CN102365020B - 哒嗪酮化合物 - Google Patents
哒嗪酮化合物 Download PDFInfo
- Publication number
- CN102365020B CN102365020B CN201080014965.6A CN201080014965A CN102365020B CN 102365020 B CN102365020 B CN 102365020B CN 201080014965 A CN201080014965 A CN 201080014965A CN 102365020 B CN102365020 B CN 102365020B
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- substituted
- compound
- phenyl
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- ring
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- 0 *C1C(C2=NN(*3CCC(C4)C4C*CCC3)C(*)=C(*)C2=O)=CC=C1 Chemical compound *C1C(C2=NN(*3CCC(C4)C4C*CCC3)C(*)=C(*)C2=O)=CC=C1 0.000 description 24
- SHFIBWPYWIMLJA-UHFFFAOYSA-N CC(C(C(N=C)=O)=N)=O Chemical compound CC(C(C(N=C)=O)=N)=O SHFIBWPYWIMLJA-UHFFFAOYSA-N 0.000 description 1
- YUGLEFYERNROCN-UHFFFAOYSA-O CC(C(C=C1)[NH2+]C=CC(C(C(Nc2ccccc2)=CC=N)=N)=O)C=C1C(N)=O Chemical compound CC(C(C=C1)[NH2+]C=CC(C(C(Nc2ccccc2)=CC=N)=N)=O)C=C1C(N)=O YUGLEFYERNROCN-UHFFFAOYSA-O 0.000 description 1
- ZXZRZTQXIHOREW-QGRKOZDTSA-N CC(CC(C1C#CCCC(C2)c3cccc(C(F)(F)F)c3)C=[O](C)(C3)[C@H]3/C1=C/C2=O)=C Chemical compound CC(CC(C1C#CCCC(C2)c3cccc(C(F)(F)F)c3)C=[O](C)(C3)[C@H]3/C1=C/C2=O)=C ZXZRZTQXIHOREW-QGRKOZDTSA-N 0.000 description 1
- ODJBJHOBECSQFW-UHFFFAOYSA-N CC(CC1)CC(C2)C12c1c(C)c(N(C=C2OC)N=C(C3=CC=NC3C3=CC=CCC3)C2=C)ccc1 Chemical compound CC(CC1)CC(C2)C12c1c(C)c(N(C=C2OC)N=C(C3=CC=NC3C3=CC=CCC3)C2=C)ccc1 ODJBJHOBECSQFW-UHFFFAOYSA-N 0.000 description 1
- LOKIITTYQLGTGK-UHFFFAOYSA-N CCOc(cccc1)c1NN=C(C(C)=O)C(C)=O Chemical compound CCOc(cccc1)c1NN=C(C(C)=O)C(C)=O LOKIITTYQLGTGK-UHFFFAOYSA-N 0.000 description 1
- GPWXIOMUUOBXQB-UHFFFAOYSA-N CN(C(C(C(C(OC)=C1)=O)=NN1c1cccc(-c2c[n](C)nc2)c1F)=O)OC Chemical compound CN(C(C(C(C(OC)=C1)=O)=NN1c1cccc(-c2c[n](C)nc2)c1F)=O)OC GPWXIOMUUOBXQB-UHFFFAOYSA-N 0.000 description 1
- WFTLHMOKLNFUDI-UHFFFAOYSA-N CN(C)c1ccc(C(F)(F)F)cc1N(C=C1)N=C(c2ccn[n]2-c2ccccc2)C1=O Chemical compound CN(C)c1ccc(C(F)(F)F)cc1N(C=C1)N=C(c2ccn[n]2-c2ccccc2)C1=O WFTLHMOKLNFUDI-UHFFFAOYSA-N 0.000 description 1
- QQXHSCCLPNZGDD-UHFFFAOYSA-N COC(N(c1cc(C(F)(F)F)ccc1)N=C1c2ccn[n]2-c2ccccc2)=CC1=O Chemical compound COC(N(c1cc(C(F)(F)F)ccc1)N=C1c2ccn[n]2-c2ccccc2)=CC1=O QQXHSCCLPNZGDD-UHFFFAOYSA-N 0.000 description 1
- FGMDUUOMAJWHGW-UHFFFAOYSA-N COC1=CN(c(cc(cc2)-[n]3nccc3)c2F)N=C(c2ccn[n]2C2=CC=CCC2)C1=C Chemical compound COC1=CN(c(cc(cc2)-[n]3nccc3)c2F)N=C(c2ccn[n]2C2=CC=CCC2)C1=C FGMDUUOMAJWHGW-UHFFFAOYSA-N 0.000 description 1
- KWDQRBQEOQARPF-UHFFFAOYSA-N COC1=CN(c(ccc(N(C2)CC2F)c2)c2F)N=C(c2ccn[n]2-c2ccccc2)C1=O Chemical compound COC1=CN(c(ccc(N(C2)CC2F)c2)c2F)N=C(c2ccn[n]2-c2ccccc2)C1=O KWDQRBQEOQARPF-UHFFFAOYSA-N 0.000 description 1
