CN106039041B - Traditional Chinese medicine composition for preventing and treating nuclear radiation injury - Google Patents

Traditional Chinese medicine composition for preventing and treating nuclear radiation injury Download PDF

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CN106039041B
CN106039041B CN201610390811.6A CN201610390811A CN106039041B CN 106039041 B CN106039041 B CN 106039041B CN 201610390811 A CN201610390811 A CN 201610390811A CN 106039041 B CN106039041 B CN 106039041B
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田杰
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BEIJING QMLC STEM CELL TECHNOLOGY Co.,Ltd.
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating nuclear radiation damage caused by radiotherapy, which comprises the following components in part by weight: 5-20 parts of red peony root; 10-30 parts of cortex moutan; 10-30 parts of salvia miltiorrhiza; 10-30 parts of gastrodia elata; 5-20 parts of eucommia ulmoides; 15-25 parts of poria with hostwood; 15-40 parts of angelica; 10-20 parts of radix ophiopogonis; 10-25 parts of Chinese dates. The traditional Chinese medicine composition can be used for preventing and treating nuclear radiation damage, improving the function of a hematopoietic system, improving the immunity, improving the damage to the human body function caused by radiotherapy side effects, prolonging the life cycle and improving the life quality of radiotherapy patients.

Description

Traditional Chinese medicine composition for preventing and treating nuclear radiation injury
Technical Field
The invention relates to a traditional Chinese medicine composition for preventing and treating nuclear radiation injury.
Background
Radiation therapy is currently applied to many tumors. The radiation includes alpha, beta and gamma rays generated by radioactive isotopes, and x-rays, electron beams, proton beams and other particle beams generated by various x-ray therapeutic machines or accelerators. About 70% of cancer patients require radiation therapy in the course of treating cancer.
While killing cancer cells, radiotherapy also damages normal cells of the patient, so that the treatment effect is greatly reduced, and the condition of the patient is aggravated and even dies due to side effects caused by radiotherapy.
the research on the use of Chinese herbal medicines for preventing and treating the side effects of radiotherapy and chemotherapy is carried out. The Chinese patent application 2011100889515 discloses a Chinese medicinal preparation for preventing and treating radiation and a preparation method thereof, relates to a Chinese medicinal preparation for treating and preventing radiation injury and a preparation method thereof, and specifically comprises radix pseudostellariae, poria cocos, bighead atractylodes rhizome, liquorice, ligusticum wallichii, angelica sinensis, red paeony root, radix rehmanniae, barbed skullcap herb, honeysuckle, winter mulberry leaf, hairyvein agrimony, medlar and green tea which are prepared according to a certain proportion. Pharmacodynamic experiments carried out by an animal model adopting 60 Co-gamma rays to cause the reduction of the shaped blood cells and bone marrow nucleated cells of the white mouse show that the preparation has good effect on the blood cells and hematopoietic tissues damaged by nuclear radiation.
chinese patent application 2013100711070 discloses a medicine for protecting nuclear radiation damage, which is prepared from the following raw materials in parts by weight: american ginseng: 5-40 parts of Chinese angelica: 2-25 parts of adenophora tetraphylla: 3-35 parts, hairyvein agrimony: 5-40 parts of rhizoma paridis: 3-30 parts; the applicant proves that the medicine for protecting the nuclear radiation damage can effectively protect the damage of the hematopoietic system and the reproductive system caused by the nuclear radiation, improve the immunity and has obvious prevention and treatment effects by the influence on a blood deficiency model mouse caused by the 60Co ray radiation, and the medicine is a potential anti-radiation protection medicine.
Disclosure of Invention
The purpose of the application is to provide a traditional Chinese medicine composition for preventing and treating nuclear radiation damage caused by radiotherapy, which not only aims at improving the hematopoietic system and the reproductive system, but also mobilizes the functions of the whole body, improves the resistance of the human body to the damage caused by the radiotherapy and improves the life quality of patients after the radiotherapy.
The traditional Chinese medicine composition for preventing and treating nuclear radiation damage caused by radiotherapy comprises the following components:
5-20 parts of red peony root; 10-30 parts of cortex moutan; 10-30 parts of salvia miltiorrhiza; 10-30 parts of gastrodia elata; 5-20 parts of eucommia ulmoides and 15-25 parts of poria with hostwood; 15-40 parts of angelica; 10-20 parts of radix ophiopogonis; 10-25 parts of Chinese dates.
preferably, the composition comprises:
