CN102389566A - Huidouba peptide polysaccharide-containing composition used for treating type II diabetes - Google Patents
Huidouba peptide polysaccharide-containing composition used for treating type II diabetes Download PDFInfo
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- CN102389566A CN102389566A CN2011103743958A CN201110374395A CN102389566A CN 102389566 A CN102389566 A CN 102389566A CN 2011103743958 A CN2011103743958 A CN 2011103743958A CN 201110374395 A CN201110374395 A CN 201110374395A CN 102389566 A CN102389566 A CN 102389566A
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- ramulus euonymi
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Abstract
The invention relates to a Huidouba peptide polysaccharide-containing composition, especially to a Huidouba peptide polysaccharide-containing composition used for treating type II diabetes, and mainly solves the problems of unsatisfactory demand of diabetic patients for blood sugar lowering effect, high cost and low effective rate in existing Huidouba peptide polysaccharide. The composition is mainly composed of Huidouba peptide polysaccharide, a euonymus alatus extract, a ginseng extract, an epimeddium extract, a combined spicebush extract, a costus root extract, a raw hawthorn extract, a balsampear seed extract, chitosan oligosaccharide and a sophora flavescens extract. The composition provided in the invention can address both the symptoms and root causes, and has the advantages of stable effect after recovery, low cost and substantial effect, etc.
Description
Technical field
What the present invention relates to is a kind of compositions that contains the HUIDOUBA peptide polysaccharide, specifically is meant a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type.
Background technology
Modern medicine is divided into two big types with diabetes: insulin dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes mellitus.Is that type serves as maximum in China with non-insulin-dependent diabetes mellitus.The classification of the diabetes traditional Chinese medical science can be divided into 5 types: 1, type of deficiency of both QI and YIN; 2, type of hyperactivity of fire caused by deficiency of YIN; 3, deficiency of both YIN and YANG type; 4, Qi deficiency blood stasis type; 5, scorchingly go into blood group.Wherein with type of deficiency of both QI and YIN for seeing at most.The syndrome of deficiency of both qi and yin diabetics shows as polydipsia, polyphagia, polyuria, and is weak, become thin, vulnerable, is prone to suffer from diseases caused by exogenous pathogenic factor, symptoms such as light red tongue is dark, deep-thready pulse.The syndrome of deficiency of both qi and yin diabetes promptly belong to type.
HUIDOUBA has invigorating the spleen and benefiting QI, and nourishing kidney yin is eliminated the diabetes-alleviating symptom, improves the beta Cell of islet deficiency, promotes the balance of nature of blood glucose in the body, Yin Yang balancing, and the QI and blood regulating is corrected the metabolism wadding disorderly, prevents functions such as diabetic complication.The maximum effect of HUIDOUBA is exactly to cure mainly diabetes, is applicable to all type patients, and being described as is the good folk prescription of treatment diabetes among the people.Effective blood sugar lowering material in the HUIDOUBA is exactly a peptide polysaccharide.If but just took peptide polysaccharide, then diabetic symptom would be improved effect and not obvious, and need take for a long time just and can play effect.
The compositions of existing treatment type is a lot, and not only cost is higher but have compositions now, and effective percentage is low.
Summary of the invention
The object of the invention provides had a kind ofly not only taken stopgap measures but also had effected a permanent cure and more back effect stability, cost is low, total effective rate is high a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type.
Realize that technical scheme of the present invention is following: a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type mainly is made up of following component: HUIDOUBA peptide polysaccharide, Ramulus euonymi extract; Radix Ginseng extract, Herba Epimedii extract, radix linderae extract; Radix Aucklandiae extract, Fructus Crataegi extract, Semen Momordicae Charantiae extract; Oligochitosan, Radix Sophorae Flavescentis extract.
Further, said compositions is made up of the component of following weight ratio: 4～8 parts of HUIDOUBA peptide polysaccharides, 1～4 part of Ramulus euonymi extract; 1～4 part of Radix Ginseng extract, 1～4 part of Herba Epimedii extract, 1～3 part of radix linderae extract, 1～3 part of Radix Aucklandiae extract; 1～4 part of Fructus Crataegi extract; 1～4 part of Semen Momordicae Charantiae extract, 1～4 part of oligochitosan, 1～3 part of Radix Sophorae Flavescentis extract.