- HKZJQRGMURJKHV-UHFFFAOYSA-N COC1=CN(c2cccc(C3CCOCC3)c2F)N=C(C2=CC=CCN2c2ccccc2)C1=O Chemical compound COC1=CN(c2cccc(C3CCOCC3)c2F)N=C(C2=CC=CCN2c2ccccc2)C1=O HKZJQRGMURJKHV-UHFFFAOYSA-N 0.000 description 1
- BWAPJIHJXDYDPW-UHFFFAOYSA-N Cc(cc(c(C)c1)N)c1N Chemical compound Cc(cc(c(C)c1)N)c1N BWAPJIHJXDYDPW-UHFFFAOYSA-N 0.000 description 1
- NJZXGWRQZVQOTR-UWCQTGLRSA-N Cc1ccccc1N/C(/C(C(/C=C\Nc1cccc(C(F)(F)F)c1)=O)=N)=C\C=N Chemical compound Cc1ccccc1N/C(/C(C(/C=C\Nc1cccc(C(F)(F)F)c1)=O)=N)=C\C=N NJZXGWRQZVQOTR-UWCQTGLRSA-N 0.000 description 1
- FVIOUDBDJPKVJV-XPOPEFDLSA-N NNC(C(C(/C=C\Nc1cccc(C(F)(F)F)c1)=O)=N)=O Chemical compound NNC(C(C(/C=C\Nc1cccc(C(F)(F)F)c1)=O)=N)=O FVIOUDBDJPKVJV-XPOPEFDLSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P25/22—Anxiolytics
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20220709P | 2009-02-05 | 2009-02-05 | |
| US61/202,207 | 2009-02-05 | ||
| US21392709P | 2009-07-30 | 2009-07-30 | |
| US61/213,927 | 2009-07-30 | ||
| PCT/US2010/000307 WO2010090737A1 (en) | 2009-02-05 | 2010-02-04 | Pyridazinone compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102365020A CN102365020A (zh) | 2012-02-29 |
| CN102365020B true CN102365020B (zh) | 2014-07-30 |
Family
ID=42398214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080014965.6A Active CN102365020B (zh) | 2009-02-05 | 2010-02-04 | 哒嗪酮化合物 |
Country Status (37)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009054791A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mglur5 |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| AU2010211050B2 (en) | 2009-02-05 | 2016-05-12 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds |
| WO2011163355A1 (en) | 2010-06-24 | 2011-12-29 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors |
| US20130116231A1 (en) * | 2010-07-12 | 2013-05-09 | Merck Sharp & Dohme Corp. | Tyrosine kinase inhibitors |
| US9029536B2 (en) | 2010-08-04 | 2015-05-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| EP2602255B1 (en) * | 2010-08-04 | 2017-04-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic ring compound |
| EP2602254B1 (en) | 2010-08-04 | 2017-06-14 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9150588B2 (en) | 2010-08-10 | 2015-10-06 | Takeda Pharmaceutical Company Limited | Substituted pyridazin-4(1H)-ones as phosphodiesterase 10A inhibitors |
| JP2013234123A (ja) * | 2010-09-03 | 2013-11-21 | Taisho Pharmaceutical Co Ltd | ３−ピラゾリル−２−ピリドン誘導体 |
