CN102366464B - Antitumor traditional Chinese medicine composition - Google Patents
Antitumor traditional Chinese medicine composition Download PDFInfo
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- CN102366464B CN102366464B CN201110360471.XA CN201110360471A CN102366464B CN 102366464 B CN102366464 B CN 102366464B CN 201110360471 A CN201110360471 A CN 201110360471A CN 102366464 B CN102366464 B CN 102366464B
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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Abstract
The invention relates to an antitumor traditional Chinese medicinal composition, which comprises the following bulk drugs by weight: 5-15 of Radix Astragali; 10-20 of ginseng; 5-10 of Coleus forskohli; 5-15 of ganoderma; 10-25 of barbed skullcap herb; 5-25 of hedyotis diffusa; and 5-10 of dried orange peel. The traditional Chinese medicinal composition of the invention has an obvious tumor inhibition effect, and is suitable for treating various malignant canceration including liver cancer, stomach cancer, kidney cancer, esophageal cancer, lung cancer, leukemia and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially relate to a kind of Chinese medicine composition with antitumor efficacy.
Background technology
Along with the impact of the various external environment conditions such as ecological degeneration and social pressure, malignant tumor is brought increasing trouble to people.Modern western medical treatment tumor adopts chemotherapy or radiation therapy more, when killing cancerous cell, also the many normal cells of human body is eliminated together, to patient, brings huge misery and mental pressure.
Summary of the invention
Technical problem solved by the invention is to provide a kind of Chinese medicine composition that can suppress killing off tumor cells, reduce cancer patient's misery.It utilizes Chinese medicine and modern preparation technique, overcomes the defect of western medical treatment malignant tumor, suppresses killing off tumor cells, reduces cancer patient painful, effectively extends their life span.
A Chinese medicine composition, count by weight crude drug and be:
The Radix Astragali: 5-15;
Radix Ginseng: 10-20;
Coleus forskohlii Briq.: 5-10;
Ganoderma: 5-15;
Herba Scutellariae Barbatae: 10-25;
Hedyotidis Diffusae: 5-25;
Pericarpium Citri Reticulatae: 5-10.
Chinese medicine composition of the present invention, wherein count by weight crude drug and be preferably:
The Radix Astragali: 6-10;
Radix Ginseng: 11-15;
Coleus forskohlii Briq.: 6-9;
Ganoderma: 8-13;
Herba Scutellariae Barbatae: 15-25;
Hedyotidis Diffusae: 10-25;
Pericarpium Citri Reticulatae: 6-10.
Chinese medicine composition of the present invention, wherein count by weight crude drug and most preferably be:
The Radix Astragali: 8;
Radix Ginseng: 12;
Coleus forskohlii Briq.: 6;
Ganoderma: 8;
Herba Scutellariae Barbatae: 16;
Hedyotidis Diffusae: 16;
Pericarpium Citri Reticulatae: 6.
Chinese medicine composition of the present invention, can be prepared into various form of Chinese drug, for clinical taking.Such as being capsule, pill, tablet, powder, injection and/or oral liquid etc.
Highly preferred capsule formulation wherein, its clinical taking convenience, effective ingredient absorbs fast, and the holding time is long, and production technology is simple, and a kind of preferred preparation method comprises the following steps:
(1) accurately weigh each component, put into the broken dispersal mechanism of compound high shear for nanometer powder;
(2) proceed to ultrasound wave blender, ultrasonic mixing is refrigerated to-18 ℃ after 30 minutes;
(3) mix homogeneously under 2 ℃ of following conditions;
(4) aseptic capsule charge after mistake 80 mesh sieves, makes.
Above-mentioned capsule formulation can adopt No. 1 hard capsule packing, about 430 milligrams of every contained content.Instructions of taking is every day 3 times, each 4.One after each meal general 28 days is a course for the treatment of.Suitable lucifuge, normal temperature storage, keeping.
Chinese medicine composition of the present invention and Chinese medicine preparation, through animal experiment and human clinical trial's checking, have the effect of obvious inhibition tumor, are applicable to comprise the treatment of the various pernicious cancerations such as hepatocarcinoma, gastric cancer, renal carcinoma, esophageal carcinoma, pulmonary carcinoma, leukemia.
Chinese medicine composition of the present invention is with reference to monarch, minister, the designed modern Chinese medicine of Chinese prescription principle helping, make.The effect of the crude drug adopting is as follows:
The Radix Astragali, another name: the continuous Radix Astragali etc., English name: Milkvetch Root, Chinese medicine latin name: RADIX ASTRAGALI; The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.Be usually used in the deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst.