Further, said compositions is made up of the component of following weight ratio: 6 parts of HUIDOUBA peptide polysaccharides, 2 parts of Ramulus euonymi extracts; 2 parts of Radix Ginseng extracts, 2 parts of Herba Epimedii extracts, 1 part of radix linderae extract; 1 part of Radix Aucklandiae extract, 2 parts of Fructus Crataegi extracts, 2 parts of Semen Momordicae Charantiae extracts; 2 parts of oligochitosans, 1 part of Radix Sophorae Flavescentis extract.
In order to obtain effective composition, the extraction step of said Ramulus euonymi extract is following:
(1) Ramulus Euonymi behind the acquisition removal impurity;
(2) Ramulus Euonymi is crushed to fineness to 20 orders;
(3) ratio in 1Kg Ramulus Euonymi and 10L water is put in it in extraction pot, refluxes 20～30 minutes, obtains extracting solution;
(4) with extracting solution suction concentration tank;
(5) under temperature is 90 ℃, vacuum for the condition between-0.05MPa and the-0.08MPa, concentrated this extracting solution;
(6) the spray-dried Ramulus euonymi extract that makes of extracting solution after said the concentrating.
In order better to realize the present invention, the extraction step of said Radix Ginseng extract, Herba Epimedii extract, radix linderae extract, Radix Aucklandiae extract, Fructus Crataegi extract, Semen Momordicae Charantiae extract, Radix Sophorae Flavescentis extract is identical with the extraction step of Ramulus euonymi extract.
The present invention has the following advantages and beneficial effect:
1, the present invention can regulate the nutrition supply and the metabolism reaction of pancreatic cell; Activate and keep the physiologically active of pancreatic cell; Mediation, regulate the sensitivity of multiple pancreatin system in the cell; Increase pancreatic cell to sugar, the absorption of amino acid nutrient composition strengthens the quantity and the functional activity that excite pancreatic cell;
2, the present invention can mediate the information transmission and the chain reaction of the multiple biological regulatory function of pancreatic cell;
3, the present invention has gene factor and the pancreatic cell tissue of repairing impaired mutation; Strengthen pancreas immunity; Directly act on pancreatic cell or repair beta Cell of islet impaired, variation; Increase islets of langerhans receptor, tyrosine activity and the bonded affinity of insulin, strengthen the function of the immunity of pancreatic cell, thereby can make the secretion of human insulin synthetic normal;
4, the effect stability behind the present invention more is difficult for recurrence, has no toxic and side effects;
5, average price of the present invention is cheap relatively, is suitable for promoting.
The specific embodiment
The present invention is the effectively basic prescription of treatment Qi and Yin deficiency diabetes mellitus.Through blood sugar control, recovery function, the body constitution of improving, human body immunity improving power, recovery beta Cell of islet function, the balance of nature of blood glucose in the promotion body, Yin Yang balancing, the QI and blood regulating, the correction metabolism is wadded a quilt with cotton random, prevents functions such as diabetic complication.Its maximum effect is exactly to cure mainly diabetes, is applicable to all type patients.
Below in conjunction with embodiment the present invention is done to specify further, but embodiment of the present invention is not limited thereto.
Embodiment
At first, obtain the HUIDOUBA peptide polysaccharide, the preparation process of said HUIDOUBA peptide polysaccharide is following:
(1) HUIDOUBA behind the acquisition removal impurity; Methods such as employing is chosen, chooses, winnows with a dustpan, sieves, scraped, brush are removed grey bits, impurity and non-HUIDOUBA, stay the HUIDOUBA mycelium.
(2) HUIDOUBA is crushed to fineness to 20 orders.
(3) get 1 part of HUIDOUBA and 10 part of 50% ethanol water, 74 ℃～78 ℃ condition refluxed 30 minutes; Be about to 1 parts by weight of crushed and drop in the extraction pot, in jar, add the ethanol water of 10 weight portions 50%, open the extraction pot heating system, make the temperature refluxed 30min of extracting solution between 74 ℃～78 ℃ to 20 purpose HUIDOUBAs.The model of said extraction pot is DC-NSG-100.
(4) adopt sucking filtration pipe on the extraction pot with 1/3rd extracting solution suction concentration tank.
(5) temperature be 68 ℃ ± 5 ℃, vacuum remain on-0.05MPA under the condition the between-0.08MPa, concentrate this extracting solution; Promptly open the straight-through and heating system of concentration tank, make that extracting solution in temperature is about 68 ℃ ± 5 ℃, vacuum remains on-0.05MPA under the condition the between-0.08MPa, concentrate this extracting solution.What this concentration tank adopted is DC-NSG-100 type concentration tank, and the steam that produces when concentrating adds step (3) as novel solvent and proceeds extracting after condensation.The steam that produces when promptly concentrating becomes condensed fluid through condensation and is back to extraction pot and does novel solvent and join and continue in the step (3) HUIDOUBA is carried out extracting; Novel solvent from top to bottom reaches the extraction pot bottom through HUIDOUBA; The novel solvent that soluble component in the HUIDOUBA is dissolved in the extraction pot forms extracting solution; Extracting solution continues to concentrate in sucking filtration pipe suction concentration tank, and the steam that produces when concentrating returns to extraction pot again and does novel solvent after condensation, repeat repeatedly until extracting liquid colourless.
