CN102448485A - 免疫原性组合物及其用途 - Google Patents
免疫原性组合物及其用途 Download PDFInfo
- Publication number
- CN102448485A CN102448485A CN2009801596118A CN200980159611A CN102448485A CN 102448485 A CN102448485 A CN 102448485A CN 2009801596118 A CN2009801596118 A CN 2009801596118A CN 200980159611 A CN200980159611 A CN 200980159611A CN 102448485 A CN102448485 A CN 102448485A
- Authority
- CN
- China
- Prior art keywords
- immunogenic composition
- antigen
- cys
- dendritic cell
- tlr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/77—Ovalbumin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6018—Lipids, e.g. in lipopeptides
Abstract
Description
Claims (21)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPCT/AU2009/000446 | 2009-04-09 | ||
PCT/AU2009/000446 WO2010115229A1 (en) | 2009-04-09 | 2009-04-09 | Immunogenic composition and uses thereof |
PCT/AU2009/000469 WO2010115230A1 (en) | 2009-04-09 | 2009-04-16 | Immunogenic composition and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102448485A true CN102448485A (zh) | 2012-05-09 |
CN102448485B CN102448485B (zh) | 2015-01-14 |
Family
ID=42935575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980159611.8A Active CN102448485B (zh) | 2009-04-09 | 2009-04-16 | 免疫原性组合物及其用途 |
Country Status (6)
Country | Link |
---|---|
US (2) | US20120064109A1 (zh) |
EP (2) | EP2416801B1 (zh) |
JP (1) | JP2012523379A (zh) |
CN (1) | CN102448485B (zh) |
CA (1) | CA2758204A1 (zh) |
WO (2) | WO2010115229A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2702154C (en) * | 2007-10-09 | 2017-05-16 | The University Of Melbourne | A method of transfection and compositions therefor |
WO2012037612A1 (en) | 2010-09-22 | 2012-03-29 | The University Of Melbourne | Novel immunostimulatory method |
US8883717B2 (en) | 2012-03-30 | 2014-11-11 | Artificial Cell Technologies, Inc. | Antigenic compositions and methods |
US9433671B2 (en) * | 2012-03-30 | 2016-09-06 | Artificial Cell Technologies, Inc. | Anti-malaria compositions and methods |
WO2016037240A1 (en) * | 2014-09-12 | 2016-03-17 | The University Of Melbourne | Immunological reagent |
KR20170094449A (ko) | 2014-12-23 | 2017-08-17 | 마가렛 앤 브림블 | 아미노산 및 펩타이드 접합체 및 이들의 용도 |
MX2018003103A (es) | 2015-09-16 | 2018-06-11 | Artificial Cell Tech Inc | Composiciones y procedimientos contra la malaria. |
CA3014515A1 (en) | 2016-02-26 | 2017-08-31 | Auckland Uniservices Limited | Amino acid and peptide conjugates and conjugation process |
JP2020512336A (ja) | 2017-03-31 | 2020-04-23 | イーナ セラピューティクス ピーティーワイ リミテッド | Tlrアゴニストによる呼吸器感染症の治療 |
US20200361864A1 (en) * | 2017-08-30 | 2020-11-19 | Auckland Uniservices Limited | Peptide Conjugates, Conjugation Process, and Uses Thereof |
WO2023028649A1 (en) * | 2021-08-31 | 2023-03-09 | Ena Respiratory Pty Ltd | Allergy treatment |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ518999A (en) | 1999-11-19 | 2002-12-20 | Csl Ltd | Vaccine compositions |
CN1688605B (zh) | 2002-08-12 | 2011-01-12 | 昆士兰医学研究所理事会 | 包含辅助t细胞和细胞毒性t淋巴细胞(ctl)表位的新免疫原性脂肽 |
US7569225B2 (en) | 2002-08-12 | 2009-08-04 | The Council Of The Queensland Institute Of Medical Research | Immunogenic lipopeptides comprising T-helper and B-cell epitopes |
GB0318247D0 (en) * | 2003-08-05 | 2003-09-10 | Royal Veterinary College | Antigen delivery system |
EP1550458A1 (en) | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
GB0411411D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxosmithkline Biolog Sa | Vaccines |
AU2005295317B2 (en) | 2004-10-18 | 2011-10-13 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
EP1666056A1 (en) * | 2004-12-06 | 2006-06-07 | Bestewil Holding B.V. | Cancer vaccine vesicles |
