CN102423369B - Chinese medicinal composition for preventing or treating ovarian cancer - Google Patents
Chinese medicinal composition for preventing or treating ovarian cancer Download PDFInfo
- Publication number
- CN102423369B CN102423369B CN201110449211A CN201110449211A CN102423369B CN 102423369 B CN102423369 B CN 102423369B CN 201110449211 A CN201110449211 A CN 201110449211A CN 201110449211 A CN201110449211 A CN 201110449211A CN 102423369 B CN102423369 B CN 102423369B
- Authority
- CN
- China
- Prior art keywords
- parts
- ovarian cancer
- chinese
- chinese medicine
- medicinal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract description 33
- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims abstract description 20
- 239000003814 drug Substances 0.000 claims abstract description 42
- 239000007788 liquid Substances 0.000 claims description 30
- 241000237903 Hirudo Species 0.000 claims description 9
- 230000002265 prevention Effects 0.000 claims description 6
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 241000555682 Forsythia x intermedia Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 21
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 240000005528 Arctium lappa Species 0.000 abstract description 2
- 235000003130 Arctium lappa Nutrition 0.000 abstract description 2
- 240000001745 Rheum palmatum Species 0.000 abstract description 2
- 235000008078 Arctium minus Nutrition 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000510667 Conioselinum Species 0.000 abstract 1
- 244000301850 Cupressus sempervirens Species 0.000 abstract 1
- 241000545744 Hirudinea Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 239000012567 medical material Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- 239000008280 blood Substances 0.000 description 13
- 206010028980 Neoplasm Diseases 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 238000004321 preservation Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 230000002401 inhibitory effect Effects 0.000 description 7
- 230000008961 swelling Effects 0.000 description 7
- 241000555712 Forsythia Species 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 206010037660 Pyrexia Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical group N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 4
- 229960004316 cisplatin Drugs 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010023126 Jaundice Diseases 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 208000031971 Yin Deficiency Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000001047 pyretic effect Effects 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010025421 Macule Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 2
- 241000207834 Oleaceae Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 244000089795 Clausena lansium Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000009849 Female Genital Neoplasms Diseases 0.000 description 1
- 241000576429 Forsythia suspensa Species 0.000 description 1
- 241000237678 Hirudinidae Species 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000218195 Lauraceae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 241000205407 Polygonum Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000405911 Rehmannia glutinosa Species 0.000 description 1
- 206010062104 Renal mass Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010043458 Thirst Diseases 0.000 description 1
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 206010047601 Vitamin B1 deficiency Diseases 0.000 description 1
- 241000258623 Whitmania pigra Species 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000002894 beriberi Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 208000019065 cervical carcinoma Diseases 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 210000004999 sex organ Anatomy 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal composition for preventing or treating ovarian cancer, and relates to the technical field of Chinese medicaments. The Chinese medicinal composition is prepared from the following active components in parts by weight: 10 to 15 parts of golden cypress, 10 to 15 parts of burdock, 15 to 20 parts of fructus forsythiae, 15 to 18 parts of dandelion, 12 to 16 parts of hemlock parsley, 12 to 16 parts of cassia twig, 10 to 15 parts of Chinese rhubarb, 14 to 18 parts of rehmannia, and 6 to 10 parts of leech. The Chinese medicinal composition disclosed by the invention has remarkable curative effect, low cost and hardly toxic or side effect, and can be combined with other treatment modes to achieve the aim of resisting ovarian cancer.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to the Chinese medicine composition of a kind of prevention or treatment ovarian cancer.
Background technology
Ovarian cancer is one of common tumor of female sex organ, and sickness rate is only second to cervical cancer and carcinoma of uterine body and is listed as and occupies the 3rd.But because of ovarian cancer causes the dead, but account for the first place of all kinds of gynecological tumors, women's life is caused serious threat.The cause of disease of ovarian cancer it be unclear that, and its morbidity maybe be relevant with age, fertility, blood group, Nervous and Mental Factors and environment etc.