(6) the spray-dried finished product that makes of extracting solution after said the concentrating, promptly this concentrated solution gets into spraying system through peristaltic pump.The model of said spraying system is DC1500.Its work process is following:
Concentrated solution sprays into drying chamber through nozzle, and compressed air gets into drying chamber from outer layer sleeve and makes liquid particleization simultaneously.Hot-air from the upper strata get into spraying after the article liquid particle meet, article liquid begins drying; Get pink powder shape finished product in the receiving flask below getting into after dried powder separates with waste gas through cyclone separator.Said pink powder shape finished product is the HUIDOUBA peptide polysaccharide.
Secondly, prepare Ramulus euonymi extract, its preparation process is following:
(1) Ramulus Euonymi behind the acquisition removal impurity.
(2) Ramulus Euonymi is crushed to fineness to 20 orders.
(3) 1KG Ramulus Euonymi and 10L water are put in the extraction pot, 100 ℃ of temperature refluxed 30 minutes.
(4) with in the extracting solution suction concentration tank.
(5) under temperature is 90 ℃, vacuum for the condition between-0.05MPa and the-0.08MPa, concentrated this extracting solution.
(6) the spray-dried Ramulus euonymi extract that makes of extracting solution after said the concentrating.
Once more, step and the condition identical according to above Ramulus euonymi extract are prepared Radix Ginseng extract, Herba Epimedii extract, radix linderae extract, Radix Aucklandiae extract, Fructus Crataegi extract, Semen Momordicae Charantiae extract and Radix Sophorae Flavescentis extract respectively.
At last, with 6 parts of HUIDOUBA peptide polysaccharides, 2 parts of Ramulus euonymi extracts; 2 parts of Radix Ginseng extracts, 2 parts of Herba Epimedii extracts, 1 part of radix linderae extract, 1 part of Radix Aucklandiae extract; 2 parts of Fructus Crataegi extracts, 2 parts of Semen Momordicae Charantiae extracts, 2 parts of oligochitosans; 1 part of mix homogeneously of Radix Sophorae Flavescentis extract is processed the ball shape through dextrin, through getting final product after polishing and the drying.The present invention can also process the dosage form of capsule, powder or tablet.
Detection method is following:
Select 105 type patients, and let it take the product that makes according to the present invention.Taking dose is: every day three times, each 10g took six months.
Its testing result is: obvious effective rate reaches 69%, and total effective rate reaches 94%.
Testing result according to above shows: the effect that the present invention treats type is remarkable, is higher than the effect of existing treatment type product far away, and takes the back effect stability, is difficult for recurrence, has no toxic and side effects.
Claims (5)
1. a compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type is characterized in that, mainly is made up of following component: the HUIDOUBA peptide polysaccharide; Ramulus euonymi extract, Radix Ginseng extract, Herba Epimedii extract; The radix linderae extract, Radix Aucklandiae extract, Fructus Crataegi extract; The Semen Momordicae Charantiae extract, oligochitosan, Radix Sophorae Flavescentis extract.
2. a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type according to claim 1 is characterized in that said compositions is made up of the component of following weight ratio: 4～8 parts of HUIDOUBA peptide polysaccharides; 1～4 part of Ramulus euonymi extract, 1～4 part of Radix Ginseng extract, 1～4 part of Herba Epimedii extract; 1～3 part of radix linderae extract, 1～3 part of Radix Aucklandiae extract, 1～4 part of Fructus Crataegi extract; 1～4 part of Semen Momordicae Charantiae extract, 1～4 part of oligochitosan, 1～3 part of Radix Sophorae Flavescentis extract.
3. a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type according to claim 2 is characterized in that said compositions is made up of the component of following weight ratio: 6 parts of HUIDOUBA peptide polysaccharides; 2 parts of Ramulus euonymi extracts, 2 parts of Radix Ginseng extracts, 2 parts of Herba Epimedii extracts; 1 part of radix linderae extract, 1 part of Radix Aucklandiae extract, 2 parts of Fructus Crataegi extracts; 2 parts of Semen Momordicae Charantiae extracts, 2 parts of oligochitosans, 1 part of Radix Sophorae Flavescentis extract.
