CN105106704A - Traditional Chinese medicine composite and traditional Chinese medicine composite dissolved medicine for preventing and treating diabetes, and preparing methods of traditional Chinese medicine composite and traditional Chinese medicine composite dissolved medicine - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composite and traditional Chinese medicine composite dissolved medicine for preventing and treating diabetes, and preparing methods of the traditional Chinese medicine composite and traditional Chinese medicine composite dissolved medicine. The composite is prepared from, by mass, 5-10 parts of gynura bicolor extracts, 5-10 parts of purple lythrum herb extracts, 3-5 parts of cymbopogon distans, 3-5 parts of huidouba, 2-8 parts of capcjasmine, 3-10 parts of radix paeoniae alba, 3-5 parts of heterophyllous wing seedtreeroots, 3-5 parts of radix polygoni multiflori, 2-3 parts of dragon bones, 3-5 parts of gorgon euryale seeds, 2 parts of diversecolor cinquefoil, 2 parts of semen cuscutae, 2 parts of stevia rebaudiana, 2 parts of corn stigmas, 2 parts of whorledleaf solomonseal rhizome, 2 parts of kudzu vine roots, 3 parts of radix trichosanthes, 2 parts of semen cassia, 2 parts of silkworm cocoons, 3 parts of poria cocos, 2 parts of textile screw pine seeds, 2 parts of asiatic striga, and 1 part of astragalus membranaceus which serve as main materials, and 0.05-0.1 part of soy isoflavone, 0.05-0.1 part of soyasaponin, 0.5-1 part of amino acid, 0.2-0.3 part of yeast, 0.1 part of vitamin A, 0.1 part of vitamin C, 0.05 part of xylitol and 0.05 part of mannitol crystal which serve as auxiliary materials.

Description

The Chinese medicine complex composition, electuary and preparation method thereof of prophylactic treatment diabetes

Technical field

The present invention relates to medical art, specifically relate to a kind of Chinese medicine complex composition, electuary and preparation method thereof of prophylactic treatment diabetes.

Background technology

Diabetes with thirsty polydipsia, receive food increase, hydrouria, body constitution and become thin, lose weight as cardinal symptom, be commonly called as " three-many-one-little ", in clinical, also with or without " three-many-one-little " symptom.Because free insulin in blood and bound insulin increase, anti-insulin principle short of money increases, and the change of insulin synthesis character, cause increasing of blood glucose, glucose in urine, the traditional Chinese medical science is called diabetes, is divided into: upper, middle and lower three disappear.This disease has a strong impact on the quality of life of patient.Current existing western medical treatment is primary treatments mainly with long-term taking antidiabetic drug, insulin injection, but drug side effect is large, and late result is not good, and medical expense is higher, brings very large misery and financial burden to patient and family members.

Diabetes are a kind of common endocrinopathyes, the traditional Chinese medical science is referred to as " quenching one's thirst ", that in blood that is absolute due to insulin in human body or that relatively lack and cause, concentration of glucose raises, sugar is discharged in a large number from urine, and the phenomenon occurring polydipsia, polyuria, polyphagia and weight loss, become thin, diabetes are once make a definite diagnosis and will take medicine all the life.

Diabetes are after cardiovascular and cerebrovascular disease, malignant tumor, the 3rd killer of harm humans health.Statistics according to 13 research centers such as World Health Organization (WHO) (WHO), IDF (IDF) and ADAs (ADA) shows, current global diabetics has reached 2.5 hundred million people, and wherein the patient of 20% (5,000 ten thousand) is in China.In China's present stage, along with the raising of living standards of the people, food quality also improves greatly, but due to dietary structure and custom unreasonable and take exercise seldom, the number suffering from diabetes sharply increases, the sickness rate of diabetes in 1980 only has 1%, and have 5% up till now, the onset diabetes rate of economically developed Beijing, District of Shanghai reaches 8% and 11% even respectively.According to authoritative institution's prediction, about 6,000 ten thousand people being reached to the diabetics of China in 2010.

At present, the antihypelipidemic product market of China is based on Western medicine, although Western medicine effect is comparatively obvious, the drug resistance that Long-term taking medicine causes, Drug resistance, lesions of liver and kidney etc., allow diabetics fully feel misery; And the medicine of Chinese medicine blood sugar lowering class, the general blood sugar reducing function of food are not obvious.There is investigation display: diabetics is to existing treatment, stabilizing blood sugar effect, urgent to the product demand of human non-toxic's side effect again.

