CN102369942B - Oxinecopper and prochloraz containing pesticide composition - Google Patents
Oxinecopper and prochloraz containing pesticide composition Download PDFInfo
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- CN102369942B CN102369942B CN 201110318644 CN201110318644A CN102369942B CN 102369942 B CN102369942 B CN 102369942B CN 201110318644 CN201110318644 CN 201110318644 CN 201110318644 A CN201110318644 A CN 201110318644A CN 102369942 B CN102369942 B CN 102369942B
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- prochloraz
- copper
- hydroxyquinolinate
- oxinecopper
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Abstract
The invention discloses an oxinecopper and prochloraz containing pesticide composite which comprises oxinecopper, prochloraz and common additives, wherein the pbm (parts-by-mass) ratio of oxinecopper to prochloraz is (30:1)-(1:15), preferably (20:1)-(1:5). After the oxinecopper and the prochloraz are compounded, an obvious synergistic effect is achieved, and the dosages of the effective ingredients of the compounded medicament are significantly less than those of oxinecopper and prochloraz which are used singly. The pesticide composite disclosed by the invention is suitable to be used for preventing and controlling most of fungal diseases, especially apple alternaria leaf spot.
Description
Technical field
The present invention relates to composition pesticide, is to be active ingredient with copper 8-hydroxyquinolinate and Prochloraz, is applicable to the control crop fungal disease on the agricultural.
Background technology
In the crop growth process, be subjected to various diseases easily and contaminate, it is serious to cause harm, and for a long time, chemical control is to prevent and treat the main effective means of disease.Yet single drug and non-science medication has in recent years caused multiple pathogen that the agricultural chemicals of current use has been produced resistance, and is very general as pesticide resistance such as anthracnose, spot defoliation, banded sclerotial blights, becomes a great problem of chemical control.Because germ develops immunity to drugs, frequent dispenser causes peasant burden to increase the weight of and increasing environmental pollution again, in some disease serious zone takes place, and conventional pesticide uses separately and is difficult to control, and poor effect, has had a strong impact on agriculture benefit.Therefore, for overcoming the pesticide resistance of germ, be badly in need of the bactericide new varieties of efficient, low toxicity, safety, environmental protection.
Copper 8-hydroxyquinolinate, english common name oxine-copper.Novel organic copper series bactericidal agent is generated by 8--oxyquinoline and copper sulphate reaction, and organic quinoline and mantoquita have the double sterilization effect; G-protein synthetic that can suppress the getting up early cellular expression, suppress the metabolism of germ spore, the control cell divides once more and breaks up, it is active to have the multiple spot contact again concurrently, the pathogen spore that utilizes chelated copper to be sprouted absorbs, directly at the inner killing spores cell of pathogen, thereby reach the effect of preventing and curing diseases.Crop all had by fungi, bacterial multiple diseases kill significantly and inhibitory action.
Prochloraz, english common name prochloraz.The imidazoles broad-spectrum germicide.Cause effect by the biosynthesis that suppresses sterol, though do not have a systemic action, it has certain conductive performance, and the various crop disease that causes for sac fungi and imperfect fungus has special efficacy.But, also be faced with the pesticide resistance problem because Prochloraz uses for many years.
Summary of the invention
In order to satisfy the needs of agricultural production, make full use of two kinds of composite synergistic effects that produce of active component, improve preventive effect and delay the speed that the germ pesticide resistance produces, the present invention proposes a kind of efficient, low toxicity, environmental protection and help the Fungicidal composition of germ resistance management, the disease that is used to prevent and treat fruit tree, vegetables, cereal crops etc.
For addressing the above problem, the inventor finds that by a large amount of biologicall test screenings copper 8-hydroxyquinolinate and Prochloraz are composite with certain proportion, and antagonism property of medicine alternaria leaf spot of apple bacterium has significant synergies.
