	[3108-3126]
225	GCUGGAGAGAGAUUCUGUU	AACAGAAUCUCUCUCCAGC	Chmp	[3478-3496]
					226	CAUACUCCAUCCUCAGUGA	UCACUGAGGAUGGAGUAUG	Chmp	[2297-2315]
227	UCACGAAGUAUCCCAAAAA	UUUUUGGGAUACUUCGUGA		[2063-2081]

228	CACAGCUAGGCAUGAUUGA	UCAAUCAUGCCUAGCUGUG	Chmp	[617-635]
					229	GGCAGAGCCUGUUGAAGUU	AACUUCAACAGGCUCUGCC	Chmp	[1629-1647]
230	AAACCAAGCUUCGUUAGAA	UUCUAACGAAGCUUGGUUU	Chmp	[3519-3537]
					231	GCUUAAUCCUGUUGGGAGA	UCUCCCAACAGGAUUAAGC	Chmp	[2921-2939]
232	CUUCCACCCUUUUUUCUAA	UUAGAAAAAAGGGUGGAAG	Chmp	[3577-3595]
					233	GGUUGUUUUUGUUUUUUCU	AGAAAAAACAAAAACAACC	Chmp	[3427-3445]
234	CUUACCUCAAGAAAUUGAA	UUCAAUUUCUUGAGGUAAG	Chmp	[1199-1217]
					235	UGAUGAUAGCAGCAAGGAU	AUCCUUGCUGCUAUCAUCA		[2517-2535]
236	UGUUAAGAACACUCAUGCA	UGCAUGAGUGUUCUUAACA	Chmp	[2622-2640]
					237	CUUUAGUUUUGAUUUUGGA	UCCAAAAUCAAAACUAAAG	Chmp	[3604-3622]
238	CUCCAGGAAUACUGAACAU	AUGUUCAGUAUUCCUGGAG	Chmp	[3814-3832]
					239	GUGUCAAAGGUUUGGGCAA	UUGCCCAAACCUUUGACAC	大鼠，Chmp	[3011-3029]
240	CUAAAAAAGAAAAAGACAA	UUGUCUUUUUCUUUUUUAG	Chmp	[842-860]
					241	GAAAUUAACUCUUAAAGGA	UCCUUUAAGAGUUAAUUUC	Chmp	[1740-1758]
242	CCCAAAGGAAUUCCGAGAA	UUCUCGGAAUUCCUUUGGG	Chmp	[1176-1194]
					243	CACAAAUAUACUUACCCAA	UUGGGUAAGUAUAUUUGUG		[3923-3941]
244	GCACUUUUGUCUUCCAAAU	AUUUGGAAGACAAAAGUGC	Chmp	[3893-3911]
					245	AACAGGUAUUGGAUAUUCA	UGAAUAUCCAAUACCUGUU	Chmp	[1912-1930]
246	UUUUGUCUUCCAAAUUAAA	UUUAAUUUGGAAGACAAAA	Chmp	[3897-3915]
					247	CAUUGUCUAUGAUAUUGCU	AGCAAUAUCAUAGACAAUG	Chmp	[3138-3156]
248	AAAAGAUGAAUAAGAAGAU	AUCUUCUUAUUCAUCUUUU	Chmp	[1481-1499]
					249	GAGCUUUCCUUCUCCAGGA	UCCUGGAGAAGGAAAGCUC	Chmp	[3803-3821]
250	CCAAGAGCCUUCAGGAGUU	AACUCCUGAAGGCUCUUGG	Chmp	[1568-1586]
					251	GGAAGUAUGUUAAGAACAC	GUGUUCUUAACAUACUUCC	Chmp	[2615-2633]
252	AAGGUAUCAACAAAUCUGA	UCAGAUUUGUUGAUACCUU	Chmp	[1712-1730]
					253	CUGAAGAAGCCGAGAUCAU	AUGAUCUCGGCUUCUUCAG	Chmp	[2594-2612]
254	CAAAGGAAUUCCGAGAAAU	AUUUCUCGGAAUUCCUUUG	大鼠，Ms，Chmp	[1178-1196]

255	CCUCCUUGCUACAGAGGAU	AUCCUCUGUAGCAAGGAGG	Chmp	[726-744]
					256	UCAUACUUAGAAACAAAAA	UUUUUGUUUCUAAGUAUGA	Chmp	[3784-3802]
257	GGGAGCUCUUGAAAUAUGU	ACAUAUUUCAAGAGCUCCC	Chmp	[3833-3851]
					258	CAGUGAAGAAGCUGACAGU	ACUGUCAGCUUCUUCACUG	Chmp	[2123-2141]
259	CCAUGGUGGAGUAUGAGAU	AUCUCAUACUCCACCAUGG	Chmp	[2225-2243]
					260	CACUUCUCCUGCUUCUGGA	UCCAGAAGCAGGAGAAGUG	大鼠，Ms，Chmp	[328-346]
261	AGGACCUCAUCAAGAUGAU	AUCAUCUUGAUGAGGUCCU	Chmp	[2180-2198]
					262	GGAGGUGGAAAAGAUGAAU	AUUCAUCUUUUCCACCUCC	Chmp	[1473-1491]
263	CCCAGGAGUCAAGAGUGAA	UUCACUCUUGACUCCUGGG	Chmp	[768-786]
					264	CCAAAUUAAAACUCUACCA	UGGUAGAGUUUUAAUUUGG		[3906-3924]
265	CUUCUCCAGGAAUACUGAA	UUCAGUAUUCCUGGAGAAG	Chmp	[3811-3829]
					266	CGUCUUUAGUUUUGAUUUU	AAAAUCAAAACUAAAGACG	Chmp	[3601-3619]
267	CACGCUUCACAUAUCAGCA	UGCUGAUAUGUGAAGCGUG	Chmp	[2971-2989]
					268	CAAGAGCGAUGCCUAUUAC	GUAAUAGGCAUCGCUCUUG		[1083-1101]
269	AAAAAGACAAGGAUAGUAA	UUACUAUCCUUGUCUUUUU	Chmp	[851-869]
					270	CCCUGAUCCUUCAGCUAAC	GUUAGCUGAAGGAUCAGGG	Chmp	[3036-3054]
271	CCCGGAACAAGGAUGAAGU	ACUUCAUCCUUGUUCCGGG	Chmp	[1376-1394]
					272	GAGAGAGAUUCUGUUGCAU	AUGCAACAGAAUCUCUCUC	Chmp	[3482-3500]
273	CUGAAAAGAGAAUGAAAUU	AAUUUCAUUCUCUUUUCAG	Chmp	[1727-1745]
					274	CGUAUGACUUGGAAGUCAU	AUGACUUCCAAGUCAUACG	Chmp	[2654-2672]
275	UAAGGUGGUUGACAGAGAU	AUCUCUGUCAACCACCUUA	大鼠，Ms，Chmp	[2574-2592]
					276	GAGUACAUUGUCUAUGAUA	UAUCAUAGACAAUGUACUC	Chmp	[3133-3151]
277	UCAGCAAUCUAUCAGGGAA	UUCCCUGAUAGAUUGCUGA		[6-24]
					278	GUUGCAUAGACUAGUCCUA	UAGGACUAGUCUAUGCAAC		[3494-3512]
279	CGCUCCUGAACAAUGCAGA	UCUGCAUUGUUCAGGAGCG		[2420-2438]
					280	GGACGACAAGGAAAACAGG	CCUGUUUUCCUUGUCGUCC	Chmp	[1899-1917]
281	GCACUUCAUGAAAUUAUAU	AUAUAAUUUCAUGAAGUGC	Chmp	[2007-2025]

282	AUGAGAAGCUCAAAACUGA	UCAGUUUUGAGCUUCUCAU	大鼠，Chmp	[2552-2570]
					283	UAGAUAAAACUGACAUAGA	UCUAUGUCAGUUUUAUCUA	Chmp	[3453-3471]
284	CGAUGUCAACUAUGAGAAG	CUUCUCAUAGUUGACAUCG	大鼠，Chmp	[2541-2559]
					285	AUGAAGAGGCAGUGAAGAA	UUCUUCACUGCCUCUUCAU	Chmp	[2114-2132]
286	UGCGCAUGUCCUGGAGAAA	UUUCUCCAGGACAUGCGCA	Chmp	[1797-1815]
					287	GGGAAGGAAAAAUACACUU	AAGUGUAUUUUUCCUUCCC		[3561-3579]
288	GAACUCCUCUGCUUCAGCA	UGCUGAAGCAGAGGAGUUC	Chmp	[1311-1329]
					289	CAGGAAGUAUGUUAAGAAC	GUUCUUAACAUACUUCCUG	Chmp	[2613-2631]
290	CCUGAACAAUGCAGACAGU	ACUGUCUGCAUUGUUCAGG	Chmp	[2424-2442]
					291	AUGAGAUCGACCUUCAGAA	UUCUGAAGGUCGAUCUCAU	Chmp	[2237-2255]
292	CAUCCAGGCUGCUUUGUCA	UGACAAAGCAGCCUGGAUG		[646-664]
					293	GAUGAAGAGGCAGUGAAGA	UCUUCACUGCCUCUUCAUC	Chmp	[2113-2131]
294	AGGUCAAGGAGGAAGGUAU	AUACCUUCCUCCUUGACCU	Chmp	[1700-1718]
					295	GGAAGGUAUCAACAAAUCU	AGAUUUGUUGAUACCUUCC	Chmp	[1710-1728]
296	CAUAGACUAGUCCUAUGGA	UCCAUAGGACUAGUCUAUG		[3498-3516]
					297	UGGAACAGAUGCCGUCCAA	UUGGACGGCAUCUGUUCCA	Chmp	[1973-1991]
298	UGGAGGAGUGACAGGCAAA	UUUGCCUGUCACUCCUCCA	Chmp	[444-462]
					299	AGCUACUCAUCUUCAACAA	UUGUUGAAGAUGAGUAGCU	Chmp	[959-977]
300	AAUAGUAAUACUCGAUUAA	UUAAUCGAGUAUUACUAUU	Chmp	[3947-3965]
					301	AGAUCGACCUUCAGAAGAU	AUCUUCUGAAGGUCGAUCU	Chmp	[2240-2258]
302	AAAAGAGAAUGAAAUUAAC	GUUAAUUUCAUUCUCUUUU	Chmp	[1730-1748]
					303	GAACGCUAACAAUUUCUCA	UGAGAAAUUGUUAGCGUUC	Chmp	[3768-3786]
304	CCAAGGGCUAAUAGUAAUA	UAUUACUAUUAGCCCUUGG	Chmp	[3938-3956]
					305	CUGUGCAUCAGCACCAAAA	UUUUGGUGCUGAUGCACAG	Chmp	[1453-1471]
306	AGGAUCCCAUCGAUGUCAA	UUGACAUCGAUGGGAUCCU		[2531-2549]
					307	AAAUCUGAAAAGAGAAUGA	UCAUUCUCUUUUCAGAUUU	Chmp	[1723-1741]
308	CCUGAUCCUUCAGCUAACA	UGUUAGCUGAAGGAUCAGG	Chmp	[3037-3055]

309	UUUACAGAAACGUGUUAAA	UUUAACACGUUUCUGUAAA	Chmp	[3345-3363]
					310	CAGCUAACAUUAGUCUGGA	UCCAGACUAAUGUUAGCUG	Chmp	[3047-3065]
311	GAGGCAGUGAAGAAGCUGA	UCAGCUUCUUCACUGCCUC	Chmp	[2119-2137]
					312	CACGAAGUAUCCCAAAAAG	CUUUUUGGGAUACUUCGUG		[2064-2082]
313	AGAGAGAUUCUGUUGCAUA	UAUGCAACAGAAUCUCUCU	Chmp	[3483-3501]
					314	CCCACGACUUUGGGAUGAA	UUCAUCCCAAAGUCGUGGG	Chmp	[2393-2411]
315	GGUUUUCUCUAACUUCUCA	UGAGAAGUUAGAGAAAACC	Chmp	[3364-3382]
					316	CUCCCUGUGGUAAUUGGGA	UCCCAAUUACCACAGGGAG	Chmp	[3204-3222]
317	GAAACGUGUUAAAGGUUUU	AAAACCUUUAACACGUUUC	Chmp	[3351-3369]
					318	GGCUGCUUUGUCAAGAACA	UGUUCUUGACAAAGCAGCC	Chmp	[652-670]
319	GUGACUUUGCAGCAGAGUA	UACUCUGCUGCAAAGUCAC	Chmp	[503-521]
					320	GGAUGGUGUAGACGUUCCU	AGGAACGUCUACACCAUCC		[3063-3081]
321	AUUAAAACUCUACCACAAA	UUUGUGGUAGAGUUUUAAU		[3910-3928]
					322	GUCAAAGGUUUGGGCAAAA	UUUUGCCCAAACCUUUGAC	大鼠，Chmp	[3013-3031]
323	GUUCGUCUUUAGUUUUGAU	AUCAAAACUAAAGACGAAC	Chmp	[3598-3616]
					324	GGAGGACGACAAGGAAAAC	GUUUUCCUUGUCGUCCUCC	Chmp	[1896-1914]
325	CAGGAAUACUGAACAUGGG	CCCAUGUUCAGUAUUCCUG	Chmp	[3817-3835]
					326	UGAUAUUGCUCAGGUAAAU	AUUUACCUGAGCAAUAUCA	Chmp	[3147-3165]
327	AACCAAGCUUCGUUAGAAU	AUUCUAACGAAGCUUGGUU	Chmp	[3520-3538]
					328	AGGAUGAAGAGGCAGUGAA	UUCACUGCCUCUUCAUCCU	Chmp	[2111-2129]
329	GAGGUGGAAAAGAUGAAUA	UAUUCAUCUUUUCCACCUC	Chmp	[1474-1492]
					330	CGUUAGAAUGUCUGCCUUA	UAAGGCAGACAUUCUAACG	Chmp	[3530-3548]
331	GAGAGAUUCUGUUGCAUAG	CUAUGCAACAGAAUCUCUC	Chmp	[3484-3502]
					332	UGUACUAAACCACCUCAGA	UCUGAGGUGGUUUAGUACA		[3320-3338]
333	GAUUCUGAAGAAGCCGAGA	UCUCGGCUUCUUCAGAAUC	Chmp	[2590-2608]
					334	AGUACAUUGUCUAUGAUAU	AUAUCAUAGACAAUGUACU	Chmp	[3134-3152]
335	AGAUGUUAAGCAUUUAUUU	AAAUAAAUGCUUAACAUCU	Chmp	[3624-3642]

336	GUUCAACUAAUGACCUGAA	UUCAGGUCAUUAGUUGAAC	Chmp	[938-956]
					337	CAUUAUCCAACAUGAAGAU	AUCUUCAUGUUGGAUAAUG	Chmp	[1337-1355]
338	CAGAGAAGACUCUGGGUGA	UCACCCAGAGUCUUCUCUG	Chmp	[488-506]
					339	AAAACUCUACCACAAAUAU	AUAUUUGUGGUAGAGUUUU		[3913-3931]
340	GAAUAAGAAGAUGGAGGAA	UUCCUCCAUCUUCUUAUUC	Chmp	[1488-1506]
					341	CACGACUUUGGGAUGAAGA	UCUUCAUCCCAAAGUCGUG	Chmp	[2395-2413]
342	UCAAGAGCGAUGCCUAUUA	UAAUAGGCAUCGCUCUUGA		[1082-1100]
					343	CAAUUUCUCAUACUUAGAA	UUCUAAGUAUGAGAAAUUG	Chmp	[3777-3795]
344	CGGAGUCUUCGGAUAAGCU	AGCUUAUCCGAAGACUCCG	Chmp	[176-194]
					345	CAAGGAGGAAGGUAUCAAC	GUUGAUACCUUCCUCCUUG	Chmp	[1704-1722]
346	CUGACAUUAAGGUGGUUGA	UCAACCACCUUAAUGUCAG	大鼠，Ms，Chmp	[2567-2585]
					347	AGGAGUUGUUCUUAGCGCA	UGCGCUAAGAACAACUCCU	Chmp	[1580-1598]
348	AACUAUGAGAAGCUCAAAA	UUUUGAGCUUCUCAUAGUU	大鼠，Chmp	[2548-2566]
					349	UCCUCUGCUUCAGCAGAUA	UAUCUGCUGAAGCAGAGGA	Chmp	[1315-1333]
350	CAUCAAGGACGAGCUAAAG	CUUUAGCUCGUCCUUGAUG	Chmp	[912-930]
					351	AGGAAGGAACGCUAACAAU	AUUGUUAGCGUUCCUUCCU	Chmp	[3762-3780]
352	GAGAAGUUGCCCUUGGAAA	UUUCCAAGGGCAACUUCUC	大鼠，Chmp	[2936-2954]
					353	CUGCUGAAACUGAAAUUCA	UGAAUUUCAGUUUCAGCAG	Chmp	[3175-3193]
354	AGUUGUUCUUAGCGCACAU	AUGUGCGCUAAGAACAACU	Chmp	[1583-1601]
					355	GGCAGUGAAGAAGCUGACA	UGUCAGCUUCUUCACUGCC	Chmp	[2121-2139]
356	GGAAGCUGAGCAAAAGGCA	UGCCUUUUGCUCAGCUUCC		[2267-2285]
					357	CGGAUAAGCUCUAUCGAGU	ACUCGAUAGAGCUUAUCCG	Chmp	[185-203]
358	UGCAGUCGCCCAUGUUUGA	UCAAACAUGGGCGACUGCA	Chmp	[287-305]
					359	UCAACUAUGAGAAGCUCAA	UUGAGCUUCUCAUAGUUGA	大鼠，Chmp	[2546-2564]
360	GAAGGAACGCUAACAAUUU	AAAUUGUUAGCGUUCCUUC	Chmp	[3764-3782]
					361	GGUGGAAAUGCUUGACAAC	GUUGUCAAGCAUUUCCACC	Chmp	[2454-2472]
362	GCAGCUGUGGAUCCUGAUU	AAUCAGGAUCCACAGCUGC	Chmp	[1762-1780]

363	CAUUAGUCUGGAUGGUGUA	UACACCAUCCAGACUAAUG	Chmp	[3054-3072]
					364	AGGUGGAUGGAGUGGAUGA	UCAUCCACUCCAUCCACCU	Chmp	[806-824]
365	AUAGUAAUACUCGAUUAAA	UUUAAUCGAGUAUUACUAU	Chmp	[3948-3966]
					366	CACCAAAAAGGAGGUGGAA	UUCCACCUCCUUUUUGGUG	Chmp	[1464-1482]
367	AGGAAAACAGGUAUUGGAU	AUCCAAUACCUGUUUUCCU	Chmp	[1907-1925]
					368	AAAUUAAAACUCUACCACA	UGUGGUAGAGUUUUAAUUU		[3908-3926]
369	CCCUAAAGGCUCAGAACGA	UCGUUCUGAGCCUUUAGGG	Chmp	[881-899]
					370	GUGGUAAUUGGGAGAGGUA	UACCUCUCCCAAUUACCAC	Chmp	[3210-3228]
371	AGGGCAAGCACAGUGUCAA	UUGACACUGUGCUUGCCCU	大鼠，Ms，Chmp	[2999-3017]
					372	GUGUUAAAGGUUUUCUCUA	UAGAGAAAACCUUUAACAC	Chmp	[3356-3374]
373	GGUAGUACCUGUACUAAAC	GUUUAGUACAGGUACUACC	Chmp	[3311-3329]
					374	GUGGACAUCGUUAAAGGAA	UUCCUUUAACGAUGUCCAC	Chmp	[1849-1867]
375	GAAAAGAUGAAUAAGAAGA	UCUUCUUAUUCAUCUUUUC	Chmp	[1480-1498]
					376	CUGAAAUUCAAUUUUAAGA	UCUUAAAAUUGAAUUUCAG	Chmp	[3184-3202]
377	AUAGACUAGUCCUAUGGAA	UUCCAUAGGACUAGUCUAU		[3499-3517]
					378	GCUCUUGAAAUAUGUAGUA	UACUACAUAUUUCAAGAGC	Chmp	[3837-3855]
379	ACGACAAGGAAAACAGGUA	UACCUGUUUUCCUUGUCGU	Chmp	[1901-1919]
					380	AUAUCAGCAAGUUACCCAA	UUGGGUAACUUGCUGAUAU	Ms，Chmp	[2981-2999]
381	GGAAGGAACGCUAACAAUU	AAUUGUUAGCGUUCCUUCC	Chmp	[3763-3781]
					382	UAACGAGUACAUUGUCUAU	AUAGACAAUGUACUCGUUA	Chmp	[3129-3147]
383	CCCUUUAAGCAGCUUCAUA	UAUGAAGCUGCUUAAAGGG		[2719-2737]
					384	GCUUUGUCAAGAACAGGGA	UCCCUGUUCUUGACAAAGC	Chmp	[656-674]
385	UCUUCAAGAGCGAUGCCUA	UAGGCAUCGCUCUUGAAGA		[1079-1097]
					386	CGAGAUCAUCAGGAAGUAU	AUACUUCCUGAUGAUCUCG	Chmp	[2604-2622]
387	GGAUUUUACAGAAACGUGU	ACACGUUUCUGUAAAAUCC	Chmp	[3341-3359]
					388	CUAAUUUCAUACUAUUUAG	CUAAAUAGUAUGAAAUUAG	Chmp	[3660-3678]
389	AGUUGCAUUUGAAAUUCUU	AAGAAUUUCAAAUGCAACU	Chmp	[3861-3879]

390	ACAGUGCGAGUCAGCUCAA	UUGAGCUGACUCGCACUGU	Chmp	[698-716]
					391	CUCCUCUGCUUCAGCAGAU	AUCUGCUGAAGCAGAGGAG	Chmp	[1314-1332]
392	UGAAAUUCUUGACUUUCUU	AAGAAAGUCAAGAAUUUCA	Chmp	[3870-3888]
					393	GGAACAUCAAGGACGAGCU	AGCUCGUCCUUGAUGUUCC	Chmp	[908-926]
394	GGUGGAAAAGAUGAAUAAG	CUUAUUCAUCUUUUCCACC	Chmp	[1476-1494]
					395	AACCGGAAGGAGUGGGUAA	UUACCCACUCCUUCCGGUU	Chmp	[1156-1174]
396	CUUGGACCGAGUAGCUGAU	AUCAGCUACUCGGUCCAAG		[1008-1026]
					397	GGAAGACCAAAGGAAGGAA	UUCCUUCCUUUGGUCUUCC	Chmp	[3752-3770]
398	GCUGCUUUGUCAAGAACAG	CUGUUCUUGACAAAGCAGC	Chmp	[653-671]
					399	AGGAAUACUGAACAUGGGA	UCCCAUGUUCAGUAUUCCU	Chmp	[3818-3836]
400	GGCUGGAGAGAGAUUCUGU	ACAGAAUCUCUCUCCAGCC	Chmp	[3477-3495]
					401	GAAUUGGUAGCAAGGCAGA	UCUGCCUUGCUACCAAUUC	Chmp	[473-491]
402	GUAGCAACAAACUGGAACA	UGUUCCAGUUUGUUGCUAC	Chmp	[1961-1979]
					403	CAAGCACAGUGUCAAAGGU	ACCUUUGACACUGUGCUUG	大鼠，Ms，Chmp	[3003-3021]
404	GGAUGGAGUGGAUGAAGUG	CACUUCAUCCACUCCAUCC	Chmp	[810-828]
					405	GAAGUAUGUUAAGAACACU	AGUGUUCUUAACAUACUUC	Chmp	[2616-2634]
406	CCUGAUCUGGAACAUCAAG	CUUGAUGUUCCAGAUCAGG	Chmp	[900-918]
					407	GUUAAGAACACUCAUGCAA	UUGCAUGAGUGUUCUUAAC	Chmp	[2623-2641]
408	CCCUGUGGUAAUUGGGAGA	UCUCCCAAUUACCACAGGG	Chmp	[3206-3224]
					409	UACCCAAGGGCUAAUAGUA	UACUAUUAGCCCUUGGGUA	Chmp	[3935-3953]
410	GAGCACUUCAUGAAAUUAU	AUAAUUUCAUGAAGUGCUC	Chmp	[2005-2023]
					411	GAAAAAGACAAGGAUAGUA	UACUAUCCUUGUCUUUUUC	Chmp	[850-868]
412	GGUAGCAAGGCAGAGAAGA	UCUUCUCUGCCUUGCUACC	Chmp	[478-496]
					413	GAAGAUGGAGGAAGUAAAG	CUUUACUUCCUCCAUCUUC	Chmp	[1494-1512]
414	AGUCCUAUGGAAAAAACCA	UGGUUUUUUCCAUAGGACU		[3506-3524]
					415	CGUGUUAAAGGUUUUCUCU	AGAGAAAACCUUUAACACG	Chmp	[3355-3373]
416	GGAUGGAAUUGGUAGCAAG	CUUGCUACCAAUUCCAUCC	Chmp	[468-486]

417	UACUAAACCACCUCAGAAA	UUUCUGAGGUGGUUUAGUA		[3322-3340]
					418	AUGAUAUUGCUCAGGUAAA	UUUACCUGAGCAAUAUCAU	Chmp	[3146-3164]
419	GACACCUCUCUACUAUAUA	UAUAUAGUAGAGAGGUGUC	Chmp	[3112-3130]
					420	AGAUCAUCAGGAAGUAUGU	ACAUACUUCCUGAUGAUCU	Chmp	[2606-2624]
421	GGUCAAGGAGGAAGGUAUC	GAUACCUUCCUCCUUGACC	Chmp	[1701-1719]
					422	AGGAGUCAAGAGUGAAGGA	UCCUUCACUCUUGACUCCU	Chmp	[771-789]
423	UUGCUCAGGUAAAUCUGAA	UUCAGAUUUACCUGAGCAA	Chmp	[3152-3170]
					424	GAAAUUCUUGACUUUCUUA	UAAGAAAGUCAAGAAUUUC	Chmp	[3871-3889]
425	AGACAAGGAUAGUAAGCUU	AAGCUUACUAUCCUUGUCU	Chmp	[855-873]
					426	AGCAGAAAGUCAAGAAGAC	GUCUUCUUGACUUUCUGCU	Chmp	[416-434]
427	UUAAAAGUUGCAUUUGAAA	UUUCAAAUGCAACUUUUAA	Chmp	[3856-3874]
					428	ACUUCUCCUGCUUCUGGAA	UUCCAGAAGCAGGAGAAGU	大鼠，Ms，Chmp	[329-347]
429	AGCUUGAAAAAGCCCUAAA	UUUAGGGCUUUUUCAAGCU	Chmp	[869-887]
					430	ACAGAAACGUGUUAAAGGU	ACCUUUAACACGUUUCUGU	Chmp	[3348-3366]
431	UAGACUAGUCCUAUGGAAA	UUUCCAUAGGACUAGUCUA		[3500-3518]
					432	AGGUAAAUCUGAAGUAUCU	AGAUACUUCAGAUUUACCU	Chmp	[3158-3176]
433	CCCUUGGAAACAUGUAUGA	UCAUACAUGUUUCCAAGGG	Ms，Chmp	[2945-2963]
					434	GGAGUAUGAGAUCGACCUU	AAGGUCGAUCUCAUACUCC	Chmp	[2232-2250]
435	UGGGUAGUACCUGUACUAA	UUAGUACAGGUACUACCCA	Chmp	[3309-3327]
					436	UAAGCAGCUUCAUAACCGA	UCGGUUAUGAAGCUGCUUA		[2724-2742]
437	GGUGGAGUAUGAGAUCGAC	GUCGAUCUCAUACUCCACC	Chmp	[2229-2247]
					438	GCCUCUUGCAAGAAAUGCA	UGCAUUUCUUGCAAGAGGC	大鼠，Ms，Chmp	[226-244]
439	AAAAGGAGGUGGAAAAGAU	AUCUUUUCCACCUCCUUUU	Chmp	[1469-1487]
					440	GUAUGAGAUCGACCUUCAG	CUGAAGGUCGAUCUCAUAC	Chmp	[2235-2253]
441	UGGGCACUUUUGUCUUCCA	UGGAAGACAAAAGUGCCCA	Chmp	[3890-3908]
					442	CAGGGAAGGAAAAAUACAC	GUGUAUUUUUCCUUCCCUG		[3559-3577]
443	UUGGUAGCAAGGCAGAGAA	UUCUCUGCCUUGCUACCAA	Chmp	[476-494]

444	AGUAUGAGAUCGACCUUCA	UGAAGGUCGAUCUCAUACU	Chmp	[2234-2252]
					445	ACUCCAAAAAUUUCACGAA	UUCGUGAAAUUUUUGGAGU	Chmp	[2051-2069]
446	GCCUGUCCAAGAAGAUGGU	ACCAUCUUCUUGGACAGGC	Ms	[584-602]
					447	AGGCAUCAGCAAUCUAUCA	UGAUAGAUUGCUGAUGCCU		[1-19]
448	GUCCCGGAACAAGGAUGAA	UUCAUCCUUGUUCCGGGAC	Chmp	[1374-1392]
					449	CUUCAUGAAAUUAUAUGAA	UUCAUAUAAUUUCAUGAAG	Chmp	[2010-2028]
450	UUGGAAAGAUGUUAAGCAU	AUGCUUAACAUCUUUCCAA	Chmp	[3618-3636]
					451	AGCUCUAUCGAGUCGAGUA	UACUCGACUCGAUAGAGCU	Chmp	[191-209]
452	ACCAGCAGAAAGUCAAGAA	UUCUUGACUUUCUGCUGGU	Chmp	[413-431]
					453	UGAACAUGGGAGCUCUUGA	UCAAGAGCUCCCAUGUUCA	Chmp	[3826-3844]
454	GGAAAGAUGUUAAGCAUUU	AAAUGCUUAACAUCUUUCC	Chmp	[3620-3638]
					455	GUUUGAUGGAAAAGUCCCA	UGGGACUUUUCCAUCAAAC	Chmp	[300-318]
456	AAGAAAUUGAAGGUUAAAA	UUUUAACCUUCAAUUUCUU	Chmp	[1207-1225]
					457	CCUGUGCAUCAGCACCAAA	UUUGGUGCUGAUGCACAGG	Chmp	[1452-1470]
458	GAUAAAGAAGCCCUGAAGA	UCUUCAGGGCUUCUUUAUC	Chmp	[742-760]
					459	AGAAUGAAAUUAACUCUUA	UAAGAGUUAAUUUCAUUCU	Chmp	[1735-1753]
460	GCAUGAUUGACCGCUGGUA	UACCAGCGGUCAAUCAUGC	Chmp	[626-644]
					461	GGAUUUCAUCUGGUGUGAA	UUCACACCAGAUGAAAUCC	Chmp	[3092-3110]
462	UGGAAUUGGUAGCAAGGCA	UGCCUUGCUACCAAUUCCA	Chmp	[471-489]
					463	UAACAAUUUCUCAUACUUA	UAAGUAUGAGAAAUUGUUA	Chmp	[3774-3792]
464	GCACCAAAAAGGAGGUGGA	UCCACCUCCUUUUUGGUGC	Chmp	[1463-1481]
					465	AGAUCCUGGAUCUCUCAAA	UUUGAGAGAUCCAGGAUCU		[2354-2372]
466	CAAGUGUAUGGUCAAGACA	UGUCUUGACCAUACACUUG	Chmp	[1128-1146]
					467	AUAAAACUGACAUAGAGAA	UUCUCUAUGUCAGUUUUAU	Chmp	[3456-3474]
468	UGCGCCUGUCCAAGAAGAU	AUCUUCUUGGACAGGCGCA	大鼠，Ms，Chmp	[581-599]
					469	GGGAUGACCAGCAGAAAGU	ACUUUCUGCUGGUCAUCCC	Chmp	[407-425]
470	AACAGAUGCCGUCCAAGGA	UCCUUGGACGGCAUCUGUU	Chmp	[1976-1994]

471	CUAUGAGAAGCUCAAAACU	AGUUUUGAGCUUCUCAUAG	大鼠，Chmp	[2550-2568]
					472	AAAGAAAAAGACAAGGAUA	UAUCCUUGUCUUUUUCUUU	Chmp	[847-865]
473	AGCUUUCCUUCUCCAGGAA	UUCCUGGAGAAGGAAAGCU	Chmp	[3804-3822]
					474	UGGUGUAGACGUUCCUCUU	AAGAGGAACGUCUACACCA		[3066-3084]
475	AAGCACGCUUCACAUAUCA	UGAUAUGUGAAGCGUGCUU	Chmp	[2968-2986]
					476	AAUUUCUCAUACUUAGAAA	UUUCUAAGUAUGAGAAAUU	Chmp	[3778-3796]
477	UGGGUGACUUUGCAGCAGA	UCUGCUGCAAAGUCACCCA	Chmp	[500-518]
					478	AGUCAAGAGUGAAGGAAAG	CUUUCCUUCACUCUUGACU	大鼠，Chmp	[774-792]
479	UGACUUUGCAGCAGAGUAU	AUACUCUGCUGCAAAGUCA	Chmp	[504-522]
					480	UAAAAAACAGGACCGUAUA	UAUACGGUCCUGUUUUUUA		[1221-1239]
481	AUGACCAGCAGAAAGUCAA	UUGACUUUCUGCUGGUCAU	Chmp	[410-428]
					482	ACGCUUCACAUAUCAGCAA	UUGCUGAUAUGUGAAGCGU	Chmp	[2972-2990]
483	UGGUGGAGUAUGAGAUCGA	UCGAUCUCAUACUCCACCA	Chmp	[2228-2246]
					484	UGUCCAAGAAGAUGGUGGA	UCCACCAUCUUCUUGGACA	Ms	[587-605]
485	CUUGGGACCGGGAUUUCAU	AUGAAAUCCCGGUCCCAAG	Chmp	[3082-3100]
					486	UGUGAAUGACACCUCUCUA	UAGAGAGGUGUCAUUCACA	Chmp	[3105-3123]
487	ACAUGAAGAUCCUGACUCU	AGAGUCAGGAUCUUCAUGU	大鼠，Ms，Chmp	[1346-1364]
					488	CUUUAAGAUAGAGCGUGAA	UUCACGCUCUAUCUUAAAG	Chmp	[2679-2697]
489	AUACUUAGAAACAAAAAGA	UCUUUUUGUUUCUAAGUAU	Chmp	[3786-3804]
					490	UGUAUGGAGAAGAUAGAAA	UUUCUAUCUUCUCCAUACA	Chmp	[553-571]
491	CAUCGAUGUCAACUAUGAG	CUCAUAGUUGACAUCGAUG	大鼠，Chmp	[2538-2556]
					492	CGAUAUCUUUAAGAUAGAG	CUCUAUCUUAAAGAUAUCG		[2673-2691]
493	AGGUGGAUGGGUUCUCUGA	UCAGAGAACCCAUCCACCU	Chmp	[380-398]
					494	AUAAAGAAGCCCUGAAGAA	UUCUUCAGGGCUUCUUUAU	Chmp	[743-761]
495	CCAGCAGAAAGUCAAGAAG	CUUCUUGACUUUCUGCUGG	Chmp	[414-432]
					496	CAUCAAGAUGAUCUUUGAU	AUCAAAGAUCAUCUUGAUG	Chmp	[2187-2205]
497	AAAUCUCUUACCUCAAGAA	UUCUUGAGGUAAGAGAUUU	Chmp	[1193-1211]

498	ACUGAAGCACGCUUCACAU	AUGUGAAGCGUGCUUCAGU	Chmp	[2964-2982]
					499	GAGGACGACAAGGAAAACA	UGUUUUCCUUGUCGUCCUC	Chmp	[1897-1915]
500	UCAUGAAAUUAUAUGAAGA	UCUUCAUAUAAUUUCAUGA	Chmp	[2012-2030]

表B 26RAC1-ras-相关的C3肉毒菌毒素底物1

表B 27SHC1-SHC转化蛋白1

表B 28SLC2A1-溶质载体家族2，成员1

No.	正义链siRNA	反义链siRNA	其他Sp	人-5730050：180-1658
					1	CCAAGAGUGUGCUAAAGAA	UUCUUUAGCACACUCUUGG		[850-868]
2	AGAUGAUGCGGGAGAAGAA	UUCUUCUCCCGCAUCAUCU	大鼠，Ms	[928-946]
					3	CCACGAGCAUCUUCGAGAA	UUCUCGAAGAUGCUCGUGG		[1060-1078]
4	GAUAGUUGGUGUUCAAAAA	UUUUUGAACACCAACUAUC		[2772-2790]
					5	GCUGGAUGAGACUUCCAAA	UUUGGAAGUCUCAUCCAGC		[1724-1742]
6	CAAGCAACAGGUUUUAUAA	UUAUAAAACCUGUUGCUUG		[1874-1892]
					7	GGAUGGGAGUGAGACAGAA	UUCUGUCUCACUCCCAUCC		[2584-2602]
8	CAAAGUUCCUGAGACUAAA	UUUAGUCUCAGGAACUUUG		[1529-1547]
					9	GGCUGAUUCCCAAGUGUGA	UCACACUUGGGAAUCAGCC		[1640-1658]
10	GCUCCAGGAUUUUAACAAA	UUUGUUAAAAUCCUGGAGC		[1826-1844]

11	GAUGCAAGAUAUUUAUAUA	UAUAUAAAUAUCUUGCAUC		[2399-2417]
					12	CAAACUCACUGCUCAAGAA	UUCUUGAGCAGUGAGUUUG		[2350-2368]
13	UCUUUAUCUUGACAUUCAA	UUGAAUGUCAAGAUAAAGA		[2733-2751]
					14	GCAUUAUUUUGAAUGUGAA	UUCACAUUCAAAAUAAUGC		[2833-2851]
15	AAGCAAGACUGUUGCUCAA	UUGAGCAACAGUCUUGCUU		[1844-1862]
					16	GGGAGAAGAAGGUCACCAU	AUGGUGACCUUCUUCUCCC	大鼠，Ms	[937-955]
17	CGUGAUGCUCAGGCUUGAA	UUCAAGCCUGAGCAUCACG		[2811-2829]
					18	AGGUGAUCGAGGAGUUCUA	UAGAACUCCUCGAUCACCU		[292-310]
19	UUAGAAACAUGGUUUUGAA	UUCAAAACCAUGUUUCUAA		[2537-2555]
					20	CCAUCAUGGGCAACAAGGA	UCCUUGUUGCCCAUGAUGG		[712-730]
21	GGGAGUGAGACAGAAGUAA	UUACUUCUGUCUCACUCCC		[2588-2606]
					22	GUGUCCUCUUGCUCAAAAA	UUUUUGAGCAAGAGGACAC		[2678-2696]
23	GACUGUUGCUCAAAUCUAU	AUAGAUUUGAGCAACAGUC		[1850-1868]
					24	CGGCGGAAUUCAAUGCUGA	UCAGCAUUGAAUUCCGCCG		[453-471]
25	CUACAAAGCUUCUAUCCCA	UGGGAUAGAAGCUUUGUAG		[2081-2099]
					26	GUGUAUAGAUGCAAGAUAU	AUAUCUUGCAUCUAUACAC		[2392-2410]
27	UUUGGUUGUCAAUAUUAAA	UUUAAUAUUGACAACCAAA		[2422-2440]
					28	AAGAGAGUCGGCAGAUGAU	AUCAUCUGCCGACUCUCUU		[916-934]
29	UUACCUAAACAGAUAUAAA	UUUAUAUCUGUUUAGGUAA		[2508-2526]
					30	GACACUAAGUUAUAGUAUA	UAUACUAUAACUUAGUGUC	大鼠，Ms	[2445-2463]
31	UGCUGAGCAUCAUCUUCAU	AUGAAGAUGAUGCUCAGCA		[745-763]
					32	CCCUGGAUGUCCUAUCUGA	UCAGAUAGGACAUCCAGGG	大鼠	[1263-1281]
33	GAGGAGUUCUACAACCAGA	UCUGGUUGUAGAACUCCUC		[300-318]
					34	CUCCAGGAUUUUAACAAAA	UUUUGUUAAAAUCCUGGAG		[1827-1845]
35	GAGUGAGACAGAAGUAAGU	ACUUACUUCUGUCUCACUC		[2590-2608]
					36	CCCUGUUACCCAGAGAAUA	UAUUCUCUGGGUAACAGGG		[2707-2725]
37	ACUCCAUCAUGGGCAACAA	UUGUUGCCCAUGAUGGAGU		[709-727]

38	GGCGGAAUUCAAUGCUGAU	AUCAGCAUUGAAUUCCGCC		[454-472]
					39	GAAGAGAGUCGGCAGAUGA	UCAUCUGCCGACUCUCUUC		[915-933]
40	GGAGAUGAAGGAAGAGAGU	ACUCUCUUCCUUCAUCUCC		[905-923]
					41	CUGCAAACUCACUGCUCAA	UUGAGCAGUGAGUUUGCAG		[2347-2365]
42	AGGAUUUUAACAAAAGCAA	UUGCUUUUGUUAAAAUCCU		[1831-1849]
					43	AACUGGACCUCAAAUUUCA	UGAAAUUUGAGGUCCAGUU		[1410-1428]
44	AUUCAAUGCUGAUGAUGAA	UUCAUCAUCAGCAUUGAAU		[460-478]
					45	GUCCCUACGUCUUCAUCAU	AUGAUGAAGACGUAGGGAC		[1468-1486]
46	CACACUAAUCGAACUAUGA	UCAUAGUUCGAUUAGUGUG		[2061-2079]
					47	AUCGAACUAUGAACUACAA	UUGUAGUUCAUAGUUCGAU		[2068-2086]
48	CCCUAAGGAUCUCUCAGGA	UCCUGAGAGAUCCUUAGGG		[1696-1714]
					49	GCAAUGAUGUCCAGAAGAA	UUCUUCUGGACAUCAUUGC		[1791-1809]
50	UCUCCAACUGGACCUCAAA	UUUGAGGUCCAGUUGGAGA	Ms	[1405-1423]
					51	ACACUAAUCGAACUAUGAA	UUCAUAGUUCGAUUAGUGU		[2062-2080]
52	CUGUGGGCCUUUUCGUUAA	UUAACGAAAAGGCCCACAG		[424-442]
					53	CAUCUUCACCUACUUCAAA	UUUGAAGUAGGUGAAGAUG	大鼠，Ms	[1514-1532]
54	GCAUCAACGCUGUCUUCUA	UAGAAGACAGCGUUGAUGC		[1036-1054]
					55	UCAUCUUCACCUACUUCAA	UUGAAGUAGGUGAAGAUGA	大鼠，Ms	[1513-1531]
56	ACCCAACCACUCAAAUUAA	UUAAUUUGAGUGGUUGGGU		[2192-2210]
					57	GGCUGGACCUAUGUCCUAA	UUAGGACAUAGGUCCAGCC		[2039-2057]
58	GGUUUGGAUGGGAGUGAGA	UCUCACUCCCAUCCAAACC		[2579-2597]
					59	UGUCAAUAUUAAAUACAGA	UCUGUAUUUAAUAUUGACA	Ms	[2428-2446]
60	GAAAUCGCAUUAUUUUGAA	UUCAAAAUAAUGCGAUUUC		[2827-2845]
					61	GCAAGACUGUUGCUCAAAU	AUUUGAGCAACAGUCUUGC		[1846-1864]
62	CCUUCUUCACCCAGCUAAU	AUUAGCUGGGUGAAGAAGG		[2014-2032]
					63	CCACACUAUUACCAUGAGA	UCUCAUGGUAAUAGUGUGG		[2311-2329]
64	UUUGAUAGUUGGUGUUCAA	UUGAACACCAACUAUCAAA		[2769-2787]

65	UUUUGGUUGUCAAUAUUAA	UUAAUAUUGACAACCAAAA		[2421-2439]
					66	GAUUUUAACAAAAGCAAGA	UCUUGCUUUUGUUAAAAUC		[1833-1851]
67	CACACUAUUACCAUGAGAA	UUCUCAUGGUAAUAGUGUG		[2312-2330]
					68	GUAUGUGGGUGAAGUGUCA	UGACACUUCACCCACAUAC		[605-623]
69	UGGACUCCAUCAUGGGCAA	UUGCCCAUGAUGGAGUCCA		[706-724]
					70	AACGGCUCCAGGAUUUUAA	UUAAAAUCCUGGAGCCGUU		[1822-1840]
71	CAGGAUUUUAACAAAAGCA	UGCUUUUGUUAAAAUCCUG		[1830-1848]
					72	GCAUGUGCUUCCAGUAUGU	ACAUACUGGAAGCACAUGC	Ms	[1435-1453]
73	CCUGUUACCCAGAGAAUAU	AUAUUCUCUGGGUAACAGG		[2708-2726]
					74	CCACCUCACUCCUGUUACU	AGUAACAGGAGUGAGGUGG		[2490-2508]
75	UGCAGGAGAUGAAGGAAGA	UCUUCCUUCAUCUCCUGCA		[901-919]
					76	UGAUCGAGGAGUUCUACAA	UUGUAGAACUCCUCGAUCA		[295-313]
77	UGUUCUUCAUCUUCACCUA	UAGGUGAAGAUGAAGAACA		[1507-1525]
					78	CCUGCAGGAGAUGAAGGAA	UUCCUUCAUCUCCUGCAGG		[899-917]
79	GCUCAAGAAGACAUGGAGA	UCUCCAUGUCUUCUUGAGC		[2360-2378]
					80	UGAUAGUUGGUGUUCAAAA	UUUUGAACACCAACUAUCA		[2771-2789]
81	CAGACACUAAGUUAUAGUA	UACUAUAACUUAGUGUCUG	大鼠，Ms	[2443-2461]
					82	CGGCUUAGACUUCGACUCA	UGAGUCGAAGUCUAAGCCG		[2628-2646]
83	UAGUUGGUGUUCAAAAAAA	UUUUUUUGAACACCAACUA		[2774-2792]
					84	AAGGCAUUUCUAUCACAUA	UAUGUGAUAGAAAUGCCUU		[2750-2768]
85	GAAGAAUAUUCAGGACUUA	UAAGUCCUGAAUAUUCUUC		[1804-1822]
					86	ACUGGACCUCAAAUUUCAU	AUGAAAUUUGAGGUCCAGU		[1411-1429]
87	UGGGAGUGAGACAGAAGUA	UACUUCUGUCUCACUCCCA		[2587-2605]
					88	GGAUGAGACUUCCAAACCU	AGGUUUGGAAGUCUCAUCC		[1727-1745]
89	GGCUUGAAAUCGCAUUAUU	AAUAAUGCGAUUUCAAGCC		[2822-2840]
					90	GGAAUUCAAUGCUGAUGAU	AUCAUCAGCAUUGAAUUCC		[457-475]
91	CCCAACCACUCAAAUUAAU	AUUAAUUUGAGUGGUUGGG		[2193-2211]

92	GGUCCCUACGUCUUCAUCA	UGAUGAAGACGUAGGGACC		[1467-1485]
					93	GUUCUGUUCUUCAUCUUCA	UGAAGAUGAAGAACAGAAC		[1503-1521]
94	CCAACUUGUAAAUACACCA	UGGUGUAUUUACAAGUUGG		[2474-2492]
					95	GACAUUCAAGGCAUUUCUA	UAGAAAUGCCUUGAAUGUC		[2743-2761]
96	GGAGUUCUACAACCAGACA	UGUCUGGUUGUAGAACUCC		[302-320]
					97	AUAUAUUUUUGGUUGUCAA	UUGACAACCAAAAAUAUAU		[2415-2433]
98	CCUACGUCUUCAUCAUCUU	AAGAUGAUGAAGACGUAGG	大鼠，Ms	[1471-1489]
					99	CAAAUUUCAUUGUGGGCAU	AUGCCCACAAUGAAAUUUG		[1420-1438]
100	GUUUGAUCCCUGUUACCCA	UGGGUAACAGGGAUCAAAC		[2700-2718]
					101	GCUCAAAUCUAUUCAGACA	UGUCUGAAUAGAUUUGAGC		[1857-1875]
102	CAGCCCUAAGGAUCUCUCA	UGAGAGAUCCUUAGGGCUG		[1693-1711]
					103	UAGAAACAUGGUUUUGAAA	UUUCAAAACCAUGUUUCUA		[2538-2556]
104	GGAUUUUAACAAAAGCAAG	CUUGCUUUUGUUAAAAUCC		[1832-1850]
					105	CAAUGAUGUCCAGAAGAAU	AUUCUUCUGGACAUCAUUG		[1792-1810]
106	UGCUCAUGGGCUUCUCGAA	UUCGAGAAGCCCAUGAGCA		[502-520]
					107	GGUUCUAGUCUCCUUUGCA	UGCAAAGGAGACUAGAACC		[2285-2303]
108	GUUGGUGUUCAAAAAAACA	UGUUUUUUUGAACACCAAC		[2776-2794]
					109	AGGCAUUUCUAUCACAUAU	AUAUGUGAUAGAAAUGCCU		[2751-2769]
110	CCUGUUACUUACCUAAACA	UGUUUAGGUAAGUAACAGG		[2500-2518]
					111	GCUUGAAAUCGCAUUAUUU	AAAUAAUGCGAUUUCAAGC		[2823-2841]
112	ACAACACUGGAGUCAUCAA	UUGAUGACUCCAGUGUUGU		[262-280]
					113	CCCAGAGAAUAUAUACAUU	AAUGUAUAUAUUCUCUGGG		[2715-2733]
114	CUCCUGUUACUUACCUAAA	UUUAGGUAAGUAACAGGAG		[2498-2516]
					115	GAGGGUAGGAGGUUUGGAU	AUCCAAACCUCCUACCCUC		[2569-2587]
116	CACUCAAAUUAAUCUUUCU	AGAAAGAUUAAUUUGAGUG		[2199-2217]
					117	GGCUGGUUUUUAGAAACAU	AUGUUUCUAAAAACCAGCC		[2528-2546]
118	GCUCAUGGGCUUCUCGAAA	UUUCGAGAAGCCCAUGAGC		[503-521]

119	GAGACACUUGCCUUCUUCA	UGAAGAAGGCAAGUGUCUC		[2004-2022]
					120	CAGAUGAUGCGGGAGAAGA	UCUUCUCCCGCAUCAUCUG	大鼠，Ms	[927-945]
121	CAGGAUCCAGUCCCUUACA	UGUAAGGGACUGGAUCCUG		[2645-2663]
					122	CUGGGCAAGUCCUUUGAGA	UCUCAAAGGACUUGCCCAG	大鼠，Ms	[522-540]
123	AGCUGGAUGAGACUUCCAA	UUGGAAGUCUCAUCCAGCU		[1723-1741]
					124	CACUCCUGUUACUUACCUA	UAGGUAAGUAACAGGAGUG		[2496-2514]
125	CAUCAACGCUGUCUUCUAU	AUAGAAGACAGCGUUGAUG		[1037-1055]
					126	AUAGAUGCAAGAUAUUUAU	AUAAAUAUCUUGCAUCUAU		[2396-2414]
127	UGGGCAUGUGCUUCCAGUA	UACUGGAAGCACAUGCCCA	Ms	[1432-1450]
					128	CAAGGCAUUUCUAUCACAU	AUGUGAUAGAAAUGCCUUG		[2749-2767]
129	CGCAUUAUUUUGAAUGUGA	UCACAUUCAAAAUAAUGCG		[2832-2850]
					130	GGCUCCAGGAUUUUAACAA	UUGUUAAAAUCCUGGAGCC		[1825-1843]
131	UGAUGCUCAGGCUUGAAAU	AUUUCAAGCCUGAGCAUCA		[2813-2831]
					132	CUGUUACCCAGAGAAUAUA	UAUAUUCUCUGGGUAACAG		[2709-2727]
133	ACUCCACGAGCAUCUUCGA	UCGAAGAUGCUCGUGGAGU		[1057-1075]
					134	UAUUAAAUACAGACACUAA	UUAGUGUCUGUAUUUAAUA	大鼠，Ms	[2434-2452]
135	CCAGCAAUGAUGUCCAGAA	UUCUGGACAUCAUUGCUGG		[1788-1806]
					136	CAAAGCUUCUAUCCCAGGA	UCCUGGGAUAGAAGCUUUG		[2084-2102]
137	UAUAGAUGCAAGAUAUUUA	UAAAUAUCUUGCAUCUAUA		[2395-2413]
					138	CGGCUCCAGGAUUUUAACA	UGUUAAAAUCCUGGAGCCG		[1824-1842]
139	CAGGCUUGAAAUCGCAUUA	UAAUGCGAUUUCAAGCCUG		[2820-2838]
					140	GCUCAGGCUUGAAAUCGCA	UGCGAUUUCAAGCCUGAGC		[2817-2835]
141	CAGUGUCCUCUUGCUCAAA	UUUGAGCAAGAGGACACUG		[2676-2694]
					142	GCUCAAAAAUCUGUUUGAU	AUCAAACAGAUUUUUGAGC		[2688-2706]
143	GCAACGGCUUAGACUUCGA	UCGAAGUCUAAGCCGUUGC		[2624-2642]
					144	GUGAUGCUCAGGCUUGAAA	UUUCAAGCCUGAGCAUCAC		[2812-2830]
145	CGAGGAGUUCUACAACCAG	CUGGUUGUAGAACUCCUCG		[299-317]

146	CUCAAAUCUAUUCAGACAA	UUGUCUGAAUAGAUUUGAG		[1858-1876]
					147	GAUCCCUGUUACCCAGAGA	UCUCUGGGUAACAGGGAUC		[2704-2722]
148	CCUGGAUGUCCUAUCUGAG	CUCAGAUAGGACAUCCAGG	大鼠	[1264-1282]
					149	GCUUCUCGAAACUGGGCAA	UUGCCCAGUUUCGAGAAGC		[511-529]
150	UGGUUGUCAAUAUUAAAUA	UAUUUAAUAUUGACAACCA	Ms	[2424-2442]
					151	GGUUGUCAAUAUUAAAUAC	GUAUUUAAUAUUGACAACC	Ms	[2425-2443]
152	ACAUGGUUUUGAAAUGCUU	AAGCAUUUCAAAACCAUGU		[2543-2561]
					153	UACCUAAACAGAUAUAAAU	AUUUAUAUCUGUUUAGGUA		[2509-2527]
154	UCGAACUAUGAACUACAAA	UUUGUAGUUCAUAGUUCGA		[2069-2087]
					155	CAUUCUUUAUCUUGACAUU	AAUGUCAAGAUAAAGAAUG		[2730-2748]
156	GGGCAUGUGCUUCCAGUAU	AUACUGGAAGCACAUGCCC	Ms	[1433-1451]
					157	CCUUACACGUACCUCUCAU	AUGAGAGGUACGUGUAAGG		[2657-2675]
158	AAUCGAACUAUGAACUACA	UGUAGUUCAUAGUUCGAUU		[2067-2085]
					159	AGAAGGUCACCAUCCUGGA	UCCAGGAUGGUGACCUUCU		[943-961]
160	GGAGUGAGACAGAAGUAAG	CUUACUUCUGUCUCACUCC		[2589-2607]
					161	CAACCACUGCAACGGCUUA	UAAGCCGUUGCAGUGGUUG		[2616-2634]
162	CCUGCAAACUCACUGCUCA	UGAGCAGUGAGUUUGCAGG		[2346-2364]
					163	CUUACCUAAACAGAUAUAA	UUAUAUCUGUUUAGGUAAG		[2507-2525]
164	GGAUGUCCUAUCUGAGCAU	AUGCUCAGAUAGGACAUCC	Ms	[1267-1285]
					165	GGUGUUCAAAAAAACACUA	UAGUGUUUUUUUGAACACC		[2779-2797]
166	CACUAUUACCAUGAGAAGA	UCUUCUCAUGGUAAUAGUG		[2314-2332]
					167	AAUCUAUUCAGACAAGCAA	UUGCUUGUCUGAAUAGAUU		[1862-1880]
168	UCAGUGUCCUCUUGCUCAA	UUGAGCAAGAGGACACUGA		[2675-2693]
					169	CGAACUAUGAACUACAAAG	CUUUGUAGUUCAUAGUUCG		[2070-2088]
170	GUUACUUACCUAAACAGAU	AUCUGUUUAGGUAAGUAAC		[2503-2521]
					171	AGACUGUUGCUCAAAUCUA	UAGAUUUGAGCAACAGUCU		[1849-1867]
172	GCCCAUGUAUGUGGGUGAA	UUCACCCACAUACAUGGGC		[599-617]

173	UUACUUACCUAAACAGAUA	UAUCUGUUUAGGUAAGUAA		[2504-2522]
					174	AUAGUUGGUGUUCAAAAAA	UUUUUUGAACACCAACUAU		[2773-2791]
175	AAGGAAGAGAGUCGGCAGA	UCUGCCGACUCUCUUCCUU		[912-930]
					176	AGAAGAAGGUCACCAUCCU	AGGAUGGUGACCUUCUUCU		[940-958]
177	GAGACUUCCAAACCUGACA	UGUCAGGUUUGGAAGUCUC		[1731-1749]
					178	UUCUCCAACUGGACCUCAA	UUGAGGUCCAGUUGGAGAA	Ms	[1404-1422]
179	CCAACUGGACCUCAAAUUU	AAAUUUGAGGUCCAGUUGG		[1408-1426]
					180	AAGUUAUAGUAUAUCUGGA	UCCAGAUAUACUAUAACUU	Ms	[2451-2469]
181	GUUUUGAAAUGCUUGUGGA	UCCACAAGCAUUUCAAAAC		[2548-2566]
					182	ACACUAAGUUAUAGUAUAU	AUAUACUAUAACUUAGUGU	大鼠，Ms	[2446-2464]
183	CAGCUGGAUGAGACUUCCA	UGGAAGUCUCAUCCAGCUG		[1722-1740]
					184	GCUAAUCUGUAGGGCUGGA	UCCAGCCCUACAGAUUAGC	大鼠，Ms	[2027-2045]
185	ACUCCUGUUACUUACCUAA	UUAGGUAAGUAACAGGAGU		[2497-2515]
					186	GGACCUCAAAUUUCAUUGU	ACAAUGAAAUUUGAGGUCC		[1414-1432]
187	UCCUGGUUCUGUUCUUCAU	AUGAAGAACAGAACCAGGA		[1498-1516]
					188	CAAUGCUGAUGAUGAACCU	AGGUUCAUCAUCAGCAUUG		[463-481]
189	CUUCCAGUAUGUGGAGCAA	UUGCUCCACAUACUGGAAG	Ms	[1442-1460]
					190	ACACGUACCUCUCAUCAGU	ACUGAUGAGAGGUACGUGU		[2661-2679]
191	AAUGAUGUCCAGAAGAAUA	UAUUCUUCUGGACAUCAUU		[1793-1811]
					192	GACCUAUGUCCUAAGGACA	UGUCCUUAGGACAUAGGUC		[2044-2062]
193	UCAUCAACCGCAACGAGGA	UCCUCGUUGCGGUUGAUGA		[823-841]
					194	CAGAGAAUAUAUACAUUCU	AGAAUGUAUAUAUUCUCUG		[2717-2735]
195	AUACAGACACUAAGUUAUA	UAUAACUUAGUGUCUGUAU	大鼠，Ms	[2440-2458]
					196	AGACAAGCAACAGGUUUUA	UAAAACCUGUUGCUUGUCU		[1871-1889]
197	UGUGGUCCCUACGUCUUCA	UGAAGACGUAGGGACCACA		[1464-1482]
					198	GGAGAAGAAGGUCACCAUC	GAUGGUGACCUUCUUCUCC	大鼠，Ms	[938-956]
199	CCCUUACACGUACCUCUCA	UGAGAGGUACGUGUAAGGG		[2656-2674]

200	AAGAAUAUUCAGGACUUAA	UUAAGUCCUGAAUAUUCUU		[1805-1823]
					201	GGCCUUCUUUGAAGUGGGU	ACCCACUUCAAAGAAGGCC		[1307-1325]
202	AGAAGGUGAUCGAGGAGUU	AACUCCUCGAUCACCUUCU		[289-307]
					203	GUUACCCAGAGAAUAUAUA	UAUAUAUUCUCUGGGUAAC		[2711-2729]
204	AUGACCUGCAGGAGAUGAA	UUCAUCUCCUGCAGGUCAU		[895-913]
					205	CUGUCGUGUCGCUGUUUGU	ACAAACAGCGACACGACAG		[1141-1159]
206	GGUCAGGCUCCAUUAGGAU	AUCCUAAUGGAGCCUGACC		[2151-2169]
					207	CGAAACUGGGCAAGUCCUU	AAGGACUUGCCCAGUUUCG		[517-535]
208	GGUUUUUAGAAACAUGGUU	AACCAUGUUUCUAAAAACC		[2532-2550]
					209	GUGAUAAGACACCCGAGGA	UCCUCGGGUGUCUUAUCAC		[1603-1621]
210	GGACCUAUGUCCUAAGGAC	GUCCUUAGGACAUAGGUCC		[2043-2061]
					211	GUAAAUACACCACCUCACU	AGUGAGGUGGUGUAUUUAC		[2481-2499]
212	AAUCUUUCUUUACCUGAGA	UCUCAGGUAAAGAAAGAUU		[2209-2227]
					213	CGGAAUUCAAUGCUGAUGA	UCAUCAGCAUUGAAUUCCG		[456-474]
214	ACGUCUUCAUCAUCUUCAC	GUGAAGAUGAUGAAGACGU	大鼠，Ms	[1474-1492]
					215	CAAGAGUGUGCUAAAGAAG	CUUCUUUAGCACACUCUUG		[851-869]
216	UCCUGCUCAUCAACCGCAA	UUGCGGUUGAUGAGCAGGA		[817-835]
					217	AGUGUCCUCUUGCUCAAAA	UUUUGAGCAAGAGGACACU		[2677-2695]
218	CAACAGGUUUUAUAAUUUU	AAAAUUAUAAAACCUGUUG		[1878-1896]
					219	UGUAUAGAUGCAAGAUAUU	AAUAUCUUGCAUCUAUACA		[2393-2411]
220	ACAAGCAACAGGUUUUAUA	UAUAAAACCUGUUGCUUGU		[1873-1891]
					221	UGCUCAAAAAUCUGUUUGA	UCAAACAGAUUUUUGAGCA		[2687-2705]
222	UUUGGAUGGGAGUGAGACA	UGUCUCACUCCCAUCCAAA		[2581-2599]
					223	CAACACUGGAGUCAUCAAU	AUUGAUGACUCCAGUGUUG		[263-281]
224	GCUGGUUUUUAGAAACAUG	CAUGUUUCUAAAAACCAGC		[2529-2547]
					225	CUCCAACUGGACCUCAAAU	AUUUGAGGUCCAGUUGGAG		[1406-1424]
226	UGCUGAUGAUGAACCUGCU	AGCAGGUUCAUCAUCAGCA		[466-484]

227	GUGAUCGAGGAGUUCUACA	UGUAGAACUCCUCGAUCAC		[294-312]
					228	CUAAUCGAACUAUGAACUA	UAGUUCAUAGUUCGAUUAG		[2065-2083]
229	GCAAACUCACUGCUCAAGA	UCUUGAGCAGUGAGUUUGC		[2349-2367]
					230	CUGUGCUCCUGGUUCUGUU	AACAGAACCAGGAGCACAG		[1492-1510]
231	UCACCAUCCUGGAGCUGUU	AACAGCUCCAGGAUGGUGA		[949-967]
					232	GUUGCAGGCUUCUCCAACU	AGUUGGAGAAGCCUGCAAC		[1395-1413]
233	AAAGCAAGACUGUUGCUCA	UGAGCAACAGUCUUGCUUU	大鼠	[1843-1861]
					234	GCUGUCUUCUAUUACUCCA	UGGAGUAAUAGAAGACAGC		[1044-1062]
235	AGUUGGUGUUCAAAAAAAC	GUUUUUUUGAACACCAACU		[2775-2793]
					236	CCAGGAUUUUAACAAAAGC	GCUUUUGUUAAAAUCCUGG		[1829-1847]
237	AAGCAACAGGUUUUAUAAU	AUUAUAAAACCUGUUGCUU		[1875-1893]
					238	UGAAAUGCUUGUGGAUUGA	UCAAUCCACAAGCAUUUCA		[2552-2570]
239	GCCUUCUUCACCCAGCUAA	UUAGCUGGGUGAAGAAGGC		[2013-2031]
					240	ACCUCACUCCUGUUACUUA	UAAGUAACAGGAGUGAGGU		[2492-2510]
241	AGUCCUUUGAGAUGCUGAU	AUCAGCAUCUCAAAGGACU	大鼠，Ms	[529-547]
					242	GCAUUUCUAUCACAUAUUU	AAAUAUGUGAUAGAAAUGC		[2753-2771]
243	UGGGCAAGUCCUUUGAGAU	AUCUCAAAGGACUUGCCCA	大鼠，Ms	[523-541]
					244	UAGAUGCAAGAUAUUUAUA	UAUAAAUAUCUUGCAUCUA		[2397-2415]
245	UCUUGACAUUCAAGGCAUU	AAUGCCUUGAAUGUCAAGA		[2739-2757]
					246	UGGAUGGGAGUGAGACAGA	UCUGUCUCACUCCCAUCCA		[2583-2601]
247	UCUUCAUCUUCACCUACUU	AAGUAGGUGAAGAUGAAGA	大鼠，Ms	[1510-1528]
					248	CCUUUGAGAUGCUGAUCCU	AGGAUCAGCAUCUCAAAGG	大鼠，Ms	[532-550]
249	UACCCAGAGAAUAUAUACA	UGUAUAUAUUCUCUGGGUA		[2713-2731]
					250	AGACUAAGCCCUGUCGAGA	UCUCGACAGGGCUUAGUCU		[1989-2007]
251	CAGGAGAUGAAGGAAGAGA	UCUCUUCCUUCAUCUCCUG		[903-921]
					252	UCGAGGAGUUCUACAACCA	UGGUUGUAGAACUCCUCGA		[298-316]
253	AGGAGAUGAAGGAAGAGAG	CUCUCUUCCUUCAUCUCCU		[904-922]

254	CCUCACUCCUGUUACUUAC	GUAAGUAACAGGAGUGAGG		[2493-2511]
					255	GCUUCGUGCCCAUGUAUGU	ACAUACAUGGGCACGAAGC		[592-610]
256	UCAAAGUUCCUGAGACUAA	UUAGUCUCAGGAACUUUGA		[1528-1546]
					257	GUGGUCCCUACGUCUUCAU	AUGAAGACGUAGGGACCAC		[1465-1483]
258	AGAUGCAAGAUAUUUAUAU	AUAUAAAUAUCUUGCAUCU		[2398-2416]
					259	AGAGUGUGCUAAAGAAGCU	AGCUUCUUUAGCACACUCU		[853-871]
260	GCCUUUUCGUUAACCGCUU	AAGCGGUUAACGAAAAGGC		[430-448]
					261	GCAGGAGAUGAAGGAAGAG	CUCUUCCUUCAUCUCCUGC		[902-920]
262	ACCCAGAGAAUAUAUACAU	AUGUAUAUAUUCUCUGGGU		[2714-2732]
					263	GCUUGUGGAUUGAGGGUAG	CUACCCUCAAUCCACAAGC		[2558-2576]
264	AGGCUUCGUGCCCAUGUAU	AUACAUGGGCACGAAGCCU		[590-608]
					265	GAGAAUAUAUACAUUCUUU	AAAGAAUGUAUAUAUUCUC		[2719-2737]
266	AGCAAGACUGUUGCUCAAA	UUUGAGCAACAGUCUUGCU		[1845-1863]
					267	CCCAUCUCUUCCUACCCAA	UUGGGUAGGAAGAGAUGGG		[2179-2197]
268	CAGCAAUGAUGUCCAGAAG	CUUCUGGACAUCAUUGCUG		[1789-1807]
					269	UGGUUUUUAGAAACAUGGU	ACCAUGUUUCUAAAAACCA		[2531-2549]
270	UCAAGGCAUUUCUAUCACA	UGUGAUAGAAAUGCCUUGA		[2748-2766]
					271	GCAACAGGUUUUAUAAUUU	AAAUUAUAAAACCUGUUGC		[1877-1895]
272	CCUACCCAACCACUCAAAU	AUUUGAGUGGUUGGGUAGG		[2189-2207]
					273	UGUCGCUGUUUGUGGUGGA	UCCACCACAAACAGCGACA		[1147-1165]
274	GACUUAACGGCUCCAGGAU	AUCCUGGAGCCGUUAAGUC		[1817-1835]
					275	UAUUUUUGGUUGUCAAUAU	AUAUUGACAACCAAAAAUA		[2418-2436]
276	ACCUGCAGGAGAUGAAGGA	UCCUUCAUCUCCUGCAGGU		[898-916]
					277	AACUCACUGCUCAAGAAGA	UCUUCUUGAGCAGUGAGUU		[2352-2370]
278	GAUGAUGCGGGAGAAGAAG	CUUCUUCUCCCGCAUCAUC	大鼠，Ms	[929-947]
					279	UUCUGUUCUUCAUCUUCAC	GUGAAGAUGAAGAACAGAA		[1504-1522]
280	UGACAUUCAAGGCAUUUCU	AGAAAUGCCUUGAAUGUCA		[2742-2760]