Up to now, had a lot about the application of Chinese medicine in diabetes, such as Chinese patent CN103989988A discloses a kind of Chinese medicine composition of adjuvant therapy of diabetes.Chinese patent CN103948748A discloses a kind of Chinese medicine for the treatment of diabetes.But because cost is high, DeGrain is not all well promoted, in order to overcome these problems existing, propose the present invention.

Summary of the invention

In order to plug a gap, a kind of Chinese medicine complex composition of prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By dry dish of bending under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

A kind of preparation method of Chinese medicine complex composition of prophylactic treatment diabetes:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min (preferred 25min);

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae leaf boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature.

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure concentrates

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; By take Herba Cymbopogonis, HUIDOUBA, Fructus Gardeniae, the Radix Paeoniae Alba, Radix Pterospermi Heterophylli, the Radix Polygoni Multiflori, Os Draconis, Semen Euryales, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali;

To 160 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The soybean isoflavone taken, soybean saponin, aminoacid, yeast, vitamin A, vitamin C, xylitol, crystallization of mannitol;

Mix with the mixed dust formulation that step 2 obtains, then stir evenly evenly.

A Chinese medicine complex composition electuary for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant one is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Adjuvant two is,

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

A preparation method for the Chinese medicine complex composition electuary of prophylactic treatment diabetes, step is as follows:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant one is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part; Adjuvant two is:

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; To 230 orders after the Semen Euryales taken, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali being pulverized respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The adjuvant one taken; The mixed dust formulation that the adjuvant two and the step 2 that take obtain mixes, and then stirs evenly evenly stand-by;

Mixed dust formulation described in step (three) stirs evenly by (step 4), sterilizing, pack, packaging.

Preferably, sterilizing described in step 4 adopts ultraviolet radiation sterilizing in 30-40 minute.

Preferably, sterilizing described in step 4 adopts the sterilizing in 35 minutes of LED ultra violet lamp.

Beneficial effect

It is blank that the present invention fills up application, design for vast " three-hypers " epilepsy patient in rising trend, the extract that have employed the medicine such as Radix seu Folium Alchorneae trewioidis, Herba Lythri Salicariae, according to Traditional Chinese Medicine tcm theory, is processed into through scientific process, prescription and production technology science, rationally; Be easy to take, evident in efficacy; All be integration of edible and medicinal herbs containing plant material and be safety, stable, effective through long-term practice, facilitating patient's life-time service, have no side effect, is that a kind of desirable product with blood sugar reducing function also can make medicine according to relevant laws and regulations.

Detailed description of the invention

Describe the present invention in detail below in conjunction with specific embodiment and clinical trial example, better embodied to make its advantage.

Embodiment 1:

A Chinese medicine complex composition for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5 parts, lythrum salucaria 5 parts, Herba Cymbopogonis 3 parts, HUIDOUBA 3 parts, Fructus Gardeniae 2 parts, the Radix Paeoniae Alba 3 parts, Radix Pterospermi Heterophylli 3 parts, the Radix Polygoni Multiflori 3 parts, Os Draconis 2 parts, Semen Euryales 3 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.05 part, soybean saponin 0.05 part, 0.5 part, aminoacid, yeast 0.2-part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

A kind of preparation method of Chinese medicine complex composition of prophylactic treatment diabetes:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5 parts, lythrum salucaria 5 parts, Herba Cymbopogonis 3 parts, HUIDOUBA 3 parts, Fructus Gardeniae 2 parts, the Radix Paeoniae Alba 3 parts, Radix Pterospermi Heterophylli 3 parts, the Radix Polygoni Multiflori 3 parts, Os Draconis 2 parts, Semen Euryales 3 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.05 part, soybean saponin 0.05 part, 0.5 part, aminoacid, 0.2 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min (preferred 25min);

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae leaf boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature.