Composition pesticide of the present invention is characterised in that: with copper 8-hydroxyquinolinate and Prochloraz is active ingredient, and the ratio of quality and the number of copies of copper 8-hydroxyquinolinate and Prochloraz is 30:1～1:15, and preferred proportion is 20:1～1:5, and all the other are to allow in the agricultural chemicals to use and the acceptable auxiliary element.
Composition pesticide of the present invention is prepared into known method and is fit to any one formulation that agricultural goes up use, reasonable formulation is water dispersible granules, suspending agent, suspended emulsion, wetting powder, aqueous emulsion or microemulsion, and active ingredient gross mass mark percentage composition is 5%～80% in the preparation.
The auxiliary agent that uses in the composition pesticide of the present invention comprises that solvent, dispersant, stabilizing agent, emulsifier, antifreezing agent, thickener etc. and other are of value to active ingredient stablizes and bring into play drug effect in preparation known substance, all be the various compositions of using or allow use in the pesticidal preparations always, be not particularly limited, concrete composition and consumption require to determine by simple test according to prescription.
Composition pesticide described in the invention can provide with the form of finished product preparation, and promptly each material mixes in the composition, and the composition of composition also can provide with the form of single agent, directly mixes in jar or bucket before the use, is diluted to needed concentration then.The frequency of administration of the present composition and amount of application change with weather condition and crop state variation, can reach the purpose of control by using suitable formulation.
The present composition is applicable to prevents and treats the multiple kinds of crops disease, be mainly used in control, especially citrus anthracnose, watermelon anthrax, alternaria leaf spot of apple, ring rot of apple, rice sheath blight disease, early blight of tomato of fruit tree, vegetables, cereal crops disease etc.
Compared with prior art, beneficial effect of the present invention is: 1, composite have an obvious synergistic effect, improved control efficiency; 2, enlarged the control spectrum; 3, two kinds of active ingredients are composite, reduced the agricultural chemicals usage amount, thereby reduced cost and the pollution that has reduced environment.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage more short and sweet, the present invention describes with following specific embodiment, but the present invention only limits to these examples absolutely not.The following stated only is the present invention embodiment preferably, only is used to describe the present invention, can not be interpreted as the restriction to scope of the present invention.Should be pointed out that all any modifications of being made within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Biologicall test embodiment 1: the composite Toxicity Determination of copper 8-hydroxyquinolinate and Prochloraz to the alternaria leaf spot of apple bacterium.
The inventor is by a large amount of screening tests, the abundant method of utilization Sun Yun is carried out the synergistic effect analysis of different proportionings to copper 8-hydroxyquinolinate and Prochloraz composition, discovery is in certain ratio range, and copper 8-hydroxyquinolinate and Prochloraz combination alternaria leaf spot of apple bacterium have synergistic function.
Test material: pick up from the sick leaf of alternaria leaf spot of apple in field, standby after the separation and purification of laboratory.
Test method: with reference to NY/T 1156.6-2006.Promptly take by weighing the former medicine of 98% copper 8-hydroxyquinolinate of certain mass earlier, add chloroform and fully dissolve; With the former medicine of 97% Prochloraz, the Tween 80 aqueous solution with 0.1% after adding acetone fully dissolves dilutes, be mixed with single agent mother liquor respectively, according to the purpose that is mixed serial proportioning is set, each proportioning is provided with 5～7 concentration gradients, adopts mycelial growth inhibition method to carry out the Toxicity Determination of alternaria leaf spot of apple pathogen.Be placed in the aseptic culture case incubated at room temperature 7 days, and calculated control efficiency, then with method of least squares calculate suppress in dense EC
50(95% confidence limit)
,Calculate co-toxicity coefficient (CTC) with the abundant method of Sun Yun again.
Co-toxicity coefficient (CTC) 〉=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80＜co-toxicity coefficient (CTC)＜120 shows as summation action.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) * 100.
Theoretical toxicity index (TTI)=(percentage composition of A in toxicity index * mixture of A)+(percentage composition of B in toxicity index * mixture of B).
