CN102389511B - Anti-radiation Chinese medicine preparation and preparation method thereof - Google Patents
Anti-radiation Chinese medicine preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an anti-radiation Chinese medicine preparation and a preparation method thereof. The preparation is a capsule which is prepared by mixing extract powder of a Chinese medicine composition and microcrystalline cellulose with the weight ratio of 2:1, wherein the Chinese medicine composition consists of ingredients according to parts by weight: 160-200 parts of astragalus mongholicus, 110-130 parts of fructus psoraleae, 80-100 parts of angelica sinensis, 160-200 parts of herba epimedii, 135-165 parts of madder root, 110-130 parts of fructus ligustri lucidi, 110-130 parts of radix paeoniae alba, 110-130 parts of radix rehmanniae preparata, 80-100 parts of ligusticum wallichii, 215-265 parts of rhizoma dioscoreae and 35-45 parts of radix glycyrrhizae preparata, and the extract powder is dry powder of ethanol solution extract of the Chinese medicine composition. The anti-radiation Chinese medicine preparation is precise in anti-radiation treatment effect, low in toxicside effects, simple in preparation method, low in cost, convenient to carry, easy to store, convenient to take and accurate in dosage, thus having good development and application prospect in the prevention and treatment of radiation injury.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of Chinese medicine preparation, also relate to the preparation method of said preparation.
Background technology
Along with the development of modern times nuclear military technology, soldier is subjected to the threat of radioprotective increasing, and the realistic possibility that the terrorist utilizes nuclear loading amount, nuclear material or radioactive substance to carry out the terrorism destructive activity also heightens day by day.Problems such as the greenhouse effect that produces in the face of the energy crisis of increasingly sharpening at present and fossil energy utilization, environmental pollution; nuclear energy is as a kind of cleaning, the energy efficiently, and it also is the developing direction of energy industry in following long one period that peaceful development utilizes nuclear energy.In addition, the use of armarium such as nuclear magnetic resonance, NMR, isotope, medical X-ray has also increased the probability of medical personnel and patient's raying harm.Therefore, radiation problem has become the topic that the whole society and various countries army show great attention to.The development of the antiradiation drug that determined curative effect, side effect are low, cheap; for the officers and men of army and other related personnel that are operated under the radiation environment; the personal protection of the public contingent even that causes because of nuclear war and nuclear leakage, and the patient is low because of the immunity of organisms that radiotherapy causes, hemopoietic function is unusual etc., and radiation damage all has very important meaning.
Be used for radiation-resistant medicine at present and mainly contain 4 classes: cytokine, sulfur-containing compound, natural plants, hormones; Radioprotective mechanism mainly contains 4 aspects: be activity level to the protection of hemopoietic system, to immune protection, anti-radical action, raising body defensive ferment.Wherein, the cytokine therapy prospect better but the expense costliness; Sulfur-containing compound and hormones toxic and side effects are bigger, are unfavorable for prophylactic.In recent years, domestic radiation resistance research to Chinese medicine increases, single medicinal material research is more the Radix Astragali, Radix Angelicae Sinensis, Radix Rhodiolae, the Radix Polygoni Multiflori, Fructus Lycii, Radix Notoginseng, Radix Bupleuri, Semen sojae atricolor, spirulina, a pollen etc., and herbal mixture research is more SIWU TANG, BAZHEN TANG, improve people's living condition and set upright liquid, rise blood soup etc.
Summary of the invention
In view of this, one of purpose of the present invention is to provide a kind of Chinese medicine preparation with radiation resistance, determined curative effect, toxic and side effects be low, with low cost, easy to carry, be easy to preserve, be convenient to take, dosage is accurate, thereby provide more, better drug candidate for the prevention of the clinical treatment after the radiation damage and radiation damage.
For achieving the above object, radioprotective Chinese medicine preparation provided by the invention is the capsule that is made after mix for 2:1 by the extract powder of Chinese medicine composition and microcrystalline Cellulose, and described Chinese medicine composition is composed of the following components by weight: Radix Astragali 160-200 part, Fructus Psoraleae 110-130 part, Radix Angelicae Sinensis 80-100 part, Herba Epimedii 160-200 part, Radix Rubiae 135-165 part, Fructus Ligustri Lucidi 110-130 part, Radix Paeoniae Alba 110-130 part, Radix Rehmanniae Preparata 110-130 part, Rhizoma Chuanxiong 80-100 part, Rhizoma Dioscoreae 215-265 part, Radix Glycyrrhizae Preparata 35-45 part; The xeraphium of the alcoholic solution extract that described extract powder is described Chinese medicine composition.