281	UAAGGAUCUCUCAGGAGCA	UGCUCCUGAGAGAUCCUUA		[1699-1717]
					282	AAAUACAGACACUAAGUUA	UAACUUAGUGUCUGUAUUU	大鼠，Ms	[2438-2456]
283	CACUAAUCGAACUAUGAAC	GUUCAUAGUUCGAUUAGUG		[2063-2081]
					284	CUUGAAAUCGCAUUAUUUU	AAAAUAAUGCGAUUUCAAG		[2824-2842]
285	CUUAGACUUCGACUCAGGA	UCCUGAGUCGAAGUCUAAG		[2631-2649]
					286	UGUUACUUACCUAAACAGA	UCUGUUUAGGUAAGUAACA		[2502-2520]
287	UACCCAACCACUCAAAUUA	UAAUUUGAGUGGUUGGGUA		[2191-2209]
					288	AUCCCUGUUACCCAGAGAA	UUCUCUGGGUAACAGGGAU		[2705-2723]
289	CAGACAAGCAACAGGUUUU	AAAACCUGUUGCUUGUCUG		[1870-1888]
					290	UGAACUACAAAGCUUCUAU	AUAGAAGCUUUGUAGUUCA		[2077-2095]
291	CAACCACUCAAAUUAAUCU	AGAUUAAUUUGAGUGGUUG		[2195-2213]
					292	AAAUCUAUUCAGACAAGCA	UGCUUGUCUGAAUAGAUUU		[1861-1879]
293	UAUACAUUCUUUAUCUUGA	UCAAGAUAAAGAAUGUAUA		[2726-2744]
					294	ACGGCUCCAGGAUUUUAAC	GUUAAAAUCCUGGAGCCGU		[1823-1841]
295	GCAAGUCCUUUGAGAUGCU	AGCAUCUCAAAGGACUUGC	大鼠，Ms	[526-544]
					296	UCGAGACACUUGCCUUCUU	AAGAAGGCAAGUGUCUCGA		[2002-2020]
297	UGAGGGUAGGAGGUUUGGA	UCCAAACCUCCUACCCUCA		[2568-2586]
					298	CGUCUUCAUCAUCUUCACU	AGUGAAGAUGAUGAAGACG		[1475-1493]
299	CCUCAAAUUUCAUUGUGGG	CCCACAAUGAAAUUUGAGG		[1417-1435]
					300	UGGUUCUGUUCUUCAUCUU	AAGAUGAAGAACAGAACCA		[1501-1519]
301	CCUGAAUGGUUCCAUGCCU	AGGCAUGGAACCAUUCAGG		[1962-1980]
					302	CCAUGUAUGUGGGUGAAGU	ACUUCACCCACAUACAUGG		[601-619]
303	CCGGGUUCUAGUCUCCUUU	AAAGGAGACUAGAACCCGG		[2282-2300]
					304	ACUUACCUAAACAGAUAUA	UAUAUCUGUUUAGGUAAGU		[2506-2524]
305	GCUACAACACUGGAGUCAU	AUGACUCCAGUGUUGUAGC		[259-277]
					306	CAUUAUUUUGAAUGUGAAG	CUUCACAUUCAAAAUAAUG		[2834-2852]
307	CUCAGGAUCCAGUCCCUUA	UAAGGGACUGGAUCCUGAG		[2643-2661]

308	AUCUGUAGGGCUGGACCUA	UAGGUCCAGCCCUACAGAU	Ms	[2031-2049]
					309	CUUCCUACCCAACCACUCA	UGAGUGGUUGGGUAGGAAG	Ms	[2186-2204]
310	ACACUAUUACCAUGAGAAG	CUUCUCAUGGUAAUAGUGU		[2313-2331]
					311	CCAGCUAAUCUGUAGGGCU	AGCCCUACAGAUUAGCUGG		[2024-2042]
312	UCAACCGCAACGAGGAGAA	UUCUCCUCGUUGCGGUUGA		[826-844]
					313	GUAGGAGGUUUGGAUGGGA	UCCCAUCCAAACCUCCUAC		[2573-2591]
314	AGAAGAAUAUUCAGGACUU	AAGUCCUGAAUAUUCUUCU	大鼠	[1803-1821]
					315	GGCAUUUCUAUCACAUAUU	AAUAUGUGAUAGAAAUGCC		[2752-2770]
316	GAUCCAGUCCCUUACACGU	ACGUGUAAGGGACUGGAUC		[2648-2666]
					317	UGUGCUUCCAGUAUGUGGA	UCCACAUACUGGAAGCACA	Ms	[1438-1456]
318	UCAACGCUGUCUUCUAUUA	UAAUAGAAGACAGCGUUGA		[1039-1057]
					319	UGUCCAGAAGAAUAUUCAG	CUGAAUAUUCUUCUGGACA		[1798-1816]
320	UGUCCUCUUGCUCAAAAAU	AUUUUUGAGCAAGAGGACA		[2679-2697]
					321	GAUCGAGGAGUUCUACAAC	GUUGUAGAACUCCUCGAUC		[296-314]
322	UUCUAUUACUCCACGAGCA	UGCUCGUGGAGUAAUAGAA		[1050-1068]
					323	UGUUACCCAGAGAAUAUAU	AUAUAUUCUCUGGGUAACA		[2710-2728]
324	GGUGAUCGAGGAGUUCUAC	GUAGAACUCCUCGAUCACC		[293-311]
					325	ACUAAGCCCUGUCGAGACA	UGUCUCGACAGGGCUUAGU		[1991-2009]
326	AAGUGAUAAGACACCCGAG	CUCGGGUGUCUUAUCACUU		[1601-1619]
					327	GACUUCCAAACCUGACAGA	UCUGUCAGGUUUGGAAGUC		[1733-1751]
328	CUGUCGAGACACUUGCCUU	AAGGCAAGUGUCUCGACAG		[1999-2017]
					329	UCCCUGUUACCCAGAGAAU	AUUCUCUGGGUAACAGGGA		[2706-2724]
330	GCUGGACCUAUGUCCUAAG	CUUAGGACAUAGGUCCAGC		[2040-2058]
					331	CUCCAUCAUGGGCAACAAG	CUUGUUGCCCAUGAUGGAG		[710-728]
332	GAAACAUGGUUUUGAAAUG	CAUUUCAAAACCAUGUUUC		[2540-2558]
					333	CCUUUUCGUUAACCGCUUU	AAAGCGGUUAACGAAAAGG		[431-449]
334	ACUUGUAAAUACACCACCU	AGGUGGUGUAUUUACAAGU		[2477-2495]

335	AACGCUGUCUUCUAUUACU	AGUAAUAGAAGACAGCGUU		[1041-1059]
					336	CCCUACGUCUUCAUCAUCU	AGAUGAUGAAGACGUAGGG	大鼠，Ms	[1470-1488]
337	CACUGCAACGGCUUAGACU	AGUCUAAGCCGUUGCAGUG		[2620-2638]
					338	CUACCCAACCACUCAAAUU	AAUUUGAGUGGUUGGGUAG		[2190-2208]
339	UUGUCAAUAUUAAAUACAG	CUGUAUUUAAUAUUGACAA	Ms	[2427-2445]
					340	GACUUCGACUCAGGAUCCA	UGGAUCCUGAGUCGAAGUC		[2635-2653]
341	GUCUUCUAUUACUCCACGA	UCGUGGAGUAAUAGAAGAC		[1047-1065]
					342	CUGCUCAAGAAGACAUGGA	UCCAUGUCUUCUUGAGCAG		[2358-2376]
343	UGUAGGGCUGGACCUAUGU	ACAUAGGUCCAGCCCUACA		[2034-2052]
					344	AAUUAAUCUUUCUUUACCU	AGGUAAAGAAAGAUUAAUU		[2205-2223]
345	CUCACUGCUCAAGAAGACA	UGUCUUCUUGAGCAGUGAG		[2354-2372]
					346	UAACGGCUCCAGGAUUUUA	UAAAAUCCUGGAGCCGUUA		[1821-1839]
347	CUUCAAAGUUCCUGAGACU	AGUCUCAGGAACUUUGAAG		[1526-1544]
					348	GGCUUAGACUUCGACUCAG	CUGAGUCGAAGUCUAAGCC		[2629-2647]
349	AUUUCUAUCACAUAUUUGA	UCAAAUAUGUGAUAGAAAU		[2755-2773]
					350	CUGCUGAGCAUCAUCUUCA	UGAAGAUGAUGCUCAGCAG		[744-762]
351	CCUACUUCAAAGUUCCUGA	UCAGGAACUUUGAAGUAGG	大鼠	[1522-1540]
					352	CUCUCAUCAGUGUCCUCUU	AAGAGGACACUGAUGAGAG		[2669-2687]
353	UUGUAAAUACACCACCUCA	UGAGGUGGUGUAUUUACAA		[2479-2497]
					354	CAUGGUUUUGAAAUGCUUG	CAAGCAUUUCAAAACCAUG		[2544-2562]
355	CAGUAUGUGGAGCAACUGU	ACAGUUGCUCCACAUACUG	Ms	[1446-1464]
					356	CACCCUGAAUGGUUCCAUG	CAUGGAACCAUUCAGGGUG		[1959-1977]
357	ACCACUGCAACGGCUUAGA	UCUAAGCCGUUGCAGUGGU		[2618-2636]
					358	CCAUCCCAUGGUUCAUCGU	ACGAUGAACCAUGGGAUGG		[1333-1351]
359	AUGAGACUUCCAAACCUGA	UCAGGUUUGGAAGUCUCAU		[1729-1747]
					360	UCUUCAUCAUCUUCACUGU	ACAGUGAAGAUGAUGAAGA		[1477-1495]
361	GAUGGGAGUGAGACAGAAG	CUUCUGUCUCACUCCCAUC		[2585-2603]

362	GUUCAAAAAAACACUAGUU	AACUAGUGUUUUUUUGAAC		[2782-2800]
					363	AGGAAGAGAGUCGGCAGAU	AUCUGCCGACUCUCUUCCU		[913-931]
364	UGUUCAAAAAAACACUAGU	ACUAGUGUUUUUUUGAACA		[2781-2799]
					365	CAAGACUGUUGCUCAAAUC	GAUUUGAGCAACAGUCUUG		[1847-1865]
366	CGAGACACUUGCCUUCUUC	GAAGAAGGCAAGUGUCUCG		[2003-2021]
					367	CUGGUUCUGUUCUUCAUCU	AGAUGAAGAACAGAACCAG		[1500-1518]
368	AGCUACCCUGGAUGUCCUA	UAGGACAUCCAGGGUAGCU		[1258-1276]
					369	ACAUUCAAGGCAUUUCUAU	AUAGAAAUGCCUUGAAUGU		[2744-2762]
370	CUUUCUUUACCUGAGACCA	UGGUCUCAGGUAAAGAAAG		[2212-2230]
					371	CACCUACUUCAAAGUUCCU	AGGAACUUUGAAGUAGGUG	大鼠	[1520-1538]
372	AGAGAAUAUAUACAUUCUU	AAGAAUGUAUAUAUUCUCU		[2718-2736]
					373	UUGAUAGUUGGUGUUCAAA	UUUGAACACCAACUAUCAA		[2770-2788]
374	AAUACAGACACUAAGUUAU	AUAACUUAGUGUCUGUAUU	大鼠，Ms	[2439-2457]
					375	GAGGUUUGGAUGGGAGUGA	UCACUCCCAUCCAAACCUC		[2577-2595]
376	AGACACUAAGUUAUAGUAU	AUACUAUAACUUAGUGUCU	大鼠，Ms	[2444-2462]
					377	UCUGUAGGGCUGGACCUAU	AUAGGUCCAGCCCUACAGA	Ms	[2032-2050]
378	AGGAGGUUUGGAUGGGAGU	ACUCCCAUCCAAACCUCCU		[2575-2593]
					379	AAAUCUGUUUGAUCCCUGU	ACAGGGAUCAAACAGAUUU		[2694-2712]
380	UCCUACCCAACCACUCAAA	UUUGAGUGGUUGGGUAGGA		[2188-2206]
					381	CAUCAUGGGCAACAAGGAC	GUCCUUGUUGCCCAUGAUG		[713-731]
382	GAGUUCUACAACCAGACAU	AUGUCUGGUUGUAGAACUC		[303-321]
					383	GUUGUCAAUAUUAAAUACA	UGUAUUUAAUAUUGACAAC	Ms	[2426-2444]
384	CUCUGUGGGCCUUUUCGUU	AACGAAAAGGCCCACAGAG		[422-440]
					385	CCAGAAGAAUAUUCAGGAC	GUCCUGAAUAUUCUUCUGG	大鼠	[1801-1819]
386	AACUGGGCAAGUCCUUUGA	UCAAAGGACUUGCCCAGUU	大鼠，Ms	[520-538]
					387	UCCAGUAUGUGGAGCAACU	AGUUGCUCCACAUACUGGA	Ms	[1444-1462]
388	AUGGGAGUGAGACAGAAGU	ACUUCUGUCUCACUCCCAU		[2586-2604]

389	UGGUGUUCAAAAAAACACU	AGUGUUUUUUUGAACACCA		[2778-2796]
					390	UGCUCAAGAAGACAUGGAG	CUCCAUGUCUUCUUGAGCA		[2359-2377]
391	CUUUAUCUUGACAUUCAAG	CUUGAAUGUCAAGAUAAAG		[2734-2752]
					392	AAAUCGCAUUAUUUUGAAU	AUUCAAAAUAAUGCGAUUU		[2828-2846]
393	UGAUGUCCAGAAGAAUAUU	AAUAUUCUUCUGGACAUCA		[1795-1813]
					394	AGCAAUGAUGUCCAGAAGA	UCUUCUGGACAUCAUUGCU		[1790-1808]
395	CACUUGCCUUCUUCACCCA	UGGGUGAAGAAGGCAAGUG		[2008-2026]
					396	CUCCUGGUUCUGUUCUUCA	UGAAGAACAGAACCAGGAG		[1497-1515]
397	GUCCCUUACACGUACCUCU	AGAGGUACGUGUAAGGGAC		[2654-2672]
					398	CUACAACACUGGAGUCAUC	GAUGACUCCAGUGUUGUAG		[260-278]
399	CUGGACCUCAAAUUUCAUU	AAUGAAAUUUGAGGUCCAG		[1412-1430]
					400	GCUGAUUCCCAAGUGUGAG	CUCACACUUGGGAAUCAGC		[1641-1659]
401	UGAUGCGGGAGAAGAAGGU	ACCUUCUUCUCCCGCAUCA	大鼠，Ms	[931-949]
					402	UCACUGUCGUGUCGCUGUU	AACAGCGACACGACAGUGA		[1138-1156]
403	CACAUAUUUGAUAGUUGGU	ACCAACUAUCAAAUAUGUG		[2763-2781]
					404	UCUAUUACUCCACGAGCAU	AUGCUCGUGGAGUAAUAGA		[1051-1069]
405	ACACCACCUCACUCCUGUU	AACAGGAGUGAGGUGGUGU		[2487-2505]
					406	AGGUUUGGAUGGGAGUGAG	CUCACUCCCAUCCAAACCU		[2578-2596]
407	UCAAAAAAACACUAGUUUU	AAAACUAGUGUUUUUUUGA		[2784-2802]
					408	UGCUGCUGAGCAUCAUCUU	AAGAUGAUGCUCAGCAGCA		[742-760]
409	CUAUCACAUAUUUGAUAGU	ACUAUCAAAUAUGUGAUAG		[2759-2777]
					410	GGGCAAGUCCUUUGAGAUG	CAUCUCAAAGGACUUGCCC	大鼠，Ms	[524-542]
411	ACUGUUGCUCAAAUCUAUU	AAUAGAUUUGAGCAACAGU		[1851-1869]
					412	CAUAUUUGAUAGUUGGUGU	ACACCAACUAUCAAAUAUG		[2765-2783]
413	GGCUUCACCCUGAAUGGUU	AACCAUUCAGGGUGAAGCC		[1954-1972]
					414	UUUCUAUCACAUAUUUGAU	AUCAAAUAUGUGAUAGAAA		[2756-2774]
415	AUUUUUGGUUGUCAAUAUU	AAUAUUGACAACCAAAAAU		[2419-2437]

416	CAGCUAAUCUGUAGGGCUG	CAGCCCUACAGAUUAGCUG		[2025-2043]
					417	GAAUAUUCAGGACUUAACG	CGUUAAGUCCUGAAUAUUC		[1807-1825]
418	UCCUCUUGCUCAAAAAUCU	AGAUUUUUGAGCAAGAGGA		[2681-2699]
					419	AGGAGUUCUACAACCAGAC	GUCUGGUUGUAGAACUCCU		[301-319]
420	UCCAGAAGAAUAUUCAGGA	UCCUGAAUAUUCUUCUGGA	大鼠	[1800-1818]
					421	GAUUGAGGGUAGGAGGUUU	AAACCUCCUACCCUCAAUC		[2565-2583]
422	AAAGUGAUAAGACACCCGA	UCGGGUGUCUUAUCACUUU		[1600-1618]
					423	UCAUUGUGGGCAUGUGCUU	AAGCACAUGCCCACAAUGA	Ms	[1426-1444]
424	AGGCUUGAAAUCGCAUUAU	AUAAUGCGAUUUCAAGCCU		[2821-2839]
					425	GUAUAGAUGCAAGAUAUUU	AAAUAUCUUGCAUCUAUAC		[2394-2412]
426	CAAAUUAAUCUUUCUUUAC	GUAAAGAAAGAUUAAUUUG		[2203-2221]
					427	CAAAAGCAAGACUGUUGCU	AGCAACAGUCUUGCUUUUG		[1841-1859]
428	UGUAAAUACACCACCUCAC	GUGAGGUGGUGUAUUUACA		[2480-2498]
					429	UGAAAUCGCAUUAUUUUGA	UCAAAAUAAUGCGAUUUCA		[2826-2844]
430	GGCCUUUUCGUUAACCGCU	AGCGGUUAACGAAAAGGCC		[429-447]
					431	UUCUUUAUCUUGACAUUCA	UGAAUGUCAAGAUAAAGAA		[2732-2750]
432	ACUCAUGACCAUCGCGCUA	UAGCGCGAUGGUCAUGAGU		[1226-1244]
					433	UACCCUGGAUGUCCUAUCU	AGAUAGGACAUCCAGGGUA		[1261-1279]
434	GACAAGCAACAGGUUUUAU	AUAAAACCUGUUGCUUGUC		[1872-1890]
					435	UAUAUUUUUGGUUGUCAAU	AUUGACAACCAAAAAUAUA		[2416-2434]
436	AGAAUAUUCAGGACUUAAC	GUUAAGUCCUGAAUAUUCU		[1806-1824]
					437	UGGAUGUCCUAUCUGAGCA	UGCUCAGAUAGGACAUCCA	Ms	[1266-1284]
438	AACUAUGAACUACAAAGCU	AGCUUUGUAGUUCAUAGUU		[2072-2090]
					439	UUUUGAAAUGCUUGUGGAU	AUCCACAAGCAUUUCAAAA		[2549-2567]
440	AUGAUGUCCAGAAGAAUAU	AUAUUCUUCUGGACAUCAU		[1794-1812]
					441	GAACUACAAAGCUUCUAUC	GAUAGAAGCUUUGUAGUUC		[2078-2096]
442	UUCCUACCCAACCACUCAA	UUGAGUGGUUGGGUAGGAA	Ms	[2187-2205]

443	CAUGUAUGUGGGUGAAGUG	CACUUCACCCACAUACAUG		[602-620]
					444	UGACCUGCAGGAGAUGAAG	CUUCAUCUCCUGCAGGUCA		[896-914]
445	UUGCUCAAAUCUAUUCAGA	UCUGAAUAGAUUUGAGCAA		[1855-1873]
					446	AGCAACAGGUUUUAUAAUU	AAUUAUAAAACCUGUUGCU		[1876-1894]
447	UGCUCCUGGUUCUGUUCUU	AAGAACAGAACCAGGAGCA		[1495-1513]
					448	CAGUCCCUUACACGUACCU	AGGUACGUGUAAGGGACUG		[2652-2670]
449	CACCACCUCACUCCUGUUA	UAACAGGAGUGAGGUGGUG		[2488-2506]
					450	CAAUAUUAAAUACAGACAC	GUGUCUGUAUUUAAUAUUG	Ms	[2431-2449]
451	AGAAACAUGGUUUUGAAAU	AUUUCAAAACCAUGUUUCU		[2539-2557]
					452	UGGACCUAUGUCCUAAGGA	UCCUUAGGACAUAGGUCCA		[2042-2060]
453	UCAUCAUCUUCACUGUGCU	AGCACAGUGAAGAUGAUGA		[1480-1498]
					454	CUUAACGGCUCCAGGAUUU	AAAUCCUGGAGCCGUUAAG		[1819-1837]
455	CCCUUCCCAUCUCUUCCUA	UAGGAAGAGAUGGGAAGGG		[2174-2192]
					456	AGAAGACAUGGAGACUCCU	AGGAGUCUCCAUGUCUUCU		[2365-2383]
457	AUGUCCAGAAGAAUAUUCA	UGAAUAUUCUUCUGGACAU		[1797-1815]
					458	CCUUCUCUGUGGGCCUUUU	AAAAGGCCCACAGAGAAGG		[418-436]
459	UGCCUUCUUCACCCAGCUA	UAGCUGGGUGAAGAAGGCA		[2012-2030]
					460	UCAAUAUUAAAUACAGACA	UGUCUGUAUUUAAUAUUGA	Ms	[2430-2448]
461	AUCCAGUCCCUUACACGUA	UACGUGUAAGGGACUGGAU		[2649-2667]
					462	UUGGUUGUCAAUAUUAAAU	AUUUAAUAUUGACAACCAA		[2423-2441]
463	GGCAUGUGCUUCCAGUAUG	CAUACUGGAAGCACAUGCC	Ms	[1434-1452]
					464	ACUGCAACGGCUUAGACUU	AAGUCUAAGCCGUUGCAGU		[2621-2639]
465	CGGGUUCUAGUCUCCUUUG	CAAAGGAGACUAGAACCCG		[2283-2301]
					466	GACCUUCGAUGAGAUCGCU	AGCGAUCUCAUCGAAGGUC	大鼠	[1553-1571]
467	AUUUGAUAGUUGGUGUUCA	UGAACACCAACUAUCAAAU		[2768-2786]
					468	GUUAUAGUAUAUCUGGACA	UGUCCAGAUAUACUAUAAC	Ms	[2453-2471]
469	GAUGCUCAGGCUUGAAAUC	GAUUUCAAGCCUGAGCAUC		[2814-2832]

470	CCACUCAAAUUAAUCUUUC	GAAAGAUUAAUUUGAGUGG		[2198-2216]
					471	CAACGCUGUCUUCUAUUAC	GUAAUAGAAGACAGCGUUG		[1040-1058]
472	UAGUCUCCUUUGCACUGAG	CUCAGUGCAAAGGAGACUA		[2290-2308]
					473	AUCUUGACAUUCAAGGCAU	AUGCCUUGAAUGUCAAGAU		[2738-2756]
474	AUGCGGGAGAAGAAGGUCA	UGACCUUCUUCUCCCGCAU	大鼠，Ms	[933-951]
					475	UCAAAUCUAUUCAGACAAG	CUUGUCUGAAUAGAUUUGA		[1859-1877]
476	CACUGUCGUGUCGCUGUUU	AAACAGCGACACGACAGUG		[1139-1157]
					477	CUGGAUGAGACUUCCAAAC	GUUUGGAAGUCUCAUCCAG		[1725-1743]
478	ACUAUGAACUACAAAGCUU	AAGCUUUGUAGUUCAUAGU		[2073-2091]
					479	UACUUACCUAAACAGAUAU	AUAUCUGUUUAGGUAAGUA		[2505-2523]
480	UCGUGUCGCUGUUUGUGGU	ACCACAAACAGCGACACGA		[1144-1162]
					481	CUAGUCUCCUUUGCACUGA	UCAGUGCAAAGGAGACUAG		[2289-2307]
482	GAAACUGGGCAAGUCCUUU	AAAGGACUUGCCCAGUUUC		[518-536]
					483	AAUCUGUAGGGCUGGACCU	AGGUCCAGCCCUACAGAUU	大鼠，Ms	[2030-2048]
484	GAAGAAGGUCACCAUCCUG	CAGGAUGGUGACCUUCUUC		[941-959]
					485	UGAAUGGUUCCAUGCCUGA	UCAGGCAUGGAACCAUUCA		[1964-1982]
486	CUUCGACUCAGGAUCCAGU	ACUGGAUCCUGAGUCGAAG		[2637-2655]
					487	AGCCCUAAGGAUCUCUCAG	CUGAGAGAUCCUUAGGGCU		[1694-1712]
488	CUCAAAUUAAUCUUUCUUU	AAAGAAAGAUUAAUUUGAG		[2201-2219]
					489	AUCUGUUUGAUCCCUGUUA	UAACAGGGAUCAAACAGAU		[2696-2714]
490	CAUUCAAGGCAUUUCUAUC	GAUAGAAAUGCCUUGAAUG		[2745-2763]
					491	UGUUGCUCAAAUCUAUUCA	UGAAUAGAUUUGAGCAACA		[1853-1871]
492	GAUGAGACUUCCAAACCUG	CAGGUUUGGAAGUCUCAUC		[1728-1746]
					493	AGCUUCUAUCCCAGGAGGU	ACCUCCUGGGAUAGAAGCU		[2087-2105]
494	AAUUCAAUGCUGAUGAUGA	UCAUCAUCAGCAUUGAAUU		[459-477]
					495	AAUAUUAAAUACAGACACU	AGUGUCUGUAUUUAAUAUU	Ms	[2432-2450]
496	CAAAAAAACACUAGUUUUG	CAAAACUAGUGUUUUUUUG		[2785-2803]

497	UGCUCAUCAACCGCAACGA	UCGUUGCGGUUGAUGAGCA		[820-838]
					498	CACGAGCAUCUUCGAGAAG	CUUCUCGAAGAUGCUCGUG		[1061-1079]
499	UUCCAAACCUGACAGAUGU	ACAUCUGUCAGGUUUGGAA		[1736-1754]
					500	UUCUAUCACAUAUUUGAUA	UAUCAAAUAUGUGAUAGAA		[2757-2775]

表B 29SLC2A2-溶质载体家族2，成员2

No.	正义链siRNA	反义链siRNA	其他Sp	人-4557850：310-1884
					1	UGAGGAAAUUGCUGCAGAA	UUCUGCAGCAAUUUCCUCA	Chmp	[1785-1803]
2	CCCUGUUCACAUUUUUUAA	UUAAAAAAUGUGAACAGGG	大鼠	[1739-1757]
					3	CACCAAAGAUAUUAAUGAA	UUCAUUAAUAUCUUUGGUG	Chmp	[1116-1134]
4	CAAGAUUUAACACUAAAAA	UUUUUAGUGUUAAAUCUUG	Chmp	[2569-2587]
					5	GGAAGUCAAAGCAAAACAA	UUGUUUUGCUUUGACUUCC	Chmp	[1065-1083]
6	CUGCAGAAUUCCAAAAGAA	UUCUUUUGGAAUUCUGCAG	Chmp	[1796-1814]
					7	GCAAGAUUUAACACUAAAA	UUUUAGUGUUAAAUCUUGC	Chmp	[2568-2586]
8	CGACGUUCUCUCUUUCUAA	UUAGAAAGAGAGAACGUCG	Chmp	[1402-1420]
					9	CAAUAAGUUCCAUGUUAAA	UUUAACAUGGAACUUAUUG	Chmp	[2320-2338]
10	GGUUAUCAGUUAACAUUAA	UUAAUGUUAACUGAUAACC	Chmp	[2612-2630]
					11	GAAGAAAAGCACUUUUUAA	UUAAAAAGUGCUUUUCUUC	Chmp	[3306-3324]
12	CCAUAUAUCUUAUGUUAAA	UUUAACAUAAGAUAUAUGG	Chmp	[2284-2302]
					13	GUUAGAUGAGGAAGUCAAA	UUUGACUUCCUCAUCUAAC	Chmp	[1056-1074]
14	CGUGGGUUAUCAGUUAACA	UGUUAACUGAUAACCCACG		[2608-2626]
					15	CAGCAAACCUGUUUAUGCA	UGCAUAAACAGGUUUGCUG	Chmp	[1314-1332]
16	GAAUUAUUAUGUCUCAAAA	UUUUGAGACAUAAUAAUUC	Chmp	[2848-2866]
					17	GCUUCAGACUUUUAUCAAA	UUUGAUAAAAGUCUGAAGC		[2931-2949]
18	CCAGAUACCUUUACAUCAA	UUGAUGUAAAGGUAUCUGG	Chmp	[1037-1055]
					19	GGACUUCUGUGGACCUUAU	AUAAGGUCCACAGAAGUCC	Chmp	[1683-1701]
20	CGGGCAUUCUUAUUAGUCA	UGACUAAUAAGAAUGCCCG	Chmp	[902-920]
					21	AAAUGUCUAUAGAGAAAAA	UUUUUCUCUAUAGACAUUU	Chmp	[2460-2478]

22	GAUUGAUCACUUUGUUAAA	UUUAACAAAGUGAUCAAUC		[2819-2837]
					23	UGAGGAAGUCAAAGCAAAA	UUUUGCUUUGACUUCCUCA	Chmp	[1062-1080]
24	CAUCAGAAAUGUCAUCAAA	UUUGAUGACAUUUCUGAUG	Chmp	[2006-2024]
					25	CCAUCUCAUAUACUUAUAA	UUAUAAGUAUAUGAGAUGG	Chmp	[754-772]
26	CCCACAAUCUCAUACUCAA	UUGAGUAUGAGAUUGUGGG	Chmp	[511-529]
					27	GACUUGUGCUGCUGAAUAA	UUAUUCAGCAGCACAAGUC	Chmp	[1466-1484]
28	GCAGAAUUCCAAAAGAAGA	UCUUCUUUUGGAAUUCUGC	Chmp	[1798-1816]
					29	GGACCAUCUCAUAUACUUA	UAAGUAUAUGAGAUGGUCC	Chmp	[751-769]
30	GAUUAUAGAGUAUACUAAA	UUUAGUAUACUCUAUAAUC		[2441-2459]
					31	GGAACCGUCUGUUUUUAAA	UUUAAAAACAGACGGUUCC	Chmp	[1925-1943]
32	GCUGCAGAAUUCCAAAAGA	UCUUUUGGAAUUCUGCAGC	Chmp	[1795-1813]
					33	CUGAGUGUGGGCUUCUGAA	UUCAGAAGCCCACACUCAG		[2896-2914]
34	GCAAUAAGUUCCAUGUUAA	UUAACAUGGAACUUAUUGC	Chmp	[2319-2337]
					35	CAGUUAACAUUAACAUCUA	UAGAUGUUAAUGUUAACUG	Chmp	[2618-2636]
36	GAGCAGAAAGUCUCUAUAA	UUAUAGAGACUUUCUGCUC	Chmp	[1165-1183]
					37	CAUACUCAAUGAACCCAAA	UUUGGGUUCAUUGAGUAUG	Chmp	[521-539]
38	ACAUGAACAGAAACAAUAA	UUAUUGUUUCUGUUCAUGU	Chmp	[1905-1923]
					39	GGCAUUUUUUACUACUCAA	UUGAGUAGUAAAAAAUGCC	Chmp	[1270-1288]
40	CCAUGUUAGUAGCAAACAU	AUGUUUGCUACUAACAUGG	Chmp	[689-707]
					41	GAAGUCAAAGCAAAACAAA	UUUGUUUUGCUUUGACUUC	Chmp	[1066-1084]
42	GUACAAUGACAGAAGAUAA	UUAUCUUCUGUCAUUGUAC	Chmp	[305-323]
					43	GAAUAUCAUUAAAUUGGAA	UUCCAAUUUAAUGAUAUUC	Chmp	[2256-2274]
44	GGAUUAUAGAGUAUACUAA	UUAGUAUACUCUAUAAUCC		[2440-2458]
					45	CAGUCAAUUUUACAAUUAU	AUAAUUGUAAAAUUGACUG	Chmp	[3169-3187]
46	CCCUGCUUUUUGACAUGAA	UUCAUGUCAAAAAGCAGGG	Chmp	[1893-1911]
					47	GUGGAACAAAGGUAUUGAA	UUCAAUACCUUUGUUCCAC		[50-68]
48	CUGGAUGACCGAAAAGCUA	UAGCUUUUCGGUCAUCCAG	Chmp	[457-475]

49	AGAUAUUAAUGAAAUGAGA	UCUCAUUUCAUUAAUAUCU	Chmp	[1122-1140]
					50	AGCUGCUGUAGAAAUGAAA	UUUCAUUUCUACAGCAGCU	Chmp	[1839-1857]
51	GAGGCAAAGCACUUAUUGA	UCAAUAAGUGCUUUGCCUC	Chmp	[82-100]
					52	CAACUGGAGCACUGAUCAA	UUGAUCAGUGCUCCAGUUG	Chmp	[3258-3276]
53	UAAGUUUGAUCAAAUCUAA	UUAGAUUUGAUCAAACUUA	Chmp	[2778-2796]
					54	CUGUAUUCCUUGUGGAGAA	UUCUCCACAAGGAAUACAG	Chmp	[1376-1394]
55	GAGAAAAGAAAGAGAAGAA	UUCUUCUCUUUCUUUUCUC	Chmp	[1137-1155]
					56	CACACUUGGAAGAAUCAAA	UUUGAUUCUUCCAAGUGUG	Chmp	[669-687]
57	AGGCAGAGCUGCGAAUAAA	UUUAUUCGCAGCUCUGCCU	Chmp	[217-235]
					58	GCAGCUGCUCAACUAAUCA	UGAUUAGUUGAGCAGCUGC	Chmp	[571-589]
59	CGUCCUGCUGCUUUAGCAA	UUGCUAAAGCAGCAGGACG	Chmp	[1603-1621]
					60	UGUGAUCAAUGCACCUCAA	UUGAGGUGCAUUGAUCACA	大鼠，Ms，Chmp	[396-414]
61	GAAUUUGUAUUUUGCUUAA	UUAAGCAAAAUACAAAUUC	Chmp	[2387-2405]
					62	UGCAAGAUUUAACACUAAA	UUUAGUGUUAAAUCUUGCA	Chmp	[2567-2585]
63	GGGUUAUCAGUUAACAUUA	UAAUGUUAACUGAUAACCC	Chmp	[2611-2629]
					64	GCUUCUGAAACUUCAUAAA	UUUAUGAAGUUUCAGAAGC	Chmp	[2906-2924]
65	GGCUUAUCAAAAUCUUUCA	UGAAAGAUUUUGAUAAGCC	Chmp	[2494-2512]
					66	CAAUUUUACAAUUAUGGAA	UUCCAUAAUUGUAAAAUUG	Chmp	[3173-3191]
67	CAUCUCAUAUACUUAUAAU	AUUAUAAGUAUAUGAGAUG	Chmp	[755-773]
					68	GAUCAAAUCUAAUGUAAGA	UCUUACAUUAGAUUUGAUC	Chmp	[2785-2803]
69	CCUACAUAGGCAAAUUGGA	UCCAAUUUGCCUAUGUAGG	Chmp	[3118-3136]
					70	GGUUUCACCUGAUCAUAUA	UAUAUGAUCAGGUGAAACC	Chmp	[2588-2606]
71	CAUCAAAUAUUACCAAAAA	UUUUUGGUAAUAUUUGAUG	Chmp	[2018-2036]
					72	GAGUUAUGUGAGCAUGAUA	UAUCAUGCUCACAUAACUC	Chmp	[1497-1515]
73	UCCACUGGAUGACCGAAAA	UUUUCGGUCAUCCAGUGGA	Chmp	[453-471]
					74	GACUUUAGCUUACAGUCAA	UUGACUGUAAGCUAAAGUC	Chmp	[3157-3175]
75	UCUGUAUUUUCAUGUGGAA	UUCCACAUGAAAAUACAGA	Chmp	[2420-2438]

76	CAGCACUCAGAAAAGAAAA	UUUUCUUUUCUGAGUGCUG	Chmp	[2511-2529]
					77	CGGACUUCUGUGGACCUUA	UAAGGUCCACAGAAGUCCG	Chmp	[1682-1700]
78	AAGCUGCUGUAGAAAUGAA	UUCAUUUCUACAGCAGCUU	Chmp	[1838-1856]
					79	UAAUGAAAUGAGAAAAGAA	UUCUUUUCUCAUUUCAUUA	Chmp	[1128-1146]
80	GUGAAAUAAUUAAAAACCA	UGGUUUUUAAUUAUUUCAC	Chmp	[3341-3359]
					81	GCAAAACAAAGCUUGAAAA	UUUUCAAGCUUUGUUUUGC	Chmp	[1075-1093]
82	UUGCAAGAUUUAACACUAA	UUAGUGUUAAAUCUUGCAA	Chmp	[2566-2584]
					83	GCAAUUUUCCGGAAUCAAU	AUUGAUUCCGGAAAAUUGC		[1251-1269]
84	CAAAUCUAAUGUAAGAAAA	UUUUCUUACAUUAGAUUUG	Chmp	[2788-2806]
					85	UCAGAAAUGUCAUCAAAUA	UAUUUGAUGACAUUUCUGA	Chmp	[2008-2026]
86	GACCGAAAAGCUAUCAACA	UGUUGAUAGCUUUUCGGUC	Chmp	[463-481]
					87	UGGGACUUGUGCUGCUGAA	UUCAGCAGCACAAGUCCCA	Chmp	[1463-1481]
88	UCAGAUUAUUGGUCUUGAA	UUCAAGACCAAUAAUCUGA	Chmp	[918-936]
					89	GCAGAAAGUCUCUAUAAUU	AAUUAUAGAGACUUUCUGC	Chmp	[1167-1185]
90	GACGGCUGGUAUCAGCAAA	UUUGCUGAUACCAGCCGUC	Chmp	[1302-1320]
					91	AGAAAAGCACUUUUUAAAA	UUUUAAAAAGUGCUUUUCU	Chmp	[3308-3326]
92	GUUUGUAACUUAUGCCUAA	UUAGGCAUAAGUUACAAAC	Chmp	[5-23]
					93	UAUCAAAAUCCCUAUUUAA	UUAAAUAGGGAUUUUGAUA	Chmp	[2943-2961]
94	CCUGUUCACAUUUUUUAAA	UUUAAAAAAUGUGAACAGG	大鼠	[1740-1758]
					95	AGCAGAAAGUCUCUAUAAU	AUUAUAGAGACUUUCUGCU	Chmp	[1166-1184]
96	GGGUGCUAACGUAUCUCUA	UAGAGAUACGUUAGCACCC		[3224-3242]
					97	CUACAUAGGCAAAUUGGAA	UUCCAAUUUGCCUAUGUAG	Chmp	[3119-3137]
98	GCUCUGUUCUUUAUAACAA	UUGUUAUAAAGAACAGAGC	Chmp	[2149-2167]
					99	GGGAACCGUCUGUUUUUAA	UUAAAAACAGACGGUUCCC	Chmp	[1924-1942]
100	UAACAAGGUUCUUCUAAAA	UUUUAGAAGAACCUUGUUA	Chmp	[2162-2180]
					101	UGGUUUUUGCAAGAUUUAA	UUAAAUCUUGCAAAAACCA	Chmp	[2560-2578]
102	GUAAUUAAGUAAACCAAAA	UUUUGGUUUACUUAAUUAC	Chmp	[2080-2098]

103	GGCUGAGUUUUUCAGUCAA	UUGACUGAAAAACUCAGCC	Chmp	[1578-1596]
					104	UAGGCAAAUUGGAAAUACA	UGUAUUUCCAAUUUGCCUA	Chmp	[3124-3142]
105	ACCUGAGGAUGCAACAAAU	AUUUGUUGCAUCCUCAGGU		[2225-2243]
					106	ACCGAAAAGCUAUCAACAA	UUGUUGAUAGCUUUUCGGU	Chmp	[464-482]
107	CAUCAAGUUAGAUGAGGAA	UUCCUCAUCUAACUUGAUG	Chmp	[1050-1068]
					108	AGGAAAGUCUUUUGAGGAA	UUCCUCAAAAGACUUUCCU	Ms，Chmp	[1773-1791]
109	AAAAAAUGUCUAUAGAGAA	UUCUCUAUAGACAUUUUUU	Chmp	[2457-2475]
					110	CUUUAAGAGUGAAAUAAUU	AAUUAUUUCACUCUUAAAG	Chmp	[3333-3351]
111	UCGUCACGGGCAUUCUUAU	AUAAGAAUGCCCGUGACGA	Chmp	[896-914]
					112	AGUUUGCUUUGCUUUUUAA	UUAAAAAGCAAAGCAAACU	Chmp	[2683-2701]
113	GAAAAGCACUUUUUAAAAA	UUUUUAAAAAGUGCUUUUC	Chmp	[3309-3327]
					114	CAUCGUCACGGGCAUUCUU	AAGAAUGCCCGUGACGAUG	Chmp	[894-912]
115	CGCAUUGUACACUAUCUAU	AUAGAUAGUGUACAAUGCG		[3090-3108]
					116	CAAUCUCAUACUCAAUGAA	UUCAUUGAGUAUGAGAUUG	Chmp	[515-533]
117	AUAUGAUGAUGUCACCAAA	UUUGGUGACAUCAUCAUAU	Chmp	[1104-1122]
					118	GUGGGUUAUCAGUUAACAU	AUGUUAACUGAUAACCCAC		[2609-2627]
119	AGGUUCUUCUAAAAUUGAA	UUCAAUUUUAGAAGAACCU	Chmp	[2167-2185]
					120	AGGGCAGGUGGUUCUAAUA	UAUUAGAACCACCUGCCCU	Chmp	[2124-2142]
121	AAUGAAAUGAGAAAAGAAA	UUUCUUUUCUCAUUUCAUU	Chmp	[1129-1147]
					122	CCUCCUCCUGCAAUGCAUA	UAUGCAUUGCAGGAGGAGG	Chmp	[189-207]
123	UAUCAACAGUACAGAUGAA	UUCAUCUGUACUGUUGAUA		[489-507]
					124	CACUGAUCAAUCCUUCUUA	UAAGAAGGAUUGAUCAGUG	Chmp	[3267-3285]
125	GCUGCAUUCAGCAAUUGGA	UCCAAUUGCUGAAUGCAGC	Chmp	[1624-1642]
					126	GAAUUGACAGGACUCCCAA	UUGGGAGUCCUGUCAAUUC	Chmp	[283-301]
127	CCUGAGGAUGCAACAAAUA	UAUUUGUUGCAUCCUCAGG		[2226-2244]
					128	UGUCUUAGCUGUAUACAGA	UCUGUAUACAGCUAAGACA	Chmp	[3037-3055]
129	GGACUAUAUUGUGGGCUAA	UUAGCCCACAAUAUAGUCC	Chmp	[793-811]

130	GAAAUGUCAUCAAAUAUUA	UAAUAUUUGAUGACAUUUC	Chmp	[2011-2029]
					131	AUGUGGAAUGGAUUAUAGA	UCUAUAAUCCAUUCCACAU	Chmp	[2431-2449]
132	GGUGGUUCUAAUAUUUUUA	UAAAAAUAUUAGAACCACC	Chmp	[2130-2148]
					133	CUUCAGACUUUUAUCAAAA	UUUUGAUAAAAGUCUGAAG		[2932-2950]
134	AAAAAUGUCUAUAGAGAAA	UUUCUCUAUAGACAUUUUU	Chmp	[2458-2476]
					135	CAACUAGUACAAUGACAGA	UCUGUCAUUGUACUAGUUG	Chmp	[299-317]
136	ACCUCAACAGGUAAUAAUA	UAUUAUUACCUGUUGAGGU	Chmp	[408-426]
					137	GUCUCAAAAUAAGUUGAAA	UUUCAACUUAUUUUGAGAC	Chmp	[2858-2876]
138	AAGAAAAGCACUUUUUAAA	UUUAAAAAGUGCUUUUCUU	Chmp	[3307-3325]
					139	UGAUCACUUUGUUAAAAAU	AUUUUUAACAAAGUGAUCA		[2822-2840]
140	GCUGCUGUAGAAAUGAAAU	AUUUCAUUUCUACAGCAGC	Chmp	[1840-1858]
					141	ACCUUUACAUCAAGUUAGA	UCUAACUUGAUGUAAAGGU	Chmp	[1043-1061]
142	GGCAAUAAGUUCCAUGUUA	UAACAUGGAACUUAUUGCC	Chmp	[2318-2336]
					143	GUGGGCUUCUGAAACUUCA	UGAAGUUUCAGAAGCCCAC	Chmp	[2902-2920]
144	GGUUUUCACAUACACUCAA	UUGAGUGUAUGUGAAAACC	Chmp	[2715-2733]
					145	CCGUCUGUUUUUAAAUGAU	AUCAUUUAAAAACAGACGG		[1929-1947]
146	UGAAUAUCAUUAAAUUGGA	UCCAAUUUAAUGAUAUUCA	Chmp	[2255-2273]
					147	GAUGAGGAAGUCAAAGCAA	UUGCUUUGACUUCCUCAUC	Chmp	[1060-1078]
148	CUGUAAUUAAGUAAACCAA	UUGGUUUACUUAAUUACAG	Chmp	[2078-2096]
					149	UGGAAUGGAUUAUAGAGUA	UACUCUAUAAUCCAUUCCA	Chmp	[2434-2452]
150	CUAGAAACCUGAGGAUGCA	UGCAUCCUCAGGUUUCUAG	Chmp	[2219-2237]
					151	GGAUGAGUUAUGUGAGCAU	AUGCUCACAUAACUCAUCC	大鼠，Chmp	[1493-1511]
152	CUCCUGCAAUGCAUAACUA	UAGUUAUGCAUUGCAGGAG	Chmp	[193-211]
					153	CAGAAAUGUCAUCAAAUAU	AUAUUUGAUGACAUUUCUG	Chmp	[2009-2027]
154	GAAUUUUCUUACCCAUAUA	UAUAUGGGUAAGAAAAUUC	Chmp	[2272-2290]
					155	GAAACUUCAUAAAUGUUCA	UGAACAUUUAUGAAGUUUC	Chmp	[2912-2930]
156	CCAAAAGCUGCUGUAGAAA	UUUCUACAGCAGCUUUUGG	Chmp	[1834-1852]

157	GGACUUGUGCUGCUGAAUA	UAUUCAGCAGCACAAGUCC	Chmp	[1465-1483]
					158	UGAGCAGAAAGUCUCUAUA	UAUAGAGACUUUCUGCUCA	Chmp	[1164-1182]
159	AUUCCUUGAGCAUUUUAUA	UAUAAAAUGCUCAAGGAAU	Chmp	[1949-1967]
					160	AAGGGCAGGUGGUUCUAAU	AUUAGAACCACCUGCCCUU	Chmp	[2123-2141]
161	UAAAGUUCCAGAAACCAAA	UUUGGUUUCUGGAACUUUA	大鼠，Ms，Chmp	[1755-1773]
					162	UGAAGAAAAGCACUUUUUA	UAAAAAGUGCUUUUCUUCA	Chmp	[3305-3323]
163	AGCAAUUUUCCGGAAUCAA	UUGAUUCCGGAAAAUUGCU		[1250-1268]
					164	GGGACCAUCUCAUAUACUU	AAGUAUAUGAGAUGGUCCC	Chmp	[750-768]
165	GCACCUCAACAGGUAAUAA	UUAUUACCUGUUGAGGUGC	Chmp	[406-424]
					166	CUAGUACAAUGACAGAAGA	UCUUCUGUCAUUGUACUAG	Chmp	[302-320]
167	AUGAGGAAGUCAAAGCAAA	UUUGCUUUGACUUCCUCAU	Chmp	[1061-1079]
					168	GAAAAGCUAUCAACAACUA	UAGUUGUUGAUAGCUUUUC	Chmp	[467-485]
169	CAGUCCAAAGAACAAGAAA	UUUCUUGUUCUUUGGACUG	Chmp	[3409-3427]
					170	GAGAUUUCAACAUAUCAUU	AAUGAUAUGUUGAAAUCUC	Chmp	[2186-2204]
171	CUGAAUUAUUAUGUCUCAA	UUGAGACAUAAUAAUUCAG	Chmp	[2846-2864]
					172	UAGGCAGAGCUGCGAAUAA	UUAUUCGCAGCUCUGCCUA	Chmp	[216-234]
173	CUCUUUUUCUGUCCAGAAA	UUUCUGGACAGAAAAAGAG	Chmp	[1015-1033]
					174	UGAGUGUGGGCUUCUGAAA	UUUCAGAAGCCCACACUCA		[2897-2915]
175	AGAGAUUUCAACAUAUCAU	AUGAUAUGUUGAAAUCUCU	Chmp	[2185-2203]
					176	CCCAGAUACCUUUACAUCA	UGAUGUAAAGGUAUCUGGG	Chmp	[1036-1054]
177	CACGGGCAUUCUUAUUAGU	ACUAAUAAGAAUGCCCGUG	Chmp	[900-918]
					178	GAUGCAACAAAUAUUUAUA	UAUAAAUAUUUGUUGCAUC		[2232-2250]
179	CUACCGACAGCCUAUUCUA	UAGAAUAGGCUGUCGGUAG	Chmp	[1206-1224]
					180	GAUAUUAAUGAAAUGAGAA	UUCUCAUUUCAUUAAUAUC	Chmp	[1123-1141]
181	GCAGUCCAAAGAACAAGAA	UUCUUGUUCUUUGGACUGC		[3408-3426]
					182	GAGUCAGACAUUUGGUAUA	UAUACCAAAUGUCUGACUC	Chmp	[2742-2760]
183	CACAUUUUUUAAAGUUCCA	UGGAACUUUAAAAAAUGUG	大鼠	[1746-1764]

184	CCUAAUAAGUUUGAUCAAA	UUUGAUCAAACUUAUUAGG	Chmp	[2773-2791]
					185	CCUCAACAGGUAAUAAUAU	AUAUUAUUACCUGUUGAGG	Chmp	[409-427]
186	CAAAGAACAAGAAAUUGUU	AACAAUUUCUUGUUCUUUG	Chmp	[3414-3432]
					187	AGCGUGGGUUAUCAGUUAA	UUAACUGAUAACCCACGCU		[2606-2624]
188	AGAAAGUCUCUAUAAUUCA	UGAAUUAUAGAGACUUUCU	Chmp	[1169-1187]
					189	CAAUGCACCUCAACAGGUA	UACCUGUUGAGGUGCAUUG	Chmp	[402-420]
190	GUAAGAAAAUUUGAAGUAA	UUACUUCAAAUUUUCUUAC	Chmp	[2798-2816]
					191	CCAAAGAUAUUAAUGAAAU	AUUUCAUUAAUAUCUUUGG	Chmp	[1118-1136]
192	AUGACAUUGGUGUGAUCAA	UUGAUCACACCAAUGUCAU	Chmp	[386-404]
					193	GCUUUUUUCUUGAGUACUA	UAGUACUCAAGAAAAAAGC	Chmp	[2368-2386]
194	ACAUAUAUGUAAUUUAGCA	UGCUAAAUUACAUAUAUGU		[3392-3410]
					195	UUUGGUAUAUUACCUCAAA	UUUGAGGUAAUAUACCAAA	Chmp	[2752-2770]
196	ACUGAUCAAUCCUUCUUAU	AUAAGAAGGAUUGAUCAGU	Chmp	[3268-3286]
					197	CCCAUAUAUCUUAUGUUAA	UUAACAUAAGAUAUAUGGG	Chmp	[2283-2301]
198	CACAGGUUGCUGAGGCAAA	UUUGCCUCAGCAACCUGUG	Chmp	[71-89]
					199	CAAACAUUCUGUCAUUAGU	ACUAAUGACAGAAUGUUUG	Chmp	[701-719]
200	AUGGUAAGACUGUAAUUAA	UUAAUUACAGUCUUACCAU	Chmp	[2069-2087]
					201	AUAACAAGGUUCUUCUAAA	UUUAGAAGAACCUUGUUAU	Chmp	[2161-2179]
202	AGUUGUUCACAUAUAUGUA	UACAUAUAUGUGAACAACU	Chmp	[3384-3402]
					203	GGAUGCAACAAAUAUUUAU	AUAAAUAUUUGUUGCAUCC		[2231-2249]
204	GUUUUUGCAAGAUUUAACA	UGUUAAAUCUUGCAAAAAC	Chmp	[2562-2580]
					205	AGAGUAUACUAAAAAAUGU	ACAUUUUUUAGUAUACUCU		[2447-2465]
206	UAGCGUGGGUUAUCAGUUA	UAACUGAUAACCCACGCUA		[2605-2623]
					207	GAGUGAGCAGAAAGUCUCU	AGAGACUUUCUGCUCACUC	Chmp	[1161-1179]
208	GGAUUGAUCACUUUGUUAA	UUAACAAAGUGAUCAAUCC		[2818-2836]
					209	UGAAGAGAUUUCAACAUAU	AUAUGUUGAAAUCUCUUCA	Chmp	[2182-2200]
210	CAUUCUUAUUAGUCAGAUU	AAUCUGACUAAUAAGAAUG	大鼠，Ms，Chmp	[906-924]

211	ACAUGUUUUGGGUGUUCCA	UGGAACACCCAAAACAUGU	Ms	[438-456]
					212	CUAUGUUAUCAACAGUACA	UGUACUGUUGAUAACAUAG		[483-501]
213	GGCAGGUGGUUCUAAUAUU	AAUAUUAGAACCACCUGCC	Chmp	[2126-2144]
					214	GCUAGUUUAUUUUGUUACA	UGUAACAAAAUAAACUAGC	Chmp	[2101-2119]
215	UCAUCAGAAAUGUCAUCAA	UUGAUGACAUUUCUGAUGA	Chmp	[2005-2023]
					216	CAUGUGGAAUGGAUUAUAG	CUAUAAUCCAUUCCACAUG	Chmp	[2430-2448]
217	GGAAAGUCUUUUGAGGAAA	UUUCCUCAAAAGACUUUCC	Ms，Chmp	[1774-1792]
					218	AGGGUUUGAGGAUUCCUGA	UCAGGAAUCCUCAAACCCU	Chmp	[2881-2899]
219	CCAACUGGAGCACUGAUCA	UGAUCAGUGCUCCAGUUGG	Chmp	[3257-3275]
					220	GAUGAUUAAACAGACUUUA	UAAAGUCUGUUUAAUCAUC	Chmp	[3145-3163]
221	CAGGCCUGGUUCCUAUGUA	UACAUAGGAACCAGGCCUG	Chmp	[815-833]
					222	AAAAUUGAAGAGAUUUCAA	UUGAAAUCUCUUCAAUUUU	Chmp	[2177-2195]
223	ACUAAAAAAUGUCUAUAGA	UCUAUAGACAUUUUUUAGU		[2454-2472]
					224	GAUCAAUCCUUCUUAUGUU	AACAUAAGAAGGAUUGAUC	Chmp	[3271-3289]
225	AGACAACUCUUCCAUUUAU	AUAAAUGGAAGAGUUGUCU	Chmp	[2341-2359]
					226	CGUCACGGGCAUUCUUAUU	AAUAAGAAUGCCCGUGACG	Chmp	[897-915]
227	GGCUUCUGAAACUUCAUAA	UUAUGAAGUUUCAGAAGCC	Chmp	[2905-2923]
					228	CAUUUGCUUUGUUUUCUAA	UUAGAAAACAAAGCAAAUG	Chmp	[3365-3383]
229	GACCAUCUCAUAUACUUAU	AUAAGUAUAUGAGAUGGUC	Chmp	[752-770]
					230	AGUUAGAUGAGGAAGUCAA	UUGACUUCCUCAUCUAACU	Chmp	[1055-1073]
231	AACCAAAAAGGCUAGUUUA	UAAACUAGCCUUUUUGGUU	Chmp	[2091-2109]
					232	ACGCAUUGUACACUAUCUA	UAGAUAGUGUACAAUGCGU		[3089-3107]
233	AGUUCUGAUGGGUCCCAAA	UUUGGGACCCAUCAGAACU	Chmp	[3196-3214]
					234	GAUUAGAUUCCCAUCAAUA	UAUUGAUGGGAAUCUAAUC	Chmp	[99-117]
235	GGACUCCCAACUAGUACAA	UUGUACUAGUUGGGAGUCC	Chmp	[292-310]
					236	CAUCCUUCAGUCUCUGCUA	UAGCAGAGACUGAAGGAUG	Chmp	[996-1014]
237	GCCUUUACCCUGUUCACAU	AUGUGAACAGGGUAAAGGC		[1732-1750]

238	ACAGGACUCCCAACUAGUA	UACUAGUUGGGAGUCCUGU	Chmp	[289-307]
					239	GAAAUUCCUAGGAGCUACA	UGUAGCUCCUAGGAAUUUC	Chmp	[1854-1872]
240	GACAUGAACAGAAACAAUA	UAUUGUUUCUGUUCAUGUC	Chmp	[1904-1922]
					241	GUUUUCACAUACACUCAAA	UUUGAGUGUAUGUGAAAAC	Chmp	[2716-2734]
242	GUAUCAGCAAACCUGUUUA	UAAACAGGUUUGCUGAUAC	Chmp	[1310-1328]
					243	UAAGUUCCAUGUUAAAAUA	UAUUUUAACAUGGAACUUA	Chmp	[2323-2341]
244	AAUUGCUGCAGAAUUCCAA	UUGGAAUUCUGCAGCAAUU	Chmp	[1791-1809]
					245	CAAAAUUGGGACCAUCUCA	UGAGAUGGUCCCAAUUUUG	Chmp	[743-761]
246	GCCUGGUUCCUAUGUAUAU	AUAUACAUAGGAACCAGGC	Chmp	[818-836]
					247	CCUUCUUAUGUUUGCUUUA	UAAAGCAAACAUAAGAAGG	Chmp	[3278-3296]
248	AAAGCAAAACAAAGCUUGA	UCAAGCUUUGUUUUGCUUU	Chmp	[1072-1090]
					249	GUUCCAGAAACCAAAGGAA	UUCCUUUGGUUUCUGGAAC	大鼠，Ms，Chmp	[1759-1777]
250	UCAGCACUCAGAAAAGAAA	UUUCUUUUCUGAGUGCUGA	Chmp	[2510-2528]
					251	AGGCUGUUUUCUCCACCAA	UUGGUGGAGAAAACAGCCU		[3242-3260]
252	CCACAAUCUCAUACUCAAU	AUUGAGUAUGAGAUUGUGG	Chmp	[512-530]
					253	AGACGGCUGGUAUCAGCAA	UUGCUGAUACCAGCCGUCU	Chmp	[1301-1319]
254	GUAAUAAUAUCUCACUAUA	UAUAGUGAGAUAUUAUUAC		[418-436]
					255	CCAAAUGGUUUUUGCAAGA	UCUUGCAAAAACCAUUUGG	Chmp	[2555-2573]
256	GGAAUGGAUUAUAGAGUAU	AUACUCUAUAAUCCAUUCC	Chmp	[2435-2453]
					257	ACCUGUUUAUGCAACCAUU	AAUGGUUGCAUAAACAGGU	Chmp	[1320-1338]
258	CAGCAAUUUUCCGGAAUCA	UGAUUCCGGAAAAUUGCUG		[1249-1267]
					259	GGACAGCCUGGUUUUCACA	UGUGAAAACCAGGCUGUCC		[2706-2724]
260	GCAGGUGGUUCUAAUAUUU	AAAUAUUAGAACCACCUGC	Chmp	[2127-2145]
					261	UGAGAAGAUUAGACUUGGA	UCCAAGUCUAAUCUUCUCA	Chmp	[130-148]
262	GGGCUUCUGAAACUUCAUA	UAUGAAGUUUCAGAAGCCC	Chmp	[2904-2922]
					263	CAAUCAUGAGUCAGACAUU	AAUGUCUGACUCAUGAUUG	Chmp	[2735-2753]
264	CUAAAGUUGUUCACAUAUA	UAUAUGUGAACAACUUUAG	Chmp	[3380-3398]

265	UCAUGUGGAAUGGAUUAUA	UAUAAUCCAUUCCACAUGA	Chmp	[2429-2447]
					266	GCGACGUUCUCUCUUUCUA	UAGAAAGAGAGAACGUCGC	Chmp	[1401-1419]
267	AGGCAAAGCACUUAUUGAU	AUCAAUAAGUGCUUUGCCU	Chmp	[83-101]
					268	AGGUAAUAAUAUCUCACUA	UAGUGAGAUAUUAUUACCU		[416-434]
269	UGUAAUUAAGUAAACCAAA	UUUGGUUUACUUAAUUACA	Chmp	[2079-2097]
					270	CAAAAAGGCUAGUUUAUUU	AAAUAAACUAGCCUUUUUG	Chmp	[2094-2112]
271	GCUCCCAUUUUCUUUCCUA	UAGGAAAGAAAAUGGGAGC	Chmp	[31-49]
					272	GGGCAUUCUUAUUAGUCAG	CUGACUAAUAAGAAUGCCC	Chmp	[903-921]
273	GAAAGUCUUUUGAGGAAAU	AUUUCCUCAAAAGACUUUC	Ms，Chmp	[1775-1793]
					274	UUAGCAGGGUGCUAACGUA	UACGUUAGCACCCUGCUAA		[3218-3236]
275	AGUUAACAUUAACAUCUAU	AUAGAUGUUAAUGUUAACU	Chmp	[2619-2637]
					276	UGACAUUGGUGUGAUCAAU	AUUGAUCACACCAAUGUCA	Chmp	[387-405]
277	UGAUUAGAUUCCCAUCAAU	AUUGAUGGGAAUCUAAUCA	Chmp	[98-116]
					278	CACGCAUUGUACACUAUCU	AGAUAGUGUACAAUGCGUG		[3088-3106]
279	UAAAGUUGUUCACAUAUAU	AUAUAUGUGAACAACUUUA	Chmp	[3381-3399]
					280	GGACCUGCUCCCAUUUUCU	AGAAAAUGGGAGCAGGUCC	Chmp	[25-43]
281	UCCUAAUAAGUUUGAUCAA	UUGAUCAAACUUAUUAGGA	Chmp	[2772-2790]
					282	AAAAUAAGUUGAAAAGGUA	UACCUUUUCAACUUAUUUU	Chmp	[2863-2881]
283	CUAAUGUAAGAAAAUUUGA	UCAAAUUUUCUUACAUUAG	Chmp	[2793-2811]
					284	CUAUUUAAUUUUCCUGGAA	UUCCAGGAAAAUUAAAUAG	Chmp	[2954-2972]
285	UUAGCAGUCCAAAGAACAA	UUGUUCUUUGGACUGCUAA		[3405-3423]
					286	GUAGGCUUAUCAAAAUCUU	AAGAUUUUGAUAAGCCUAC	Chmp	[2491-2509]
287	CCUCAAAUUCCUAAUAAGU	ACUUAUUAGGAAUUUGAGG		[2764-2782]
					288	AGCAAAACAAAGCUUGAAA	UUUCAAGCUUUGUUUUGCU	Chmp	[1074-1092]
289	GUCUUAGCUGUAUACAGAU	AUCUGUAUACAGCUAAGAC	Chmp	[3038-3056]
					290	AUGUAAUUUAGCAGUCCAA	UUGGACUGCUAAAUUACAU		[3398-3416]
291	ACAAGACCUGGAAUUGACA	UGUCAAUUCCAGGUCUUGU	Chmp	[273-291]

292	GCAGAGCUGCGAAUAAACA	UGUUUAUUCGCAGCUCUGC	Chmp	[219-237]
					293	GAAUGAGUGGGAUGUUUGU	ACAAACAUCCCACUCAUUC	Chmp	[1424-1442]
294	GAAACCUGAGGAUGCAACA	UGUUGCAUCCUCAGGUUUC		[2222-2240]
					295	AAUUUAGCAGUCCAAAGAA	UUCUUUGGACUGCUAAAUU		[3402-3420]
296	CGCUGAGAAGAUUAGACUU	AAGUCUAAUCUUCUCAGCG	Chmp	[127-145]
					297	AUUGCUGCAGAAUUCCAAA	UUUGGAAUUCUGCAGCAAU	Chmp	[1792-1810]
298	CACUCAGCUUUUUUCUUGA	UCAAGAAAAAAGCUGAGUG	Chmp	[2362-2380]
					299	ACUUAUAAUUGCUGGAAGA	UCUUCCAGCAAUUAUAAGU	Chmp	[765-783]
300	CCAUUUUAGUUCCUUUAUU	AAUAAAGGAACUAAAAUGG		[2530-2548]
					301	CUUUGUCAGCUUCUUUGAA	UUCAAAGAAGCUGACAAAG	Chmp	[1527-1545]
302	UGGGCUUCUGAAACUUCAU	AUGAAGUUUCAGAAGCCCA	Chmp	[2903-2921]
					303	GAUCAUAUAGCGUGGGUUA	UAACCCACGCUAUAUGAUC		[2598-2616]
304	GAUCACUUUGUUAAAAAUA	UAUUUUUAACAAAGUGAUC		[2823-2841]
					305	UGACAUGAACAGAAACAAU	AUUGUUUCUGUUCAUGUCA	Chmp	[1903-1921]
306	CAUUGGUGUGAUCAAUGCA	UGCAUUGAUCACACCAAUG	Chmp	[390-408]
					307	AUGUCACCAAAGAUAUUAA	UUAAUAUCUUUGGUGACAU	Ms，Chmp	[1112-1130]
308	CACAUAACUAGAAACCUGA	UCAGGUUUCUAGUUAUGUG	Chmp	[2212-2230]
					309	AUGGUUUUUGCAAGAUUUA	UAAAUCUUGCAAAAACCAU	Chmp	[2559-2577]
310	UGUUCCUAACAUAAAAUAA	UUAUUUUAUGUUAGGAACA	Chmp	[2993-3011]
					311	CUGAAUAAGUUCUCUUGGA	UCCAAGAGAACUUAUUCAG	Chmp	[1477-1495]
312	UUUGCAAGAUUUAACACUA	UAGUGUUAAAUCUUGCAAA	Chmp	[2565-2583]
					313	CUGUAGAAAUGAAAUUCCU	AGGAAUUUCAUUUCUACAG	Chmp	[1844-1862]
314	GGAAAGACUGAUUGUUUUA	UAAAACAAUCAGUCUUUCC	Chmp	[2969-2987]
					315	UUUGGUAGGCUUAUCAAAA	UUUUGAUAAGCCUACCAAA	Chmp	[2487-2505]
316	ACCAUCUCAUAUACUUAUA	UAUAAGUAUAUGAGAUGGU	Chmp	[753-771]
					317	GGCCUUUACCCUGUUCACA	UGUGAACAGGGUAAAGGCC		[1731-1749]
318	AAUAAUAUCUCACUAUAGA	UCUAUAGUGAGAUAUUAUU		[420-438]