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure concentrates

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; By take Herba Cymbopogonis, HUIDOUBA, Fructus Gardeniae, the Radix Paeoniae Alba, Radix Pterospermi Heterophylli, the Radix Polygoni Multiflori, Os Draconis, Semen Euryales, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali;

To 160 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The soybean isoflavone taken, soybean saponin, aminoacid, yeast, vitamin A, vitamin C, xylitol, crystallization of mannitol;

Mix with the mixed dust formulation that step 2 obtains, then stir evenly evenly.

A Chinese medicine complex composition electuary for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant one is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Adjuvant two is,

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

A preparation method for the Chinese medicine complex composition electuary of prophylactic treatment diabetes, step is as follows:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5 parts, lythrum salucaria 5 parts, Herba Cymbopogonis 3 parts, HUIDOUBA 3 parts, Fructus Gardeniae 2 parts, the Radix Paeoniae Alba 3 parts, Radix Pterospermi Heterophylli 3 parts, the Radix Polygoni Multiflori 3 parts, Os Draconis 2 parts, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant one is,

Soybean isoflavone 0.05 part, soybean saponin 0.05 part, 0.5 part, aminoacid, 0.2 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part; Adjuvant two is:

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; To 230 orders after the Semen Euryales taken, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali being pulverized respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The adjuvant one taken; The mixed dust formulation that the adjuvant two and the step 2 that take obtain mixes, and then stirs evenly evenly stand-by;

Mixed dust formulation described in step (three) stirs evenly by (step 4), sterilizing, pack, packaging.

Preferably, sterilizing described in step 4 adopts ultraviolet radiation sterilizing in 30-40 minute.

Preferably, sterilizing described in step 4 adopts the sterilizing in 35 minutes of LED ultra violet lamp.

Embodiment 2

A Chinese medicine complex composition for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 7.5 parts, lythrum salucaria 7.5 parts, Herba Cymbopogonis 4 parts, HUIDOUBA 4 parts, Fructus Gardeniae 5 parts, the Radix Paeoniae Alba 6.5 parts, Radix Pterospermi Heterophylli 4 parts, the Radix Polygoni Multiflori 4 parts, Os Draconis 2.5 parts, Semen Euryales 4 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.075 part, soybean saponin 0.075 part, 0.75 part, aminoacid, 0.25 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

A kind of preparation method of Chinese medicine complex composition of prophylactic treatment diabetes:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 7.5 parts, lythrum salucaria 7.5 parts, Herba Cymbopogonis 4 parts, HUIDOUBA 4 parts, Fructus Gardeniae 5 parts, the Radix Paeoniae Alba 6.5 parts, Radix Pterospermi Heterophylli 4 parts, the Radix Polygoni Multiflori 4 parts, Os Draconis 2.5 parts, Semen Euryales 4 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.075 part, soybean saponin 0.075 part, 0.75 part, aminoacid, 0.25 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min (preferred 25min);

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae leaf boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature.

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure concentrates

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; By take Herba Cymbopogonis, HUIDOUBA, Fructus Gardeniae, the Radix Paeoniae Alba, Radix Pterospermi Heterophylli, the Radix Polygoni Multiflori, Os Draconis, Semen Euryales, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali;

To 160 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The soybean isoflavone taken, soybean saponin, aminoacid, yeast, vitamin A, vitamin C, xylitol, crystallization of mannitol;

Mix with the mixed dust formulation that step 2 obtains, then stir evenly evenly.

A Chinese medicine complex composition electuary for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 7.5 parts, lythrum salucaria 7.5 parts, Herba Cymbopogonis 4 parts, HUIDOUBA 4 parts, Fructus Gardeniae 5 parts, the Radix Paeoniae Alba 6.5 parts, Radix Pterospermi Heterophylli 4 parts, the Radix Polygoni Multiflori 4 parts, Os Draconis 2.5 parts, Semen Euryales 4 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.075 part, soybean saponin 0.075 part, 0.75 part, aminoacid, 0.25 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Adjuvant two is,

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

A preparation method for the Chinese medicine complex composition electuary of prophylactic treatment diabetes, step is as follows:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 7.5 parts, lythrum salucaria 7.5 parts, Herba Cymbopogonis 4 parts, HUIDOUBA 4 parts, Fructus Gardeniae 5 parts, the Radix Paeoniae Alba 6.5 parts, Radix Pterospermi Heterophylli 4 parts, the Radix Polygoni Multiflori 4 parts, Os Draconis 2.5 parts, Semen Euryales 4 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.075 part, soybean saponin 0.075 part, 0.75 part, aminoacid, 0.25 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part; Adjuvant two is:

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; To 230 orders after the Semen Euryales taken, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali being pulverized respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The adjuvant one taken; The mixed dust formulation that the adjuvant two and the step 2 that take obtain mixes, and then stirs evenly evenly stand-by;

Mixed dust formulation described in step (three) stirs evenly by (step 4), sterilizing, pack, packaging.

