CN102335280B - Chinese medicinal buccal tablets for benign thyroid tumour postoperation consolidation therapy - Google Patents
Chinese medicinal buccal tablets for benign thyroid tumour postoperation consolidation therapy Download PDFInfo
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Abstract
The invention discloses Chinese medicinal buccal tablets for benign thyroid tumour postoperation consolidation therapy. The Chinese medicinal buccal tablets are characterized by being prepared from the following Chinese herbal materials in percentage by weight: 23 to 26 percent of figwort root, 12 to 15 parts of oyster, 10 to 12 percent of fineleaf schizonepeta herb, 10 to 12 percent of seaweed, 12 to 15 percent of divaricate saposhnikovia root, 15 to 17 percent of liquorice and 9 to 12 percent of physalis alkekengi. After being treated by operation, benign thyroid tumour is subjected to consolidation therapy by the Chinese medicinal buccal tablets for benign thyroid tumour postoperation consolidation therapy; and advantages that benign thyroid tumour can be treated by operation quickly are fully exerted, defects of high relapse rate after operation are overcome, and benign thyroid tumour is radically treated. The Chinese medicinal buccal tablets can be widely applied to treatment of benign thyroid tumour by combination of Chinese traditional and western medicine.
Description
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of benign thyroid tumor of the combination of Chinese and Western medicine, the Traditional Chinese medicine lozenge of specifically a kind of benign thyroid tumor postoperative after treatment.
Background technology
Thyroid tumor also are goiter on the traditional Chinese medical science, be a kind of commonly encountered diseases, and are particularly higher at the iodine deficient area sickness rate.In the old society of China, because science is undeveloped, thyroid tumor are very common, and after liberation, people begin the edible allusion quotation salt of science, the thyroid tumor sickness rate is greatly reduced, but still happen occasionally.Its pathogeny, the traditional Chinese medical science think due to the turbid harmony knot of foul smell, blood stasis, expectorant, and, diet uncomfortable with feelings will, body constitution have certain relation, and the ratio that clinical middle women gets thyroid tumor is higher than the male.Thyroid tumor comprise thyroid nodule, simple goiter, nodular goiter, thyroid cyst, thyroid adenoma etc., are benign thyroid tumor.The clinical symptoms of benign thyroid tumor is: Adam's apple both sides, throat can observe maybe and can touch swollen thing, and matter is harder, is difficult for moving, and can move up and down with swallowing act, and without tenderness or constriction, body of the tongue is redder or dark red, the little Huang of thin fur, the profound cunning of arteries and veins or thready pulse.Thyroid is the endocrine organ that body weight for humans is wanted, its thyroxine participates in growth, growth and the metabolism of human body, so generally do not advocate first operative treatment for the patients with thyroid neoplasm that the tumor body is less, adopt first conservative medication, generally be to adopt thyroxine sheet or thiamazole treatment, but adopt this two kinds of medicine treatments, cardiac function is had infringement, and very difficult thorough treatment.Large for the tumor body and have obvious disease patients with thyroid neoplasm, doctor trained in Western medicine thinks that operative treatment remains preferred plan.But clinical experience proves: very easily recurrence behind the patients with thyroid neoplasm operative treatment, and clinical data shows, and relapse rate can reach 65%, and the single operative treatment of this explanation is difficult to make patients with thyroid neoplasm to be effected a radical cure.In order to solve the problem that recurs behind the patients with thyroid neoplasm operative treatment, the method that adopts at present is to take " Euthyrox " to the patient." Euthyrox " is levothyrocine, belongs to endocrine preparation, though inhibition is arranged, if long-term taking in a large number can produce the side effect such as nervous, insomnia, agitation, hyperhidrosis, bulimia.For the diagnosis of benign thyroid tumor, according to clinical disease, and generally be not difficult to make a definite diagnosis through ultrasound diagnosis and magnetic resonance examination, cooperate again cytolgical examination, can not produce mistaken diagnosis.At present, the Chinese medicine for the treatment of thyroid tumor has multiple, mainly take the soft junction detoxifcation of reducing phlegm, clearing away liver-fire are regulated the flow of vital energy, activating blood circulation to dissipate blood stasis and dredge the collateral, the nourishing kidney easing the affected liver that nourishes heart, tonifying the lung spleen-benefiting mind-tranquilizing, YIN nourishing and the production of body fluid promoting quench the thirst Chinese medicine as main double controlling, if but simple employing treatment by Chinese herbs, treatment time is long, and for having significantly swollen thing and the obvious patient of clinical disease, treatment time is longer, and effect is not remarkable yet, even can affect best occasion for the treatment.Through retrieval, have not yet to see after treatment behind the thyroid tumor operation, prevent the report of the Chinese medicine that recurs.
