CN109512857A - A kind of mannose-Chinese herbal compounds inhibiting tumour growth - Google Patents

A kind of mannose-Chinese herbal compounds inhibiting tumour growth Download PDF

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Publication number
CN109512857A
CN109512857A CN201811437882.2A CN201811437882A CN109512857A CN 109512857 A CN109512857 A CN 109512857A CN 201811437882 A CN201811437882 A CN 201811437882A CN 109512857 A CN109512857 A CN 109512857A
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China
Prior art keywords
mannose
growth
chinese herbal
tumour cell
herbal compounds
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CN201811437882.2A
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Chinese (zh)
Inventor
李同金
赵传海
周勇
李倩
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Shandong Han Peptide Biomedical Co ltd
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Shandong Hantai Biotechnology Co Ltd
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Priority to CN201811437882.2A priority Critical patent/CN109512857A/en
Publication of CN109512857A publication Critical patent/CN109512857A/en
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    • A21D13/00—Finished or partly finished bakery products
    • A21D13/06—Products with modified nutritive value, e.g. with modified starch content
    • A21D13/062—Products with modified nutritive value, e.g. with modified starch content with modified sugar content; Sugar-free products
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/36—Vegetable material
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
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Abstract

The present invention relates to field of medicaments, the present invention uses mannose-Chinese herbal compounds, can effectively inhibit the growth of tumour cell, and it can make tumor patient avoid chemicotherapy bring side reaction, extend the life expectancy of tumor patient with hypotoxicity.Compound preparation is made in mannose and Chinese medicine of strengthening the body resistance to consolidate the constitution by mannose-Chinese herbal compounds, can be prevented the glucose metabolism of tumour cell, be cut off its energy source, while can improve the immunity of tumor patient itself again, to inhibit the fast-growth of tumour cell.