319	ACCCUGUUCACAUUUUUUA	UAAAAAAUGUGAACAGGGU	大鼠	[1738-1756]
					320	UGUAGAAAUGAAAUUCCUA	UAGGAAUUUCAUUUCUACA	Chmp	[1845-1863]
321	UGAUGAUGUCACCAAAGAU	AUCUUUGGUGACAUCAUCA	Chmp	[1107-1125]
					322	AGGCCUGGUUCCUAUGUAU	AUACAUAGGAACCAGGCCU	Chmp	[816-834]
323	UUUUGGUAGGCUUAUCAAA	UUUGAUAAGCCUACCAAAA	Chmp	[2486-2504]
					324	CACCAAUUCCAGCUACCGA	UCGGUAGCUGGAAUUGGUG	Chmp	[1194-1212]
325	GAGAAAAACUUUCAUUUUU	AAAAAUGAAAGUUUUUCUC	Chmp	[2471-2489]
					326	CCUUUACCCUGUUCACAUU	AAUGUGAACAGGGUAAAGG		[1733-1751]
327	GUCUGUUUUUAAAUGAUGA	UCAUCAUUUAAAAACAGAC		[1931-1949]
					328	CCCUGGUUUUCACUGUCAU	AUGACAGUGAAAACCAGGG	Chmp	[335-353]
329	GAGGAUGCAACAAAUAUUU	AAAUAUUUGUUGCAUCCUC		[2229-2247]
					330	CGGUGAAAUUGCUCCAACC	GGUUGGAGCAAUUUCACCG	Chmp	[837-855]
331	UUAUGUGCUCUCAUCAGAA	UUCUGAUGAGAGCACAUAA	Chmp	[1995-2013]
					332	GGCCUGGUUCCUAUGUAUA	UAUACAUAGGAACCAGGCC	Chmp	[817-835]
333	GCUGCUCAACUAAUCACCA	UGGUGAUUAGUUGAGCAGC	Chmp	[574-592]
					334	AAUUGGACCUGCAAUUUCA	UGAAAUUGCAGGUCCAAUU	Chmp	[1636-1654]
335	ACCUCAAAUUCCUAAUAAG	CUUAUUAGGAAUUUGAGGU		[2763-2781]
					336	CAUUCUGUCAUUAGUUGGA	UCCAACUAAUGACAGAAUG	Chmp	[705-723]
337	AGAUGAGGAAGUCAAAGCA	UGCUUUGACUUCCUCAUCU	Chmp	[1059-1077]
					338	CAUUUUAUAUCCACAUCUU	AAGAUGUGGAUAUAAAAUG	Chmp	[1959-1977]
339	GAUGAUGUCACCAAAGAUA	UAUCUUUGGUGACAUCAUC	Chmp	[1108-1126]
					340	GUUUAUUUUGUUACACUAA	UUAGUGUAACAAAAUAAAC	Chmp	[2105-2123]
341	CUUUUUGACAUGAACAGAA	UUCUGUUCAUGUCAAAAAG	Chmp	[1898-1916]
					342	AAUGAGAAAAGAAAGAGAA	UUCUCUUUCUUUUCUCAUU	Chmp	[1134-1152]
343	UUAGCUCUGUUCUUUAUAA	UUAUAAAGAACAGAGCUAA	Chmp	[2146-2164]
					344	CUAUCUGCCUUUACCUACA	UGUAGGUAAAGGCAGAUAG		[3105-3123]
345	CUAAUAAGUUUGAUCAAAU	AUUUGAUCAAACUUAUUAG	Chmp	[2774-2792]

346	UUAUCAAAAUCCCUAUUUA	UAAAUAGGGAUUUUGAUAA	Chmp	[2942-2960]
					347	CUCUCAUCAGAAAUGUCAU	AUGACAUUUCUGAUGAGAG	Chmp	[2002-2020]
348	AAUCUUUCAGCACUCAGAA	UUCUGAGUGCUGAAAGAUU	Chmp	[2504-2522]
					349	GUAAGACUGUAAUUAAGUA	UACUUAAUUACAGUCUUAC	Chmp	[2072-2090]
350	AAGAGAUUUCAACAUAUCA	UGAUAUGUUGAAAUCUCUU	Chmp	[2184-2202]
					351	UUUUUGACAUGAACAGAAA	UUUCUGUUCAUGUCAAAAA	Chmp	[1899-1917]
352	AAGCAUCGAGUGAGCAGAA	UUCUGCUCACUCGAUGCUU	Chmp	[1154-1172]
					353	CAAACAAUCAUGAGUCAGA	UCUGACUCAUGAUUGUUUG	Chmp	[2731-2749]
354	CUCAAACAAUCAUGAGUCA	UGACUCAUGAUUGUUUGAG	Chmp	[2729-2747]
					355	AAGCAAAACAAAGCUUGAA	UUCAAGCUUUGUUUUGCUU	Chmp	[1073-1091]
356	AAAUUGGGACCAUCUCAUA	UAUGAGAUGGUCCCAAUUU	Chmp	[745-763]
					357	CAGAUGAACUGCCCACAAU	AUUGUGGGCAGUUCAUCUG	Chmp	[500-518]
358	CAAUGAACCCAAAACCAAC	GUUGGUUUUGGGUUCAUUG	Chmp	[527-545]
					359	GCAGGGUGCUAACGUAUCU	AGAUACGUUAGCACCCUGC		[3221-3239]
360	ACAGAUGAACUGCCCACAA	UUGUGGGCAGUUCAUCUGU	Chmp	[499-517]
					361	GAUUUAACACUAAAAAGGU	ACCUUUUUAGUGUUAAAUC	Chmp	[2572-2590]
362	AGAAAAGAAAACCAUUUUA	UAAAAUGGUUUUCUUUUCU	Chmp	[2519-2537]
					363	CUCCUCCUGCAAUGCAUAA	UUAUGCAUUGCAGGAGGAG	Chmp	[190-208]
364	UAUGUGCUCUCAUCAGAAA	UUUCUGAUGAGAGCACAUA	Chmp	[1996-2014]
					365	AGGCUAGUUUAUUUUGUUA	UAACAAAAUAAACUAGCCU	Chmp	[2099-2117]
366	UCUCAAAAUAAGUUGAAAA	UUUUCAACUUAUUUUGAGA	Chmp	[2859-2877]
					367	GUAUAUCGGUGAAAUUGCU	AGCAAUUUCACCGAUAUAC	Chmp	[831-849]
368	UCUGAAUUAUUAUGUCUCA	UGAGACAUAAUAAUUCAGA	Chmp	[2845-2863]
					369	CUAUGUAUAUCGGUGAAAU	AUUUCACCGAUAUACAUAG	Chmp	[827-845]
370	GACGUUCUCUCUUUCUAAU	AUUAGAAAGAGAGAACGUC	Chmp	[1403-1421]
					371	AGUUCCAUGUUAAAAUAGA	UCUAUUUUAACAUGGAACU	Chmp	[2325-2343]
372	AGGGAACCGUCUGUUUUUA	UAAAAACAGACGGUUCCCU	Chmp	[1923-1941]

373	UGAUCAAUGCACCUCAACA	UGUUGAGGUGCAUUGAUCA	Chmp	[398-416]
					374	UCCUAUGUAUAUCGGUGAA	UUCACCGAUAUACAUAGGA	Chmp	[825-843]
375	CAAUAGCUGCAUUCAGCAA	UUGCUGAAUGCAGCUAUUG	Chmp	[1619-1637]
					376	UCAAUGAACCCAAAACCAA	UUGGUUUUGGGUUCAUUGA	Chmp	[526-544]
377	CAUACACUCAAACAAUCAU	AUGAUUGUUUGAGUGUAUG	Chmp	[2723-2741]
					378	UGAGGAUGCAACAAAUAUU	AAUAUUUGUUGCAUCCUCA		[2228-2246]
379	CAAAGAUAUUAAUGAAAUG	CAUUUCAUUAAUAUCUUUG	Chmp	[1119-1137]
					380	CUGUAAACAUGGUUUUCAC	GUGAAAACCAUGUUUACAG	Chmp	[1349-1367]
381	GAACAGAAACAAUAAGGGA	UCCCUUAUUGUUUCUGUUC	Chmp	[1909-1927]
					382	UAAAAAAUGUCUAUAGAGA	UCUCUAUAGACAUUUUUUA	Chmp	[2456-2474]
383	CCUAGUGGAACAAAGGUAU	AUACCUUUGUUCCACUAGG		[46-64]
					384	GAACCGUCUGUUUUUAAAU	AUUUAAAAACAGACGGUUC	Chmp	[1926-1944]
385	GAAAGUCUCUAUAAUUCAG	CUGAAUUAUAGAGACUUUC	Chmp	[1170-1188]
					386	AGUUUAUUUUGUUACACUA	UAGUGUAACAAAAUAAACU	Chmp	[2104-2122]
387	UCACAUAUAUGUAAUUUAG	CUAAAUUACAUAUAUGUGA		[3390-3408]
					388	CAUUUUCUUUCCUAGUGGA	UCCACUAGGAAAGAAAAUG	Chmp	[36-54]
389	GCAAAGCACUUAUUGAUUA	UAAUCAAUAAGUGCUUUGC	Chmp	[85-103]
					390	GGCAGCUGCUCAACUAAUC	GAUUAGUUGAGCAGCUGCC	Chmp	[570-588]
391	GUUCCUAACAUAAAAUAAU	AUUAUUUUAUGUUAGGAAC	Chmp	[2994-3012]
					392	GGCAGAGCUGCGAAUAAAC	GUUUAUUCGCAGCUCUGCC	Chmp	[218-236]
393	GGUACAAUCCUUUGAGUUA	UAACUCAAAGGAUUGUACC		[2663-2681]
					394	CCUUUACCUACAUAGGCAA	UUGCCUAUGUAGGUAAAGG	Chmp	[3112-3130]
395	AAGUUUGAUCAAAUCUAAU	AUUAGAUUUGAUCAAACUU	Chmp	[2779-2797]
					396	ACCAAAGAUAUUAAUGAAA	UUUCAUUAAUAUCUUUGGU	Chmp	[1117-1135]
397	GUUGUUCACAUAUAUGUAA	UUACAUAUAUGUGAACAAC	Chmp	[3385-3403]
					398	UCACAUACACUCAAACAAU	AUUGUUUGAGUGUAUGUGA	Chmp	[2720-2738]
399	GGAAUUGACAGGACUCCCA	UGGGAGUCCUGUCAAUUCC	Chmp	[282-300]

400	GACUCAGAGGAUAUGAUGA	UCAUCAUAUCCUCUGAGUC	Chmp	[1094-1112]
					401	CCUAUUUAAUUUUCCUGGA	UCCAGGAAAAUUAAAUAGG	Chmp	[2953-2971]
402	AGGUGGUUCUAAUAUUUUU	AAAAAUAUUAGAACCACCU	Chmp	[2129-2147]
					403	GACAACUCUUCCAUUUAUU	AAUAAAUGGAAGAGUUGUC		[2342-2360]
404	GCUUACAGUCAAUUUUACA	UGUAAAAUUGACUGUAAGC	Chmp	[3164-3182]
					405	UCAUAAAUGUUCAGCUUCA	UGAAGCUGAACAUUUAUGA	Chmp	[2918-2936]
406	AAUUAAAAACCACUGAACA	UGUUCAGUGGUUUUUAAUU	Chmp	[3348-3366]
					407	UCUUUAAGAGUGAAAUAAU	AUUAUUUCACUCUUAAAGA	Chmp	[3332-3350]
408	GAAAAUUUGAAGUAAAGGA	UCCUUUACUUCAAAUUUUC	Chmp	[2802-2820]
					409	UUUAUAUCCACAUCUUUAA	UUAAAGAUGUGGAUAUAAA	Chmp	[1962-1980]
410	GAAGCAUAUCAGGACUAUA	UAUAGUCCUGAUAUGCUUC	Chmp	[782-800]
					411	GCAAUAGCUGCAUUCAGCA	UGCUGAAUGCAGCUAUUGC	Chmp	[1618-1636]
412	AACAGGUAAUAAUAUCUCA	UGAGAUAUUAUUACCUGUU		[413-431]
					413	AAAUGAGAAAAGAAAGAGA	UCUCUUUCUUUUCUCAUUU	Chmp	[1133-1151]
414	UCAGACAUUUGGUAUAUUA	UAAUAUACCAAAUGUCUGA	Chmp	[2745-2763]
					415	CAUUUUAGUUCCUUUAUUU	AAAUAAAGGAACUAAAAUG		[2531-2549]
416	GGGACUUGUGCUGCUGAAU	AUUCAGCAGCACAAGUCCC	Chmp	[1464-1482]
					417	CACCAACUGGAGCACUGAU	AUCAGUGCUCCAGUUGGUG	Chmp	[3255-3273]
418	AGCAAACCUGUUUAUGCAA	UUGCAUAAACAGGUUUGCU	Chmp	[1315-1333]
					419	CCCAACUAGUACAAUGACA	UGUCAUUGUACUAGUUGGG	Chmp	[297-315]
420	CUCAAUGAACCCAAAACCA	UGGUUUUGGGUUCAUUGAG	Chmp	[525-543]
					421	CAGCUCUUCACCAAUUCCA	UGGAAUUGGUGAAGAGCUG	Chmp	[1186-1204]
422	ACUCUUUAAGAGUGAAAUA	UAUUUCACUCUUAAAGAGU	Chmp	[3330-3348]
					423	CUGCUCAACUAAUCACCAU	AUGGUGAUUAGUUGAGCAG	Chmp	[575-593]
424	CAUUUGGUAUAUUACCUCA	UGAGGUAAUAUACCAAAUG	Chmp	[2750-2768]
					425	GCUGAGGCAAAGCACUUAU	AUAAGUGCUUUGCCUCAGC	Chmp	[79-97]
426	GGAAUUUUCUUACCCAUAU	AUAUGGGUAAGAAAAUUCC	Chmp	[2271-2289]

427	CUGCUUUUUGACAUGAACA	UGUUCAUGUCAAAAAGCAG	Chmp	[1895-1913]
					428	CAAUUAUGGAAAUAUAGUU	AACUAUAUUUCCAUAAUUG	Chmp	[3181-3199]
429	GAAGAUAAGGUCACUGGGA	UCCCAGUGACCUUAUCUUC	Chmp	[316-334]
					430	CGAAAAGCUAUCAACAACU	AGUUGUUGAUAGCUUUUCG	Chmp	[466-484]
431	UGUAAUUUAGCAGUCCAAA	UUUGGACUGCUAAAUUACA		[3399-3417]
					432	UGAGCAUUUUAUAUCCACA	UGUGGAUAUAAAAUGCUCA	Chmp	[1955-1973]
433	UCAACAACUAUGUUAUCAA	UUGAUAACAUAGUUGUUGA	Chmp	[476-494]
					434	GUGUGAUCAAUGCACCUCA	UGAGGUGCAUUGAUCACAC	大鼠，Ms，Chmp	[395-413]
435	AGCACUUAUUGAUUAGAUU	AAUCUAAUCAAUAAGUGCU	Chmp	[89-107]
					436	CCAAAGGAAAGUCUUUUGA	UCAAAAGACUUUCCUUUGG	大鼠，Ms，Chmp	[1769-1787]
437	GAUGGGUCCCAAAAGCUUA	UAAGCUUUUGGGACCCAUC	Chmp	[3202-3220]
					438	AAAAGAAAACCAUUUUAGU	ACUAAAAUGGUUUUCUUUU	Chmp	[2521-2539]
439	CUAUCAACAACUAUGUUAU	AUAACAUAGUUGUUGAUAG	Chmp	[473-491]
					440	AGGAAGUCAAAGCAAAACA	UGUUUUGCUUUGACUUCCU	Chmp	[1064-1082]
441	CACAAGACCUGGAAUUGAC	GUCAAUUCCAGGUCUUGUG	Chmp	[272-290]
					442	ACUGGAUGACCGAAAAGCU	AGCUUUUCGGUCAUCCAGU	Chmp	[456-474]
443	CCUAGGAGCUACAGAGACU	AGUCUCUGUAGCUCCUAGG	Chmp	[1860-1878]
					444	GAAUGGAUUAUAGAGUAUA	UAUACUCUAUAAUCCAUUC	Chmp	[2436-2454]
445	UGCUUUGCUUUUUAAUUGA	UCAAUUAAAAAGCAAAGCA	Chmp	[2687-2705]
					446	AGCUUCAGACUUUUAUCAA	UUGAUAAAAGUCUGAAGCU		[2930-2948]
447	CUUCUUAUGUUUGCUUUAA	UUAAAGCAAACAUAAGAAG	Chmp	[3279-3297]
					448	UUGGUAGGCUUAUCAAAAU	AUUUUGAUAAGCCUACCAA	Chmp	[2488-2506]
449	ACAUCAAGUUAGAUGAGGA	UCCUCAUCUAACUUGAUGU	Chmp	[1049-1067]
					450	CACUCAGAAAAGAAAACCA	UGGUUUUCUUUUCUGAGUG	Chmp	[2514-2532]
451	CUUUUGUUCUGUAUUUUCA	UGAAAAUACAGAACAAAAG	Chmp	[2413-2431]
					452	UAGUUUGCUUUGCUUUUUA	UAAAAAGCAAAGCAAACUA	Chmp	[2682-2700]
453	AGCUGUAUACAGAUUCUAG	CUAGAAUCUGUAUACAGCU	Chmp	[3043-3061]

454	CUCUGUUCUUUAUAACAAG	CUUGUUAUAAAGAACAGAG	Chmp	[2150-2168]
					455	UCAGCAAUUGGACCUGCAA	UUGCAGGUCCAAUUGCUGA	Chmp	[1631-1649]
456	UGGAUUAUAGAGUAUACUA	UAGUAUACUCUAUAAUCCA		[2439-2457]
					457	AAUGGUUUUUGCAAGAUUU	AAAUCUUGCAAAAACCAUU	Chmp	[2558-2576]
458	UGUUGAUUCCCUUCUGGUA	UACCAGAAGGGAAUCAACA		[2648-2666]
					459	AGAUUCCCAUCAAUAUUCA	UGAAUAUUGAUGGGAAUCU	Chmp	[103-121]
460	AGCUCUGUUCUUUAUAACA	UGUUAUAAAGAACAGAGCU	Chmp	[2148-2166]
					461	CUUACAGUCAAUUUUACAA	UUGUAAAAUUGACUGUAAG	Chmp	[3165-3183]
462	UGAAAUGAGAAAAGAAAGA	UCUUUCUUUUCUCAUUUCA	Chmp	[1131-1149]
					463	GCAUAACUAGGCCUAGGCA	UGCCUAGGCCUAGUUAUGC	Chmp	[203-221]
464	CCUGCUUUUUGACAUGAAC	GUUCAUGUCAAAAAGCAGG	Chmp	[1894-1912]
					465	CACCUCAACAGGUAAUAAU	AUUAUUACCUGUUGAGGUG	Chmp	[407-425]
466	GGUUUUUGCAAGAUUUAAC	GUUAAAUCUUGCAAAAACC	Chmp	[2561-2579]
					467	ACAUUUGCUUUGUUUUCUA	UAGAAAACAAAGCAAAUGU	Chmp	[3364-3382]
468	AGCCUGGUUUUCACAUACA	UGUAUGUGAAAACCAGGCU	Chmp	[2710-2728]
					469	CAUUUUUUAAAGUUCCAGA	UCUGGAACUUUAAAAAAUG	大鼠，Chmp	[1748-1766]
470	UGAAUUAUUAUGUCUCAAA	UUUGAGACAUAAUAAUUCA	Chmp	[2847-2865]
					471	UACCUCAAAUUCCUAAUAA	UUAUUAGGAAUUUGAGGUA		[2762-2780]
472	GAUUAUUGGUCUUGAAUUU	AAAUUCAAGACCAAUAAUC	Chmp	[921-939]
					473	AGCAGUCCAAAGAACAAGA	UCUUGUUCUUUGGACUGCU		[3407-3425]
474	CUUCUUUGUCUUAGCUGUA	UACAGCUAAGACAAAGAAG	Chmp	[3031-3049]
					475	AGGAUGCAACAAAUAUUUA	UAAAUAUUUGUUGCAUCCU		[2230-2248]
476	AAUUGAAGAGAUUUCAACA	UGUUGAAAUCUCUUCAAUU	Chmp	[2179-2197]
					477	GAUUCCUUGAGCAUUUUAU	AUAAAAUGCUCAAGGAAUC	Chmp	[1948-1966]
478	AUAAUUAAAAACCACUGAA	UUCAGUGGUUUUUAAUUAU	Chmp	[3346-3364]
					479	GCUGCCGCUGAGAAGAUUA	UAAUCUUCUCAGCGGCAGC	Chmp	[122-140]
480	CAGCUUUGCAGUUGGUGGA	UCCACCAACUGCAAAGCUG	Chmp	[615-633]

481	GAUUAGACUUGGACUCUCA	UGAGAGUCCAAGUCUAAUC	Chmp	[136-154]
					482	UGGUAAGACUGUAAUUAAG	CUUAAUUACAGUCUUACCA	Chmp	[2070-2088]
483	UGAGUUAUGUGAGCAUGAU	AUCAUGCUCACAUAACUCA	Chmp	[1496-1514]
					484	CUGAGGAUGCAACAAAUAU	AUAUUUGUUGCAUCCUCAG		[2227-2245]
485	CCUGGUUUUCACAUACACU	AGUGUAUGUGAAAACCAGG	Chmp	[2712-2730]
					486	GGGCAGGUGGUUCUAAUAU	AUAUUAGAACCACCUGCCC	Chmp	[2125-2143]
487	UGAUGUCACCAAAGAUAUU	AAUAUCUUUGGUGACAUCA	Chmp	[1110-1128]
					488	CAAAAGCUGCUGUAGAAAU	AUUUCUACAGCAGCUUUUG	Chmp	[1835-1853]
489	GGUUUUCACUGUCAUCACU	AGUGAUGACAGUGAAAACC		[339-357]
					490	CACAGAUGAUUAAACAGAC	GUCUGUUUAAUCAUCUGUG	Chmp	[3141-3159]
491	GUUUGCUUUGCUUUUUAAU	AUUAAAAAGCAAAGCAAAC	Chmp	[2684-2702]
					492	UGCAGAAUUCCAAAAGAAG	CUUCUUUUGGAAUUCUGCA	Chmp	[1797-1815]
493	UGGGUGUUCCACUGGAUGA	UCAUCCAGUGGAACACCCA	Ms，Chmp	[446-464]
					494	UGAAGUAAAGGAUUGAUCA	UGAUCAAUCCUUUACUUCA	Chmp	[2809-2827]
495	CAUAUAGCGUGGGUUAUCA	UGAUAACCCACGCUAUAUG		[2601-2619]
					496	AAGGAUUGAUCACUUUGUU	AACAAAGUGAUCAAUCCUU		[2816-2834]
497	AAUUUAUCUUGGGCAAUUA	UAAUUGCCCAAGAUAAAUU	Chmp	[935-953]
					498	GAAAAGACUCAGAGGAUAU	AUAUCCUCUGAGUCUUUUC	Chmp	[1089-1107]
499	GCUGUUUUCUCCACCAACU	AGUUGGUGGAGAAAACAGC		[3244-3262]
					500	CAAAAUAAGUUGAAAAGGU	ACCUUUUCAACUUAUUUUG	Chmp	[2862-2880]

表  30SLC2A3-溶质载体家族2

No.	正义链siRNA	反义链siRNA	其他Sp	人-221136810：263-1753
					1	CCAGAUUUUUGCUCAUUAA	UUAAUGAGCAAAAAUCUGG		[888-906]
2	CAAGGAUGCAGGUGUUCAA	UUGAACACCUGCAUCCUUG		[1150-1168]
					3	CGGUUUGUUGGAUCUUCAA	UUGAAGAUCCAACAAACCG		[1905-1923]
4	CAAGGAUGUCACAAGAAAA	UUUUCUUGUGACAUCCUUG		[1002-1020]
					5	GCUCAUUAACAGAAAAGAA	UUCUUUUCUGUUAAUGAGC		[898-916]

6	CUUGAAUCUUUCCAAUAAA	UUUAUUGGAAAGAUUCAAG		[3148-3166]
					7	GCAAGGAUGUCACAAGAAA	UUUCUUGUGACAUCCUUGC		[1001-1019]
8	ACGGCGUCAUGGAGAUGAA	UUCAUCUCCAUGACGCCGU		[1695-1713]
					9	CGGAGAUUAUAAAUAGUCA	UGACUAUUUAUAAUCUCCG		[74-92]
10	GGUUAAGGUGCAAUAAGAA	UUCUUAUUGCACCUUAACC		[2449-2467]
					11	CCAGGAAGCAGAUACAUAU	AUAUGUAUCUGCUUCCUGG		[2121-2139]
12	CCUGGAGCCUUUGAAUAAA	UUUAUUCAAAGGCUCCAGG		[3422-3440]
					13	CUGAGAAGGACAUUUUGAA	UUCAAAAUGUCCUUCUCAG		[169-187]
14	CACCCAGGAUGUAUCCCAA	UUGGGAUACAUCCUGGGUG		[955-973]
					15	AACCCAGGACGCUUCUGAA	UUCAGAAGCGUCCUGGGUU		[1831-1849]
16	GAAGGAAAUUGAGAUUAGA	UCUAAUCUCAAUUUCCUUC		[2381-2399]
					17	GAGAGGUUAUAGAGUAGAA	UUCUACUCUAUAACCUCUC		[2414-2432]
18	CUGGAGCCUUUGAAUAAAA	UUUUAUUCAAAGGCUCCAG		[3423-3441]
					19	CUAGGAUUAUUAACUAAUA	UAUUAGUUAAUAAUCCUAG		[2670-2688]
20	GCCGGAGGGUGUUUAUGUA	UACAUAAACACCCUCCGGC		[2150-2168]
					21	GGUUCUUUGUUUUAAAAUA	UAUUUUAAAACAAAGAACC		[3898-3916]
22	GGGAUAUAGGAGAGGAAAA	UUUUCCUCUCCUAUAUCCC		[2071-2089]
					23	CUGUUUCUUUGUUAUUAAA	UUUAAUAACAAAGAAACAG		[1311-1329]
24	GCGGUUUGUUGGAUCUUCA	UGAAGAUCCAACAAACCGC		[1904-1922]
					25	UCUGGUUCUUUGUUUUAAA	UUUAAAACAAAGAACCAGA		[3895-3913]
26	CUGGUUCUUUGUUUUAAAA	UUUUAAAACAAAGAACCAG		[3896-3914]
					27	GUACGUUAUUGUUGACUUA	UAAGUCAACAAUAACGUAC		[3256-3274]
28	GAAGGACUCUGCAUAUGAU	AUCAUAUGCAGAGUCCUUC		[1254-1272]
					29	GGGACUUGAAUCUUUCCAA	UUGGAAAGAUUCAAGUCCC		[3144-3162]
30	GGAAGUACGUUAUUGUUGA	UCAACAAUAACGUACUUCC		[3252-3270]
					31	GGAGUCCAGGGAAGAGAAA	UUUCUCUUCCCUGGACUCC		[2733-2751]
32	CAGAGAUGCUGUAAUGGUA	UACCAUUACAGCAUCUCUG		[109-127]

33	GGAGGGUGUUUAUGUAAGA	UCUUACAUAAACACCCUCC		[2153-2171]
					34	CUGAGAAGAUCAUAAAGGA	UCCUUUAUGAUCUUCUCAG		[363-381]
35	GGAGAAAUGUUGUUCAUUA	UAAUGAACAACAUUUCUCC		[2473-2491]
					36	GUACGUUACCUCUUAACAA	UUGUUAAGAGGUAACGUAC		[2524-2542]
37	UGGAGCCUUUGAAUAAAAA	UUUUUAUUCAAAGGCUCCA		[3424-3442]
					38	GCUCCUGAGAAGAUCAUAA	UUAUGAUCUUCUCAGGAGC		[359-377]
39	CGUGCUAGAGCUCUUUAGA	UCUAAAGAGCUCUAGCACG		[1030-1048]
					40	CUUUGUUAUUAAAGGAUAA	UUAUCCUUUAAUAACAAAG		[1317-1335]
41	GAUGGUUGAUGGGUUCUAA	UUAGAACCCAUCAACCAUC		[2706-2724]
					42	CGUUAUUGUUGACUUAUUU	AAAUAAGUCAACAAUAACG		[3259-3277]
43	GGAGAUUUUAGGUGUUGAU	AUCAACACCUAAAAUCUCC		[2924-2942]
					44	CUCUUUAACUUCUCGUAAA	UUUACGAGAAGUUAAAGAG		[2564-2582]
45	GGAUGAGCUUUGUCUGUAU	AUACAGACAAAGCUCAUCC		[1344-1362]
					46	CGGGUGUGGUUAAUACUAU	AUAGUAUUAACCACACCCG		[1194-1212]
47	GGUAGAGAUUCAUUAUUUU	AAAAUAAUGAAUCUCUACC		[2889-2907]
					48	CCAAAUAAUAAAAACAGAA	UUCUGUUUUUAUUAUUUGG		[2365-2383]
49	CCAGGUUUAGACAGUAUGA	UCAUACUGUCUAAACCUGG		[3167-3185]
					50	GGAGCCUUUGAAUAAAAAU	AUUUUUAUUCAAAGGCUCC		[3425-3443]
51	CCAAAUAAGAAACCUAAAA	UUUUAGGUUUCUUAUUUGG		[2858-2876]
					52	CUUCCAUUUUGCCCUGAAA	UUUCAGGGCAAAAUGGAAG		[866-884]
53	AGGUUAAGGUGCAAUAAGA	UCUUAUUGCACCUUAACCU		[2448-2466]
					54	GAAUGUAUGUGCACUGUCA	UGACAGUGCACAUACAUUC		[3220-3238]
55	GAGAAAUGUUGUUCAUUAU	AUAAUGAACAACAUUUCUC		[2474-2492]
					56	GGCGCAAUUCAAUGCUGAU	AUCAGCAUUGAAUUGCGCC		[531-549]
57	GGUGCAGAUAGAUCUGGAA	UUCCAGAUCUAUCUGCACC		[1673-1691]
					58	GGAGCUUUUUUCUUUAAGA	UCUUAAAGAAAAAAGCUCC		[2621-2639]
59	GGUUCUUGGUAGAGAUUCA	UGAAUCUCUACCAAGAACC		[2882-2900]

60	CGGUGCAGAUAGAUCUGGA	UCCAGAUCUAUCUGCACCG		[1672-1690]
					61	CUCCUGAGAAGAUCAUAAA	UUUAUGAUCUUCUCAGGAG		[360-378]
62	CUUGAAGACUUGAAUUAGA	UCUAAUUCAAGUCUUCAAG		[236-254]
					63	CUUUGUAGCCUUCUUUGAA	UUCAAAGAAGGCUACAAAG		[1378-1396]
64	UGGAGUCCAGGGAAGAGAA	UUCUCUUCCCUGGACUCCA		[2732-2750]
					65	GAUGGGUUCUAAUUUUGGA	UCCAAAAUUAGAACCCAUC		[2713-2731]
66	GCCUGAGGUCUGUACGUUA	UAACGUACAGACCUCAGGC		[2513-2531]
					67	CAUGUAGUAGUACUUGAAA	UUUCAAGUACUACUACAUG		[2650-2668]
68	GUGCAAGGAUGUCACAAGA	UCUUGUGACAUCCUUGCAC		[999-1017]
					69	CUAAGGAGACCACCACCAA	UUGGUGGUGGUCUCCUUAG		[1728-1746]
70	GGGUGUUUAUGUAAGAGCA	UGCUCUUACAUAAACACCC		[2156-2174]
					71	UCUGAAUGCUGCUACUUAA	UUAAGUAGCAGCAUUCAGA		[1844-1862]
72	GAGGAUGAAUGUAUGUGCA	UGCACAUACAUUCAUCCUC		[3214-3232]
					73	GAAUCUUUCCAAUAAACCA	UGGUUUAUUGGAAAGAUUC		[3151-3169]
74	GGACUUGAAUCUUUCCAAU	AUUGGAAAGAUUCAAGUCC		[3145-3163]
					75	GUUCAUUAUUGGAGGGUAA	UUACCCUCCAAUAAUGAAC		[2484-2502]
76	CAGGGAAGAGAAAGUGAUU	AAUCACUUUCUCUUCCCUG		[2739-2757]
					77	UGAAAUCUAGGAUUAUUAA	UUAAUAAUCCUAGAUUUCA		[2664-2682]
78	AGAGGUUAAGGUGCAAUAA	UUAUUGCACCUUAACCUCU		[2446-2464]
					79	GCGGGUGUGGUUAAUACUA	UAGUAUUAACCACACCCGC		[1193-1211]
80	CAGUAUGAGUCAAUGUGCA	UGCACAUUGACUCAUACUG		[3178-3196]
					81	GGAUGUCACAAGAAAAGCA	UGCUUUUCUUGUGACAUCC		[1005-1023]
82	ACUUGAAUCUUUCCAAUAA	UUAUUGGAAAGAUUCAAGU		[3147-3165]
					83	GGGCAUCGUUGUUGGAAUU	AAUUCCAACAACGAUGCCC		[742-760]
84	AGAUAAUAGUUUACAUGUA	UACAUGUAAACUAUUAUCU		[2637-2655]
					85	GUCUGUACGUUACCUCUUA	UAAGAGGUAACGUACAGAC		[2520-2538]
86	CAUCCUUCCUGCUAUCCUA	UAGGAUAGCAGGAAGGAUG		[835-853]

87	CAAAGAAUGUUUAUAGCAA	UUGCUAUAAACAUUCUUUG		[2983-3001]
					88	GACUUUGGAUCCUUCCUGA	UCAGGAAGGAUCCAAAGUC		[129-147]
89	CCAGAUCUUUGGUCUGGAA	UUCCAGACCAAAGAUCUGG		[769-787]
					90	GAUUGUGAAUAUUUCCAUA	UAUGGAAAUAUUCACAAUC		[3858-3876]
91	CCCAGAUUUUUGCUCAUUA	UAAUGAGCAAAAAUCUGGG		[887-905]
					92	GAGAGGUUAAGGUGCAAUA	UAUUGCACCUUAACCUCUC		[2445-2463]
93	UCUUUAACUUCUCGUAAAA	UUUUACGAGAAGUUAAAGA		[2565-2583]
					94	AGACCACCACCAAUGUCUA	UAGACAUUGGUGGUGGUCU		[1734-1752]
95	CAAAUUAACUUGAGUUUUA	UAAAACUCAAGUUAAUUUG		[2205-2223]
					96	AAAGAAUGUUUAUAGCAAA	UUUGCUAUAAACAUUCUUU		[2984-3002]
97	UCAGAUGGAAACUCUUUAA	UUAAAGAGUUUCCAUCUGA		[2553-2571]
					98	GCCUUUGAAUAAAAAUGCA	UGCAUUUUUAUUCAAAGGC		[3428-3446]
99	CUGAGAAGAUUGUGAAUAU	AUAUUCACAAUCUUCUCAG		[3851-3869]
					100	AAGUCAUAUACCUAUAUAA	UUAUAUAGGUAUAUGACUU		[2582-2600]
101	GCUUUUUUCUUUAAGAUAA	UUAUCUUAAAGAAAAAAGC		[2624-2642]
					102	AGGUGACCUUGCAACUUCA	UGAAGUUGCAAGGUCACCU		[3774-3792]
103	AUUCAAUGCUGAUUGUCAA	UUGACAAUCAGCAUUGAAU		[537-555]
					104	CAUCGUUGUUGGAAUUCUG	CAGAAUUCCAACAACGAUG		[745-763]
105	ACAUGUAGUAGUACUUGAA	UUCAAGUACUACUACAUGU		[2649-2667]
					106	GACCACCACCAAUGUCUAA	UUAGACAUUGGUGGUGGUC		[1735-1753]
107	AGAGGGAGGUGUUUAAAGA	UCUUUAAACACCUCCCUCU		[2397-2415]
					108	CAGGUUUUGUGCCCAUGUA	UACAUGGGCACAAAACCUG		[666-684]
109	ACUGUUUCUUUGUUAUUAA	UUAAUAACAAAGAAACAGU		[1310-1328]
					110	GAUUUUCUGUUGUAUUUUA	UAAAAUACAACAGAAAAUC		[2940-2958]
111	AGCCCAUCAUCAUUUCCAU	AUGGAAAUGAUGAUGGGCU		[1065-1083]
					112	CCCUUUGCGGAGAUUAUAA	UUAUAAUCUCCGCAAAGGG		[67-85]
113	UCUGUACGUUACCUCUUAA	UUAAGAGGUAACGUACAGA		[2521-2539]

114	CGCUGCUCACUAUUUAGGA	UCCUAAAUAGUGAGCAGCG		[1528-1546]
					115	CAGGAUGUAUCCCAAGACA	UGUCUUGGGAUACAUCCUG		[959-977]
116	GGAGAAAACUUGCUGCUGA	UCAGCAGCAAGUUUUCUCC		[154-172]
					117	AGCCUUCUUUGAAAUUGGA	UCCAAUUUCAAAGAAGGCU		[1384-1402]
118	CUCCGCUGCUCACUAUUUA	UAAAUAGUGAGCAGCGGAG		[1525-1543]
					119	UCCAAAUAAGAAACCUAAA	UUUAGGUUUCUUAUUUGGA		[2857-2875]
120	CCCUCACUGGAUGAAAUAA	UUAUUUCAUCCAGUGAGGG		[2774-2792]
					121	CUCACUGGAUGAAAUAACU	AGUUAUUUCAUCCAGUGAG		[2776-2794]
122	CCAUGUCACUGUGGUCCUA	UAGGACCACAGUGACAUGG		[3109-3127]
					123	GACUUUUGAGGAUAUCACA	UGUGAUAUCCUCAAAAGUC		[1630-1648]
124	GGCUUUUACCUUCUUCAAA	UUUGAAGAAGGUAAAAGCC		[1591-1609]
					125	CCGAGUGAACCUACCUUCA	UGAAGGUAGGUUCACUCGG		[1973-1991]
126	UGUUGUAUUUUAACUCAUA	UAUGAGUUAAAAUACAACA		[2947-2965]
					127	CGAUUAUUAUCUAAAGUGU	ACACUUUAGAUAAUAAUCG		[3048-3066]
128	GAUACAUAUGAGUGUGGAA	UUCCACACUCAUAUGUAUC		[2131-2149]
					129	CAGUGUAGCCCACACUUGA	UCAAGUGUGGGCUACACUG		[3195-3213]
130	ACUCAACAGGAAUCUUCAA	UUGAAGAUUCCUGUUGAGU	Ms	[1134-1152]
					131	GGAGAUUAUAAAUAGUCAU	AUGACUAUUUAUAAUCUCC		[75-93]
132	CCUUGGGUCUGAAGAGCUA	UAGCUCUUCAGACCCAAGG		[793-811]
					133	CCUAGAUCUUUCUUGAAGA	UCUUCAAGAAAGAUCUAGG		[225-243]
134	GAUGUCACAAGAAAAGCAA	UUGCUUUUCUUGUGACAUC		[1006-1024]
					135	CCUUUGCGGAGAUUAUAAA	UUUAUAAUCUCCGCAAAGG		[68-86]
136	GGGUCAUCAAUGCUCCUGA	UCAGGAGCAUUGAUGACCC		[348-366]
					137	GAGCCUACGUUUUUAUUAU	AUAAUAAAAACGUAGGCUC		[1545-1563]
138	AGAUCAUAAAGGAAUUUAU	AUAAAUUCCUUUAUGAUCU		[369-387]
					139	GGGCAUUGUAGUUAAUGAU	AUCAUUAACUACAAUGCCC		[2690-2708]
140	CCGGAGGGUGUUUAUGUAA	UUACAUAAACACCCUCCGG		[2151-2169]

141	CAUCAAUGCUCCUGAGAAG	CUUCUCAGGAGCAUUGAUG		[352-370]
					142	GAGUGAACCUACCUUCAUU	AAUGAAGGUAGGUUCACUC		[1975-1993]
143	CCUUCCUGCUAUCCUACAA	UUGUAGGAUAGCAGGAAGG		[838-856]
					144	GGGCUAUCUUGGUCUUUGU	ACAAAGACCAAGAUAGCCC		[1365-1383]
145	CAACAGGAAUCUUCAAGGA	UCCUUGAAGAUUCCUGUUG	Ms	[1137-1155]
					146	CCAUCACAGUUGCUACAAU	AUUGUAGCAACUGUGAUGG		[300-318]
147	GAUGAAAGAUGAGAGUGCA	UGCACUCUCAUCUUUCAUC		[985-1003]
					148	CCAGGGAAGAGAAAGUGAU	AUCACUUUCUCUUCCCUGG		[2738-2756]
149	GAUUAUAAAUAGUCAUGAU	AUCAUGACUAUUUAUAAUC		[78-96]
					150	GUGGAAAGGGCAGGAAGAA	UUCUUCCUGCCCUUUCCAC		[1238-1256]
151	ACUCAUACCUUUAAAGGAA	UUCCUUUAAAGGUAUGAGU		[2959-2977]
					152	CCGGCUUCCUCAUUACCUU	AAGGUAAUGAGGAAGCCGG		[1569-1587]
153	UGAGAAGAUCAUAAAGGAA	UUCCUUUAUGAUCUUCUCA		[364-382]
					154	CGAGUGAACCUACCUUCAU	AUGAAGGUAGGUUCACUCG		[1974-1992]
155	CCUUGUCAGUGACAGUAUU	AAUACUGUCACUGACAAGG		[3372-3390]
					156	GAGGUUAUAGAGUAGAAGA	UCUUCUACUCUAUAACCUC		[2416-2434]
157	GCUCCUGGAGCCUUUGAAU	AUUCAAAGGCUCCAGGAGC		[3419-3437]
					158	UGGGCAUCGUUGUUGGAAU	AUUCCAACAACGAUGCCCA		[741-759]
159	GCUGAGAAGGACAUUUUGA	UCAAAAUGUCCUUCUCAGC		[168-186]
					160	CAGGAAGAAGGACUCUGCA	UGCAGAGUCCUUCUUCCUG		[1248-1266]
161	UAGUCUCAUUACUUUUGAA	UUCAAAAGUAAUGAGACUA		[2806-2824]
					162	GAGCGAUUAUUAUCUAAAG	CUUUAGAUAAUAAUCGCUC		[3045-3063]
163	GAGACCUCAUCAGGAUGAA	UUCAUCCUGAUGAGGUCUC	Ms	[1814-1832]
					164	GGUUCUAAUUUUGGAUGGA	UCCAUCCAAAAUUAGAACC		[2717-2735]
165	UGGAGAGGUUAAGGUGCAA	UUGCACCUUAACCUCUCCA		[2443-2461]
					166	CACUGAGAAGAUUGUGAAU	AUUCACAAUCUUCUCAGUG		[3849-3867]
167	CGCGGGUGUGGUUAAUACU	AGUAUUAACCACACCCGCG		[1192-1210]

168	UUUGUAGCCUUCUUUGAAA	UUUCAAAGAAGGCUACAAA		[1379-1397]
					169	GCAGCUCUCUGGGAUCAAU	AUUGAUCCCAGAGAGCUGC	Ms	[1102-1120]
170	GAAAGGGCAGGAAGAAGGA	UCCUUCUUCCUGCCCUUUC		[1241-1259]
					171	AGGGAGAAAUGUUGUUCAU	AUGAACAACAUUUCUCCCU		[2471-2489]
172	GAUGGAAACUCUUUAACUU	AAGUUAAAGAGUUUCCAUC		[2556-2574]
					173	AAGACAUCCAGGAGAUGAA	UUCAUCUCCUGGAUGUCUU		[972-990]
174	GUAGCUAAGUCGGUUGAAA	UUUCAACCGACUUAGCUAC		[599-617]
					175	UAAUAAAAACAGAAGGAAA	UUUCCUUCUGUUUUUAUUA		[2370-2388]
176	GAAGAAGGACUCUGCAUAU	AUAUGCAGAGUCCUUCUUC		[1251-1269]
					177	GGUCAUCAAUGCUCCUGAG	CUCAGGAGCAUUGAUGACC		[349-367]
178	UGUAGUUAAUGAUGGUUGA	UCAACCAUCAUUAACUACA		[2696-2714]
					179	ACAGCAUCGAGCCUGCUAA	UUAGCAGGCUCGAUGCUGU		[1713-1731]
180	CAUCCAAAUAAGAAACCUA	UAGGUUUCUUAUUUGGAUG		[2855-2873]
					181	CUUGGUAGAGAUUCAUUAU	AUAAUGAAUCUCUACCAAG		[2886-2904]
182	GGAGAGACCUCAUCAGGAU	AUCCUGAUGAGGUCUCUCC		[1811-1829]
					183	GCAGGACUUUUGAGGAUAU	AUAUCCUCAAAAGUCCUGC		[1626-1644]
184	AGCAAGUCACCGUGCUAGA	UCUAGCACGGUGACUUGCU		[1020-1038]
					185	UAGUUUACAUGUAGUAGUA	UACUACUACAUGUAAACUA		[2643-2661]
186	CUGAGCGAUUAUUAUCUAA	UUAGAUAAUAAUCGCUCAG		[3043-3061]
					187	GUGUUGAUUUUCUGUUGUA	UACAACAGAAAAUCAACAC		[2935-2953]
188	CGUAAAAGUCAUAUACCUA	UAGGUAUAUGACUUUUACG		[2577-2595]
					189	GGAAGCAGAUACAUAUGAG	CUCAUAUGUAUCUGCUUCC		[2124-2142]
190	CCUUGCAACUUCAUGUCAA	UUGACAUGAAGUUGCAAGG		[3780-3798]
					191	CGCUCAUGACUGUUUCUUU	AAAGAAACAGUCAUGAGCG		[1302-1320]
192	GGAAGAAGGACUCUGCAUA	UAUGCAGAGUCCUUCUUCC		[1250-1268]
					193	GCAAACUUGGAAUUUGUAA	UUACAAAUUCCAAGUUUGC		[2998-3016]
194	CUUUGACGGACAAGGGAAA	UUUCCCUUGUCCGUCAAAG		[396-414]

195	AGGACAUUUUGAAGGUUUU	AAAACCUUCAAAAUGUCCU		[175-193]
					196	GAAGAGAAAGUGAUUUCUA	UAGAAAUCACUUUCUCUUC		[2743-2761]
197	UCAUCAAUGCUCCUGAGAA	UUCUCAGGAGCAUUGAUGA		[351-369]
					198	CCUUCAGAUGGAAACUCUU	AAGAGUUUCCAUCUGAAGG		[2550-2568]
199	CCCAGGAUGUAUCCCAAGA	UCUUGGGAUACAUCCUGGG		[957-975]
					200	GAAAUAACUCCUUCUUGUA	UACAAGAAGGAGUUAUUUC		[2786-2804]
201	GAUUUUAGGUGUUGAUUUU	AAAAUCAACACCUAAAAUC		[2927-2945]
					202	CAGUAUUUUGGUUCUUAGU	ACUAAGAACCAAAAUACUG		[3384-3402]
203	CUUGGAAUUUGUAACCUCA	UGAGGUUACAAAUUCCAAG		[3003-3021]
					204	AUUAGAGGGAGGUGUUUAA	UUAAACACCUCCCUCUAAU		[2394-2412]
205	AAGUGUGCUUUAGCUUGAA	UUCAAGCUAAAGCACACUU		[3754-3772]
					206	UUUGCUCAUUAACAGAAAA	UUUUCUGUUAAUGAGCAAA		[895-913]
207	UGGGCAUUGUAGUUAAUGA	UCAUUAACUACAAUGCCCA		[2689-2707]
					208	GUGUGCUUUAGCUUGAAAA	UUUUCAAGCUAAAGCACAC		[3756-3774]
209	AGAGAUGCUGUAAUGGUAA	UUACCAUUACAGCAUCUCU		[110-128]
					210	GACUUACCAGGAAGCAGAU	AUCUGCUUCCUGGUAAGUC		[2115-2133]
211	AGAAGAUCAUAAAGGAAUU	AAUUCCUUUAUGAUCUUCU		[366-384]
					212	CCUGAAAGUCCCAGAUUUU	AAAAUCUGGGACUUUCAGG		[878-896]
213	CAGUGACAGUAUUUUGGUU	AACCAAAAUACUGUCACUG		[3378-3396]
					214	CCUGAGGACGUGGAGAAAA	UUUUCUCCACGUCCUCAGG		[143-161]
215	GAAGCAGAUACAUAUGAGU	ACUCAUAUGUAUCUGCUUC		[2125-2143]
					216	GGUGGAAGUACGUUAUUGU	ACAAUAACGUACUUCCACC		[3249-3267]
217	CCUCCCUUGGGUUCUGAUA	UAUCAGAACCCAAGGGAGG		[2040-2058]
					218	GGAGCCUACGUUUUUAUUA	UAAUAAAAACGUAGGCUCC		[1544-1562]
219	CACCCUUUGCGGAGAUUAU	AUAAUCUCCGCAAAGGGUG		[65-83]
					220	ACCAGGAAGCAGAUACAUA	UAUGUAUCUGCUUCCUGGU		[2120-2138]
221	CUUCCUGCUAUCCUACAAA	UUUGUAGGAUAGCAGGAAG		[839-857]

222	AGGCGCAAUUCAAUGCUGA	UCAGCAUUGAAUUGCGCCU		[530-548]
					223	CCCUGAAAGUCCCAGAUUU	AAAUCUGGGACUUUCAGGG		[877-895]
224	CGGUUGAAAUGCUGAUCCU	AGGAUCAGCAUUUCAACCG	大鼠	[609-627]
					225	CCAGGAGAUGAAAGAUGAG	CUCAUCUUUCAUCUCCUGG		[979-997]
226	GGGUGUGGUUAAUACUAUC	GAUAGUAUUAACCACACCC		[1195-1213]
					227	GAGCUUUUUUCUUUAAGAU	AUCUUAAAGAAAAAAGCUC		[2622-2640]
228	GAGAAAGUGAUUUCUAGAA	UUCUAGAAAUCACUUUCUC		[2746-2764]
					229	GGAGAUGAAAGAUGAGAGU	ACUCUCAUCUUUCAUCUCC		[982-1000]
230	GGGUUCUGAUAUUGCCGCA	UGCGGCAAUAUCAGAACCC		[2048-2066]
					231	ACAGAAAAGAAGAGGAGAA	UUCUCCUCUUCUUUUCUGU		[906-924]
232	GUCAUAUACCUAUAUAAUA	UAUUAUAUAGGUAUAUGAC		[2584-2602]
					233	CCGACAGCCCAUCAUCAUU	AAUGAUGAUGGGCUGUCGG		[1060-1078]
234	AAUCUAGGAUUAUUAACUA	UAGUUAAUAAUCCUAGAUU		[2667-2685]
					235	GGCUAUCUUGGUCUUUGUA	UACAAAGACCAAGAUAGCC		[1366-1384]
236	CUCUGGUUCUUUGUUUUAA	UUAAAACAAAGAACCAGAG		[3894-3912]
					237	ACCUCAGACUUACCAGGAA	UUCCUGGUAAGUCUGAGGU		[2109-2127]
238	CUGGGUGGAAGUACGUUAU	AUAACGUACUUCCACCCAG		[3246-3264]
					239	GAGUCAAUGUGCAGUGUAG	CUACACUGCACAUUGACUC		[3184-3202]
240	GAAUGUUUAUAGCAAACUU	AAGUUUGCUAUAAACAUUC		[2987-3005]
					241	GUUUAUAGCAAACUUGGAA	UUCCAAGUUUGCUAUAAAC		[2991-3009]
242	GCUACUGAUUUCCUUUGGA	UCCAAAGGAAAUCAGUAGC		[2605-2623]
					243	AAAGAAGAGGAGAAUGCUA	UAGCAUUCUCCUCUUCUUU		[911-929]
244	GCUGUAAUGGUAAGACUUU	AAAGUCUUACCAUUACAGC		[116-134]
					245	CCAAUAAACCAGGUUUAGA	UCUAAACCUGGUUUAUUGG		[3159-3177]
246	CCACCAAUGUCUAAGUCGU	ACGACUUAGACAUUGGUGG		[1740-1758]
					247	UUCUAUUACUCAACAGGAA	UUCCUGUUGAGUAAUAGAA	Ms	[1127-1145]
248	CAAAGUGCAGCCCUUCCAU	AUGGAAGGGCUGCACUUUG		[854-872]

249	UAGUAGUACUUGAAAUCUA	UAGAUUUCAAGUACUACUA		[2654-2672]
					250	UCAUAAAGGAAUUUAUCAA	UUGAUAAAUUCCUUUAUGA		[372-390]
251	AGACAUCCAGGAGAUGAAA	UUUCAUCUCCUGGAUGUCU		[973-991]
					252	AGAAAGUGAUUUCUAGAAA	UUUCUAGAAAUCACUUUCU		[2747-2765]
253	CUACAAUCGGCUCUUUCCA	UGGAAAGAGCCGAUUGUAG		[312-330]
					254	UUUCCAUAUGGAUUUUCUA	UAGAAAAUCCAUAUGGAAA		[3869-3887]
255	GGAGAGGAUUUUUUUCUGA	UCAGAAAAAAAUCCUCUCC		[3028-3046]
					256	UGUUUAUAGCAAACUUGGA	UCCAAGUUUGCUAUAAACA		[2990-3008]
257	GGUUUGUUGGAUCUUCAAU	AUUGAAGAUCCAACAAACC		[1906-1924]
					258	GGAUGCAGGUGUUCAAGAG	CUCUUGAACACCUGCAUCC		[1153-1171]
259	GAAAAAGCUGUUUCUGGAA	UUCCAGAAACAGCUUUUUC		[201-219]
					260	GCAUAUGAUAGGCCUUGGA	UCCAAGGCCUAUCAUAUGC		[1264-1282]
261	UAAAAAUUCUGAAUGUACA	UGUACAUUCAGAAUUUUUA		[3915-3933]
					262	CCUUCCAUUUUGCCCUGAA	UUCAGGGCAAAAUGGAAGG		[865-883]
263	UUUUGCUCAUUAACAGAAA	UUUCUGUUAAUGAGCAAAA		[894-912]
					264	UAAGGAGACCACCACCAAU	AUUGGUGGUGGUCUCCUUA		[1729-1747]
265	CACUGUAGUUUCUCUAUUU	AAAUAGAGAAACUACAGUG		[1216-1234]
					266	AUCCAAAUAAGAAACCUAA	UUAGGUUUCUUAUUUGGAU		[2856-2874]
267	CCAUGUACAUUGGAGAGAU	AUCUCUCCAAUGUACAUGG		[678-696]
					268	AAAGAGAGGUUAUAGAGUA	UACUCUAUAACCUCUCUUU		[2411-2429]
269	AGGAGAUUUUAGGUGUUGA	UCAACACCUAAAAUCUCCU		[2923-2941]
					270	AGCAAACUUGGAAUUUGUA	UACAAAUUCCAAGUUUGCU		[2997-3015]
271	UCCUGAGGACGUGGAGAAA	UUUCUCCACGUCCUCAGGA		[142-160]
					272	GAAGCCGGAGGGUGUUUAU	AUAAACACCCUCCGGCUUC		[2147-2165]
273	ACGUUAUUGUUGACUUAUU	AAUAAGUCAACAAUAACGU		[3258-3276]
					274	AUGAAAGAUGAGAGUGCAA	UUGCACUCUCAUCUUUCAU		[986-1004]
275	UUCUGAUAUUGCCGCACUA	UAGUGCGGCAAUAUCAGAA		[2051-2069]

276	CAAGUGUGCUUUAGCUUGA	UCAAGCUAAAGCACACUUG		[3753-3771]
					277	UCCUGGAGCCUUUGAAUAA	UUAUUCAAAGGCUCCAGGA		[3421-3439]
278	GUGAAUAUUUCCAUAUGGA	UCCAUAUGGAAAUAUUCAC		[3862-3880]
					279	AGAGAAAGUGAUUUCUAGA	UCUAGAAAUCACUUUCUCU		[2745-2763]
280	AAGGAUAACUAUAAUGGGA	UCCCAUUAUAGUUAUCCUU		[1328-1346]
					281	UGCUCAUUAACAGAAAAGA	UCUUUUCUGUUAAUGAGCA		[897-915]
282	GAGAAAACUUGCUGCUGAG	CUCAGCAGCAAGUUUUCUC		[155-173]
					283	GCUUCUGAAUGCUGCUACU	AGUAGCAGCAUUCAGAAGC		[1841-1859]
284	CCAUCAUCAUUUCCAUUGU	ACAAUGGAAAUGAUGAUGG		[1068-1086]
					285	AGUCAUGAUCCCAGCGAGA	UCUCGCUGGGAUCAUGACU		[88-106]
286	CAAAUAAGAAACCUAAAAU	AUUUUAGGUUUCUUAUUUG		[2859-2877]
					287	GACUGUUUCUUUGUUAUUA	UAAUAACAAAGAAACAGUC		[1309-1327]
288	UGUUCAAGAGCCCAUCUAU	AUAGAUGGGCUCUUGAACA		[1162-1180]
					289	CAUGACUGUUUCUUUGUUA	UAACAAAGAAACAGUCAUG		[1306-1324]
290	UAUAGGAGAGGAAAAGUAA	UUACUUUUCCUCUCCUAUA		[2075-2093]
					291	AGAUUUUUGCUCAUUAACA	UGUUAAUGAGCAAAAAUCU		[890-908]
292	CCACACUUGAGAGGAUGAA	UUCAUCCUCUCAAGUGUGG		[3204-3222]
					293	GGAAUUUAUCAAUAAAACU	AGUUUUAUUGAUAAAUUCC		[379-397]
294	GCACCUUCCUCACUUCCAU	AUGGAAGUGAGGAAGGUGC		[2172-2190]
					295	UACCGACAGCCCAUCAUCA	UGAUGAUGGGCUGUCGGUA		[1058-1076]
296	ACUGUGGUCCUAUGCCGAA	UUCGGCAUAGGACCACAGU		[3116-3134]
					297	GGUUUUGUGCCCAUGUACA	UGUACAUGGGCACAAAACC		[668-686]
298	GGUUAUAGAGUAGAAGAUU	AAUCUUCUACUCUAUAACC		[2418-2436]
					299	UAAUGGUAAGACUUUGGAU	AUCCAAAGUCUUACCAUUA		[120-138]
300	UGCAAGGAUGUCACAAGAA	UUCUUGUGACAUCCUUGCA		[1000-1018]
					301	GCGUCAUGGAGAUGAACAG	CUGUUCAUCUCCAUGACGC		[1698-1716]
302	CUGUUGUAUUUUAACUCAU	AUGAGUUAAAAUACAACAG		[2946-2964]

303	AGAGGAAAAGUAAGGUGCA	UGCACCUUACUUUUCCUCU		[2081-2099]
					304	UAUGGAUUUUCUAUUGUUA	UAACAAUAGAAAAUCCAUA		[3875-3893]
305	UGCGGAGAUUAUAAAUAGU	ACUAUUUAUAAUCUCCGCA		[72-90]
					306	GACUCUUCGUCAACCGCUU	AAGCGGUUGACGAAGAGUC		[507-525]
307	CAGGAAGCAGAUACAUAUG	CAUAUGUAUCUGCUUCCUG		[2122-2140]
					308	GAGGAGAAUGCUAAGCAGA	UCUGCUUAGCAUUCUCCUC		[917-935]
309	GGGUAUGAUCGGCUCCUUU	AAAGGAGCCGAUCAUACCC		[481-499]
					310	UUACCAGGAAGCAGAUACA	UGUAUCUGCUUCCUGGUAA		[2118-2136]
311	GUAAUGGUAAGACUUUGGA	UCCAAAGUCUUACCAUUAC		[119-137]
					312	CUUCAAGGAUGCAGGUGUU	AACACCUGCAUCCUUGAAG		[1147-1165]
313	UACUCAACAGGAAUCUUCA	UGAAGAUUCCUGUUGAGUA	Ms	[1133-1151]
					314	AAGAAGAGGAGAAUGCUAA	UUAGCAUUCUCCUCUUCUU		[912-930]
315	AGUCGGUUGAAAUGCUGAU	AUCAGCAUUUCAACCGACU	大鼠	[606-624]
					316	GACUUGAAUCUUUCCAAUA	UAUUGGAAAGAUUCAAGUC		[3146-3164]
317	UCACUGAGAAGAUUGUGAA	UUCACAAUCUUCUCAGUGA		[3848-3866]
					318	AGGAGAAUGCUAAGCAGAU	AUCUGCUUAGCAUUCUCCU		[918-936]
319	GAGUGCAAGGAUGUCACAA	UUGUGACAUCCUUGCACUC		[997-1015]
					320	AAAGCAAGUCACCGUGCUA	UAGCACGGUGACUUGCUUU		[1018-1036]
321	CAUCAGGAUGAACCCAGGA	UCCUGGGUUCAUCCUGAUG		[1821-1839]
					322	UAUCACACGGGCCUUUGAA	UUCAAAGGCCCGUGUGAUA		[1642-1660]
323	GACAGUAUUUUGGUUCUUA	UAAGAACCAAAAUACUGUC		[3382-3400]
					324	GAAAGUGAUUUCUAGAAAG	CUUUCUAGAAAUCACUUUC		[2748-2766]
325	AGACUUGAAUUAGAUUACA	UGUAAUCUAAUUCAAGUCU		[241-259]
					326	AGUCAUAUACCUAUAUAAU	AUUAUAUAGGUAUAUGACU		[2583-2601]
327	UGUUCUUUAGGAGAUUUUA	UAAAAUCUCCUAAAGAACA		[2915-2933]
					328	UAGCUAAGUCGGUUGAAAU	AUUUCAACCGACUUAGCUA		[600-618]
329	CAAUAAGAAUUUAGGGAGA	UCUCCCUAAAUUCUUAUUG		[2459-2477]

330	GUGGAAGUACGUUAUUGUU	AACAAUAACGUACUUCCAC		[3250-3268]
					331	AGAGUGCAAGGAUGUCACA	UGUGACAUCCUUGCACUCU		[996-1014]
332	AAUGCUCCUGAGAAGAUCA	UGAUCUUCUCAGGAGCAUU		[356-374]
					333	AGAGGAGAAUGCUAAGCAG	CUGCUUAGCAUUCUCCUCU		[916-934]
334	UGCUCCUGGAGCCUUUGAA	UUCAAAGGCUCCAGGAGCA		[3418-3436]
					335	CAUUAUUUUUCCACUUUGU	ACAAAGUGGAAAAAUAAUG		[2899-2917]
336	AGACUUACCAGGAAGCAGA	UCUGCUUCCUGGUAAGUCU		[2114-2132]
					337	GAUUUUUGCUCAUUAACAG	CUGUUAAUGAGCAAAAAUC		[891-909]
338	UGCUGAUUGUCAACCUGUU	AACAGGUUGACAAUCAGCA		[543-561]
					339	AACUCAUACCUUUAAAGGA	UCCUUUAAAGGUAUGAGUU		[2958-2976]
340	CCAACUUCCUAGUCGGAUU	AAUCCGACUAGGAAGUUGG		[1497-1515]
					341	CUGGAGAGGUUAAGGUGCA	UGCACCUUAACCUCUCCAG		[2442-2460]
342	AAGGCUGCGGUUUGUUGGA	UCCAACAAACCGCAGCCUU		[1898-1916]
					343	GUCCCAGAUUUUUGCUCAU	AUGAGCAAAAAUCUGGGAC		[885-903]
344	UCAUUAACAGAAAAGAAGA	UCUUCUUUUCUGUUAAUGA		[900-918]
					345	UCCCAUUUCUCACUGAGAA	UUCUCAGUGAGAAAUGGGA		[3839-3857]
346	GAAAACUUGCUGCUGAGAA	UUCUCAGCAGCAAGUUUUC		[157-175]
					347	CAGAAAAGAAGAGGAGAAU	AUUCUCCUCUUCUUUUCUG		[907-925]
348	GGCGUCAUGGAGAUGAACA	UGUUCAUCUCCAUGACGCC		[1697-1715]
					349	GGUUGAUGGGUUCUAAUUU	AAAUUAGAACCCAUCAACC		[2709-2727]
350	AACUAAUAUGGGCAUUGUA	UACAAUGCCCAUAUUAGUU		[2681-2699]
					351	GAAUUUAGGGAGAAAUGUU	AACAUUUCUCCCUAAAUUC		[2465-2483]
352	AGUAGUACUUGAAAUCUAG	CUAGAUUUCAAGUACUACU		[2655-2673]
					353	UCCAGGAGAUGAAAGAUGA	UCAUCUUUCAUCUCCUGGA		[978-996]
354	ACCGACAGCCCAUCAUCAU	AUGAUGAUGGGCUGUCGGU		[1059-1077]
					355	AGUGUGCUUUAGCUUGAAA	UUUCAAGCUAAAGCACACU		[3755-3773]
356	GCUUUUUGUUCCACGCUCA	UGAGCGUGGAACAAAAAGC		[1289-1307]

357	AUAUAAUAAAGCUACUGAU	AUCAGUAGCUUUAUUAUAU		[2595-2613]
					358	UGUUAUUAAAGGAUAACUA	UAGUUAUCCUUUAAUAACA		[1320-1338]
359	GGAGAUGAACAGCAUCGAG	CUCGAUGCUGUUCAUCUCC		[1705-1723]
					360	ACUCUUUAACUUCUCGUAA	UUACGAGAAGUUAAAGAGU		[2563-2581]
361	CUGCUACUGGGUUUUACCA	UGGUAAAACCCAGUAGCAG		[818-836]
					362	AGGAAGCAGAUACAUAUGA	UCAUAUGUAUCUGCUUCCU		[2123-2141]
363	GUUCUAUUACUCAACAGGA	UCCUGUUGAGUAAUAGAAC	Ms	[1126-1144]
					364	CAAUUUCUGUCCUUCAGAU	AUCUGAAGGACAGAAAUUG		[2540-2558]
365	CUGUGGUCCUAUGCCGAAU	AUUCGGCAUAGGACCACAG		[3117-3135]
					366	CUACUUAAUUCCUUUCUCA	UGAGAAAGGAAUUAAGUAG		[1855-1873]
367	AAGGACUCUGCAUAUGAUA	UAUCAUAUGCAGAGUCCUU		[1255-1273]
					368	UGCUGUAAUGGUAAGACUU	AAGUCUUACCAUUACAGCA		[115-133]
369	CAAUGUGCAGUGUAGCCCA	UGGGCUACACUGCACAUUG		[3188-3206]
					370	AGGUUAUAGAGUAGAAGAU	AUCUUCUACUCUAUAACCU		[2417-2435]
371	CCUAUAUAAUAAAGCUACU	AGUAGCUUUAUUAUAUAGG		[2592-2610]
					372	CCACCACCAAUGUCUAAGU	ACUUAGACAUUGGUGGUGG		[1737-1755]
373	AUAUGGGCAUUGUAGUUAA	UUAACUACAAUGCCCAUAU		[2686-2704]
					374	AGCUAUCAAGUGUGCUUUA	UAAAGCACACUUGAUAGCU		[3747-3765]
375	AUCUAGGAUUAUUAACUAA	UUAGUUAAUAAUCCUAGAU		[2668-2686]
					376	AAACCAGGUUUAGACAGUA	UACUGUCUAAACCUGGUUU		[3164-3182]
377	GAACCUACCUUCAUUUCAG	CUGAAAUGAAGGUAGGUUC		[1979-1997]
					378	GGACAUCCUCUUCUGCUUA	UAAGCAGAAGAGGAUGUCC		[1947-1965]
379	CGCUUGCGUAUGUCUGUUA	UAACAGACAUACGCAAGCG		[3090-3108]
					380	GGCUGAAAAAGCUGUUUCU	AGAAACAGCUUUUUCAGCC		[197-215]
381	CGGACUCUGCACAGGUUUU	AAAACCUGUGCAGAGUCCG		[655-673]
					382	GAGGUUAAGGUGCAAUAAG	CUUAUUGCACCUUAACCUC		[2447-2465]
383	AGAAGGACUCUGCAUAUGA	UCAUAUGCAGAGUCCUUCU		[1253-1271]