The traditional Chinese medical science thinks that ovarian cancer belongs to " lump in the abdomen " of the traditional Chinese medical science, " gathering " category.The morbidity of ovarian cancer is because positive QI-insufficiency wins in the pathogen, and causes.Serve as the main double gas of setting upright to attack heresy at the initial stage of a disease generally; The positive deficiency of vital energy then mainly shows as deficiency of both QI and YIN.Later stage serves as that main holding concurrently removed pathogen to set upright then.Pathogen mainly contains qi depression to blood stasis, and noxious dampness is stopped up two types of Shengs.The Chinese traditional treatment ovarian cancer has important effect in the therapeutic process of ovarian cancer patients, got better curative effect clinically.The traditional Chinese medical herbal treatment ovarian cancer both can anticancer, and it is basic to consolidate, and improves patient's self-resistance, and side effect is very little, is fit to life-time service, and effect is effectively unique.No matter be at perioperatively, or the auxiliary treatment of chemotherapeutic treatment, the Chinese medicine curative effect has all obtained clear and definite checking, plays the effect of Synergistic.
A large amount of clinical cases show that ovarian cancer can make patient's the state of an illness be greatly improved through the Chinese medicine combined treatment, and immune treatment power improves, and alleviates patient's misery, improve life quality, prolong life, are a kind of therapy measure.The traditional Chinese medical herbal treatment of ovarian cancer can change the side reaction after the chemotherapy, plays the effect of killing cancerous cell, has also reduced postoperative damage.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treatment ovarian cancer of evident in efficacy, with low cost, almost non-toxic side effect.
The objective of the invention is to realize like this:
The Chinese medicine composition of a kind of prevention or treatment ovarian cancer is prepared from following parts by weight of Chinese traditional medicine material: Cortex Phellodendri 10-15 part, Fructus Arctii 10-15 part, Fructus Forsythiae 15-20 part, Herba Taraxaci 15-18 part, Rhizoma Chuanxiong 12-16 part, Ramulus Cinnamomi 12-16 part, Radix Et Rhizoma Rhei 10-15 part, Radix Rehmanniae 14-18 part, Hirudo 6-10 part.
In preferred embodiment of the present invention, the Chinese medicine composition of said prevention or treatment ovarian cancer is prepared from following parts by weight of Chinese traditional medicine material: 13 parts of Cortex Phellodendris, 12 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 16 parts in the Radix Rehmanniae, 8 parts of Hirudos.
The Chinese medicine composition of above-mentioned any prevention or treatment ovarian cancer can be oral liquid.
According to the record of Chinese medicine historical data, above-mentioned nine flavor Chinese medicines have following pharmacologically active:
Cortex Phellodendri: heat clearing and damp drying, eliminating fire and detoxication removes the hectic fever due to YIN-deficiency clearind deficient heat.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Be selected from the dry bark of rutaceae wampee or Cortex Phellodendri.
Fructus Arctii: have the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly that cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule do not pass through, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Fructus Forsythiae: control calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.Be selected from the dry fruit of Oleaceae (Oleaceae) Forsythia (Forsythia) plant Fructus Forsythiae (Forsythia suspensa (Thunb.) Vahl).
Herba Taraxaci: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Be selected from the herb of dry Herba Taraxaci.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Select samphire Rhizoma Chuanxiong rhizome for use.
Ramulus Cinnamomi: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Select the cinnamomic dry twig of Lauraceae aiphyllium plant for use.
Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Be selected from the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L..
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Be selected from the fresh or exsiccant tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch..
Hirudo: removing blood stasis, removing blood stasis stimulates the menstrual flow.Be used for diseases such as menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas.Be selected from the dry all of Hirudinidae animal Hirudo Whitmania pigra Whitman.
