CN105902970A - Chuanxiong rhizome-containing traditional Chinese medicine composition for preventing and treating radiation - Google Patents
Chuanxiong rhizome-containing traditional Chinese medicine composition for preventing and treating radiation Download PDFInfo
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- CN105902970A CN105902970A CN201610487405.1A CN201610487405A CN105902970A CN 105902970 A CN105902970 A CN 105902970A CN 201610487405 A CN201610487405 A CN 201610487405A CN 105902970 A CN105902970 A CN 105902970A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a chuanxiong rhizome-containing traditional Chinese medicine composition which can effectively solve the problem of low immunity caused by long-term radiation so as to reduce radiation hazards. The traditional Chinese medicine composition provided by the invention is prepared from the following components as raw materials: 25-35 parts of chuanxiong rhizome, 10-20 parts of angelica, 10-15 parts of astragalus root, 8-12 parts of rhizoma zedoariae, 5-10 parts of fructus psoraleae and 1-5 parts of ginkgo leaves. A preparation method of the traditional Chinese medicine composition comprises the following steps: chipping and mixing the medicinal raw materials; decocting the mixture with 70-85% ethanol; filtering the decoction liquid; and carrying out vacuum concentration to obtain viscous paste, namely the traditional Chinese medicine composition.
Description
Technical field
The present invention relates to compositions, a kind of Chinese medicine composition preventing and treating radiation.
Background technology
Along with development and the extensive application of radiotherapy clinically of nuclear technology, particularly at medical domain, radiodiagnosis
Non-with treatment use extensively clinically, tumor patient being carried out radiotherapy and has become as the conventional means of oncotherapy, these all increase
Add the probability of medical personnel and radiation contacts.Radiation damage how is prevented to be increasingly subject to the attention of people.People start to amass
Pole is explored and is effectively radiated protective agents.
Long-term raying is irradiated, and human body can be made to produce discomfort, serious caused human organ and the damage of system, cause
The generation of various diseases, such as: leukemia, aplastic anemia, various tumor, retinopathy, reproductive system disease, senilism
Deng；Tradition Anti-Radiation Countermeasures mainly installs radiation prevention film additional on electrical equipment, or wears anti-radiation clothes etc..Due to more known tools
The chemicals toxicity having radiation resistance is relatively big, and the radioprotective Chinese medicine that therefore research toxic and side effects is little seems the most necessary.Specially
Profit CN 201410022608.4 discloses a kind of compositions with Radix Pseudostellariae, Fructus Psoraleae, Fructus Lycii, Herba Dendrobii etc. as component to be had
Good radiation resistance, patent CN201510455861.3 discloses a kind of alimentation composition reducing radiation hazradial bundle, has
Certain radiation resistance.
Summary of the invention
For above-mentioned situation, the present invention provides a kind of Chinese medicine composition preventing and treating radiation, by the collaborative work of different Chinese medicines
With, improve immunity, for alleviating or reduce the long-term harm accepting radiation.
The present invention adopts the following technical scheme that, this Chinese medicine composition, makes with following component for raw material: Rhizoma Chuanxiong, Radix Angelicae Sinensis, Huang
Stilbene, Rhizoma Curcumae, Fructus Psoraleae, Folium Ginkgo, by above-mentioned medicinal raw material chopping, mix, decoct with ethanol water, decoction liquor
Filter, concentrating under reduced pressure, obtain the mastic of thickness, obtain described Chinese medicine composition.
Further, preferably, the Chinese medicine composition that the present invention provides, make with following component for raw material: river
Rhizome of chuanxiong 25-35 part, Radix Angelicae Sinensis 10-20 part, Radix Astragali 10-15 part, Rhizoma Curcumae 8-12 part, Fructus Psoraleae 5-10 part, Folium Ginkgo 1-5 part.By above-mentioned
Medicinal raw material chopping, mix, decoct with the ethanol of 70-85%, decoction liquor filters, and concentrating under reduced pressure obtains the cream of thickness
Body, obtains described Chinese medicine composition.
Further preferably with Rhizoma Chuanxiong 25-30 part, Radix Angelicae Sinensis 15-18 part, Radix Astragali 10-15 part, Rhizoma Curcumae 10-12 part, Fructus Psoraleae 5-8
Part, Folium Ginkgo 3-5 part are as raw material；
More preferably using Rhizoma Chuanxiong 27 parts, Radix Angelicae Sinensis 16 parts, the Radix Astragali 12 parts, Rhizoma Curcumae 10 parts, Fructus Psoraleae 5 parts, Folium Ginkgo 3 parts as raw material.