Preferably, sterilizing described in step 4 adopts ultraviolet radiation sterilizing in 30-40 minute.

Preferably, sterilizing described in step 4 adopts the sterilizing in 35 minutes of LED ultra violet lamp.

Embodiment 3

A Chinese medicine complex composition for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 10 parts, lythrum salucaria 10 parts, Herba Cymbopogonis 5 parts, HUIDOUBA 5 parts, Fructus Gardeniae 8 parts, the Radix Paeoniae Alba 10 parts, Radix Pterospermi Heterophylli 5 parts, the Radix Polygoni Multiflori 5 parts, Os Draconis 3 parts, Semen Euryales 5 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.1 part, soybean saponin 0.1 part, amino acid/11 part, 0.3 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

A kind of preparation method of Chinese medicine complex composition of prophylactic treatment diabetes:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 10 parts, lythrum salucaria 10 parts, Herba Cymbopogonis 5 parts, HUIDOUBA 5 parts, Fructus Gardeniae 8 parts, the Radix Paeoniae Alba 10 parts, Radix Pterospermi Heterophylli 5 parts, the Radix Polygoni Multiflori 5 parts, Os Draconis 3 parts, Semen Euryales 5 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.1 part, soybean saponin 0.1 part, amino acid/11 part, 0.3 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min (preferred 25min);

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae leaf boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature.

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure concentrates

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; By take Herba Cymbopogonis, HUIDOUBA, Fructus Gardeniae, the Radix Paeoniae Alba, Radix Pterospermi Heterophylli, the Radix Polygoni Multiflori, Os Draconis, Semen Euryales, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali;

To 160 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The soybean isoflavone taken, soybean saponin, aminoacid, yeast, vitamin A, vitamin C, xylitol, crystallization of mannitol;

Mix with the mixed dust formulation that step 2 obtains, then stir evenly evenly.

A Chinese medicine complex composition electuary for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 10 parts, lythrum salucaria 10 parts, Herba Cymbopogonis 5 parts, HUIDOUBA 5 parts, Fructus Gardeniae 8 parts, the Radix Paeoniae Alba 10 parts, Radix Pterospermi Heterophylli 5 parts, the Radix Polygoni Multiflori 5 parts, Os Draconis 3 parts, Semen Euryales 5 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.1 part, soybean saponin 0.1 part, amino acid/11 part, 0.3 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Adjuvant two is,

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

A preparation method for the Chinese medicine complex composition electuary of prophylactic treatment diabetes, step is as follows:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 10 parts, lythrum salucaria 10 parts, Herba Cymbopogonis 5 parts, HUIDOUBA 5 parts, Fructus Gardeniae 8 parts, the Radix Paeoniae Alba 10 parts, Radix Pterospermi Heterophylli 5 parts, the Radix Polygoni Multiflori 5 parts, Os Draconis 3 parts, Semen Euryales 5 parts, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.1 part, soybean saponin 0.1 part, amino acid/11 part, 0.3 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Adjuvant two is:

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; To 230 orders after the Semen Euryales taken, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali being pulverized respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The adjuvant one taken; The mixed dust formulation that the adjuvant two and the step 2 that take obtain mixes, and then stirs evenly evenly stand-by;

Mixed dust formulation described in step (three) stirs evenly by (step 4), sterilizing, pack, packaging.

Preferably, sterilizing described in step 4 adopts ultraviolet radiation sterilizing in 30-40 minute.

Preferably, sterilizing described in step 4 adopts the sterilizing in 35 minutes of LED ultra violet lamp.

Clinical trial example

The electuary composition properties and characteristics that the present invention relates to is taupe, powdery, has fragrant and sweet taste, soluble in water.Show through safety toxicology test: LD50 is 20000mg/kg, and Toxicological evaluation is nontoxic level, has no side effect.