The method for preparing that above-mentioned each Chinese crude drug is prepared into compound preparation of the present invention is:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water that the first time, totalling medical material 8-12 doubly measured decocts 2h, gets decocting liquid; Filter, the water that the second time, totalling medical material 8-10 doubly measured decocts 2h; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 0-5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2-2.5g crude drug amount to every milliliter, stirs, and puts 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
The present invention has following useful effect and obvious improvement: Chinese medicine composition of the present invention can combine to use the purpose that reaches effective treatment ovarian cancer with other treatment mode (like operation, chemotherapy etc.).Animal test results shows (referring to table 1), compare with model control group, each treatment group to the inhibitory action of the tumor growth in the mouse ovarian cancer model all have significant difference (
P＜0.05), this explains that Chinese medicine composition of the present invention has extremely significant curative effect aspect the treatment ovarian cancer.In addition; Test group of the present invention is compared aspect the tumour inhibiting rate with chemotherapy cisplatin group does not have significant difference; This explains that the curative effect of Chinese medicine composition of the present invention is suitable with chemotherapeutics, and when obtaining remarkable drug effect, has the low advantage of toxic and side effects, has obtained unforeseeable technique effect.
The specific embodiment
Below be specific embodiment of the present invention, technical scheme of the present invention is done further to describe, but protection scope of the present invention be not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of the Chinese medicine oral liquid of embodiment 1 treatment ovarian cancer
Crude drug prescription: 13 parts of Cortex Phellodendris, 12 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 16 parts in the Radix Rehmanniae, 8 parts of Hirudos.
The method for preparing of oral liquid:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 10 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 10 times of amounts of totalling medical material decocts 2h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 5 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2.5g crude drug amount to every milliliter, stirs, and puts 2 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
The preparation of the Chinese medicine oral liquid of embodiment 2 treatment ovarian cancers
Crude drug prescription: 10 parts of Cortex Phellodendris, 10 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 12 parts of Rhizoma Chuanxiongs, 12 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 18 parts in the Radix Rehmanniae, 10 parts of Hirudos.
The method for preparing of oral liquid:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 8 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 8 times of amounts of totalling medical material decocts 2h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 4 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2g crude drug amount to every milliliter, stirs, and puts 5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
The preparation of the Chinese medicine oral liquid of embodiment 3 treatment ovarian cancers
Crude drug prescription: 15 parts of Cortex Phellodendris, 15 parts of Fructus Arctiis, 20 parts of Fructus Forsythiaes, 18 parts of Herba Taraxacis, 16 parts of Rhizoma Chuanxiongs, 16 parts of Ramulus Cinnamomi, 15 parts of Radix Et Rhizoma Rhei, 18 parts in the Radix Rehmanniae, 8 parts of Hirudos.
Oral liquor:
(1) gets the above-mentioned Chinese crude drug of recipe quantity, clean roguing, dry, be ground into granule;
(2) more above-mentioned graininess medical material is added water and cover powder 2cm, soak 1-1.2h, pull medical material out and put decocte with water secondary in the multi-functional extraction filling; The water of 12 times of amounts of totalling medical material decocts 2h for the first time, gets decocting liquid; Filter, the water of 10 times of amounts of totalling medical material decocts 2h for the second time; Get twice decocting liquid and merge, filter, relative density is 1.25 concentrated solution when being concentrated into 90 ℃;
(3) concentrated solution is put 2 ℃ of deepfreeze 24h, cold preservation liquid is added 0.3% filter aid kieselguhr, filter, the filtrating reconcentration contains 2.5g crude drug amount to every milliliter, stirs, and puts 4 ℃ of deepfreeze 24h, cold preservation liquid is filtered, oral liquid.
Embodiment 4 Chinese medicine compositions of the present invention are to the inhibitory action of transplantability ovarian cancer
Get 4-6 nude mice in age in week, subcutaneous injection 2 * 10 in mice omoplate district
5The ovarian cancer cell strain SKOV3 cell 0.5ml of/ml exponential phase.After planting for 2 weeks, the mice of the tumor body of selection formation diameter 1-2cm is for use.The nude mice of ovarian cancer subcutaneous transplantation tumor animal model is divided into following 3 groups at random: model control group, positive controls, test group, 8 every group.With the positive contrast of cisplatin, intraperitoneal administration, successive administration l2d.Model control group is irritated stomach equal-volume 0.9% normal saline, and test group is irritated the Chinese medicine oral liquid of the stomach 32ml/kg/d embodiment of the invention 1 preparation, all successive administration 45d.Administering mode is seen table 1.After each organizes drug withdrawal 2d, take off neck and put to death mice, separate tumor, survey volume, weigh, calculate tumor suppression percentage rate=(it is heavy that the average tumor of average tumor weight/model control group is organized in the 1-treatment) * 100%.