Further, ethanol water volumetric usage is 6-10 times of raw medicinal material weight, preferred alcohol aqueous solution volume
Consumption is 8 times of raw medicinal material weight.
Detailed description of the invention
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
Rhizoma Chuanxiong 27 parts, Radix Angelicae Sinensis 16 parts, the Radix Astragali 12 parts, Rhizoma Curcumae 10 parts, Fructus Psoraleae 5 parts, Folium Ginkgo 3 parts；By above-mentioned raw medicinal material
Chopping, mixes, and the ethanol with 80% decocts, decoction liquor filtration, concentrating under reduced pressure obtains the mastic of thickness, and wherein 80%
Ethanol volumetric usage is 8 times of medicinal raw material weight.
Embodiment 2
Rhizoma Chuanxiong 25 parts, Radix Angelicae Sinensis 20 parts, the Radix Astragali 10 parts, Rhizoma Curcumae 12 parts, Fructus Psoraleae 10 parts, Folium Ginkgo 5 parts；By above-mentioned raw medicinal material
Chopping, mixes, and the ethanol with 85% decocts, decoction liquor filtration, concentrating under reduced pressure obtains the mastic of thickness, and wherein 85%
Ethanol volumetric usage is 6 times of medicinal raw material weight.
Embodiment 3
Rhizoma Chuanxiong 35 parts, Radix Angelicae Sinensis 10 parts, the Radix Astragali 15 parts, Rhizoma Curcumae 8 parts, Fructus Psoraleae 8 parts, Folium Ginkgo 1 part.Above-mentioned medicinal raw material is cut
Broken, mix, the ethanol with 70% decocts, and decoction liquor filters, and concentrating under reduced pressure obtains the mastic of thickness, the wherein second of 70%
Alcohol volumetric usage is 8 times of medicinal raw material weight.
Embodiment 4
Rhizoma Chuanxiong 31 parts, Radix Angelicae Sinensis 17 parts, the Radix Astragali 12 parts, Rhizoma Curcumae 10 parts, Fructus Psoraleae 7 parts, Folium Ginkgo 3 parts.By above-mentioned medicinal raw material
Chopping, mixes, and the ethanol with 75% decocts, and decoction liquor filters, and concentrating under reduced pressure obtains the mastic of thickness, obtains described
Chinese medicine composition.Wherein ethanol volumetric usage is medicinal raw material weight 10 times of 75%.
1, Antiradiation injury experiment:
With mice as object of study, investigate the Chinese medicine composition of the embodiment of the present invention 1 to 30 days survival rates of raying mice
Affecting, the human body of the Chinese medicine composition of the present invention recommends consumption to be 6g/60kg.BW every day, and following basic, normal, high dosage group is suitable
In 1 times, 5 times, 10 times of human body recommended dose, and test as follows:
(1) selecting SD mice, female 75, weight range is 20-22g.Raise one week in the case of feeding environment is identical；
(2) being randomly divided into 5 groups, often group 15, is divided into normal group, model control group, low dose group, middle dosage group, high dose group；
Normal group refuses any process, and model group gives distilled water, and basic, normal, high dosage component does not give the embodiment 1 of corresponding dosage
Chinese medicine composition, uses the mode of gavage (ig), every day 1 time, continuous gavage 30d；
5h after (3) the 30th days gavages, in addition to normal group, remaining 4 groups all carry out whole body disposable 60Co gamma-rays irradiate, irradiate away from
From for 1.0m, exposure dose is 8.5Gy；After irradiation, observed and recorded respectively organizes the survival state of mice, body weight change, calculates each group little
The mean survival time of Mus, 30d survival rate etc..
The Chinese medicine composition of the present invention is as shown in table 1 to the result (x ± s) of 30 days survival rates of raying mice.
Table 1
As it can be seen from table 1 when give the Chinese medicine composition of the present invention with low middle high dose, it is the poorest that it has with matched group
Different, it is seen then that the Chinese medicine composition of the present invention can significantly improve the survival rate by 8.5Gy roentgenization mice 30d, extend by spoke
Penetrate the life span of mice.Therefore, the Chinese medicine composition of the present invention has the effect of pre-radioprotective.
