CN101543608A - Medicine composition for adjuvant treatment of breast cancer and preparation method thereof - Google Patents
Medicine composition for adjuvant treatment of breast cancer and preparation method thereof Download PDFInfo
- Publication number
- CN101543608A CN101543608A CN200810102949A CN200810102949A CN101543608A CN 101543608 A CN101543608 A CN 101543608A CN 200810102949 A CN200810102949 A CN 200810102949A CN 200810102949 A CN200810102949 A CN 200810102949A CN 101543608 A CN101543608 A CN 101543608A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- breast cancer
- adjuvant treatment
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composition for the adjuvant treatment of breast cancer and a preparation method thereof. The medicine composition comprises functional ingredients and pharmaceutically acceptable carriers, wherein the effective ingredients are prepared by extracting radix astragali, codonopsis pilosula, turmeric root tuber, Chinese angelica, red paeony root, pangolin scales, cowherb seed, bighead atractylodes rhizome, white paeony root, paris polyphylla, red-rooted salvia root, coix seed, bupleurum, mint, liquorice, peony tree root bark, and the like. The medicine composition has the efficacies of strengthening body resistance and eliminating evil, soothing stagnation and promoting blood circulation and resolving hard lump, and is used for the adjuvant treatment of the breast cancer and the reduction of the adverse reactions caused by chemotherapy and radiotherapy.
Description
Technical field:
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for adjuvant treatment of breast cancer and preparation method thereof.
Technical background
Breast carcinoma is the malignant tumor that is taken place by the breast duct epithelium, is women's common cancer.The whole world has more than 100 ten thousand women to suffer from breast carcinoma every year approximately.The male also can suffer from breast cancer, but the chance that the male suffers from breast cancer is lacked 100 times than the women.The predilection site of breast carcinoma occupies the majority on outside the breast.Breast carcinoma of early stage can not have any subjective symptoms; pathological changes mammary gland tumor can occur late period; the top sees that quality is tough firmly more beyond the lump position, and the border is very not clear; no peplos sense; the mobility that pushes away is little, most no obvious pain, and retraction, off normal appear in nipple; from nipple 2-3 centimeters nipple overflow yellow fluid or blood and slime, and the cancerous eczema sample changes.
In many western countries, the sickness rate of breast carcinoma accounts for the first place of women's cancerous protuberance.In China, breast carcinoma accounts for the first two position of women's malignant tumor.According to interrelated data, its sickness rate is 23,/10 ten thousand population in the women, then only is 0.49/10 ten thousand populations the male.Man's breast carcinoma accounts for about 1% of whole breast carcinoma greatly.Breast carcinoma occurs in 40～60 years old mostly, or the women before and after menopause, and is especially the highest with 45～49 years old and 60～64 years old intercurrent disease rate.
Surgical intervention: the main treatment means of breast carcinoma is an excision.In early days, the breast carcinoma patient of mid-term, middle and advanced stage, as long as condition can tolerate operation, all should first-selected operative treatment.The purpose of operative treatment is to make primary tumo(u)r and regional lymph nodes can obtain farthest local control, reduces local recurrence, improves patient's survival rate.Must decide modus operandi according to position, patient age, requirement and the doctor's of tumor experience, the result of pathologic finding, not have a kind of generally acknowledged best modus operandi at present.
Chemotherapy: comprise the chemotherapy before performing the operation, after the neutralization.Especially the most commonly used with the adjuvant chemotherapy of postoperative, its objective is the residual minimum cancer focus in elimination operation back, there is not the life cycle of recurrence thereby prolong, reduce mortality rate, improve survival rate.The basic principle of postoperative chemotherapy is early stage, capacity, effective Combination chemotherapy.The common toxicity of chemotherapeutics has the gastrointestinal tract reflection to answer bone marrow depression.Intensive chemotherapy may cause the particularly inhibition of T cell function of immunologic function, thereby causes some to infect, such as the susceptibility of herpes zoster increases.
Radiotherapy: the past radiotherapy is the palliative treatment as supplement therapy or late period, recurrent cases after the operation.Carried out the minor operation scope from the eighties and added the research that breast carcinoma of early stage is treated in radiation, at present in American-European countries's widespread usage, become one of main topical therapeutic mode of early-stage breast cancer, but carry out less at home.
The traditional Chinese medical science, Chinese medicine are the traditional therapies of China, can improve patient's whole body situation, the reaction of alleviating, radiotherapy, Chang Zuowei operation, radiocurable auxiliary treatment means and as the main Therapeutic Method of advanced tumor, advantage is that side effect is little, and the patient is easy to accept.