384	UGAAAAGGUGACCUUGCAA	UUGCAAGGUCACCUUUUCA		[3769-3787]
					385	ACAUUUUGAAGGUUUUGUU	AACAAAACCUUCAAAAUGU		[178-196]
386	CUCCUGGAGCCUUUGAAUA	UAUUCAAAGGCUCCAGGAG		[3420-3438]
					387	UGAAAAAGCUGUUUCUGGA	UCCAGAAACAGCUUUUUCA		[200-218]
388	GGGAUGAGCUUUGUCUGUA	UACAGACAAAGCUCAUCCC		[1343-1361]
					389	UCUCAUUACUUUUGAAGUA	UACUUCAAAAGUAAUGAGA		[2809-2827]
390	UAGCAAACUUGGAAUUUGU	ACAAAUUCCAAGUUUGCUA		[2996-3014]
					391	GGAUGAAAUAACUCCUUCU	AGAAGGAGUUAUUUCAUCC		[2782-2800]
392	CAAGGGAGAGACCUCAUCA	UGAUGAGGUCUCUCCCUUG		[1807-1825]
					393	CUCUAUUUCUGGUGGAAAG	CUUUCCACCAGAAAUAGAG		[1227-1245]
394	UGGAGAUGAACAGCAUCGA	UCGAUGCUGUUCAUCUCCA		[1704-1722]
					395	CUGAGGACGUGGAGAAAAC	GUUUUCUCCACGUCCUCAG		[144-162]
396	CAUUGUAGUUAAUGAUGGU	ACCAUCAUUAACUACAAUG		[2693-2711]
					397	GAGGGAGGUGUUUAAAGAG	CUCUUUAAACACCUCCCUC	Ms	[2398-2416]
398	CUCAUUACUUUUGAAGUAA	UUACUUCAAAAGUAAUGAG		[2810-2828]
					399	UAGAAGAUUUGAUGCUGGA	UCCAGCAUCAAAUCUUCUA		[2428-2446]
400	AGGAGACCACCACCAAUGU	ACAUUGGUGGUGGUCUCCU		[1731-1749]
					401	CAGAUAGAUCUGGAAAGGA	UCCUUUCCAGAUCUAUCUG		[1677-1695]
402	CUGAAUGCUGCUACUUAAU	AUUAAGUAGCAGCAUUCAG		[1845-1863]
					403	GAGAUUCAUUAUUUUUCCA	UGGAAAAAUAAUGAAUCUC		[2893-2911]
404	GCAAUUCAAUGCUGAUUGU	ACAAUCAGCAUUGAAUUGC		[534-552]
					405	CUAAGUCGGUUGAAAUGCU	AGCAUUUCAACCGACUUAG		[603-621]
406	CUUUCUUGAAGACUUGAAU	AUUCAAGUCUUCAAGAAAG		[232-250]
					407	ACCCAGGACGCUUCUGAAU	AUUCAGAAGCGUCCUGGGU		[1832-1850]
408	GAAGAUUUGAUGCUGGAGA	UCUCCAGCAUCAAAUCUUC		[2430-2448]
					409	UGGUAGAGAUUCAUUAUUU	AAAUAAUGAAUCUCUACCA		[2888-2906]
410	UAUAGAGUAGAAGAUUUGA	UCAAAUCUUCUACUCUAUA		[2421-2439]

411	GUGUUUAAAGAGAGGUUAU	AUAACCUCUCUUUAAACAC		[2405-2423]
					412	GUUAUUAAAGGAUAACUAU	AUAGUUAUCCUUUAAUAAC		[1321-1339]
413	UGUUGAUUUUCUGUUGUAU	AUACAACAGAAAAUCAACA		[2936-2954]
					414	CCCUUGUCAGUGACAGUAU	AUACUGUCACUGACAAGGG		[3371-3389]
415	CACUUGAGAGGAUGAAUGU	ACAUUCAUCCUCUCAAGUG		[3207-3225]
					416	GGUCUGUACGUUACCUCUU	AAGAGGUAACGUACAGACC		[2519-2537]
417	GGACCUCCAACUUCCUAGU	ACUAGGAAGUUGGAGGUCC		[1491-1509]
					418	GGUUAAUACUAUCUUCACU	AGUGAAGAUAGUAUUAACC		[1201-1219]
419	GAGAGACCGAGUGAACCUA	UAGGUUCACUCGGUCUCUC		[1967-1985]
					420	CUCAUACCUUUAAAGGAAU	AUUCCUUUAAAGGUAUGAG		[2960-2978]
421	ACUUCUCGUAAAAGUCAUA	UAUGACUUUUACGAGAAGU		[2571-2589]
					422	GGGUCCCAUUUCUCACUGA	UCAGUGAGAAAUGGGACCC		[3836-3854]
423	UGAGCGAUUAUUAUCUAAA	UUUAGAUAAUAAUCGCUCA		[3044-3062]
					424	GAAGACUUGAAUUAGAUUA	UAAUCUAAUUCAAGUCUUC		[239-257]
425	GUUGAUGGGUUCUAAUUUU	AAAAUUAGAACCCAUCAAC		[2710-2728]
					426	CGACAGCCCAUCAUCAUUU	AAAUGAUGAUGGGCUGUCG		[1061-1079]
427	AGAUGAGAGUGCAAGGAUG	CAUCCUUGCACUCUCAUCU		[991-1009]
					428	GCAUCGUUGUUGGAAUUCU	AGAAUUCCAACAACGAUGC		[744-762]
429	CCGUGCUAGAGCUCUUUAG	CUAAAGAGCUCUAGCACGG		[1029-1047]
					430	CACGCUUGCGUAUGUCUGU	ACAGACAUACGCAAGCGUG		[3088-3106]
431	AGGAUGCAGGUGUUCAAGA	UCUUGAACACCUGCAUCCU		[1152-1170]
					432	GGUAAGACUUUGGAUCCUU	AAGGAUCCAAAGUCUUACC		[124-142]
433	CACUUUGCUCUGGGUGGAA	UUCCACCCAGAGCAAAGUG		[3237-3255]
					434	AUAAAACUUUGACGGACAA	UUGUCCGUCAAAGUUUUAU		[390-408]
435	GGUUCUUAGUUCUCACUGU	ACAGUGAGAACUAAGAACC		[3393-3411]
					436	GGUGACCUUGCAACUUCAU	AUGAAGUUGCAAGGUCACC		[3775-3793]
437	GUUAUAGAGUAGAAGAUUU	AAAUCUUCUACUCUAUAAC		[2419-2437]

438	GGACGUGGAGAAAACUUGC	GCAAGUUUUCUCCACGUCC		[148-166]
					439	UUGGAUGGAGUCCAGGGAA	UUCCCUGGACUCCAUCCAA		[2727-2745]
440	CAAUCGGCUCUUUCCAAUU	AAUUGGAAAGAGCCGAUUG		[315-333]
					441	CCGCUGCUACUGGGUUUUA	UAAAACCCAGUAGCAGCGG		[815-833]
442	CGCUGCUACUGGGUUUUAC	GUAAAACCCAGUAGCAGCG		[816-834]
					443	GACCCAGAGAUGCUGUAAU	AUUACAGCAUCUCUGGGUC		[105-123]
444	GAGGGUAAAUGAUGUGGUG	CACCACAUCAUUUACCCUC		[2495-2513]
					445	GUAGUCUCAUUACUUUUGA	UCAAAAGUAAUGAGACUAC		[2805-2823]
446	CCAACUGGACCUCCAACUU	AAGUUGGAGGUCCAGUUGG		[1485-1503]
					447	CCUUCUUCAAAGUCCCUGA	UCAGGGACUUUGAAGAAGG		[1599-1617]
448	UCCCUUGGGUUCUGAUAUU	AAUAUCAGAACCCAAGGGA		[2042-2060]
					449	UCAUUACUUUUGAAGUAAU	AUUACUUCAAAAGUAAUGA		[2811-2829]
450	CCCAAGACAUCCAGGAGAU	AUCUCCUGGAUGUCUUGGG		[969-987]
					451	GUUGAUUUUCUGUUGUAUU	AAUACAACAGAAAAUCAAC		[2937-2955]
452	AAGGUGCAAUAAGAAUUUA	UAAAUUCUUAUUGCACCUU		[2453-2471]
					453	UGAAUUAGAUUACAGCGAU	AUCGCUGUAAUCUAAUUCA		[246-264]
454	GGAUGAAUGUAUGUGCACU	AGUGCACAUACAUUCAUCC		[3216-3234]
					455	AUAAGAAUUUAGGGAGAAA	UUUCUCCCUAAAUUCUUAU		[2461-2479]
456	UGCUCCUGAGAAGAUCAUA	UAUGAUCUUCUCAGGAGCA		[358-376]
					457	GAAAGAUGAGAGUGCAAGG	CCUUGCACUCUCAUCUUUC		[988-1006]
458	ACUUGAGAGGAUGAAUGUA	UACAUUCAUCCUCUCAAGU		[3208-3226]
					459	UUUAACUCAUACCUUUAAA	UUUAAAGGUAUGAGUUAAA		[2955-2973]
460	AGAAGAGGAGAAUGCUAAG	CUUAGCAUUCUCCUCUUCU		[913-931]
					461	UGUUUAAAGAGAGGUUAUA	UAUAACCUCUCUUUAAACA		[2406-2424]
462	UUGAAGACUUGAAUUAGAU	AUCUAAUUCAAGUCUUCAA		[237-255]
					463	GUGCAGAUAGAUCUGGAAA	UUUCCAGAUCUAUCUGCAC		[1674-1692]
464	UACAAUCGGCUCUUUCCAA	UUGGAAAGAGCCGAUUGUA		[313-331]

465	CAUAAAGGAAUUUAUCAAU	AUUGAUAAAUUCCUUUAUG		[373-391]
					466	CAGGAGAUGAAAGAUGAGA	UCUCAUCUUUCAUCUCCUG		[980-998]
467	UCUUUGGUCUGGAAUUCAU	AUGAAUUCCAGACCAAAGA		[774-792]
					468	UACGUUACCUCUUAACAAU	AUUGUUAAGAGGUAACGUA		[2525-2543]
469	AUUGGUUCUUGGUAGAGAU	AUCUCUACCAAGAACCAAU		[2879-2897]
					470	AGGUCUGUACGUUACCUCU	AGAGGUAACGUACAGACCU		[2518-2536]
471	GAGAGUGCAAGGAUGUCAC	GUGACAUCCUUGCACUCUC		[995-1013]
					472	AAAGUCAUAUACCUAUAUA	UAUAUAGGUAUAUGACUUU		[2581-2599]
473	UGAGAAGAUUGUGAAUAUU	AAUAUUCACAAUCUUCUCA		[3852-3870]
					474	ACAGUAUUUUGGUUCUUAG	CUAAGAACCAAAAUACUGU		[3383-3401]
475	GGAGGGUAAAUGAUGUGGU	ACCACAUCAUUUACCCUCC		[2494-2512]
					476	CACACUUGAGAGGAUGAAU	AUUCAUCCUCUCAAGUGUG		[3205-3223]
477	GAGGACGUGGAGAAAACUU	AAGUUUUCUCCACGUCCUC		[146-164]
					478	CUCCAACUUCCUAGUCGGA	UCCGACUAGGAAGUUGGAG		[1495-1513]
479	GCGUAUGUCUGUUACCAUG	CAUGGUAACAGACAUACGC		[3095-3113]
					480	UCAUGGAGAUGAACAGCAU	AUGCUGUUCAUCUCCAUGA		[1701-1719]
481	GGCAGGACUUUUGAGGAUA	UAUCCUCAAAAGUCCUGCC		[1625-1643]
					482	CUCCCUUGGGUUCUGAUAU	AUAUCAGAACCCAAGGGAG		[2041-2059]
483	AUAUCACACGGGCCUUUGA	UCAAAGGCCCGUGUGAUAU		[1641-1659]
					484	GGGAGGUGUUUAAAGAGAG	CUCUCUUUAAACACCUCCC	Ms	[2400-2418]
485	GGUCUUUGUAGCCUUCUUU	AAAGAAGGCUACAAAGACC		[1375-1393]
					486	UUAGGAGCCUACGUUUUUA	UAAAAACGUAGGCUCCUAA	Ms	[1541-1559]
487	AAUGUUGUUCAUUAUUGGA	UCCAAUAAUGAACAACAUU		[2478-2496]
					488	GGUGUUUAAAGAGAGGUUA	UAACCUCUCUUUAAACACC		[2404-2422]
489	AGGAAUUUAUCAAUAAAAC	GUUUUAUUGAUAAAUUCCU		[378-396]
					490	AGGGAGGUGUUUAAAGAGA	UCUCUUUAAACACCUCCCU	Ms	[2399-2417]
491	UGGUCUUUGUAGCCUUCUU	AAGAAGGCUACAAAGACCA		[1374-1392]

492	AGCUUUUUUCUUUAAGAUA	UAUCUUAAAGAAAAAAGCU		[2623-2641]
					493	UUGAAAUCUAGGAUUAUUA	UAAUAAUCCUAGAUUUCAA		[2663-2681]
494	UAGGGAGAAAUGUUGUUCA	UGAACAACAUUUCUCCCUA		[2470-2488]
					495	GUAGUAGUCUCAUUACUUU	AAAGUAAUGAGACUACUAC		[2802-2820]
496	CCUACAAAGUGCAGCCCUU	AAGGGCUGCACUUUGUAGG		[850-868]
					497	AGAAGGAAAUUGAGAUUAG	CUAAUCUCAAUUUCCUUCU		[2380-2398]
498	CUUGAAAUCUAGGAUUAUU	AAUAAUCCUAGAUUUCAAG		[2662-2680]
					499	CGGAGGGUGUUUAUGUAAG	CUUACAUAAACACCCUCCG		[2152-2170]
500	CAGCCCAUCAUCAUUUCCA	UGGAAAUGAUGAUGGGCUG		[1064-1082]

表B 31SLC5A1-溶质载体家族5，成员1

No.	正义链siRNA	反义链siRNA	其他Sp	人-4507030：11-2005
					1	GGACAGUGUUGAACGUCAA	UUGACGUUCAACACUGUCC		[1935-1953]
2	GGGCUAUGUUUUCCACCAA	UUGGUGGAAAACAUAGCCC	Chmp	[144-162]
					3	CCAGAAAAAGGCAGACUAA	UUAGUCUGCCUUUUUCUGG		[2253-2271]
4	UAGGCUAGCUGGAAGAAAA	UUUUCUUCCAGCUAGCCUA	Chmp	[2140-2158]
					5	UGUGGAGGACAGUGUUGAA	UUCAACACUGUCCUCCACA		[1929-1947]
6	GGAGACCAUUGAAAUAGAA	UUCUAUUUCAAUGGUCUCC		[1765-1783]
					7	GUGUCAGUGUGGUUUAUAA	UUAUAAACCACACUGACAC		[2328-2346]
8	GGAAGAGGAGAACAUCCAA	UUGGAUGUUCUCCUCUUCC	Chmp	[1735-1753]
					9	GGUUUAUAAUCCUUGAAUA	UAUUCAAGGAUUAUAAACC		[2338-2356]
10	CUGUGGUGUUGAAGGGAAA	UUUCCCUUCAACACCACAG	Chmp	[2069-2087]
					11	CGAGCUCAUUCGCAAUGCA	UGCAUUGCGAAUGAGCUCG	Chmp	[70-88]
12	CAUGGAAAAGUACAUGAAA	UUUCAUGUACUUUUCCAUG	Chmp	[706-724]
					13	CUUGAAUAUUGUUUUAGAA	UUCUAAAACAAUAUUCAAG	Chmp	[2349-2367]
14	CCAUGUGAUUGAUGUCUGA	UCAGACAUCAAUCACAUGG	Chmp	[2282-2300]
					15	CCCUAAGGAGACCAUUGAA	UUCAAUGGUCUCCUUAGGG		[1759-1777]
16	CCAUUAGUUUGCUGUUAAU	AUUAACAGCAAACUAAUGG	Chmp	[2159-2177]

17	CCUUGAAUAUUGUUUUAGA	UCUAAAACAAUAUUCAAGG	Chmp	[2348-2366]
					18	GAAAAAUGCUACACUCCAA	UUGGAGUGUAGCAUUUUUC	Chmp	[767-785]
19	CCCUGACCUCCAUCUUCAA	UUGAAGAUGGAGGUCAGGG	Chmp	[1188-1206]
					20	ACAAGUUCCUGAGAAGAAA	UUUCUUCUCAGGAACUUGU	Chmp	[1786-1804]
21	GUUAAUUUAUGCAUUUGAA	UUCAAAUGCAUAAAUUAAC	Chmp	[2172-2190]
					22	ACGCCUUCAUGGAAAAGUA	UACUUUUCCAUGAAGGCGU	Chmp	[699-717]
23	GGCUAUGUUUUCCACCAAU	AUUGGUGGAAAACAUAGCC	Chmp	[145-163]
					24	GACUGAGGAAGAGGAGAAA	UUUCUCCUCUUCCUCAGUC	Chmp	[1870-1888]
25	CAAGUUCCUGAGAAGAAAA	UUUUCUUCUCAGGAACUUG	Chmp	[1787-1805]
					26	GGCAGACUAAGAAUCAGAA	UUCUGAUUCUUAGUCUGCC		[2262-2280]
27	GAAAAAGGCAGACUAAGAA	UUCUUAGUCUGCCUUUUUC		[2256-2274]
					28	CACUCAGUCACAUCCAGAA	UUCUGGAUGUGACUGAGUG		[2240-2258]
29	GCAAGAGAGCAUCUGAGAA	UUCUCAGAUGCUCUCUUGC	Chmp	[1251-1269]
					30	CCAAGAUCUCGGCAGACAU	AUGUCUGCCGAGAUCUUGG	Chmp	[477-495]
31	CGCAAGAGAGCAUCUGAGA	UCUCAGAUGCUCUCUUGCG	Chmp	[1250-1268]
					32	AGGAGACCAUUGAAAUAGA	UCUAUUUCAAUGGUCUCCU		[1764-1782]
33	CACAAGUUCCUGAGAAGAA	UUCUUCUCAGGAACUUGUG	Chmp	[1785-1803]
					34	CCAAGAUGACUGAGGAAGA	UCUUCCUCAGUCAUCUUGG	Chmp	[1863-1881]
35	CCAUGUUCAUCAUGGUGAU	AUCACCAUGAUGAACAUGG		[981-999]
					36	GCCUGAUGCUAUCAGUCAU	AUGACUGAUAGCAUCAGGC	Chmp	[1149-1167]
37	CAUUGUGCAGUCAGCACAA	UUGUGCUGACUGCACAAUG		[1336-1354]
					38	GGAUGUCCAUCCUUACCUU	AAGGUAAGGAUGGACAUCC	Chmp	[855-873]
39	CUCGUCCUGUGGUGUUGAA	UUCAACACCACAGGACGAG	Chmp	[2063-2081]
					40	CAAGAGAGCAUCUGAGAAA	UUUCUCAGAUGCUCUCUUG	Chmp	[1252-1270]
41	CCUUAGGCCUGAAUCUGUA	UACAGAUUCAGGCCUAAGG	Chmp	[525-543]
					42	AGAGGAGAACAUCCAAGAA	UUCUUGGAUGUUCUCCUCU	Chmp	[1738-1756]
43	UGGGUUUGCUUUUCACGAA	UUCGUGAAAAGCAAACCCA	Chmp	[667-685]

44	UCAUCUCCCUCCUCACCAA	UUGGUGAGGAGGGAGAUGA	大鼠，Chmp	[1638-1656]
					45	ACACCACCUUUCAGGAAAA	UUUUCCUGAAAGGUGGUGU	Chmp	[753-771]
46	CCUGAGAAGAAAAAAGGAA	UUCCUUUUUUCUUCUCAGG	Chmp	[1793-1811]
					47	GGAGGACAGUGUUGAACGU	ACGUUCAACACUGUCCUCC		[1932-1950]
48	GGGCAACUCUUCGAUUACA	UGUAAUCGAAGAGUUGCCC	Chmp	[1358-1376]
					49	CGGGUGUCAGUGUGGUUUA	UAAACCACACUGACACCCG		[2325-2343]
50	GGAGCGUAUUGACCUGGAU	AUCCAGGUCAAUACGCUCC	Chmp	[1714-1732]
					51	CCACGAGCUCAUUCGCAAU	AUUGCGAAUGAGCUCGUGG	Chmp	[67-85]
52	CCAUGCAUAUUUUGCCUGA	UCAGGCAAAAUAUGCAUGG		[1987-2005]
					53	CAGGAGAGCCUAUGACCUA	UAGGUCAUAGGCUCUCCUG	Chmp	[1816-1834]
54	CGGAAGAGGAGAACAUCCA	UGGAUGUUCUCCUCUUCCG	Chmp	[1734-1752]
					55	CUAUGACGCCUUCAUGGAA	UUCCAUGAAGGCGUCAUAG	Chmp	[694-712]
56	CAUCGCCUAUCCAACCUUA	UAAGGUUGGAUAGGCGAUG	Chmp	[1099-1117]
					57	GGGAUUUCACGUAUGAUUA	UAAUCAUACGUGAAAUCCC	Chmp	[1496-1514]
58	GGGUGUCAGUGUGGUUUAU	AUAAACCACACUGACACCC		[2326-2344]
					59	CAGUGUGGUUUAUAAUCCU	AGGAUUAUAAACCACACUG		[2332-2350]
60	CAGCAAAGAGGAGCGUAUU	AAUACGCUCCUCUUUGCUG	Chmp	[1705-1723]
					61	CCUCCCUCUUUGCUAGUAA	UUACUAGCAAAGAGGGAGG	Chmp	[225-243]
62	GGAAGAAAACCAUUAGUUU	AAACUAAUGGUUUUCUUCC	Chmp	[2150-2168]
					63	CUAGCUGGAAGAAAACCAU	AUGGUUUUCUUCCAGCUAG	Chmp	[2144-2162]
64	CCUGUGGUGUUGAAGGGAA	UUCCCUUCAACACCACAGG	Chmp	[2068-2086]
					65	CCUUCAUGGAAAAGUACAU	AUGUACUUUUCCAUGAAGG	Chmp	[702-720]
66	GCCCUAAGGAGACCAUUGA	UCAAUGGUCUCCUUAGGGC		[1758-1776]
					67	CACCCAAGAUGACUGAGGA	UCCUCAGUCAUCUUGGGUG	Chmp	[1860-1878]
68	UGACGGACACCUCUGAGAA	UUCUCAGAGGUGUCCGUCA	Chmp	[1905-1923]
					69	CUGUCUUCCUGCUUGCUAU	AUAGCAAGCAGGAAGACAG	Chmp	[1416-1434]
70	UUAGUUUGCUGUUAAUUUA	UAAAUUAACAGCAAACUAA	Chmp	[2162-2180]

71	GUGGGUAUCUAAAGCUGAU	AUCAGCUUUAGAUACCCAC		[960-978]
					72	UGUGGUUUAUAAUCCUUGA	UCAAGGAUUAUAAACCACA		[2335-2353]
73	AGAAAAAGGCAGACUAAGA	UCUUAGUCUGCCUUUUUCU		[2255-2273]
					74	CGUGAGUCUGUCUCAGGUA	UACCUGAGACAGACUCACG		[2301-2319]
75	UGAUCAGCCGCAUUCUGUA	UACAGAAUGCGGCUGAUCA	Chmp	[1008-1026]
					76	GAGACCAUUGAAAUAGAAA	UUUCUAUUUCAAUGGUCUC		[1766-1784]
77	CCCUCUUCACCAUGGACAU	AUGUCCAUGGUGAAGAGGG		[1218-1236]
					78	UCUCCAUCAUCGUUAUCUA	UAGAUAACGAUGAUGGAGA	Chmp	[96-114]
79	UGCGCAACAGCAAAGAGGA	UCCUCUUUGCUGUUGCGCA	Chmp	[1698-1716]
					80	AGCUGAUGCCCAUGUUCAU	AUGAACAUGGGCAUCAGCU		[972-990]
81	CCUAAGGAGACCAUUGAAA	UUUCAAUGGUCUCCUUAGG		[1760-1778]
					82	GACCAUUGAAAUAGAAACA	UGUUUCUAUUUCAAUGGUC		[1768-1786]
83	CGGACUGUGGGCUAUGUUU	AAACAUAGCCCACAGUCCG	Chmp	[136-154]
					84	CCAUGAAGAUGAAGAUGAC	GUCAUCUUCAUCUUCAUGG	Ms，Chmp	[1890-1908]
85	GGAAAAAUGCUACACUCCA	UGGAGUGUAGCAUUUUUCC	Chmp	[766-784]
					86	CUGAGAAAGAGCUCAUGAU	AUCAUGAGCUCUUUCUCAG	Chmp	[1263-1281]
87	CAAUCGUGGGACUGUUGGA	UCCAACAGUCCCACGAUUG		[160-178]
					88	CACCAAACCCAUUCCGGAU	AUCCGGAAUGGGUUUGGUG	Chmp	[1651-1669]
89	CACCACCUUUCAGGAAAAA	UUUUUCCUGAAAGGUGGUG	Chmp	[754-772]
					90	CUGGGUUCAUCUUUGGGAU	AUCCCAAAGAUGAACCCAG	Chmp	[840-858]
91	GAGUCUGUCUCAGGUAGAU	AUCUACCUGAGACAGACUC	Chmp	[2304-2322]
					92	CCUCUUUGCUAGUAACAUU	AAUGUUACUAGCAAAGAGG	Chmp	[229-247]
93	UCAGUCACAUCCAGAAAAA	UUUUUCUGGAUGUGACUGA	Chmp	[2243-2261]
					94	AGUUCCUGAGAAGAAAAAA	UUUUUUCUUCUCAGGAACU	Chmp	[1789-1807]
95	CAUCUCCCUCCUCACCAAA	UUUGGUGAGGAGGGAGAUG	Chmp	[1639-1657]
					96	GGCAACUCUUCGAUUACAU	AUGUAAUCGAAGAGUUGCC	Chmp	[1359-1377]
97	CCAUCAUCGUUAUCUACUU	AAGUAGAUAACGAUGAUGG	Chmp	[99-117]

98	UCACCAAACCCAUUCCGGA	UCCGGAAUGGGUUUGGUGA	Chmp	[1650-1668]
					99	GAGGCUAUGACGCCUUCAU	AUGAAGGCGUCAUAGCCUC	Chmp	[690-708]
100	CCGGAAGGUUGUUUAUCCU	AGGAUAAACAACCUUCCGG	Chmp	[1284-1302]
					101	UAAGGAGACCAUUGAAAUA	UAUUUCAAUGGUCUCCUUA		[1762-1780]
102	CUUUGCUAGUAACAUUGGA	UCCAAUGUUACUAGCAAAG	Chmp	[232-250]
					103	CGUUAUCUACUUCGUGGUA	UACCACGAAGUAGAUAACG	Chmp	[106-124]
104	UACUGAGUUUGCUUAUGGA	UCCAUAAGCAAACUCAGUA	Chmp	[1513-1531]
					105	UCUUCACCAUGGACAUCUA	UAGAUGUCCAUGGUGAAGA	大鼠，Ms	[1221-1239]
106	GAGGCCUGAUGCUAUCAGU	ACUGAUAGCAUCAGGCCUC	Chmp	[1146-1164]
					107	GUGGUUUAUAAUCCUUGAA	UUCAAGGAUUAUAAACCAC		[2336-2354]
108	CAGGAAUGAUCAGCCGCAU	AUGCGGCUGAUCAUUCCUG	Chmp	[1002-1020]
					109	GCAACUGUCCCACGAUUAU	AUAAUCGUGGGACAGUUGC	Chmp	[1554-1572]
110	GUCCCUUCAGAAUGUGAGA	UCUCACAUUCUGAAGGGAC	Chmp	[1049-1067]
					111	CCUUGCAGACGGUGAUCAU	AUGAUCACCGUCUGCAAGG	Chmp	[624-642]
112	UGUUUAUCCUGGUGCUGAU	AUCAGCACCAGGAUAAACA	Chmp	[1293-1311]
					113	CCAUCCUUACCUUGUGGUA	UACCACAAGGUAAGGAUGG	Chmp	[861-879]
114	CAAAGAGGAGCGUAUUGAC	GUCAAUACGCUCCUCUUUG	Chmp	[1708-1726]
					115	AGGCCUGAAUCUGUAUUUA	UAAAUACAGAUUCAGGCCU	Chmp	[529-547]
116	GACAGUGUUGAACGUCAAU	AUUGACGUUCAACACUGUC		[1936-1954]
					117	ACCUUUUGCUGUAGAUUUA	UAAAUCUACAGCAAAAGGU		[2011-2029]
118	CCUUCAGAAUGUGAGAAAU	AUUUCUCACAUUCUGAAGG	Chmp	[1052-1070]
					119	CCGACUCCUUCCACAUCUU	AAGAUGUGGAAGGAGUCGG	Chmp	[789-807]
120	GAGAAAUAUUGCGGUACCA	UGGUACCGCAAUAUUUCUC	Chmp	[1064-1082]
					121	ACAGCAAAGAGGAGCGUAU	AUACGCUCCUCUUUGCUGU	Chmp	[1704-1722]
122	GGUACUGGUGCACAGAUCA	UGAUCUGUGCACCAGUACC	Chmp	[876-894]
					123	AGAUGACUGAGGAAGAGGA	UCCUCUUCCUCAGUCAUCU	Chmp	[1866-1884]
124	GAAUAUUGUUUUAGAAACU	AGUUUCUAAAACAAUAUUC	Chmp	[2352-2370]

125	AGUCCUACCUUUUGCUGUA	UACAGCAAAAGGUAGGACU	Chmp	[2005-2023]
					126	AGAUGACGGACACCUCUGA	UCAGAGGUGUCCGUCAUCU	Chmp	[1902-1920]
127	AUGACGCCUUCAUGGAAAA	UUUUCCAUGAAGGCGUCAU	Chmp	[696-714]
					128	UGAAGAUGAAGAUGACGGA	UCCGUCAUCUUCAUCUUCA	Chmp	[1893-1911]
129	CCUACCUUUUGCUGUAGAU	AUCUACAGCAAAAGGUAGG	Chmp	[2008-2026]
					130	ACCAUUAGUUUGCUGUUAA	UUAACAGCAAACUAAUGGU	Chmp	[2158-2176]
131	AGCUGGAAGAAAACCAUUA	UAAUGGUUUUCUUCCAGCU	Chmp	[2146-2164]
					132	CUGAGAAGAAAAAAGGAAU	AUUCCUUUUUUCUUCUCAG	Chmp	[1794-1812]
133	CUCAGUCACAUCCAGAAAA	UUUUCUGGAUGUGACUGAG		[2242-2260]
					134	UGUCCCUGCUGCUCUACAU	AUGUAGAGCAGCAGGGACA	Chmp	[453-471]
135	GGUGUUGAAGGGAAAUCAG	CUGAUUUCCCUUCAACACC	Chmp	[2073-2091]
					136	CAUUCGCAAUGCAGCCGAU	AUCGGCUGCAUUGCGAAUG	Chmp	[76-94]
137	CACCAAUCGUGGGACUGUU	AACAGUCCCACGAUUGGUG		[157-175]
					138	UGGGCUAUGUUUUCCACCA	UGGUGGAAAACAUAGCCCA	Chmp	[143-161]
139	CAAGAAGGCCCUAAGGAGA	UCUCCUUAGGGCCUUCUUG	Chmp	[1751-1769]
					140	CCCUGCUGCUCUACAUUUU	AAAAUGUAGAGCAGCAGGG	Chmp	[456-474]
141	AAGAAAAAAGGAAUCUUCA	UGAAGAUUCCUUUUUUCUU	Chmp	[1799-1817]
					142	CUUGCUAUUUUCUGGAAGA	UCUUCCAGAAAAUAGCAAG	Chmp	[1427-1445]
143	UCACGAAGUGGGAGGCUAU	AUAGCCUCCCACUUCGUGA	Chmp	[679-697]
					144	UCCUGAGAAGAAAAAAGGA	UCCUUUUUUCUUCUCAGGA	Chmp	[1792-1810]
145	UGUCAGUGUGGUUUAUAAU	AUUAUAAACCACACUGACA		[2329-2347]
					146	CCCUUCAGAAUGUGAGAAA	UUUCUCACAUUCUGAAGGG	Chmp	[1051-1069]
147	UCAUGGAAAAGUACAUGAA	UUCAUGUACUUUUCCAUGA	Chmp	[705-723]
					148	UAUUGACCUGGAUGCGGAA	UUCCGCAUCCAGGUCAAUA	Chmp	[1720-1738]
149	AAGUUCCUGAGAAGAAAAA	UUUUUCUUCUCAGGAACUU	Chmp	[1788-1806]
					150	GGGACUGAUCCUAGGACUU	AAGUCCUAGGAUCAGUCCC		[1471-1489]
151	AGGCUAGCUGGAAGAAAAC	GUUUUCUUCCAGCUAGCCU	Chmp	[2141-2159]

152	CUAAGGAGACCAUUGAAAU	AUUUCAAUGGUCUCCUUAG		[1761-1779]
					153	AGAAUAUGUCUCACGUGAA	UUCACGUGAGACAUAUUCU	Chmp	[924-942]
154	CAGCCGAUAUCUCCAUCAU	AUGAUGGAGAUAUCGGCUG	Chmp	[87-105]
					155	UUGGAGGCUUUGAAUGGAA	UUCCAUUCAAAGCCUCCAA	Chmp	[303-321]
156	GGUUGUUUAUCCUGGUGCU	AGCACCAGGAUAAACAACC	Chmp	[1290-1308]
					157	UCUACUUCGUGGUAGUGAU	AUCACUACCACGAAGUAGA	Chmp	[111-129]
158	CCUUAGUGGUGGAGCUCAU	AUGAGCUCCACCACUAAGG	Chmp	[1113-1131]
					159	UGACUGAGGAAGAGGAGAA	UUCUCCUCUUCCUCAGUCA	Chmp	[1869-1887]
160	ACCCAAGAUGACUGAGGAA	UUCCUCAGUCAUCUUGGGU	Chmp	[1861-1879]
					161	CUGGGUUUGCUUUUCACGA	UCGUGAAAAGCAAACCCAG	Chmp	[666-684]
162	GCUGGAAGAAAACCAUUAG	CUAAUGGUUUUCUUCCAGC	Chmp	[2147-2165]
					163	CUUUGUGGAGGACAGUGUU	AACACUGUCCUCCACAAAG		[1926-1944]
164	ACUGAGUUUGCUUAUGGAA	UUCCAUAAGCAAACUCAGU	Chmp	[1514-1532]
					165	UGGAGGCUUUGAAUGGAAU	AUUCCAUUCAAAGCCUCCA	Chmp	[304-322]
166	AGAGAGCAUCUGAGAAAGA	UCUUUCUCAGAUGCUCUCU	Chmp	[1254-1272]
					167	AGAAAUAUUGCGGUACCAA	UUGGUACCGCAAUAUUUCU	Chmp	[1065-1083]
168	UGCUCUACAUUUUCACCAA	UUGGUGAAAAUGUAGAGCA	Chmp	[462-480]
					169	GACUGAUCCUAGGACUUCU	AGAAGUCCUAGGAUCAGUC		[1473-1491]
170	GCUGUUAAUUUAUGCAUUU	AAAUGCAUAAAUUAACAGC	Chmp	[2169-2187]
					171	GUUUAUAAUCCUUGAAUAU	AUAUUCAAGGAUUAUAAAC		[2339-2357]
172	UCUGGAAGAGAGUCAAUGA	UCAUUGACUCUCUUCCAGA	Chmp	[1437-1455]
					173	UGCCCAGGUGGAUAAAUGU	ACAUUUAUCCACCUGGGCA		[2106-2124]
174	UCACCAAGAUCUCGGCAGA	UCUGCCGAGAUCUUGGUGA	Chmp	[474-492]
					175	AGACGGUGAUCAUGCUGGU	ACCAGCAUGAUCACCGUCU	Chmp	[630-648]
176	CUGUGGGCUAUGUUUUCCA	UGGAAAACAUAGCCCACAG	Chmp	[140-158]
					177	ACCAACAUCGCCUAUCCAA	UUGGAUAGGCGAUGUUGGU	Chmp	[1094-1112]
178	GGCCUGAUGCUAUCAGUCA	UGACUGAUAGCAUCAGGCC	Chmp	[1148-1166]

179	UGCUUUUCACGAAGUGGGA	UCCCACUUCGUGAAAAGCA	Chmp	[673-691]
					180	ACUCAGUCACAUCCAGAAA	UUUCUGGAUGUGACUGAGU		[2241-2259]
181	GAAGGUUGUUUAUCCUGGU	ACCAGGAUAAACAACCUUC	Chmp	[1287-1305]
					182	CUAGGACUUCUGAUUGGGA	UCCCAAUCAGAAGUCCUAG		[1481-1499]
183	GCUAUGACGCCUUCAUGGA	UCCAUGAAGGCGUCAUAGC	Chmp	[693-711]
					184	CCUCCUCACCAAACCCAUU	AAUGGGUUUGGUGAGGAGG	Chmp	[1645-1663]
185	CCUUCCACAUCUUCCGAGA	UCUCGGAAGAUGUGGAAGG	Chmp	[795-813]
					186	GAGAAGCCUUUGUGGAGGA	UCCUCCACAAAGGCUUCUC	Ms，Chmp	[1919-1937]
187	GACUCUUACUCACCUUCCU	AGGAAGGUGAGUAAGAGUC	Chmp	[2039-2057]
					188	CCUGGGUUCAUCUUUGGGA	UCCCAAAGAUGAACCCAGG	Chmp	[839-857]
189	GUGGGCAACUCUUCGAUUA	UAAUCGAAGAGUUGCCCAC	Chmp	[1356-1374]
					190	CUGCUGCUCUACAUUUUCA	UGAAAAUGUAGAGCAGCAG	Chmp	[458-476]
191	UGGUGUUGAAGGGAAAUCA	UGAUUUCCCUUCAACACCA	Chmp	[2072-2090]
					192	GCAAAGAGGAGCGUAUUGA	UCAAUACGCUCCUCUUUGC	Chmp	[1707-1725]
193	AGAUCUCGGCAGACAUCUU	AAGAUGUCUGCCGAGAUCU	Chmp	[480-498]
					194	AGGACAGUGUUGAACGUCA	UGACGUUCAACACUGUCCU		[1934-1952]
195	CCACUCAGUCACAUCCAGA	UCUGGAUGUGACUGAGUGG		[2239-2257]
					196	GUAGAUUCCGGGUGUCAGU	ACUGACACCCGGAAUCUAC	Chmp	[2317-2335]
197	GAAAUAUUGCGGUACCAAG	CUUGGUACCGCAAUAUUUC	Chmp	[1066-1084]
					198	AGGAGAGCCUAUGACCUAU	AUAGGUCAUAGGCUCUCCU	Chmp	[1817-1835]
199	UCGAUUACAUCCAGUCCAU	AUGGACUGGAUGUAAUCGA	Chmp	[1368-1386]
					200	UUCUGUCCCUGCUGCUCUA	UAGAGCAGCAGGGACAGAA	Chmp	[450-468]
201	UCAUCUUUGGGAUGUCCAU	AUGGACAUCCCAAAGAUGA	Chmp	[846-864]
					202	GCUGUACCAACAUCGCCUA	UAGGCGAUGUUGGUACAGC	大鼠，Ms，Chmp	[1089-1107]
203	GAGAGCCUAUGACCUAUUU	AAAUAGGUCAUAGGCUCUC	Chmp	[1819-1837]
					204	AUCCUUGAAUAUUGUUUUA	UAAAACAAUAUUCAAGGAU	Chmp	[2346-2364]
205	ACCCAUUCCGGAUGUGCAU	AUGCACAUCCGGAAUGGGU	Chmp	[1657-1675]

206	CCCUCUUUGCUAGUAACAU	AUGUUACUAGCAAAGAGGG	Chmp	[228-246]
					207	UCAUCACCAUCGUGGUCAU	AUGACCACGAUGGUGAUGA	Chmp	[1623-1641]
208	CGCCUUCAUGGAAAAGUAC	GUACUUUUCCAUGAAGGCG	Chmp	[700-718]
					209	GGUGCACAGAUCAGGUCAU	AUGACCUGAUCUGUGCACC	Chmp	[882-900]
210	GGACUGUGGGCUAUGUUUU	AAAACAUAGCCCACAGUCC	Chmp	[137-155]
					211	GUAUUGACCUGGAUGCGGA	UCCGCAUCCAGGUCAAUAC	Chmp	[1719-1737]
212	GCCUUCAUGGAAAAGUACA	UGUACUUUUCCAUGAAGGC	Chmp	[701-719]
					213	GCAACACCACCUUUCAGGA	UCCUGAAAGGUGGUGUUGC	Chmp	[750-768]
214	AACCCAUUCCGGAUGUGCA	UGCACAUCCGGAAUGGGUU	Chmp	[1656-1674]
					215	GAUUGAUGUCUGACGUGAG	CUCACGUCAGACAUCAAUC		[2288-2306]
216	GCUAGCUGGAAGAAAACCA	UGGUUUUCUUCCAGCUAGC	Chmp	[2143-2161]
					217	UGCUUGCUAUUUUCUGGAA	UUCCAGAAAAUAGCAAGCA	Chmp	[1425-1443]
218	UGACCUAUUUUGUGGGCUA	UAGCCCACAAAAUAGGUCA		[1828-1846]
					219	CCAUUUCUUUCAUCACCAU	AUGGUGAUGAAAGAAAUGG	Chmp	[1614-1632]
220	CUUCAGAAUGUGAGAAAUA	UAUUUCUCACAUUCUGAAG	Chmp	[1053-1071]
					221	GGAUGUGCAUCUCUACCGU	ACGGUAGAGAUGCACAUCC	Chmp	[1666-1684]
222	GAAGAUGACGGACACCUCU	AGAGGUGUCCGUCAUCUUC	Chmp	[1900-1918]
					223	UGAUCCUAGGACUUCUGAU	AUCAGAAGUCCUAGGAUCA		[1476-1494]
224	AGGCAGACUAAGAAUCAGA	UCUGAUUCUUAGUCUGCCU		[2261-2279]
					225	GCGGUGAUUUACACGGACA	UGUCCGUGUAAAUCACCGC	Chmp	[605-623]
226	CUGGAAGAAAACCAUUAGU	ACUAAUGGUUUUCUUCCAG	Chmp	[2148-2166]
					227	UCCGCAAGAGAGCAUCUGA	UCAGAUGCUCUCUUGCGGA	Chmp	[1248-1266]
228	AAUUAUAGGCUAGCUGGAA	UUCCAGCUAGCCUAUAAUU	Chmp	[2135-2153]
					229	CCAAGAAUAUGUCUCACGU	ACGUGAGACAUAUUCUUGG	Chmp	[921-939]
230	UAAUUAUAGGCUAGCUGGA	UCCAGCUAGCCUAUAAUUA	Chmp	[2134-2152]
					231	GAAUCUUCAGGAGAGCCUA	UAGGCUCUCCUGAAGAUUC	Chmp	[1809-1827]
232	CACGUAUGAUUACUGAGUU	AACUCAGUAAUCAUACGUG	Chmp	[1503-1521]

233	CUUUAAUCCUGACUGGGUU	AACCCAGUCAGGAUUAAAG	Chmp	[654-672]
					234	UACCAACAUCGCCUAUCCA	UGGAUAGGCGAUGUUGGUA	Chmp	[1093-1111]
235	CAUCUGAGAAAGAGCUCAU	AUGAGCUCUUUCUCAGAUG	Chmp	[1260-1278]
					236	GAUCCUAGGACUUCUGAUU	AAUCAGAAGUCCUAGGAUC		[1477-1495]
237	CAAGAUGACUGAGGAAGAG	CUCUUCCUCAGUCAUCUUG	Chmp	[1864-1882]
					238	UCAGAAUGUGAGAAAUAUU	AAUAUUUCUCACAUUCUGA	Chmp	[1055-1073]
239	CUGCUUGCUAUUUUCUGGA	UCCAGAAAAUAGCAAGCAG	Chmp	[1424-1442]
					240	AUAGGCUAGCUGGAAGAAA	UUUCUUCCAGCUAGCCUAU	Chmp	[2139-2157]
241	CCGAUAUCUCCAUCAUCGU	ACGAUGAUGGAGAUAUCGG	Chmp	[90-108]
					242	GACUGGGUUUGCUUUUCAC	GUGAAAAGCAAACCCAGUC	Chmp	[664-682]
243	CCUUUAGUCUCGUCCUGUG	CACAGGACGAGACUAAAGG	Chmp	[2055-2073]
					244	UGAGAAAGAGCUCAUGAUU	AAUCAUGAGCUCUUUCUCA	Chmp	[1264-1282]
245	CAGCAACUGUCCCACGAUU	AAUCGUGGGACAGUUGCUG	Chmp	[1552-1570]
					246	AGAUGAAGAUGACGGACAC	GUGUCCGUCAUCUUCAUCU	Chmp	[1896-1914]
247	CAUCCAAGAAGGCCCUAAG	CUUAGGGCCUUCUUGGAUG	Chmp	[1747-1765]
					248	UAGUUUGCUGUUAAUUUAU	AUAAAUUAACAGCAAACUA	Chmp	[2163-2181]
249	UCCAGAAAAAGGCAGACUA	UAGUCUGCCUUUUUCUGGA		[2252-2270]
					250	GGAGAGCCUAUGACCUAUU	AAUAGGUCAUAGGCUCUCC	Chmp	[1818-1836]
251	UGCUGUUAAUUUAUGCAUU	AAUGCAUAAAUUAACAGCA	Chmp	[2168-2186]
					252	CAACACCACCUUUCAGGAA	UUCCUGAAAGGUGGUGUUG	Chmp	[751-769]
253	UAUGACGCCUUCAUGGAAA	UUUCCAUGAAGGCGUCAUA	Chmp	[695-713]
					254	CGGUGAUUUACACGGACAC	GUGUCCGUGUAAAUCACCG	Chmp	[606-624]
255	CCAACAUCGCCUAUCCAAC	GUUGGAUAGGCGAUGUUGG	Chmp	[1095-1113]
					256	UCGCCUAUCCAACCUUAGU	ACUAAGGUUGGAUAGGCGA	Chmp	[1101-1119]
257	UGACUGGGUUUGCUUUUCA	UGAAAAGCAAACCCAGUCA	Chmp	[663-681]
					258	UGUUAAUUUAUGCAUUUGA	UCAAAUGCAUAAAUUAACA	Chmp	[2171-2189]
259	AAGAGGAGAACAUCCAAGA	UCUUGGAUGUUCUCCUCUU	Chmp	[1737-1755]

260	GUGGUACUGGUGCACAGAU	AUCUGUGCACCAGUACCAC	Chmp	[874-892]
					261	CGCAAUGCAGCCGAUAUCU	AGAUAUCGGCUGCAUUGCG	Chmp	[80-98]
262	AAGGGAGUCCACUCAGUCA	UGACUGAGUGGACUCCCUU		[2231-2249]
					263	GGGUUUGCUUUUCACGAAG	CUUCGUGAAAAGCAAACCC	Chmp	[668-686]
264	CAGAAAAAGGCAGACUAAG	CUUAGUCUGCCUUUUUCUG		[2254-2272]
					265	UGCCCAUGUUCAUCAUGGU	ACCAUGAUGAACAUGGGCA		[978-996]
266	UUGCCUGAGUCCUACCUUU	AAAGGUAGGACUCAGGCAA		[1998-2016]
					267	UUCCGGAUGUGCAUCUCUA	UAGAGAUGCACAUCCGGAA	Chmp	[1662-1680]
268	CCCUGGUUUUGGUGGUUGU	ACAACCACCAAAACCAGGG	Chmp	[324-342]
					269	AUAUCUCCAUCAUCGUUAU	AUAACGAUGAUGGAGAUAU	Chmp	[93-111]
270	ACGAAGUGGGAGGCUAUGA	UCAUAGCCUCCCACUUCGU	Chmp	[681-699]
					271	UUGCCGGAAGGUUGUUUAU	AUAAACAACCUUCCGGCAA	Chmp	[1281-1299]
272	UUUGCUAGUAACAUUGGAA	UUCCAAUGUUACUAGCAAA	Chmp	[233-251]
					273	AUAUUUUGCCUGAGUCCUA	UAGGACUCAGGCAAAAUAU		[1993-2011]
274	GGUGUCAGUGUGGUUUAUA	UAUAAACCACACUGACACC		[2327-2345]
					275	GAUUACAUCCAGUCCAUCA	UGAUGGACUGGAUGUAAUC	Chmp	[1370-1388]
276	CGAUAUCUCCAUCAUCGUU	AACGAUGAUGGAGAUAUCG	Chmp	[91-109]
					277	GAUUACUGAGUUUGCUUAU	AUAAGCAAACUCAGUAAUC	Chmp	[1510-1528]
278	AGCCUAUGACCUAUUUUGU	ACAAAAUAGGUCAUAGGCU	Chmp	[1822-1840]
					279	GUCCCUGCUGCUCUACAUU	AAUGUAGAGCAGCAGGGAC	Chmp	[454-472]
280	CAGAUCAGGUCAUUGUGCA	UGCACAAUGACCUGAUCUG	Chmp	[888-906]
					281	GCUAUUUUCUGGAAGAGAG	CUCUCUUCCAGAAAAUAGC	Chmp	[1430-1448]
282	UCCAGUCCAUCACCAGUUA	UAACUGGUGAUGGACUGGA	大鼠，Chmp	[1377-1395]
					283	GUUACUUGGGACCACCCAU	AUGGGUGGUCCCAAGUAAC	Chmp	[1392-1410]
284	CCAGGUCUACCUUUCCCUU	AAGGGAAAGGUAGACCUGG	Chmp	[433-451]
					285	UUCCAACCAUAGUGUCUGA	UCAGACACUAUGGUUGGAA	Chmp	[729-747]
286	AGGAGCGUAUUGACCUGGA	UCCAGGUCAAUACGCUCCU	Chmp	[1713-1731]

287	GCAAUCACUGCCCUUUACA	UGUAAAGGGCAGUGAUUGC	Chmp	[566-584]
					288	AUUGGGAUUUCACGUAUGA	UCAUACGUGAAAUCCCAAU	Chmp	[1493-1511]
289	CUAUUUUCUGGAAGAGAGU	ACUCUCUUCCAGAAAAUAG	Chmp	[1431-1449]
					290	GAGAGCAUCUGAGAAAGAG	CUCUUUCUCAGAUGCUCUC	Chmp	[1255-1273]
291	UGUCGUCCCUUCAGAAUGU	ACAUUCUGAAGGGACGACA	Chmp	[1045-1063]
					292	UGUGGUGUUGAAGGGAAAU	AUUUCCCUUCAACACCACA	Chmp	[2070-2088]
293	ACUUCUGAUUGGGAUUUCA	UGAAAUCCCAAUCAGAAGU		[1486-1504]
					294	GAAUGAUCAGCCGCAUUCU	AGAAUGCGGCUGAUCAUUC	Chmp	[1005-1023]
295	UGCAGACGGUGAUCAUGCU	AGCAUGAUCACCGUCUGCA	Chmp	[627-645]
					296	UGAGUCUGUCUCAGGUAGA	UCUACCUGAGACAGACUCA	Chmp	[2303-2321]
297	CACAAAGUGGGCAACUCUU	AAGAGUUGCCCACUUUGUG	Chmp	[1350-1368]
					298	GCACAAAGUGGGCAACUCU	AGAGUUGCCCACUUUGUGC	Chmp	[1349-1367]
299	GGAGUCCACUCAGUCACAU	AUGUGACUGAGUGGACUCC		[2234-2252]
					300	UGAUUUACACGGACACCUU	AAGGUGUCCGUGUAAAUCA	Chmp	[609-627]
301	CAGGAAAAAUGCUACACUC	GAGUGUAGCAUUUUUCCUG	Chmp	[764-782]
					302	CGUCCCUUCAGAAUGUGAG	CUCACAUUCUGAAGGGACG	Chmp	[1048-1066]
303	UCUUCAGGAGAGCCUAUGA	UCAUAGGCUCUCCUGAAGA	Chmp	[1812-1830]
					304	CAGUGUUGAACGUCAAUGG	CCAUUGACGUUCAACACUG		[1938-1956]
305	CUGAUCCUAGGACUUCUGA	UCAGAAGUCCUAGGAUCAG		[1475-1493]
					306	GGCCUGAAUCUGUAUUUAG	CUAAAUACAGAUUCAGGCC	Chmp	[530-548]
307	UGUGAGAAAUAUUGCGGUA	UACCGCAAUAUUUCUCACA	Chmp	[1061-1079]
					308	ACACCUUGCAGACGGUGAU	AUCACCGUCUGCAAGGUGU	Chmp	[621-639]
309	UUUGGGAUGUCCAUCCUUA	UAAGGAUGGACAUCCCAAA	Chmp	[851-869]
					310	UUGAGACCCACGAGCUCAU	AUGAGCUCGUGGGUCUCAA	Chmp	[60-78]
311	AUGCGGAAGAGGAGAACAU	AUGUUCUCCUCUUCCGCAU	Chmp	[1731-1749]
					312	CCACCUUUCAGGAAAAAUG	CAUUUUUCCUGAAAGGUGG	Chmp	[756-774]
313	UGUGGGUAUCUAAAGCUGA	UCAGCUUUAGAUACCCACA		[959-977]

314	CAGUCACAUCCAGAAAAAG	CUUUUUCUGGAUGUGACUG	Chmp	[2244-2262]
					315	CAACCUUAGUGGUGGAGCU	AGCUCCACCACUAAGGUUG	Chmp	[1110-1128]
316	UGGAUGCGGAAGAGGAGAA	UUCUCCUCUUCCGCAUCCA	Chmp	[1728-1746]
					317	AGAAGGGAGUCCACUCAGU	ACUGAGUGGACUCCCUUCU		[2229-2247]
318	UGAUGCCCAUGUUCAUCAU	AUGAUGAACAUGGGCAUCA		[975-993]
					319	GCACAGAUCAGGUCAUUGU	ACAAUGACCUGAUCUGUGC	Chmp	[885-903]
320	AAAGGCAGACUAAGAAUCA	UGAUUCUUAGUCUGCCUUU		[2259-2277]
					321	CAUCACCAGUUACUUGGGA	UCCCAAGUAACUGGUGAUG	Chmp	[1384-1402]
322	GAUGCGGAAGAGGAGAACA	UGUUCUCCUCUUCCGCAUC	Chmp	[1730-1748]
					323	AAGCCUUUGUGGAGGACAG	CUGUCCUCCACAAAGGCUU	Ms，Chmp	[1922-1940]
324	UGGGAUUUCACGUAUGAUU	AAUCAUACGUGAAAUCCCA	Chmp	[1495-1513]
					325	ACCUUGUGGUACUGGUGCA	UGCACCAGUACCACAAGGU	Chmp	[869-887]
326	UUUUCUGGAAGAGAGUCAA	UUGACUCUCUUCCAGAAAA	Chmp	[1434-1452]
					327	UGUGGUACUGGUGCACAGA	UCUGUGCACCAGUACCACA	Chmp	[873-891]
328	GGAAUGCCCUGGUUUUGGU	ACCAAAACCAGGGCAUUCC	Chmp	[318-336]
					329	CAUCCAGUCCAUCACCAGU	ACUGGUGAUGGACUGGAUG	大鼠，Chmp	[1375-1393]
330	CGCCUAUCCAACCUUAGUG	CACUAAGGUUGGAUAGGCG	Chmp	[1102-1120]
					331	GAUGACUGAGGAAGAGGAG	CUCCUCUUCCUCAGUCAUC	Chmp	[1867-1885]
332	UGAUGCUAUCAGUCAUGCU	AGCAUGACUGAUAGCAUCA	Chmp	[1152-1170]
					333	GGCAAUCACUGCCCUUUAC	GUAAAGGGCAGUGAUUGCC	Chmp	[565-583]
334	ACGUGAGUCUGUCUCAGGU	ACCUGAGACAGACUCACGU		[2300-2318]
					335	GAGCUCAUUCGCAAUGCAG	CUGCAUUGCGAAUGAGCUC	Chmp	[71-89]
336	AUCUAAAGCUGAUGCCCAU	AUGGGCAUCAGCUUUAGAU		[966-984]
					337	GGGUGCACUACUUGUACUU	AAGUACAAGUAGUGCACCC	Chmp	[1578-1596]
338	UCUACAUUUUCACCAAGAU	AUCUUGGUGAAAAUGUAGA	Chmp	[465-483]
					339	ACGUAUGAUUACUGAGUUU	AAACUCAGUAAUCAUACGU	Chmp	[1504-1522]
340	AGAGCCUAUGACCUAUUUU	AAAAUAGGUCAUAGGCUCU	Chmp	[1820-1838]

341	CUGACGUGAGUCUGUCUCA	UGAGACAGACUCACGUCAG		[2297-2315]
					342	UGACCUCCAUCUUCAACAG	CUGUUGAAGAUGGAGGUCA	大鼠，Ms，Chmp	[1191-1209]
343	CUUAGGCCUGAAUCUGUAU	AUACAGAUUCAGGCCUAAG	Chmp	[526-544]
					344	GCUGUCUUCCUGCUUGCUA	UAGCAAGCAGGAAGACAGC	Chmp	[1415-1433]
345	AAAAAGGCAGACUAAGAAU	AUUCUUAGUCUGCCUUUUU		[2257-2275]
					346	CACAGAUCAGGUCAUUGUG	CACAAUGACCUGAUCUGUG	Chmp	[886-904]
347	GAAUAUGUCUCACGUGAAG	CUUCACGUGAGACAUAUUC	Chmp	[925-943]
					348	GGAGGCUUUGAAUGGAAUG	CAUUCCAUUCAAAGCCUCC	Chmp	[305-323]
349	UAUAAUCCUUGAAUAUUGU	ACAAUAUUCAAGGAUUAUA		[2342-2360]
					350	AUUGGAGGCUUUGAAUGGA	UCCAUUCAAAGCCUCCAAU	Chmp	[302-320]
351	AGAGCUCAUGAUUGCCGGA	UCCGGCAAUCAUGAGCUCU	Chmp	[1270-1288]
					352	AAUGCAGCCGAUAUCUCCA	UGGAGAUAUCGGCUGCAUU	Chmp	[83-101]
353	CGGAUCCAGGUCUACCUUU	AAAGGUAGACCUGGAUCCG	Chmp	[428-446]
					354	GUUCCUGAGAAGAAAAAAG	CUUUUUUCUUCUCAGGAAC	Chmp	[1790-1808]
355	CAAGAUCUCGGCAGACAUC	GAUGUCUGCCGAGAUCUUG	Chmp	[478-496]
					356	CUUCCUGCUUGCUAUUUUC	GAAAAUAGCAAGCAGGAAG	Chmp	[1420-1438]
357	UGCUAUUUUCUGGAAGAGA	UCUCUUCCAGAAAAUAGCA	Chmp	[1429-1447]
					358	GCCUUAGGCCUGAAUCUGU	ACAGAUUCAGGCCUAAGGC	Chmp	[524-542]
359	AGCUCAUGCCCAAUGGACU	AGUCCAUUGGGCAUGAGCU	Chmp	[1125-1143]
					360	UCUGAGAAGCCUUUGUGGA	UCCACAAAGGCUUCUCAGA	Ms，Chmp	[1916-1934]
361	CUCCCUCUUUGCUAGUAAC	GUUACUAGCAAAGAGGGAG	Chmp	[226-244]
					362	AGGCUAUGACGCCUUCAUG	CAUGAAGGCGUCAUAGCCU	Chmp	[691-709]
363	GUCAGCACAAAGUGGGCAA	UUGCCCACUUUGUGCUGAC	Chmp	[1345-1363]
					364	AGUCCAUCACCAGUUACUU	AAGUAACUGGUGAUGGACU	Chmp	[1380-1398]
365	UGGUUUAUAAUCCUUGAAU	AUUCAAGGAUUAUAAACCA		[2337-2355]
					366	UUAUCUACUUCGUGGUAGU	ACUACCACGAAGUAGAUAA	Chmp	[108-126]
367	UUUUGCCCAGGUGGAUAAA	UUUAUCCACCUGGGCAAAA		[2103-2121]

368	CUGGAAGAGAGUCAAUGAG	CUCAUUGACUCUCUUCCAG	Chmp	[1438-1456]
					369	UAGCUGGAAGAAAACCAUU	AAUGGUUUUCUUCCAGCUA	Chmp	[2145-2163]
370	AACUCUUCGAUUACAUCCA	UGGAUGUAAUCGAAGAGUU	Chmp	[1362-1380]
					371	AGGAGAACAUCCAAGAAGG	CCUUCUUGGAUGUUCUCCU	Chmp	[1740-1758]
372	UAGGACUUCUGAUUGGGAU	AUCCCAAUCAGAAGUCCUA		[1482-1500]
					373	CUUCCUUUAGUCUCGUCCU	AGGACGAGACUAAAGGAAG	Chmp	[2052-2070]
374	AUUUUGCCCAGGUGGAUAA	UUAUCCACCUGGGCAAAAU		[2102-2120]
					375	GAGCCUAUGACCUAUUUUG	CAAAAUAGGUCAUAGGCUC	Chmp	[1821-1839]
376	CUUUCAUCACCAUCGUGGU	ACCACGAUGGUGAUGAAAG	Chmp	[1620-1638]
					377	GUCCACUCAGUCACAUCCA	UGGAUGUGACUGAGUGGAC		[2237-2255]
378	CCUGCUUGCUAUUUUCUGG	CCAGAAAAUAGCAAGCAGG	Chmp	[1423-1441]
					379	CUGAUUGGGAUUUCACGUA	UACGUGAAAUCCCAAUCAG	Chmp	[1490-1508]
380	UCACAUCCAGAAAAAGGCA	UGCCUUUUUCUGGAUGUGA	Chmp	[2247-2265]
					381	GGUCUUUAAUCCUGACUGG	CCAGUCAGGAUUAAAGACC	Chmp	[651-669]
382	AAGAAUAUGUCUCACGUGA	UCACGUGAGACAUAUUCUU	Chmp	[923-941]
					383	GACUGUGGGCUAUGUUUUC	GAAAACAUAGCCCACAGUC	Chmp	[138-156]
384	CCAUUGUGCAGUCAGCACA	UGUGCUGACUGCACAAUGG		[1335-1353]
					385	GCUGGACUCUUACUCACCU	AGGUGAGUAAGAGUCCAGC	Chmp	[2035-2053]
386	AACACCACCUUUCAGGAAA	UUUCCUGAAAGGUGGUGUU	Chmp	[752-770]
					387	GCAUCUGAGAAAGAGCUCA	UGAGCUCUUUCUCAGAUGC	Chmp	[1259-1277]
388	CCAUCUGUACCUACUGGAG	CUCCAGUAGGUACAGAUGG	Chmp	[2206-2224]
					389	CUGAGAAGCCUUUGUGGAG	CUCCACAAAGGCUUCUCAG	Ms，Chmp	[1917-1935]
390	GUGUAAUUAUAGGCUAGCU	AGCUAGCCUAUAAUUACAC	Chmp	[2131-2149]
					391	CAACCAUAGUGUCUGAUGG	CCAUCAGACACUAUGGUUG	Chmp	[732-750]
392	GCCUGAAUCUGUAUUUAGC	GCUAAAUACAGAUUCAGGC	Chmp	[531-549]
					393	GCCUGAGUCCUACCUUUUG	CAAAAGGUAGGACUCAGGC		[2000-2018]
394	CAGUCCAUCACCAGUUACU	AGUAACUGGUGAUGGACUG	Chmp	[1379-1397]

395	CAAUCACUGCCCUUUACAC	GUGUAAAGGGCAGUGAUUG	Chmp	[567-585]
					396	UGUGCAGUCAGCACAAAGU	ACUUUGUGCUGACUGCACA	Chmp	[1339-1357]
397	GCAGACUAAGAAUCAGAAG	CUUCUGAUUCUUAGUCUGC		[2263-2281]
					398	GCCGGAAGGUUGUUUAUCC	GGAUAAACAACCUUCCGGC	Chmp	[1283-1301]
399	UAUAGGCUAGCUGGAAGAA	UUCUUCCAGCUAGCCUAUA	Chmp	[2138-2156]
					400	AGUUACUUGGGACCACCCA	UGGGUGGUCCCAAGUAACU	Chmp	[1391-1409]
401	CUGACCUCCAUCUUCAACA	UGUUGAAGAUGGAGGUCAG	Chmp	[1190-1208]
					402	AAACCAUUAGUUUGCUGUU	AACAGCAAACUAAUGGUUU	Chmp	[2156-2174]
403	CUCUACAUUUUCACCAAGA	UCUUGGUGAAAAUGUAGAG	Chmp	[464-482]
					404	AACCAUUAGUUUGCUGUUA	UAACAGCAAACUAAUGGUU	Chmp	[2157-2175]
405	GGUUUGCUUUUCACGAAGU	ACUUCGUGAAAAGCAAACC	Chmp	[669-687]
					406	CAUGCAUAUUUUGCCUGAG	CUCAGGCAAAAUAUGCAUG		[1988-2006]
407	UUCAGAAUGUGAGAAAUAU	AUAUUUCUCACAUUCUGAA	Chmp	[1054-1072]
					408	UGGUUUUGGUGGUUGUGCU	AGCACAACCACCAAAACCA	Ms，Chmp	[327-345]
409	CAUUAGUUUGCUGUUAAUU	AAUUAACAGCAAACUAAUG	Chmp	[2160-2178]
					410	UCUUACUCACCUUCCUUUA	UAAAGGAAGGUGAGUAAGA	Chmp	[2042-2060]
411	AUGGAAAAGUACAUGAAAG	CUUUCAUGUACUUUUCCAU	Chmp	[707-725]
					412	UGAUUGGGAUUUCACGUAU	AUACGUGAAAUCCCAAUCA	Chmp	[1491-1509]
413	GAAGAAAACCAUUAGUUUG	CAAACUAAUGGUUUUCUUC	Chmp	[2151-2169]
					414	AGAAAAAAGGAAUCUUCAG	CUGAAGAUUCCUUUUUUCU	Chmp	[1800-1818]
415	CCUUUCAGGAAAAAUGCUA	UAGCAUUUUUCCUGAAAGG	Chmp	[759-777]
					416	UGUGAUUGAUGUCUGACGU	ACGUCAGACAUCAAUCACA		[2285-2303]
417	UGAUUGAUGUCUGACGUGA	UCACGUCAGACAUCAAUCA		[2287-2305]
					418	AGAGGAGCGUAUUGACCUG	CAGGUCAAUACGCUCCUCU	Chmp	[1711-1729]
419	UUGGGAUGUCCAUCCUUAC	GUAAGGAUGGACAUCCCAA	Chmp	[852-870]
					420	UCCCUGACCUCCAUCUUCA	UGAAGAUGGAGGUCAGGGA	Chmp	[1187-1205]
421	AGUGUGGUUUAUAAUCCUU	AAGGAUUAUAAACCACACU		[2333-2351]

422	AAAAAAGGAAUCUUCAGGA	UCCUGAAGAUUCCUUUUUU	Chmp	[1802-1820]
					423	UUAUAGGCUAGCUGGAAGA	UCUUCCAGCUAGCCUAUAA	Chmp	[2137-2155]
424	UGAAUAUUGUUUUAGAAAC	GUUUCUAAAACAAUAUUCA	Chmp	[2351-2369]
					425	CUGGACUCUUACUCACCUU	AAGGUGAGUAAGAGUCCAG	Chmp	[2036-2054]
426	GGAGAACAUCCAAGAAGGC	GCCUUCUUGGAUGUUCUCC	Chmp	[1741-1759]
					427	AAUGGAAUGCCCUGGUUUU	AAAACCAGGGCAUUCCAUU	Chmp	[315-333]
428	CCUUUGUGGAGGACAGUGU	ACACUGUCCUCCACAAAGG		[1925-1943]
					429	GUGCAUCUCUACCGUCUGU	ACAGACGGUAGAGAUGCAC	Chmp	[1670-1688]
430	UGAUUACUGAGUUUGCUUA	UAAGCAAACUCAGUAAUCA	Chmp	[1509-1527]
					431	GUGCACAGAUCAGGUCAUU	AAUGACCUGAUCUGUGCAC	Chmp	[883-901]
432	AGGUAGAUUCCGGGUGUCA	UGACACCCGGAAUCUACCU	Chmp	[2315-2333]
					433	AUGACGGACACCUCUGAGA	UCUCAGAGGUGUCCGUCAU	Chmp	[1904-1922]
434	GAAUGUGAGAAAUAUUGCG	CGCAAUAUUUCUCACAUUC	Chmp	[1058-1076]
					435	GCCUAUGACCUAUUUUGUG	CACAAAAUAGGUCAUAGGC	Chmp	[1823-1841]
436	GGACUGUUGGAGGCUUCUU	AAGAAGCCUCCAACAGUCC	大鼠	[168-186]
					437	AUUGUGCAGUCAGCACAAA	UUUGUGCUGACUGCACAAU	Chmp	[1337-1355]
438	CUGAGUCCUACCUUUUGCU	AGCAAAAGGUAGGACUCAG		[2002-2020]
					439	GAGCAUCUGAGAAAGAGCU	AGCUCUUUCUCAGAUGCUC	Chmp	[1257-1275]
440	AGCAACUGUCCCACGAUUA	UAAUCGUGGGACAGUUGCU	Chmp	[1553-1571]
					441	CAGUUGUAAAUUUUGCCCA	UGGGCAAAAUUUACAACUG	Chmp	[2093-2111]
442	UUCGCAAUGCAGCCGAUAU	AUAUCGGCUGCAUUGCGAA	Chmp	[78-96]
					443	UGUCUUCCUGCUUGCUAUU	AAUAGCAAGCAGGAAGACA	Chmp	[1417-1435]
444	AGUUGUAAAUUUUGCCCAG	CUGGGCAAAAUUUACAACU	Chmp	[2094-2112]
					445	UUGGGAUUUCACGUAUGAU	AUCAUACGUGAAAUCCCAA	Chmp	[1494-1512]
446	UUUUGCUGUAGAUUUACCA	UGGUAAAUCUACAGCAAAA		[2014-2032]
					447	ACCUAUUUUGUGGGCUAGA	UCUAGCCCACAAAAUAGGU		[1830-1848]
448	CCUGCUGCUCUACAUUUUC	GAAAAUGUAGAGCAGCAGG	Chmp	[457-475]

449	GGGAUGUCCAUCCUUACCU	AGGUAAGGAUGGACAUCCC	Chmp	[854-872]
					450	GCUAUGUUUUCCACCAAUC	GAUUGGUGGAAAACAUAGC	Chmp	[146-164]
451	UCGUCCCUUCAGAAUGUGA	UCACAUUCUGAAGGGACGA	Chmp	[1047-1065]
					452	ACACCUCUGAGAAGCCUUU	AAAGGCUUCUCAGAGGUGU	Chmp	[1911-1929]
453	CUUACCUUGUGGUACUGGU	ACCAGUACCACAAGGUAAG	Chmp	[866-884]
					454	AUUGAUGUCUGACGUGAGU	ACUCACGUCAGACAUCAAU		[2289-2307]
455	GGAUCCAGGUCUACCUUUC	GAAAGGUAGACCUGGAUCC	Chmp	[429-447]
					456	AGGACUUCUGAUUGGGAUU	AAUCCCAAUCAGAAGUCCU		[1483-1501]
457	AUCCAACCUUAGUGGUGGA	UCCACCACUAAGGUUGGAU	Chmp	[1107-1125]
					458	CAUCGUUAUCUACUUCGUG	CACGAAGUAGAUAACGAUG	Chmp	[103-121]
459	GCCUCCCUCUUUGCUAGUA	UACUAGCAAAGAGGGAGGC	Chmp	[224-242]
					460	GGAUUUCACGUAUGAUUAC	GUAAUCAUACGUGAAAUCC	Chmp	[1497-1515]
461	AGCCUUUGUGGAGGACAGU	ACUGUCCUCCACAAAGGCU	Ms，Chmp	[1923-1941]
					462	AGCUCAUGAUUGCCGGAAG	CUUCCGGCAAUCAUGAGCU	Chmp	[1272-1290]
463	AAGAGAGCAUCUGAGAAAG	CUUUCUCAGAUGCUCUCUU	Chmp	[1253-1271]
					464	AAUCCUUGAAUAUUGUUUU	AAAACAAUAUUCAAGGAUU	Chmp	[2345-2363]
465	AGAAGAAAAAAGGAAUCUU	AAGAUUCCUUUUUUCUUCU	Chmp	[1797-1815]
					466	GACACCUCUGAGAAGCCUU	AAGGCUUCUCAGAGGUGUC	Chmp	[1910-1928]
467	GAAGCCUUUGUGGAGGACA	UGUCCUCCACAAAGGCUUC	Ms，Chmp	[1921-1939]
					468	CUCUGAGAAGCCUUUGUGG	CCACAAAGGCUUCUCAGAG	Chmp	[1915-1933]
469	CCUGAUGCUAUCAGUCAUG	CAUGACUGAUAGCAUCAGG	Chmp	[1150-1168]
					470	GAUUGGAGCCUCCCUCUUU	AAAGAGGGAGGCUCCAAUC	Chmp	[217-235]
471	UGUUCAUCAUGGUGAUGCC	GGCAUCACCAUGAUGAACA		[984-1002]
					472	CAUGAUUGCCGGAAGGUUG	CAACCUUCCGGCAAUCAUG	Chmp	[1276-1294]
473	GCAGCCGAUAUCUCCAUCA	UGAUGGAGAUAUCGGCUGC	Chmp	[86-104]
					474	AGUACCUGAGGAAGCGGUU	AACCGCUUCCUCAGGUACU	Chmp	[399-417]
475	AAGCUGAUGCCCAUGUUCA	UGAACAUGGGCAUCAGCUU		[971-989]

476	CUUUGGGAUGUCCAUCCUU	AAGGAUGGACAUCCCAAAG	Chmp	[850-868]
					477	AGACCAUUGAAAUAGAAAC	GUUUCUAUUUCAAUGGUCU		[1767-1785]
478	UGCCUGAGUCCUACCUUUU	AAAAGGUAGGACUCAGGCA		[1999-2017]
					479	AAGUGGGCAACUCUUCGAU	AUCGAAGAGUUGCCCACUU	Chmp	[1354-1372]
480	UCUGAGAAAGAGCUCAUGA	UCAUGAGCUCUUUCUCAGA	Chmp	[1262-1280]
					481	ACAUCCAAGAAGGCCCUAA	UUAGGGCCUUCUUGGAUGU	Chmp	[1746-1764]
482	AUUAGUUUGCUGUUAAUUU	AAAUUAACAGCAAACUAAU	Chmp	[2161-2179]
					483	CUUCCACAUCUUCCGAGAU	AUCUCGGAAGAUGUGGAAG	Chmp	[796-814]
484	CAGAAUGUGAGAAAUAUUG	CAAUAUUUCUCACAUUCUG	Chmp	[1056-1074]
					485	UCUCGUCCUGUGGUGUUGA	UCAACACCACAGGACGAGA	Chmp	[2062-2080]
486	ACCUCUGAGAAGCCUUUGU	ACAAAGGCUUCUCAGAGGU	Chmp	[1913-1931]
					487	UAUUUUGUGGGCUAGAGCA	UGCUCUAGCCCACAAAAUA		[1833-1851]
488	GAACAUCCAAGAAGGCCCU	AGGGCCUUCUUGGAUGUUC	Chmp	[1744-1762]
					489	GCAACUCUUCGAUUACAUC	GAUGUAAUCGAAGAGUUGC	Chmp	[1360-1378]
490	CUAUGUUUUCCACCAAUCG	CGAUUGGUGGAAAACAUAG	Chmp	[147-165]
					491	GAUUGGGAUUUCACGUAUG	CAUACGUGAAAUCCCAAUC	Chmp	[1492-1510]
492	UCACCAUCGUGGUCAUCUC	GAGAUGACCACGAUGGUGA	Chmp	[1626-1644]
					493	CAUUCCAACCAUAGUGUCU	AGACACUAUGGUUGGAAUG	Chmp	[727-745]
494	CACAGAAAAAAUUGCCUGU	ACAGGCAAUUUUUUCUGUG		[1027-1045]
					495	CUACCUUUUGCUGUAGAUU	AAUCUACAGCAAAAGGUAG	Chmp	[2009-2027]
496	AGAAAACCAUUAGUUUGCU	AGCAAACUAAUGGUUUUCU	Chmp	[2153-2171]
					497	ACCAAGAUCUCGGCAGACA	UGUCUGCCGAGAUCUUGGU	Chmp	[476-494]
498	GGAAGAGAGUCAAUGAGCC	GGCUCAUUGACUCUCUUCC	Chmp	[1440-1458]
					499	UAAAUUUUGCCCAGGUGGA	UCCACCUGGGCAAAAUUUA		[2099-2117]
500	AUUGCCGGAAGGUUGUUUA	UAAACAACCUUCCGGCAAU	Chmp	[1280-1298]

表B 32SORD-山梨醇脱氢酶

No.

