CN102440977B - 一种丁二磺酸腺苷酸肠溶组合物及制备方法 - Google Patents
一种丁二磺酸腺苷酸肠溶组合物及制备方法 Download PDFInfo
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- CN102440977B CN102440977B CN201110290209.2A CN201110290209A CN102440977B CN 102440977 B CN102440977 B CN 102440977B CN 201110290209 A CN201110290209 A CN 201110290209A CN 102440977 B CN102440977 B CN 102440977B
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- acid
- disulfonic acid
- adenylic acid
- adenylic
- granule
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- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 title claims abstract description 29
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 title claims abstract description 29
- 229950006790 adenosine phosphate Drugs 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000203 mixture Substances 0.000 title abstract description 17
- FUDAIDRKVVTJFF-UHFFFAOYSA-N butane-1,1-disulfonic acid Chemical compound CCCC(S(O)(=O)=O)S(O)(=O)=O FUDAIDRKVVTJFF-UHFFFAOYSA-N 0.000 title abstract 6
- 239000002245 particle Substances 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000001291 vacuum drying Methods 0.000 claims abstract description 9
- 239000008187 granular material Substances 0.000 claims description 49
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 36
- 239000002253 acid Substances 0.000 claims description 27
- 235000019359 magnesium stearate Nutrition 0.000 claims description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 17
- 239000000741 silica gel Substances 0.000 claims description 17
- 229910002027 silica gel Inorganic materials 0.000 claims description 17
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 9
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 9
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 9
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 9
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 9
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000002662 enteric coated tablet Substances 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 12
- 229920000642 polymer Polymers 0.000 abstract 2
- 206010008635 Cholestasis Diseases 0.000 abstract 1
- 230000007870 cholestasis Effects 0.000 abstract 1
- 231100000359 cholestasis Toxicity 0.000 abstract 1
- 238000005253 cladding Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 description 17
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 12
- 229960001570 ademetionine Drugs 0.000 description 11
- 238000012856 packing Methods 0.000 description 9
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 229920002472 Starch Polymers 0.000 description 7
- 230000001476 alcoholic effect Effects 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- 235000019890 Amylum Nutrition 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000004925 Acrylic resin Substances 0.000 description 3
- 229920000178 Acrylic resin Polymers 0.000 description 3
- 239000001856 Ethyl cellulose Substances 0.000 description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 3
- 229920001249 ethyl cellulose Polymers 0.000 description 3
- 235000019325 ethyl cellulose Nutrition 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 229960003943 hypromellose Drugs 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- -1 adenosine phosphates Chemical class 0.000 description 2
- 208000019425 cirrhosis of liver Diseases 0.000 description 2
- 208000001024 intrahepatic cholestasis Diseases 0.000 description 2
- 230000007872 intrahepatic cholestasis Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001587 cholestatic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- HHCCNQLNWSZWDH-UHFFFAOYSA-N n-hydroxymethanimine oxide Chemical compound O[N+]([O-])=C HHCCNQLNWSZWDH-UHFFFAOYSA-N 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
Description
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Priority Applications (1)
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CN201110290209.2A CN102440977B (zh) | 2011-09-18 | 2011-09-18 | 一种丁二磺酸腺苷酸肠溶组合物及制备方法 |
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CN201110290209.2A CN102440977B (zh) | 2011-09-18 | 2011-09-18 | 一种丁二磺酸腺苷酸肠溶组合物及制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102440977A CN102440977A (zh) | 2012-05-09 |
CN102440977B true CN102440977B (zh) | 2014-05-28 |
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CN201110290209.2A Active CN102440977B (zh) | 2011-09-18 | 2011-09-18 | 一种丁二磺酸腺苷酸肠溶组合物及制备方法 |
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Families Citing this family (2)
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CN114272220B (zh) * | 2021-12-22 | 2023-06-30 | 南京美瑞制药有限公司 | 一种丁二磺酸腺苷蛋氨酸肠溶片组合物及其制备方法 |
CN114306266A (zh) * | 2022-01-06 | 2022-04-12 | 济南同路医药科技发展有限公司 | 丁二磺酸腺苷蛋氨酸肠溶组合物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1943787A (zh) * | 2006-10-24 | 2007-04-11 | 北京中医药大学 | 一种药物防潮组合物及其制备方法 |
CN101584684A (zh) * | 2009-06-04 | 2009-11-25 | 无锡鼎福药业有限公司 | 包括s-腺苷蛋氨酸稳定性盐的肠溶制剂及其制备方法 |
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2011
- 2011-09-18 CN CN201110290209.2A patent/CN102440977B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1943787A (zh) * | 2006-10-24 | 2007-04-11 | 北京中医药大学 | 一种药物防潮组合物及其制备方法 |
CN101584684A (zh) * | 2009-06-04 | 2009-11-25 | 无锡鼎福药业有限公司 | 包括s-腺苷蛋氨酸稳定性盐的肠溶制剂及其制备方法 |
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Effective date of registration: 20180424 Address after: 100070 Beijing City, Fengtai District zaojiacheng Street South Lane No. 5 4A No. 2 layer Co-patentee after: JILIN DESHANG PHARMACEUTICAL CO.,LTD. Patentee after: BEIJING MANGE PHARMACEUTICAL S. & T. CO.,LTD. Address before: 100070 Beijing City, Fengtai District zaojiacheng Street South Lane No. 5 4A No. 2 layer Patentee before: BEIJING MANGE PHARMACEUTICAL S. & T. CO.,LTD. |
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Denomination of invention: The invention relates to adenylate succinate enteric coated composition and a preparation method thereof Effective date of registration: 20210507 Granted publication date: 20140528 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: JILIN DESHANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2021220000046 |
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Date of cancellation: 20220810 Granted publication date: 20140528 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: JILIN DESHANG PHARMACEUTICAL CO.,LTD. Registration number: Y2021220000046 |
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Denomination of invention: A kind of butanedisulfonic acid adenylate enteric-coated composition and preparation method thereof Effective date of registration: 20220811 Granted publication date: 20140528 Pledgee: Tonghua Branch of China Everbright Bank Co.,Ltd. Pledgor: JILIN DESHANG PHARMACEUTICAL CO.,LTD. Registration number: Y2022220000054 |
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