Summary of the invention
After the object of the present invention is to provide the operation of a kind of benign thyroid tumor, for the Traditional Chinese medicine lozenge of the benign thyroid tumor postoperative after treatment that prevents from recurring, carry out after treatment.
For reaching above purpose, the technical solution adopted in the present invention is: the Traditional Chinese medicine lozenge of this benign thyroid tumor postoperative after treatment is characterized in that: it is made by the raw material of Chinese medicine of following percentage by weight:
Radix Scrophulariae 23-26%; Concha Ostreae 12-15%; Herba Schizonepetae 10-12%; Sargassum 10-12%; Radix Saposhnikoviae 12-15%; Radix Glycyrrhizae 15-17%; Calyx seu fructus physalis 9-12%.
The present invention also implements by following measure: in clinical, through application attestation, its optimum ratio is:
Radix Scrophulariae 24%; Concha Ostreae 13%; Herba Schizonepetae 11%; Sargassum 11%; Radix Saposhnikoviae 14%; Radix Glycyrrhizae 16%; Calyx seu fructus physalis 11%.
Preparation of the present invention: take by weighing each raw material of Chinese medicine by above weight ratio; then pulverize respectively; cross 300 mesh sieves; become powdery, restir is even, makes first granular with spray-drying pelleting machine; be pressed into lamellar with rotary tablet machine again; adopt at last analyzer and the test of tablet friabilator around the tablet, every heavy 0.6g is pressed in after up-to-standard on the sealing plate for subsequent use.This production method is conventional production method.
Instructions of taking of the present invention: containing, 3-4 time on the one, each 4.
Clinical trial analysis:
One, source of data
From in January, 1999 to 2006 year December, outside Hospital of Traditional Chinese Medicine one, outer two sections, the 180 routine benign thyroid tumor patients that see and treat patients altogether, wherein the male has 67 examples, and the women has 133 examples, and the age is at 15-42 between year.The operative treatment of all being in hospital in the court.
Two, the diagnostic criteria of benign thyroid tumor
The diagnosis of benign thyroid tumor, the one, according to its clinical symptoms: can touch swollen thing at cervical region, matter is harder, is difficult for mobilely, can move up and down with swallowing act, and without tenderness or constriction, body of the tongue is redder or dark red, the little Huang of thin fur, the profound cunning of arteries and veins or thready pulse; The 2nd, the patient is all made ultrasound diagnosis and magnetic resonance examination, can be diagnosed as thyroid tumor; The 3rd, fine needle aspiration is carried out rill and learned inspection, and clear and definite histological type can be got rid of the malignant goiter tumor, also can do pathological analysis by postoperative, and is further clear and definite.
Three, instructions of taking
After benign thyroid tumor operation 3 months, begin oral, containing, every day 3-4 time, each 4, check once half a year.
Four, criterion of therapeutical effect
Produce effects: afterwards check in a year, without the recurrence symptom, and followed up a case by regular visits to 5 years, still without the recurrence symptom.
Invalid: afterwards check in a year checks out the recurrence symptom.