正义链siRNA

反义链siRNA

其他Sp

人-34147623：131-1204

1	GGUUGAAAAUCAUGCUCAA	UUGAGCAUGAUUUUCAACC		[1158-1176]
					2	GGAAUUUUAUUGUGAAAAA	UUUUUCACAAUAAAAUUCC	Chmp	[303-321]
3	CAACUAGGCUCAUACUCAA	UUGAGUAUGAGCCUAGUUG	Chmp	[2112-2130]
					4	GGUCGAAUUGGGAAUUUUA	UAAAAUUCCCAAUUCGACC	Chmp	[293-311]
5	GAUCCAGGAUAAUUUUUAA	UUAAAAAUUAUCCUGGAUC	Chmp	[1756-1774]
					6	CUUUGAGACUAUUCAUCAA	UUGAUGAAUAGUCUCAAAG	Chmp	[2318-2336]
7	CAAGAAUGAGGAUAUAGUA	UACUAUAUCCUCAUUCUUG	Chmp	[2334-2352]
					8	CCAAGUCUGUGAAUGUAAA	UUUACAUUCACAGACUUGG		[1068-1086]
9	GAUGAUAAAAGGAGAAUAA	UUAUUCUCCUUUUAUCAUC	Chmp	[1717-1735]
					10	GGUGGAGGGUGAGUUUGAA	UUCAAACUCACCCUCCACC	Chmp	[2402-2420]
11	CAUCGGUAAAGCACCUAAA	UUUAGGUGCUUUACCGAUG	Chmp	[372-390]
					12	GAUAAAAGGAGAAUAAGAA	UUCUUAUUCUCCUUUUAUC	Chmp	[1720-1738]
13	GAAUGUUAAGAAUAACUAA	UUAGUUAUUCUUAACAUUC	Chmp	[1298-1316]
					14	CCCUGUUCAUGCUGAGCAA	UUGCUCAGCAUGAACAGGG	Chmp	[1412-1430]
15	GACUAUUCAUCAAGAAUGA	UCAUUCUUGAUGAAUAGUC	Chmp	[2324-2342]
					16	GCGUGUUUCGAUACUGCAA	UUGCAGUAUCGAAACACGC	大鼠，Ms	[1017-1035]
17	GCUGAGUUAUGAAAAGAUA	UAUCUUUUCAUAACUCAGC	Chmp	[1566-1584]
					18	GAAGCUGAUUUUCAUGAAA	UUUCAUGAAAAUCAGCUUC		[1610-1628]
19	CAAUGUUUCUAGAGACAUA	UAUGUCUCUAGAAACAUUG		[1683-1701]
					20	CUGAGUUAUGAAAAGAUAA	UUAUCUUUUCAUAACUCAG	Chmp	[1567-1585]
21	CAUCAAGAAUGAGGAUAUA	UAUAUCCUCAUUCUUGAUG	Chmp	[2331-2349]
					22	CAUGGUGCUGGGACAUGAA	UUCAUGUCCCAGCACCAUG	Chmp	[325-343]
23	GGAUAAUUUUUAAACCAAU	AUUGGUUUAAAAAUUAUCC	Chmp	[1762-1780]
					24	CCAGAAUCCCUGAUGUUAA	UUAACAUCAGGGAUUCUGG	Chmp	[1192-1210]
25	GAUUGCUUUGGGUAAUAAA	UUUAUUACCCAAAGCAAUC	Chmp	[2478-2496]
					26	AGCUGAUUUUCAUGAAAAU	AUUUUCAUGAAAAUCAGCU		[1612-1630]
27	UGGGAAUUUUAUUGUGAAA	UUUCACAAUAAAAUUCCCA	Chmp	[301-319]

28	GGAAUUGGUGUGCCUUAAA	UUUAAGGCACACCAAUUCC	Chmp	[1351-1369]
					29	GAGGGCUGAGUUAUGAAAA	UUUUCAUAACUCAGCCCUC		[1562-1580]
30	GAACUAUCCUAUCCCUGAA	UUCAGGGAUAGGAUAGUUC	Chmp	[199-217]
					31	GGUAAGAUUUAGACCUAAA	UUUAGGUCUAAAUCUUACC		[2278-2296]
32	CGGGAACAGUCGAAAAAGU	ACUUUUUCGACUGUUCCCG	Chmp	[348-366]
					33	UGAGACUAUUCAUCAAGAA	UUCUUGAUGAAUAGUCUCA	Chmp	[2321-2339]
34	CCCAGAAGCUGAUUUUCAU	AUGAAAAUCAGCUUCUGGG		[1606-1624]
					35	GGUUCUGAUUUUCUUGUAA	UUACAAGAAAAUCAGAACC	Chmp	[2423-2441]
36	GGAGAAUAAGAAAAGGCAU	AUGCCUUUUCUUAUUCUCC	Chmp	[1727-1745]
					37	GCAAGAUGGGCCGAUACAA	UUGUAUCGGCCCAUCUUGC	Chmp	[447-465]
38	GGUUAUUAUAAACAGAAAA	UUUUCUGUUUAUAAUAACC	Chmp	[2163-2181]
					39	CCCUAAUGUGGAAAAAGUA	UACUUUUUCCACAUUAGGG	Chmp	[1844-1862]
40	CCAGGAAACUGCUACUUGU	ACAAGUAGCAGUUUCCUGG		[2001-2019]
					41	GCCGGUUCUAUAAGCACAA	UUGUGCUUAUAGAACCGGC	Chmp	[519-537]
42	GGCCUUUGAAACAUUUAAA	UUUAAAUGUUUCAAAGGCC	Chmp	[1129-1147]
					43	UGGUUAUUAUAAACAGAAA	UUUCUGUUUAUAAUAACCA	Chmp	[2162-2180]
44	AGAUUAGCAUCCCAUACUA	UAGUAUGGGAUGCUAAUCU	Chmp	[2078-2096]
					45	GGACAUGAAGCUUCGGGAA	UUCCCGAAGCUUCAUGUCC	Chmp	[335-353]
46	CAGAAUCCCUGAUGUUAAU	AUUAACAUCAGGGAUUCUG	Chmp	[1193-1211]
					47	CAAGUCUGUGAAUGUAAAA	UUUUACAUUCACAGACUUG		[1069-1087]
48	UGAUAAAAGGAGAAUAAGA	UCUUAUUCUCCUUUUAUCA	Chmp	[1719-1737]
					49	GCAGAACUUUCUCUUUUGA	UCAAAAGAGAAAGUUCUGC	Chmp	[1281-1299]
50	GUCGAAUUGGGAAUUUUAU	AUAAAAUUCCCAAUUCGAC	Chmp	[294-312]
					51	UCCGGGAGGUGGAUAUCAA	UUGAUAUCCACCUCCCGGA	Chmp	[996-1014]
52	GGCUGUUUGUUUUGAUGAU	AUCAUCAAAACAAACAGCC	Chmp	[1704-1722]
					53	UGUUUGUUUUGAUGAUAAA	UUUAUCAUCAAAACAAACA	Chmp	[1707-1725]
54	GAGUAUGGUCGAAUUGGGA	UCCCAAUUCGACCAUACUC	Chmp	[287-305]

55	AGAAGAUUAGCAUCCCAUA	UAUGGGAUGCUAAUCUUCU	Chmp	[2075-2093]
					56	CAGAACUUUCUCUUUUGAA	UUCAAAAGAGAAAGUUCUG	Chmp	[1282-1300]
57	AUCGGUAAAGCACCUAAAA	UUUUAGGUGCUUUACCGAU	Chmp	[373-391]
					58	AUAAAAGGAGAAUAAGAAA	UUUCUUAUUCUCCUUUUAU	Chmp	[1721-1739]
59	GCCUUUGAAACAUUUAAAA	UUUUAAAUGUUUCAAAGGC	Chmp	[1130-1148]
					60	GGGUGAGUUUGAAGAGGUU	AACCUCUUCAAACUCACCC	Chmp	[2408-2426]
61	CAAUGUCACCUUUGAGGAA	UUCCUCAAAGGUGACAUUG	Chmp	[565-583]
					62	GGCUGAGUUAUGAAAAGAU	AUCUUUUCAUAACUCAGCC		[1565-1583]
63	AGCUCUGGAGGCCUUUGAA	UUCAAAGGCCUCCAGAGCU	Chmp	[1120-1138]
					64	GGCGUGUUUCGAUACUGCA	UGCAGUAUCGAAACACGCC	大鼠，Ms	[1016-1034]
65	CCUAAUGUGGAAAAAGUAA	UUACUUUUUCCACAUUAGG	Chmp	[1845-1863]
					66	GGGAAUGAGGGCUGAGUUA	UAACUCAGCCCUCAUUCCC		[1556-1574]
67	CUUCCAGUUUAGAACGCAA	UUGCGUUCUAAACUGGAAG		[1667-1685]
					68	GGUGUGCCUUAAAGAUACA	UGUAUCUUUAAGGCACACC	Chmp	[1357-1375]
69	GGGCUGAGUUAUGAAAAGA	UCUUUUCAUAACUCAGCCC		[1564-1582]
					70	CCUGGAGUGCCUUCAUUGA	UCAAUGAAGGCACUCCAGG	Chmp	[1485-1503]
71	AGAAGCUGAUUUUCAUGAA	UUCAUGAAAAUCAGCUUCU		[1609-1627]
					72	GAACUUGUCUUAUUUUAAU	AUUAAAAUAAGACAAGUUC	Chmp	[2243-2261]
73	CCUUCAUUGAGGAAGGAAA	UUUCCUUCCUCAAUGAAGG	Chmp	[1494-1512]
					74	UCUUCUCAUUACCAGUAAA	UUUACUGGUAAUGAGAAGA		[2189-2207]
75	GGUAAAGCACCUAAAACCA	UGGUUUUAGGUGCUUUACC	Chmp	[376-394]
					76	CAAGAUGGGCCGAUACAAU	AUUGUAUCGGCCCAUCUUG	Chmp	[448-466]
77	UUGGGAAUUUUAUUGUGAA	UUCACAAUAAAAUUCCCAA	Chmp	[300-318]
					78	AGGAUAAUUUUUAAACCAA	UUGGUUUAAAAAUUAUCCU	Chmp	[1761-1779]
79	CGCAAUGUUUCUAGAGACA	UGUCUCUAGAAACAUUGCG		[1681-1699]
					80	CAGCACUUCCAGUUUAGAA	UUCUAAACUGGAAGUGCUG	Chmp	[1662-1680]
81	UGACAUAGCUUGAGCUAUA	UAUAGCUCAAGCUAUGUCA	Chmp	[2357-2375]

82	AGGAAUUGGUGUGCCUUAA	UUAAGGCACACCAAUUCCU	Chmp	[1350-1368]
					83	CCAGAAGAUUAGCAUCCCA	UGGGAUGCUAAUCUUCUGG	Chmp	[2073-2091]
84	CUGUUGGAAUGAUUUCUAU	AUAGAAAUCAUUCCAACAG	Chmp	[2224-2242]
					85	CCUUUGAAACAUUUAAAAA	UUUUUAAAUGUUUCAAAGG	Chmp	[1131-1149]
86	UGAGGGCUGAGUUAUGAAA	UUUCAUAACUCAGCCCUCA		[1561-1579]
					87	AAGCUGAUUUUCAUGAAAA	UUUUCAUGAAAAUCAGCUU		[1611-1629]
88	CUGGGAGUAUGGUCGAAUU	AAUUCGACCAUACUCCCAG	Chmp	[283-301]
					89	GAGGAAUUGGUGUGCCUUA	UAAGGCACACCAAUUCCUC	Chmp	[1349-1367]
90	CUGUUUGUUUUGAUGAUAA	UUAUCAUCAAAACAAACAG	Chmp	[1706-1724]
					91	CAGGAUAAUUUUUAAACCA	UGGUUUAAAAAUUAUCCUG	Chmp	[1760-1778]
92	AGGAGAAUAAGAAAAGGCA	UGCCUUUUCUUAUUCUCCU	Chmp	[1726-1744]
					93	CUCAAGUAGUGGUGACUGA	UCAGUCACCACUACUUGAG	Chmp	[723-741]
94	UGAACUUGUCUUAUUUUAA	UUAAAAUAAGACAAGUUCA	Chmp	[2242-2260]
					95	CUUCGGGAACAGUCGAAAA	UUUUCGACUGUUCCCGAAG	Chmp	[345-363]
96	GUGUUUCGAUACUGCAACA	UGUUGCAGUAUCGAAACAC	大鼠，Ms，Chmp	[1019-1037]
					97	GGGCUCUGAUGCAGAACUU	AAGUUCUGCAUCAGAGCCC	Chmp	[1271-1289]
98	GCUCUGGAGGCCUUUGAAA	UUUCAAAGGCCUCCAGAGC	Chmp	[1121-1139]
					99	GGGCCGAUACAAUCUGUCA	UGACAGAUUGUAUCGGCCC	Chmp	[454-472]
100	AGGCCUUUGAAACAUUUAA	UUAAAUGUUUCAAAGGCCU	Chmp	[1128-1146]
					101	GUUACAAGCUUCCUGACAA	UUGUCAGGAAGCUUGUAAC	Chmp	[549-567]
102	UUGGAAUGAUUUCUAUGAA	UUCAUAGAAAUCAUUCCAA	Chmp	[2227-2245]
					103	GAGGAUGCAUUCUGUUGGA	UCCAACAGAAUGCAUCCUC	Chmp	[241-259]
104	CUGACAAUGUCACCUUUGA	UCAAAGGUGACAUUGUCAG	Chmp	[561-579]
					105	AAGUGGGAUCAUCGGUAAA	UUUACCGAUGAUCCCACUU	Chmp	[363-381]
106	GGAUCCAGGAUAAUUUUUA	UAAAAAUUAUCCUGGAUCC	Chmp	[1755-1773]
					107	UGAUGAUAAAAGGAGAAUA	UAUUCUCCUUUUAUCAUCA	Chmp	[1716-1734]
108	ACCUCUGCCGGUUCUAUAA	UUAUAGAACCGGCAGAGGU	Chmp	[513-531]

109	AAAGUGGGAUCAUCGGUAA	UUACCGAUGAUCCCACUUU	Chmp	[362-380]
					110	GGAGGGUUUGGUUAGCUCA	UGAGCUAACCAAACCCUCC	Chmp	[2038-2056]
111	UGGUAAGAUUUAGACCUAA	UUAGGUCUAAAUCUUACCA		[2277-2295]
					112	CCAGGAAAGUAGAAGGUCA	UGACCUUCUACUUUCCUGG		[828-846]
113	AGGAGAGCCCUCAGGAAAU	AUUUCCUGAGGGCUCUCCU	Chmp	[807-825]
					114	GGAGUGCCUUCAUUGAGGA	UCCUCAAUGAAGGCACUCC	Chmp	[1488-1506]
115	CUGGUAAGAUUUAGACCUA	UAGGUCUAAAUCUUACCAG		[2276-2294]
					116	UGGGAUCAUCGGUAAAGCA	UGCUUUACCGAUGAUCCCA	Chmp	[366-384]
117	GAAUGAUUUCUAUGAACUU	AAGUUCAUAGAAAUCAUUC	Chmp	[2230-2248]
					118	CCAACUUGUGACUUUGAGA	UCUCAAAGUCACAAGUUGG	Chmp	[2307-2325]
119	CUCUUCUCAUUACCAGUAA	UUACUGGUAAUGAGAAGAG		[2188-2206]
					120	CCACAGUCUUGGGAUCUCA	UGAGAUCCCAAGACUGUGG		[1229-1247]
121	UGACUUUGAGACUAUUCAU	AUGAAUAGUCUCAAAGUCA	Chmp	[2315-2333]
					122	AGAACUUUCUCUUUUGAAU	AUUCAAAAGAGAAAGUUCU	Chmp	[1283-1301]
123	CAGUGACCAGAAUCCCUGA	UCAGGGAUUCUGGUCACUG	Chmp	[1186-1204]
					124	GAGACUAUUCAUCAAGAAU	AUUCUUGAUGAAUAGUCUC	Chmp	[2322-2340]
125	GGGAAUUUUAUUGUGAAAA	UUUUCACAAUAAAAUUCCC	Chmp	[302-320]
					126	AAGGAGAGCCCUCAGGAAA	UUUCCUGAGGGCUCUCCUU	Chmp	[806-824]
127	AGGGCUGAGUUAUGAAAAG	CUUUUCAUAACUCAGCCCU		[1563-1581]
					128	AUGAGGGCUGAGUUAUGAA	UUCAUAACUCAGCCCUCAU		[1560-1578]
129	GGUUAUUAGACAAUUCCAU	AUGGAAUUGUCUAAUAACC	Chmp	[2136-2154]
					130	GUGGGUUUUUUUUCUGGUA	UACCAGAAAAAAAACCCAC		[2263-2281]
131	GUUUGUUUUGAUGAUAAAA	UUUUAUCAUCAAAACAAAC	Chmp	[1708-1726]
					132	UAAUGUGGAAAAAGUAAGA	UCUUACUUUUUCCACAUUA	Chmp	[1847-1865]
133	AAAUGUCAUGUGAGGUUAA	UUAACCUCACAUGACAUUU	Chmp	[1811-1829]
					134	CUGGUUAUUAUAAACAGAA	UUCUGUUUAUAAUAACCAG	Chmp	[2161-2179]
135	AUACUAGACUCAUACUCAA	UUGAGUAUGAGUCUAGUAU		[2091-2109]

136	GAAAAGAUAACUUCAUGAA	UUCAUGAAGUUAUCUUUUC	Chmp	[1576-1594]
					137	CCAGUAAAGGCUCUUGGUA	UACCAAGAGCCUUUACUGG		[2200-2218]
138	GAUUUAGACCUAAAUCGCA	UGCGAUUUAGGUCUAAAUC		[2283-2301]
					139	AAUUGGUGUGCCUUAAAGA	UCUUUAAGGCACACCAAUU	Chmp	[1353-1371]
140	GUUCUAUAAGCACAAUGCA	UGCAUUGUGCUUAUAGAAC	Chmp	[523-541]
					141	GAGCAAAGUUCAGCAAGUA	UACUUGCUGAACUUUGCUC	Chmp	[1425-1443]
142	GGAAACUGCUACUUGUGGA	UCCACAAGUAGCAGUUUCC		[2004-2022]
					143	UCUUUCUGGUUAUUAUAAA	UUUAUAAUAACCAGAAAGA	Chmp	[2156-2174]
144	CGCCUGGAGAACUAUCCUA	UAGGAUAGUUCUCCAGGCG	Chmp	[191-209]
					145	CCUGGAUCCAGGAUAAUUU	AAAUUAUCCUGGAUCCAGG	Chmp	[1752-1770]
146	GUGACUUUGAGACUAUUCA	UGAAUAGUCUCAAAGUCAC	Chmp	[2314-2332]
					147	CAGUAAAGGCUCUUGGUAU	AUACCAAGAGCCUUUACUG		[2201-2219]
148	AGGUCUUGCUGAGGAUGCA	UGCAUCCUCAGCAAGACCU	Chmp	[231-249]
					149	CCGGUUCUAUAAGCACAAU	AUUGUGCUUAUAGAACCGG	Chmp	[520-538]
150	GGAGUAUGGUCGAAUUGGG	CCCAAUUCGACCAUACUCC	Chmp	[286-304]
					151	AGCAAUGGGAGCAGCUCAA	UUGAGCUGCUCCCAUUGCU	Chmp	[709-727]
152	GAAAAUGAUGAAUUCUGCA	UGCAGAAUUCAUCAUUUUC	Chmp	[431-449]
					153	GAAGAUUGCCUCUUCUACA	UGUAGAAGAGGCAAUCUUC		[1885-1903]
154	UUUCGAUGCUUGCGUCCAA	UUGGACGCAAGCAUCGAAA	GP，Chmp	[1053-1071]
					155	GGUUUUUUUUCUGGUAAGA	UCUUACCAGAAAAAAAACC		[2266-2284]
156	CAAUUCAUUGUGAACAGAA	UUCUGUUCACAAUGAAUUG	Chmp	[1319-1337]
					157	AGUGGUGACUGAUCUGUCU	AGACAGAUCAGUCACCACU	Chmp	[730-748]
158	GGAAAAAGUAAGAGGACUA	UAGUCCUCUUACUUUUUCC		[1853-1871]
					159	CUCUGAGAUGACCACCGUA	UACGGUGGUCAUCUCAGAG	Chmp	[958-976]
160	UUGAGACUAUUCAUCAAGA	UCUUGAUGAAUAGUCUCAA	Chmp	[2320-2338]
					161	CUGGAUCCAGGAUAAUUUU	AAAAUUAUCCUGGAUCCAG	Chmp	[1753-1771]
162	CAGUUUAGAACGCAAUGUU	AACAUUGCGUUCUAAACUG		[1671-1689]

163	GUAAGAUUUAGACCUAAAU	AUUUAGGUCUAAAUCUUAC		[2279-2297]
					164	CUCUGAUGCAGAACUUUCU	AGAAAGUUCUGCAUCAGAG	Chmp	[1274-1292]
165	AAAUCAUGCUCAAGUGUGA	UCACACUUGAGCAUGAUUU		[1164-1182]
					166	CCGAGAAAAUGAUGAAUUC	GAAUUCAUCAUUUUCUCGG	Chmp	[427-445]
167	CAGAUUGCUUUGGGUAAUA	UAUUACCCAAAGCAAUCUG	Chmp	[2476-2494]
					168	UUUUGAUGAUAAAAGGAGA	UCUCCUUUUAUCAUCAAAA	Chmp	[1713-1731]
169	CUGCUACCCGAUUGUCCAA	UUGGACAAUCGGGUAGCAG	Chmp	[747-765]
					170	CUGGGAUGAAGGCUUGUCA	UGACAAGCCUUCAUCCCAG	Chmp	[1645-1663]
171	GGCUCUGAUGCAGAACUUU	AAAGUUCUGCAUCAGAGCC	Chmp	[1272-1290]
					172	GCUUCGGGAACAGUCGAAA	UUUCGACUGUUCCCGAAGC	Chmp	[344-362]
173	AGGUUCUGAUUUUCUUGUA	UACAAGAAAAUCAGAACCU	Chmp	[2422-2440]
					174	CCAAAUGAGGUCUUGCUGA	UCAGCAAGACCUCAUUUGG	Chmp	[224-242]
175	UGGGUUUUUUUUCUGGUAA	UUACCAGAAAAAAAACCCA		[2264-2282]
					176	AAUUGAUGGUUAUUAGACA	UGUCUAAUAACCAUCAAUU	Chmp	[2129-2147]
177	GCACCUAAAACCAGGUGAU	AUCACCUGGUUUUAGGUGC	Chmp	[382-400]
					178	UCACCAGGCAACCAGGAAA	UUUCCUGGUUGCCUGGUGA	Chmp	[1990-2008]
179	GAGUGCCUUCAUUGAGGAA	UUCCUCAAUGAAGGCACUC	Chmp	[1489-1507]
					180	AAUGUCAUGUGAGGUUAAA	UUUAACCUCACAUGACAUU	Chmp	[1812-1830]
181	CGUCCAAGUCUGUGAAUGU	ACAUUCACAGACUUGGACG		[1065-1083]
					182	CUAUGAACUUGUCUUAUUU	AAAUAAGACAAGUUCAUAG	Chmp	[2239-2257]
183	GCCCAGAAGCUGAUUUUCA	UGAAAAUCAGCUUCUGGGC		[1605-1623]
					184	AUCCCAUACUAGACUCAUA	UAUGAGUCUAGUAUGGGAU		[2086-2104]
185	UGAUCUGUCUGCUACCCGA	UCGGGUAGCAGACAGAUCA	Chmp	[739-757]
					186	CUUGAGCUAUAGCCUUUAA	UUAAAGGCUAUAGCUCAAG	Chmp	[2365-2383]
187	UGUGAACAGAAGUCCUUAA	UUAAGGACUUCUGUUCACA		[1327-1345]
					188	UGUGGAAAAAGUAAGAGGA	UCCUCUUACUUUUUCCACA	Chmp	[1850-1868]
189	AAGAGGUUCUGAUUUUCUU	AAGAAAAUCAGAACCUCUU	Chmp	[2419-2437]

190	GAACAGAAGUCCUUAAGCA	UGCUUAAGGACUUCUGUUC		[1330-1348]
					191	UGGUUAUUAGACAAUUCCA	UGGAAUUGUCUAAUAACCA	Chmp	[2135-2153]
192	ACUUGCGCCUGGAGAACUA	UAGUUCUCCAGGCGCAAGU	Chmp	[186-204]
					193	CUUCAUUGAGGAAGGAAAU	AUUUCCUUCCUCAAUGAAG	Chmp	[1495-1513]
194	GAGGCCUUUGAAACAUUUA	UAAAUGUUUCAAAGGCCUC	Chmp	[1127-1145]
					195	UUUCCUGGAUCCAGGAUAA	UUAUCCUGGAUCCAGGAAA	Chmp	[1749-1767]
196	CUUCCUGGAGUGCCUUCAU	AUGAAGGCACUCCAGGAAG	Chmp	[1482-1500]
					197	GGGUUUUUUUUCUGGUAAG	CUUACCAGAAAAAAAACCC		[2265-2283]
198	UCUGGUUAUUAUAAACAGA	UCUGUUUAUAAUAACCAGA	Chmp	[2160-2178]
					199	AGGCUUGUCAGCACUUCCA	UGGAAGUGCUGACAAGCCU	Chmp	[1654-1672]
200	GCAAAGUUCAGCAAGUAGA	UCUACUUGCUGAACUUUGC	Chmp	[1427-1445]
					201	GAAUUUUAUUGUGAAAAAG	CUUUUUCACAAUAAAAUUC	Chmp	[304-322]
202	CUCUUUUGAAUGUUAAGAA	UUCUUAACAUUCAAAAGAG	Chmp	[1291-1309]
					203	CAAUCGGGAUGGUCACUUU	AAAGUGACCAUCCCGAUUG	Chmp	[678-696]
204	CUGAUUUAGUCCUCCAGAU	AUCUGGAGGACUAAAUCAG		[783-801]
					205	GGGCUGAUUUAGUCCUCCA	UGGAGGACUAAAUCAGCCC		[780-798]
206	CUUUCUCUUUUGAAUGUUA	UAACAUUCAAAAGAGAAAG	Chmp	[1287-1305]
					207	UCGAAUUGGGAAUUUUAUU	AAUAAAAUUCCCAAUUCGA	Chmp	[295-313]
208	GGCAACCAGGAAACUGCUA	UAGCAGUUUCCUGGUUGCC	Chmp	[1996-2014]
					209	GUUUGAAGAGGUUCUGAUU	AAUCAGAACCUCUUCAAAC	Chmp	[2414-2432]
210	GGAGAACUAUCCUAUCCCU	AGGGAUAGGAUAGUUCUCC	Chmp	[196-214]
					211	GGAGGCCUUUGAAACAUUU	AAAUGUUUCAAAGGCCUCC	Chmp	[1126-1144]
212	UUACAAGCUUCCUGACAAU	AUUGUCAGGAAGCUUGUAA	Chmp	[550-568]
					213	UAAAAGGAGAAUAAGAAAA	UUUUCUUAUUCUCCUUUUA	Chmp	[1722-1740]
214	AUAGGUUUCCUCUGGAGAA	UUCUCCAGAGGAAACCUAU	Chmp	[1101-1119]
					215	AGAACGCAAUGUUUCUAGA	UCUAGAAACAUUGCGUUCU		[1677-1695]
216	GCUGUUUGUUUUGAUGAUA	UAUCAUCAAAACAAACAGC	Chmp	[1705-1723]

217	AUAACUUCAUGAAGACUUA	UAAGUCUUCAUGAAGUUAU	Chmp	[1582-1600]
					218	AGAUUGCUUUGGGUAAUAA	UUAUUACCCAAAGCAAUCU	Chmp	[2477-2495]
219	GAUGCAGAACUUUCUCUUU	AAAGAGAAAGUUCUGCAUC	Chmp	[1278-1296]
					220	AAUGAUGAAUUCUGCAAGA	UCUUGCAGAAUUCAUCAUU	Chmp	[434-452]
221	UCAUCGGUAAAGCACCUAA	UUAGGUGCUUUACCGAUGA	Chmp	[371-389]
					222	GGCUCAUACUCAAUUGAUG	CAUCAAUUGAGUAUGAGCC	Chmp	[2118-2136]
223	AUUUCUUUCUGGUUAUUAU	AUAAUAACCAGAAAGAAAU	Chmp	[2153-2171]
					224	GUCCAAGUCUGUGAAUGUA	UACAUUCACAGACUUGGAC		[1066-1084]
225	CAUACUCAAUUGAUGGUUA	UAACCAUCAAUUGAGUAUG	Chmp	[2122-2140]
					226	GCUGAUUUAGUCCUCCAGA	UCUGGAGGACUAAAUCAGC		[782-800]
227	CAAAGUUCAGCAAGUAGAG	CUCUACUUGCUGAACUUUG	Chmp	[1428-1446]
					228	GCCUUUAAUUCCUUACUUU	AAAGUAAGGAAUUAAAGGC	Chmp	[2376-2394]
229	GUUUGGUUAGCUCACAGGA	UCCUGUGAGCUAACCAAAC		[2043-2061]
					230	CAGGAAAGUAGAAGGUCAG	CUGACCUUCUACUUUCCUG		[829-847]
231	UCAAUUGAUGGUUAUUAGA	UCUAAUAACCAUCAAUUGA	Chmp	[2127-2145]
					232	GGAUGAAGGCUUGUCAGCA	UGCUGACAAGCCUUCAUCC	Chmp	[1648-1666]
233	CUCCAGAUCUCCAAGGAGA	UCUCCUUGGAGAUCUGGAG	Chmp	[794-812]
					234	GGAGGGUGAGUUUGAAGAG	CUCUUCAAACUCACCCUCC	Chmp	[2405-2423]
235	AGUAUGGUCGAAUUGGGAA	UUCCCAAUUCGACCAUACU	Chmp	[288-306]
					236	GUGACUGAUCUGUCUGCUA	UAGCAGACAGAUCAGUCAC	Chmp	[734-752]
237	UGCUGAGGAUGCAUUCUGU	ACAGAAUGCAUCCUCAGCA	Chmp	[237-255]
					238	UUGGUAUCUUUCUGUUGGA	UCCAACAGAAAGAUACCAA	Chmp	[2213-2231]
239	CCCAUAGGUUUCCUCUGGA	UCCAGAGGAAACCUAUGGG	Chmp	[1098-1116]
					240	GUUGGAAUGAUUUCUAUGA	UCAUAGAAAUCAUUCCAAC	Chmp	[2226-2244]
241	GAAUGAGGGCUGAGUUAUG	CAUAACUCAGCCCUCAUUC		[1558-1576]
					242	UAGGUUUCCUCUGGAGAAA	UUUCUCCAGAGGAAACCUA	Chmp	[1102-1120]
243	GAAUAACUAAUACAAUUCA	UGAAUUGUAUUAGUUAUUC	Chmp	[1307-1325]

244	AAAGAUAACUUCAUGAAGA	UCUUCAUGAAGUUAUCUUU	Chmp	[1578-1596]
					245	CCUCGUCACCCAUAGGUUU	AAACCUAUGGGUGACGAGG	Chmp	[1090-1108]
246	UCAAGGGCGUGUUUCGAUA	UAUCGAAACACGCCCUUGA		[1011-1029]
					247	AGGCAACCAGGAAACUGCU	AGCAGUUUCCUGGUUGCCU	Chmp	[1995-2013]
248	CAUACUAGACUCAUACUCA	UGAGUAUGAGUCUAGUAUG		[2090-2108]
					249	GGUGGGUUUUUUUUCUGGU	ACCAGAAAAAAAACCCACC		[2262-2280]
250	CGAGAAAAUGAUGAAUUCU	AGAAUUCAUCAUUUUCUCG	Chmp	[428-446]
					251	AGACCAGGAGGGUUUGGUU	AACCAAACCCUCCUGGUCU	Chmp	[2032-2050]
252	AGGGUUUGGUUAGCUCACA	UGUGAGCUAACCAAACCCU	Chmp	[2040-2058]
					253	CUCAAUUGAUGGUUAUUAG	CUAAUAACCAUCAAUUGAG	Chmp	[2126-2144]
254	AGACUCAUACUCAACUCAA	UUGAGUUGAGUAUGAGUCU		[2096-2114]
					255	CAACCAGGAAACUGCUACU	AGUAGCAGUUUCCUGGUUG		[1998-2016]
256	AAUGCAGCCUUUUGUUACA	UGUAACAAAAGGCUGCAUU	Chmp	[536-554]
					257	CUUGUGACUUUGAGACUAU	AUAGUCUCAAAGUCACAAG	Chmp	[2311-2329]
258	GAGGUUAAACCAGUUUGCA	UGCAAACUGGUUUAACCUC	Chmp	[1822-1840]
					259	GGGUUUGGUUAGCUCACAG	CUGUGAGCUAACCAAACCC		[2041-2059]
260	UAAUACAAUUCAUUGUGAA	UUCACAAUGAAUUGUAUUA	Chmp	[1314-1332]
					261	CUAUCCUAUCCCUGAACCA	UGGUUCAGGGAUAGGAUAG	Chmp	[202-220]
262	UGGUAUCUUUCUGUUGGAA	UUCCAACAGAAAGAUACCA	Chmp	[2214-2232]
					263	GAGUUUGAAGAGGUUCUGA	UCAGAACCUCUUCAAACUC	Chmp	[2412-2430]
264	UGGUGUGCCUUAAAGAUAC	GUAUCUUUAAGGCACACCA	Chmp	[1356-1374]
					265	UGCCGGUUCUAUAAGCACA	UGUGCUUAUAGAACCGGCA	Chmp	[518-536]
266	AUUGAUGGUUAUUAGACAA	UUGUCUAAUAACCAUCAAU	Chmp	[2130-2148]
					267	UUUCUUUCUGGUUAUUAUA	UAUAAUAACCAGAAAGAAA	Chmp	[2154-2172]
268	AUUGGUGUGCCUUAAAGAU	AUCUUUAAGGCACACCAAU	Chmp	[1354-1372]
					269	UGAUUUUCAUGAAAAUCUG	CAGAUUUUCAUGAAAAUCA		[1615-1633]
270	GACCAGGAGGGUUUGGUUA	UAACCAAACCCUCCUGGUC	Chmp	[2033-2051]

271	AAUGGGAGCAGCUCAAGUA	UACUUGAGCUGCUCCCAUU	Chmp	[712-730]
					272	UUUCGAUACUGCAACACGU	ACGUGUUGCAGUAUCGAAA	大鼠，Ms，Chmp	[1022-1040]
273	UAUUCAUCAAGAAUGAGGA	UCCUCAUUCUUGAUGAAUA	Chmp	[2327-2345]
					274	CCUGUUCAUGCUGAGCAAA	UUUGCUCAGCAUGAACAGG	Chmp	[1413-1431]
275	AAUGAGGGCUGAGUUAUGA	UCAUAACUCAGCCCUCAUU		[1559-1577]
					276	AACCUCUGCCGGUUCUAUA	UAUAGAACCGGCAGAGGUU	Chmp	[512-530]
277	UUUCUCUUUUGAAUGUUAA	UUAACAUUCAAAAGAGAAA	Chmp	[1288-1306]
					278	UGGUCGAAUUGGGAAUUUU	AAAAUUCCCAAUUCGACCA	Chmp	[292-310]
279	CAGAGGAAUUGGUGUGCCU	AGGCACACCAAUUCCUCUG	Chmp	[1347-1365]
					280	CAAGCUUCCUGACAAUGUC	GACAUUGUCAGGAAGCUUG	Chmp	[553-571]
281	UAAGCAUGGUCCCUUGUCA	UGACAAGGGACCAUGCUUA		[1974-1992]
					282	GAUACAAUCUGGGAUAGUU	AACUAUCCCAGAUUGUAUC	Chmp	[1370-1388]
283	CGGUAAAGCACCUAAAACC	GGUUUUAGGUGCUUUACCG	Chmp	[375-393]
					284	GAUCAUCGGUAAAGCACCU	AGGUGCUUUACCGAUGAUC	Chmp	[369-387]
285	GCACAAUGCAGCCUUUUGU	ACAAAAGGCUGCAUUGUGC	Chmp	[532-550]
					286	GCCUGGAGAACUAUCCUAU	AUAGGAUAGUUCUCCAGGC	Chmp	[192-210]
287	AAAGGCUCUUGGUAUCUUU	AAAGAUACCAAGAGCCUUU	Chmp	[2205-2223]
					288	AAAUCUUUCCUCUUCUCAU	AUGAGAAGAGGAAAGAUUU	Chmp	[2179-2197]
289	CACAAUGCAGCCUUUUGUU	AACAAAAGGCUGCAUUGUG	Chmp	[533-551]
					290	CAGAAGAUUAGCAUCCCAU	AUGGGAUGCUAAUCUUCUG	Chmp	[2074-2092]
291	GACUCAUACUCAACUCAAC	GUUGAGUUGAGUAUGAGUC		[2097-2115]
					292	GGGUUGAAAAUCAUGCUCA	UGAGCAUGAUUUUCAACCC		[1157-1175]
293	GAAACAUUUAAAAAGGGAU	AUCCCUUUUUAAAUGUUUC	Chmp	[1136-1154]
					294	GAAUUGGUGUGCCUUAAAG	CUUUAAGGCACACCAAUUC	Chmp	[1352-1370]
295	AGAACUAUCCUAUCCCUGA	UCAGGGAUAGGAUAGUUCU	Chmp	[198-216]
					296	AGGUUAAACCAGUUUGCAU	AUGCAAACUGGUUUAACCU	Chmp	[1823-1841]
297	CUGAACCAGGCCCAAAUGA	UCAUUUGGGCCUGGUUCAG	Chmp	[213-231]

298	GUAAGAGGACUACUCAGCA	UGCUGAGUAGUCCUCUUAC		[1860-1878]
					299	CGAUACAAUCUGUCACCUU	AAGGUGACAGAUUGUAUCG	Chmp	[458-476]
300	AAGGCAUCACUUUCCUGGA	UCCAGGAAAGUGAUGCCUU	Chmp	[1739-1757]
					301	UCGGGAUGGUCACUUUGCU	AGCAAAGUGACCAUCCCGA	Chmp	[681-699]
302	UGUUUUGAUGAUAAAAGGA	UCCUUUUAUCAUCAAAACA	Chmp	[1711-1729]
					303	AAGUAGUGGUGACUGAUCU	AGAUCAGUCACCACUACUU	Chmp	[726-744]
304	CUUUCUGUUGGAAUGAUUU	AAAUCAUUCCAACAGAAAG	Chmp	[2220-2238]
					305	AGACCUAAAUCGCAUCAUG	CAUGAUGCGAUUUAGGUCU		[2288-2306]
306	ACAUGAAGCUUCGGGAACA	UGUUCCCGAAGCUUCAUGU	Chmp	[337-355]
					307	UUCGGGAACAGUCGAAAAA	UUUUUCGACUGUUCCCGAA	Chmp	[346-364]
308	GGAUAUCAAGGGCGUGUUU	AAACACGCCCUUGAUAUCC		[1006-1024]
					309	UCUGUUGGAAUGAUUUCUA	UAGAAAUCAUUCCAACAGA	Chmp	[2223-2241]
310	AGGCUCAUACUCAAUUGAU	AUCAAUUGAGUAUGAGCCU	Chmp	[2117-2135]
					311	CUGUCACCUUCCAUCUUCU	AGAAGAUGGAAGGUGACAG	Chmp	[467-485]
312	UUUGAUGAUAAAAGGAGAA	UUCUCCUUUUAUCAUCAAA	Chmp	[1714-1732]
					313	CUACUGGGAGUAUGGUCGA	UCGACCAUACUCCCAGUAG	Chmp	[280-298]
314	CAACUCAACUAGGCUCAUA	UAUGAGCCUAGUUGAGUUG	Chmp	[2107-2125]
					315	AACGCAAUGUUUCUAGAGA	UCUCUAGAAACAUUGCGUU		[1679-1697]
316	GAACCUCUGCCGGUUCUAU	AUAGAACCGGCAGAGGUUC	Chmp	[511-529]
					317	AUGAGGUCUUGCUGAGGAU	AUCCUCAGCAAGACCUCAU	Chmp	[228-246]
318	GUGUGCCUUAAAGAUACAA	UUGUAUCUUUAAGGCACAC	Chmp	[1358-1376]
					319	GUAUGGUCGAAUUGGGAAU	AUUCCCAAUUCGACCAUAC	Chmp	[289-307]
320	GCUUGUCAGCACUUCCAGU	ACUGGAAGUGCUGACAAGC	Chmp	[1656-1674]
					321	ACUUGUGGACCUCACCAGA	UCUGGUGAGGUCCACAAGU		[2014-2032]
322	AGCUUCGGGAACAGUCGAA	UUCGACUGUUCCCGAAGCU	Chmp	[343-361]
					323	GGAUGGUCACUUUGCUCGU	ACGAGCAAAGUGACCAUCC	Chmp	[684-702]
324	UCAAGUAGUGGUGACUGAU	AUCAGUCACCACUACUUGA	Chmp	[724-742]

325	UUGGUGUGCCUUAAAGAUA	UAUCUUUAAGGCACACCAA	Chmp	[1355-1373]
					326	UCCAAGUCUGUGAAUGUAA	UUACAUUCACAGACUUGGA		[1067-1085]
327	UCAUCAAGAAUGAGGAUAU	AUAUCCUCAUUCUUGAUGA	Chmp	[2330-2348]
					328	CAUGUGAGGUUAAACCAGU	ACUGGUUUAACCUCACAUG	Chmp	[1817-1835]
329	UGCAAGAUGGGCCGAUACA	UGUAUCGGCCCAUCUUGCA	Chmp	[446-464]
					330	AAAGUAAGAGGACUACUCA	UGAGUAGUCCUCUUACUUU		[1857-1875]
331	CACUUUCCUGGAUCCAGGA	UCCUGGAUCCAGGAAAGUG	Chmp	[1746-1764]
					332	GACCAGAAUCCCUGAUGUU	AACAUCAGGGAUUCUGGUC	Chmp	[1190-1208]
333	UCUGCAAGAUGGGCCGAUA	UAUCGGCCCAUCUUGCAGA	Chmp	[444-462]
					334	GCCCAAAUGAGGUCUUGCU	AGCAAGACCUCAUUUGGGC	Chmp	[222-240]
335	CCUCUUCUCAUUACCAGUA	UACUGGUAAUGAGAAGAGG		[2187-2205]
					336	AUCCAGGAUAAUUUUUAAA	UUUAAAAAUUAUCCUGGAU	Chmp	[1757-1775]
337	GAGUUAUGAAAAGAUAACU	AGUUAUCUUUUCAUAACUC	Chmp	[1569-1587]
					338	GCUGAGGAUGCAUUCUGUU	AACAGAAUGCAUCCUCAGC	Chmp	[238-256]
339	AGUUUAGAACGCAAUGUUU	AAACAUUGCGUUCUAAACU		[1672-1690]
					340	CCCGAGAAAAUGAUGAAUU	AAUUCAUCAUUUUCUCGGG	Chmp	[426-444]
341	UUAUGAAAAGAUAACUUCA	UGAAGUUAUCUUUUCAUAA	Chmp	[1572-1590]
					342	UAAGAAAAGGCAUCACUUU	AAAGUGAUGCCUUUUCUUA	Chmp	[1733-1751]
343	CAAUGGGAGCAGCUCAAGU	ACUUGAGCUGCUCCCAUUG	Chmp	[711-729]
					344	UAUGAAAAGAUAACUUCAU	AUGAAGUUAUCUUUUCAUA	Chmp	[1573-1591]
345	UCAAGAAUGAGGAUAUAGU	ACUAUAUCCUCAUUCUUGA	Chmp	[2333-2351]
					346	GGAAUGAUUUCUAUGAACU	AGUUCAUAGAAAUCAUUCC	Chmp	[2229-2247]
347	GUCAUGUGAGGUUAAACCA	UGGUUUAACCUCACAUGAC	Chmp	[1815-1833]
					348	AUAAGAAAAGGCAUCACUU	AAGUGAUGCCUUUUCUUAU	Chmp	[1732-1750]
349	ACUCAGGGUCUGGGAUGAA	UUCAUCCCAGACCCUGAGU	Chmp	[1636-1654]
					350	AGUUUGAAGAGGUUCUGAU	AUCAGAACCUCUUCAAACU	Chmp	[2413-2431]
351	GGUUAAACCAGUUUGCAUU	AAUGCAAACUGGUUUAACC	Chmp	[1824-1842]

352	UUGUGGACCUCACCAGAGA	UCUCUGGUGAGGUCCACAA		[2016-2034]
					353	CAGCAAGUAGAGCAGAGUU	AACUCUGCUCUACUUGCUG	Chmp	[1435-1453]
354	CUAAUACAAUUCAUUGUGA	UCACAAUGAAUUGUAUUAG	Chmp	[1313-1331]
					355	UCUUUUGAAUGUUAAGAAU	AUUCUUAACAUUCAAAAGA	Chmp	[1292-1310]
356	GUGCCCGAUUCUUUCAGAU	AUCUGAAAGAAUCGGGCAC	Chmp	[2462-2480]
					357	UUGGGAUCUCAGGGCACAA	UUGUGCCCUGAGAUCCCAA		[1237-1255]
358	GCAGCUCAAGUAGUGGUGA	UCACCACUACUUGAGCUGC	Chmp	[719-737]
					359	CACAGUCUUGGGAUCUCAG	CUGAGAUCCCAAGACUGUG		[1230-1248]
360	CAUGAAGCUUCGGGAACAG	CUGUUCCCGAAGCUUCAUG	Chmp	[338-356]
					361	GGAAUGAGGGCUGAGUUAU	AUAACUCAGCCCUCAUUCC		[1557-1575]
362	UGAAUGUUAAGAAUAACUA	UAGUUAUUCUUAACAUUCA	Chmp	[1297-1315]
					363	UGAAAAGAUAACUUCAUGA	UCAUGAAGUUAUCUUUUCA	Chmp	[1575-1593]
364	GAAGAGGUUCUGAUUUUCU	AGAAAAUCAGAACCUCUUC	Chmp	[2418-2436]
					365	GGUCUUGCUGAGGAUGCAU	AUGCAUCCUCAGCAAGACC	Chmp	[232-250]
366	CAUGACAUAGCUUGAGCUA	UAGCUCAAGCUAUGUCAUG	Chmp	[2355-2373]
					367	UGGGUUUCCUGGUUCCACU	AGUGGAACCAGGAAACCCA	Chmp	[1522-1540]
368	CCAACAACCUUUCCCUGGU	ACCAGGGAAAGGUUGUUGG	Chmp	[150-168]
					369	AUUAGCAUCCCAUACUAGA	UCUAGUAUGGGAUGCUAAU		[2080-2098]
370	AAAGAUACAAUCUGGGAUA	UAUCCCAGAUUGUAUCUUU	Chmp	[1367-1385]
					371	CCUCUUCUACAGCUUCUGA	UCAGAAGCUGUAGAAGAGG		[1893-1911]
372	UUGCGUCCAAGUCUGUGAA	UUCACAGACUUGGACGCAA	Chmp	[1062-1080]
					373	UACUGGGAGUAUGGUCGAA	UUCGACCAUACUCCCAGUA	Chmp	[281-299]
374	CAUUGUGAACAGAAGUCCU	AGGACUUCUGUUCACAAUG	Chmp	[1324-1342]
					375	AUGAACUUGUCUUAUUUUA	UAAAAUAAGACAAGUUCAU	Chmp	[2241-2259]
376	GGCUCUUGGUAUCUUUCUG	CAGAAAGAUACCAAGAGCC	Chmp	[2208-2226]
					377	GGGAACAGUCGAAAAAGUG	CACUUUUUCGACUGUUCCC	Chmp	[349-367]
378	UGAAACAUUUAAAAAGGGA	UCCCUUUUUAAAUGUUUCA	Chmp	[1135-1153]

379	AACUAGGCUCAUACUCAAU	AUUGAGUAUGAGCCUAGUU	Chmp	[2113-2131]
					380	AAUCUUUCCUCUUCUCAUU	AAUGAGAAGAGGAAAGAUU	Chmp	[2180-2198]
381	UCUGGAGGCCUUUGAAACA	UGUUUCAAAGGCCUCCAGA	Chmp	[1123-1141]
					382	AUGUGAGGUUAAACCAGUU	AACUGGUUUAACCUCACAU	Chmp	[1818-1836]
383	CUUCUACAGCUUCUGAGAA	UUCUCAGAAGCUGUAGAAG		[1896-1914]
					384	UGUCAGCACUUCCAGUUUA	UAAACUGGAAGUGCUGACA	Chmp	[1659-1677]
385	UCAACUAGGCUCAUACUCA	UGAGUAUGAGCCUAGUUGA	Chmp	[2111-2129]
					386	GGCUCAGAUGUCCACUACU	AGUAGUGGACAUCUGAGCC	Chmp	[266-284]
387	UUUCUAUGAACUUGUCUUA	UAAGACAAGUUCAUAGAAA	Chmp	[2236-2254]
					388	CAGGAAACUGCUACUUGUG	CACAAGUAGCAGUUUCCUG		[2002-2020]
389	GCAUUCUGUUGGAAUCUGU	ACAGAUUCCAACAGAAUGC	Chmp	[247-265]
					390	CGUGUUUCGAUACUGCAAC	GUUGCAGUAUCGAAACACG	大鼠，Ms	[1018-1036]
391	CCAGGAUAAUUUUUAAACC	GGUUUAAAAAUUAUCCUGG	Chmp	[1759-1777]
					392	UUGUGACUUUGAGACUAUU	AAUAGUCUCAAAGUCACAA	Chmp	[2312-2330]
393	AAAAGUGGGAUCAUCGGUA	UACCGAUGAUCCCACUUUU	Chmp	[361-379]
					394	UCUGCUACCCGAUUGUCCA	UGGACAAUCGGGUAGCAGA	Chmp	[746-764]
395	UAACUUCAUGAAGACUUAA	UUAAGUCUUCAUGAAGUUA	Chmp	[1583-1601]
					396	GCUGAGCAAAGUUCAGCAA	UUGCUGAACUUUGCUCAGC	Chmp	[1422-1440]
397	UAGUCCUCCAGAUCUCCAA	UUGGAGAUCUGGAGGACUA		[789-807]
					398	ACCAGUAAAGGCUCUUGGU	ACCAAGAGCCUUUACUGGU		[2199-2217]
399	GAAGAUUAGCAUCCCAUAC	GUAUGGGAUGCUAAUCUUC	Chmp	[2076-2094]
					400	CAUGCUGAGCAAAGUUCAG	CUGAACUUUGCUCAGCAUG	Chmp	[1419-1437]
401	AGCCUUUAAUUCCUUACUU	AAGUAAGGAAUUAAAGGCU	Chmp	[2375-2393]
					402	AGAAUAAGAAAAGGCAUCA	UGAUGCCUUUUCUUAUUCU	Chmp	[1729-1747]
403	CUCUGGAGAAAGCUCUGGA	UCCAGAGCUUUCUCCAGAG	Chmp	[1110-1128]
					404	UGAGCUAUAGCCUUUAAUU	AAUUAAAGGCUAUAGCUCA	Chmp	[2367-2385]
405	UAGGCUCAUACUCAAUUGA	UCAAUUGAGUAUGAGCCUA	Chmp	[2116-2134]

406	AAUUCAUUGUGAACAGAAG	CUUCUGUUCACAAUGAAUU	Chmp	[1320-1338]
					407	CCAUUUCUUUCUGGUUAUU	AAUAACCAGAAAGAAAUGG	Chmp	[2151-2169]
408	GAGGGUUUGGUUAGCUCAC	GUGAGCUAACCAAACCCUC	Chmp	[2039-2057]
					409	CUUUUGAAUGUUAAGAAUA	UAUUCUUAACAUUCAAAAG	Chmp	[1293-1311]
410	AAGCAAUGGGAGCAGCUCA	UGAGCUGCUCCCAUUGCUU	Chmp	[708-726]
					411	CUGGUUCCACUGCUACUGA	UCAGUAGCAGUGGAACCAG	Chmp	[1530-1548]
412	CAUAGGUUUCCUCUGGAGA	UCUCCAGAGGAAACCUAUG	Chmp	[1100-1118]
					413	CAAAUGAGGUCUUGCUGAG	CUCAGCAAGACCUCAUUUG	Chmp	[225-243]
414	UGUGCCCGAUUCUUUCAGA	UCUGAAAGAAUCGGGCACA	Chmp	[2461-2479]
					415	AAGCUUCCUGACAAUGUCA	UGACAUUGUCAGGAAGCUU	Chmp	[554-572]
416	UUUUCUGGUAAGAUUUAGA	UCUAAAUCUUACCAGAAAA		[2272-2290]
					417	GAUCUGUCUGCUACCCGAU	AUCGGGUAGCAGACAGAUC	Chmp	[740-758]
418	AGGCAUCACUUUCCUGGAU	AUCCAGGAAAGUGAUGCCU	Chmp	[1740-1758]
					419	AAGCUUCGGGAACAGUCGA	UCGACUGUUCCCGAAGCUU	Chmp	[342-360]
420	ACUUGUGACUUUGAGACUA	UAGUCUCAAAGUCACAAGU	Chmp	[2310-2328]
					421	GGCCGAUACAAUCUGUCAC	GUGACAGAUUGUAUCGGCC	Chmp	[455-473]
422	UGGAGGGUGAGUUUGAAGA	UCUUCAAACUCACCCUCCA	Chmp	[2404-2422]
					423	CUUUCUGGUUAUUAUAAAC	GUUUAUAAUAACCAGAAAG	Chmp	[2157-2175]
424	AGCCCAACAACCUUUCCCU	AGGGAAAGGUUGUUGGGCU	Chmp	[147-165]
					425	GUCGAAAAAGUGGGAUCAU	AUGAUCCCACUUUUUCGAC	Chmp	[356-374]
426	UGCAGAACUUUCUCUUUUG	CAAAAGAGAAAGUUCUGCA	Chmp	[1280-1298]
					427	CAGCUCAAGUAGUGGUGAC	GUCACCACUACUUGAGCUG	Chmp	[720-738]
428	AGCCUUUUGUUACAAGCUU	AAGCUUGUAACAAAAGGCU	Chmp	[541-559]
					429	GGAUGCAUUCUGUUGGAAU	AUUCCAACAGAAUGCAUCC	Chmp	[243-261]
430	GAAAAGGCAUCACUUUCCU	AGGAAAGUGAUGCCUUUUC	Chmp	[1736-1754]
					431	CGAAAAAGUGGGAUCAUCG	CGAUGAUCCCACUUUUUCG	Chmp	[358-376]
432	GCUUGAGCUAUAGCCUUUA	UAAAGGCUAUAGCUCAAGC	Chmp	[2364-2382]

433	ACUUUGAGACUAUUCAUCA	UGAUGAAUAGUCUCAAAGU	Chmp	[2317-2335]
					434	AUACUCAAUUGAUGGUUAU	AUAACCAUCAAUUGAGUAU	Chmp	[2123-2141]
435	UGAGCAAAGUUCAGCAAGU	ACUUGCUGAACUUUGCUCA	Chmp	[1424-1442]
					436	UGACAAUGUCACCUUUGAG	CUCAAAGGUGACAUUGUCA	Chmp	[562-580]
437	ACUCAGCACUGUUUGAAGA	UCUUCAAACAGUGCUGAGU		[1871-1889]
					438	UGACCUUGUGCCCGAUUCU	AGAAUCGGGCACAAGGUCA	Chmp	[2455-2473]
439	AUACAAUCUGGGAUAGUUU	AAACUAUCCCAGAUUGUAU	Chmp	[1371-1389]
					440	GUGAGUUUGAAGAGGUUCU	AGAACCUCUUCAAACUCAC	Chmp	[2410-2428]
441	CAGAAGCUGAUUUUCAUGA	UCAUGAAAAUCAGCUUCUG		[1608-1626]
					442	AAUGGUGGGUUUUUUUUCU	AGAAAAAAAACCCACCAUU		[2259-2277]
443	CAGCCUUUUGUUACAAGCU	AGCUUGUAACAAAAGGCUG	Chmp	[540-558]
					444	GUGGGAUCAUCGGUAAAGC	GCUUUACCGAUGAUCCCAC	Chmp	[365-383]
445	CCUGGAGAACUAUCCUAUC	GAUAGGAUAGUUCUCCAGG	Chmp	[193-211]
					446	UCCAUUUCUUUCUGGUUAU	AUAACCAGAAAGAAAUGGA	Chmp	[2150-2168]
447	CAAGUAGAGCAGAGUUUGG	CCAAACUCUGCUCUACUUG	Chmp	[1438-1456]
					448	AAGUCCUUAAGCAGAGGAA	UUCCUCUGCUUAAGGACUU		[1336-1354]
449	CUUUCAGAUUGCUUUGGGU	ACCCAAAGCAAUCUGAAAG	Chmp	[2472-2490]
					450	GGAUCAUCGGUAAAGCACC	GGUGCUUUACCGAUGAUCC	Chmp	[368-386]
451	CGAAUUGGGAAUUUUAUUG	CAAUAAAAUUCCCAAUUCG	Chmp	[296-314]
					452	GGCUGAUUUAGUCCUCCAG	CUGGAGGACUAAAUCAGCC		[781-799]
453	GAUGAAGGCUUGUCAGCAC	GUGCUGACAAGCCUUCAUC	Chmp	[1649-1667]
					454	UCAGCACUUCCAGUUUAGA	UCUAAACUGGAAGUGCUGA	Chmp	[1661-1679]
455	GGAACAGUCGAAAAAGUGG	CCACUUUUUCGACUGUUCC	Chmp	[350-368]
					456	UCAUGCUGAGCAAAGUUCA	UGAACUUUGCUCAGCAUGA	Chmp	[1418-1436]
457	GGAAAUGUCAUGUGAGGUU	AACCUCACAUGACAUUUCC	Chmp	[1809-1827]
					458	UACAAUCUGUCACCUUCCA	UGGAAGGUGACAGAUUGUA	Chmp	[461-479]
459	GAUUAGCAUCCCAUACUAG	CUAGUAUGGGAUGCUAAUC	Chmp	[2079-2097]

