CN102448496A - 含碘和类固醇的药物组合物及其用于治疗鼻炎疾病的用途 - Google Patents
含碘和类固醇的药物组合物及其用于治疗鼻炎疾病的用途 Download PDFInfo
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- CN102448496A CN102448496A CN2011800013970A CN201180001397A CN102448496A CN 102448496 A CN102448496 A CN 102448496A CN 2011800013970 A CN2011800013970 A CN 2011800013970A CN 201180001397 A CN201180001397 A CN 201180001397A CN 102448496 A CN102448496 A CN 102448496A
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- CFNCFMKWDPDIPT-UHFFFAOYSA-N methyl 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoate Chemical compound COC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F CFNCFMKWDPDIPT-UHFFFAOYSA-N 0.000 description 1
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- QMDUPVPMPVZZGK-UHFFFAOYSA-N n,n-dimethyloctadecan-1-amine;hydrobromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[NH+](C)C QMDUPVPMPVZZGK-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 229940100652 nasal gel Drugs 0.000 description 1
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- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
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- SNGREZUHAYWORS-UHFFFAOYSA-N perfluorooctanoic acid Chemical compound OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F SNGREZUHAYWORS-UHFFFAOYSA-N 0.000 description 1
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- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
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- 230000002335 preservative effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
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- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
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- 229930193551 sterin Natural products 0.000 description 1
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- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 231100000617 superantigen Toxicity 0.000 description 1
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- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (39)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2011/041470 WO2012177251A1 (en) | 2011-06-22 | 2011-06-22 | Pharmaceutical compositions comprising iodine and steroid and uses thereof for sinus diseases |
Publications (2)
Publication Number | Publication Date |
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CN102448496A true CN102448496A (zh) | 2012-05-09 |
CN102448496B CN102448496B (zh) | 2015-04-15 |
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CN201180001397.0A Active CN102448496B (zh) | 2011-06-22 | 2011-06-22 | 含碘和类固醇的药物组合物及其用于治疗鼻炎疾病的用途 |
Country Status (3)
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US (2) | US11986491B2 (zh) |
CN (1) | CN102448496B (zh) |
WO (1) | WO2012177251A1 (zh) |
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CN110869023A (zh) * | 2017-09-02 | 2020-03-06 | 艾威药业公司 | 原位凝胶形成药物组合物及其在鼻窦疾病中的应用 |
WO2021151403A3 (zh) * | 2021-03-24 | 2022-02-17 | 厦门大开生物科技有限公司 | 一种含有聚维酮碘的消毒剂组合物及其用途 |
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JP2017522330A (ja) * | 2014-07-23 | 2017-08-10 | ファイアブリック・ファーマ・ピー・ティー・ワイ.エル・ティー・ディーFirebrick Pharma Pty Ltd | ポビドンヨードを使用した感冒の治療および予防 |
CA2990627A1 (en) * | 2015-06-22 | 2016-12-29 | Infection Containment Company, LLC | Topical antiseptic system |
EP3365022A4 (en) * | 2015-10-25 | 2019-07-24 | IVIEW Therapeutics, Inc. | PHARMACEUTICAL FORMULATIONS THAT FORM A GEL IN SITU |
BR112019001054A2 (pt) | 2016-07-21 | 2019-04-30 | Iogen, Llc | desinfetantes tópicos emolientes |
KR20220018570A (ko) | 2019-06-10 | 2022-02-15 | 화이어브릭 파마 리미티드 | 점액막에 포비돈 요오드를 국소 적용하는, 고병원성 바이러스에 의한 감염 예방 |
US20220288108A1 (en) * | 2019-08-30 | 2022-09-15 | 3M Innovative Properties Company | Transmission prevention of viruses with application of antiseptic composition |
WO2021055636A1 (en) * | 2019-09-17 | 2021-03-25 | Topical Sinus Therapeutics, Inc. | Therapeutic uses and methods of delivery of viscous compositions during pre and post surgical periods, for treatment of responsive diseases of the ear, nose, and throat |
WO2021202332A1 (en) * | 2020-03-28 | 2021-10-07 | Iview Therapeutics, Inc. | Aqueous formulations containing povidone iodine for effective treatment and prevention of virus infections |
NL2025641B1 (en) * | 2020-04-17 | 2023-06-22 | Veloce Biopharma Llc | Methods and compositions for improved treatment of sinus disease |
WO2021216915A1 (en) * | 2020-04-22 | 2021-10-28 | Topical Sinus Therapeutics, Inc. | Topical preparations of drug delivery for nasal and sinus irrigation |
CN111793532A (zh) * | 2020-07-29 | 2020-10-20 | 南通大学附属医院 | 一种剖宫产术中胎脂的清除方法 |
EP4340848A1 (en) * | 2021-05-18 | 2024-03-27 | Povinez LLC | Nasal antiseptic |
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- 2011-06-22 US US14/127,846 patent/US11986491B2/en active Active
- 2011-06-22 WO PCT/US2011/041470 patent/WO2012177251A1/en active Application Filing
- 2011-06-22 CN CN201180001397.0A patent/CN102448496B/zh active Active
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2017
- 2017-08-16 US US15/678,836 patent/US20170348348A1/en active Pending
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CN102078325A (zh) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | 含有聚维酮碘与环糊精包合糖皮质激素的鼻用组合物 |
CN102078326A (zh) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | 含有聚维酮碘与糠酸莫米松的局部使用组合物 |
CN102078611A (zh) * | 2009-11-26 | 2011-06-01 | 天津金耀集团有限公司 | 含有聚维酮碘与环糊精包合糖皮质激素的局部外用组合物 |
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US11986491B2 (en) | 2024-05-21 |
CN102448496B (zh) | 2015-04-15 |
US20170348348A1 (en) | 2017-12-07 |
US20140219949A1 (en) | 2014-08-07 |
WO2012177251A1 (en) | 2012-12-27 |
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