Radix Ginseng, another name: SHANSHEN, Park Ginseng, people's rank, Herba Wedeliae Wallichii, Radix Ginseng etc., English name: Ginseng, Ginseng Root, Latin plant name: Panax ginseng C.A.Mey.; Have strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the effect of the Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly: impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the disease of all qi-blood-body fluid deficiencies.
Coleus forskohlii Briq. (Coleus forskolin Briq.) is Labiatae Coleus plant, entirely belongs to approximately 90 kinds, originates in subtropical zone, the Eastern Hemisphere, is mainly distributed in the ground such as India, Sri Lanka and Nepal.China has 6 kinds, main product Sichuan, Fujian and Taiwan.Coleus forskohlii Briq. is called as catholicon in India, at ancient Chinese, is called again Flos Colei esquirolii, is applied to relieving asthma, the approach such as spasmolytic, blood pressure lowering, antithrombotic, and is found to have at recent two decades the mystery effect that suppresses tumor.
Ganoderma, another name: Ganoderma lucidum (Leyss. Ex Fr.) Karst., red sesame, Ganoderma Lucidum, Ganoderma, Ganoderma lucisum, Ganoderma lucidum seu Japonicum, English name: LucidGanoderma, Latin formal name used at school: Ganoderma lucidum (Curtis:Fr) PKarst.; For Basidiomycetes Polyporaceae (Polyporaceae) Ganoderma (Ganodelma) fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. G.1ucidumkarst with the general name of Ganoderma G.japonicrn L loyd, there is the effects such as strengthening the body resistance.Ganoderma as medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma, and its property of medicine is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.
Herba Scutellariae Barbatae, another name head grass, narrow leaf Herba Scutellariae indicae, toothbrush grass, Herba Scutellariae Darbatae, Herba Carpesii Cernui, English name: HERBASCUTELLARIAEBARBATAE, latin name: Portulaca grandiflora Hook.; Herb and root for labiate Herba Scutellariae Barbatae.Cool in nature, mildly bitter flavor.Function is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema.Cure mainly venom, furuncle furuncle and phyma etc.
Hedyotidis Diffusae, has another name called Herba Hedyotidis Diffusae, Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia, Latin formal name used at school: Hedyotis diffusa; It is the plant of Rubiaceae cerastium.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestine meridian, clearing up internal heat by using drugs of bitter in taste and cold in nature removing toxic substances, sweet cold eliminating damp-heat, has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.
Pericarpium Citri Reticulatae, another name: Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, wide Pericarpium Citri tangerinae, Pericarpium Citri tangerinae, Citrus chachiensis Hort. C. Suavissima Tanaka, Pericarpium citri reticuatae chachiensis.Mature peel for rutaceae orange and variety thereof.Variety mainly contains Citrus reticulata Blanco cv. Chachiensis Citrus reticulata ' Chachi ' (Pericarpium citri reticuatae chachiensis), Radix Campylotropis Hirtella (Herba Myrsines Africanae) Citrus reticulata ' Dahongpao ', satsuma orange Citrus reticulata ' Unshiu ', tangerine produced in fujian province Citrus reticulata ' Tangerina '.The effect of appetizing in tool regulating QI and lowering the adverseness, tune, drying dampness to eliminate phlegm.
The present invention be take Coleus forskohlii Briq. as major function composition, is aided with Ganoderma, the Radix Astragali, Radix Ginseng, Herba Scutellariae Barbatae, Hedyotidis Diffusae etc. Chinese medicine is composite to form, and except having the effect of killing off tumor cells, also has the effect of strengthening the body resistance, comprehensively regulating.Meanwhile, raw materials used medicine is all Chinese medicine composition, and its consumption is all within pharmacopeia and national standard scope, and toxic and side effects is less.
Raw material required for the present invention, equipment all have commercially available.
The specific embodiment
For further illustrating the present invention, illustrate with the following Examples:
Chinese medicine preparation of the present invention is preferably capsule formulation, and preparation method comprises the following steps:
(1) accurately weigh each component, put into the broken dispersion machine of compound high shear (Shanghai Suowei Electromechanical Equipment Co., Ltd.) and prepare nanometer powder;
(2) proceed to ultrasound wave blender, ultrasonic mixing is refrigerated to-18 ℃ after 30 minutes;
(3) mix homogeneously under 2 ℃ of following conditions;
(4) aseptic capsule charge after mistake 80 mesh sieves, makes.
