CN102414207B - 氟化氨基三唑衍生物 - Google Patents

氟化氨基三唑衍生物 Download PDF

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Publication number
CN102414207B
CN102414207B CN201080018293.6A CN201080018293A CN102414207B CN 102414207 B CN102414207 B CN 102414207B CN 201080018293 A CN201080018293 A CN 201080018293A CN 102414207 B CN102414207 B CN 102414207B
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methyl
ethyl
oxazole
difluoro
carboxylic acid
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Expired - Fee Related
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CN102414207A (zh
Inventor
丹尼尔·布尔
奥利维尔·考米波夫
塞尔文·库恩
科琳娜·格里索斯托米
泽维尔·莱罗尔
西尔维娅·里卡德-比尔德斯滕
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Aidu West Pharmaceutical Co Ltd
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Actelion Pharmaceuticals Ltd
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
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  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
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  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
CN201080018293.6A 2009-06-09 2010-06-07 氟化氨基三唑衍生物 Expired - Fee Related CN102414207B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2009052445 2009-06-09
IBPCT/IB2009/052445 2009-06-09
PCT/IB2010/052509 WO2010143116A1 (en) 2009-06-09 2010-06-07 Fluorinated aminotriazole derivatives

Publications (2)

Publication Number Publication Date
CN102414207A CN102414207A (zh) 2012-04-11
CN102414207B true CN102414207B (zh) 2015-09-30

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US (1) US8580831B2 (https=)
EP (1) EP2440555B1 (https=)
JP (2) JP5095035B2 (https=)
KR (1) KR101444559B1 (https=)
CN (1) CN102414207B (https=)
AR (1) AR077032A1 (https=)
AU (1) AU2010258334B2 (https=)
BR (1) BRPI1010738A8 (https=)
CA (1) CA2760588C (https=)
CL (1) CL2011003097A1 (https=)
ES (1) ES2587139T3 (https=)
IL (1) IL216792A (https=)
MA (1) MA33420B1 (https=)
MX (1) MX342440B (https=)
MY (1) MY161243A (https=)
NZ (1) NZ597453A (https=)
PL (1) PL2440555T3 (https=)
RU (1) RU2544862C2 (https=)
SG (1) SG175363A1 (https=)
TW (1) TWI404717B (https=)
WO (1) WO2010143116A1 (https=)
ZA (1) ZA201200127B (https=)

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AU2010250789B2 (en) 2009-05-18 2015-05-14 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists
CA2760887A1 (en) 2009-06-12 2010-12-16 Actelion Pharmaceuticals Ltd Oxazole and thiazole derivatives as alx receptor agonists
KR101905927B1 (ko) 2010-11-17 2018-10-08 이도르시아 파마슈티컬스 리미티드 가교된 스피로［２．４］헵탄 에스테르 유도체
CN103261194B (zh) 2010-12-07 2016-02-24 埃科特莱茵药品有限公司 作为alx受体激动剂的噁唑基-甲醚衍生物
KR101847672B1 (ko) * 2010-12-07 2018-04-10 이도르시아 파마슈티컬스 리미티드 Alx 수용체 작용제로서의 히드록실화 아미노트리아졸 유도체
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
CA2871334A1 (en) 2012-05-16 2013-11-21 Actelion Pharmaceuticals Ltd 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
ES2617863T3 (es) 2012-06-04 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de bencimidazol-prolina
EA201500399A1 (ru) 2012-10-10 2015-09-30 Актелион Фармасьютиклз Лтд. Антагонисты рецептора орексина, которые представляют собой производные [орто-би-(гетеро)арил]-[2-(мета-би-(гетеро)арил)пирролидин-1-ил]метанона
CA2902135A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
US10370451B2 (en) 2013-04-22 2019-08-06 The University Of Tokyo Preventive or therapeutic agent for inflammatory disease
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
WO2015007830A1 (en) 2013-07-18 2015-01-22 Actelion Pharmaceuticals Ltd Piperazine substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
SI3077391T1 (sl) 2013-12-04 2018-11-30 Idorsia Pharmaceuticals Ltd Uporaba benzimidazol-prolinskih derivatov
JP7763513B2 (ja) 2021-06-01 2025-11-04 アズキュリス カンパニー，リミテッド 新規オキサゾール誘導体、及びそれを含むアレルギー性疾患の予防又は治療用薬学的組成物

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NZ597453A (en) 2013-03-28
CA2760588C (en) 2017-08-08
JP5095035B2 (ja) 2012-12-12
CN102414207A (zh) 2012-04-11
MX342440B (es) 2016-09-29
TW201102383A (en) 2011-01-16
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BRPI1010738A8 (pt) 2017-12-26
RU2544862C2 (ru) 2015-03-20
CA2760588A1 (en) 2010-12-16
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SG175363A1 (en) 2011-12-29
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US20120101138A1 (en) 2012-04-26
CL2011003097A1 (es) 2012-07-06
AU2010258334B2 (en) 2015-02-26
BRPI1010738A2 (pt) 2016-03-15
TWI404717B (zh) 2013-08-11
EP2440555A1 (en) 2012-04-18
JP2012255002A (ja) 2012-12-27
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IL216792A (en) 2014-05-28
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EP2440555B1 (en) 2016-05-18
PL2440555T3 (pl) 2016-11-30
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