The traditional Chinese medical science thinks that the basic pathogenesis of breast carcinoma is that yang deficiency causes function low, a little less than the deficiency of vital energy blood, dashes wantonly two arteries and veins inanitions, and QI-blood circulation is not normal, so that Chong and Ren channel disorder, qi depression to blood stasis, and then poly-for a long time expectorant is made poison, is condensed in the Ruzhong and forms cancer.Seeing the development of its course of disease, is because of the empty reality that causes, and because of real more empty, causes simulataneous insufficiency and excessive, deficiency in origin and mark reality.Therefore, in determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, should distinguish the primary and secondary of deficiency and excess, distinguish excess and weakness of pathogen and vital QI, conscientiously be based on strengthening vital QI to eliminate pathogenic factors and execute after the balance, setting upright, eliminating evil be assist greatly then, strive to set upright eliminating evilly, set upright with eliminating evil.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen that is used for adjuvant treatment of breast cancer.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
150-450 parts of 150-450 parts of Radix Curcumaes of 150-450 parts of Radix Codonopsis of the Radix Astragali
100-300 parts of 150-450 parts of roasted SQUAMA MANITIS into puffy with sand of 150-450 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
100-300 parts of 100-300 parts of Radix Paeoniae Albas of 100-300 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
100-300 parts of 100-300 parts of Semen Coiciss of 100-300 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
100-300 parts in 100-300 parts of Radix Glycyrrhizaes of 100-300 parts of Herba Menthaes of Radix Bupleuri
100-300 parts of Cortex Moutans
The active component that preferred following raw materials according is made, curative effect is better:
300 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 300 parts of roasted SQUAMA MANITIS into puffy with sand of 300 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 100 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
150 parts of 150 parts of Semen Coiciss of 150 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
150 parts in 100 portions of Radix Glycyrrhizaes of 150 portions of Herba Menthaes of Radix Bupleuri
150 parts of Cortex Moutans
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Astragali, Radix Codonopsis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Radix Angelicae Sinensis, Radix Paeoniae Rubra, roasted SQUAMA MANITIS into puffy with sand, Semen Vaccariae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Semen Coicis, Radix Bupleuri, Herba Menthae, Radix Glycyrrhizae, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has strengthening vital QI to eliminate pathogenic factors, and resolving depression is invigorated blood circulation, the effect of hard masses softening and resolving, is used for the auxiliary treatment of breast carcinoma and alleviating, the caused untoward reaction of radiotherapy.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
300 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 300 parts of roasted SQUAMA MANITIS into puffy with sand of 300 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 100 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
150 parts of 150 parts of Semen Coiciss of 150 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
150 parts in 100 portions of Radix Glycyrrhizaes of 150 portions of Herba Menthaes of Radix Bupleuri
150 parts of Cortex Moutans
2. preparation technology
(1) Radix Astragali, Radix Codonopsis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Radix Angelicae Sinensis, Radix Paeoniae Rubra, roasted SQUAMA MANITIS into puffy with sand, Semen Vaccariae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Semen Coicis, Radix Bupleuri, Herba Menthae, Radix Glycyrrhizae, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
300 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 300 parts of roasted SQUAMA MANITIS into puffy with sand of 300 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 100 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
150 parts of 150 parts of Semen Coiciss of 150 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
150 parts in 100 portions of Radix Glycyrrhizaes of 150 portions of Herba Menthaes of Radix Bupleuri
150 parts of Cortex Moutans
2. preparation technology
(1) Radix Astragali, Radix Codonopsis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Radix Angelicae Sinensis, Radix Paeoniae Rubra, roasted SQUAMA MANITIS into puffy with sand, Semen Vaccariae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Semen Coicis, Radix Bupleuri, Herba Menthae, Radix Glycyrrhizae, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
300 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 300 parts of roasted SQUAMA MANITIS into puffy with sand of 300 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 100 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
150 parts of 150 parts of Semen Coiciss of 150 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
150 parts in 100 portions of Radix Glycyrrhizaes of 150 portions of Herba Menthaes of Radix Bupleuri
150 parts of Cortex Moutans
2. preparation technology
(1) Radix Astragali, Radix Codonopsis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Radix Angelicae Sinensis, Radix Paeoniae Rubra, roasted SQUAMA MANITIS into puffy with sand, Semen Vaccariae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Semen Coicis, Radix Bupleuri, Herba Menthae, Radix Glycyrrhizae, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen that is used for adjuvant treatment of breast cancer is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according.
150-450 parts of 150-450 parts of Radix Curcumaes of 150-450 parts of Radix Codonopsis of the Radix Astragali
100-300 parts of 150-450 parts of roasted SQUAMA MANITIS into puffy with sand of 150-450 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
100-300 parts of 100-300 parts of Radix Paeoniae Albas of 100-300 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
100-300 parts of 100-300 parts of Semen Coiciss of 100-300 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
100-300 parts in 100-300 parts of Radix Glycyrrhizaes of 100-300 parts of Herba Menthaes of Radix Bupleuri
100-300 parts of Cortex Moutans.
2, a kind of drug regimen that is used for adjuvant treatment of breast cancer according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient.
300 parts of 300 portions of Radix Curcumaes of 300 parts of Radix Codonopsis of the Radix Astragali
100 parts of 300 parts of roasted SQUAMA MANITIS into puffy with sand of 300 parts of Radix Paeoniae Rubra of Radix Angelicae Sinensis
150 parts of 150 portions of Radix Paeoniae Albas of 100 parts of Rhizoma Atractylodis Macrocephalaes of Semen Vaccariae
150 parts of 150 parts of Semen Coiciss of 150 parts of Radix Salviae Miltiorrhizaes of Rhizoma Paridis
150 parts in 100 portions of Radix Glycyrrhizaes of 150 portions of Herba Menthaes of Radix Bupleuri
150 parts of Cortex Moutans.