12-18 parts of red peony root; 15-30 parts of cortex moutan; 20-30 parts of salvia miltiorrhiza; 10-20 parts of gastrodia elata; 5-15 parts of eucommia ulmoides; 15-20 parts of poria with hostwood; 20-30 parts of angelica; 12-18 parts of radix ophiopogonis; 15-25 parts of Chinese dates.
More preferably, the composition comprises:
14-16 parts of red peony root; 18-22 parts of cortex moutan; 20-25 parts of salvia miltiorrhiza; 10-15 parts of gastrodia elata; 8-12 parts of eucommia ulmoides; 15-20 parts of poria with hostwood; 25-30 parts of angelica; 12-15 parts of radix ophiopogonis; 15-25 parts of Chinese dates.
Because a patient suffers from tumors and is vigorous in tumor growth and mostly deficient in qi and blood, radiation therapy is adopted to cause blood heat stasis, disturbance of heart spirit, damage to spleen and stomach and the like, therefore, aiming at the syndrome differentiation of patients who are subjected to radiation therapy, the inventor adopts red paeony root, cortex moutan, salvia miltiorrhiza to cool blood and remove blood stasis, gastrodia elata and eucommia to suppress liver yang, poria with hostwood to calm heart and tranquilize mind, angelica sinensis to enrich blood, and Chinese date and radix ophiopogonis to invigorate spleen and nourish stomach. The above medicines can be used together to improve hemogram of patients suffering from tumor radiotherapy, enhance immunity of patients suffering from radiotherapy, and enhance SOD activity, thereby prolonging life cycle and improving quality of life of patients suffering from radiotherapy.
The traditional Chinese medicine composition can be prepared into conventional dosage forms such as granules, oral liquid, concentrated capsules, pills and the like according to a conventional method.
For example, the raw materials can be added with clear water and decocted for two times, the first time is 1.5-2.5 hours, the second time is 0.5-1.5 hours, clear water with the weight 8-20 times of the dry weight of the raw materials is added for each time, the two decocted liquids are combined and orally taken, twice a day and 10-15ml each time. Or concentrating the decoction of the two times of decoction and making into concentrated capsule, wherein the weight of each capsule is 0.5-0.8 g.
Through clinical trial, the traditional Chinese medicine composition can be used for preventing and treating nuclear radiation damage, improving the function of a hematopoietic system, improving the immunity, improving the damage to the human body function caused by radiotherapy side effects, improving the prognosis of patients, and particularly prolonging the life cycle and improving the life quality of radiotherapy patients compared with a control group.
Detailed Description
the present invention will be specifically described below with reference to examples.
Example 1
16g of red paeony root; 20g of cortex moutan; 25g of salvia miltiorrhiza; 15g of gastrodia elata; 8g of eucommia ulmoides; poria 20 g; 25g of Chinese angelica; 15g of radix ophiopogonis; 20g of Chinese dates.
Putting the traditional Chinese medicine raw materials into clear water with the weight being 12 times of the total weight of the traditional Chinese medicine raw materials, decocting for 2 hours, and taking filtrate; then adding 8 times of clear water for decocting for 1 hour, taking the filtrate, combining the two filtrates, heating and concentrating to obtain paste, and encapsulating, wherein each capsule weighs 0.5 g.
Example 2
20g of red paeony root; 15g of cortex moutan; 25g of salvia miltiorrhiza; 25g of gastrodia elata; 12g of eucommia ulmoides; poria 20 g; 35g of Chinese angelica; 15g of radix ophiopogonis; 20g of Chinese dates.
Putting the traditional Chinese medicine raw materials into clear water with the weight being 12 times of the total weight of the traditional Chinese medicine raw materials, decocting for 2 hours, and taking filtrate; then adding 8 times of clear water, decocting for 1 hr, collecting filtrate, mixing the filtrates, and bottling to obtain oral liquid.
Example 3
16g of red paeony root; 20g of cortex moutan; 25g of salvia miltiorrhiza; 15g of gastrodia elata; 8g of eucommia ulmoides; poria 20 g; 25g of Chinese angelica; 15g of radix ophiopogonis; 20g of Chinese dates.
putting the traditional Chinese medicine raw materials into clear water with the weight being 12 times of the total weight of the traditional Chinese medicine raw materials, decocting for 2 hours, and taking filtrate; then adding 8 times of clear water, decocting for 1 hr, collecting filtrate, mixing the two filtrates, heating and concentrating to obtain paste, drying, pulverizing, adding excipient to make into granule, and packaging with 5-10g per bag.
the experimental process comprises the following steps:
Experiment one:
60 Kunming white mice are taken, and the second-level clean animals with the body weight of 20-25g and half of male and female are selected. The groups were randomly divided into a blank control group (gavage saline, no irradiation), a positive control group (gavage saline, irradiation), the example 1 low dose group (20mg/kg, irradiation), the example 1 medium dose group (40mg/kg, irradiation), the example 1 high dose group (80mg/kg, irradiation), and 12 individuals per group. The blank control group and the positive control group are irrigated with 0.5ml of physiological saline every day, and the low, medium and high drug groups are irrigated with 0.5ml of physiological saline after the drugs are weighed according to the corresponding doses. After the groups are continuously gavage for 14 days, the positive control group and the low, medium and high dose groups are irradiated by 60 Co-gamma with the skin source distance of 100mm and the GY/min, and the total dose of the irradiation is 3.5 GY. After all animals continue to be intragastrically filled according to the original prescription for 14 days, the weight is weighed, blood is taken from eye sockets, then cervical vertebrae is removed, and the animals are killed, and viscera (spleen and thymus) are taken.
1. White blood cell count:
TABLE-Effect of Chinese medicinal composition for preventing and treating nuclear radiation injury on peripheral blood leukocyte of mouse
Group of 9Number of leukocytes (. times.109/L)
Blank control group 3.52±0.68
Positive control group 1.37±0.22
Low dose group 1.95±1.40*
Middle dose group 2.27±0.64*
High dose group 2.45±0.75*
Note: p < 0.01 in comparison with positive control group
The experiment result shows that the number of white blood cells is reduced due to severe damage of mouse immune cells irradiated by total dose of 3.5GY (positive control group), and the low, medium and high dose groups in example 1 of the experiment have significant difference (P is less than 0.01) compared with the positive control group, which indicates that the traditional Chinese medicine composition has a protective effect on nuclear radiation damage of the mouse immune cells.
Spleen and thymus indices:
Influence of the traditional Chinese medicine composition for preventing and treating nuclear radiation injury on spleen and thymus indexes of mice
Group of spleen index (mg/g X10) Thymus index (mg/g X10)
Blank control group 9.02±1.74 3.28±0.83
Positive control group 7.26±1.32 1.35±0.27
Low dose group 8.03±1.39* 1.94±0.48*
Middle dose group 8.44±1.51* 2.27±0.51*
High dose group 8.51±1.63* 2.39±0.46*
Note: p < 0.05 compared to positive control group
the experiment result shows that the immune system of a mouse irradiated by 3.5GY of the total dose is seriously injured (a positive control group), so that the weight of spleen and thymus is reduced, and the low, medium and high dose groups in the experiment 1 have significant differences (P is less than 0.05) compared with the positive control group, which indicates that the traditional Chinese medicine composition has a protective effect on the nuclear radiation injury of the immune system of the mouse.
2. SOD activity determination:
Influence of traditional Chinese medicine composition for preventing and treating nuclear radiation damage of epidermoid saururus on mouse SOD (superoxide dismutase)
note: p < 0.01 in comparison with positive control group
SOD is the main substance for preventing lipid peroxidation by clear free radicals, and has important significance in the aspects of nuclear radiation resistance and aging resistance. The experimental result shows that the low, medium and high dose groups in the example 1 have significant difference (P is less than 0.01) compared with the positive control group, which indicates that the traditional Chinese medicine composition has the effects of improving the removal of free radicals and accelerating the repair of nuclear radiation damage to mice.
Experiment two:
80 Kunming white mice are taken, and the second-level clean animals with the body weight of 20-25g and half of male and female are selected. Control group (gavage saline, irradiation), example 1 low dose group (20mg/kg, irradiation), example 1 medium dose group (40mg/kg, irradiation), example 1 high dose group (80mg/kg, irradiation), 20 subjects per group. The control group is administered with 0.5ml physiological saline every day, and the low, medium and high drug groups are administered with 0.5ml physiological saline after weighing the drugs according to the corresponding dosage. After the groups are continuously gavage for 14 days, the positive control group and the low, medium and high dose groups are irradiated by 60 Co-gamma with the skin source distance of 100mm and the GY/min, and the total dose of irradiation is 8.2 GY. Mice were recorded for 30 days survival.
TABLE 4 Effect of Chinese medicinal composition for preventing and treating nuclear radiation injury on 30-day survival rate of mice
Note: p < 0.05, P < 0.01, compared to positive control
mice irradiated with a total dose of 8.2GY were severely injured (positive control: LD90) and had a 10% survival rate after 30 days. The experimental results show that the low, medium and high dose groups in example 1 of the experiment have significant differences compared with the control group, which shows that the traditional Chinese medicine composition can improve the survival rate of mice suffering from lethal nuclear radiation injury.