Description

A kind of mannose-Chinese herbal compounds inhibiting tumour growth
Technical field
The present invention relates to field of medicaments, in particular to a kind of mannose-Chinese herbal compounds for inhibiting tumour growth.
Technical background
Tumour (tumour) refers to body under the effect of the various tumorigenesis factors, and local organization hyperplasia is formed by new life Object (neogrowth), because this neoformation is in occupancy block-like protrusions more, also referred to as neoplasm (neoplasm).According to new life The cell characteristics of object and harmfulness degree to body, and tumour is divided into benign tumour and malignant tumour two major classes.It is pernicious swollen Tumor is to endanger a kind of disease of human health most serious at present, and morbidity and mortality are obviously rising.Inhomogeneity at present The research and treatment of the malignant tumour of type have different degrees of progress, but therapeutic effect is bad at this stage, poor prognosis, are the mankind The problem not yet captured in medical domain.
It is the most important biological characteristics of malignant tumour with local infiltration and DISTANT METASTASES IN ability.The growth of various tumours Speed has bigger difference, depends primarily on the differentiation and maturation degree of tumour cell.The growth of tumour cell needs a large amount of energy, They are also required to the common participation of nucleic acid, fatty acid and amino acid simultaneously.The generation that tumour cell passes through these important components of adjusting It thanks to meet the needs of bio-energy and biosynthesis.It prevents tumour cell from obtaining the energy that growth needs, separates it and given birth to Nucleic acid necessary to long, fatty acid and amino acid, it will be able to inhibit the continued growth of tumour.
Current cancer therapies mostly use the complex treatment based on radiation and chemotherapy, but effect is ideal not to the utmost.Radiotherapy is difficult to root Except the tumour cell of transfer, chemotherapy non-selectivity, so that drug also damages normal cell while killing cancer cell. Consequently, it is desirable to seek new effective chemotherapy regimen to solve the problems, such as this.
Those skilled in the art still expect have new method to inhibit growth of tumour cell, especially expect there is new combination Object as health care, medical treatment, medicine purposes, for inhibiting growth of tumour cell.
Summary of the invention
The purpose of the present invention is to provide a kind of mannose-Chinese herbal compounds for inhibiting tumour growth, can be used in inhibiting Growth of tumour cell.It is found experimentally that the function of excellent inhibition growth of tumour cell is presented in prescription resulting composition of the present invention Can, and one or more excellent technical effects are presented.
For this purpose, first aspect present invention provide it is a kind of for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, Contain mannose in complex components and consolidates Fuzheng herbs ingredient.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that multiple Mannose quality accounting is between 5% to 95% in conjunction object.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that multiple Close object in consolidate Fuzheng herbs ingredient can be ginseng, Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Chinese yam, radix rehmanniae preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, the fleece-flower root, Ah Glue, tortoise version, Radix Rehmanniae, the root of straight ladybell, Radix Ophiopogonis, fructus lycii, the fruit of glossy privet, asparagus fern, radix scrophulariae, cortex cinnamomi, Herba Cistanches, thizoma curculiginis, HERBA EPIMEDII, Psoralen One or more of rouge, Semen Cuscutae, Cortex Eucommiae, Rabdosia amethystoides.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that multiple Closing and consolidating Fuzheng herbs ingredient in object is Radix Astragali, Radix Codonopsis, the fruit of glossy privet.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that multiple Closing and consolidating Fuzheng herbs ingredient in object is Radix Glycyrrhizae, oldenlandia diffusa, ganoderma lucidum, hedgehog hydnum, mushroom.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that multiple Closing and consolidating Fuzheng herbs ingredient in object is Chinese yam, jujube, walnut kernel, Semen sesami nigrum, longan.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that its In the form of tablet, capsule, oral solution, soft capsule, powder, tincture, powder-injection, liquid drugs injection, primary infusion.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that multiple It closes and also contains magnesium stearate, starch, microcrystalline cellulose, Opadry in object.
Mannose-the Chinese herbal compounds for being used to inhibit growth of tumour cell according to a first aspect of the present invention, it is preferred that its In biscuit, soft sweets, cream food form.
Relative to existing drug, the beneficial effects of the present invention are:
Mannose-Chinese herbal compounds in the present invention, can effectively inhibit the growth of tumour cell, and it is with low Toxicity can make tumor patient avoid chemicotherapy bring side reaction, extend the life expectancy of tumor patient.
Detailed description of the invention
Attached drawing 1 is the comparative diagram that the embodiment of the present invention inhibits tumour growth,
Attached drawing 2 is the comparative diagram that the embodiment of the present invention improves tumor-bearing mice curative effect.
Specific embodiment
The present invention can be further described by the following examples, however, the scope of the present invention and unlimited In following embodiments.One of skill in the art, can be with it is understood that under the premise of without departing substantially from the spirit and scope of the present invention Various change and modification are carried out to the present invention.The present invention carries out the material and test method arrived used in test general And/or specific description.Although to realize the present invention many materials and operating method used in purpose be it is known in the art that But the present invention is still described in this detail as much as possible.
Embodiment 1: the preparation of Chinese medical extract
20kg Radix Astragali is weighed, is crushed, 80 meshes are crossed.It is added flooding 3 times of 10 times of volumes, 5 hours every time, merges extraction Liquid obtains Aqueous extracts.Residual residue adds 3 by 80% ethyl alcohol of volume, and refluxing extraction 3 times, 3 hours every time, combined extract obtained alcohol extracting Liquid.Alcohol extract and Aqueous extracts merge, and are dried under reduced pressure, obtain Huang Shi extract.
The 20kg fruit of glossy privet is weighed, is crushed, 80 meshes are crossed.It is added flooding 3 times of 10 times of volumes, 5 hours every time, merges leaching Extract obtains Aqueous extracts.Residual residue adds 3 by 80% ethyl alcohol of volume, and refluxing extraction 3 times, 3 hours every time, combined extract obtained alcohol Extract.Alcohol extract and Aqueous extracts merge, and are dried under reduced pressure, obtain glossy privet fruit extract.
20kg Radix Codonopsis is weighed, is crushed, 80 meshes are crossed.It is added flooding 3 times of 10 times of volumes, 5 hours every time, merges extraction Liquid obtains Aqueous extracts.Residual residue adds 3 by 80% ethyl alcohol of volume, and refluxing extraction 3 times, 3 hours every time, combined extract obtained alcohol extracting Liquid.Alcohol extract and Aqueous extracts merge, and are dried under reduced pressure, obtain Radix Codonopsis extract.
Ginseng, Rhizoma Atractylodis Macrocephalae, Chinese yam, radix rehmanniae preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, the fleece-flower root, donkey-hide gelatin, tortoise version, Radix Rehmanniae, the root of straight ladybell, wheat is made in same method Winter, fructus lycii, asparagus fern, radix scrophulariae, cortex cinnamomi, Herba Cistanches, thizoma curculiginis, HERBA EPIMEDII, psoralea corylifolia, Semen Cuscutae, Cortex Eucommiae, the single of Rabdosia amethystoides mention Take object.
Embodiment 2: mannose-Chinese herbal compounds particle is prepared
Take 1kg parts of mannose, Astragalus Root P.E 0.2g, glossy privet extract 0.2kg.It is sufficiently mixed, crosses 150 meshes, be added Appropriate 20% PVP K30 solution.Softwood processed.Softwood sieving granulation, 60 DEG C of dryings, pelletizing machine whole grain obtain granule.
Embodiment 3: mannose-Chinese herbal compounds capsule is prepared
Take 1kg parts of mannose, Astragalus Root P.E 0.2g, glossy privet extract 0.2kg.It is sufficiently mixed, crosses 150 meshes, be added Appropriate 20% PVP K30 solution.Softwood processed.Softwood sieving granulation, 60 DEG C of dryings, pelletizing machine whole grain obtain particle, then will Particle crushes, and crosses 150 meshes, is packed into No. 1 capsulae vacuus, obtains capsule.
Embodiment 4: mannose-Chinese herbal compounds oral solution is prepared
Take 1kg parts of mannose, Astragalus Root P.E 0.2g, glossy privet extract 0.2kg.It is sufficiently mixed, crosses 150 meshes, be added Recipe quantity purified water, pigment, corrigent, preservative dissolution, are filtered, packing, and 120 DEG C of pressure sterilizings 20 minutes to get in oral The composition of liquid form.Per bottled 20ml.
Embodiment 5: preparation is containing mannose-Chinese herbal compounds biscuit
2 parts of mannose, 9 parts of flour, 1 part of Astragalus Root P.E, salt appropriate amount of edible oil.
Biscuit is prepared as according to cake preparation method.
Embodiment 6: anxious poison experiment
It takes example 4 that oral solution is made to obtain, carries out anxious poison experiment, the experiment of nursing in 30 days and the experiment of nursing in 90 days.The results show that Compound provided by the invention is safe and non-toxic.Feed growth of animal is good, through blood test, biochemical analysis no abnormality seen, Each Viscera index and histological examination no abnormality seen.It can be seen that the invention be related to compound is safe and non-toxic, be suitble to long-term consumption.
Embodiment 7: antitumor zoopery
Referring to attached drawing 1, the embodiment of the present invention inhibits the comparative diagram of tumour growth, and experiment is carried out using tumor-bearing mice.Blank Administration group is as control.According to 5,10,15,20,25,30,35,40 days time point anatomic measurement gross tumor volumes.As can be seen that this What invention provided, which meets object, can significantly inhibit the growth of tumour.
Embodiment 8: antitumor zoopery
Referring to attached drawing 2, the embodiment of the present invention improves the comparative diagram of tumor-bearing mice curative effect.Experiment using tumor-bearing mice into Row.Blank administration group is as control.40 days or so, there is experimental animal to start death, starts to calculate survival rate.Experimental result is aobvious Show, administration group significantly improves tumor-bearing mice survival rate.