3, according to the described a kind of drug regimen that is used for adjuvant treatment of breast cancer of claim 1-2, it is characterized in that adopting following method to make:
(1) Radix Astragali, Radix Codonopsis add 80% alcohol dipping three times, flood 48 hours for the first time, and second and third time flooded respectively 24 hours, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Curcumaes, Radix Angelicae Sinensis, Radix Paeoniae Rubra, roasted SQUAMA MANITIS into puffy with sand, Semen Vaccariae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Paridis, Radix Salviae Miltiorrhizae, Semen Coicis, Radix Bupleuri, Herba Menthae, Radix Glycyrrhizae, Cortex Moutan add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen that is used for adjuvant treatment of breast cancer among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for adjuvant treatment of breast cancer of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810102949A CN101543608A (en) | 2008-03-28 | 2008-03-28 | Medicine composition for adjuvant treatment of breast cancer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810102949A CN101543608A (en) | 2008-03-28 | 2008-03-28 | Medicine composition for adjuvant treatment of breast cancer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101543608A true CN101543608A (en) | 2009-09-30 |
Family
ID=41191150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810102949A Pending CN101543608A (en) | 2008-03-28 | 2008-03-28 | Medicine composition for adjuvant treatment of breast cancer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101543608A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579766A (en) * | 2012-03-29 | 2012-07-18 | 翟西菊 | Anti-tumor medicine |
| CN105920084A (en) * | 2016-06-07 | 2016-09-07 | 宋佳玉 | Traditional Chinese medicine composition for treating breast cancer and preparation method of traditional Chinese medicine composition |
-
2008
- 2008-03-28 CN CN200810102949A patent/CN101543608A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579766A (en) * | 2012-03-29 | 2012-07-18 | 翟西菊 | Anti-tumor medicine |
| CN105920084A (en) * | 2016-06-07 | 2016-09-07 | 宋佳玉 | Traditional Chinese medicine composition for treating breast cancer and preparation method of traditional Chinese medicine composition |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102716417B (en) | Traditional Chinese medicine preparation for treating gynaecopathia and preparation method of preparation | |
| CN101837065A (en) | Medicine with anti-hepatitis, anti-tumour and organism immunity improving functions and preparation method thereof | |
| CN101264205A (en) | Chinese medicinal composition for treating gout and preparation thereof | |
| CN102552638B (en) | Anticancer drug, as well as preparation method and application of same | |
| CN101264215A (en) | Medicinal composition for treating acute and chronic urarthritis and preparation thereof | |
| CN101744956A (en) | Medicinal composition for treating pelvic inflammation and preparation method thereof | |
| CN102247479A (en) | Antitumor strong medicine and preparation method thereof | |
| CN101264297A (en) | Medicaments assembly for treating menorrhalgia and preparation thereof | |
| CN101543608A (en) | Medicine composition for adjuvant treatment of breast cancer and preparation method thereof | |
| CN101264314A (en) | Medicaments assembly for clearing heat and detoxication, activating blood circulation and removing stasis, and diminishing inflammation and reducing pain | |
| CN115227795A (en) | Compound medicine for treating HPV persistent infection and preparation method and application thereof | |
| CN106214905A (en) | A kind of Chinese medicine composition treating mastitis and preparation method thereof | |
| CN105902951A (en) | Traditional Chinese medicinal compound for treating osteosarcomas on basis of chemotherapeutic drugs | |
| CN101543609A (en) | Traditional Chinese medicine for treating breast cancer and preparation method thereof | |
| CN1125111A (en) | Chinese proprietary medicine for curing stomach trouble, duodenal ulcer and chronic gastritis | |
| CN103285172B (en) | Chinese medicament composition for treating myoma of uterus and endometrial cancer and application thereof | |
| CN101543597A (en) | Medicine composition for nourishing spleen and kidney and building up healthful vital energy and preparation method thereof | |
| CN108144038B (en) | Traditional Chinese medicine composition for removing chloasma and application thereof | |
| CN101543566A (en) | Medicine composition for curing breast cancer and preparation method thereof | |
| CN105250588A (en) | Chinese herbal preparation for treating kidney failure and preparation method of Chinese herbal preparation | |
| CN101485823B (en) | Medicament for treating lung cancer and preparation method thereof | |
| CN104069175A (en) | Extract used for preparing ligusticum wallichii tea modulator | |
| CN103768327A (en) | Pure component traditional Chinese medicinal formulation for treating functional dyspepsia and preparation method of formulation | |
| CN103893621A (en) | Traditional Chinese medicament for treating senile vaginitis | |
| CN103736008B (en) | Treatment breast carcinoma pharmaceutical composition being concurrently good for side Benign Nodule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090930 |