460	CCUAAAACCAGGUGAUCGU	ACGAUCACCUGGUUUUAGG	Chmp	[385-403]
					461	UCUUCUACAGCUUCUGAGA	UCUCAGAAGCUGUAGAAGA		[1895-1913]
462	UCUUUCUGUUGGAAUGAUU	AAUCAUUCCAACAGAAAGA	Chmp	[2219-2237]
					463	CUUGCGUCCAAGUCUGUGA	UCACAGACUUGGACGCAAG	Chmp	[1061-1079]
464	UGCCUUCAUUGAGGAAGGA	UCCUUCCUCAAUGAAGGCA	Chmp	[1492-1510]
					465	UGACCAGAAUCCCUGAUGU	ACAUCAGGGAUUCUGGUCA	Chmp	[1189-1207]
466	GGUAUCUUUCUGUUGGAAU	AUUCCAACAGAAAGAUACC	Chmp	[2215-2233]
					467	GUUAAGAAUAACUAAUACA	UGUAUUAGUUAUUCUUAAC	Chmp	[1302-1320]
468	AAGCUCUGGAGGCCUUUGA	UCAAAGGCCUCCAGAGCUU	Chmp	[1119-1137]
					469	AUUUAGACCUAAAUCGCAU	AUGCGAUUUAGGUCUAAAU		[2284-2302]
470	GUUAUUAGACAAUUCCAUU	AAUGGAAUUGUCUAAUAAC	Chmp	[2137-2155]
					471	UUCUUUCUGGUUAUUAUAA	UUAUAAUAACCAGAAAGAA	Chmp	[2155-2173]
472	AAAGGAGAAUAAGAAAAGG	CCUUUUCUUAUUCUCCUUU	Chmp	[1724-1742]
					473	UGGAGGCCUUUGAAACAUU	AAUGUUUCAAAGGCCUCCA	Chmp	[1125-1143]
474	UGAACCAGGCCCAAAUGAG	CUCAUUUGGGCCUGGUUCA	Chmp	[214-232]
					475	AUUGGGAAUUUUAUUGUGA	UCACAAUAAAAUUCCCAAU	Chmp	[299-317]
476	UUCAGAUUGCUUUGGGUAA	UUACCCAAAGCAAUCUGAA	Chmp	[2474-2492]
					477	CCUUGUGCCCGAUUCUUUC	GAAAGAAUCGGGCACAAGG	Chmp	[2458-2476]
478	CUGAUUUUCAUGAAAAUCU	AGAUUUUCAUGAAAAUCAG		[1614-1632]
					479	CGGUUCUAUAAGCACAAUG	CAUUGUGCUUAUAGAACCG	Chmp	[521-539]
480	UGAUGCAGAACUUUCUCUU	AAGAGAAAGUUCUGCAUCA	Chmp	[1277-1295]
					481	AGUUAUGAAAAGAUAACUU	AAGUUAUCUUUUCAUAACU	Chmp	[1570-1588]
482	GGACUACUCAGCACUGUUU	AAACAGUGCUGAGUAGUCC		[1866-1884]
					483	ACAGAAGUCCUUAAGCAGA	UCUGCUUAAGGACUUCUGU		[1332-1350]
484	ACUUCAUGAAGACUUAACU	AGUUAAGUCUUCAUGAAGU	Chmp	[1585-1603]
					485	UGAUGGUUAUUAGACAAUU	AAUUGUCUAAUAACCAUCA	Chmp	[2132-2150]
486	AUUCAUCAAGAAUGAGGAU	AUCCUCAUUCUUGAUGAAU	Chmp	[2328-2346]

487	CCAUAGGUUUCCUCUGGAG	CUCCAGAGGAAACCUAUGG	Chmp	[1099-1117]
					488	GCCUUCAUUGAGGAAGGAA	UUCCUUCCUCAAUGAAGGC	Chmp	[1493-1511]
489	AUGGGUGGAGGGUGAGUUU	AAACUCACCCUCCACCCAU	Chmp	[2399-2417]
					490	UAGACAAUUCCAUUUCUUU	AAAGAAAUGGAAUUGUCUA	Chmp	[2142-2160]
491	UGGUUAGCUCACAGGACUU	AAGUCCUGUGAGCUAACCA		[2046-2064]
					492	ACGCAAUGUUUCUAGAGAC	GUCUCUAGAAACAUUGCGU		[1680-1698]
493	AACAGUCGAAAAAGUGGGA	UCCCACUUUUUCGACUGUU	Chmp	[352-370]
					494	CCAGAAGCUGAUUUUCAUG	CAUGAAAAUCAGCUUCUGG		[1607-1625]
495	ACUCAACUAGGCUCAUACU	AGUAUGAGCCUAGUUGAGU	Chmp	[2109-2127]
					496	CCAUGACAUAGCUUGAGCU	AGCUCAAGCUAUGUCAUGG	Chmp	[2354-2372]
497	ACAAUGUCACCUUUGAGGA	UCCUCAAAGGUGACAUUGU	Chmp	[564-582]
					498	UGGAAUGAUUUCUAUGAAC	GUUCAUAGAAAUCAUUCCA	Chmp	[2228-2246]
499	ACUACUCAGCACUGUUUGA	UCAAACAGUGCUGAGUAGU		[1868-1886]
					500	CAAGUAGUGGUGACUGAUC	GAUCAGUCACCACUACUUG	Chmp	[725-743]

表B 33SOX9-SRY(性别决定区域Y)-箱9

No.	正义链siRNA	反义链siRNA	其他Sp	人-37704387：373-1902
					1	GGAGGAAGUCGGUGAAGAA	UUCUUCACCGACUUCCUCC	Ms	[905-923]
2	GGAGGAGCUGCCUUAAAAA	UUUUUAAGGCAGCUCCUCC		[2624-2642]
					3	GGAGCUGCCUUAAAAAAAA	UUUUUUUUAAGGCAGCUCC		[2627-2645]
4	CGUGGAGGAUGAUGGAGAA	UUCUCCAUCAUCCUCCACG		[2216-2234]
					5	CGAGAAACUGGACUUUUUA	UAAAAAGUCCAGUUUCUCG		[2179-2197]
6	GGAGAGGUUUUAAUUAAAA	UUUUAAUUAAAACCUCUCC		[3038-3056]
					7	GCUCGAAACUGACUGGAAA	UUUCCAGUCAGUUUCGAGC		[18-36]
8	CCGAGAUGAUCCUAAAAAU	AUUUUUAGGAUCAUCUCGG		[1931-1949]
					9	AGGAGAGGUUUUAAUUAAA	UUUAAUUAAAACCUCUCCU		[3037-3055]
10	GGCCGAGAUGAUCCUAAAA	UUUUAGGAUCAUCUCGGCC		[1929-1947]
					11	AGGAGGAGCUGCCUUAAAA	UUUUAAGGCAGCUCCUCCU		[2623-2641]

12	CGAGAUGAUCCUAAAAAUA	UAUUUUUAGGAUCAUCUCG		[1932-1950]
					13	GAGAAACUGGACUUUUUAA	UUAAAAAGUCCAGUUUCUC		[2180-2198]
14	GGAAUAUUCUCUAUUUUAA	UUAAAAUAGAGAAUAUUCC	Ms	[2323-2341]
					15	AGCAGUAAUUAAAGAAAAA	UUUUUCUUUAAUUACUGCU		[2292-2310]
16	GUGUGAUCAGUGUGCUAAA	UUUAGCACACUGAUCACAC		[2237-2255]
					17	AGAAGUCAGUAGAAUAAAA	UUUUAUUCUACUGACUUCU	Ms	[3640-3658]
18	CCACCUUCACCUACAUGAA	UUCAUGUAGGUGAAGGUGG		[1763-1781]
					19	GAGCUGCCUUAAAAAAAAA	UUUUUUUUUAAGGCAGCUC		[2628-2646]
20	CAGCGAAAUCAACGAGAAA	UUUCUCGUUGAUUUCGCUG		[2167-2185]
					21	CAGCGAACGCACAUCAAGA	UCUUGAUGUGCGUUCGCUG	Ms	[1549-1567]
22	CAAUUAUGGGAGUAAACAA	UUGUUUACUCCCAUAAUUG		[2663-2681]
					23	GGGAGUAAACAAUAGUCUA	UAGACUAUUGUUUACUCCC		[2670-2688]
24	GAGGUAAAAGGCAAGCAAA	UUUGCUUGCCUUUUACCUC		[2836-2854]
					25	CUUCAAUUUCUGUAUAAAA	UUUUAUACAGAAAUUGAAG		[3685-3703]
26	CACCCUAGAUUUGUAUAAA	UUUAUACAAAUCUAGGGUG		[3238-3256]
					27	CCUUCAACCUCCCACACUA	UAGUGUGGGAGGUUGAAGG		[1637-1655]
28	CUGCCUUAAAAAAAAAUAA	UUAUUUUUUUUUAAGGCAG		[2631-2649]
					29	CCUUCAAUUUCUGUAUAAA	UUUAUACAGAAAUUGAAGG		[3684-3702]
30	GAGGAGCUGCCUUAAAAAA	UUUUUUAAGGCAGCUCCUC		[2625-2643]
					31	CUUCCUUAAAGACAUUUAA	UUAAAUGUCUUUAAGGAAG		[2041-2059]
32	UGGUAAGCUUUAUCAUAUA	UAUAUGAUAAAGCUUACCA		[2699-2717]
					33	AAGGCAACUCGUACCCAAA	UUUGGGUACGAGUUGCCUU		[2064-2082]
34	GCCUGUUUGGACUUUGUAA	UUACAAAGUCCAAACAGGC	Ms	[2263-2281]
					35	GCCCACUGACAGACCUUAA	UUAAGGUCUGUCAGUGGGC		[3524-3542]
36	AAGGAGAGGUUUUAAUUAA	UUAAUUAAAACCUCUCCUU		[3036-3054]
					37	GACAGACCUUAAUCUUAAU	AUUAAGAUUAAGGUCUGUC		[3531-3549]
38	GCAGCGAAAUCAACGAGAA	UUCUCGUUGAUUUCGCUGC		[2166-2184]

39	AAUGGAGCAGCGAAAUCAA	UUGAUUUCGCUGCUCCAUU		[2160-2178]
					40	UGUUUUUGUUGAAAACAAA	UUUGUUUUCAACAAAAACA		[3287-3305]
41	GAGCUUUCCUCAAAGGGUA	UACCCUUUGAGGAAAGCUC		[3117-3135]
					42	GAGGUUUUAAUUAAAACAA	UUGUUUUAAUUAAAACCUC		[3041-3059]
43	ACGGCUCCAGCAAGAACAA	UUGUUCUUGCUGGAGCCGU	大鼠，Ms	[659-677]
					44	CGAAGAAAGAGAGGACCAA	UUGGUCCUCUCUUUCUUCG		[1953-1971]
45	UGACAGACCUUAAUCUUAA	UUAAGAUUAAGGUCUGUCA		[3530-3548]
					46	AGAACAAGCCGCACGUCAA	UUGACGUGCGGCUUGUUCU		[671-689]
47	GAGAUGAUCCUAAAAAUAA	UUAUUUUUAGGAUCAUCUC		[1933-1951]
					48	AAGAGAGGACCAACCAGAA	UUCUGGUUGGUCCUCUCUU		[1959-1977]
49	CAGUAGAAUAAAAUCUUAA	UUAAGAUUUUAUUCUACUG		[3646-3664]
					50	UAGCAGUAAUUAAAGAAAA	UUUUCUUUAAUUACUGCUA		[2291-2309]
51	AGCUCUGGAGACUUCUGAA	UUCAGAAGUCUCCAGAGCU		[794-812]
					52	CAAUUUUACCUUCUUUAAA	UUUAAAGAAGGUAAAAUUG		[3087-3105]
53	AGAAACUGGACUUUUUAAA	UUUAAAAAGUCCAGUUUCU		[2181-2199]
					54	GAUGAAAUCUGUUCUGGGA	UCCCAGAACAGAUUUCAUC		[2858-2876]
55	CCAAUUUUACCUUCUUUAA	UUAAAGAAGGUAAAAUUGG		[3086-3104]
					56	CUGUUGUAUUAACAUUUAA	UUAAAUGUUAAUACAACAG		[2535-2553]
57	AAAGGCAACUCGUACCCAA	UUGGGUACGAGUUGCCUUU		[2063-2081]
					58	GCAGUAAUUAAAGAAAAAA	UUUUUUCUUUAAUUACUGC		[2293-2311]
59	AAGCGGAGCUCGAAACUGA	UCAGUUUCGAGCUCCGCUU		[11-29]
					60	CAGUCUUAAGAAAGAGGUA	UACCUCUUUCUUAAGACUG		[2823-2841]
61	AGGAGCUGCCUUAAAAAAA	UUUUUUUAAGGCAGCUCCU		[2626-2644]
					62	AAUCUUAAAGCACUCAUAA	UUAUGAGUGCUUUAAGAUU		[3657-3675]
63	AAGCGUGGAGGAUGAUGGA	UCCAUCAUCCUCCACGCUU		[2213-2231]
					64	AGAUACUUCUGUAACUUAA	UUAAGUUACAGAAGUAUCU		[3720-3738]
65	AGGACCACCCGGAUUACAA	UUGUAAUCCGGGUGGUCCU		[872-890]

66	AAACGGUGCUGCUGGGAAA	UUUCCCAGCAGCACCGUUU		[2756-2774]
					67	AAGGAGGAGCUGCCUUAAA	UUUAAGGCAGCUCCUCCUU		[2622-2640]
68	CUUUGUUGUUUUUGUUGAA	UUCAACAAAAACAACAAAG		[3281-3299]
					69	CCUUUGGGCUGCCUUAUAU	AUAUAAGGCAGCCCAAAGG		[3392-3410]
70	ACGAGAAACUGGACUUUUU	AAAAAGUCCAGUUUCUCGU		[2178-2196]
					71	CCGGAAACUUUUCUUUGCA	UGCAAAGAAAAGUUUCCGG		[70-88]
72	GCCCUAGCUUUUCUUGCAA	UUGCAAGAAAAGCUAGGGC		[2463-2481]
					73	AAAAGCAGAUCUUUUUAAA	UUUAAAAAGAUCUGCUUUU		[3700-3718]
74	GCCGAGAUGAUCCUAAAAA	UUUUUAGGAUCAUCUCGGC		[1930-1948]
					75	AGAGGUAAAAGGCAAGCAA	UUGCUUGCCUUUUACCUCU		[2835-2853]
76	UCCUCACCCUAGAUUUGUA	UACAAAUCUAGGGUGAGGA		[3234-3252]
					77	AGCUCGAAACUGACUGGAA	UUCCAGUCAGUUUCGAGCU		[17-35]
78	AAAUCUUAAAGCACUCAUA	UAUGAGUGCUUUAAGAUUU		[3656-3674]
					79	AAAGCAGAUCUUUUUAAAA	UUUUAAAAAGAUCUGCUUU		[3701-3719]
80	AGACAUUCCACUUGCUAAA	UUUAGCAAGUGGAAUGUCU		[3003-3021]
					81	GAACGCACAUCAAGACGGA	UCCGUCUUGAUGUGCGUUC	Ms	[1553-1571]
82	CCCACUGACAGACCUUAAU	AUUAAGGUCUGUCAGUGGG		[3525-3543]
					83	GCUAAAUGGAGCAGCGAAA	UUUCGCUGCUCCAUUUAGC		[2156-2174]
84	GAUCCUAAAAAUAACCGAA	UUCGGUUAUUUUUAGGAUC		[1938-1956]
					85	AGACCUUUGGGCUGCCUUA	UAAGGCAGCCCAAAGGUCU		[3389-3407]
86	UUGUAUUCCUCACCCUAGA	UCUAGGGUGAGGAAUACAA		[3228-3246]
					87	GGCAAGCAAAGGAGAUGAA	UUCAUCUCCUUUGCUUGCC		[2845-2863]
88	UGUUGGAGCUUUCCUCAAA	UUUGAGGAAAGCUCCAACA		[3112-3130]
					89	CCUUGAGCCUUAAAACGGU	ACCGUUUUAAGGCUCAAGG		[2744-2762]
90	UAAAGACAUUUAAGCUAAA	UUUAGCUUAAAUGUCUUUA		[2047-2065]
					91	CAACCAGAGUAUUUUUGUA	UACAAAAAUACUCUGGUUG	Ms	[2479-2497]
92	AGAUGAUCCUAAAAAUAAC	GUUAUUUUUAGGAUCAUCU		[1934-1952]

93	CCUAAAAAUAACCGAAGAA	UUCUUCGGUUAUUUUUAGG		[1941-1959]
					94	GGAGCAGCGAAAUCAACGA	UCGUUGAUUUCGCUGCUCC		[2163-2181]
95	GGCCUUAUUUUGCAAUUAU	AUAAUUGCAAAAUAAGGCC		[2651-2669]
					96	CGCGUAUGAAUCUCCUGGA	UCCAGGAGAUUCAUACGCG	大鼠，Ms	[368-386]
97	AGAAAGAGGUAAAAGGCAA	UUGCCUUUUACCUCUUUCU		[2831-2849]
					98	CCUGUUGUAUUAACAUUUA	UAAAUGUUAAUACAACAGG		[2534-2552]
99	GCAGAUCUUUUUAAAAAGA	UCUUUUUAAAAAGAUCUGC		[3704-3722]
					100	AAAACACCUUGAGCCUUAA	UUAAGGCUCAAGGUGUUUU	Ms	[2738-2756]
101	CGCUCACAGUACGACUACA	UGUAGUCGUACUGUGAGCG		[1681-1699]
					102	GGCUAAAUGGAGCAGCGAA	UUCGCUGCUCCAUUUAGCC		[2155-2173]
103	CCUCAAAGGGUAUGGUCAU	AUGACCAUACCCUUUGAGG	Ms	[3124-3142]
					104	UCAGAACACCAGCAGUUAA	UUAACUGCUGGUGUUCUGA		[2978-2996]
105	GGGUUAACUUUGCUUAAUU	AAUUAAGCAAAGUUAACCC		[2585-2603]
					106	CAUCCAUAUUUCUCUACAU	AUGUAGAGAAAUAUGGAUG		[3467-3485]
107	UGUUGAAAACAAACUGGAA	UUCCAGUUUGUUUUCAACA		[3293-3311]
					108	GAAGAGAAAAACACCUUGA	UCAAGGUGUUUUUCUCUUC		[2731-2749]
109	AGAGGUUUUAAUUAAAACA	UGUUUUAAUUAAAACCUCU		[3040-3058]
					110	ACCCUAGAUUUGUAUAAAU	AUUUAUACAAAUCUAGGGU		[3239-3257]
111	UCAGUAGAAUAAAAUCUUA	UAAGAUUUUAUUCUACUGA		[3645-3663]
					112	UGAAGAUGACCGACGAGCA	UGCUCGUCGGUCAUCUUCA	大鼠，Ms	[395-413]
113	GUCUUAAGAAAGAGGUAAA	UUUACCUCUUUCUUAAGAC		[2825-2843]
					114	GGAGAAUCGUGUGAUCAGU	ACUGAUCACACGAUUCUCC		[2229-2247]
115	AAAUCAACGAGAAACUGGA	UCCAGUUUCUCGUUGAUUU		[2172-2190]
					116	AGCUUUUCUUGCAACCAGA	UCUGGUUGCAAGAAAAGCU		[2468-2486]
117	CUUUGUAUUCCUCACCCUA	UAGGGUGAGGAAUACAAAG		[3226-3244]
					118	CCUUCAUGAAGAUGACCGA	UCGGUCAUCUUCAUGAAGG	大鼠，Ms	[389-407]
119	AUGAGAGAUUGCAAAUGUA	UACAUUUGCAAUCUCUCAU		[3334-3352]

120	UCACUGCAGUCUUAAGAAA	UUUCUUAAGACUGCAGUGA		[2817-2835]
					121	AAGCAGAUCUUUUUAAAAA	UUUUUAAAAAGAUCUGCUU		[3702-3720]
122	CCUCAGGCUUUGCGAUUUA	UAAAUCGCAAAGCCUGAGG		[2604-2622]
					123	GUGUAUGAUUCAUUACCAU	AUGGUAAUGAAUCAUACAC		[2360-2378]
124	CUCAGGCUUUGCGAUUUAA	UUAAAUCGCAAAGCCUGAG		[2605-2623]
					125	GCUGCCUUAAAAAAAAAUA	UAUUUUUUUUUAAGGCAGC		[2630-2648]
126	CAAUAAAUAUACAUUGCAU	AUGCAAUGUAUAUUUAUUG	Ms	[3907-3925]
					127	CUCGUACCCAAAUUUCCAA	UUGGAAAUUUGGGUACGAG		[2071-2089]
128	ACUUCUGUAACUUAAGAAA	UUUCUUAAGUUACAGAAGU		[3724-3742]
					129	AGGCUUUGCGAUUUAAGGA	UCCUUAAAUCGCAAAGCCU		[2608-2626]
130	GGACCAACCAGAAUUCCCU	AGGGAAUUCUGGUUGGUCC		[1965-1983]
					131	ACAUUGCAUUAAAAAGAAA	UUUCUUUUUAAUGCAAUGU		[3917-3935]
132	CUGUGAGGAAUAUUCUCUA	UAGAGAAUAUUCCUCACAG	Ms	[2317-2335]
					133	ACUGCAGUCUUAAGAAAGA	UCUUUCUUAAGACUGCAGU		[2819-2837]
134	CAUAUUUUGUCUUUAGGUA	UACCUAAAGACAAAAUAUG		[3757-3775]
					135	CUGACAGACCUUAAUCUUA	UAAGAUUAAGGUCUGUCAG		[3529-3547]
136	GGUGCUGCUGGGAAACAUU	AAUGUUUCCCAGCAGCACC		[2760-2778]
					137	ACUCGUACCCAAAUUUCCA	UGGAAAUUUGGGUACGAGU		[2070-2088]
138	GCGACGUCAUCUCCAACAU	AUGUUGGAGAUGACGUCGC	Ms	[1211-1229]
					139	CUUGUUCACUGCAGUCUUA	UAAGACUGCAGUGAACAAG		[2812-2830]
140	UCUUCUUCUUCUUCCUUAA	UUAAGGAAGAAGAAGAAGA		[2031-2049]
					141	AGUUGAACAGUGUGCCCUA	UAGGGCACACUGUUCAACU		[2450-2468]
142	UAAGGAGGAGCUGCCUUAA	UUAAGGCAGCUCCUCCUUA		[2621-2639]
					143	AAAAAUAACCGAAGAAAGA	UCUUUCUUCGGUUAUUUUU		[1944-1962]
144	UCGAGACCUUCGAUGUCAA	UUGACAUCGAAGGUCUCGA		[1229-1247]
					145	CAAUUUCUGUAUAAAAGCA	UGCUUUUAUACAGAAAUUG		[3688-3706]
146	CUGUUCUGGGAAUGUUUCA	UGAAACAUUCCCAGAACAG		[2866-2884]

147	UUGCAAUUAUGGGAGUAAA	UUUACUCCCAUAAUUGCAA		[2660-2678]
					148	AGGCAACUCGUACCCAAAU	AUUUGGGUACGAGUUGCCU		[2065-2083]
149	GGCAACUCGUACCCAAAUU	AAUUUGGGUACGAGUUGCC		[2066-2084]
					150	GUUUUAGAAGUCAGUAGAA	UUCUACUGACUUCUAAAAC	Ms	[3635-3653]
151	UGUGGAUGUCCAAGCAGCA	UGCUGCUUGGACAUCCACA		[1373-1391]
					152	AAGCUAAAGGCAACUCGUA	UACGAGUUGCCUUUAGCUU		[2058-2076]
153	ACCUUUGGGCUGCCUUAUA	UAUAAGGCAGCCCAAAGGU		[3391-3409]
					154	GAGAGGUUUUAAUUAAAAC	GUUUUAAUUAAAACCUCUC		[3039-3057]
155	CAGCUAAACUACUCUUAGU	ACUAAGAGUAGUUUAGCUG		[2434-2452]
					156	CAGCAGUUAACCUUCAAGA	UCUUGAAGGUUAACUGCUG		[2987-3005]
157	AAACUGACUGGAAACUUCA	UGAAGUUUCCAGUCAGUUU		[23-41]
					158	UUGUAAGGAGAGGUUUUAA	UUAAAACCUCUCCUUACAA		[3032-3050]
159	CCAACAUCGAGACCUUCGA	UCGAAGGUCUCGAUGUUGG		[1223-1241]
					160	UACAUUGCAUUAAAAAGAA	UUCUUUUUAAUGCAAUGUA		[3916-3934]
161	AGCCCGAUCUGAAGAAGGA	UCCUUCUUCAGAUCGGGCU		[542-560]
					162	AGGAAUAUUCUCUAUUUUA	UAAAAUAGAGAAUAUUCCU	Ms	[2322-2340]
163	AUGGUCAUCUGUUGUUAAA	UUUAACAACAGAUGACCAU	Ms	[3135-3153]
					164	CUGCCUGUUUGGACUUUGU	ACAAAGUCCAAACAGGCAG	Ms	[2261-2279]
165	ACCAGCAGUUAACCUUCAA	UUGAAGGUUAACUGCUGGU		[2985-3003]
					166	ACUACACCGACCACCAGAA	UUCUGGUGGUCGGUGUAGU		[1694-1712]
167	AGACCUUAAUCUUAAUUAC	GUAAUUAAGAUUAAGGUCU		[3534-3552]
					168	CAACGAGUUUGACCAGUAC	GUACUGGUCAAACUCGUUG		[1245-1263]
169	GGCUAGAGAGUUUGAGGAU	AUCCUCAAACUCUCUAGCC		[3559-3577]
					170	CAGACCUUAAUCUUAAUUA	UAAUUAAGAUUAAGGUCUG		[3533-3551]
171	GAAGUCAGUAGAAUAAAAU	AUUUUAUUCUACUGACUUC		[3641-3659]
					172	UAAGGAGAGGUUUUAAUUA	UAAUUAAAACCUCUCCUUA		[3035-3053]
173	AGAAAAAAGUCCUCUGUGA	UCACAGAGGACUUUUUUCU		[2304-2322]

174	GGAUGAUGGAGAAUCGUGU	ACACGAUUCUCCAUCAUCC		[2222-2240]
					175	UCAUGAAGAUGACCGACGA	UCGUCGGUCAUCUUCAUGA	大鼠，Ms	[392-410]
176	GAGGAAUAUUCUCUAUUUU	AAAAUAGAGAAUAUUCCUC	Ms	[2321-2339]
					177	AAGCAUUUGGUAAGCUUUA	UAAAGCUUACCAAAUGCUU		[2692-2710]
178	GUAAGGAGAGGUUUUAAUU	AAUUAAAACCUCUCCUUAC		[3034-3052]
					179	GGUAAGCUUUAUCAUAUAU	AUAUAUGAUAAAGCUUACC		[2700-2718]
180	UCUGGAGACUUCUGAACGA	UCGUUCAGAAGUCUCCAGA		[797-815]
					181	AAACACCUUGAGCCUUAAA	UUUAAGGCUCAAGGUGUUU	Ms	[2739-2757]
182	CUUAAAGCACUCAUAAUAU	AUAUUAUGAGUGCUUUAAG		[3660-3678]
					183	CAAGCAAAGGAGAUGAAAU	AUUUCAUCUCCUUUGCUUG		[2847-2865]
184	GCAAGCAAAGGAGAUGAAA	UUUCAUCUCCUUUGCUUGC		[2846-2864]
					185	ACGUGUGGAUGUCCAAGCA	UGCUUGGACAUCCACACGU		[1370-1388]
186	AGAAUAAAAUCUUAAAGCA	UGCUUUAAGAUUUUAUUCU		[3650-3668]
					187	GUUUGGACUUUGUAAUUAU	AUAAUUACAAAGUCCAAAC	Ms	[2267-2285]
188	CACCAGCAGUUAACCUUCA	UGAAGGUUAACUGCUGGUG		[2984-3002]
					189	GGAGCUUUCCUCAAAGGGU	ACCCUUUGAGGAAAGCUCC		[3116-3134]
190	UCUUCUUCUUCCUUAAAGA	UCUUUAAGGAAGAAGAAGA		[2034-2052]
					191	GGGAUUUAUACAUAUUUUU	AAAAAUAUGUAUAAAUCCC		[2385-2403]
192	AACACCUUGAGCCUUAAAA	UUUUAAGGCUCAAGGUGUU		[2740-2758]
					193	CUAAAAAUAACCGAAGAAA	UUUCUUCGGUUAUUUUUAG		[1942-1960]
194	UAUUUUGUCUUUAGGUAAA	UUUACCUAAAGACAAAAUA		[3759-3777]
					195	ACUUGUUUCUUUUUUUGUA	UACAAAAAAAGAAACAAGU		[3312-3330]
196	CAGUAAUUAAAGAAAAAAG	CUUUUUUCUUUAAUUACUG		[2294-2312]
					197	UCCUUCAAUUUCUGUAUAA	UUAUACAGAAAUUGAAGGA		[3683-3701]
198	AAGACAUUCCACUUGCUAA	UUAGCAAGUGGAAUGUCUU		[3002-3020]
					199	CAAAGGAGAUGAAAUCUGU	ACAGAUUUCAUCUCCUUUG		[2851-2869]
200	CAUUCCACUUGCUAAAAUU	AAUUUUAGCAAGUGGAAUG		[3006-3024]

201	ACGUCAUCUCCAACAUCGA	UCGAUGUUGGAGAUGACGU		[1214-1232]
					202	UCGUGUUUUGUUUGUUUCA	UGAAACAAACAAAACACGA		[3793-3811]
203	UCUUAAAGCACUCAUAAUA	UAUUAUGAGUGCUUUAAGA		[3659-3677]
					204	CUAGAGAAGCAUUUGGUAA	UUACCAAAUGCUUCUCUAG		[2686-2704]
205	GGAGGAUGAUGGAGAAUCG	CGAUUCUCCAUCAUCCUCC		[2219-2237]
					206	GACCUAUCCAAGCGCAUUA	UAAUGCGCUUGGAUAGGUC		[2101-2119]
207	GGUCAUCUGUUGUUAAAUU	AAUUUAACAACAGAUGACC	Ms	[3137-3155]
					208	UGCCCUAGCUUUUCUUGCA	UGCAAGAAAAGCUAGGGCA		[2462-2480]
209	ACAUUUAAGCUAAAGGCAA	UUGCCUUUAGCUUAAAUGU		[2052-2070]
					210	GUAAGCUUUAUCAUAUAUA	UAUAUAUGAUAAAGCUUAC		[2701-2719]
211	ACUCCACCUUCACCUACAU	AUGUAGGUGAAGGUGGAGU		[1760-1778]
					212	CAGGCUUUGCGAUUUAAGG	CCUUAAAUCGCAAAGCCUG		[2607-2625]
213	AAACAUUUGCACUCUUUUA	UAAAAGAGUGCAAAUGUUU		[2772-2790]
					214	CCUCACCCUAGAUUUGUAU	AUACAAAUCUAGGGUGAGG		[3235-3253]
215	GAAACUUGUUUCUUUUUUU	AAAAAAAGAAACAAGUUUC		[3309-3327]
					216	UUCACUGCAGUCUUAAGAA	UUCUUAAGACUGCAGUGAA		[2816-2834]
217	GAUACUUCUGUAACUUAAG	CUUAAGUUACAGAAGUAUC		[3721-3739]
					218	GAUUGCAAAUGUAGUGUAU	AUACACUACAUUUGCAAUC		[3340-3358]
219	GCCUUUUUGUCCAUCCCUU	AAGGGAUGGACAAAAAGGC		[3258-3276]
					220	CUGGAAACUUGUUUCUUUU	AAAAGAAACAAGUUUCCAG		[3306-3324]
221	UGUAAGGAGAGGUUUUAAU	AUUAAAACCUCUCCUUACA		[3033-3051]
					222	UCUUAAGAAAGAGGUAAAA	UUUUACCUCUUUCUUAAGA		[2826-2844]
223	UAAACAAUAGUCUAGAGAA	UUCUCUAGACUAUUGUUUA		[2675-2693]
					224	CCAUAUUUCUCUACAUCUU	AAGAUGUAGAGAAAUAUGG		[3470-3488]
225	UAGAAGUCAGUAGAAUAAA	UUUAUUCUACUGACUUCUA	Ms	[3639-3657]
					226	UAUGGUCAUCUGUUGUUAA	UUAACAACAGAUGACCAUA	Ms	[3134-3152]
227	UAUUUUUCCAACAGCUAAA	UUUAGCUGUUGGAAAAAUA		[2423-2441]

228	CAUCCUUCAAUUUCUGUAU	AUACAGAAAUUGAAGGAUG		[3681-3699]
					229	UCACCCUAGAUUUGUAUAA	UUAUACAAAUCUAGGGUGA		[3237-3255]
230	GCAUCCUUCAAUUUCUGUA	UACAGAAAUUGAAGGAUGC		[3680-3698]
					231	GGGAAACAUUUGCACUCUU	AAGAGUGCAAAUGUUUCCC		[2769-2787]
232	AGAGAGGACCAACCAGAAU	AUUCUGGUUGGUCCUCUCU		[1960-1978]
					233	CACUUGCUAAAAUUAUUUA	UAAAUAAUUUUAGCAAGUG		[3011-3029]
234	CUCAGAACACCAGCAGUUA	UAACUGCUGGUGUUCUGAG		[2977-2995]
					235	UGGAGACUUCUGAACGAGA	UCUCGUUCAGAAGUCUCCA		[799-817]
236	ACAGCUCACUCGACCUUGA	UCAAGGUCGAGUGAGCUGU		[1884-1902]
					237	CCUGUUUGGACUUUGUAAU	AUUACAAAGUCCAAACAGG	Ms	[2264-2282]
238	CUUUUGUUCUCUCCGUGAA	UUCACGGAGAGAACAAAAG		[3836-3854]
					239	CAGUUAACCUUCAAGACAU	AUGUCUUGAAGGUUAACUG		[2990-3008]
240	AAAGCAAGUUUCUUUGUAU	AUACAAAGAAACUUGCUUU		[3215-3233]
					241	UCCUAAAAAUAACCGAAGA	UCUUCGGUUAUUUUUAGGA		[1940-1958]
242	GUUGAAAACAAACUGGAAA	UUUCCAGUUUGUUUUCAAC		[3294-3312]
					243	CAGAUCUUUUUAAAAAGAU	AUCUUUUUAAAAAGAUCUG		[3705-3723]
244	UCACCUGUGCCUCUCAGAA	UUCUGAGAGGCACAGGUGA		[2965-2983]
					245	UGCCUGUUUGGACUUUGUA	UACAAAGUCCAAACAGGCA	Ms	[2262-2280]
246	CCUUUUUGUCCAUCCCUUU	AAAGGGAUGGACAAAAAGG		[3259-3277]
					247	AGAGUAUUUUUGUACAGAU	AUCUGUACAAAAAUACUCU	Ms	[2484-2502]
248	UAAACUACUCUUAGUUGAA	UUCAACUAAGAGUAGUUUA		[2438-2456]
					249	GAAACUUUUCUUUGCAGGA	UCCUGCAAAGAAAAGUUUC		[73-91]
250	UCGUGUGAUCAGUGUGCUA	UAGCACACUGAUCACACGA		[2235-2253]
					251	GACCUUUGGGCUGCCUUAU	AUAAGGCAGCCCAAAGGUC		[3390-3408]
252	GACCAACCAGAAUUCCCUU	AAGGGAAUUCUGGUUGGUC		[1966-1984]
					253	ACCUGUGCCUCUCAGAACA	UGUUCUGAGAGGCACAGGU		[2967-2985]
254	UCCACUUGCUAAAAUUAUU	AAUAAUUUUAGCAAGUGGA		[3009-3027]

255	UUUCUUUGCAGGAGGAGAA	UUCUCCUCCUGCAAAGAAA		[79-97]
					256	UGUCCAUCCCUUUUUUCUU	AAGAAAAAAGGGAUGGACA		[3265-3283]
257	GACCUUAAUCUUAAUUACU	AGUAAUUAAGAUUAAGGUC		[3535-3553]
					258	CUUCUUCUUCUUCCUUAAA	UUUAAGGAAGAAGAAGAAG		[2032-2050]
259	GCGAAAUCAACGAGAAACU	AGUUUCUCGUUGAUUUCGC		[2169-2187]
					260	GGACUUUUUAAACCCUCUU	AAGAGGGUUUAAAAAGUCC		[2188-2206]
261	CGGAAACUUUUCUUUGCAG	CUGCAAAGAAAAGUUUCCG		[71-89]
					262	GAGUAAACAAUAGUCUAGA	UCUAGACUAUUGUUUACUC		[2672-2690]
263	UUUGGUAAGCUUUAUCAUA	UAUGAUAAAGCUUACCAAA		[2697-2715]
					264	CGUGUGAUCAGUGUGCUAA	UUAGCACACUGAUCACACG		[2236-2254]
265	AUCUUAAAGCACUCAUAAU	AUUAUGAGUGCUUUAAGAU		[3658-3676]
					266	GUUGGAGCUUUCCUCAAAG	CUUUGAGGAAAGCUCCAAC		[3113-3131]
267	GAGAGAUUGCAAAUGUAGU	ACUACAUUUGCAAUCUCUC		[3336-3354]
					268	UUGUUUUUGUUGAAAACAA	UUGUUUUCAACAAAAACAA		[3286-3304]
269	CUCAAAGGCUACGACUGGA	UCCAGUCGUAGCCUUUGAG		[613-631]
					270	CAAGUUUCUUUGUAUUCCU	AGGAAUACAAAGAAACUUG		[3219-3237]
271	CAUUUGGUAAGCUUUAUCA	UGAUAAAGCUUACCAAAUG		[2695-2713]
					272	UGAUCAGUGUGCUAAAUCU	AGAUUUAGCACACUGAUCA		[2240-2258]
273	CUUUGCGAUUUAAGGAGGA	UCCUCCUUAAAUCGCAAAG		[2611-2629]
					274	GAGUAUUUUUGUACAGAUU	AAUCUGUACAAAAAUACUC	Ms	[2485-2503]
275	CAAUAAGUGCCCGAGCACA	UGUGCUCGGGCACUUAUUG		[2890-2908]
					276	AACUCCAGCUCCUACUACA	UGUAGUAGGAGCUGGAGUU		[1711-1729]
277	AAAAGUCCUCUGUGAGGAA	UUCCUCACAGAGGACUUUU	Ms	[2308-2326]
					278	UUAGCAGUAAUUAAAGAAA	UUUCUUUAAUUACUGCUAA		[2290-2308]
279	GCAAUUAUGGGAGUAAACA	UGUUUACUCCCAUAAUUGC		[2662-2680]
					280	GAAACUGGACUUUUUAAAC	GUUUAAAAAGUCCAGUUUC		[2182-2200]
281	UUGCAGGAGGAGAAGAGAA	UUCUCUUCUCCUCCUGCAA		[84-102]

282	CACAGUACGACUACACCGA	UCGGUGUAGUCGUACUGUG		[1685-1703]
					283	GCAACUCGUACCCAAAUUU	AAAUUUGGGUACGAGUUGC		[2067-2085]
284	GAUUCAUUACCAUUUUGAG	CUCAAAAUGGUAAUGAAUC		[2366-2384]
					285	GUCUUUAGGUAAAAGCUUU	AAAGCUUUUACCUAAAGAC		[3765-3783]
286	GAGAGUUUGAGGAUUGCUU	AAGCAAUCCUCAAACUCUC		[3564-3582]
					287	UUAGAAGUCAGUAGAAUAA	UUAUUCUACUGACUUCUAA	Ms	[3638-3656]
288	UGAAAUCUGUUCUGGGAAU	AUUCCCAGAACAGAUUUCA		[2860-2878]
					289	GGAGACUUCUGAACGAGAG	CUCUCGUUCAGAAGUCUCC		[800-818]
290	GCCUUAUUUUGCAAUUAUG	CAUAAUUGCAAAAUAAGGC		[2652-2670]
					291	AAGAAAGAGGUAAAAGGCA	UGCCUUUUACCUCUUUCUU		[2830-2848]
292	UGAGGAAUAUUCUCUAUUU	AAAUAGAGAAUAUUCCUCA	Ms	[2320-2338]
					293	GUUGUUAAAUUAUGUUCUU	AAGAACAUAAUUUAACAAC	Ms	[3145-3163]
294	GUUCGUGUUUUGUUUGUUU	AAACAAACAAAACACGAAC		[3791-3809]
					295	UAUAAAUGAGAGAUUGCAA	UUGCAAUCUCUCAUUUAUA		[3329-3347]
296	AUACUUCUGUAACUUAAGA	UCUUAAGUUACAGAAGUAU		[3722-3740]
					297	CCGAAGAAAGAGAGGACCA	UGGUCCUCUCUUUCUUCGG		[1952-1970]
298	UUUAAAGAAGAGAAAAACA	UGUUUUUCUCUUCUUUAAA		[2725-2743]
					299	AGCUUUCCUCAAAGGGUAU	AUACCCUUUGAGGAAAGCU		[3118-3136]
300	CUUCUGAACGAGAGCGAGA	UCUCGCUCUCGUUCAGAAG		[805-823]
					301	AAUUAUGUUCUUAACUGUA	UACAGUUAAGAACAUAAUU	Ms	[3152-3170]
302	UCUAGAGAAGCAUUUGGUA	UACCAAAUGCUUCUCUAGA		[2685-2703]
					303	AGAAGGACCACCCGGAUUA	UAAUCCGGGUGGUCCUUCU		[869-887]
304	CACUUUUGCUCUUUUUCCU	AGGAAAAAGAGCAAAAGUG		[119-137]
					305	AUAUUUUGUCUUUAGGUAA	UUACCUAAAGACAAAAUAU		[3758-3776]
306	UUAAAAAGAUACUUCUGUA	UACAGAAGUAUCUUUUUAA		[3714-3732]
					307	UGCUCUUAUUUUUCCAACA	UGUUGGAAAAAUAAGAGCA	Ms	[2417-2435]
308	GAGUUUGAGGAUUGCUUUU	AAAAGCAAUCCUCAAACUC		[3566-3584]

309	GCCUUAAAACGGUGCUGCU	AGCAGCACCGUUUUAAGGC		[2750-2768]
					310	CCACUUGCUAAAAUUAUUU	AAAUAAUUUUAGCAAGUGG		[3010-3028]
311	AGACCUUCGAUGUCAACGA	UCGUUGACAUCGAAGGUCU		[1232-1250]
					312	UGGGAACAACCCGUCUACA	UGUAGACGGGUUGUUCCCA		[1864-1882]
313	GCAUUUAAAUCAUAUUUUG	CAAAAUAUGAUUUAAAUGC		[3747-3765]
					314	AUUAUGUUCUUAACUGUAA	UUACAGUUAAGAACAUAAU	Ms	[3153-3171]
315	GUCAUCUGUUGUUAAAUUA	UAAUUUAACAACAGAUGAC	Ms	[3138-3156]
					316	AGAAAGAGAGGACCAACCA	UGGUUGGUCCUCUCUUUCU		[1956-1974]
317	UAUCCAAGCGCAUUACCCA	UGGGUAAUGCGCUUGGAUA		[2105-2123]
					318	AACUUUGCUUAAUUCCUCA	UGAGGAAUUAAGCAAAGUU		[2590-2608]
319	GCUUGUUCACUGCAGUCUU	AAGACUGCAGUGAACAAGC		[2811-2829]
					320	CACUGACAGACCUUAAUCU	AGAUUAAGGUCUGUCAGUG		[3527-3545]
321	GAAGCAUUUGGUAAGCUUU	AAAGCUUACCAAAUGCUUC		[2691-2709]
					322	AAACAAACUGGAAACUUGU	ACAAGUUUCCAGUUUGUUU		[3299-3317]
323	UGUGCCUCUCAGAACACCA	UGGUGUUCUGAGAGGCACA		[2970-2988]
					324	UCAACGGCUCCAGCAAGAA	UUCUUGCUGGAGCCGUUGA	大鼠，Ms	[656-674]
325	GGACUUUGUAAUUAUUUUU	AAAAAUAAUUACAAAGUCC	Ms	[2271-2289]
					326	ACACCUUGAGCCUUAAAAC	GUUUUAAGGCUCAAGGUGU		[2741-2759]
327	CGAAACUGACUGGAAACUU	AAGUUUCCAGUCAGUUUCG		[21-39]
					328	GUUCACUGCAGUCUUAAGA	UCUUAAGACUGCAGUGAAC		[2815-2833]
329	GACAUUUAAGCUAAAGGCA	UGCCUUUAGCUUAAAUGUC		[2051-2069]
					330	UCAACGAGUUUGACCAGUA	UACUGGUCAAACUCGUUGA		[1244-1262]
331	CAAGACAUUCCACUUGCUA	UAGCAAGUGGAAUGUCUUG		[3001-3019]
					332	CAAAAACAAUGCAAGCAUG	CAUGCUUGCAUUGUUUUUG		[3445-3463]
333	GGGUAUGGUCAUCUGUUGU	ACAACAGAUGACCAUACCC	Ms	[3131-3149]
					334	GUCAGUAGAAUAAAAUCUU	AAGAUUUUAUUCUACUGAC		[3644-3662]
335	AAAUGUAGUGUAUCACUGA	UCAGUGAUACACUACAUUU		[3346-3364]

336	AGCAGAUCUUUUUAAAAAG	CUUUUUAAAAAGAUCUGCU		[3703-3721]
					337	CAGAGUAUUUUUGUACAGA	UCUGUACAAAAAUACUCUG	Ms	[2483-2501]
338	UGUCAUCCAUAUUUCUCUA	UAGAGAAAUAUGGAUGACA		[3464-3482]
					339	CCAUGAACGCCUUCAUGGU	ACCAUGAAGGCGUUCAUGG	大鼠，Ms	[695-713]
340	AGGUAAAAGGCAAGCAAAG	CUUUGCUUGCCUUUUACCU		[2837-2855]
					341	CCACCCGGAUUACAAGUAC	GUACUUGUAAUCCGGGUGG		[876-894]
342	AACGGCUCCAGCAAGAACA	UGUUCUUGCUGGAGCCGUU	大鼠，Ms	[658-676]
					343	GACAUUCCACUUGCUAAAA	UUUUAGCAAGUGGAAUGUC		[3004-3022]
344	ACAGAUUUGCUUUCUCUUA	UAAGAGAAAGCAAAUCUGU		[2497-2515]
					345	GUGUUUUGUUUGUUUCACU	AGUGAAACAAACAAAACAC		[3795-3813]
346	GUAUGGUCAUCUGUUGUUA	UAACAACAGAUGACCAUAC	Ms	[3133-3151]
					347	CCCUUUUUUCUUUGUUGUU	AACAACAAAGAAAAAAGGG		[3272-3290]
348	AGGCCUUAUUUUGCAAUUA	UAAUUGCAAAAUAAGGCCU		[2650-2668]
					349	GUAUAAAAGCAGAUCUUUU	AAAAGAUCUGCUUUUAUAC		[3696-3714]
350	GAACAGUGUGCCCUAGCUU	AAGCUAGGGCACACUGUUC		[2454-2472]
					351	UGGACUUUGUAAUUAUUUU	AAAAUAAUUACAAAGUCCA	Ms	[2270-2288]
352	AGCAUUUGGUAAGCUUUAU	AUAAAGCUUACCAAAUGCU		[2693-2711]
					353	AAUUAUGGGAGUAAACAAU	AUUGUUUACUCCCAUAAUU		[2664-2682]
354	UUUUGUUCUCUCCGUGAAA	UUUCACGGAGAGAACAAAA		[3837-3855]
					355	GUAGUGUAUCACUGAGUCA	UGACUCAGUGAUACACUAC		[3350-3368]
356	AUUUUGUCUUUAGGUAAAA	UUUUACCUAAAGACAAAAU		[3760-3778]
					357	GAAACUGACUGGAAACUUC	GAAGUUUCCAGUCAGUUUC		[22-40]
358	GAGAGGACCAACCAGAAUU	AAUUCUGGUUGGUCCUCUC		[1961-1979]
					359	CUUAUUUUUCCAACAGCUA	UAGCUGUUGGAAAAAUAAG		[2421-2439]
360	CGUACCCAAAUUUCCAAGA	UCUUGGAAAUUUGGGUACG		[2073-2091]
					361	AUAAAUGAGAGAUUGCAAA	UUUGCAAUCUCUCAUUUAU		[3330-3348]
362	UAAAAAGAUACUUCUGUAA	UUACAGAAGUAUCUUUUUA		[3715-3733]

363	AAAGAGAGGACCAACCAGA	UCUGGUUGGUCCUCUCUUU		[1958-1976]
					364	AGAGUUUGAGGAUUGCUUU	AAAGCAAUCCUCAAACUCU		[3565-3583]
365	CUCGAAACUGACUGGAAAC	GUUUCCAGUCAGUUUCGAG		[19-37]
					366	ACCCGGAUUACAAGUACCA	UGGUACUUGUAAUCCGGGU		[878-896]
367	CCUUCGAUGUCAACGAGUU	AACUCGUUGACAUCGAAGG		[1235-1253]
					368	UGUGAUCAGUGUGCUAAAU	AUUUAGCACACUGAUCACA		[2238-2256]
369	UUCUGAACGAGAGCGAGAA	UUCUCGCUCUCGUUCAGAA		[806-824]
					370	GCCUUAAAAAAAAAUAAAG	CUUUAUUUUUUUUUAAGGC		[2633-2651]
371	CUUGUUUCUUUUUUUGUAU	AUACAAAAAAAGAAACAAG		[3313-3331]
					372	CAACGAGAAACUGGACUUU	AAAGUCCAGUUUCUCGUUG		[2176-2194]
373	AUGAAAUCUGUUCUGGGAA	UUCCCAGAACAGAUUUCAU		[2859-2877]
					374	UGUAUUCCUCACCCUAGAU	AUCUAGGGUGAGGAAUACA		[3229-3247]
375	CUCACCCUAGAUUUGUAUA	UAUACAAAUCUAGGGUGAG		[3236-3254]
					376	GAAACAUUUGCACUCUUUU	AAAAGAGUGCAAAUGUUUC		[2771-2789]
377	UUGGUAAGCUUUAUCAUAU	AUAUGAUAAAGCUUACCAA		[2698-2716]
					378	AAAAGAUACUUCUGUAACU	AGUUACAGAAGUAUCUUUU		[3717-3735]
379	ACCAGAACUCCAGCUCCUA	UAGGAGCUGGAGUUCUGGU		[1706-1724]
					380	GAUGGAGAAUCGUGUGAUC	GAUCACACGAUUCUCCAUC		[2226-2244]
381	GCUUAAUUCCUCAGGCUUU	AAAGCCUGAGGAAUUAAGC		[2596-2614]
					382	ACUGGAAACUUGUUUCUUU	AAAGAAACAAGUUUCCAGU		[3305-3323]
383	AAAUUAUGUUCUUAACUGU	ACAGUUAAGAACAUAAUUU	Ms	[3151-3169]
					384	UACCCAAAUUUCCAAGACA	UGUCUUGGAAAUUUGGGUA		[2075-2093]
385	GAGGAAGUCGGUGAAGAAC	GUUCUUCACCGACUUCCUC	Ms	[906-924]
					386	CUAAACUACUCUUAGUUGA	UCAACUAAGAGUAGUUUAG		[2437-2455]
387	UUAUUUUUCCAACAGCUAA	UUAGCUGUUGGAAAAAUAA		[2422-2440]
					388	GACUUCUGAACGAGAGCGA	UCGCUCUCGUUCAGAAGUC		[803-821]
389	GGAAACAUUUGCACUCUUU	AAAGAGUGCAAAUGUUUCC		[2770-2788]

390	CUGUAUAAAAGCAGAUCUU	AAGAUCUGCUUUUAUACAG		[3694-3712]
					391	CCCGAUCUGAAGAAGGAGA	UCUCCUUCUUCAGAUCGGG		[544-562]
392	CCCUAGAUUUGUAUAAAUG	CAUUUAUACAAAUCUAGGG		[3240-3258]
					393	CCUCUGUGAGGAAUAUUCU	AGAAUAUUCCUCACAGAGG	Ms	[2314-2332]
394	CUUCGAUGUCAACGAGUUU	AAACUCGUUGACAUCGAAG		[1236-1254]
					395	AGAACUCCAGCUCCUACUA	UAGUAGGAGCUGGAGUUCU		[1709-1727]
396	CCGUGAAACUUACCUUUCC	GGAAAGGUAAGUUUCACGG		[3848-3866]
					397	ACCAGAGUAUUUUUGUACA	UGUACAAAAAUACUCUGGU	Ms	[2481-2499]
398	AGUCCUCUGUGAGGAAUAU	AUAUUCCUCACAGAGGACU	Ms	[2311-2329]
					399	CCAAGCGCAUUACCCACUU	AAGUGGGUAAUGCGCUUGG		[2108-2126]
400	CAACAUCGAGACCUUCGAU	AUCGAAGGUCUCGAUGUUG		[1224-1242]
					401	AAGGGUAUGGUCAUCUGUU	AACAGAUGACCAUACCCUU	Ms	[3129-3147]
402	AAAGGAGAUGAAAUCUGUU	AACAGAUUUCAUCUCCUUU		[2852-2870]
					403	AGCUGCCUUAAAAAAAAAU	AUUUUUUUUUAAGGCAGCU		[2629-2647]
404	ACAAUAGUCUAGAGAAGCA	UGCUUCUCUAGACUAUUGU		[2678-2696]
					405	GUCCAUCCCUUUUUUCUUU	AAAGAAAAAAGGGAUGGAC		[3266-3284]
406	AAGAGAAAAACACCUUGAG	CUCAAGGUGUUUUUCUCUU		[2732-2750]
					407	AAAAACACCUUGAGCCUUA	UAAGGCUCAAGGUGUUUUU		[2737-2755]
408	UGAACAGUGUGCCCUAGCU	AGCUAGGGCACACUGUUCA		[2453-2471]
					409	CGUGAAACUUACCUUUCCC	GGGAAAGGUAAGUUUCACG		[3849-3867]
410	AUCUGUUCUGGGAAUGUUU	AAACAUUCCCAGAACAGAU		[2864-2882]
					411	AGAUAAAAUUAAAUGCUCU	AGAGCAUUUAAUUUUAUCU		[2404-2422]
412	CAUUUAAGCUAAAGGCAAC	GUUGCCUUUAGCUUAAAUG		[2053-2071]
					413	CACAAACAUGACCUAUCCA	UGGAUAGGUCAUGUUUGUG		[2092-2110]
414	UCUUCUUCCUUAAAGACAU	AUGUCUUUAAGGAAGAAGA		[2037-2055]
					415	UGCAGCACAAGAAGGACCA	UGGUCCUUCUUGUGCUGCA		[860-878]
416	AGUGUAUCACUGAGUCAUU	AAUGACUCAGUGAUACACU		[3352-3370]

417	CGAUGUCAACGAGUUUGAC	GUCAAACUCGUUGACAUCG		[1239-1257]
					418	GUAAAAGGCAAGCAAAGGA	UCCUUUGCUUGCCUUUUAC		[2839-2857]
419	CUCUCAGAACACCAGCAGU	ACUGCUGGUGUUCUGAGAG		[2975-2993]
					420	UGAUCCUAAAAAUAACCGA	UCGGUUAUUUUUAGGAUCA		[1937-1955]
421	UUGUUGUUUUUGUUGAAAA	UUUUCAACAAAAACAACAA		[3283-3301]
					422	CCUUUUGUUCUCUCCGUGA	UCACGGAGAGAACAAAAGG		[3835-3853]
423	CUUCAACCUCCCACACUAC	GUAGUGUGGGAGGUUGAAG		[1638-1656]
					424	CAGUGUGCUAAAUCUCUCU	AGAGAGAUUUAGCACACUG		[2244-2262]
425	GAUAAAAUUAAAUGCUCUU	AAGAGCAUUUAAUUUUAUC		[2405-2423]
					426	UGGUCAUCUGUUGUUAAAU	AUUUAACAACAGAUGACCA	Ms	[3136-3154]
427	GUUCUCUCCGUGAAACUUA	UAAGUUUCACGGAGAGAAC		[3841-3859]
					428	CUUUUUUCUUUGUUGUUUU	AAAACAACAAAGAAAAAAG		[3274-3292]
429	UAAAAGCAGAUCUUUUUAA	UUAAAAAGAUCUGCUUUUA		[3699-3717]
					430	UACUUCUGUAACUUAAGAA	UUCUUAAGUUACAGAAGUA		[3723-3741]
431	AACUGACUGGAAACUUCAG	CUGAAGUUUCCAGUCAGUU		[24-42]
					432	GGCAUUUAAAUCAUAUUUU	AAAAUAUGAUUUAAAUGCC		[3746-3764]
433	GAGUCAUUUGCAGUGUUUU	AAAACACUGCAAAUGACUC		[3363-3381]
					434	GGUAAAAGCUUUGGUUUGU	ACAAACCAAAGCUUUUACC		[3772-3790]
435	AAAUAACCGAAGAAAGAGA	UCUCUUUCUUCGGUUAUUU		[1946-1964]
					436	AAAAAAUAAAGGCCUUAUU	AAUAAGGCCUUUAUUUUUU		[2641-2659]
437	UUUAGAAGUCAGUAGAAUA	UAUUCUACUGACUUCUAAA	Ms	[3637-3655]
					438	AUCUGAAGAAGGAGAGCGA	UCGCUCUCCUUCUUCAGAU	大鼠	[548-566]
439	AUCCUUCAAUUUCUGUAUA	UAUACAGAAAUUGAAGGAU		[3682-3700]
					440	AUUUGGUAAGCUUUAUCAU	AUGAUAAAGCUUACCAAAU		[2696-2714]
441	CCUUAAAGACAUUUAAGCU	AGCUUAAAUGUCUUUAAGG		[2044-2062]
					442	UUUUGUCCAUCCCUUUUUU	AAAAAAGGGAUGGACAAAA		[3262-3280]
443	GAAAGAGAGGACCAACCAG	CUGGUUGGUCCUCUCUUUC		[1957-1975]

444	GUGUGCCCUAGCUUUUCUU	AAGAAAAGCUAGGGCACAC		[2459-2477]
					445	CAAAGGGUAUGGUCAUCUG	CAGAUGACCAUACCCUUUG	Ms	[3127-3145]
446	UCCUCAAAGGGUAUGGUCA	UGACCAUACCCUUUGAGGA	Ms	[3123-3141]
					447	GGAGUAAACAAUAGUCUAG	CUAGACUAUUGUUUACUCC		[2671-2689]
448	UUUUAGCAGUAAUUAAAGA	UCUUUAAUUACUGCUAAAA		[2288-2306]
					449	CAAACAUGACCUAUCCAAG	CUUGGAUAGGUCAUGUUUG		[2094-2112]
450	UUGCAAAUGUAGUGUAUCA	UGAUACACUACAUUUGCAA		[3342-3360]
					451	CUGUUUGGACUUUGUAAUU	AAUUACAAAGUCCAAACAG	Ms	[2265-2283]
452	AGAAAAACACCUUGAGCCU	AGGCUCAAGGUGUUUUUCU		[2735-2753]
					453	UGUGAGGAAUAUUCUCUAU	AUAGAGAAUAUUCCUCACA	Ms	[2318-2336]
454	ACUUUUCUUUGCAGGAGGA	UCCUCCUGCAAAGAAAAGU		[76-94]
					455	GUUGUUGGAGCUUUCCUCA	UGAGGAAAGCUCCAACAAC		[3110-3128]
456	AAAAGCAAGUUUCUUUGUA	UACAAAGAAACUUGCUUUU		[3214-3232]
					457	AAAUGCUCUUAUUUUUCCA	UGGAAAAAUAAGAGCAUUU	Ms	[2414-2432]
458	UUGUUGGAGCUUUCCUCAA	UUGAGGAAAGCUCCAACAA		[3111-3129]
					459	UGGACUUUUUAAACCCUCU	AGAGGGUUUAAAAAGUCCA		[2187-2205]
460	AGCCCACUGACAGACCUUA	UAAGGUCUGUCAGUGGGCU		[3523-3541]
					461	CGUCAUCUCCAACAUCGAG	CUCGAUGUUGGAGAUGACG		[1215-1233]
462	UCAUCUGUUGUUAAAUUAU	AUAAUUUAACAACAGAUGA	Ms	[3139-3157]
					463	GAAAGAGGUAAAAGGCAAG	CUUGCCUUUUACCUCUUUC		[2832-2850]
464	UAAAGGCCUUAUUUUGCAA	UUGCAAAAUAAGGCCUUUA		[2647-2665]
					465	GCUAGAGAGUUUGAGGAUU	AAUCCUCAAACUCUCUAGC		[3560-3578]
466	AAGAUACUUCUGUAACUUA	UAAGUUACAGAAGUAUCUU		[3719-3737]
					467	AGUCUUAAGAAAGAGGUAA	UUACCUCUUUCUUAAGACU		[2824-2842]
468	CUUCUUCCUUAAAGACAUU	AAUGUCUUUAAGGAAGAAG		[2038-2056]
					469	CAUGAAGAUGACCGACGAG	CUCGUCGGUCAUCUUCAUG	大鼠，Ms	[393-411]
470	UGUCUUUAGGUAAAAGCUU	AAGCUUUUACCUAAAGACA		[3764-3782]

471	GUAUAAAUGAGAGAUUGCA	UGCAAUCUCUCAUUUAUAC		[3328-3346]
					472	AUAAAAGCAGAUCUUUUUA	UAAAAAGAUCUGCUUUUAU		[3698-3716]
473	AUUCCACUUGCUAAAAUUA	UAAUUUUAGCAAGUGGAAU		[3007-3025]
					474	AAGCAAGUUUCUUUGUAUU	AAUACAAAGAAACUUGCUU		[3216-3234]
475	AAAACGGUGCUGCUGGGAA	UUCCCAGCAGCACCGUUUU		[2755-2773]
					476	UAUUUAUUUUGUAAGGAGA	UCUCCUUACAAAAUAAAUA	Ms	[3024-3042]
477	AGUUAACCUUCAAGACAUU	AAUGUCUUGAAGGUUAACU		[2991-3009]
					478	AACUACUCUUAGUUGAACA	UGUUCAACUAAGAGUAGUU		[2440-2458]
479	AAGCUCUGGAGACUUCUGA	UCAGAAGUCUCCAGAGCUU		[793-811]
					480	CUGCUGGGAAACAUUUGCA	UGCAAAUGUUUCCCAGCAG		[2764-2782]
481	GGAAACUUGUUUCUUUUUU	AAAAAAGAAACAAGUUUCC		[3308-3326]
					482	AUUAUGGGAGUAAACAAUA	UAUUGUUUACUCCCAUAAU		[2665-2683]
483	UUCUGGGAAUGUUUCAGCA	UGCUGAAACAUUCCCAGAA		[2869-2887]
					484	UUAAAGACAUUUAAGCUAA	UUAGCUUAAAUGUCUUUAA		[2046-2064]
485	ACAGUGUGCCCUAGCUUUU	AAAAGCUAGGGCACACUGU		[2456-2474]
					486	GCAGUUAACCUUCAAGACA	UGUCUUGAAGGUUAACUGC		[2989-3007]
487	AGUUUUAGAAGUCAGUAGA	UCUACUGACUUCUAAAACU	Ms	[3634-3652]
					488	CUGAGUCAUUUGCAGUGUU	AACACUGCAAAUGACUCAG		[3361-3379]
489	GCUAAAUCUCUCUGCCUGU	ACAGGCAGAGAGAUUUAGC		[2250-2268]
					490	CAGAACACCAGCAGUUAAC	GUUAACUGCUGGUGUUCUG		[2979-2997]
491	ACUCCAGCUCCUACUACAG	CUGUAGUAGGAGCUGGAGU		[1712-1730]
					492	GCGUAUGAAUCUCCUGGAC	GUCCAGGAGAUUCAUACGC	大鼠，Ms	[369-387]
493	CAAUAGUCUAGAGAAGCAU	AUGCUUCUCUAGACUAUUG		[2679-2697]
					494	AUCUGUUGUUAAAUUAUGU	ACAUAAUUUAACAACAGAU	Ms	[3141-3159]
495	UCUCCAACAUCGAGACCUU	AAGGUCUCGAUGUUGGAGA		[1220-1238]
					496	CCCGGAUUACAAGUACCAG	CUGGUACUUGUAAUCCGGG		[879-897]
497	GUGCUGCUGGGAAACAUUU	AAAUGUUUCCCAGCAGCAC		[2761-2779]

498	ACAAACAUGACCUAUCCAA	UUGGAUAGGUCAUGUUUGU		[2093-2111]
					499	AAGGACCACCCGGAUUACA	UGUAAUCCGGGUGGUCCUU		[871-889]
500	CAGAACUCCAGCUCCUACU	AGUAGGAGCUGGAGUUCUG		[1708-1726]

表B 34SPP1-分泌的磷蛋白1

表B 35TP53BP2-肿瘤蛋白p53结合蛋白，2

No.	正义链siRNA	反义链siRNA	其他Sp	人-72534661：272-3655
					1	CAGGGAAGACGAAGAUGAA	UUCAUCUUCGUCUUCCCUG	Chmp	[3532-3550]
2	GGAGAACCAUGAAAACGAA	UUCGUUUUCAUGGUUCUCC	Mnk	[2323-2341]
					3	GAAUGAGGGUGAAAUUCAA	UUGAAUUUCACCCUCAUUC	Chmp，Mnk	[3024-3042]
4	CGCUGAGGGAGAAAGAGAA	UUCUCUUUCUCCCUCAGCG		[1605-1623]

5	AGACGAAGAUGAAAUCGAA	UUCGAUUUCAUCUUCGUCU	Chmp	[3538-3556]
					6	GAGUGAUGCUGACCUAGAA	UUCUAGGUCAGCAUCACUC	Mnk	[2407-2425]
7	GGUUGUCAGUGAACAAUAA	UUAUUGUUCACUGACAACC		[4169-4187]
					8	CCAGAAUAACCCAGAAGAA	UUCUUCUGGGUUAUUCUGG	Chmp	[2800-2818]
9	GGAUCUGACUCUUGCUGAA	UUCAGCAAGAGUCAGAUCC	Chmp，Mnk	[640-658]
					10	GAUCAUAGCUGACUUUAAA	UUUAAAGUCAGCUAUGAUC		[4374-4392]
11	CCGUGUAUCUCAGUAACAA	UUGUUACUGAGAUACACGG	Mnk	[288-306]
					12	GCUUGAAAGCGAUGAAGAA	UUCUUCAUCGCUUUCAAGC	Mnk	[3763-3781]
13	CAAACUAAAGGCUCUAAAA	UUUUAGAGCCUUUAGUUUG	Mnk	[1466-1484]
					14	UGCUCAGGUUGCAAAUAAA	UUUAUUUGCAACCUGAGCA		[1729-1747]
15	GGGAGAAUUUGACCUUGUA	UACAAGGUCAAAUUCUCCC	Chmp，Mnk	[3076-3094]
					16	GAAUAAGCGUAAUUCAGAA	UUCUGAAUUACGCUUAUUC	Mnk	[1141-1159]
17	GGUGGAUCUGUGCAAAGAA	UUCUUUGCACAGAUCCACC	Mnk	[361-379]
					18	CCUGGUGAAUAUCGAAGAA	UUCUUCGAUAUUCACCAGG	Chmp，Mnk	[593-611]
19	GAUCCAAGUUUAAAAAGAA	UUCUUUUUAAACUUGGAUC	Chmp，Mnk	[560-578]
					20	GGAUCAAGUUGAUGAUGGA	UCCAUCAUCAACUUGAUCC	Mnk	[1579-1597]
21	CAUGGGAACUAAACCAAAA	UUUUGGUUUAGUUCCCAUG		[1885-1903]
					22	UGAGCAGGAGAAACUUAAA	UUUAAGUUUCUCCUGCUCA		[781-799]
23	GGACAUUUAGCGUGAUGAA	UUCAUCACGCUAAAUGUCC		[3825-3843]
					24	CAGAGAACAUUUAUUCCAA	UUGGAAUAAAUGUUCUCUG	Mnk	[2247-2265]
25	CGAGCGUCGAAGAGACAAA	UUUGUCUCUUCGACGCUCG		[18-36]
					26	GGAAGCUAAGCUAAAAAAA	UUUUUUUAGCUUAGCUUCC	Chmp，Mnk	[826-844]
27	CAUGGAUAAGCGUGUUAAU	AUUAACACGCUUAUCCAUG	Mnk	[1168-1186]
					28	CAUCCACAGGGAAGACGAA	UUCGUCUUCCCUGUGGAUG	Chmp	[3526-3544]
29	GGCUGAAUUUUAAUCUGUA	UACAGAUUAAAAUUCAGCC		[4291-4309]
					30	CAUUGUGAGUGGACCAAGA	UCUUGGUCCACUCACAAUG	Chmp，Mnk	[535-553]
31	GGGCGCGCCUUAAUGAUAA	UUAUCAUUAAGGCGCGCCC	Chmp，Mnk	[3564-3582]