Preferably, described Chinese medicine composition is composed of the following components by weight: Radix Astragali 170-190 part, Fructus Psoraleae 115-125 part, Radix Angelicae Sinensis 85-95 part, Herba Epimedii 170-190 part, Radix Rubiae 142-157 part, Fructus Ligustri Lucidi 115-125 part, Radix Paeoniae Alba 115-125 part, Radix Rehmanniae Preparata 115-125 part, Rhizoma Chuanxiong 85-95 part, Rhizoma Dioscoreae 230-250 part, Radix Glycyrrhizae Preparata 38-42 part.
Preferred, described Chinese medicine composition is composed of the following components by weight: 180 parts of the Radixs Astragali, 120 parts of Fructus Psoraleaes, 90 parts of Radix Angelicae Sinensis, 180 parts of Herba Epimedii, 150 parts of Radix Rubiae, 120 parts of Fructus Ligustri Lucidi, 120 parts of the Radix Paeoniae Albas, 120 parts in Radix Rehmanniae Preparata, 90 parts of Rhizoma Chuanxiongs, 240 parts of Rhizoma Dioscoreaes, 40 parts of Radix Glycyrrhizae Preparatas.
Preferably, described extract powder is to be that 75% alcoholic solution extracts extract obtained xeraphium with described Chinese medicine composition volume fraction.
Two of purpose of the present invention is to provide a kind of preparation method of described radioprotective Chinese medicine preparation, and is easy and simple to handle, and cost is low, constant product quality.
For achieving the above object, the preparation method of radioprotective Chinese medicine preparation provided by the invention comprises following steps:
A. get Chinese medicine composition, be ground into fine powder, extract 2 ~ 3 times with alcoholic solution, extracting solution reclaims solvent to the thick paste shape, and drying under reduced pressure powdered again makes the extract powder of Chinese medicine composition;
B. with the extract powder of the Chinese medicine composition of step a gained and microcrystalline Cellulose by weight for 2:1 mixes, be wetting agent soft material processed with the alcoholic solution, granulation, drying, granulate, the capsulae vacuus of packing into namely gets the radioprotective Chinese medicine preparation.
Preferably, described step a is to be 75% alcoholic solution reflux, extract, 2 times with volume fraction, each 2 hours; Described step b is to be that 95% alcoholic solution is wetting agent with volume fraction.
Beneficial effect of the present invention is: the invention provides a kind of radioprotective Chinese medicine preparation, be the extract with Chinese medicine composition of radiation resistance be that active component, microcrystalline Cellulose are the capsule that adjuvant makes, said preparation can raise
60Thymus index and the index and spleen index of Co gamma-radiation mice, the protection immune organ; Can improve
60Superoxide dismutase activity in Co gamma-radiation mice serum and the liver reduces mda content, improves the oxidation resistance of body; Can raise
60Co gamma-radiation mice peripheral blood leucocyte is improved hemopoietic function; Can reduce
60The bone marrow cell micronucleus rate of Co gamma-radiation mice suppresses
60Co is gamma-ray to cause the chromosomal aberration effect; In addition, this Chinese medicine preparation toxic and side effects is low, and preparation method is simple, and is with low cost, easy to carry, is easy to preserve, and is convenient to take, and dosage is accurate; Therefore; has the excellent development application prospect aspect prevention and the treatment radiation damage; can be used for radiation damagies such as the immunity of organisms that radiotherapy causes is low, hemopoietic function is unusual; can be the officers and men of army that are operated under the radiation environment and other related personnel provides and special procures medicine, also can be under the high-tech modern war condition and the personal protection of the public contingent even that radiation causes provides material to stock.
The specific embodiment
In order to make the purpose, technical solutions and advantages of the present invention clearer, below the preferred embodiments of the present invention are described in detail.
The preparation of embodiment 1, radioprotective Chinese medicine preparation
Preparation method: measure 11 flavor medical materials such as the Radix Astragali by prescription, be ground into fine powder, adding 8 times of amount volume fractions is 70% alcoholic solution, reflux, extract, 2 hours extracts twice, merge extractive liquid, altogether, filter, filtrate is reclaimed solvent to the thick paste shape, and drying under reduced pressure powdered again makes the extract powder of Chinese medicine composition; By weight be the 2:1 mixing, be 95% alcoholic solution processed soft material with volume fraction with the extract powder of gained Chinese medicine composition and microcrystalline Cellulose, No. 2 sieve series grains, 60 ℃ of oven dry are sieved granulate No. 2, and the capsulae vacuus of packing into is made 1500, namely.