1. clinical application effect statistics:

Randomly draw diabetics 200 example of certain hospital in January, 2012 to 2013 year December clinical age of accepting for medical treatment more than 50 years old, wherein male patient 138 example, female patient 62 example.Patient all suffers from diabetic symptom, the shortest person 3 years, and most elder 18 years, average course of disease was in 10 years.Curative effect after electuary of the present invention is taken to above-mentioned 200 routine patients and carries out tracing observation record:

Good blood sugar lowering, lipid-lowering effect are also obtained to 200 hyperglycemic patients; After experimenter drinks 30 days, TC on average declines 1.18mmol/L, HDL raises 0.83mmol/L, wherein obviously decline TC and the effect raising HDL, its effect is higher than vitamin E, the average rate of decrease playing its glucose is 12.2%, and the average rate of decrease of fructosamine is check its blood glucose value all to reach normal level after 21.5%, 30 days.Result of the test shows: the curative effect of medication that the present invention relates to is remarkable.

Patient one: Lee, man, 65 years old.Suffer from diabetes 6 years, lower limbs edema complication, repeatedly increase the weight of without improvement through Drug therapy for many years, in June, 2012 is admitted to hospital.Take this medicine after 7 days, remission, continue to take this medicine after 14 days, symptom takes a turn for the better gradually, and lower limbs edema obviously disappears, and after taking 30 days, blood glucose is basicly stable.

Patient two: Wang, male, 58 years old, suffer from diabetes 7 years, and visual deterioration is severe, and in July, 2013 is admitted to hospital, and take this medicine after 14 days, disease amelioration, vision makes moderate progress, and take this medicine after 28 days, vision significantly improves.

Show through pharmacological testing: this medicine has effect of blood fat reducing, blood sugar lowering.Obvious effect is had to hyperglycemia, hyperlipidemia.

The raw material of this product can make full use of the resource of artificial growth, and its raw material resources abundance is guaranteed, and production cost is low, efficiency is high, economic benefit, social benefit are remarkable.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (4)

1. a Chinese medicine complex composition for prophylactic treatment diabetes, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

2. the preparation method of the Chinese medicine complex composition of a kind of prophylactic treatment diabetes according to claim 1:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min (preferred 25min);

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae leaf boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature.

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure concentrates

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; By take Herba Cymbopogonis, HUIDOUBA, Fructus Gardeniae, the Radix Paeoniae Alba, Radix Pterospermi Heterophylli, the Radix Polygoni Multiflori, Os Draconis, Semen Euryales, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali;

To 160 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The soybean isoflavone taken, soybean saponin, aminoacid, yeast, vitamin A, vitamin C, xylitol, crystallization of mannitol;

Mix with the mixed dust formulation that step 2 obtains, then stir evenly evenly.

3. the Chinese medicine complex composition electuary of a kind of prophylactic treatment diabetes according to claim 1-2, as follows by mass parts component:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant one is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, yeast 0.2-0.3 part, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part;

Adjuvant two is,

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

4. the preparation method of the Chinese medicine complex composition electuary of a kind of prophylactic treatment diabetes according to claim 3, step is as follows:

(step one) is as follows by taking component by mass parts:

Major ingredient is,

Radix seu Folium Alchorneae trewioidis extract 5-10 part, lythrum salucaria 5-10 part, Herba Cymbopogonis 3-5 part, HUIDOUBA 3-5 part, Fructus Gardeniae 2-8 part, Radix Paeoniae Alba 3-10 part, Radix Pterospermi Heterophylli 3-5 part, Radix Polygoni Multiflori 3-5 part, Os Draconis 2-3 part, Semen Euryales 3-5 part, Herba Potentillae Discoloris 2 parts, Semen Cuscutae 2 parts, Folium Stevlae Rebaudianae 2 parts, Stigma Maydis 2 parts, Rhizoma Polygonati Verticillati 2 parts, Radix Puerariae 2 parts, radices trichosanthis 3 parts, Semen Cassiae 2 parts, Bombyx bombycis 2 parts, 3 parts, Poria, Fructus Pandani tectorii 2 parts, Herba Strigae Asiaticae 2 parts, the Radix Astragali 1 part;