32	CCAGGUUCUAAGCAAGAAA	UUUCUUGCUUAGAACCUGG	Mnk	[1976-1994]
					33	GAGGGAGAAAGAGAAGAAA	UUUCUUCUCUUUCUCCCUC	大鼠，Ms	[1609-1627]
34	AGGACAAACUUGCGUAAAA	UUUUACGCAAGUUUGUCCU	Chmp，Mnk	[2981-2999]
					35	AGCUAAGAAACAAAUUGAA	UUCAAUUUGUUUCUUAGCU	Mnk	[1080-1098]
36	GCUCAGGUUGCAAAUAAAA	UUUUAUUUGCAACCUGAGC		[1730-1748]
					37	GGUACAGUUUGGUGUAAAU	AUUUACACCAAACUGUACC	Chmp，Mnk	[3202-3220]
38	GCAUCUUAAGAAUUAUACA	UGUAUAAUUCUUAAGAUGC	Mnk	[4210-4228]
					39	CGUGUAUCUCAGUAACAAU	AUUGUUACUGAGAUACACG	Mnk	[289-307]
40	CCAGUAAUUAGAUGUAGAA	UUCUACAUCUAAUUACUGG	Mnk	[4261-4279]
					41	UGAUGAGCUGCCCAUGAAA	UUUCAUGGGCAGCUCAUCA	Chmp，Mnk	[3487-3505]
42	CAGGAUCCAAGUUUAAAAA	UUUUUAAACUUGGAUCCUG	Chmp，Mnk	[557-575]
					43	CGUGGUGGAUCUGUGCAAA	UUUGCACAGAUCCACCACG		[358-376]
44	GAAGAAGAAGGCAGCUCUA	UAGAGCUGCCUUCUUCUUC	Mnk	[1207-1225]
					45	GAAGGAGACUGCAUGACAA	UUGUCAUGCAGUCUCCUUC	Chmp，Mnk	[3506-3524]
46	GCAGAUAAGUGCGAGGAAA	UUUCCUCGCACUUAUCUGC	Chmp，Mnk	[3356-3374]
					47	GCCCAAAUCUCCAGAAUAA	UUAUUCUGGAGAUUUGGGC	Chmp	[2790-2808]
48	CAAGAAUCCUGUCUAGUAA	UUACUAGACAGGAUUCUUG		[3937-3955]
					49	CAGGAAGCUAAGCUAAAAA	UUUUUAGCUUAGCUUCCUG	Chmp，Mnk	[824-842]
50	UCAGGAAGCUAAGCUAAAA	UUUUAGCUUAGCUUCCUGA	Chmp，Mnk	[823-841]
					51	GGAGAAACUUAAAAGGCUA	UAGCCUUUUAAGUUUCUCC	Chmp	[787-805]
52	GACUGUACCCAAGAAUUAA	UUAAUUCUUGGGUACAGUC		[3612-3630]
					53	UGCGCUUUGGGAUUAUGAA	UUCAUAAUCCCAAAGCGCA		[3457-3475]
54	CCGUAAUAUUUGUCAAGAU	AUCUUGACAAAUAUUACGG		[4358-4376]
					55	CAACGAUUUGGAAGUCAGA	UCUGACUUCCAAAUCGUUG	Chmp	[467-485]
56	CACCAAGGCCUCUAAAGAA	UUCUUUAGAGGCCUUGGUG		[2451-2469]
					57	GGCUGCUUCACAAACUAAA	UUUAGUUUGUGAAGCAGCC	Mnk	[1456-1474]
58	CCAUGGGAACUAAACCAAA	UUUGGUUUAGUUCCCAUGG		[1884-1902]

59	GAAACAAAUUGAAUCAAGA	UCUUGAUUCAAUUUGUUUC	Mnk	[1086-1104]
					60	GCUGCAGCUAAGAAACAAA	UUUGUUUCUUAGCUGCAGC	Mnk	[1075-1093]
61	ACUUGUGGAGGAAAUUGAA	UUCAAUUUCCUCCACAAGU	Mnk	[895-913]
					62	GAGCAGGAGAAACUUAAAA	UUUUAAGUUUCUCCUGCUC	Chmp	[782-800]
63	AGAUCAUAGCUGACUUUAA	UUAAAGUCAGCUAUGAUCU		[4373-4391]
					64	CUGGGACUGUACCCAAGAA	UUCUUGGGUACAGUCCCAG		[3608-3626]
65	AAAGGAGAACGGUGUUAAU	AUUAACACCGUUCUCCUUU	Chmp	[610-628]
					66	GUUGGUUGUCAGUGAACAA	UUGUUCACUGACAACCAAC		[4166-4184]
67	AGAAUUAAACCAAGACAAA	UUUGUCUUGGUUUAAUUCU	Ms，Mnk	[3623-3641]
					68	AGAUGGGCAUAAUGAAUAA	UUAUUCAUUAUGCCCAUCU	Chmp，Mnk	[3426-3444]
69	CAUUGUGCUGCCUCAUGUA	UACAUGAGGCAGCACAAUG	Chmp，Mnk	[3257-3275]
					70	CAUUUAGCGUGAUGAAAUA	UAUUUCAUCACGCUAAAUG		[3828-3846]
71	CAGAGGGAGUGUUUGAAUA	UAUUCAAACACUCCCUCUG	大鼠，Ms，Mnk	[1127-1145]
					72	CAGUUUGGUGUAAAUGUAA	UUACAUUUACACCAAACUG	Chmp，Mnk	[3206-3224]
73	CUCAGAAAGCCCAGUAGAA	UUCUACUGGGCUUUCUGAG	Mnk	[2608-2626]
					74	AGAAGAUGGGCAUAAUGAA	UUCAUUAUGCCCAUCUUCU	Ms，Chmp，Mnk	[3423-3441]
75	AGCUCUACAGCAAAAAGAA	UUCUUUUUGCUGUAGAGCU	Mnk	[1219-1237]
					76	GGAGAACGGUGUUAAUAGU	ACUAUUAACACCGUUCUCC	Chmp	[613-631]
77	CGAUGUUUCUUACCGUGUA	UACACGGUAAGAAACAUCG		[276-294]
					78	GGACUGUACCCAAGAAUUA	UAAUUCUUGGGUACAGUCC		[3611-3629]
79	GCGCUUAAAGUUUUUGAAA	UUUCAAAAACUUUAAGCGC	Chmp，Mnk	[730-748]
					80	GACCAAGACUCAUACCAGA	UCUGGUAUGAGUCUUGGUC	Mnk	[2161-2179]
81	CUCAGGUUGCAAAUAAAAA	UUUUUAUUUGCAACCUGAG		[1731-1749]
					82	GAGACUAAGCAAUGGGAAA	UUUCCCAUUGCUUAGUCUC	Mnk	[877-895]
83	CCAGAGUGAUGCUGACCUA	UAGGUCAGCAUCACUCUGG	Mnk	[2404-2422]
					84	CCAGCAGCAACAGAUUGAA	UUCAAUCUGUUGCUGCUGG	Chmp，Mnk	[679-697]
85	GAACCAUGAAAACGAAAGA	UCUUUCGUUUUCAUGGUUC	Mnk	[2326-2344]

86	AGUUCAGGAGAACCAUGAA	UUCAUGGUUCUCCUGAACU	Mnk	[2317-2335]
					87	GCUCUACAGCAAAAAGAAA	UUUCUUUUUGCUGUAGAGC	Mnk	[1220-1238]
88	CCAAGAUCUCAGGAUCCAA	UUGGAUCCUGAGAUCUUGG	Chmp，Mnk	[548-566]
					89	UCAGGAUCCAAGUUUAAAA	UUUUAAACUUGGAUCCUGA	Chmp，Mnk	[556-574]
90	CAGCUAAGAAACAAAUUGA	UCAAUUUGUUUCUUAGCUG	Mnk	[1079-1097]
					91	UGUGCUGCCUCAUGUAACA	UGUUACAUGAGGCAGCACA	Chmp，Mnk	[3260-3278]
92	CAGACUUACCCGUAAUAUU	AAUAUUACGGGUAAGUCUG		[4349-4367]
					93	GAGAAUGAAGGAUUGAAGA	UCUUCAAUCCUUCAUUCUC		[3793-3811]
94	GAAUUUUAGUCAAUGAAGA	UCUUCAUUGACUAAAAUUC	Mnk	[3668-3686]
					95	GAAUGUCUCUAGAAGAGAA	UUCUCUUCUAGAGACAUUC		[3779-3797]
96	GGCCUGAAUUGCUGGUGAA	UUCACCAGCAAUUCAGGCC	Mnk	[1353-1371]
					97	GUAGCUUGAAAGCGAUGAA	UUCAUCGCUUUCAAGCUAC	Mnk	[3760-3778]
98	AGGGAAGACGAAGAUGAAA	UUUCAUCUUCGUCUUCCCU	Chmp	[3533-3551]
					99	GACCUAGAAGCCUUACGAA	UUCGUAAGGCUUCUAGGUC		[2417-2435]
100	AGAGGGAGUGUUUGAAUAA	UUAUUCAAACACUCCCUCU	大鼠，Ms，Mnk	[1128-1146]
					101	GGGAGAAAGAGAAGAAAGU	ACUUUCUUCUCUUUCUCCC	大鼠，Ms	[1611-1629]
102	CAGAAUUUUAGUCAAUGAA	UUCAUUGACUAAAAUUCUG	Mnk	[3666-3684]
					103	GGGCUGCUUCACAAACUAA	UUAGUUUGUGAAGCAGCCC	Mnk	[1455-1473]
104	CCGUGUAGCACUCAGAUAA	UUAUCUGAGUGCUACACGG		[3892-3910]
					105	GGAUAAGCGUGUUAAUGAG	CUCAUUAACACGCUUAUCC	Mnk	[1171-1189]
106	CUGAGAAUCAGGAAGCUAA	UUAGCUUCCUGAUUCUCAG	Chmp，Mnk	[816-834]
					107	AGCGCUUAAAGUUUUUGAA	UUCAAAAACUUUAAGCGCU	Chmp，Mnk	[729-747]
108	CCUACAAAACCAAAACAGA	UCUGUUUUGGUUUUGUAGG	Mnk	[1775-1793]
					109	GAAUCAGGAAGCUAAGCUA	UAGCUUAGCUUCCUGAUUC	Chmp，Mnk	[820-838]
110	CCAUGAAAACGAAAGAAUU	AAUUCUUUCGUUUUCAUGG	Mnk	[2329-2347]
					111	GCUACAGACUUACCCGUAA	UUACGGGUAAGUCUGUAGC		[4345-4363]
112	AAAAGUGAGAGCACUUAAA	UUUAAGUGCUCUCACUUUU	Chmp，Mnk	[841-859]

113	CCAGUUACUCCAGAAACAA	UUGUUUCUGGAGUAACUGG	Mnk	[329-347]
					114	CAGAAAGCCCAGUAGAAAU	AUUUCUACUGGGCUUUCUG	Mnk	[2610-2628]
115	GAAGGCAGCUCUACAGCAA	UUGCUGUAGAGCUGCCUUC	Mnk	[1213-1231]
					116	UGAGGGAGAAAGAGAAGAA	UUCUUCUCUUUCUCCCUCA	大鼠，Ms，Mnk	[1608-1626]
117	GGAUCCAAGUUUAAAAAGA	UCUUUUUAAACUUGGAUCC	Chmp，Mnk	[559-577]
					118	GCACCAAGGCCUCUAAAGA	UCUUUAGAGGCCUUGGUGC		[2450-2468]
119	GGCAGUCCAGAACCUGAAA	UUUCAGGUUCUGGACUGCC	Mnk	[2282-2300]
					120	UUUGUAGGCUGAAUUUUAA	UUAAAAUUCAGCCUACAAA		[4285-4303]
121	GAAAGGAGAACGGUGUUAA	UUAACACCGUUCUCCUUUC	Chmp	[609-627]
					122	CCCAAGAAUUAAACCAAGA	UCUUGGUUUAAUUCUUGGG	Ms，Mnk	[3619-3637]
123	AGGCAGCUCUACAGCAAAA	UUUUGCUGUAGAGCUGCCU	Mnk	[1215-1233]
					124	CUAAGGAACAGCGCUUAAA	UUUAAGCGCUGUUCCUUAG	Chmp，Mnk	[720-738]
125	CGUGGAACAGAAGAGACUA	UAGUCUCUUCUGUUCCACG	Mnk	[865-883]
					126	CUUAAAAGGCUAAAAGAAA	UUUCUUUUAGCCUUUUAAG	Chmp，Mnk	[794-812]
127	CAAUGUAGCUUGAAAGCGA	UCGCUUUCAAGCUACAUUG	Mnk	[3756-3774]
					128	GCUUAAAGUUUUUGAAACA	UGUUUCAAAAACUUUAAGC	Chmp，Mnk	[732-750]
129	CUGUUAAGAAGAAGUAAUA	UAUUACUUCUUCUUAACAG		[3695-3713]
					130	GGAUGCUCAGGUUGCAAAU	AUUUGCAACCUGAGCAUCC		[1726-1744]
131	ACCGGCUGUGGAAGAAGAA	UUCUUCUUCCACAGCCGGU	大鼠，Ms，Mnk	[1197-1215]
					132	GGGCAUAAUGAAUAAAGGA	UCCUUUAUUCAUUAUGCCC	Chmp，Mnk	[3430-3448]
133	CCUUGUACAGAGAAUUAUU	AAUAAUUCUCUGUACAAGG	Mnk	[3088-3106]
					134	CCACAGGGAAGACGAAGAU	AUCUUCGUCUUCCCUGUGG	Chmp	[3529-3547]
135	GCGACAAUCCUGUUUUCUA	UAGAAAACAGGAUUGUCGC	Mnk	[3918-3936]
					136	GCUGAAUUUUAAUCUGUAU	AUACAGAUUAAAAUUCAGC		[4292-4310]
137	AGAAGAAGGCAGCUCUACA	UGUAGAGCUGCCUUCUUCU	Mnk	[1209-1227]
					138	GUAGCAUCUUAAGAAUUAU	AUAAUUCUUAAGAUGCUAC	Mnk	[4207-4225]
139	CAACAGAGGGAGUGUUUGA	UCAAACACUCCCUCUGUUG	大鼠，Ms，Mnk	[1124-1142]

140	GUUCCUGGUGAAUAUCGAA	UUCGAUAUUCACCAGGAAC	Chmp，Mnk	[590-608]
					141	AAAAAGAAAUGGUGUAAAA	UUUUACACCAUUUCUUUUU	Chmp，Mnk	[571-589]
142	GGCACUGCACACUUGUAUA	UAUACAAGUGUGCAGUGCC	Chmp	[4127-4145]
					143	CUGAGCAGGAGAAACUUAA	UUAAGUUUCUCCUGCUCAG		[780-798]
144	CUCUCUGCCUCCUGGUAAA	UUUACCAGGAGGCAGAGAG	Mnk	[2962-2980]
					145	AAUGUUUGAUGUUCUUCAA	UUGAAGAACAUCAAACAUU	Chmp	[451-469]
146	AACAGAAGAGACUAAGCAA	UUGCUUAGUCUCUUCUGUU	Mnk	[870-888]
					147	CAGAUAAGUGCGAGGAAAU	AUUUCCUCGCACUUAUCUG	Chmp，Mnk	[3357-3375]
148	UAAAGUUUUUGAAACAACA	UGUUGUUUCAAAAACUUUA	Mnk	[735-753]
					149	CUAGAAGCCUUACGAAAGA	UCUUUCGUAAGGCUUCUAG		[2420-2438]
150	GACUUAUUUUAAUGACAAU	AUUGUCAUUAAAAUAAGUC	Mnk	[3741-3759]
					151	UGUAAAAGUUCCUGGUGAA	UUCACCAGGAACUUUUACA	Chmp，Mnk	[583-601]
152	CAGACACUGCCCAACAUGA	UCAUGUUGGGCAGUGUCUG	大鼠	[1430-1448]
					153	CAAUGAGCAGCACUUCACA	UGUGAAGUGCUGCUCAUUG	Mnk	[304-322]
154	UGGGAAUGCUCUGGAUCAA	UUGAUCCAGAGCAUUCCCA	Mnk	[1567-1585]
					155	CCAUCAUACCCAUCCAAGU	ACUUGGAUGGGUAUGAUGG	大鼠，Mnk	[2570-2588]
156	CAGUGAACAAUAACUUUAU	AUAAAGUUAUUGUUCACUG		[4175-4193]
					157	GAUGAAGAAUGUCUCUAGA	UCUAGAGACAUUCUUCAUC	Mnk	[3773-3791]
158	GAAGAAUGUCUCUAGAAGA	UCUUCUAGAGACAUUCUUC	Mnk	[3776-3794]
					159	GCAUCACGGCUCUUCACAA	UUGUGAAGAGCCGUGAUGC	Chmp，Mnk	[3144-3162]
160	AGACUUAUUUUAAUGACAA	UUGUCAUUAAAAUAAGUCU	Mnk	[3740-3758]
					161	AGUUUGGUGUAAAUGUAAA	UUUACAUUUACACCAAACU	Chmp，Mnk	[3207-3225]
162	CCUUAUUUUGGACAAACUA	UAGUUUGUCCAAAAUAAGG	Mnk	[1802-1820]
					163	CCACGUGGAACAGAAGAGA	UCUCUUCUGUUCCACGUGG	Mnk	[862-880]
164	CGAUGAAAAUACAGACACU	AGUGUCUGUAUUUUCAUCG		[1419-1437]
					165	GAAACUUGCUACAGACUUA	UAAGUCUGUAGCAAGUUUC		[4338-4356]
166	GAAUUAUACAUAUGUUUGA	UCAAACAUAUGUAUAAUUC	Mnk	[4219-4237]

167	ACAGUUUGGUGUAAAUGUA	UACAUUUACACCAAACUGU	Chmp，Mnk	[3205-3223]
					168	ACUGUACCCAAGAAUUAAA	UUUAAUUCUUGGGUACAGU		[3613-3631]
169	CCAUCUCUGUCCCAUCAUA	UAUGAUGGGACAGAGAUGG	Mnk	[2559-2577]
					170	GAGCUUGAUCGCCUCUAUA	UAUAGAGGCGAUCAAGCUC	Mnk	[1052-1070]
171	AAAGUUUUUGAAACAACAA	UUGUUGUUUCAAAAACUUU	Mnk	[736-754]
					172	AGGAGCUGCAGCUAAGAAA	UUUCUUAGCUGCAGCUCCU	Mnk	[1071-1089]
173	GGACAUUGUGAGUGGACCA	UGGUCCACUCACAAUGUCC	Chmp，Mnk	[532-550]
					174	AAAAGUUCCUGGUGAAUAU	AUAUUCACCAGGAACUUUU	Chmp，Mnk	[586-604]
175	UACGAAAGAAACUGUCUAA	UUAGACAGUUUCUUUCGUA		[2430-2448]
					176	AGCUAGAGAUGCUCAAGAA	UUCUUGAGCAUCUCUAGCU		[990-1008]
177	GAUUGAAGCCCAGCAACAA	UUGUUGCUGGGCUUCAAUC	Chmp，Mnk	[691-709]
					178	CCAGUUUCAUCUGAUGGAA	UUCCAUCAGAUGAAACUGG	Mnk	[1244-1262]
179	GAAACUGUCUAACGCACCA	UGGUGCGUUAGACAGUUUC		[2437-2455]
					180	AGGAAGCUAAGCUAAAAAA	UUUUUUAGCUUAGCUUCCU	Chmp，Mnk	[825-843]
181	AGGAAAUUGAACAGAUGAA	UUCAUCUGUUCAAUUUCCU	大鼠，Mnk	[903-921]
					182	CCACUCAGCCCAACUAAAU	AUUUAGUUGGGCUGAGUGG	Mnk	[2354-2372]
183	GUGGAACAGAAGAGACUAA	UUAGUCUCUUCUGUUCCAC	Mnk	[866-884]
					184	CUUGUAUAUUGUCAGUGAA	UUCACUGACAAUAUACAAG		[4138-4156]
185	GGCAGCUAGAGAUGCUCAA	UUGAGCAUCUCUAGCUGCC		[987-1005]
					186	GUCCCAUCAUACCCAUCCA	UGGAUGGGUAUGAUGGGAC	大鼠，Mnk	[2567-2585]
187	AUCCAAGUUUAAAAAGAAA	UUUCUUUUUAAACUUGGAU	Chmp，Mnk	[561-579]
					188	GAGUUUUUGUAGCAUCUUA	UAAGAUGCUACAAAAACUC		[4199-4217]
189	GGACAAACUUGCGUAAAAC	GUUUUACGCAAGUUUGUCC	Chmp，Mnk	[2982-3000]
					190	GUCCGUUCUCAAUGUUUGA	UCAAACAUUGAGAACGGAC	Mnk	[1632-1650]
191	AAGAAUUAAACCAAGACAA	UUGUCUUGGUUUAAUUCUU	Ms，Mnk	[3622-3640]
					192	CUUCUUCCUUCGUCAUGAA	UUCAUGACGAAGGAAGAAG	Chmp，Mnk	[499-517]
193	ACCUCCUGUUCCUACAAAA	UUUUGUAGGAACAGGAGGU	Mnk	[1765-1783]

194	CCAUGUAUACGCAACAGCA	UGCUGUUGCGUAUACAUGG		[2100-2118]
					195	GAAGUAAUACGAUUAUUUU	AAAAUAAUCGUAUUACUUC	Mnk	[3705-3723]
196	GAAGAACCAGAGCAGUGAA	UUCACUGCUCUGGUUCUUC	Mnk	[1696-1714]
					197	CACCAUUAGAGGACAUUUA	UAAAUGUCCUCUAAUGGUG		[3815-3833]
198	CAAGAAUUAAACCAAGACA	UGUCUUGGUUUAAUUCUUG	Ms，Mnk	[3621-3639]
					199	GCAGCAAGUUCAAUAUAUU	AAUAUAUUGAACUUGCUGC	Mnk	[2081-2099]
200	CCCAGAAGAACCAAAUCCA	UGGAUUUGGUUCUUCUGGG	Chmp	[2809-2827]
					201	GGGAUGCUCAGGUUGCAAA	UUUGCAACCUGAGCAUCCC		[1725-1743]
202	AAUUUUAGUCAAUGAAGAA	UUCUUCAUUGACUAAAAUU	Mnk	[3669-3687]
					203	CUUUGGAGGGAGAAUUUGA	UCAAAUUCUCCCUCCAAAG	Chmp，Mnk	[3069-3087]
204	AAGGCAGCUCUACAGCAAA	UUUGCUGUAGAGCUGCCUU	Mnk	[1214-1232]
					205	GAAUAACCCAGAAGAACCA	UGGUUCUUCUGGGUUAUUC	Chmp	[2803-2821]
206	GAGCGUAUCGCUCAUGGAA	UUCCAUGAGCGAUACGCUC		[3008-3026]
					207	ACAGCAAAAAGAAAAUCUA	UAGAUUUUCUUUUUGCUGU	Mnk	[1225-1243]
208	CUCUGUUAAGAAGAAGUAA	UUACUUCUUCUUAACAGAG		[3693-3711]
					209	GCCCAGUAGAAAUCCAGAA	UUCUGGAUUUCUACUGGGC	Mnk	[2616-2634]
210	ACUUAAAAGGCUAAAAGAA	UUCUUUUAGCCUUUUAAGU	Chmp	[793-811]
					211	CACUCAGCCCAACUAAAUU	AAUUUAGUUGGGCUGAGUG	Mnk	[2355-2373]
212	GCGUUGACCAAGACUCAUA	UAUGAGUCUUGGUCAACGC	Mnk	[2156-2174]
					213	AAUUGAAUCAAGAGCAGAA	UUCUGCUCUUGAUUCAAUU	Mnk	[1092-1110]
214	UGAGCAGCACUUCACAGAA	UUCUGUGAAGUGCUGCUCA	Ms，Mnk	[307-325]
					215	AGAUAAGUAUACAGCGACA	UGUCGCUGUAUACUUAUCU		[3905-3923]
216	CCUGUUCCUACAAAACCAA	UUGGUUUUGUAGGAACAGG	Mnk	[1769-1787]
					217	CCCUGAUUGGAGUCCUUCA	UGAAGGACUCCAAUCAGGG	Mnk	[1498-1516]
218	CAUGCAGACUGCUGCAGAU	AUCUGCAGCAGUCUGCAUG	Chmp，Mnk	[3343-3361]
					219	AAAUGUAAAUGCUGCUGAU	AUCAGCAGCAUUUACAUUU	Chmp，Mnk	[3217-3235]
220	UAAGCUACGGUACCAGUAA	UUACUGGUACCGUAGCUUA		[4249-4267]

221	GGUCCAAGAUGAUGCCGAU	AUCGGCAUCAUCUUGGACC	Mnk	[261-279]
					222	GAAGAAGUAAUACGAUUAU	AUAAUCGUAUUACUUCUUC	Mnk	[3702-3720]
223	GAGACUGCAUGACAAUCAU	AUGAUUGUCAUGCAGUCUC	Chmp，Mnk	[3510-3528]
					224	CCAUGACAAUCAGUCUGCA	UGCAGACUGAUUGUCAUGG		[1027-1045]
225	UGGUGAAUAUCGAAGAAAG	CUUUCUUCGAUAUUCACCA	Chmp，Mnk	[595-613]
					226	GACCUUGUACAGAGAAUUA	UAAUUCUCUGUACAAGGUC	大鼠，Mnk	[3086-3104]
227	CACAGAAGUUCCAGUUACU	AGUAACUGGAACUUCUGUG	Mnk	[319-337]
					228	GAGAACCAUGAAAACGAAA	UUUCGUUUUCAUGGUUCUC	Mnk	[2324-2342]
229	UCAGGUUGCAAAUAAAAAU	AUUUUUAUUUGCAACCUGA		[1732-1750]
					230	GACGAAGAUGAAAUCGAAU	AUUCGAUUUCAUCUUCGUC	Chmp	[3539-3557]
231	GUAUAUUGUCAGUGAAGAA	UUCUUCACUGACAAUAUAC		[4141-4159]
					232	GGUGAAUAUCGAAGAAAGG	CCUUUCUUCGAUAUUCACC	Chmp，Mnk	[596-614]
233	AGGGAUAUGUUCCACGUAA	UUACGUGGAACAUAUCCCU	Chmp	[3585-3603]
					234	CGCGUUGACCAAGACUCAU	AUGAGUCUUGGUCAACGCG	Mnk	[2155-2173]
235	AGUUUUUGUAGCAUCUUAA	UUAAGAUGCUACAAAAACU		[4200-4218]
					236	UCUCAGGAUCCAAGUUUAA	UUAAACUUGGAUCCUGAGA	Chmp，Mnk	[554-572]
237	GAAACGUAGUUCUAUUACA	UGUAAUAGAACUACGUUUC	Mnk	[2467-2485]
					238	ACGCACCAAGGCCUCUAAA	UUUAGAGGCCUUGGUGCGU		[2448-2466]
239	UGCUCUGGAUCAAGUUGAU	AUCAACUUGAUCCAGAGCA	Mnk	[1573-1591]
					240	GAGGAAGGCUACACUCAGU	ACUGAGUGUAGCCUUCCUC	Chmp，Mnk	[3377-3395]
241	CCACCUCCUGUUCCUACAA	UUGUAGGAACAGGAGGUGG	大鼠，Mnk	[1763-1781]
					242	GCACCCAGAGAACAUUUAU	AUAAAUGUUCUCUGGGUGC	Mnk	[2242-2260]
243	GUACCAGUAAUUAGAUGUA	UACAUCUAAUUACUGGUAC	Mnk	[4258-4276]
					244	GCGUGAUGAAAUAAAGCAU	AUGCUUUAUUUCAUCACGC		[3834-3852]
245	AAGAAUUAAUCUCUGUUAA	UUAACAGAGAUUAAUUCUU		[3683-3701]
					246	GUUUGUAGGCUGAAUUUUA	UAAAAUUCAGCCUACAAAC		[4284-4302]
247	GAAUAUCGAAGAAAGGAGA	UCUCCUUUCUUCGAUAUUC	Chmp，Mnk	[599-617]

248	GGAUAAUGAGCGAAUGUUU	AAACAUUCGCUCAUUAUCC	Chmp，Mnk	[439-457]
					249	AUCAGGAAGCUAAGCUAAA	UUUAGCUUAGCUUCCUGAU	Chmp，Mnk	[822-840]
250	GGGCCGAUGAAAAUACAGA	UCUGUAUUUUCAUCGGCCC	Mnk	[1415-1433]
					251	GAAAUUGAACAGAUGAAUA	UAUUCAUCUGUUCAAUUUC	Mnk	[905-923]
252	ACUAAGGAACAGCGCUUAA	UUAAGCGCUGUUCCUUAGU	Chmp，Mnk	[719-737]
					253	UCACAAGACUUAUUUUAAU	AUUAAAAUAAGUCUUGUGA	Mnk	[3735-3753]
254	AAGCUACGGUACCAGUAAU	AUUACUGGUACCGUAGCUU		[4250-4268]
					255	CUCAUGUAACAACGUCCAA	UUGGACGUUGUUACAUGAG	Chmp，Mnk	[3268-3286]
256	GAGAAACUUAAAAGGCUAA	UUAGCCUUUUAAGUUUCUC	Chmp	[788-806]
					257	GGGACUGUACCCAAGAAUU	AAUUCUUGGGUACAGUCCC		[3610-3628]
258	GUCUCUAGAAGAGAAUGAA	UUCAUUCUCUUCUAGAGAC		[3783-3801]
					259	AGAUCAGCGACAACAGCAA	UUGCUGUUGUCGCUGAUCU	Chmp，Mnk	[754-772]
260	GGCAGCUCUACAGCAAAAA	UUUUUGCUGUAGAGCUGCC	Mnk	[1216-1234]
					261	GAAUAAAGGAGUCAUUUAU	AUAAAUGACUCCUUUAUUC	Chmp，Mnk	[3439-3457]
262	UGAAGAAUUCACCAUUAGA	UCUAAUGGUGAAUUCUUCA		[3806-3824]
					263	CACUGGGAAUGCUCUGGAU	AUCCAGAGCAUUCCCAGUG	Mnk	[1564-1582]
264	CCAAGGCUCUGCUUCUGUA	UACAGAAGCAGAGCCUUGG		[1537-1555]
					265	GUAUAUGGUAAGCCUGUAA	UUACAGGCUUACCAUAUAC	Mnk	[2198-2216]
266	CUCUGCUUCUGUACCUCAA	UUGAGGUACAGAAGCAGAG		[1543-1561]
					267	GGUUCGGGUCCAAGAUGAU	AUCAUCUUGGACCCGAACC	Mnk	[255-273]
268	GCUGCUAUCUCCCAGCAUA	UAUGCUGGGAGAUAGCAGC		[1927-1945]
					269	GUAUCUCAGAAAUUAGAAA	UUUCUAAUUUCUGAGAUAC		[4323-4341]
270	GGAAACUUGUGGAGGAAAU	AUUUCCUCCACAAGUUUCC	Mnk	[891-909]
					271	CGUCUACUAUGCCUCGGAU	AUCCGAGGCAUAGUAGACG		[1326-1344]
272	CUCAGGAUCCAAGUUUAAA	UUUAAACUUGGAUCCUGAG	Chmp，Mnk	[555-573]
					273	UGACAAUCAUCCACAGGGA	UCCCUGUGGAUGAUUGUCA	Chmp，Mnk	[3519-3537]
274	CUACAAAACCAAAACAGAU	AUCUGUUUUGGUUUUGUAG	Mnk	[1776-1794]

275	GUUCUUCAACGAUUUGGAA	UUCCAAAUCGUUGAAGAAC	Chmp	[461-479]
					276	AGCUGCAGCUAAGAAACAA	UUGUUUCUUAGCUGCAGCU	Mnk	[1074-1092]
277	GACACUGCCCAACAUGAGA	UCUCAUGUUGGGCAGUGUC		[1432-1450]
					278	AACGCACCAAGGCCUCUAA	UUAGAGGCCUUGGUGCGUU		[2447-2465]
279	AGGAGAACCAUGAAAACGA	UCGUUUUCAUGGUUCUCCU	Mnk	[2322-2340]
					280	AUGACAAUGUAGCUUGAAA	UUUCAAGCUACAUUGUCAU	Mnk	[3752-3770]
281	CCUUUGGUACUCUGAGGAA	UUCCUCAGAGUACCAAAGG	Mnk	[1680-1698]
					282	CAGAAGAACCAAAUCCAGA	UCUGGAUUUGGUUCUUCUG	Chmp	[2811-2829]
283	CUUAUUUUGGACAAACUAA	UUAGUUUGUCCAAAAUAAG	Mnk	[1803-1821]
					284	CAGUUUCAUCUGAUGGAAA	UUUCCAUCAGAUGAAACUG	Mnk	[1245-1263]
285	AAUCCUUACCGAAACCAGA	UCUGGUUUCGGUAAGGAUU	Mnk	[2390-2408]
					286	CUCCAGGCCUUGAUUAUGA	UCAUAAUCAAGGCCUGGAG	Chmp	[2748-2766]
287	AAUUAAUCUCUGUUAAGAA	UUCUUAACAGAGAUUAAUU		[3686-3704]
					288	GCGAAUGUUUGAUGUUCUU	AAGAACAUCAAACAUUCGC	Chmp	[448-466]
289	GGGAAGACGAAGAUGAAAU	AUUUCAUCUUCGUCUUCCC	Chmp	[3534-3552]
					290	CAGCGCUUAAAGUUUUUGA	UCAAAAACUUUAAGCGCUG	Chmp，Mnk	[728-746]
291	AGUUCUCAGCAGUUGUCAA	UUGACAACUGCUGAGAACU	Mnk	[1853-1871]
					292	CAGUUACUCCAGAAACAAU	AUUGUUUCUGGAGUAACUG	Mnk	[330-348]
293	UGAGCUGCCCAUGAAAGAA	UUCUUUCAUGGGCAGCUCA	Chmp，Mnk	[3490-3508]
					294	CAGCUCUACAGCAAAAAGA	UCUUUUUGCUGUAGAGCUG	Mnk	[1218-1236]
295	CAGGGACAUUGUGAGUGGA	UCCACUCACAAUGUCCCUG	Ms，Chmp，Mnk	[529-547]
					296	UACCCGUAAUAUUUGUCAA	UUGACAAAUAUUACGGGUA		[4355-4373]
297	AGUUCCAGUUACUCCAGAA	UUCUGGAGUAACUGGAACU	Mnk	[325-343]
					298	AGUUGAUGAUGGAGAGGUU	AACCUCUCCAUCAUCAACU	Mnk	[1585-1603]
299	UAAUCUCUGUUAAGAAGAA	UUCUUCUUAACAGAGAUUA		[3689-3707]
					300	CCUGGUACAGUUUGGUGUA	UACACCAAACUGUACCAGG	Chmp，Mnk	[3199-3217]
301	GAAAGAGAAGAAAGUGCGU	ACGCACUUUCUUCUCUUUC	大鼠，Ms	[1615-1633]

302	GCACUUCACAGAAGUUCCA	UGGAACUUCUGUGAAGUGC	Mnk	[313-331]
					303	CAGUUGUAAUAAACUUUUU	AAAAAGUUUAUUACAACUG	Mnk	[4395-4413]
304	UACAGAGAAUUAUUUAUGA	UCAUAAAUAAUUCUCUGUA	Mnk	[3093-3111]
					305	GCAAAAAUUUCACAAGACU	AGUCUUGUGAAAUUUUUGC	Mnk	[3726-3744]
306	UCAGAAAGCCCAGUAGAAA	UUUCUACUGGGCUUUCUGA	Mnk	[2609-2627]
					307	GCUGCAGUAGGUCCCUAUA	UAUAGGGACCUACUGCAGC	Mnk	[1301-1319]
308	GACAAUCAUCCACAGGGAA	UUCCCUGUGGAUGAUUGUC	Chmp	[3520-3538]
					309	AAUCCAGAAUCCAUAUUUA	UAAAUAUGGAUUCUGGAUU	Mnk	[2626-2644]
310	CCUCCUGGUAAAAGGACAA	UUGUCCUUUUACCAGGAGG	Chmp，Mnk	[2969-2987]
					311	AAUCCUGUUUUCUACAAGA	UCUUGUAGAAAACAGGAUU	Mnk	[3923-3941]
312	AUGAUGAGCUGCCCAUGAA	UUCAUGGGCAGCUCAUCAU	Chmp，Mnk	[3486-3504]
					313	AAGAGAAUGAAGGAUUGAA	UUCAAUCCUUCAUUCUCUU		[3791-3809]
314	GAACCAGAGCAGUGAAGAU	AUCUUCACUGCUCUGGUUC	Mnk	[1699-1717]
					315	AAAAAGUGAGAGCACUUAA	UUAAGUGCUCUCACUUUUU	Chmp，Mnk	[840-858]
316	GAGAAUUUGACCUUGUACA	UGUACAAGGUCAAAUUCUC	Chmp，Mnk	[3078-3096]
					317	AGAAUGAAGGAUUGAAGAA	UUCUUCAAUCCUUCAUUCU		[3794-3812]
318	AGUGUUUGAAUAAGCGUAA	UUACGCUUAUUCAAACACU	Mnk	[1134-1152]
					319	UCCAGUUACUCCAGAAACA	UGUUUCUGGAGUAACUGGA	Mnk	[328-346]
320	AAAGGACAAACUUGCGUAA	UUACGCAAGUUUGUCCUUU	Chmp，Mnk	[2979-2997]
					321	CCAAGAUGAUGCCGAUGUU	AACAUCGGCAUCAUCUUGG	Mnk	[264-282]
322	UACGGUACCAGUAAUUAGA	UCUAAUUACUGGUACCGUA		[4254-4272]
					323	CUCAAUGUUUGAUGCAGUA	UACUGCAUCAAACAUUGAG	Mnk	[1639-1657]
324	CGACAAUCCUGUUUUCUAC	GUAGAAAACAGGAUUGUCG	Mnk	[3919-3937]
					325	CAAAACCAAAACAGAUUAA	UUAAUCUGUUUUGGUUUUG	Mnk	[1779-1797]
326	ACCAGUAAUUAGAUGUAGA	UCUACAUCUAAUUACUGGU	Mnk	[4260-4278]
					327	UGGUUGUCAGUGAACAAUA	UAUUGUUCACUGACAACCA		[4168-4186]
328	GAGUGUUUGAAUAAGCGUA	UACGCUUAUUCAAACACUC	Mnk	[1133-1151]

329	AGAGAACAUUUAUUCCAAU	AUUGGAAUAAAUGUUCUCU	Mnk	[2248-2266]
					330	ACAGAAUUUUAGUCAAUGA	UCAUUGACUAAAAUUCUGU	Mnk	[3665-3683]
331	GCUAAGAAACAAAUUGAAU	AUUCAAUUUGUUUCUUAGC	Mnk	[1081-1099]
					332	CUAAGCUACGGUACCAGUA	UACUGGUACCGUAGCUUAG		[4248-4266]
333	UAAUGACAAUGUAGCUUGA	UCAAGCUACAUUGUCAUUA	Mnk	[3750-3768]
					334	GUUUGAUGUUCUUCAACGA	UCGUUGAAGAACAUCAAAC	Chmp	[454-472]
335	GAGGGAGUGUUUGAAUAAG	CUUAUUCAAACACUCCCUC	大鼠，Ms，Mnk	[1129-1147]
					336	CGUGUAGCACUCAGAUAAG	CUUAUCUGAGUGCUACACG		[3893-3911]
337	UAGUAAAUAGGAUCAUUUA	UAAAUGAUCCUAUUUACUA		[3950-3968]
					338	GACGGAAGUUCUCAGCAGU	ACUGCUGAGAACUUCCGUC		[1847-1865]
339	GAGGAAAUUGAACAGAUGA	UCAUCUGUUCAAUUUCCUC	大鼠，Mnk	[902-920]
					340	GGAAUGAGGGUGAAAUUCA	UGAAUUUCACCCUCAUUCC	Chmp，Mnk	[3023-3041]
341	GCAAGAAAGUCCACCUGCU	AGCAGGUGGACUUUCUUGC	Mnk	[1987-2005]
					342	CCACACUUUUCAAGUGUAU	AUACACUUGAAAAGUGUGG	Mnk	[2183-2201]
343	CCCGUAAUAUUUGUCAAGA	UCUUGACAAAUAUUACGGG		[4357-4375]
					344	GAAACUUAAAAGGCUAAAA	UUUUAGCCUUUUAAGUUUC	Chmp	[790-808]
345	AGUUUUUGAAACAACAAGA	UCUUGUUGUUUCAAAAACU	Mnk	[738-756]
					346	GUUCAGGAGAACCAUGAAA	UUUCAUGGUUCUCCUGAAC	Mnk	[2318-2336]
347	AGGAGAAGAUGGGCAUAAU	AUUAUGCCCAUCUUCUCCU	Ms，Chmp，Mnk	[3420-3438]
					348	GAAAGUGCGUCCGUUCUCA	UGAGAACGGACGCACUUUC		[1624-1642]
349	AUAAUUUGUUCCAGCAAAA	UUUUGCUGGAACAAAUUAU		[921-939]
					350	GAAGCUAAGCUAAAAAAAG	CUUUUUUUAGCUUAGCUUC	Chmp，Mnk	[827-845]
351	GAGCUGCAGCUAAGAAACA	UGUUUCUUAGCUGCAGCUC	Mnk	[1073-1091]
					352	AACUUAAAAGGCUAAAAGA	UCUUUUAGCCUUUUAAGUU	Chmp	[792-810]
353	UAGCAUCUUAAGAAUUAUA	UAUAAUUCUUAAGAUGCUA	Mnk	[4208-4226]
					354	UGCAGAUAAGUGCGAGGAA	UUCCUCGCACUUAUCUGCA	Chmp，Mnk	[3355-3373]
355	GCUCAGAAAGCCCAGUAGA	UCUACUGGGCUUUCUGAGC	Mnk	[2607-2625]

356	UUCAGCAGCUGCUCCUAAA	UUUAGGAGCAGCUGCUGAA		[4010-4028]
					357	UGUCUUUUGUAUCUCAGAA	UUCUGAGAUACAAAAGACA	Mnk	[4315-4333]
358	UGGAUAAGCGUGUUAAUGA	UCAUUAACACGCUUAUCCA	Mnk	[1170-1188]
					359	GGAUUAUGAACCUCAGAAU	AUUCUGAGGUUCAUAAUCC	Chmp，Mnk	[3466-3484]
360	UCUCCAGAAUAACCCAGAA	UUCUGGGUUAUUCUGGAGA	Chmp	[2797-2815]
					361	CAAAGACACCUUACUUCCA	UGGAAGUAAGGUGUCUUUG	Mnk	[2038-2056]
362	GAAUAAUUUGUUCCAGCAA	UUGCUGGAACAAAUUAUUC		[919-937]
					363	GAGAACAUUUAUUCCAAUA	UAUUGGAAUAAAUGUUCUC	Mnk	[2249-2267]
364	GCGACAACAGCAACAAGUU	AACUUGUUGCUGUUGUCGC	Chmp，Mnk	[760-778]
					365	AAUCAGGAAGCUAAGCUAA	UUAGCUUAGCUUCCUGAUU	Chmp，Mnk	[821-839]
366	GAAGAGAAUGAAGGAUUGA	UCAAUCCUUCAUUCUCUUC		[3790-3808]
					367	CUCUACAGCAAAAAGAAAA	UUUUCUUUUUGCUGUAGAG	Mnk	[1221-1239]
368	AAAGUGCGUCCGUUCUCAA	UUGAGAACGGACGCACUUU		[1625-1643]
					369	GACUCUUGCUGAACUUCAG	CUGAAGUUCAGCAAGAGUC	Chmp，Mnk	[646-664]
370	CCCAGACAACAGCCCAAAU	AUUUGGGCUGUUGUCUGGG	Chmp，Mnk	[2779-2797]
					371	CUCCCAAUUUCUUUAUGGA	UCCAUAAAGAAAUUGGGAG	Chmp	[3397-3415]
372	AGUUCCUGGUGAAUAUCGA	UCGAUAUUCACCAGGAACU	Chmp，Mnk	[589-607]
					373	CAAUGUUUGAUGCAGUAGA	UCUACUGCAUCAAACAUUG	Mnk	[1641-1659]
374	ACCAAGGCCUCUAAAGAAA	UUUCUUUAGAGGCCUUGGU		[2452-2470]
					375	ACGUGGUGGAUCUGUGCAA	UUGCACAGAUCCACCACGU		[357-375]
376	GCAAGUUCAAUAUAUUCCA	UGGAAUAUAUUGAACUUGC	Mnk	[2084-2102]
					377	GAUGAUGAGCUGCCCAUGA	UCAUGGGCAGCUCAUCAUC	Chmp，Mnk	[3485-3503]
378	AGCUUGAUCGCCUCUAUAA	UUAUAGAGGCGAUCAAGCU	Mnk	[1053-1071]
					379	AACUGACCAGGCAGCUAGA	UCUAGCUGCCUGGUCAGUU		[978-996]
380	CAAUCAUCCACAGGGAAGA	UCUUCCCUGUGGAUGAUUG	Chmp	[3522-3540]
					381	GACAAACUUGCGUAAAACU	AGUUUUACGCAAGUUUGUC	Chmp	[2983-3001]
382	UGUAGCAUCUUAAGAAUUA	UAAUUCUUAAGAUGCUACA	Mnk	[4206-4224]

383	AAAUUGAACAGAUGAAUAA	UUAUUCAUCUGUUCAAUUU		[906-924]
					384	CCUCAUGUAACAACGUCCA	UGGACGUUGUUACAUGAGG	Chmp，Mnk	[3267-3285]
385	GAAUGUUUGAUGUUCUUCA	UGAAGAACAUCAAACAUUC	大鼠，Chmp	[450-468]
					386	GCCUUAUUUUGGACAAACU	AGUUUGUCCAAAAUAAGGC	Mnk	[1801-1819]
387	CUGGUAAAAGGACAAACUU	AAGUUUGUCCUUUUACCAG	Chmp，Mnk	[2973-2991]
					388	UACCCAAGAAUUAAACCAA	UUGGUUUAAUUCUUGGGUA	Ms，Mnk	[3617-3635]
389	CUGUUCCUACAAAACCAAA	UUUGGUUUUGUAGGAACAG	Mnk	[1770-1788]
					390	GGAGGAAAUUGAACAGAUG	CAUCUGUUCAAUUUCCUCC	大鼠，Mnk	[901-919]
391	UAAUAUUUGUCAAGAUCAU	AUGAUCUUGACAAAUAUUA		[4361-4379]
					392	GUAACUUGCUGGGACUGUA	UACAGUCCCAGCAAGUUAC		[3600-3618]
393	GACUUUAAAAACAGUUGUA	UACAACUGUUUUUAAAGUC	Mnk	[4384-4402]
					394	CCCGUGUAGCACUCAGAUA	UAUCUGAGUGCUACACGGG		[3891-3909]
395	AAAUACAGACACUGCCCAA	UUGGGCAGUGUCUGUAUUU		[1425-1443]
					396	CGGUGUUAAUAGUCCUAGG	CCUAGGACUAUUAACACCG	Chmp	[619-637]
397	GUCUUUUGUAUCUCAGAAA	UUUCUGAGAUACAAAAGAC	Mnk	[4316-4334]
					398	UUUAGUCAAUGAAGAAUUA	UAAUUCUUCAUUGACUAAA	Mnk	[3672-3690]
399	GGCAGCAAGUUCAAUAUAU	AUAUAUUGAACUUGCUGCC	Mnk	[2080-2098]
					400	AGCCCAGUAGAAAUCCAGA	UCUGGAUUUCUACUGGGCU	Mnk	[2615-2633]
401	AGCAGCUGCUCCUAAACCA	UGGUUUAGGAGCAGCUGCU		[4013-4031]
					402	GUUAGUUGGUUGUCAGUGA	UCACUGACAACCAACUAAC		[4162-4180]
403	CCAGAGAACAUUUAUUCCA	UGGAAUAAAUGUUCUCUGG	Mnk	[2246-2264]
					404	GAAUUAAUCUCUGUUAAGA	UCUUAACAGAGAUUAAUUC		[3685-3703]
405	AGACUUACCCGUAAUAUUU	AAAUAUUACGGGUAAGUCU		[4350-4368]
					406	UGAAUAAGCGUAAUUCAGA	UCUGAAUUACGCUUAUUCA	Mnk	[1140-1158]
407	GGAUGGACUCCAUUACAUU	AAUGUAAUGGAGUCCAUCC	Chmp，Mnk	[3242-3260]
					408	CCCUUGCUUUACUGCUAGA	UCUAGCAGUAAAGCAAGGG	Chmp，Mnk	[3045-3063]
409	GAUUUGGAAGUCAGAGGAA	UUCCUCUGACUUCCAAAUC	Chmp，Mnk	[471-489]

410	GGCGCGCCUUAAUGAUAAG	CUUAUCAUUAAGGCGCGCC	Chmp，Mnk	[3565-3583]
					411	GCGCCUUAAUGAUAAGGAG	CUCCUUAUCAUUAAGGCGC	Chmp，Mnk	[3568-3586]
412	GGCUCCACAUGUGCUUGAU	AUCAAGCACAUGUGGAGCC		[2830-2848]
					413	ACAAACUAAAGGCUCUAAA	UUUAGAGCCUUUAGUUUGU	Mnk	[1465-1483]
414	UGAUGUUCUUCAACGAUUU	AAAUCGUUGAAGAACAUCA	Chmp	[457-475]
					415	CUUGCUGAACUUCAGGAAA	UUUCCUGAAGUUCAGCAAG	Chmp，Mnk	[650-668]
416	GACAUUUAGCGUGAUGAAA	UUUCAUCACGCUAAAUGUC		[3826-3844]
					417	GUUCCAGUUACUCCAGAAA	UUUCUGGAGUAACUGGAAC	Mnk	[326-344]
418	CAAAAAUUUCACAAGACUU	AAGUCUUGUGAAAUUUUUG	Mnk	[3727-3745]
					419	GUUUGGUGUAAAUGUAAAU	AUUUACAUUUACACCAAAC	Chmp，Mnk	[3208-3226]
420	GCUACGGUACCAGUAAUUA	UAAUUACUGGUACCGUAGC		[4252-4270]
					421	GAAGAAUUAAUCUCUGUUA	UAACAGAGAUUAAUUCUUC		[3682-3700]
422	GAAGAAGGCAGCUCUACAG	CUGUAGAGCUGCCUUCUUC	Mnk	[1210-1228]
					423	GGAAAUUGAACAGAUGAAU	AUUCAUCUGUUCAAUUUCC	Mnk	[904-922]
424	CAGUUCAGGAGAACCAUGA	UCAUGGUUCUCCUGAACUG	Mnk	[2316-2334]
					425	CUUAAAGUUUUUGAAACAA	UUGUUUCAAAAACUUUAAG	Mnk	[733-751]
426	GGGAACUAAACCAAAACCA	UGGUUUUGGUUUAGUUCCC		[1888-1906]
					427	GUGAAUAUCGAAGAAAGGA	UCCUUUCUUCGAUAUUCAC	Chmp，Mnk	[597-615]
428	CCAGAAGAACCAAAUCCAG	CUGGAUUUGGUUCUUCUGG	Chmp	[2810-2828]
					429	CCAGUACAGAGAACAGUGA	UCACUGUUCUCUGUACUGG	大鼠，Chmp，Mnk	[2715-2733]
430	GUAUUUAUUGUCUUUUGUA	UACAAAAGACAAUAAAUAC	Mnk	[4307-4325]
					431	GAGGGAUAUGUUCCACGUA	UACGUGGAACAUAUCCCUC	Chmp	[3584-3602]
432	AAGAAUCCUGUCUAGUAAA	UUUACUAGACAGGAUUCUU		[3938-3956]
					433	ACAGAUUGAAGCCCAGCAA	UUGCUGGGCUUCAAUCUGU	Chmp，Mnk	[688-706]
434	CACCCAGAGAACAUUUAUU	AAUAAAUGUUCUCUGGGUG	大鼠，Mnk	[2243-2261]
					435	AGUUGCUGAGCAGGAGAAA	UUUCUCCUGCUCAGCAACU		[775-793]
436	CAAGUUGCUGAGCAGGAGA	UCUCCUGCUCAGCAACUUG	Mnk	[773-791]

437	UAGUCAAUGAAGAAUUAAU	AUUAAUUCUUCAUUGACUA	Mnk	[3674-3692]
					438	UCAAUAUAUUCCAUGUAUA	UAUACAUGGAAUAUAUUGA	Mnk	[2090-2108]
439	AGAGACUAAGCAAUGGGAA	UUCCCAUUGCUUAGUCUCU	Mnk	[876-894]
					440	GGAAGUUCUCAGCAGUUGU	ACAACUGCUGAGAACUUCC	Mnk	[1850-1868]
441	GGGAUUAUGAACCUCAGAA	UUCUGAGGUUCAUAAUCCC	Chmp，Mnk	[3465-3483]
					442	GUGCGAGGAAAUGGAGGAA	UUCCUCCAUUUCCUCGCAC	大鼠，Ms，Chmp，Mnk	[3364-3382]
443	GUCCAGUUGCGGAUAAUGA	UCAUUAUCCGCAACUGGAC	Chmp，Mnk	[429-447]
					444	CUUUAAAAACAGUUGUAAU	AUUACAACUGUUUUUAAAG	Mnk	[4386-4404]
445	GCAACAGAUUGAAGCCCAG	CUGGGCUUCAAUCUGUUGC	Chmp，Mnk	[685-703]
					446	UCUGCUUCUGUACCUCAAA	UUUGAGGUACAGAAGCAGA		[1544-1562]
447	UGAGCUUGAUCGCCUCUAU	AUAGAGGCGAUCAAGCUCA	Mnk	[1051-1069]
					448	AGAAGCCUUACGAAAGAAA	UUUCUUUCGUAAGGCUUCU		[2422-2440]
449	GCUGAGCAGGAGAAACUUA	UAAGUUUCUCCUGCUCAGC		[779-797]
					450	UGGGAAACUUGUGGAGGAA	UUCCUCCACAAGUUUCCCA	Mnk	[889-907]
451	AUCUCAGGAUCCAAGUUUA	UAAACUUGGAUCCUGAGAU	Chmp，Mnk	[553-571]
					452	AGACCAGACCCUUUCUCCA	UGGAGAAAGGGUCUGGUCU	Mnk	[1960-1978]
453	CGGAUGGUUCCUUGGUCAU	AUGACCAAGGAACCAUCCG	Mnk	[1383-1401]
					454	AGAAGUUCCAGUUACUCCA	UGGAGUAACUGGAACUUCU	Mnk	[322-340]
455	UUAGUUGGUUGUCAGUGAA	UUCACUGACAACCAACUAA		[4163-4181]
					456	AACAGAGGGAGUGUUUGAA	UUCAAACACUCCCUCUGUU	大鼠，Ms，Mnk	[1125-1143]
457	UGAGAAUCAGGAAGCUAAG	CUUAGCUUCCUGAUUCUCA	Chmp，Mnk	[817-835]
					458	GUAGCACUCAGAUAAGUAU	AUACUUAUCUGAGUGCUAC		[3896-3914]
459	ACGGUACCAGUAAUUAGAU	AUCUAAUUACUGGUACCGU		[4255-4273]
					460	GAAGAUGGGCAUAAUGAAU	AUUCAUUAUGCCCAUCUUC	Chmp，Mnk	[3424-3442]
461	CCUGGUAAAAGGACAAACU	AGUUUGUCCUUUUACCAGG	Chmp，Mnk	[2972-2990]
					462	AGUUUCAUCUGAUGGAAAU	AUUUCCAUCAGAUGAAACU	Mnk	[1246-1264]
463	GUUGUUCCGUCCAUGGGAA	UUCCCAUGGACGGAACAAC	Mnk	[1874-1892]

464	CAUCUUAAGAAUUAUACAU	AUGUAUAAUUCUUAAGAUG	Mnk	[4211-4229]
					465	UUUUGUAGCAUCUUAAGAA	UUCUUAAGAUGCUACAAAA		[4203-4221]
466	GGGAAACUUGUGGAGGAAA	UUUCCUCCACAAGUUUCCC	Mnk	[890-908]
					467	AGGAAAUGGAGGAAGGCUA	UAGCCUUCCUCCAUUUCCU	大鼠，Ms，Chmp，Mnk	[3369-3387]
468	CGUUGACCAAGACUCAUAC	GUAUGAGUCUUGGUCAACG	Mnk	[2157-2175]
					469	CUCCAGGUUCUAAGCAAGA	UCUUGCUUAGAACCUGGAG	Mnk	[1974-1992]
470	CUGCAGCUAAGAAACAAAU	AUUUGUUUCUUAGCUGCAG	Mnk	[1076-1094]
					471	GAUGUUUCUUACCGUGUAU	AUACACGGUAAGAAACAUC		[277-295]
472	CUGGUACAGUUUGGUGUAA	UUACACCAAACUGUACCAG	Chmp，Mnk	[3200-3218]
					473	UUAUGAGGUUGAUGACCCA	UGGGUCAUCAACCUCAUAA	Chmp，Mnk	[3106-3124]
474	CUGCCUCCUGGUAAAAGGA	UCCUUUUACCAGGAGGCAG	Chmp，Mnk	[2966-2984]
					475	GGUCUCUCUGGUUCCUGAA	UUCAGGAACCAGAGAGACC	Chmp	[2668-2686]
476	CGAUUUGGAAGUCAGAGGA	UCCUCUGACUUCCAAAUCG	Chmp，Mnk	[470-488]
					477	AAGGCACUGCACACUUGUA	UACAAGUGUGCAGUGCCUU	Chmp	[4125-4143]
478	CACAAACUAAAGGCUCUAA	UUAGAGCCUUUAGUUUGUG	Mnk	[1464-1482]
					479	AGAAGAAGUAAUACGAUUA	UAAUCGUAUUACUUCUUCU	Mnk	[3701-3719]
480	GCUUCUGUACCUCAAAGCA	UGCUUUGAGGUACAGAAGC		[1547-1565]
					481	CUCUCUGGUUCCUGAAUCA	UGAUUCAGGAACCAGAGAG	Chmp	[2671-2689]
482	AACCAUGAAAACGAAAGAA	UUCUUUCGUUUUCAUGGUU	Mnk	[2327-2345]
					483	ACCUAGAAGCCUUACGAAA	UUUCGUAAGGCUUCUAGGU		[2418-2436]
484	CUACGGUACCAGUAAUUAG	CUAAUUACUGGUACCGUAG		[4253-4271]
					485	GCAUGACAAUCAUCCACAG	CUGUGGAUGAUUGUCAUGC	Chmp，Mnk	[3516-3534]
486	GGAUAUGUUCCACGUAACU	AGUUACGUGGAACAUAUCC	Chmp	[3587-3605]
					487	UGGUGGAUCUGUGCAAAGA	UCUUUGCACAGAUCCACCA	大鼠，Mnk	[360-378]
488	CUGGUGAAUAUCGAAGAAA	UUUCUUCGAUAUUCACCAG	Chmp，Mnk	[594-612]
					489	UGGUACAGUUUGGUGUAAA	UUUACACCAAACUGUACCA	Chmp，Mnk	[3201-3219]
490	UCCAGGUUCUAAGCAAGAA	UUCUUGCUUAGAACCUGGA	Mnk	[1975-1993]

491	CUGGGAAUGCUCUGGAUCA	UGAUCCAGAGCAUUCCCAG	Mnk	[1566-1584]
					492	AGAAAAUCUACCAGUUUCA	UGAAACUGGUAGAUUUUCU	Mnk	[1234-1252]
493	AUGCUCAGGUUGCAAAUAA	UUAUUUGCAACCUGAGCAU		[1728-1746]
					494	AGGAUUGAAGAAUUCACCA	UGGUGAAUUCUUCAAUCCU		[3801-3819]
495	GGGAGUGUUUGAAUAAGCG	CGCUUAUUCAAACACUCCC	大鼠，Ms，Mnk	[1131-1149]
					496	CACCUCCUGUUCCUACAAA	UUUGUAGGAACAGGAGGUG	大鼠，Mnk	[1764-1782]
497	UUACUUCCACCCUUCAGAA	UUCUGAAGGGUGGAAGUAA	Mnk	[2048-2066]
					498	UCUAGAAGAGAAUGAAGGA	UCCUUCAUUCUCUUCUAGA		[3786-3804]
499	UGAAUAAAGGAGUCAUUUA	UAAAUGACUCCUUUAUUCA	Chmp，Mnk	[3438-3456]
					500	ACAACAAGAUCAGCGACAA	UUGUCGCUGAUCUUGUUGU	Mnk	[748-766]

表B 36XIAP-X-连接凋亡抑制剂

No.	正义链siRNA	反义链siRNA	其他Sp	人-32528298：129-1622
					1	GGAGCUUUCUGUAUAUAAA	UUUAUAUACAGAAAGCUCC		[1980-1998]
2	GCAUCAUACUAUAACUGAA	UUCAGUUAUAGUAUGAUGC		[1867-1885]
					3	UGGUGUUUCUCAUAGAUAA	UUAUCUAUGAGAAACACCA		[5608-5626]
4	GCAUGUUACUACAGAGGAA	UUCCUCUGUAGUAACAUGC		[3317-3335]
					5	CGUAUUUAAUGAUAGAAUA	UAUUCUAUCAUUAAAUACG		[2200-2218]
6	GGACAAUCAUCAAUGCAUA	UAUGCAUUGAUGAUUGUCC		[6568-6586]
					7	GGGCUAAAACUUAGAAAAA	UUUUUCUAAGUUUUAGCCC		[5549-5567]
8	GGACAAGUCCUAUUUUCAA	UUGAAAAUAGGACUUGUCC		[104-122]
					9	GAAAGAGAUUAGUACUGAA	UUCAGUACUAAUCUCUUUC		[1424-1442]
10	AGAAAAUAAUGGAGGAAAA	UUUUCCUCCAUUAUUUUCU		[1297-1315]
					11	CAUCAAUAAGGAAGAAGAA	UUCUUCUUCCUUAUUGAUG		[176-194]
12	AGGAAUUUCCCAAAUUCAA	UUGAAUUUGGGAAAUUCCU	大鼠，Ms	[870-888]
					13	GAGGAAAGUUUGAGAGUAA	UUACUCUCAAACUUUCCUC		[3330-3348]
14	GGGACAAUUGUAUCUUCAA	UUGAAGAUACAAUUGUCCC		[7599-7617]
					15	UGAUGUGAACUGACUUUAA	UUAAAGUCAGUUCACAUCA		[1676-1694]

16	CAUGAGUUGUGAAAUUUAA	UUAAAUUUCACAACUCAUG		[4161-4179]
					17	CCAGAAUGGUCAGUACAAA	UUUGUACUGACCAUUCUGG		[458-476]
18	AGGAGACCAUGUAUGUAAA	UUUACAUACAUGGUCUCCU		[5455-5473]
					19	GUUGCUUCAGGUUCUUAAA	UUUAAGAACCUGAAGCAAC		[4234-4252]
20	CCAUGCUGGUGGAAAGAUA	UAUCUUUCCACCAGCAUGG		[2065-2083]
					21	CAACCAAGGAGGAAUUGAA	UUCAAUUCCUCCUUGGUUG		[6630-6648]
22	AGGUGAAGGUGAUAAAGUA	UACUUUAUCACCUUCACCU		[1004-1022]
					23	GGCUAAAACUUAGAAAAAA	UUUUUUCUAAGUUUUAGCC		[5550-5568]
24	GUGCAAAGAUUAUAGCUAA	UUAGCUAUAAUCUUUGCAC		[6392-6410]
					25	GGACAAUUGUAUCUUCAAA	UUUGAAGAUACAAUUGUCC		[7600-7618]
26	CAAAGAUUAUAGCUAAUUA	UAAUUAGCUAUAAUCUUUG		[6395-6413]
					27	UGUGAAUAAUCAUGUGAAA	UUUCACAUGAUUAUUCACA		[8215-8233]
28	UAAGAAGCAUCAUACUAUA	UAUAGUAUGAUGCUUCUUA		[1861-1879]
					29	GUAUAAACUAGAAGUUUAA	UUAAACUUCUAGUUUAUAC		[3226-3244]
30	GGGUUUUAAUGUAAUUUAU	AUAAAUUACAUUAAAACCC		[8127-8145]
					31	CAGUUUUGAAGGAUCUAAA	UUUAGAUCCUUCAAAACUG		[140-158]
32	GAGAAAACACCAUCACUAA	UUAGUGAUGGUGUUUUCUC		[1197-1215]
					33	CAACAAAUCUUCCAAGAAA	UUUCUUGGAAGAUUUGUUG		[886-904]
34	GGCUGGAAGUGACCUUAGA	UCUAAGGUCACUUCCAGCC		[6313-6331]
					35	GGCAUUCAUUGUAGAUUAA	UUAAUCUACAAUGAAUGCC		[8340-8358]
36	GGAUGAUUAAGAUGUAUAU	AUAUACAUCUUAAUCAUCC		[3019-3037]
					37	GGAAAGUUUGAGAGUAAAA	UUUUACUCUCAAACUUUCC		[3332-3350]
38	CAGGGUUUACAUUACAAGA	UCUUGUAAUGUAAACCCUG		[3264-3282]
					39	GAUAGAGAUUGUUUUUAGA	UCUAAAAACAAUCUCUAUC		[2080-2098]
40	CUACCAAGUAGGAAAAAAA	UUUUUUUCCUACUUGGUAG		[1725-1743]
					41	GAGGCAACUGAGACUCAAA	UUUGAGUCUCAGUUGCCUC		[6360-6378]
42	GGUCAAACCCUUAAAAAUA	UAUUUUUAAGGGUUUGACC		[6129-6147]

