CN102361859A - 用作Raf激酶抑制剂的杂芳基化合物 - Google Patents

用作Raf激酶抑制剂的杂芳基化合物 Download PDF

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Publication number
CN102361859A
CN102361859A CN2009801577085A CN200980157708A CN102361859A CN 102361859 A CN102361859 A CN 102361859A CN 2009801577085 A CN2009801577085 A CN 2009801577085A CN 200980157708 A CN200980157708 A CN 200980157708A CN 102361859 A CN102361859 A CN 102361859A
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China
Prior art keywords
ring
compound
nitrogen
optionally substituted
sulfur
Prior art date
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Pending
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CN2009801577085A
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English (en)
Chinese (zh)
Inventor
C.查奎
J.科斯罗
J.多林
关冰
M.霍曼
A.伊什钱科
J.H.琼斯
L.卡比格廷
G.库马拉韦尔
彭海若
N.鲍威尔
B.雷芒多
田中弘子
K.范夫洛滕
J.维塞尔斯
辛智利
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Biogen Inc
Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
Biogen Idec Inc
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Application filed by Millennium Pharmaceuticals Inc, Biogen Idec Inc filed Critical Millennium Pharmaceuticals Inc
Publication of CN102361859A publication Critical patent/CN102361859A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN2009801577085A 2008-12-30 2009-12-30 用作Raf激酶抑制剂的杂芳基化合物 Pending CN102361859A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14156108P 2008-12-30 2008-12-30
US61/141,561 2008-12-30
PCT/US2009/069795 WO2010078408A1 (en) 2008-12-30 2009-12-30 Heteroaryl compounds useful as raf kinase inhibitors

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CN102361859A true CN102361859A (zh) 2012-02-22

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US (1) US20120040951A1 (https=)
EP (1) EP2379513A1 (https=)
JP (1) JP2012514044A (https=)
CN (1) CN102361859A (https=)
AU (1) AU2009334997A1 (https=)
CA (1) CA2748274A1 (https=)
IL (1) IL213601A0 (https=)
MX (1) MX2011006997A (https=)
WO (1) WO2010078408A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102924446A (zh) * 2011-08-11 2013-02-13 上海吉铠医药科技有限公司 Pim激酶抑制剂及其制备方法与在制药中的应用
CN105384738A (zh) * 2014-08-21 2016-03-09 上海科州药物研发有限公司 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
CN106029072A (zh) * 2013-08-28 2016-10-12 麦迪韦逊技术股份有限公司 杂环化合物和使用方法
CN117143095A (zh) * 2023-08-03 2023-12-01 苏州汉德创宏生化科技有限公司 一种6-溴吡唑并[1,5-a]吡啶-3-羧酸及其制备方法
CN117567388A (zh) * 2023-11-14 2024-02-20 济南悟通生物科技有限公司 一种2-乙酰基-5-噻唑甲酸的合成方法
CN119241529A (zh) * 2024-09-20 2025-01-03 武汉九州钰民医药科技有限公司 一种Tovorafenib的制备方法
CN119241530A (zh) * 2024-09-20 2025-01-03 武汉九州钰民医药科技有限公司 一种Tovorafenib的药物合成工艺

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AR067354A1 (es) 2007-06-29 2009-10-07 Sunesis Pharmaceuticals Inc Compuestos utiles como inhibidores de la raf quinasa
EP2167497A2 (en) 2007-06-29 2010-03-31 Sunesis Pharmaceuticals, Inc. Heterocyclic compounds useful as raf kinase inhibitors
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
CN102574833B (zh) * 2009-10-12 2014-08-20 拜尔农作物科学股份公司 用作杀虫剂的酰胺和硫代酰胺
US9290485B2 (en) 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
EP2627324A4 (en) * 2010-10-11 2014-05-07 Univ Leland Stanford Junior SUBSTITUTED BENZAMIDES AND USES THEREOF
CN102250065B (zh) * 2011-05-20 2015-05-13 浙江海正药业股份有限公司 取代的三嗪苯脲衍生物及其用途
WO2012166463A2 (en) * 2011-05-27 2012-12-06 Neosome Life Sciences, LLC Aminooxazole inhibitors of cyclin dependent kinases
US9452995B2 (en) 2011-08-11 2016-09-27 Jikai Biosciences, Inc. Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9453003B2 (en) 2011-08-11 2016-09-27 Jikai Biosciences, Inc. Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9458151B2 (en) 2011-08-11 2016-10-04 Jikai Biosciences, Inc. Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
US9296732B2 (en) 2012-04-12 2016-03-29 The Board Of Trustees Of The Leland Stanford Junior University Substituted benzamides and their uses
IN2015DN00659A (https=) * 2012-08-07 2015-06-26 Janssen Pharmaceutica Nv
GB201401886D0 (en) 2014-02-04 2014-03-19 Lytix Biopharma As Neurodegenerative therapies
UY36294A (es) * 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
WO2016087363A1 (de) 2014-12-02 2016-06-09 Bayer Cropscience Aktiengesellschaft Bicyclische verbindungen als schädlingsbekämpfungsmittel
UA125171C2 (uk) 2015-07-02 2022-01-26 Янссен Саєнсиз Айрленд Юсі Антибактеріальні сполуки
CA3002416C (en) 2015-10-23 2023-10-24 Vifor (International) Ag Benzimidazolyl derivatives for use as ferroportin inhibitors
EA039916B1 (ru) * 2015-10-23 2022-03-28 Вифор (Интернациональ) Аг Новые ингибиторы ферропортина
JP2019518046A (ja) 2016-06-16 2019-06-27 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌薬としての複素環式化合物
JP7341060B2 (ja) 2017-02-10 2023-09-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Ｍａｐｋ経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物
KR20190121315A (ko) 2017-03-01 2019-10-25 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 병용 요법
US11124509B2 (en) 2017-03-23 2021-09-21 Clavius Pharmaceuticals, LLC. Tri-substituted imidazoles for the inhibition of TGF beta and methods of treatment
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
EP3732285A1 (en) 2017-12-28 2020-11-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
US12077548B2 (en) 2018-08-22 2024-09-03 Clavius Pharmaceuticals, LLC. Substituted imidazoles for the inhibition of TGF-β and methods of treatment
US10927111B2 (en) 2019-05-03 2021-02-23 Kinnate Biopharma Inc. Inhibitors of RAF kinases
BR112022007612A2 (pt) 2019-10-24 2022-09-20 Kinnate Biopharma Inc Inibidores de raf quinases
US11407737B2 (en) 2020-09-18 2022-08-09 Kinnate Biopharma Inc. Inhibitors of RAF kinases
WO2022081469A1 (en) 2020-10-12 2022-04-21 Kinnate Biopharma Inc. Inhibitors of raf kinases
CN112535793B (zh) * 2020-11-19 2021-10-08 融冲(深圳)生物医疗科技有限责任公司 药物涂层球囊导管的制备方法与应用
CN117561057A (zh) 2021-04-23 2024-02-13 金耐特生物制药公司 用raf抑制剂治疗癌症

Citations (5)

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EP0847992A1 (en) * 1996-09-30 1998-06-17 Mitsui Chemicals, Inc. Benzamide derivatives, useful as cell differentiation inducers
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