SG160424A1 (en) | 2004-12-21 | 2010-04-29 | Vaxinnate Corp | Compositions of influenza viral proteins and methods of use thereof |
DK1850832T3 (en) * | 2005-02-07 | 2015-04-13 | Lipotek Pty Ltd | adjuvanting |
EP1861426A4 (en) | 2005-02-08 | 2008-11-12 | Queensland Inst Med Res | IMMUNOGENOUS MOLECULES |
WO2006091591A1 (en) | 2005-02-22 | 2006-08-31 | The Regents Of The University Of California | Methods of treating gastrointestinal inflammation |
TW200800252A (en) * | 2005-12-08 | 2008-01-01 | Northwest Biotherapeutics Inc | Compositions and methods for inducing the activation of immature monocytic dendritic cells |
JP4929290B2 (ja) * | 2005-12-23 | 2012-05-09 | ヴァクソン バイオテック | 腫瘍抗原由来最適化潜在性ペプチドで構成される免疫原性ポリペプチド及びその使用 |
US20080170996A1 (en) | 2006-07-28 | 2008-07-17 | The Board Of Regents Of The University Of Texas System | Compositions and Methods for Stimulation of Lung Innate Immunity |
CA2702154C (en) | 2007-10-09 | 2017-05-16 | The University Of Melbourne | A method of transfection and compositions therefor |
US8728465B2 (en) | 2008-06-17 | 2014-05-20 | Cedars-Sinai Medical Center | Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors |
US20110171259A1 (en) | 2008-09-05 | 2011-07-14 | Martin Gagne | Novel Compositions and Adjuvants |
SG173617A1 (en) | 2009-02-11 | 2011-09-29 | Univ California | Toll-like receptor modulators and treatment of diseases |
PT2411521E (pt) | 2009-03-25 | 2015-04-21 | Univ Texas | Composições para estimulação de resistência imunitária inata de mamíferos contra patogénicos |
EP2338521A1 (en) | 2009-12-28 | 2011-06-29 | Helmholtz-Zentrum für Infektionsforschung GmbH | Lipopeptide- and lipoprotein-conjugates and its use |
-
2009
- 2009-04-09 WO PCT/AU2009/000446 patent/WO2010115229A1/en active Application Filing
- 2009-04-09 JP JP2012503830A patent/JP2012523379A/ja active Pending
- 2009-04-16 CA CA2758204A patent/CA2758204A1/en not_active Abandoned
- 2009-04-16 CN CN200980159611.8A patent/CN102448485B/zh active Active
- 2009-04-16 WO PCT/AU2009/000469 patent/WO2010115230A1/en active Application Filing
- 2009-04-16 EP EP09842850.1A patent/EP2416801B1/en not_active Not-in-force
- 2009-04-16 EP EP15170809.6A patent/EP2946789B1/en active Active
-
2011
- 2011-10-07 US US13/268,069 patent/US20120064109A1/en not_active Abandoned
-
2015
- 2015-01-22 US US14/602,778 patent/US9889195B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20120064109A1 (en) | 2012-03-15 |
WO2010115230A1 (en) | 2010-10-14 |
EP2416801A1 (en) | 2012-02-15 |
EP2946789B1 (en) | 2018-02-28 |
CN102448485B (zh) | 2015-01-14 |
CA2758204A1 (en) | 2010-10-14 |
US20150150966A1 (en) | 2015-06-04 |
EP2946789A1 (en) | 2015-11-25 |
EP2416801B1 (en) | 2015-07-22 |
US9889195B2 (en) | 2018-02-13 |
EP2416801A4 (en) | 2012-09-26 |
WO2010115229A1 (en) | 2010-10-14 |
JP2012523379A (ja) | 2012-10-04 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170823 Address after: Victoria, Australia Patentee after: Innawak Pte. Ltd. Address before: Victoria, Australia Patentee before: THE University OF MELBOURNE |
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CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: Vitoria, Australia Patentee after: Ena Therapeutics Pty Ltd. Address before: Vitoria, Australia Patentee before: Innawak Pte. Ltd. Address after: Vitoria, Australia Patentee after: Axelia oncology Pte. Ltd. Address before: Vitoria, Australia Patentee before: Ena Therapeutics Pty Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221221 Address after: New South Wales,Australia Patentee after: Aina Breathing Pte. Ltd. Address before: Vitoria, Australia Patentee before: Axelia oncology Pte. Ltd. |