Embodiment 1:
The Herbal compound capsule of preparation as stated above, the first step wherein, the weight proportion of each crude drug is as follows: Radix Astragali 8g, Radix Ginseng 12g, Coleus forskohlii Briq. 6g, Ganoderma 8g, Herba Scutellariae Barbatae 16g, Hedyotidis Diffusae 6g, Pericarpium Citri Reticulatae 6g.
Embodiment 2
The Herbal compound capsule of preparation as stated above, the first step wherein, the weight proportion of each crude drug is as follows: Radix Astragali 12g, Radix Ginseng 12g, Coleus forskohlii Briq. 9g, Ganoderma 12g, Herba Scutellariae Barbatae 20g, Hedyotidis Diffusae 6g, Pericarpium Citri Reticulatae 6g.
Embodiment 3
The Herbal compound capsule of preparation as stated above, the first step wherein, the weight proportion of each crude drug is as follows: Radix Astragali 8g, Radix Ginseng 12g, Coleus forskohlii Briq. 8g, Ganoderma 8g, Herba Scutellariae Barbatae 16g, Hedyotidis Diffusae 12g, Pericarpium Citri Reticulatae 6g.
Embodiment 4
The Herbal compound capsule of preparation as stated above, the first step wherein, the weight proportion of each crude drug is as follows: Radix Astragali 9g, Radix Ginseng 12g, Coleus forskohlii Briq. 8g, Ganoderma 12g, Herba Scutellariae Barbatae 16g, Hedyotidis Diffusae 12g, Pericarpium Citri Reticulatae 6g.
Embodiment 5
The Herbal compound capsule of preparation as stated above, the first step wherein, the weight proportion of each crude drug is as follows: Radix Astragali 9g, Radix Ginseng 12g, Coleus forskohlii Briq. 6g, Ganoderma 10g, Herba Scutellariae Barbatae 18g, Hedyotidis Diffusae 12g, Pericarpium Citri Reticulatae 6g.
Embodiment 6
The Herbal compound capsule of preparation as stated above, the first step wherein, the weight proportion of each crude drug is as follows: Radix Astragali 8g, Radix Ginseng 12g, Coleus forskohlii Briq. 9g, Ganoderma 12g, Herba Scutellariae Barbatae 18g, Hedyotidis Diffusae 10g, Pericarpium Citri Reticulatae 6g.
Test example:
1, animal acute toxicological experiment:
The acute toxicological experiment result made of kunming mouse shows, with 1 times, 10 times, the crude drug composition of the medicine of the embodiment of 30 multiple doses, fills with respectively and raises mice one month, and death condition does not all appear in the experimental group of three dosage and matched group; Dissect animal tissue and observe, the experimental group of high, medium and low three dosage is compared with blank group, and animal tissue's form does not have notable difference.
2, Long term Animal toxicological experiment
With SD, be that the crude drug composition of medicine of the embodiment of 35.4 times of the maximum dosages of rat and long-term toxicological experiment and the 10 multiple doses SD that feeds is rat, filling is raised mice three months respectively, and death condition does not all appear in experimental group and matched group; Dissect animal tissue and observe, experimental group is compared with blank group, and animal tissue's form does not have notable difference.
3, pharmacological evaluation:
The present invention adopt respectively conventional tumor suppression Research on experimental methods the crude drug composition of medicine of the embodiment of the present invention to human osteosarcoma cell (UMR106, MG63), human promyelocytic leukemia cell (HL60, NB4), human erythroleukemia cell (K562), mouse S 180 sarcoma and the growth inhibited of human lung adenocarcinoma cell (PG), human nasopharyngeal carcinoma (CNE) etc. and the observation of cellular morphology structural change, comprise and measured growth curve, di; The metamorphosis of observing under optical microscope, scanning electron microscope and transmission electron microscope; The variation of cell phenotype, subcellular structure and cytoskeleton etc.; The impact of medicine on Cancer Cell cycle; The impact of cell membrane mobility and the mensuration of transmembrane potential etc.Also adopt conventional tumor suppression experimental technique to do following experiment:
1, the tumor suppression experiment to animal transplanting tumor: the tumor suppression experiment to mouse S 180 sarcoma and mice Ehrlich ascites cells transplanted tumor;
2, human tumor is transplanted the tumor suppression experiment of nude mice: the tumor suppression experiment of human promyelocytic leukemia cell (HL60, NB4), human nasopharyngeal carcinoma (CNE-2) cell, human colon cancer cell (CA-II), people's gastric adenocarcinoma cells (BGC-823) and human lung carcinoma cell (PG) being transplanted to nude mice.