Table 1 is respectively organized the mice administering mode
| Group | Administering mode |
| Model control group | Irritate stomach equal-volume 0.9% normal saline |
| Positive controls | Lumbar injection 15mg/ (kgd) cisplatin |
| Test group | Irritate the Chinese medicine oral liquid of the stomach 32ml/kg/d embodiment of the invention 1 preparation |
Result of the test shows (referring to table 2): compare with model control group, each treatment group to the inhibitory action of the tumor growth in the mouse ovarian cancer model all have significant difference (
P＜0.05), this explains that Chinese medicine composition of the present invention has extremely significant curative effect aspect the treatment ovarian cancer.In addition; Test group of the present invention is compared aspect the tumour inhibiting rate with chemotherapy cisplatin group does not have significant difference; This explains that the curative effect of Chinese medicine composition of the present invention is suitable with chemotherapeutics, and when obtaining remarkable drug effect, has the low advantage of toxic and side effects, has obtained unforeseeable technique effect.
Table 2 Chinese medicine composition of the present invention is to the inhibitory action of transplantability ovarian cancer
| Group | Gross tumor volume (cm 3） | Tumor heavy (g) | Average tumour inhibiting rate (%) |
| Model control group | 3.82 | 2.34±0.29 | ? |
| Positive controls | 1.85 | 1.12±0.35 ** | 52.6 |
| Test group | 1.20 | 1.62±0.43 * | 32.3 |
Compare * with model control group
P＜0.05, * *
P＜0.01.
Claims (2)
1. a Chinese medicine composition that prevents or treat ovarian cancer is characterized in that: be prepared from following parts by weight of Chinese traditional medicine material: Cortex Phellodendri 10-15 part, Fructus Arctii 10-15 part, Fructus Forsythiae 15-20 part, Herba Taraxaci 15-18 part, Rhizoma Chuanxiong 12-16 part, Ramulus Cinnamomi 12-16 part, Radix Et Rhizoma Rhei 10-15 part, Radix Rehmanniae 14-18 part, Hirudo 6-10 part; Said Chinese medicine composition is an oral liquid.
2. the Chinese medicine composition of prevention as claimed in claim 1 or treatment ovarian cancer is characterized in that: be prepared from following parts by weight of Chinese traditional medicine material: 13 parts of Cortex Phellodendris, 12 parts of Fructus Arctiis, 16 parts of Fructus Forsythiaes, 16 parts of Herba Taraxacis, 15 parts of Rhizoma Chuanxiongs, 15 parts of Ramulus Cinnamomi, 12 parts of Radix Et Rhizoma Rhei, 16 parts in the Radix Rehmanniae, 8 parts of Hirudos.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110449211A CN102423369B (en) | 2011-12-29 | 2011-12-29 | Chinese medicinal composition for preventing or treating ovarian cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110449211A CN102423369B (en) | 2011-12-29 | 2011-12-29 | Chinese medicinal composition for preventing or treating ovarian cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102423369A CN102423369A (en) | 2012-04-25 |
| CN102423369B true CN102423369B (en) | 2012-09-05 |
Family
ID=45957456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110449211A Active CN102423369B (en) | 2011-12-29 | 2011-12-29 | Chinese medicinal composition for preventing or treating ovarian cancer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102423369B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833016A (en) * | 2016-05-26 | 2016-08-10 | 宋羽 | Traditional Chinese medicine composition for treating ovarian cancer |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158261A (en) * | 1996-10-18 | 1997-09-03 | 宁振峰 | Chinese Patent medicine |
| CN1421219A (en) * | 2001-11-27 | 2003-06-04 | 杨桂芬 | Chinese medicine for treating women's ovary cancer and uterine myoma |
-
2011
- 2011-12-29 CN CN201110449211A patent/CN102423369B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1158261A (en) * | 1996-10-18 | 1997-09-03 | 宁振峰 | Chinese Patent medicine |
| CN1421219A (en) * | 2001-11-27 | 2003-06-04 | 杨桂芬 | Chinese medicine for treating women's ovary cancer and uterine myoma |