4. according to each described a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type of claim 1～3, it is characterized in that said Ramulus euonymi extract obtains through following steps:
(1) Ramulus Euonymi behind the acquisition removal impurity;
(2) Ramulus Euonymi is crushed to fineness to 20 orders;
(3) ratio in 1Kg Ramulus Euonymi and 10L water is put in it in extraction pot, refluxes 20～30 minutes, obtains extracting solution;
(4) with extracting solution suction concentration tank;
(5) under temperature is 90 ℃, vacuum for the condition between-0.05MPa and the-0.08MPa, concentrated this extracting solution;
(6) the spray-dried Ramulus euonymi extract that makes of extracting solution after said the concentrating.
5. a kind of compositions that contains the HUIDOUBA peptide polysaccharide that is used to treat type according to claim 4; It is characterized in that the extraction step of said Radix Ginseng extract, Herba Epimedii extract, radix linderae extract, Radix Aucklandiae extract, Fructus Crataegi extract, Semen Momordicae Charantiae extract and Radix Sophorae Flavescentis extract is identical with the extraction step of Ramulus euonymi extract.
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| CN 201110374395 CN102389566B (en) | 2011-11-23 | 2011-11-23 | Huidouba peptide polysaccharide-containing composition used for treating type II diabetes |
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| CN 201110374395 CN102389566B (en) | 2011-11-23 | 2011-11-23 | Huidouba peptide polysaccharide-containing composition used for treating type II diabetes |
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| CN102389566A true CN102389566A (en) | 2012-03-28 |
| CN102389566B CN102389566B (en) | 2013-04-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105906737A (en) * | 2016-05-17 | 2016-08-31 | 华南理工大学 | Huidouba polysaccharide and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357156A (en) * | 2008-09-09 | 2009-02-04 | 田淑琴 | Traditional Chinese medicine for curing diabetes and preparation method thereof |
| CN101623389A (en) * | 2009-07-30 | 2010-01-13 | 南京中医药大学 | Drug for curing diabetes and preparation method thereof |
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2011
- 2011-11-23 CN CN 201110374395 patent/CN102389566B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357156A (en) * | 2008-09-09 | 2009-02-04 | 田淑琴 | Traditional Chinese medicine for curing diabetes and preparation method thereof |
| CN101623389A (en) * | 2009-07-30 | 2010-01-13 | 南京中医药大学 | Drug for curing diabetes and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 彭亮 等: "灰兜巴抗糖尿病作用的实验研究", 《时珍国医国药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105906737A (en) * | 2016-05-17 | 2016-08-31 | 华南理工大学 | Huidouba polysaccharide and preparation method thereof |
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Owner name: EMEISHAN HONGSHENG PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: EMEISHAN TLS PHARMACEUTICAL CO LTD |
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| CB03 | Change of inventor or designer information |
Inventor after: Lu Chengxian Inventor after: Tian Jianhong Inventor after: Che Shangze Inventor before: Yu Zemin Inventor before: Liu Fang Inventor before: Zheng Ying Inventor before: Liu Yuqin Inventor before: Liu Zhigang |
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Free format text: CORRECT: INVENTOR; FROM: YU ZEMIN LIU FANG ZHENG YING LIU YUQIN LIU ZHIGANG TO: LU CHENGXIAN TIAN JIANHONG CHE SHANGZE |
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| CP01 | Change in the name or title of a patent holder |
Address after: 614200 processing and warehousing logistics park, Hongxing Industrial Zone, victory Town, Mount Emei, Leshan, Sichuan Patentee after: Mount Emei Hong Noboru medicine company limited-liability company Address before: 614200 processing and warehousing logistics park, Hongxing Industrial Zone, victory Town, Mount Emei, Leshan, Sichuan Patentee before: Emeishan TLS Pharmaceutical Co., Ltd. |
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| C53 | Correction of patent of invention or patent application | ||
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Inventor after: Yu Zemin Inventor after: Liu Fang Inventor after: Zheng Ying Inventor after: Liu Yuqin Inventor after: Liu Zhigang Inventor before: Lu Chengxian Inventor before: Tian Jianhong Inventor before: Che Shangze |
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Free format text: CORRECT: INVENTOR; FROM: LU CHENGXIAN TIAN JIANHONG CHE SHANGZE TO: YU ZEMIN LIU FANG ZHENG YING LIU YUQIN LIU ZHIGANG |