43	CCGGAAUCUUAAUAUUCGA	UCGAAUAUUAAGAUUCCGG		[824-842]
					44	AAGGGACAAGAAUAUAUAA	UUAUAUAUUCUUGUCCCUU	大鼠	[1128-1146]
45	CAGUGAAGACCCUUGGGAA	UUCCCAAGGGUCUUCACUG		[1064-1082]
					46	GGUUCUGGUUGCAGAUCUA	UAGAUCUGCAACCAGAACC		[1352-1370]
47	CGGCUUUUAUCUUGAAAAU	AUUUUCAAGAUAAAAGCCG		[410-428]
					48	CAAGGUUGCAAGAGCUCAA	UUGAGCUCUUGCAACCUUG		[5437-5455]
49	GGAUAUACUCAGUUAACAA	UUGUUAACUGAGUAUAUCC		[952-970]
					50	CCAUCUAAUUCCGCAAAAA	UUUUUGCGGAAUUAGAUGG		[4341-4359]
51	CUGUGAAAGGAAAAUAAUA	UAUUAUUUUCCUUUCACAG		[5409-5427]
					52	AAGAGAAGAUGACUUUUAA	UUAAAAGUCAUCUUCUCUU	大鼠	[121-139]
53	GAAGGGACAAGAAUAUAUA	UAUAUAUUCUUGUCCCUUC	大鼠	[1127-1145]
					54	UGGUCAGUACAAAGUUGAA	UUCAACUUUGUACUGACCA		[464-482]
55	CGAGCAGGGUUUCUUUAUA	UAUAAAGAAACCCUGCUCG		[273-291]
					56	AGUAGUAGAUACUUCUGAA	UUCAGAAGUAUCUACUACU		[3092-3110]
57	GAGCCGCACUUCAUUAAAA	UUUUAAUGAAGUGCGGCUC		[4089-4107]
					58	UGUUAAGUGUAAAAUGCAA	UUGCAUUUUACACUUAACA		[2262-2280]
59	CACAGGUAUUGGUGACCAA	UUGGUCACCAAUACCUGUG		[701-719]
					60	GGACUGAAUUGUUUUAACA	UGUUAAAACAAUUCAGUCC		[4050-4068]
61	AGAGGAGAAGCUUUGCAAA	UUUGCAAAGCUUCUCCUCU	大鼠，Ms	[1463-1481]
					62	GAGUAAAACUGUAAAAAAU	AUUUUUUACAGUUUUACUC		[3343-3361]
63	GUAUUAGUAUUGUGAAUAA	UUAUUCACAAUACUAAUAC		[8205-8223]
					64	AGAUAUGUUAAGUGUAAAA	UUUUACACUUAACAUAUCU		[2257-2275]
65	GGUAUAAACUAGAAGUUUA	UAAACUUCUAGUUUAUACC		[3225-3243]
					66	CUGAUUUUGUAAAAUGAAA	UUUCAUUUUACA A A AUCAG	Ms	[2753-2771]
67	GGACAAGAAUAUAUAAACA	UGUUUAUAUAUUCUUGUCC		[1131-1149]
					68	GAUUAAAGUCCUUUCAGAA	UUCUGAAAGGACUUUAAUC		[625-643]
69	CCUGGAAAUUUGGGCUAAA	UUUAGCCCAAAUUUCCAGG		[5538-5556]

70	GGUGGAAAACUGAAAAAUU	AAUUUUUCAGUUUUCCACC	大鼠	[738-756]
					71	ACAAGAUUCUCACAACAAA	UUUGUUGUGAGAAUCUUGU		[3277-3295]
72	CUCAGAUCUUCCAAUUAAU	AUUAAUUGGAAGAUCUGAG	Ms	[2784-2802]
					73	GAAAAUAAUGGAGGAAAAA	UUUUUCCUCCAUUAUUUUC		[1298-1316]
74	GAGGAGAAGCUUUGCAAAA	UUUUGCAAAGCUUCUCCUC	大鼠，Ms	[1464-1482]
					75	GGGUGUAGUGAGUGUAUAU	AUAUACACUCACUACACCC		[4718-4736]
76	AGUAGAUACUUCUGAAAUA	UAUUUCAGAAGUAUCUACU		[3095-3113]
					77	CAAAAGAUUUGGAAAGAUA	UAUCUUUCCAAAUCUUUUG		[2345-2363]
78	GAUCAUUUGCAAAGUCAAA	UUUGACUUUGCAAAUGAUC		[4362-4380]
					79	GCAGGUUGUAGAUAUAUCA	UGAUAUAUCUACAACCUGC		[560-578]
80	GCUGGUGGAAAGAUAGAGA	UCUCUAUCUUUCCACCAGC		[2069-2087]
					81	AGAGUAAAACUGUAAAAAA	UUUUUUACAGUUUUACUCU		[3342-3360]
82	GGUGAAGGUGAUAAAGUAA	UUACUUUAUCACCUUCACC		[1005-1023]
					83	UGGGCAGGUUGUAGAUAUA	UAUAUCUACAACCUGCCCA		[557-575]
84	CAAGAUGAGUCAAGUCAGA	UCUGACUUGACUCAUCUUG		[1395-1413]
					85	GGAGGAAAAAAUUCAGAUA	UAUCUGAAUUUUUUCCUCC		[1307-1325]
86	AGGAAAGUUUGAGAGUAAA	UUUACUCUCAAACUUUCCU		[3331-3349]
					87	CCUGCUUUGUGGAUGAAAA	UUUUCAUCCACAAAGCAGG	Ms	[2669-2687]
88	GGAGCCGCACUUCAUUAAA	UUUAAUGAAGUGCGGCUCC		[4088-4106]
					89	GAAUAAAACGUAUUCAAUA	UAUUGAAUACGUUUUAUUC		[8374-8392]
90	GCAUAACAGAGUUAUAGAA	UUCUAUAACUCUGUUAUGC		[6288-6306]
					91	UACCAAGUAGGAAAAAAAA	UUUUUUUUCCUACUUGGUA		[1726-1744]
92	CCGGAUCUUUUCCAUCUAA	UUAGAUGGAAAAGAUCCGG		[4330-4348]
					93	AGUUUUGAAGGAUCUAAAA	UUUUAGAUCCUUCAAAACU		[141-159]
94	GAAGCAUCAUACUAUAACU	AGUUAUAGUAUGAUGCUUC		[1864-1882]
					95	GUCUUAUCUUGUUUCAAAA	UUUUGAAACAAGAUAAGAC		[2725-2743]
96	CCGUUAGGAUGAUUAAGAU	AUCUUAAUCAUCCUAACGG		[3013-3031]

97	CAACGGCUUUUAUCUUGAA	UUCAAGAUAAAAGCCGUUG		[407-425]
					98	AGUAGGGUAUAAACUAGAA	UUCUAGUUUAUACCCUACU		[3220-3238]
99	CCAUAACUUUCACUACAUA	UAUGUAGUGAAAGUUAUGG		[6520-6538]
					100	CAAGGACUCAAGGACUGAA	UUCAGUCCUUGAGUCCUUG		[4039-4057]
101	GGAGAAAAGUGUUAAAAUU	AAUUUUAACACUUUUCUCC		[3954-3972]
					102	CAAGGACAUUAAGAAAAUA	UAUUUUCUUAAUGUCCUUG		[1286-1304]
103	CAUAGUUCUUUUUAGUCAA	UUGACUAAAAAGAACUAUG		[5354-5372]
					104	GGAGACUCAGCAGUUGGAA	UUCCAACUGCUGAGUCUCC		[354-372]
105	CCAUUUUAGUGGAUAAAAU	AUUUUAUCCACUAAAAUGG		[4821-4839]
					106	GUGCAUACAUUAUAUGCAA	UUGCAUAUAAUGUAUGCAC		[7103-7121]
107	CGUAUUCAAUAAAAUACUA	UAGUAUUUUAUUGAAUACG		[8382-8400]
					108	AAGCGUAUUUAAUGAUAGA	UCUAUCAUUAAAUACGCUU		[2197-2215]
109	GUCUAGACUUUAAAUUUAA	UUAAAUUUAAAGUCUAGAC		[3921-3939]
					110	GGGAGAAAAGUGUUAAAAU	AUUUUAACACUUUUCUCCC		[3953-3971]
111	GUGCGAAUUAUUUUUUUAA	UUAAAAAAAUAAUUCGCAC		[2159-2177]
					112	GACUUUUAACAGUUUUGAA	UUCAAAACUGUUAAAAGUC	大鼠，Ms	[131-149]
113	GUGUAGUGAGUGUAUAUAA	UUAUAUACACUCACUACAC		[4720-4738]
					114	GGGUUUACAUUACAAGAUU	AAUCUUGUAAUGUAAACCC		[3266-3284]
115	GCUAAAACUUAGAAAAAAU	AUUUUUUCUAAGUUUUAGC		[5551-5569]
					116	GCAUUGUCUUAAUUUUUGA	UCAAAAAUUAAGACAAUGC		[4576-4594]
117	CUGGUUUUAGCAUUUACAA	UUGUAAAUGCUAAAACCAG		[4598-4616]
					118	CUGUCCAUUUUCUUUUAAA	UUUAAAAGAAAAUGGACAG		[2123-2141]
119	AGAACAGAAGGGACAAGAA	UUCUUGUCCCUUCUGUUCU		[1121-1139]
					120	CCACUUAUUUUACAUUUUA	UAAAAUGUAAAAUAAGUGG		[4483-4501]
121	GUACAAGAAGCUAUACGAA	UUCGUAUAGCUUCUUGUAC		[1254-1272]
					122	GCAUUAGUUUCACAUGAUA	UAUCAUGUGAAACUAAUGC		[4876-4894]
123	CACUUAGUUUGGUUAUAUA	UAUAUAACCAAACUAAGUG		[3875-3893]

124	CUGAAUUGUUUUAACAUAA	UUAUGUUAAAACAAUUCAG		[4053-4071]
					125	AAAAAUUGAUCAUUUGCAA	UUGCAAAUGAUCAAUUUUU		[4355-4373]
126	CUUUUGUUGUGGUGGAAAA	UUUUCCACCACAACAAAAG	大鼠	[728-746]
					127	GCAGUUUAUUCAUCUGUGA	UCACAGAUGAAUAAACUGC		[5396-5414]
128	GAGGGCUAACUGAUUGGAA	UUCCAAUCAGUUAGCCCUC		[1042-1060]
					129	CAUGGAUAUACUCAGUUAA	UUAACUGAGUAUAUCCAUG		[949-967]
130	GGUACAAGAAGCUAUACGA	UCGUAUAGCUUCUUGUACC		[1253-1271]
					131	GGUAAGAACUACUGAGAAA	UUUCUCAGUAGUUCUUACC		[1184-1202]
132	CUGCUUUGUGGAUGAAAAA	UUUUUCAUCCACAAAGCAG	Ms	[2670-2688]
					133	AGUGAAGAAGCUAGAUUAA	UUAAUCUAGCUUCUUCACU		[612-630]
134	AAGGCUUAGGCAUGUUCAA	UUGAACAUGCCUAAGCCUU	Ms	[2543-2561]
					135	GUUAGAGAAAUGAAAUAAA	UUUAUUUCAUUUCUCUAAC		[5006-5024]
136	ACAUGAUAUACCCUUUAAA	UUUAAAGGGUAUAUCAUGU		[4887-4905]
					137	AGAUUAAAGUCCUUUCAGA	UCUGAAAGGACUUUAAUCU		[624-642]
138	AGGUCAAACCCUUAAAAAU	AUUUUUAAGGGUUUGACCU		[6128-6146]
					139	GUAGAUACUUCUGAAAUAA	UUAUUUCAGAAGUAUCUAC		[3096-3114]
140	CAAACUAAAUUCCAGUUAA	UUAACUGGAAUUUAGUUUG		[4614-4632]
					141	CAGGACACUUCACUUCCAA	UUGGAAGUGAAGUGUCCUG		[3989-4007]
142	GGAAGAAGAAUUUGUAGAA	UUCUACAAAUUCUUCUUCC		[185-203]
					143	CCCUGUUUCUGUUUUAGUA	UACUAAAACAGAAACAGGG		[3820-3838]
144	CCAUCACUAACUAGAAGAA	UUCUUCUAGUUAGUGAUGG		[1206-1224]
					145	AUAUCAUCUUGUAUCUUAA	UUAAGAUACAAGAUGAUAU		[2975-2993]
146	AAUCAUCAAUGCAUAUAUA	UAUAUAUGCAUUGAUGAUU		[6572-6590]
					147	GGCUAGUAAUAGUAGUAGA	UCUACUACUAUUACUAGCC		[3082-3100]
148	AAAGAUUUGGAAAGAUAUA	UAUAUCUUUCCAAAUCUUU		[2347-2365]
					149	CAUUGUAGAUUAAAGCUUA	UAAGCUUUAAUCUACAAUG		[8346-8364]
150	CUGUAUCAUUAAUGUAAUA	UAUUACAUUAAUGAUACAG		[8035-8053]

151	CCAUCCUAAUACCCUUUUA	UAAAAGGGUAUUAGGAUGG		[5497-5515]
					152	GCUUAUGUAGGUAAAAGUA	UACUUUUACCUACAUAAGC		[2898-2916]
153	ACUCCAACUUCUAAUCAAA	UUUGAUUAGAAGUUGGAGU		[4263-4281]
					154	AGGUGAGUAAGGCAUGUUA	UAACAUGCCUUACUCACCU		[3306-3324]
155	UGUGGUGGAAAACUGAAAA	UUUUCAGUUUUCCACCACA	大鼠	[735-753]
					156	GGUCAGAUUCUACUUUGAA	UUCAAAGUAGAAUCUGACC		[7963-7981]
157	CACUCCAACUUCUAAUCAA	UUGAUUAGAAGUUGGAGUG		[4262-4280]
					158	CCAUGAGUUGUGAAAUUUA	UAAAUUUCACAACUCAUGG		[4160-4178]
159	GAACGUCCAGGGUUUACAU	AUGUAAACCCUGGACGUUC		[3257-3275]
					160	CAAGCUACCUUUCUUGAAA	UUUCAAGAAAGGUAGCUUG		[6461-6479]
161	CAUAGACUAAGAAUAAGAA	UUCUUAUUCUUAGUCUAUG		[1848-1866]
					162	CAUUUUUCUGGAUUUAGUA	UACUAAAUCCAGAAAAAUG		[8077-8095]
163	GUGAAUAAAACGUAUUCAA	UUGAAUACGUUUUAUUCAC		[8372-8390]
					164	AGUCAAAUCUACUUGUUAA	UUAACAAGUAGAUUUGACU		[5367-5385]
165	AACCAAGGAGGAAUUGAAA	UUUCAAUUCCUCCUUGGUU		[6631-6649]
					166	AGAUGUAUAUAGGACAAAA	UUUUGUCCUAUAUACAUCU		[3028-3046]
167	ACACCAUCACUAACUAGAA	UUCUAGUUAGUGAUGGUGU		[1203-1221]
					168	CAGGGAUAGCAAGGGACAA	UUGUCCCUUGCUAUCCCUG		[7587-7605]
169	UCAGCAUAACAGAGUUAUA	UAUAACUCUGUUAUGCUGA		[6285-6303]
					170	CUGUAAAUAUGAACUCCCA	UGGGAGUUCAUAUUUACAG		[5481-5499]
171	CAAAUUUUUGGAGACUUAA	UUAAGUCUCCAAAAAUUUG		[4278-4296]
					172	GUUUGAGAGUAAAACUGUA	UACAGUUUUACUCUCAAAC		[3337-3355]
173	CGGAUCUUUUCCAUCUAAU	AUUAGAUGGAAAAGAUCCG		[4331-4349]
					174	GGGCCGGAAUCUUAAUAUU	AAUAUUAAGAUUCCGGCCC		[821-839]
175	UGCUGUUAGAGAAAUGAAA	UUUCAUUUCUCUAACAGCA		[5002-5020]
					176	CAUAUUAAAUGACACUUUA	UAAAGUGUCAUUUAAUAUG		[6535-6553]
177	CCAGGACACUUCACUUCCA	UGGAAGUGAAGUGUCCUGG		[3988-4006]

178	AAGUAUUUCUGAUUUUGUA	UACAAAAUCAGAAAUACUU		[2745-2763]
					179	CAAGGAGCAGCUUGCAAGA	UCUUGCAAGCUGCUCCUUG	大鼠，Ms	[968-986]
180	GUACAAAGUUGAAAACUAU	AUAGUUUUCAACUUUGUAC		[470-488]
					181	GACAUAGUUUGAAGGUGAA	UUCACCUUCAAACUAUGUC		[6433-6451]
182	GGGAGCCGCACUUCAUUAA	UUAAUGAAGUGCGGCUCCC		[4087-4105]
					183	UGAUCAUUUGCAAAGUCAA	UUGACUUUGCAAAUGAUCA		[4361-4379]
184	CUGGAAAUUUGGGCUAAAA	UUUUAGCCCAAAUUUCCAG		[5539-5557]
					185	GUGGUGGAAAACUGAAAAA	UUUUUCAGUUUUCCACCAC	大鼠	[736-754]
186	CAAAUCUACUUGUUAAAAA	UUUUUAACAAGUAGAUUUG		[5370-5388]
					187	CAAUAUUCAUUUAACUCAU	AUGAGUUAAAUGAAUAUUG		[1148-1166]
188	CGUACUUGUGCGAAUUAUU	AAUAAUUCGCACAAGUACG		[2152-2170]
					189	AGAUGUGCAUACAUUAUAU	AUAUAAUGUAUGCACAUCU		[7099-7117]
190	UAAUAUGCAUAGAACAAAA	UUUUGUUCUAUGCAUAUUA		[2331-2349]
					191	GUCAGUACAAAGUUGAAAA	UUUUCAACUUUGUACUGAC		[466-484]
192	UGAAGAUGUGCAUACAUUA	UAAUGUAUGCACAUCUUCA		[7096-7114]
					193	GGUUCAGUUUCAAGGACAU	AUGUCCUUGAAACUGAACC		[1276-1294]
194	GGAUCUUUUCCAUCUAAUU	AAUUAGAUGGAAAAGAUCC		[4332-4350]
					195	AGAACAAAAGAUUUGGAAA	UUUCCAAAUCUUUUGUUCU		[2341-2359]
196	GAUUGAAUUCCAUUAGCAU	AUGCUAAUGGAAUUCAAUC		[1703-1721]
					197	CCAUGUUGAGAUUCUCAUA	UAUGAGAAUCUCAACAUGG		[2959-2977]
198	GAAGAAUAGUUGUUUAAAU	AUUUAAACAACUAUUCUUC		[3172-3190]
					199	ACUAAAAGAUCUUUGUUAA	UUAACAAAGAUCUUUUAGU	Ms	[2856-2874]
200	GUACCUGCAGACAUCAAUA	UAUUGAUGUCUGCAGGUAC		[165-183]
					201	ACUGAAUUGUUUUAACAUA	UAUGUUAAAACAAUUCAGU		[4052-4070]
202	CUGCAGACAUCAAUAAGGA	UCCUUAUUGAUGUCUGCAG		[169-187]
					203	UGGGCUAAAACUUAGAAAA	UUUUCUAAGUUUUAGCCCA		[5548-5566]
204	UGUUCAAACGCCUGCAAAA	UUUUGCAGGCGUUUGAACA		[2555-2573]

205	AAAUCUGUAUGGAUAGAAA	UUUCUAUCCAUACAGAUUU	大鼠，Ms	[1480-1498]
					206	CUUUGUGGAUGAAAAAUAU	AUAUUUUUCAUCCACAAAG	Ms	[2673-2691]
207	CGCACUUCAUUAAAAUUCU	AGAAUUUUAAUGAAGUGCG		[4093-4111]
					208	GUUUCAAGGACAUUAAGAA	UUCUUAAUGUCCUUGAAAC		[1282-1300]
209	AGAUACUUCUGAAAUAAAU	AUUUAUUUCAGAAGUAUCU		[3098-3116]
					210	GGACAUCUAGUCACUUGUA	UACAAGUGACUAGAUGUCC		[1524-1542]
211	GAAUAAGAAGCAUCAUACU	AGUAUGAUGCUUCUUAUUC		[1858-1876]
					212	CGUUUUUGUUCCUUGUGGA	UCCACAAGGAACAAAAACG	Ms	[1508-1526]
213	CACAUGAUAUACCCUUUAA	UUAAAGGGUAUAUCAUGUG		[4886-4904]
					214	CCCGAAUCAUUGUUUUAUU	AAUAAAACAAUGAUUCGGG		[4906-4924]
215	UCAUUACUUUCAAGCAAAA	UUUUGCUUGAAAGUAAUGA		[1588-1606]
					216	GUAUCUUCAAAGUAGACAA	UUGUCUACUUUGAAGAUAC		[7608-7626]
217	UCUAGUGAAUGCUCAGAAA	UUUCUGAGCAUUCACUAGA		[1367-1385]
					218	AACUUUCACUACAUAUUAA	UUAAUAUGUAGUGAAAGUU		[6524-6542]
219	UUGGGAACAACAUGCUAAA	UUUAGCAUGUUGUUCCCAA		[1076-1094]
					220	GGAUUGAAUUCCAUUAGCA	UGCUAAUGGAAUUCAAUCC		[1702-1720]
221	CAGGGUAUUAGCUGUAUUA	UAAUACAGCUAAUACCCUG		[1798-1816]
					222	CAAUCAUCAAUGCAUAUAU	AUAUAUGCAUUGAUGAUUG		[6571-6589]
223	CUUGUAUCUUAAAGUUUCA	UGAAACUUUAAGAUACAAG		[2982-3000]
					224	UGCAGACAUCAAUAAGGAA	UUCCUUAUUGAUGUCUGCA		[170-188]
225	AUUGCUUUCUGCUGUAUAA	UUAUACAGCAGAAAGCAAU		[8318-8336]
					226	AAAUAAUGGAGGAAAAAAU	AUUUUUUCCUCCAUUAUUU		[1300-1318]
227	CCAUUUUCUUUUAAAGUUA	UAACUUUAAAAGAAAAUGG		[2127-2145]
					228	UGUUGUGGUGGAAAACUGA	UCAGUUUUCCACCACAACA	大鼠	[732-750]
229	CCAUUUUUCUGGAUUUAGU	ACUAAAUCCAGAAAAAUGG		[8076-8094]
					230	GGAAAGAUGUCAAAGAUAU	AUAUCUUUGACAUCUUUCC		[2244-2262]
231	CAGUAGGGUAUAAACUAGA	UCUAGUUUAUACCCUACUG		[3219-3237]

232	CAGCUUUAGUUUUUCUAAU	AUUAGAAAAACUAAAGCUG		[2586-2604]
					233	UCUUAUUCUGUAUCAUUAA	UUAAUGAUACAGAAUAAGA		[8028-8046]
234	GAUUCAAGUAGUUUUGCAA	UUGCAAAACUACUUGAAUC		[4512-4530]
					235	AGAUUAUAGCUAAUUAGUA	UACUAAUUAGCUAUAAUCU		[6398-6416]
236	GGUUUGUCUUGACCUGGAA	UUCCAGGUCAAGACAAACC		[5526-5544]
					237	AAAGAUAUGUUAAGUGUAA	UUACACUUAACAUAUCUUU		[2255-2273]
238	GUGUACCUGCAGACAUCAA	UUGAUGUCUGCAGGUACAC		[163-181]
					239	CUGUGAGUUCUGAUAGGAA	UUCCUAUCAGAACUCACAG		[856-874]
240	GUGUGAAAAAGGAAUAAAU	AUUUAUUCCUUUUUCACAC		[2042-2060]
					241	UGAUCUAAUUGUAUUAGUA	UACUAAUACAAUUAGAUCA		[8195-8213]
242	GUUGUGGUGGAAAACUGAA	UUCAGUUUUCCACCACAAC	大鼠	[733-751]
					243	CCUCUUGGAAAUUAUAAAA	UUUUAUAAUUUCCAAGAGG		[3138-3156]
244	CAAGGGUUUUAAUGUAAUU	AAUUACAUUAAAACCCUUG		[8124-8142]
					245	GUGCUUUAGUUGUCAUGCA	UGCAUGACAACUAAAGCAC		[314-332]
246	UGGGAUGUAUAUAUAUCAU	AUGAUAUAUAUACAUCCCA		[4983-5001]
					247	UUUUUGAAAGCGUAUUUAA	UUAAAUACGCUUUCAAAAA		[2190-2208]
248	ACAUCUAGUCACUUGUAAA	UUUACAAGUGACUAGAUGU		[1526-1544]
					249	CAGAAUUUUUAGAAAGUAU	AUACUUUCUAAAAAUUCUG		[2512-2530]
250	CGGAAUCUUAAUAUUCGAA	UUCGAAUAUUAAGAUUCCG		[825-843]
					251	AGACAUCAAUAAGGAAGAA	UUCUUCCUUAUUGAUGUCU		[173-191]
252	AUAAUAGGACAAUCAUCAA	UUGAUGAUUGUCCUAUUAU		[6562-6580]
					253	GUGGAAAGAUAGAGAUUGU	ACAAUCUCUAUCUUUCCAC		[2073-2091]
254	CAUGCAGACUAUCUUUUGA	UCAAAAGAUAGUCUGCAUG		[534-552]
					255	AGGACAUUAAGAAAAUAAU	AUUAUUUUCUUAAUGUCCU		[1288-1306]
256	CAGAGAUCAUUUUGCCUUA	UAAGGCAAAAUGAUCUCUG		[497-515]
					257	AAGAAAAUGGGAAGCAAUA	UAUUGCUUCCCAUUUUCUU		[5330-5348]
258	GAUCAAAAGCAUUGUCUUA	UAAGACAAUGCUUUUGAUC		[4568-4586]

259	CAAGGAGACCAUGUAUGUA	UACAUACAUGGUCUCCUUG		[5453-5471]
					260	UCUUAAUAUUCGAAGUGAA	UUCACUUCGAAUAUUAAGA		[830-848]
261	CAUUAGCAUUUGCUACCAA	UUGGUAGCAAAUGCUAAUG		[1713-1731]
					262	GUGUGGAAAACUAAGAAAA	UUUUCUUAGUUUUCCACAC		[8300-8318]
263	UGGUUUUUUUCACUUAGAA	UUCUAAGUGAAAAAAACCA		[8274-8292]
					264	CUGUUCGAAUUUUUUAUAA	UUAUAAAAAAUUCGAACAG		[2473-2491]
265	GUAUAGUCUAGACUUUAAA	UUUAAAGUCUAGACUAUAC		[3916-3934]
					266	GAGGAAUUGAAAACACUGA	UCAGUGUUUUCAAUUCCUC		[6638-6656]
267	GAGUCAAGUCAGACUUCAU	AUGAAGUCUGACUUGACUC	大鼠	[1401-1419]
					268	AGUAAGGCAUGUUACUACA	UGUAGUAACAUGCCUUACU		[3311-3329]
269	AUCUGUGAAAGGAAAAUAA	UUAUUUUCCUUUCACAGAU		[5407-5425]
					270	GAUGUAACAAGGGUUUUAA	UUAAAACCCUUGUUACAUC		[8117-8135]
271	CCAGUUCUUUCAUUUUACA	UGUAAAAUGAAAGAACUGG		[6338-6356]
					272	CAGACAUCAAUAAGGAAGA	UCUUCCUUAUUGAUGUCUG		[172-190]
273	UGUAGUGAGUGUAUAUAAU	AUUAUAUACACUCACUACA		[4721-4739]
					274	AAGAAGGCAGGGCAGUUAA	UUAACUGCCCUGCCUUCUU		[2607-2625]
275	CAGUUUAUUCAUCUGUGAA	UUCACAGAUGAAUAAACUG		[5397-5415]
					276	AAAAACACUUGAAUAAGAA	UUCUUAUUCAAGUGUUUUU		[3199-3217]
277	GACUGAUCUAAUUGUAUUA	UAAUACAAUUAGAUCAGUC		[8192-8210]
					278	GGAAAAUAAUACUUAUCUU	AAGAUAAGUAUUAUUUUCC		[5417-5435]
279	GUGAGUAAGGCAUGUUACU	AGUAACAUGCCUUACUCAC		[3308-3326]
					280	GUCAAAUCUACUUGUUAAA	UUUAACAAGUAGAUUUGAC		[5368-5386]
281	CAUGGAAAGAUGUCAAAGA	UCUUUGACAUCUUUCCAUG		[2241-2259]
					282	CAGCAUUAGUUUCACAUGA	UCAUGUGAAACUAAUGCUG		[4874-4892]
283	UGGUUUUAGCAUUUACAAA	UUUGUAAAUGCUAAAACCA		[4599-4617]
					284	UAAAGUUCCUGCUGUAAAU	AUUUACAGCAGGAACUUUA		[5470-5488]
285	GGAGGAGGGCUAACUGAUU	AAUCAGUUAGCCCUCCUCC		[1038-1056]

286	GACUGAAUUGUUUUAACAU	AUGUUAAAACAAUUCAGUC		[4051-4069]
					287	UGUGAAAUUUAAUGCACAA	UUGUGCAUUAAAUUUCACA		[4168-4186]
288	CUAAAUUCCAGUUAAUUAA	UUAAUUAACUGGAAUUUAG		[4618-4636]
					289	CAAGGACUGAAUUGUUUUA	UAAAACAAUUCAGUCCUUG		[4047-4065]
290	GUAGUAGAUACUUCUGAAA	UUUCAGAAGUAUCUACUAC		[3093-3111]
					291	UGUCUUAUCUUGUUUCAAA	UUUGAAACAAGAUAAGACA		[2724-2742]
292	UCUGAUUUUGUAAAAUGAA	UUCAUUUUACAAAAUCAGA	Ms	[2752-2770]
					293	CUGGUGGAAAGAUAGAGAU	AUCUCUAUCUUUCCACCAG		[2070-2088]
294	UCAGAAAGACAGUAUGCAA	UUGCAUACUGUCUUUCUGA		[1379-1397]
					295	GGUCAGUACAAAGUUGAAA	UUUCAACUUUGUACUGACC		[465-483]
296	AGUCCUAUUUUCAAGAGAA	UUCUCUUGAAAAUAGGACU		[109-127]
					297	CAAUGUGAAAUGUAAAUGA	UCAUUUACAUUUCACAUUG		[2638-2656]
298	AGAAGAGUUUAAUAGAUUA	UAAUCUAUUAAACUCUUCU	大鼠，Ms	[200-218]
					299	GUUUCUUUAUACUGGUGAA	UUCACCAGUAUAAAGAAAC		[281-299]
300	GUGCUUUUGUUGUGGUGGA	UCCACCACAACAAAAGCAC		[725-743]
					301	AGUAUUUUGCUGAUUUAAA	UUUAAAUCAGCAAAAUACU		[2526-2544]
302	CACUGUACCAUAACUUUCA	UGAAAGUUAUGGUACAGUG		[6513-6531]
					303	UGUUGCUUCAGGUUCUUAA	UUAAGAACCUGAAGCAACA		[4233-4251]
304	GAAUCAGUAGGGUAUAAAC	GUUUAUACCCUACUGAUUC		[3215-3233]
					305	UAGGAAUUUCCCAAAUUCA	UGAAUUUGGGAAAUUCCUA	大鼠，Ms	[869-887]
306	CUUAUUUUUCUGUGAAUAA	UUAUUCACAGAAAAAUAAG	Ms	[8361-8379]
					307	CAUCUAAUUCCGCAAAAAU	AUUUUUGCGGAAUUAGAUG		[4342-4360]
308	CAAAUGUUUAUGUUUUCAA	UUGAAAACAUAAACAUUUG		[6484-6502]
					309	GAAGAGUUUAAUAGAUUAA	UUAAUCUAUUAAACUCUUC	大鼠，Ms	[201-219]
310	UUUUGAAAGCGUAUUUAAU	AUUAAAUACGCUUUCAAAA		[2191-2209]
					311	GAGUGUAUAUAAUGUGAUU	AAUCACAUUAUAUACACUC		[4727-4745]
312	GAGUGUCUGGUAAGAACUA	UAGUUCUUACCAGACACUC		[1176-1194]

313	AAGACAGUAUGCAAGAUGA	UCAUCUUGCAUACUGUCUU		[1384-1402]
					314	GGAUGAAAAAUAUUUCUGA	UCAGAAAUAUUUUUCAUCC	Ms	[2679-2697]
315	AAAGAUUAUUCUUCUCAAA	UUUGAGAAGAAUAAUCUUU		[6169-6187]
					316	GAGCUUUCUGUAUAUAAAU	AUUUAUAUACAGAAAGCUC		[1981-1999]
317	UGGAAAGAUAUACACCAAA	UUUGGUGUAUAUCUUUCCA		[2354-2372]
					318	GACAUCUAGUCACUUGUAA	UUACAAGUGACUAGAUGUC		[1525-1543]
319	GUCAAACCCUUAAAAAUAU	AUAUUUUUAAGGGUUUGAC		[6130-6148]
					320	CCAAAAUCCUAUGGUACAA	UUGUACCAUAGGAUUUUGG		[1241-1259]
321	GACACUUUAUAACUAAUAU	AUAUUAGUUAUAAAGUGUC		[6545-6563]
					322	AAAAAACACUUGAAUAAGA	UCUUAUUCAAGUGUUUUUU		[3198-3216]
323	AAAAGAUUUGGAAAGAUAU	AUAUCUUUCCAAAUCUUUU		[2346-2364]
					324	GUCAUUACUUUCAAGCAAA	UUUGCUUGAAAGUAAUGAC		[1587-1605]
325	AGAGUACUAUAUUUGUGAA	UUCACAAAUAUAGUACUCU		[8245-8263]
					326	GGUGCAAAUAUCUGUUAGA	UCUAACAGAUAUUUGCACC		[1105-1123]
327	UUGGAAAGAUAUACACCAA	UUGGUGUAUAUCUUUCCAA		[2353-2371]
					328	UGCUUUUGUUGUGGUGGAA	UUCCACCACAACAAAAGCA	大鼠	[726-744]
329	UGAAUUUCUUGAUUUUUCA	UGAAAAAUCAAGAAAUUCA		[1781-1799]
					330	AGUACAAAGUUGAAAACUA	UAGUUUUCAACUUUGUACU		[469-487]
331	AGUUGAGCUUUCUAAGAGA	UCUCUUAGAAAGCUCAACU		[6191-6209]
					332	UUAUGUAGGUAAAAGUAGA	UCUACUUUUACCUACAUAA		[2900-2918]
333	UAGGUCAAACCCUUAAAAA	UUUUUAAGGGUUUGACCUA		[6127-6145]
					334	AACCAUAGACUAAGAAUAA	UUAUUCUUAGUCUAUGGUU		[1845-1863]
335	CAUAGUAUACUGAUUUAAU	AUUAAAUCAGUAUACUAUG		[1899-1917]
					336	UGUGGAGAUUAGAGUUAAU	AUUAACUCUAAUCUCCACA		[1999-2017]
337	CUAAGAAUAAGAAGCAUCA	UGAUGCUUCUUAUUCUUAG		[1854-1872]
					338	UGGUAUCCAGGGUGCAAAU	AUUUGCACCCUGGAUACCA		[1095-1113]
339	GGAGUUUACCACUUUCUUA	UAAGAAAGUGGUAAACUCC		[8014-8032]

340	UAUCAUUGCUGUUAGAGAA	UUCUCUAACAGCAAUGAUA		[4996-5014]
					341	UGGAGACUCAGCAGUUGGA	UCCAACUGCUGAGUCUCCA		[353-371]
342	UAGUCAUGCAAAGAUUCAA	UUGAAUCUUUGCAUGACUA		[4500-4518]
					343	GUGAACUGACUUUAAGUAA	UUACUUAAAGUCAGUUCAC		[1680-1698]
344	AGGGACAAGAAUAUAUAAA	UUUAUAUAUUCUUGUCCCU	大鼠	[1129-1147]
					345	AAGAAUCAGUAGGGUAUAA	UUAUACCCUACUGAUUCUU		[3213-3231]
346	UAGAUACUUCUGAAAUAAA	UUUAUUUCAGAAGUAUCUA		[3097-3115]
					347	GGCUUUUUCCCACUUCAAU	AUUGAAGUGGGAAAAAGCC		[6217-6235]
348	CUUGUAUGUUUAGAGUUAA	UUAACUCUAAACAUACAAG		[4119-4137]
					349	CAUGUUACUACAGAGGAAA	UUUCCUCUGUAGUAACAUG		[3318-3336]
350	CAGAAGGGACAAGAAUAUA	UAUAUUCUUGUCCCUUCUG		[1125-1143]
					351	GUUUCUCAUAGAUAAGAUA	UAUCUUAUCUAUGAGAAAC		[5612-5630]
352	CUUUUAUCUUGAAAAUAGU	ACUAUUUUCAAGAUAAAAG		[413-431]
					353	GCUUGUAGUUAUAGUGACA	UGUCACUAUAACUACAAGC		[2935-2953]
354	GCAAUUAUUUUUAAACCAA	UUGGUUUAAAAAUAAUUGC		[6803-6821]
					355	UGAUGAUACCAUCUUCCAA	UUGGAAGAUGGUAUCAUCA		[1226-1244]
356	GAGACAGAGUACUAUAUUU	AAAUAUAGUACUCUGUCUC		[8240-8258]
					357	CCGCAAAAAUUGAUCAUUU	AAAUGAUCAAUUUUUGCGG		[4351-4369]
358	UCAGUUUCAAGGACAUUAA	UUAAUGUCCUUGAAACUGA		[1279-1297]
					359	AAAGCAUUGUCUUAAUUUU	AAAAUUAAGACAAUGCUUU		[4573-4591]
360	AAGAAGCAUCAUACUAUAA	UUAUAGUAUGAUGCUUCUU		[1862-1880]
					361	GAAGAUGUGCAUACAUUAU	AUAAUGUAUGCACAUCUUC		[7097-7115]
362	AGCCGCACUUCAUUAAAAU	AUUUUAAUGAAGUGCGGCU		[4090-4108]
					363	AGCUCAAGGAGACCAUGUA	UACAUGGUCUCCUUGAGCU		[5449-5467]
364	GAAAGAUAGAGAUUGUUUU	AAAACAAUCUCUAUCUUUC		[2076-2094]
					365	AGUAGUUUUGCAAUAAGUA	UACUUAUUGCAAAACUACU		[4518-4536]
366	GGUGUUUCUCAUAGAUAAG	CUUAUCUAUGAGAAACACC		[5609-5627]

367	UGUGGAAAACUAAGAAAAU	AUUUUCUUAGUUUUCCACA		[8301-8319]
					368	GAUCUUUGUUAACUCAGUA	UACUGAGUUAACAAAGAUC		[2863-2881]
369	AGAAAAAAUUCUUACAUGA	UCAUGUAAGAAUUUUUUCU		[5561-5579]
					370	UCUAGUCACUUGUAAACAA	UUGUUUACAAGUGACUAGA		[1529-1547]
371	AAAAGAUUAUUCUUCUCAA	UUGAGAAGAAUAAUCUUUU		[6168-6186]
					372	UGGUCAGAUUCUACUUUGA	UCAAAGUAGAAUCUGACCA		[7962-7980]
373	GUUCCAUGCUGGUGGAAAG	CUUUCCACCAGCAUGGAAC		[2062-2080]
					374	GAAAGCGUAUUUAAUGAUA	UAUCAUUAAAUACGCUUUC		[2195-2213]
375	CCAAAUUGCAGAUUUAUCA	UGAUAAAUCUGCAAUUUGG	大鼠，Ms	[390-408]
					376	CUAAGUCACUUUACUAAAA	UUUUAGUAAAGUGACUUAG	Ms	[2844-2862]
377	CAAAGAUAUGUUAAGUGUA	UACACUUAACAUAUCUUUG		[2254-2272]
					378	GAGACUCAAAGGUGAUGUA	UACAUCACCUUUGAGUCUC		[6369-6387]
379	AAAUGACACUUUAUAACUA	UAGUUAUAAAGUGUCAUUU		[6541-6559]
					380	UGAGGCAACUGAGACUCAA	UUGAGUCUCAGUUGCCUCA		[6359-6377]
381	AUAGUUUGAAGGUGAAAAA	UUUUUCACCUUCAAACUAU		[6436-6454]
					382	GAGGAGUGUCUGGUAAGAA	UUCUUACCAGACACUCCUC		[1173-1191]
383	GUCUUAAUCUAACUCUAUA	UAUAGAGUUAGAUUAAGAC		[1616-1634]
					384	GUAGGAAAAAAAAUGUACA	UGUACAUUUUUUUUCCUAC		[1732-1750]
385	UGAUGAAGAUGUGCAUACA	UGUAUGCACAUCUUCAUCA		[7093-7111]
					386	CAAAUUCUGGUAUCCAGAA	UUCUGGAUACCAGAAUUUG		[445-463]
387	AUUGUAUCUUCAAAGUAGA	UCUACUUUGAAGAUACAAU		[7605-7623]
					388	GCUACCAAGUAGGAAAAAA	UUUUUUCCUACUUGGUAGC		[1724-1742]
389	AUAGGUCAAACCCUUAAAA	UUUUAAGGGUUUGACCUAU		[6126-6144]
					390	ACCUCUUGGAAAUUAUAAA	UUUAUAAUUUCCAAGAGGU		[3137-3155]
391	GUUUGAAGGUGAAAAACUU	AAGUUUUUCACCUUCAAAC		[6439-6457]
					392	UGUAUAGUCUAGACUUUAA	UUAAAGUCUAGACUAUACA		[3915-3933]
393	GCUUUUUCCCACUUCAAUA	UAUUGAAGUGGGAAAAAGC		[6218-6236]

394	AUUCAUCUGUGAAAGGAAA	UUUCCUUUCACAGAUGAAU		[5403-5421]
					395	GGCAGUUAACCUUUUUGGU	ACCAAAAAGGUUAACUGCC		[2617-2635]
396	CAGUAUGCAAGAUGAGUCA	UGACUCAUCUUGCAUACUG		[1388-1406]
					397	CCUUGGGAACAACAUGCUA	UAGCAUGUUGUUCCCAAGG		[1074-1092]
398	UGAGAGUAAAACUGUAAAA	UUUUACAGUUUUACUCUCA		[3340-3358]
					399	GAUGUGAACUGACUUUAAG	CUUAAAGUCAGUUCACAUC		[1677-1695]
400	CUAUUGUAGAGGUGAGUAA	UUACUCACCUCUACAAUAG		[3297-3315]
					401	AAGAGGAGAAGCUUUGCAA	UUGCAAAGCUUCUCCUCUU	大鼠，Ms	[1462-1480]
402	GAAUUUCCCAAAUUCAACA	UGUUGAAUUUGGGAAAUUC	大鼠，Ms	[872-890]
					403	GGUUGCAAGAGCUCAAGGA	UCCUUGAGCUCUUGCAACC		[5440-5458]
404	GUCUGCUGAUCAAAAGCAU	AUGCUUUUGAUCAGCAGAC		[4561-4579]
					405	ACAGGUGAGGCAACUGAGA	UCUCAGUUGCCUCACCUGU		[6354-6372]
406	GAGAGUAAAACUGUAAAAA	UUUUUACAGUUUUACUCUC		[3341-3359]
					407	UUAGCAUUUACAAACUAAA	UUUAGUUUGUAAAUGCUAA		[4604-4622]
408	GAUUAAGAUGUAUAUAGGA	UCCUAUAUACAUCUUAAUC		[3023-3041]
					409	CAAAUUGCAGAUUUAUCAA	UUGAUAAAUCUGCAAUUUG	大鼠，Ms	[391-409]
410	UUCAGAUAGGCUUAACAAA	UUUGUUAAGCCUAUCUGAA		[1960-1978]
					411	GCUCAAGGAGACCAUGUAU	AUACAUGGUCUCCUUGAGC		[5450-5468]
412	AAGAUAUGUUAAGUGUAAA	UUUACACUUAACAUAUCUU		[2256-2274]
					413	UCAAAAGCAUUGUCUUAAU	AUUAAGACAAUGCUUUUGA		[4570-4588]
414	GCGUAUUUAAUGAUAGAAU	AUUCUAUCAUUAAAUACGC		[2199-2217]
					415	GUAGAAGCAUGUUUGUACA	UGUACAAACAUGCUUCUAC		[2914-2932]
416	AGUCAGGUAGGUAGUUCAA	UUGAACUACCUACCUGACU		[4007-4025]
					417	GGUAGUUUUUUGACAGGUA	UACCUGUCAAAAAACUACC		[2700-2718]
418	GUCCAGGGUUUACAUUACA	UGUAAUGUAAACCCUGGAC		[3261-3279]
					419	UCCAGAAUGGUCAGUACAA	UUGUACUGACCAUUCUGGA		[457-475]
420	GUGCAAAUAUCUGUUAGAA	UUCUAACAGAUAUUUGCAC		[1106-1124]

421	GUAAUUUGUGCAAAGAUUA	UAAUCUUUGCACAAAUUAC		[6385-6403]
					422	AGUAAGGAUUCAUCCUUAA	UUAAGGAUGAAUCCUUACU		[2804-2822]
423	GACUCAAAGGUGAUGUAAU	AUUACAUCACCUUUGAGUC		[6371-6389]
					424	GAAAUAAAUGUUCUCUCAA	UUGAGAGAACAUUUAUUUC		[3108-3126]
425	CCAAGCUACCUUUCUUGAA	UUCAAGAAAGGUAGCUUGG		[6460-6478]
					426	UGCAAAGAUUAUAGCUAAU	AUUAGCUAUAAUCUUUGCA		[6393-6411]
427	AGAUUUGGAAAGAUAUACA	UGUAUAUCUUUCCAAAUCU		[2349-2367]
					428	UUGUGGUGGAAAACUGAAA	UUUCAGUUUUCCACCACAA	大鼠	[734-752]
429	CAUGCUAAAUGGUAUCCAG	CUGGAUACCAUUUAGCAUG		[1086-1104]
					430	GAUUUAAUUUCUAAGUGUA	UACACUUAGAAAUUAAAUC		[1910-1928]
431	GAUGAUACCAUCUUCCAAA	UUUGGAAGAUGGUAUCAUC		[1227-1245]
					432	AGUCUAGACUUUAAAUUUA	UAAAUUUAAAGUCUAGACU		[3920-3938]
433	GUUCACUCUAGGAUUUCAA	UUGAAAUCCUAGAGUGAAC		[4460-4478]
					434	CAGGGCAGUUAACCUUUUU	AAAAAGGUUAACUGCCCUG		[2614-2632]
435	CCAUGGAUUCAACCAAGGA	UCCUUGGUUGAAUCCAUGG		[6621-6639]
					436	GUUCCUGCUGUAAAUAUGA	UCAUAUUUACAGCAGGAAC		[5474-5492]
437	UCCAGGGUUUACAUUACAA	UUGUAAUGUAAACCCUGGA		[3262-3280]
					438	CUAAGUGUAAGUGAAUUAA	UUAAUUCACUUACACUUAG		[1920-1938]
439	CUUCCAAAAUCCUAUGGUA	UACCAUAGGAUUUUGGAAG		[1238-1256]
					440	UCAUUUAAAACAUUGCAAA	UUUGCAAUGUUUUAAAUGA		[3442-3460]
441	GAAAGGUCCAAAUGUUUAU	AUAAACAUUUGGACCUUUC		[6476-6494]
					442	GCAGACUAUCUUUUGAGAA	UUCUCAAAAGAUAGUCUGC		[537-555]
443	AGCAUAACAGAGUUAUAGA	UCUAUAACUCUGUUAUGCU		[6287-6305]
					444	GUCAGCUUAUGUAGGUAAA	UUUACCUACAUAAGCUGAC		[2894-2912]
445	CCAUGUAUGUAAAGUUCCU	AGGAACUUUACAUACAUGG		[5461-5479]
					446	AAUAGGUCAAACCCUUAAA	UUUAAGGGUUUGACCUAUU		[6125-6143]
447	AUUUCUAAGUGUAAGUGAA	UUCACUUACACUUAGAAAU		[1916-1934]

448	UAUGGUACAAGAAGCUAUA	UAUAGCUUCUUGUACCAUA		[1250-1268]
					449	GGCUAACAAGUUUAUUUUA	UAAAAUAAACUUGUUAGCC	Ms	[4196-4214]
450	GUGAGUGUAUAUAAUGUGA	UCACAUUAUAUACACUCAC		[4725-4743]
					451	AUAUAGUCAUUAACUUGAA	UUCAAGUUAAUGACUAUAU		[3889-3907]
452	UGUUAACUCAGUAUUUUAA	UUAAAAUACUGAGUUAACA		[2869-2887]
					453	UUGCAAAGUCAAAACUAUA	UAUAGUUUUGACUUUGCAA		[4368-4386]
454	UGGAGCUUUCUGUAUAUAA	UUAUAUACAGAAAGCUCCA		[1979-1997]
					455	GGCUUUUCCUGUUCUGGGA	UCCCAGAACAGGAAAAGCC		[4072-4090]
456	CAUGUUAUGUUGUUCUUAU	AUAAGAACAACAUAACAUG		[1640-1658]
					457	UUCUGGAUUUAGUAAGAAA	UUUCUUACUAAAUCCAGAA		[8082-8100]
458	GGCUUUUAUCUUGAAAAUA	UAUUUUCAAGAUAAAAGCC		[411-429]
					459	GCUUUUGUUGUGGUGGAAA	UUUCCACCACAACAAAAGC	大鼠	[727-745]
460	GAACAGAAGGGACAAGAAU	AUUCUUGUCCCUUCUGUUC		[1122-1140]
					461	GCAAAUAUCUGUUAGAACA	UGUUCUAACAGAUAUUUGC		[1108-1126]
462	UUGGUUAUAUAGUCAUUAA	UUAAUGACUAUAUAACCAA		[3883-3901]
					463	AGGAGGAAUUGAAAACACU	AGUGUUUUCAAUUCCUCCU		[6636-6654]
464	AGCUUAUUUUUCUGUGAAU	AUUCACAGAAAAAUAAGCU	Ms	[8359-8377]
					465	AGACUUCAUUACAGAAAGA	UCUUUCUGUAAUGAAGUCU		[1411-1429]
466	GCAAUAUAAUCUUUGAAUU	AAUUCAAAGAUUAUAUUGC		[1768-1786]
					467	AAUUUAGUCUGCUGAUCAA	UUGAUCAGCAGACUAAAUU		[4555-4573]
468	UAAGGAAGAAGAAUUUGUA	UACAAAUUCUUCUUCCUUA		[182-200]
					469	GUUAACUCAGUAUUUUAAA	UUUAAAAUACUGAGUUAAC		[2870-2888]
470	UAUUCAUCUGUGAAAGGAA	UUCCUUUCACAGAUGAAUA		[5402-5420]
					471	GAUUAAAAACUUUUGCUAA	UUAGCAAAAGUUUUUAAUC		[214-232]
472	GAUUCUACUUUGAAUCUGA	UCAGAUUCAAAGUAGAAUC		[7968-7986]
					473	AAGGAGACCAUGUAUGUAA	UUACAUACAUGGUCUCCUU		[5454-5472]
474	AGUCAGACUUCAUUACAGA	UCUGUAAUGAAGUCUGACU		[1407-1425]

475	AAUGACACUUUAUAACUAA	UUAGUUAUAAAGUGUCAUU		[6542-6560]
					476	GUCAGACUUCAUUACAGAA	UUCUGUAAUGAAGUCUGAC		[1408-1426]
477	CACGUACUUGUGCGAAUUA	UAAUUCGCACAAGUACGUG		[2150-2168]
					478	CUGACUGACUGAUCUAAUU	AAUUAGAUCAGUCAGUCAG		[8186-8204]
479	AAAAUAAUGGAGGAAAAAA	UUUUUUCCUCCAUUAUUUU		[1299-1317]
					480	UUACCGUUAGGAUGAUUAA	UUAAUCAUCCUAACGGUAA		[3010-3028]
481	AUAUGAACUCCCAUCCUAA	UUAGGAUGGGAGUUCAUAU		[5487-5505]
					482	AGUCCUGUUUCAGCAUCAA	UUGAUGCUGAAACAGGACU	大鼠，Ms	[246-264]
483	CAUCCAUGGAUUCAACCAA	UUGGUUGAAUCCAUGGAUG		[6618-6636]
					484	GUAUGUUUAGAGUUAAGCA	UGCUUAACUCUAAACAUAC		[4122-4140]
485	UAAUCAUCUGGAUUUUUUA	UAAAAAAUCCAGAUGAUUA		[1936-1954]
					486	UCUCAGAUCUUCCAAUUAA	UUAAUUGGAAGAUCUGAGA	Ms	[2783-2801]
487	GGUUGCAGAUCUAGUGAAU	AUUCACUAGAUCUGCAACC		[1358-1376]
					488	GCACUUCAUUAAAAUUCUU	AAGAAUUUUAAUGAAGUGC		[4094-4112]
489	UUAGGAUGAUUAAGAUGUA	UACAUCUUAAUCAUCCUAA		[3016-3034]
					490	GAUGAAGAUGUGCAUACAU	AUGUAUGCACAUCUUCAUC		[7094-7112]
491	GGCAAUAUAAUCUUUGAAU	AUUCAAAGAUUAUAUUGCC		[1767-1785]
					492	GAAAGAGUAUUGUUAUGUU	AACAUAACAAUACUCUUUC		[3387-3405]
493	GUAAAGUUCCUGCUGUAAA	UUUACAGCAGGAACUUUAC		[5469-5487]
					494	GUAUGUAUUACUUUUGUAA	UUACAAAAGUAAUACAUAC		[2492-2510]
495	GCUAAUUUUCCAAGUGGUA	UACCACUUGGAAAAUUAGC		[228-246]
					496	UGAACUGACUUUAAGUAAU	AUUACUUAAAGUCAGUUCA		[1681-1699]
497	CCAUAGACUAAGAAUAAGA	UCUUAUUCUUAGUCUAUGG		[1847-1865]
					498	GUGAAGAAGCUAGAUUAAA	UUUAAUCUAGCUUCUUCAC		[613-631]
499	ACAGGUAGACCAUGUCUUA	UAAGACAUGGUCUACCUGU		[2712-2730]
					500	GCUUAUUUUUCUGUGAAUA	UAUUCACAGAAAAAUAAGC	Ms	[8360-8378]

Claims (73)

1.一种抑制受试者视网膜神经节细胞缺失的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合包含治疗有效量的至少一种siRNA，所述siRNA下调与视网膜神经节细胞缺失相关的目标基因表达，从而抑制所述受试者视网膜神经节细胞的缺失。

2.根据权利要求1所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

3.根据权利要求1或2所述的方法，其中所述受试者是人类。

4.根据权利要求1至3任一所述的方法，其中所述受试者是患有眼部疾病、眼部障碍或眼部损伤、或存在发展眼部疾病、眼部障碍或眼部损伤的风险。

5.根据权利要求1至4任一所述的方法，其中所述视网膜神经节细胞的缺失与受试者的眼部疾病、眼部障碍或眼部损伤有关。

6.根据权利要求4或5所述的方法，其中所述眼部疾病、眼部障碍或眼部损伤包括神经变性。

7.根据权利要求1至6任一所述的方法，其中所述眼科组合物被配制为霜、泡沫、膏、软膏、乳剂、液体溶液、滴眼剂、凝胶、喷雾、悬浮液、微乳液、微球、微囊剂、纳米球、纳米粒子、脂质囊泡、脂质体、聚合物囊泡、眼罩或隐形眼镜。

8.根据权利要求7所述的方法，其中所述眼科组合物被配制为滴眼剂。

9.根据权利要求4至8任一所述的方法，其中所述疾病、障碍或损伤是选自由青光眼、干眼症、糖尿病视网膜病变(DR)、糖尿病性黄斑水肿(DME)、老年性黄斑变性(AMD)、视神经炎、视网膜中央静脉阻塞、视网膜分枝静脉阻塞、缺血性视神经病变、视神经损伤、早产儿视网膜病变(ROP)或色素性视网膜炎(RP)、视网膜神经节细胞变性、黄斑变性、遗传性视神经病变、代谢性视神经病变，以及由于毒剂或药物不良反应或维生素缺乏症引起的神经病变组成的组。

10.根据权利要求9所述的方法，其中所述疾病、障碍或损伤是青光眼，所述目标基因如SEQ ID NO：1-35任一所述。

11.根据权利要求10所述的方法，其中所述目标基因如SEQ IDNO：1-2、SEQ ID NO：4、SEQ ID NO：6-7、SEQ ID NO：12，SEQ IDNO：14、SEQ ID NO：19-20、SEQ ID NO：21和SEQ ID NO：28-29任一所述。

12.根据权利要求11所述的方法，其中所述目标基因如SEQ IDNO：1-SEQ ID NO：2任一所述。

13.根据权利要求9所述的方法，其中所述疾病、障碍或损伤是干眼症，所述目标基因如SEQ IDNO：5、SEQ ID NO：8-10、SEQ IDNO：26-27和SEQ ID NO：30-44任一所述。

14.根据权利要求13所述的方法，其中所述目标基因如SEQ IDNO：36-SEQ ID NO：44任一所述。

15.根据权利要求9所述的方法，其中所述疾病、障碍或损伤是黄斑变性，所述目标基因如SEQ ID NO：1-3、SEQ ID NO：5-10、SEQID NO：12-13、SEQ ID NO：24-27、SEQ ID NO：30-35、SEQ IDNO：45-53任一所述。

16.根据权利要求15所述的方法，其中所述目标基因如SEQ IDNO：3、SEQ ID NO：12和SEQ ID NO：47任一所述。

17.根据权利要求9所述的方法，其中所述疾病、障碍或损伤是糖尿病性黄斑水肿，所述目标基因如SEQ ID NO：1-3、SEQ IDNO：5-10、SEQ ID NO：12-13、SEQ ID NO：24-27、SEQ ID NO：30-35、SEQ ID NO：45-53任一所述。

18.根据权利要求17所述的方法，其中所述目标基因如SEQ IDNO：3、SEQ ID NO：12和SEQ ID NO：47任一所述。

19.根据权利要求9所述的方法，其中所述疾病、障碍或损伤是糖尿病视网膜病变(DR)，所述目标基因如SEQ ID NO：1-3、SEQ IDNO：5-10、SEQ ID NO：12-13、SEQ ID NO：24-27、SEQ ID NO：30-35、SEQ ID NO：45-53任一所述。

20.根据权利要求19所述的方法，其中所述目标基因如SEQ IDNO：48-53任一所述。

21.根据权利要求9所述的方法，其中所述疾病、障碍或损伤是视网膜色素变性(RP)，所述目标基因如SEQ ID NO：3、SEQ IDNO：14、SEQ ID NO：26-35和SEQ ID NO：54-58任一所述。

22.根据权利要求21所述的方法，其中所述目标基因如SEQ IDNO：56-57任一所述。

23.一种拯救受试者视网膜神经节细胞的细胞凋亡的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至所述受试者的视网膜的目标基因的治疗有效量的至少一种siRNA，从而拯救所述受试者视网膜神经节细胞的细胞凋亡。

24.根据权利要求23所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

25.一种提高呈现视神经病变体征或症状的受试者视网膜神经节细胞存活的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至提高视网膜神经节细胞的存活的目标基因的治疗有效量的至少一种siRNA，从而提高所述受试者视网膜神经节细胞的存活。

26.根据权利要求25所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

27.根据权利要求25或26所述的方法，其中所述体征或症状是细胞凋亡介导的。

28.一种预防、治疗或减轻与受试者视网膜神经节细胞死亡相关的眼部疾病的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至与所述眼部疾病相关的目标基因的治疗有效量的至少一种siRNA，从而预防、治疗或减轻与所述受试者视网膜神经节细胞死亡相关的眼部疾病。

29.根据权利要求28所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

30.一种治疗或预防受试者视网膜神经节细胞死亡的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含：(a)至与所述视网膜神经节细胞死亡相关的目标基因的治疗有效量的至少一种siRNA，和(b)药学上可接受的赋形剂或载体或其混合物，从而治疗或预防所述受试者视网膜神经节细胞死亡。

31.根据权利要求30所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

32.一种预防由于受试者眼中眼内压(IOP)升高介导的视网膜神经节细胞死亡的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合包含至受试者视网膜的目标基因的治疗有效量的至少一种siRNA，从而预防所述受试者视网膜神经节细胞死亡。

33.根据权利要求32所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

34.一种延迟、预防或拯救患有高IOP受试者的视网膜细胞死亡的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至与受试者视网膜中RGC死亡相关的目标基因的治疗有效量的至少一种siRNA，从而延迟、预防或拯救视网膜细胞的损伤或死亡，其中眼内压(IOP)保持基本上升高。

35.根据权利要求34所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

36.根据权利要求32至35任一所述的方法，其中所述受试者是患有青光眼。

37.一种治疗患有视网膜神经节细胞缺失或损伤的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至与所述视网膜神经节细胞缺失或损伤相关的目标基因的治疗有效量的至少一种siRNA，从而治疗所述受试者或降低所述受试者视网膜细胞的死亡。

38.根据权利要求37所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

39.一种减弱视网膜神经节细胞缺失和提供给所需受试者神经保护的方法，包括向受试者眼睛表面局部施用眼科组合物，所述眼科组合物包含至视网膜神经节细胞缺失相关的目标基因的治疗有效量的至少一种siRNA，从而减弱视网膜神经节细胞缺失和提供给所述受试者神经保护。

40.根据权利要求39所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

41.一种预防与受试者视网膜神经节细胞缺失相关的视野丧失的方法，包括无创伤性地向受试者眼睛表面施用眼科组合物，所述眼科组合物包含至受试者视网膜目标基因的治疗有效量的至少一种siRNA，从而预防所述受试者的视野丧失。

42.根据权利要求41所述的方法，其中所述目标基因如SEQ IDNO：1-58任一所述。

43.一种无创伤性治疗与受试者视网膜神经节细胞缺失相关的眼部疾病的眼科组合物，包含：(a)至与眼部疾病相关的目标基因的治疗有效量的至少一种siRNA，和(b)药学上可接受的赋形剂或载体或其混合物。

44.一种无创伤治疗与视觉系统组织的病理性异常/变化有关的眼部疾病的局部眼科药物组合物，包含：(a)至与眼部疾病相关的目标基因的治疗有效量的至少一种siRNA，其中所述目标基因是SEQ IDNO：1-58所述的任一序列，和(b)药学上可接受的赋形剂或载体或其混合物。

45.根据权利要求44所述的组合物，其中所述眼部疾病与视觉系统中的视网膜神经节细胞缺失相关。

46.一种用于治疗受试者患有与视网膜神经节细胞死亡相关的眼部疾病的局部眼科药物组合物，包含：(a)至与眼部疾病相关的目标基因的治疗有效量的至少一种siRNA，其中所述目标基因是SEQ IDNO：1-58所述的任一序列，和(b)药学上可接受的赋形剂或载体或其混合物

47.根据权利要求43至46任一所述的组合物，其中所述siRNA最终存在浓度按组合物体积计为约5μg/μl至约60μg/μl。

48.根据权利要求47所述的组合物，其中所述siRNA最终存在浓度按组合物体积计为约6.6μg/μl。

49.根据权利要求47所述的组合物，其中所述siRNA最终存在浓度按组合物体积计为约25μg/μl。

50.根据权利要求47所述的组合物，其中所述siRNA最终存在浓度按组合物体积计为约33.3μg/μl。

51.根据权利要求47所述的组合物，其中所述siRNA最终存在浓度按组合物体积计为约50μg/μl。

52.根据权利要求43至51任一所述的组合物，其中所述疾病是选自由青光眼、干眼症、糖尿病视网膜病变(DR)、糖尿病性黄斑水肿(DME)、老年性黄斑变性(AMD)、视神经炎、视网膜中央静脉阻塞、视网膜分枝静脉阻塞、缺血性视神经病变、视神经损伤、早产儿视网膜病变(ROP)或色素性视网膜炎(RP)、视网膜神经节细胞变性，黄斑变性、遗传性视神经病变、代谢性视神经病变，以及由于毒剂或药物不良反应或维生素缺乏症引起的神经病变组成的组。

53.根据权利要求43至52任一所述的组合物，其中所述组合物被配制为霜、泡沫、膏、软膏、乳剂、液体溶液、滴眼剂、凝胶、喷雾、悬浮液、微乳液、微球、微囊剂、纳米球、纳米粒子、脂质囊泡、脂质体、聚合物囊泡、眼罩或隐形眼镜。

54.根据权利要求53所述的方法，其中所述组合物被配制为滴眼剂。

55.一种包装的药物制剂，包括(a)容器内根据权利要求43至54任一所述的药物组合物，(b)所述组合物用于治疗眼部疾病的说明书。

56.根据权利要求43至54任一所述的药物组合物在制备提高视网膜神经节细胞的存活的药物中的用途。

57.一种治疗需要治疗受试者青光眼的方法，所述方法包括局部向受试者眼睛表面施用至受试者眼睛目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如SEQ ID NO：1-35任一所述。

58.根据权利要求57所述的方法，其中所述目标基因如SEQ IDNO：1-2、SEQ ID NO：4、SEQ ID NO：6-7、SEQ ID NO：12、SEQ IDNO：14、SEQ ID NO：19-20、SEQ ID NO：21和SEQ ID NO：28-29任一所述。

59.根据权利要求58所述的方法，其中所述目标基因如SEQ IDNO：1-SEQ ID NO：2任一所述。

60.一种治疗需要治疗受试者干眼症的方法，所述方法包括局部向受试者眼睛表面施用至受试者眼睛目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如SEQ ID NO：5、SEQ ID NO：8-10、SEQ ID NO：26-27和SEQ ID NO：30-44任一所述。

61.根据权利要求60所述的方法，其中所述目标基因如SEQ IDNO：36-SEQ ID NO：44任一所述。

62.一种治疗需要治疗受试者老年性黄斑变性(AMD)的方法，所述方法包括局部向受试者眼睛表面施用至受试者眼睛目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如SEQ ID NO：1-3、SEQID NO：5-10、SEQ ID NO：12-13、SEQ ID NO：24-27、SEQ IDNO：30-35、SEQ ID NO：45-53任一所述。

63.根据权利要求62所述的方法，其中所述目标基因如SEQ IDNO：3、SEQ ID NO：12和SEQ ID NO：47任一所述。

64.一种治疗需要治疗受试者糖尿病性黄斑水肿(DME)的方法，所述方法包括局部向受试者眼睛表面施用至受试者眼睛目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如SEQ ID NO：1-3、SEQID NO：5-10、SEQ ID NO：12-13、SEQ ID NO：24-27、SEQ IDNO：30-35、SEQ ID NO：45-53任一所述。

65.根据权利要求64所述的方法，其中所述目标基因如SEQ IDNO：3、SEQ ID NO：12和SEQ ID NO：47任一所述。

66.一种治疗需要治疗受试者糖尿病视网膜病变(DR)的方法，所述方法包括局部向受试者眼睛表面施用至受试者眼睛目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如SEQIDNO：1-3、SEQID NO：5-10、SEQ ID NO：12-13、SEQ ID NO：24-27、SEQ ID NO：30-35、SEQ ID NO：45-53任一所述。

67.根据权利要求66所述的方法，其中所述目标基因如SEQ IDNO：48-53任一所述。

68.一种治疗需要治疗受试者色素性视网膜炎(RP)的方法，所述方法包括局部向受试者眼睛表面施用至受试者眼睛目标基因的治疗有效量的至少一种siRNA，其中所述目标基因如SEQ ID NO：3、SEQ IDNO：14、SEQ ID NO：26-35和SEQ ID NO：54-58任一所述。

69.根据权利要求68所述的方法，其中所述目标基因如SEQ IDNO：56-57任一所述。

70.根据权利要求57至69任一所述的方法，其中所述siRNA被配制用于向眼睛表面局部施用。

71.根据权利要求57或69任一所述的方法，其中所述siRNA被配制为霜、泡沫、膏、软膏、乳剂、液体溶液、滴眼剂、凝胶、喷雾、悬浮液、微乳液、微球、微囊剂、纳米球、纳米粒子、脂质囊泡、脂质体、聚合物囊泡、眼罩或隐形眼镜。

72.根据权利要求71所述的方法，其中所述siRNA被配制为滴眼剂。

73.根据权利要求57或72任一所述的方法，其中所述siRNA是以滴眼剂给药。

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