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI) the theoretical toxicity index (TTI) of mixture] * 100.
Measurement result shows that copper 8-hydroxyquinolinate and Prochloraz have obvious synergistic effect between proportioning 30:1～1:15, and especially between 20:1～1:5, synergistic effect is more obvious, and co-toxicity coefficient (is seeing Table 1) more than 180.
Table 1: different disposal is to the Toxicity Determination result of alternaria leaf spot of apple bacterium.
Bactericidal composition of the present invention can be made agricultural with known method and go up any one formulation of using, and reasonable formulation is water dispersible granules, suspending agent or suspended emulsion, wetting powder, aqueous emulsion or microemulsion.Below describe with specific embodiment.Percentage in the prescription is mass percent.The various preparation processing technologies of the present composition are prior art, can change to some extent according to different situations.
Example of formulations 1:40% copper 8-hydroxyquinolinate Prochloraz water dispersible granules.
Copper 8-hydroxyquinolinate 20%, Prochloraz 20%, lauryl sodium sulfate 6%, dispersant polycarboxylate 4%, disintegrant sodium chloride 2%, binding agent polyethylene glycol 3%, stabilizing agent soluble starch 3%,
Kaolin complements to 100%.Dry pulverization process, granulation, drying, screening preparation system promptly get 40% copper 8-hydroxyquinolinate Prochloraz water dispersible granules in proportion with above-mentioned prescription.
This embodiment is used to prevent and treat citrus anthracnose, 40% copper 8-hydroxyquinolinate Prochloraz water dispersible granules consumption 225g a.i./hm
2Convert water spray, 10 days preventive effects are 93.4% behind the medicine; 33.5% copper 8-hydroxyquinolinate suspending agent consumption 300g a.i./hm
2Convert water spray, 10 days preventive effects are 84.2% behind the medicine; 40% prochloraz aqueous emulsion consumption 300g a.i./hm
2Convert water spray, 10 days preventive effects are 83.1% behind the medicine.
The composite back synergy of copper 8-hydroxyquinolinate and Prochloraz is obvious, 40% copper 8-hydroxyquinolinate Prochloraz water dispersible granules control citrus anthracnose effect obviously is better than 33.5% copper 8-hydroxyquinolinate suspending agent and 50% prochloraz aqueous emulsion, because pharmacy control efficacy improves, the compound drug effective ingredient consumption reduces, so reduced drug cost, delay the generation of disease drug resistance, reduced environmental pollution.
Example of formulations 2: 30% copper 8-hydroxyquinolinate Prochloraz suspending agent.
Copper 8-hydroxyquinolinate 20%, Prochloraz 10%, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 3%, calcium dodecyl benzene sulfonate 3%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 2%, ethylene glycol 0.2%, xanthan gum 0.1%, organosilicon 0.4%, glycerine 5%, gum Arabic 0.1%, deionized water complements to 100%.
Above-mentioned prescription is pulverized in proportion in advance, added in the sand mill and grind, allotment makes 30% copper 8-hydroxyquinolinate Prochloraz suspending agent after high shear mixing.
This embodiment is used to prevent and treat early blight of tomato, 30% copper 8-hydroxyquinolinate Prochloraz suspending agent 260g a.i./hm
2Convert water spray, 12 days preventive effects are 91.5% behind the medicine.33.5% copper 8-hydroxyquinolinate suspending agent 300g a.i./hm
2Convert water spray, 12 days preventive effects are 82.2% behind the medicine.40% prochloraz aqueous emulsion consumption 270g a.i./hm
2Convert water spray, 12 days preventive effects are 83.6% behind the medicine, and copper 8-hydroxyquinolinate and the effect of Prochloraz compound synergic are obvious, and significantly better than single agent, the mixture effective ingredient consumption obviously reduces to the watermelon anthrax drug effect.
Example of formulations 3:30% copper 8-hydroxyquinolinate Prochloraz wetting powder.