2, the impact on spleen
Spleen is maximum lymphatic organ, is also one of important peripheral immune organ, containing substantial amounts of T cell, NKT
Cell and Tumor-infiltrating lymphocytes etc..Spleen is also the place that haematogenous antigen produces immunne response, can synthesize
And secrete such as the bioactive substance such as complement, IFN, spleen weight reflects the immune state of body indirectly.Research display, irradiates comparison
Group mice spleen heavily significantly reduces, and gives the present invention Chinese medicine composition of high, medium and low dosage, significantly increases mice after irradiation
Spleen weight, the present invention is high, middle, and dosage group compares with irradiation control group, has significant difference.Result is as shown in table 2:
The impact on spleen of table 2 Chinese medicine composition of the present invention
Above experimental result shows indirectly, and the Chinese medicine composition of the present invention can improve body immunity, thus prevents and treats radiation, fall
Low emissivity endangers.
The foregoing is only the optimal case study on implementation of the present invention, be merely illustrative for the purpose of the present invention, and unrestricted
Property.Those skilled in the art understands, it can be carried out some and revise in the scope of the claims in the present invention, but all
To fall within the scope of protection of the present invention.
Claims (6)
1. the Chinese medicine composition of the preventing and treating radiation containing Rhizoma Chuanxiong, it is characterised in that described Chinese medicine composition is adopted with the following method
Preparation: with Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Curcumae, Fructus Psoraleae, Folium Ginkgo as raw material, shreds raw material, mixes, use ethanol water
Solution decocts, and decoction liquor filters, and concentrating under reduced pressure obtains the mastic of thickness, obtains described Chinese medicine composition.
Chinese medicine composition the most according to claim 1, it is characterised in that the consumption of each raw material is: Rhizoma Chuanxiong 25-35 part, Radix Angelicae Sinensis
10-20 part, Radix Astragali 10-15 part, Rhizoma Curcumae 8-12 part, Fructus Psoraleae 5-10 part, Folium Ginkgo 1-5 part.
3. according to the Chinese medicine composition described in claim 1-2, it is characterised in that the consumption of each raw material is: Rhizoma Chuanxiong 25-30 part, when
Return 15-18 part, Radix Astragali 10-15 part, Rhizoma Curcumae 10-12 part, Fructus Psoraleae 5-8 part, Folium Ginkgo 3-5 part.
4. according to the Chinese medicine composition described in claim 1-3, it is characterised in that the consumption of each raw material is: Rhizoma Chuanxiong 27 parts, Radix Angelicae Sinensis
16 parts, the Radix Astragali 12 parts, Rhizoma Curcumae 10 parts, Fructus Psoraleae 5 parts, Folium Ginkgo 3 parts.
5. according to the Chinese medicine composition described in claim 1-4, it is characterised in that described ethanol water is 70-85% ethanol, second
Alcohol-water solution volumetric usage is 6-10 times of raw medicinal material weight.
6. according to the Chinese medicine composition described in claim 1-5, it is characterised in that ethanol water volumetric usage is raw material weight
8 times.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610487405.1A CN105902970A (en) | 2016-06-29 | 2016-06-29 | Chuanxiong rhizome-containing traditional Chinese medicine composition for preventing and treating radiation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610487405.1A CN105902970A (en) | 2016-06-29 | 2016-06-29 | Chuanxiong rhizome-containing traditional Chinese medicine composition for preventing and treating radiation |
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| CN105902970A true CN105902970A (en) | 2016-08-31 |
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| CN201610487405.1A Pending CN105902970A (en) | 2016-06-29 | 2016-06-29 | Chuanxiong rhizome-containing traditional Chinese medicine composition for preventing and treating radiation |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN102389511A (en) * | 2011-11-22 | 2012-03-28 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation Chinese medicine preparation and preparation method thereof |
| CN104840722A (en) * | 2015-05-27 | 2015-08-19 | 苏笮斌 | Functional health-preserving treasure composition as well as preparation method and application method thereof |
-
2016
- 2016-06-29 CN CN201610487405.1A patent/CN105902970A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1160560A (en) * | 1996-03-21 | 1997-10-01 | 廖柏松 | Chinese patent drug for curing leukopenia and its preparation process |
| CN102389511A (en) * | 2011-11-22 | 2012-03-28 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation Chinese medicine preparation and preparation method thereof |
| CN104840722A (en) * | 2015-05-27 | 2015-08-19 | 苏笮斌 | Functional health-preserving treasure composition as well as preparation method and application method thereof |
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