Find in the experimentation that the viscosity of the extract powder of gained Chinese medicine composition is stronger, be easy to caking, flowability is poor, directly filled capsules.In order to reduce the hygroscopicity of extract powder, increase stability, the present invention is the index screening adjuvant with angle of repose, hydroscopicity, critical relative humidity, bulk density etc., found that, when extract powder and microcrystalline Cellulose when be the 2:1 proportioning, the flowability of gained material and hydroscopicity are with respect to adopting other adjuvant such as starch, dextrin etc. to get well, and the uniform particles afterwards of granulating, mobile further improvement, the disintegrative of gained capsule is also good.Because viscosity is very big after the moisture absorption of extract powder, need not to use binding agent, directly make wetting agent with alcoholic solution and can granulate, be that 95% alcoholic solution is better as the shaping particles that wetting agent makes with volume fraction wherein.In addition, the critical relative humidity of gained capsule is about 70%, and prompting should control environment relative humidity aborning below 70%, in order to avoid influence the quality of product.
The pharmacodynamic study of embodiment 2, radioprotective Chinese medicine preparation
Get the Kunming mouse of age in 8-10 week, body weight 18-20g, be divided into the normal control group at random, radiation model group, the high, medium and low dosage group of radioprotective Chinese medicine preparation and positive drug group (DIYU SHENGBAI PIAN group or beneficial blood are given birth to Capsules group), 10 every group.Normal control group and radiation model group are irritated the stomach normal saline, and the high, medium and low dosage group of radioprotective Chinese medicine preparation is irritated stomach according to the embodiment 1 prescription 3 capsule 's content solution that make, and the positive drug group is irritated stomach relative medicine solution.After 7 days, except normal control group mice, all the other are respectively organized mice and carry out
60Co gamma-radiation, dosage are 5Gy.After the irradiation, each group continues to irritate the corresponding solution of stomach.
1, to Immune Effects
Immunity is extremely sensitive to radiation damage, and radiation effects can make each ingredient of immune system the inhibition effect occur in body.
Get
60Behind the Co gamma-radiation 7 days respectively organize mice, weigh, eye socket is got blood and is put to death, divide and get thymus and spleen, weigh, calculate thymus index and index and spleen index respectively by following formula: thymus index=thymic weight (mg)/mice weight (g), index and spleen index=spleen weight (mg)/mice weight (g), each organize data with means standard deviation (
) expression.The results are shown in Table 1, thymus index and the index and spleen index of radiation model group mice all are lower than the normal control group, and difference has significance (p＜0.01); The radioprotective Chinese medicine preparation can raise
60Thymus index and the index and spleen index of Co gamma-radiation mice have been compared significant difference (p＜0.05) with the radiation model group, illustrate that the radioprotective Chinese medicine preparation has protective effect to immune organ.
Table 1 radioprotective Chinese medicine preparation is right
60The influence of Co gamma-radiation mouse thymus index, index and spleen index
* represent to compare with the normal control group,
p＜0.05; * represents to compare with the normal control group,
p＜0.01;
# represents to compare with the radiation model group,
p＜0.05; ## represents to compare with the radiation model group,
p＜0.01.
2, to the influence of oxidation resistance
Superoxide dismutase (SOD), malonaldehyde (MDA) and glutathion peroxidase (GSH-px) are the important indicators of estimating antioxidant ability of organism.
Get
60Behind the Co gamma-radiation 7 days respectively organize mice, weigh, eye socket is got blood and is put to death, and divides and gets serum, preparation liver homogenate supernatant is measured SOD, MDA, the content of GSH-px in serum and liver with reference to SOD, MDA, GSH-px test kit description.The results are shown in Table 2-3, the SOD activity is compared obvious reduction with the normal control group in radiation model group mice serum and the liver, MDA content then obviously raises, difference has significance (p＜0.01), radioprotective Chinese medicine preparation group SOD in Mice value is apparently higher than the radiation model group, MDA content then obviously reduces, and difference has significance (p＜0.01), illustrates that the radioprotective Chinese medicine preparation can improve antioxidant ability of organism.
Table 2 radioprotective Chinese medicine preparation is right
60The influence of SOD, MDA, GSH-px in the Co gamma-radiation mice serum
* represent to compare with the normal control group,
p＜0.05; * represents to compare with the normal control group,
p＜0.01;
# represents to compare with the radiation model group,
p＜0.05; ## represents to compare with the radiation model group,
p＜0.01.
Table 3 radioprotective Chinese medicine preparation is right
60The influence of SOD, MDA, GSH-px in the Co gamma-radiation mouse liver even slurry
* represent to compare with the normal control group,
p＜0.05; * represents to compare with the normal control group,
p＜0.01;
# represents to compare with the radiation model group,
p＜0.05; ## represents to compare with the radiation model group,
p＜0.01.