Copper 8-hydroxyquinolinate 15%, Prochloraz 15% draws back powder 3%, naphthalenesulfonate formaldehyde condensation compound 6%, talcum powder 15%, kaolin complements to 100%.
Above-mentioned prescription entered in the blender after the coarse crushing in proportion mix, behind comminution by gas stream, promptly make 30% copper 8-hydroxyquinolinate Prochloraz wetting powder again.
This embodiment is used to prevent and treat alternaria leaf spot of apple, and 30% copper 8-hydroxyquinolinate Prochloraz wetting powder effective dose 120mg/kg converts water spray, and 14 days preventive effects are 94.0% behind the medicine.33.5% copper 8-hydroxyquinolinate suspending agent effective dose 150mg/kg converts water spray, and 14 days preventive effects are 85.5% behind the medicine.40% prochloraz aqueous emulsion effective dose 150mg/kg converts water spray, and 14 days preventive effects are 84.8% behind the medicine.Copper 8-hydroxyquinolinate and Prochloraz be composite to have obvious synergistic effect, and effective ingredient consumption obviously reduces.
Claims (1)
1. composition pesticide that contains copper 8-hydroxyquinolinate and Prochloraz, it is characterized in that being grouped into: copper 8-hydroxyquinolinate 20%, Prochloraz 10%, triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether 3% by the one-tenth of following quality percentage composition, calcium dodecyl benzene sulfonate 3%, alkylphenol polyoxyethylene formaldehyde condensation products sulphate 2%, ethylene glycol 0.2%, xanthan gum 0.1%, organosilicon 0.4%, glycerine 5%, gum Arabic 0.1%, deionized water complements to 100%; Above-mentioned prescription is pulverized in proportion in advance, added in the sand mill and grind, allotment makes 30% copper 8-hydroxyquinolinate Prochloraz suspending agent after high shear mixing.
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|---|---|---|---|
| CN 201110318644 CN102369942B (en) | 2011-10-19 | 2011-10-19 | Oxinecopper and prochloraz containing pesticide composition |
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|---|---|---|---|
| CN 201110318644 CN102369942B (en) | 2011-10-19 | 2011-10-19 | Oxinecopper and prochloraz containing pesticide composition |
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| CN102369942B true CN102369942B (en) | 2013-07-31 |
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| CN104756996B (en) * | 2015-04-17 | 2017-01-11 | 浙江海正化工股份有限公司 | Sterilization composition containing quinolone copper and ipconazole |
| CN109221234A (en) * | 2018-10-25 | 2019-01-18 | 中国农业科学院植物保护研究所 | A kind of composition and its application method with bactericidal activity |
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Effective date of registration: 20190805 Address after: 234000 Room 108, 4 Building, Xichang South Road Healthy Business Industrial Park, Shoe City Management Committee, Suzhou City, Anhui Province Patentee after: Anhui Huateng agricultural science and Technology Co. Ltd. Address before: 516000 Guangdong province Huizhou Zhongkai hi tech Development Zone No. 24 District Patentee before: Guangdong Zhongxun Agricultural Technology Co., Ltd. |
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Effective date of registration: 20191204 Address after: Room a86-28, floor 3, No. 18-24, Tianhe East Road, Tianhe District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Jiande agricultural science and Technology Co., Ltd. Address before: 234000 Room 108, 4 Building, Xichang South Road Healthy Business Industrial Park, Shoe City Management Committee, Suzhou City, Anhui Province Patentee before: Anhui Huateng Agricultural Technology Co., Ltd. |
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Effective date of registration: 20191223 Address after: No. 1006, Wenchang East Road, Jiangdu District, Yangzhou City, Jiangsu Province Patentee after: Jiangsu Changqing agrochemical Trade Co., Ltd Address before: Room a86-28, floor 3, No. 18-24, Tianhe East Road, Tianhe District, Guangzhou City, Guangdong Province Patentee before: Guangzhou Jiande agricultural science and Technology Co., Ltd. |
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