Adjuvant one is,

Soybean isoflavone 0.05-0.1 part, soybean saponin 0.05-0.1 part, aminoacid 0.5-1 part, 0.2 ~ 0.3 part, yeast, vitamin A 0.1 part, vitamin C 0.1 part, xylitol 0.05 part, crystallization of mannitol 0.05 part; Adjuvant two is:

Xylitol, mannitol or Oligomeric maltose be two or more mixing 2-3 part wherein,

Tertiary sodium phosphate, aspartame, Mint Essence or Oleum menthae be two or more mixing 2-3 part wherein,

Mixture 1-2 part of magnesium stearate and silica white, (by weight) mixed proportion is 1: 1,

One in cross-linking sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose 1 part.

Described Poria is through following pretreatment: by the Poria peeling after cleaning, add after adopting first 88 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of water making beating, add the α-amylase of 1.5 ~ 2%, liquefy under 60 ~ 70 DEG C of conditions 20 ~ 30min;

Described Radix seu Folium Alchorneae trewioidis extract adopts following steps to extract:

(1) with the Radix seu Folium Alchorneae trewioidis that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;

(2), after clean Radix seu Folium Alchorneae trewioidis being drained or dried, wall cell disruption powder is broken into Radix seu Folium Alchorneae trewioidis coarse powder;

(3) by the water-cooled leaching 12 ~ 24 hours of Radix seu Folium Alchorneae trewioidis coarse powder;

(4) enzymolysis

1) Radix seu Folium Alchorneae trewioidis adjusting PH with base 7-8, adds cellulase 15 ~ 30U by every gram of Radix seu Folium Alchorneae trewioidis raw material, enzymolysis 2 hours at the temperature of 40 ~ 50 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;

2) add 3 ~ 5 weight parts waters in Radix seu Folium Alchorneae trewioidis filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;

3) add 3 ~ 5 weight parts waters in the filtering residue b of Radix seu Folium Alchorneae trewioidis, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;

4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;

(5) concentrating under reduced pressure

By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Radix seu Folium Alchorneae trewioidis extract;

Described lythrum salucaria adopts following steps to extract::

1. Herba Lythri Salicariae cuts into broken leaf;

2. broken Herba Lythri Salicariae boiled water spray is carried out sterilizing, sterilizing;

3. water logging enzymolysis:

The broken Herba Lythri Salicariae drained the water by spray drops in retort, add the cellulase solution containing alkali pH8, throw enzyme amount and add cellulase 15U by weight every gram of Herba Lythri Salicariae, continue again add compacting after mix homogeneously after to add, every layer is sprayed cellulase solution and is as the criterion with moistening, finally add the compacting of full enzymatic solution, enzymolysis 10 ~ 15 hours at 40 ~ 50 DEG C of temperature;

4. alcohol extraction

Drop into ethanol, Herba Lythri Salicariae and concentration 75 ~ 80% proportion of ethanol are 1: 12 ~ 17 weight portions, extract 4 ~ 8 hours, then use percolation percolation at 65 ~ 70 DEG C of temperature;

5. recycling design

Alcohol extraction liquid and percolation cleanout fluid are put in ethanol recycling can, reclaims ethanol at 78 ~ 80 DEG C, obtain Herba Lythri Salicariae solution;

6. concentrating under reduced pressure

By Herba Lythri Salicariae under the condition of steam pressure≤0.15Mpa, vacuum 700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste lythrum salucaria.

(step 2) selects commercially available super micron mill; To 230 orders after the Semen Euryales taken, Herba Potentillae Discoloris, Semen Cuscutae, Folium Stevlae Rebaudianae, Stigma Maydis, Rhizoma Polygonati Verticillati, Radix Puerariae, radices trichosanthis, Semen Cassiae, Bombyx bombycis, Fructus Pandani tectorii, Herba Strigae Asiaticae, the Radix Astragali being pulverized respectively by superfine powder machine, be then mixed to get mixed dust formulation stand-by;

Radix seu Folium Alchorneae trewioidis extract, lythrum salucaria, Poria that (step 3) will obtain in step one by said ratio; The adjuvant one taken; The mixed dust formulation that the adjuvant two and the step 2 that take obtain mixes, and then stirs evenly evenly stand-by;

Mixed dust formulation described in step (three) stirs evenly by (step 4), sterilizing, pack, packaging.