3, to the influence of hemopoietic function
Hemopoietic system is to the radiation height sensitivity, and radiation is the pith of radiological study to the influence of blood and medulla hematopoietic system.Hematopoietic stem cell sharply reduces after the radiation, and the mature blood cell source is deficient in the peripheral blood, and leukocyte significantly reduces.
(1) peripheral blood cells counting
Each organize mice respectively at radiation before, 1,3,7,14,21 day tail point blood sampling after the radiation, counting hemocyte.The results are shown in Table 4-6, respectively organize leukocyte (WBC) counting there was no significant difference before the radiation, each group of normal control group WBC counting and all the other all has significant difference (p＜0.01) after the radiation, 1 day radioprotective Chinese medicine preparation height, middle dosage group WBC counting have significant difference (p＜0.05) with the radiation model group after the radiation, and 3 days and 14 days radioprotective Chinese medicine preparation high dose group and radiation model group have significant difference (p＜0.05) after the radiation; After the radiation 3 days and 7 days normal control group erythrocyte (RBC) with all the other each group significant difference (p＜0.05) is arranged all, but radioprotective Chinese medicine preparation group and radiation matched group there was no significant difference illustrate that the radioprotective Chinese medicine preparation is to rising
60Co gamma-radiation mice peripheral blood leucocyte has certain effect.
Table 4 radioprotective Chinese medicine preparation is right
60The influence of Co gamma-radiation mice peripheral blood leucocyte
* represent to compare with the normal control group,
p＜0.05; * represents to compare with the normal control group,
p＜0.01;
# represents to compare with the radiation model group,
p＜0.05; ## represents to compare with the radiation model group,
p＜0.01.
Table 5 radioprotective Chinese medicine preparation is right
60The influence of Co gamma-radiation mice peripheral red blood cells
* represent to compare with the normal control group,
p＜0.05; * represents to compare with the normal control group,
p＜0.01;
# represents to compare with the radiation model group,
p＜0.05.
Table 6 radioprotective Chinese medicine preparation is right
60The influence of Co gamma-radiation mice peripheral blood platelet (PLT)
* represent to compare with the normal control group,
p＜0.05; * represents to compare with the normal control group,
p＜0.01.
(2) bone marrow cell micronucleus rate
The cell micronucleus rate can reflect that the impaired situation of chromosome is the degree of radiation damage and the repair ability of body.
Get
60Behind the Co gamma-radiation 7 days respectively organize mice, investigate bone marrow cell micronucleus rate.The result is with table 7, and mice is subjected to
60Its bone marrow cell micronucleus rate is apparently higher than normal control group (p＜0.01) behind the Co gamma-radiation, the bone marrow cell micronucleus rate of radioprotective Chinese medicine preparation high dose group obviously reduces than the radiation matched group, difference has significance (p＜0.01), illustrates that the radioprotective Chinese medicine preparation has inhibition
60Co is gamma-ray to cause the chromosomal aberration effect.
Table 7 radioprotective Chinese medicine preparation is right
60The influence of Co gamma-radiation mouse Bone marrow cells micronucleus rate
* represents to compare with the normal control group,
p＜0.01; ## represents to compare with the radiation model group,
p＜0.01.
The toxicologic study of embodiment 3, radioprotective Chinese medicine preparation
Carry out the studies on acute toxicity of radioprotective Chinese medicine preparation according to " Chinese medicine, natural drug studies on acute toxicity technological guidance principle ".Adopt Kunming mouse, male and female half and half.Fasting is 12 hours before testing, and is subjected to examination group mice to irritate stomach according to the embodiment 1 prescription 3 capsule 's content solution that make, sooner or later respectively once with maximum dosage; Matched group is irritated stomach equivalent normal saline.Observe body weight, diet, outward appearance, behavior, secretions, drainage, poisoning and the death condition of respectively organizing mice, observed continuously 14 days.The result shows that the mice maximum dosage-feeding of radioprotective Chinese medicine preparation 2 gastric infusions on the 1st is 293.6g/Kg, 142 times of the oral dose on the 1st that is equivalent to be grown up, and mice does not have acute toxic symptoms and takes place, histoorgan does not have pathological changes, illustrates that the safety of radioprotective Chinese medicine preparation is good, and toxic and side effects is low.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and not depart from the spirit and scope of the present invention that appended claims limits.