More than test all with the positive contrast of retinoic acid, the results show, Chinese medicine composition cancer suppressing ratio provided by the invention is between 31%～70%, and wherein best to human promyelocytic leukemia, people's adenocarcinoma of stomach and human nasopharyngeal carcinoma effect, cancer suppressing ratio is 60%～70%.
4, clinical trial
On zooperal basis, carry out pre-clinical research: under doctor's proper intensive care, instruct aspiration pill taker on probation.
1, the preliminary pre-clinical research for the treatment of human leukemia, according to < < World Health Organization Classification of Tumors.Pathology and Genetic of Tumors of Haematopoietic and Lymphoid Tissue > > (2008), < < diagnosis of hematological diseases and the criterion of therapeutical effect > > (south of opening, Shen Ti chief editor, Science Press, 2008, the third edition), we have carried out the detection of following three aspects:: (1) health check-up has or is difficult lower sign: generate heat, mucocutaneous pale, dermatorrhagia point and ecchymosis, lymph node and hepatosplenomegaly, breastbone tenderness etc.(2) Blood cell counting and classification.(3) bone marrow examination: morphology (comprising groupization inspection).Enter to organize altogether patient's 12 examples, about 430 milligrams of every contained content of Herbal compound capsule of embodiment 1.Instructions of taking is every day 3 times, each 4.One after each meal, take 28 days as a course for the treatment of, and through the treatment of 3 courses for the treatment of, improvement rate is 83.33%, and obvious effective rate is 58.33%.Result confirms that herbal mixture of the present invention is to children's grain type leukemia successful morning.
2, the pre-clinical research for the treatment of people late gastric cancer, according to Ministry of Public Health < < gastric cancer diagnosis and treatment standard > >, enter to organize altogether patient's 26 examples, about 430 milligrams of every contained content of Herbal compound capsule of embodiment 2.Instructions of taking is every day 3 times, each 4.One after each meal, take 28 days as a course for the treatment of, and through the treatment of 4 courses for the treatment of, improvement rate (PR) is 30.77%, and stable (SD) rate is 65.38%, and (PD) rate of deterioration is 3.85%.Result confirms that herbal mixture of the present invention is having positive effect (lymph node dwindles, appetite increase etc. for atrophy as softening in tumor, ascites disappearance) aspect the quality of making the life better.
3, the pre-clinical research of herbal mixture treatment advanced renal cell cancer of the present invention, according to solid tumor efficacy assessment standard (RECIST), enters to organize patient's 11 examples, about 430 milligrams of every contained content of Herbal compound capsule of embodiment 3 altogether.Instructions of taking is every day 3 times, each 4.One after each meal, take 56 days as a course for the treatment of, and through the treatment of 3 courses for the treatment of, improvement rate (PR) is 27.27%, and stable (SD) rate is 54.55%, and (PD) rate of deterioration is 18.18%.
Model case:
1, Wang, female, 78 years old, in JIUYUE, 2010, hemoptysis after patient catches a cold.When household is with its health check-up next day, CT examination finds that it is pulmonary carcinoma that there is one 3.5 * 4cm shade ，Jing Yantai City North Sea hospital diagnosis in pulmonary.On April 30th, 2011, patient starts to take herbal mixture described in the embodiment of the present invention 1, and through the treatment of 3 courses for the treatment of, in January, 2011, household is with it again to check, and CT examination result is that pulmonary shadow dwindles.Patient feels well, increases, and can do general housework than former appetite.
2, Zeng, female, 54 years old, in November, 2010, NUS's medical college was diagnosed as breast carcinoma, excise after left mammary gland, western medical treatment DeGrain, and lose hair seriously, sleep bad.From in June, 2011, start to take herbal mixture described in the embodiment of the present invention 2, through taking 2 courses for the treatment of, patient body is in good condition, has no recurrence.The mental status is also taken on an entirely new look, and sleep quality is greatly improved.
3, Yin so-and-so, man, 69 years old, the People's Hospital, Qixia City in August, 2010 was diagnosed as later period of hepatocarcinoma, ascites is serious, patient is very painful.After multidigit chief physician's consultation of doctors, conclude that the survival of patients time can period of greater than two months.From in JIUYUE, 2010, start to take herbal mixture described in the embodiment of the present invention 3, through taking 5 courses for the treatment of, ascites reduces, and slight illness alleviates, but dies of illness in hospital in February, 2011.By taking herbal mixture of the present invention, effective life span of patient has extended about 3 months.