Claims (9)

1. a kind of for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that contain in complex components Mannose and consolidate Fuzheng herbs ingredient.
2. according to claim 1 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that Mannose quality accounting is between 5% to 95% in compound.
3. according to claim 1 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that Consolidated in compound Fuzheng herbs ingredient can be ginseng, Radix Codonopsis, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Chinese yam, radix rehmanniae preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, the fleece-flower root, Donkey-hide gelatin, tortoise version, Radix Rehmanniae, the root of straight ladybell, Radix Ophiopogonis, fructus lycii, the fruit of glossy privet, asparagus fern, radix scrophulariae, cortex cinnamomi, Herba Cistanches, thizoma curculiginis, HERBA EPIMEDII, Psoralen One or more of rouge, Semen Cuscutae, Cortex Eucommiae, Rabdosia amethystoides.
4. according to claim 3 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that It is Radix Astragali, Radix Codonopsis, the fruit of glossy privet that Fuzheng herbs ingredient is consolidated in compound.
5. according to claim 3 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that It is Radix Glycyrrhizae, oldenlandia diffusa, ganoderma lucidum, hedgehog hydnum, mushroom that Fuzheng herbs ingredient is consolidated in compound.
6. according to claim 3 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that It is Chinese yam, jujube, walnut kernel, Semen sesami nigrum, longan that Fuzheng herbs ingredient is consolidated in compound.
7. according to claim 1 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that It is in the form of tablet, capsule, oral solution, soft capsule, powder, tincture, powder-injection, liquid drugs injection, primary infusion.
8. according to claim 1 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that Also contain magnesium stearate, starch, microcrystalline cellulose, Opadry in compound.
9. according to claim 1 for inhibiting mannose-Chinese herbal compounds of growth of tumour cell, which is characterized in that It is in biscuit, soft sweets, cream food form.
CN201811437882.2A 2018-11-29 2018-11-29 A kind of mannose-Chinese herbal compounds inhibiting tumour growth Pending CN109512857A (en)

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CN109846046A (en) * 2019-04-10 2019-06-07 山东汉泰生物科技有限公司 A kind of mannose-amino acid complex improving immunity
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Publication number Priority date Publication date Assignee Title
CN109846046A (en) * 2019-04-10 2019-06-07 山东汉泰生物科技有限公司 A kind of mannose-amino acid complex improving immunity
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