Non-Patent Citations (2)
| Title |
|---|
| 王会仓等.中药复方土元汤治疗卵巢癌临床分析.《辽宁中医药大学学报》.2008,第10卷(第8期),110-111. * |
| 陈敏等.中药治疗卵巢癌机制研究进展.《辽宁中医药大学学报》.2010,第12卷(第3期),90-92. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102423369A (en) | 2012-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102423478B (en) | Pharmaceutical composition for treating chronic endometritis | |
| CN104147508A (en) | Traditional Chinese medicine composition for treating irregular menstruation | |
| CN104984316A (en) | Medicine for treating female cold in uterus | |
| CN103054990B (en) | Traditional Chinese medicine for treating functional abdominal pain in children and preparation method thereof | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN105497439A (en) | Medicine composition for treating gynecological postoperative low fever | |
| CN104922426A (en) | Pharmaceutical composition for treating post gynecologic operation low fever | |
| CN102423369B (en) | Chinese medicinal composition for preventing or treating ovarian cancer | |
| CN104189234A (en) | Traditional Chinese medicine preparation for treating metrorrhagia and metrostaxis | |
| CN106902307A (en) | A kind of Chinese medicine composition and usage for treating malignant tumor of lung | |
| CN106177542A (en) | The Chinese prescription of a kind of summer heat clearing toxin resolving and goods thereof | |
| CN102861292B (en) | Medicament for treating esophageal cancer and preparation method thereof | |
| CN101983716A (en) | Medicine for treating gastric ulcer and duodenal ulcer and preparation method thereof | |
| CN105456815A (en) | Traditional Chinese medicine for inhibiting tumors and preparation method of traditional Chinese medicine | |
| CN104083580A (en) | Traditional Chinese medicine for treating senile dementia | |
| CN104288665A (en) | Particle for treating breast cancer | |
| CN102552541B (en) | Medicinal composition for preventing or treating breast cancer | |
| CN102886017A (en) | Traditional Chinese medicine for treating ovarian cyst | |
| CN106237206A (en) | A kind of Chinese medicine preparation treating tumor and preparation method thereof | |
| CN106421074A (en) | Traditional Chinese medicine composition with anti-cancer and anti-tumor functions and preparation method thereof | |
| CN102416059B (en) | Medicinal composition for treating colon cancer | |
| CN105012789A (en) | Composition for treating cervical cancer and preparation method thereof | |
| CN105055653A (en) | Medicine decoction for treating pulpitis and preparation method thereof | |
| CN104800533A (en) | Liupu tea containing composition with fire clearing function | |
| CN104491823A (en) | Traditional Chinese medicine electuary for treating dysmenorrheal and preparation method of traditional Chinese medicine electuary |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: RUDONG TECHNOLOGY CENTER Free format text: FORMER OWNER: XU CONGYU Effective date: 20131212 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276017 LINYI, SHANDONG PROVINCE TO: 226400 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20131212 Address after: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee after: Rudong science and Technology Center Address before: 276017 A302 building, Linyi hi tech Industrial Development Zone, Shandong, China Patentee before: Xu Congyu |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20200410 Address after: No. 10, Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Rudong industrial and commercial information consulting service center Address before: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee before: Rudong science and Technology Center |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211228 Address after: Fengli town Xinjian West Road, Rudong County, Nantong City, Jiangsu Province 226400 Patentee after: Rudong Wenyuan investment and Development Co., Ltd Address before: 226400 No.10 Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee before: Rudong industrial and commercial information consulting service center |
|
| TR01 | Transfer of patent right |