Above-described embodiment is described the preferred embodiment of the present invention; not scope of the present invention is limited; design under the prerequisite of spirit not departing from the present invention; various distortion and improvement that the common engineers and technicians in this area make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (8)
1. an antineoplastic Chinese medicine composition, is characterized in that: counting by weight crude drug is:
The Radix Astragali: 5-15;
Radix Ginseng: 10-20;
Coleus forskohlii Briq.: 5-10;
Ganoderma: 5-15;
Herba Scutellariae Barbatae: 10-25;
Herba Hedyotidis Diffusae: 5-25;
Pericarpium Citri Reticulatae: 5-10.
2. Chinese medicine composition according to claim 1, is characterized in that: counting by weight crude drug is:
The Radix Astragali: 6-10;
Radix Ginseng: 11-15;
Coleus forskohlii Briq.: 6-9;
Ganoderma: 8-13;
Herba Scutellariae Barbatae: 15-25;
Herba Hedyotidis Diffusae: 10-25;
Pericarpium Citri Reticulatae: 6-10.
3. Chinese medicine composition according to claim 1, is characterized in that: counting by weight crude drug is:
The Radix Astragali: 8;
Radix Ginseng: 12;
Coleus forskohlii Briq.: 6;
Ganoderma: 8;
Herba Scutellariae Barbatae: 16;
Herba Hedyotidis Diffusae: 6;
Pericarpium Citri Reticulatae: 6.
4. the Chinese medicine preparation of being made by the Chinese medicine composition described in claim 1-3 any one, is characterized in that: described preparation is capsule, pill, tablet, powder, injection or oral liquid.
5. Chinese medicine preparation according to claim 4, is characterized in that: described preparation is capsule.
6. the preparation method of Chinese medicine preparation claimed in claim 5, is characterized in that: comprise the following steps:
(1) accurately weigh each crude drug, put into the broken dispersal mechanism of compound high shear for nanometer powder;
(2) proceed to ultrasound wave blender, ultrasonic mixing is refrigerated to-18 ℃ after 30 minutes;
(3) mix homogeneously under 2 ℃ of following conditions;
(4) aseptic capsule charge after mistake 80 mesh sieves, makes.
7. the application of the Chinese medicine composition described in claim 1-3 any one in the medicine of preparation treatment tumor disease, is characterized in that: described tumor disease is hepatocarcinoma, gastric cancer, pulmonary carcinoma, leukemia, breast carcinoma.
8. the application of Chinese medicine preparation claimed in claim 4 in the medicine of preparation treatment tumor disease, is characterized in that: described tumor disease is hepatocarcinoma, gastric cancer, pulmonary carcinoma, leukemia, breast carcinoma.
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| CN104189287B (en) * | 2014-09-15 | 2018-02-06 | 秦银忠 | It is a kind of to be used to treat Chinese medicine preparation of kidney and preparation method thereof |
| CN104435544A (en) * | 2014-11-18 | 2015-03-25 | 焦宁 | Traditional Chinese medicine oral liquid for treating leukemia through being cooperated with chemotherapy and preparation method thereof |
| CN105031301A (en) * | 2015-08-24 | 2015-11-11 | 周伟刚 | Anti-tumor traditional Chinese medicine composition and preparation method thereof |
| CN106038818B (en) * | 2016-08-03 | 2019-04-09 | 牡丹江医学院 | It is a kind of for treating the Chinese medicine composition of kidney |
| CN106236975A (en) * | 2016-10-31 | 2016-12-21 | 夏蕾 | The Chinese medicine of anti-curing oncoma and preparation method |
| CN107412391A (en) * | 2017-05-25 | 2017-12-01 | 刘扬帆 | A kind of antineoplastic |
| CN107823610A (en) * | 2017-12-05 | 2018-03-23 | 武振玉 | Antineoplastic pharmaceutical compositions and preparation method thereof |
| CN108607012A (en) * | 2018-08-15 | 2018-10-02 | 林天东 | A kind of anti-hepatitis virus, antitumor Chinese medicine composition and its preparation and application |
| CN110193050A (en) * | 2019-07-09 | 2019-09-03 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine composition for preventing recurrence and metastasis of digestive tract tumor and preparation method thereof |
| CN110755546A (en) * | 2019-11-29 | 2020-02-07 | 朱成 | Traditional Chinese medicine composition for preventing cancer mutation |
| CN116159119A (en) * | 2023-02-27 | 2023-05-26 | 武汉京鄂同普医院有限责任公司 | Pure traditional Chinese medicine preparation with strengthening body resistance and resisting cancer effect and preparation method thereof |
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