Claims (4)

1. A traditional Chinese medicine composition for preventing and treating nuclear radiation damage caused by radiotherapy comprises the following raw materials:
5-20 parts of red peony root; 10-30 parts of cortex moutan; 10-30 parts of salvia miltiorrhiza; 10-30 parts of gastrodia elata; 5-20 parts of eucommia ulmoides; 15-25 parts of poria with hostwood; 15-40 parts of angelica; 10-20 parts of radix ophiopogonis; 10-25 parts of Chinese dates.
2. The traditional Chinese medicine composition according to claim 1, which consists of the following raw materials:
12-18 parts of red peony root; 15-30 parts of cortex moutan; 20-30 parts of salvia miltiorrhiza; 10-20 parts of gastrodia elata; 5-15 parts of eucommia ulmoides; 15-20 parts of poria with hostwood; 20-30 parts of angelica; 12-18 parts of radix ophiopogonis; 15-25 parts of Chinese dates.
3. A method of preparing the traditional Chinese medicine composition of claim 1 or 2, the method comprising:
Decocting the traditional Chinese medicine raw materials twice with clear water, adding clear water with the weight 8-20 times of the total dry weight of the raw materials each time, and combining the two decoctions to prepare the oral liquid.
4. A method of preparing the traditional Chinese medicine composition of claim 1 or 2, the method comprising:
Decocting the traditional Chinese medicine raw materials twice with clear water, adding clear water 8-20 times of the total dry weight of the raw materials each time, mixing the decoctions, concentrating the decoction, and making into concentrated capsules, wherein the weight of each capsule is 0.5-0.8 g.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102139021A (en) * 2011-04-11 2011-08-03 扬州大学 Chinese medicinal preparation for preventing and treating radiation and preparation method thereof
CN102166301A (en) * 2011-04-21 2011-08-31 扬州大学 Chinese herbal external cream for preventing and treating radiation and preparation method thereof
CN103169843A (en) * 2013-03-06 2013-06-26 唐俊琪 Compound medicine having radiation resisting and protecting effects
CN103768284A (en) * 2014-02-14 2014-05-07 李伟 Medicine for radiodermatitis and preparation method thereof
CN103816403A (en) * 2014-03-25 2014-05-28 梁黎明 Chinese medicinal composition for treating syndrome of deficiency of liver blood

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102139021A (en) * 2011-04-11 2011-08-03 扬州大学 Chinese medicinal preparation for preventing and treating radiation and preparation method thereof
CN102166301A (en) * 2011-04-21 2011-08-31 扬州大学 Chinese herbal external cream for preventing and treating radiation and preparation method thereof
CN103169843A (en) * 2013-03-06 2013-06-26 唐俊琪 Compound medicine having radiation resisting and protecting effects
CN103768284A (en) * 2014-02-14 2014-05-07 李伟 Medicine for radiodermatitis and preparation method thereof
CN103816403A (en) * 2014-03-25 2014-05-28 梁黎明 Chinese medicinal composition for treating syndrome of deficiency of liver blood

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
中药对大鼠辐射损伤防护作用的实验研究;郭军等;《中华放射医学与防护杂志》;20060630;第26卷(第3期);第235-238页 *
中药抗辐射作用研究进展;段雅彬等;《药学研究》;20150215;第34卷(第2期);第95-99页 *
抗辐射中药及天然产物的研究进展;伦博书等;《国际药学研究杂志》;20150831;第42卷(第4期);第453-462页 *

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