| CA2827724A1 (en) | 2011-02-18 | 2012-08-23 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| WO2012124782A1 (ja) | 2011-03-16 | 2012-09-20 | 武田薬品工業株式会社 | 縮合複素環化合物 |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| EP2748158B1 (en) * | 2011-08-22 | 2018-01-24 | Takeda Pharmaceutical Company Limited | Radiolabeled compounds and their use as radiotracers for quantitative imaging of phosphodiesterase (pde10a) in mammals |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| AU2012337781B2 (en) | 2011-11-15 | 2017-07-06 | Takeda Pharmaceutical Company Limited | Dihydroxy aromatic heterocyclic compound |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| TW201444825A (zh) * | 2013-02-21 | 2014-12-01 | Takeda Pharmaceutical | 嗒□酮化合物的製造方法 |
| US9464076B2 (en) | 2013-03-15 | 2016-10-11 | Daiichi Sankyo Company, Limited | Benzothiophene derivative |
| US10039764B2 (en) | 2013-07-12 | 2018-08-07 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using PDE10A inhibitors and methods to measure PDE10A expression |
| SI3030549T1 (sl) * | 2013-09-12 | 2019-08-30 | Janssen Biopharma, Inc. | Spojine piridazinona in njihove uporabe |
| MX377396B (es) | 2013-09-12 | 2025-03-10 | Janssen Biopharma Inc | Compuestos de azapiridona y usos de los mismos. |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| ES2544869B2 (es) * | 2014-03-04 | 2016-01-18 | Universidade De Vigo | Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa |
| CN106232144B (zh) * | 2014-03-18 | 2019-12-06 | 武田药品工业株式会社 | 固体分散体 |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| US10208045B2 (en) | 2015-03-11 | 2019-02-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
| WO2016191935A1 (en) | 2015-05-29 | 2016-12-08 | Merck Sharp & Dohme Corp. | 6-alkyl dihydropyrazolopyrimidinone compounds as pde2 inhibitors |
| CA3006683A1 (en) | 2015-12-22 | 2017-06-29 | Jiangsu Hengrui Medicine Co., Ltd. | Benzopiperidine derivative, preparation method thereof and medical use thereof |
| US10736894B2 (en) | 2018-02-15 | 2020-08-11 | Ovid Therapeutics Inc. | Methods of treating developmental syndromes with PDE10A inhibitors |
| CN108498868B (zh) * | 2018-04-03 | 2020-09-15 | 北京大学口腔医学院 | 具有细胞外基质电学拓扑特征的带电复合膜及其制备方法 |
| CN110407806B (zh) * | 2018-04-28 | 2021-08-17 | 深圳微芯生物科技股份有限公司 | 甲酰胺类化合物、其制备方法及其应用 |
| WO2019241787A1 (en) * | 2018-06-15 | 2019-12-19 | The Regents Of The University Of Colorado A Body Corporate | Novel cyclic gmp-amp synthase (cgas) inhibitors and their method of use |
| EP3856185A1 (en) * | 2018-09-28 | 2021-08-04 | Takeda Pharmaceutical Company Limited | Balipodect for treating or preventing autism spectrum disorders |
| MX2019008440A (es) | 2019-07-15 | 2021-01-18 | Dva Farma Mexicana S A De C V | Composiciones de recubrimientos en pelicula para tabletas con brillantez incrementada, procedimiento de preparacion y aplicacion. |
| EP3805206A1 (en) * | 2019-10-08 | 2021-04-14 | Novaled GmbH | Compound and an organic semiconducting layer, an organic electronic device, a display device and a lighting device comprising the same |
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