Claims (6)
1. radioprotective Chinese medicine preparation, it is characterized in that, described preparation is the capsule that is made after mix for 2:1 by the extract powder of Chinese medicine composition and microcrystalline Cellulose, and described Chinese medicine composition is composed of the following components by weight: Radix Astragali 160-200 part, Fructus Psoraleae 110-130 part, Radix Angelicae Sinensis 80-100 part, Herba Epimedii 160-200 part, Radix Rubiae 135-165 part, Fructus Ligustri Lucidi 110-130 part, Radix Paeoniae Alba 110-130 part, Radix Rehmanniae Preparata 110-130 part, Rhizoma Chuanxiong 80-100 part, Rhizoma Dioscoreae 215-265 part, Radix Glycyrrhizae Preparata 35-45 part; The xeraphium of the alcoholic solution extract that described extract powder is described Chinese medicine composition.
2. radioprotective Chinese medicine preparation according to claim 1, it is characterized in that described Chinese medicine composition is composed of the following components by weight: Radix Astragali 170-190 part, Fructus Psoraleae 115-125 part, Radix Angelicae Sinensis 85-95 part, Herba Epimedii 170-190 part, Radix Rubiae 142-157 part, Fructus Ligustri Lucidi 115-125 part, Radix Paeoniae Alba 115-125 part, Radix Rehmanniae Preparata 115-125 part, Rhizoma Chuanxiong 85-95 part, Rhizoma Dioscoreae 230-250 part, Radix Glycyrrhizae Preparata 38-42 part.
3. radioprotective Chinese medicine preparation according to claim 2, it is characterized in that described Chinese medicine composition is composed of the following components by weight: 180 parts of the Radixs Astragali, 120 parts of Fructus Psoraleaes, 90 parts of Radix Angelicae Sinensis, 180 parts of Herba Epimedii, 150 parts of Radix Rubiae, 120 parts of Fructus Ligustri Lucidi, 120 parts of the Radix Paeoniae Albas, 120 parts in Radix Rehmanniae Preparata, 90 parts of Rhizoma Chuanxiongs, 240 parts of Rhizoma Dioscoreaes, 40 parts of Radix Glycyrrhizae Preparatas.
4. according to claim 1 or 2 or 3 described radioprotective Chinese medicine preparation, it is characterized in that the volume fraction of described alcoholic solution is 75%.
5. the preparation method of the described radioprotective Chinese medicine preparation of claim 1 is characterized in that, comprises following steps:
A. get Chinese medicine composition, be ground into fine powder, extract 2 ~ 3 times with alcoholic solution, extracting solution reclaims solvent to the thick paste shape, and drying under reduced pressure powdered again makes the extract powder of Chinese medicine composition;
B. with the extract powder of the Chinese medicine composition of step a gained and microcrystalline Cellulose by weight for 2:1 mixes, be wetting agent soft material processed with the alcoholic solution, granulation, drying, granulate, the capsulae vacuus of packing into namely gets the radioprotective Chinese medicine preparation.
6. the preparation method of radioprotective Chinese medicine preparation according to claim 5 is characterized in that, described step a is to be 75% alcoholic solution reflux, extract, 2 times with volume fraction, each 2 hours; Described step b is to be that 95% alcoholic solution is wetting agent with volume fraction.
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| CN103405373B (en) * | 2013-08-29 | 2014-05-28 | 山东福瑞达生物工程有限公司 | Natural emulsion as well as preparation method and application thereof |
| CN104001149A (en) * | 2014-05-27 | 2014-08-27 | 刘存兵 | Traditional Chinese medicine composition for treating radiation injuries and preparation method thereof |
| CN104940567A (en) * | 2015-07-22 | 2015-09-30 | 单裕清 | Chinese material medicine preparation for treating mild hemopoietic acute radiation sickness and preparation method thereof |
| CN105944031A (en) * | 2016-06-28 | 2016-09-21 | 牡丹江医学院红旗医院 | Anti-radiation traditional Chinese medicine and preparation method |
| CN105902970A (en) * | 2016-06-29 | 2016-08-31 | 李翠锦 | Chuanxiong rhizome-containing traditional Chinese medicine composition for preventing and treating radiation |
| CN105943597A (en) * | 2016-06-29 | 2016-09-21 | 李翠锦 | Traditional Chinese medicine composition capable of enhancing immunity and preventing and treating radiation diseases |
| CN105902607A (en) * | 2016-06-29 | 2016-08-31 | 李翠锦 | Fiveleaf gynostemma herb-containing traditional Chinese medicine composition |
| CN115779014B (en) * | 2022-12-12 | 2024-03-29 | 中国航天员科研训练中心 | Anti-radiation traditional Chinese medicine composition and preparation method thereof |
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