Five, efficacy analysis
To above 180 patients with thyroid neoplasms of making a definite diagnosis, be divided into two groups, group 100 examples on probation all at first adopt operative treatment, perform the operations after 3 months, and containing tablet of the present invention, and instrucion containing every day 3-4 time, after 1 year, come the court to check by each 4.Matched group 80 examples only adopt operative treatment, afterwards institute's check in a year.The result is: in group 100 examples on probation, during check after 1 year, only finding has 1 example that the recurrence symptom is arranged, and obvious effective rate is 99%, to 1 routine patient of recurrence symptom is arranged, continue containing Traditional Chinese medicine lozenge of the present invention, after 2 years, the recurrence transference cure was followed up a case by regular visits to 5 years, did not all find the recurrence symptom; In 80 examples of matched group, only have 37 examples without the recurrence symptoms, obvious effective rate 46.3% has 43 examples the recurrence symptoms to occur, and relapse rate is 53.7%, to 43 examples of recurrence symptom occurring, and also containing Traditional Chinese medicine lozenge of the present invention afterwards, containing recurred symptom and also disappears after 1 year.
Adopt the present invention, for the less benign thyroid tumor patient of thyroid tumors, in the situation that do not adopt operative treatment, also try out, its curative effect is also more obvious, and just treatment time is slightly long.Because emphasis of the present invention is the treatment that solves postoperative recurrence, so, do not describe for the case for the treatment of thyroid tumor with the present invention merely.
Six, pharmacology analysis
Radix Scrophulariae: sweet, bitter, salty, be slightly cold.Return lung, kidney, stomach warp.Has removing heat from blood, nourishing YIN to lower pathogenic fire, detoxifcation, the effect of the kidney invigorating gas.Cure mainly the warm febrile disease blood of joining the army, fever of the body, excessive thirst, tongue falls, and sends out speckle, the hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency is insomnia, and constipation is hindered in Tianjin, and order is puckery dim-sighted, laryngopharynx swelling and pain, scrofula productive cough, skin sore.
Concha Ostreae: salty, be slightly cold.Return liver, kidney channel.Have suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.Cure mainly vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter, abdominal mass mass in the abdomen, spontaneous sweating.
Herba Schizonepetae: hot, little hardship, tepor.Return lung, Liver Channel.Have and dispel the wind, induce sweat, rash, the effect of hemostasis.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle is spitted blood, and has blood in stool.
Sargassum: salty, cold.Return liver, kidney, stomach warp.Has the antiinflammatory softening the hard mass, the effect of diuretic detumescent.Cure mainly goiter, scrofula, hernia, beriberi edema.
Radix Saposhnikoviae: hot, sweet, tepor.Return bladder, lung, spleen channel.Has expelling pathogenic wind from the body surface, removing dampness to relieve pain, the effect that relieving convulsion is antipruritic.Cure mainly affection of exogenous wind-cold, migraine and general headache, rheumatic arthralgia, stomachache is had loose bowels, discharging fresh blood stool, tetanus, the rubella pruritus, skin infection from the beginning of.
Radix Glycyrrhizae: sweet, flat.GUIXIN, spleen, stomach warp.Have and middle emergency lung moistening, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation.
Calyx seu fructus physalis: sour, bitter, cold.Return lung, spleen channel.Has relieving sore-throat by clearing away heat, tonneau two effect just.Cure mainly laryngopharynx swelling and pain, the cough due to lung-heat, jaundice, dysentery, edema, urine leaching is puckery, constipation, impetigo, eczema, erysipelas.
The present invention is take Calyx seu fructus physalis as monarch drug, take Radix Scrophulariae, Concha Ostreae, Sargassum as ministerial drug, assistant is with Herba Schizonepetae, Radix Saposhnikoviae, collection consumer edema, hard masses softening and resolving, heat-clearing and toxic substances removing, antiinflammatory softening the hard mass, ataralgesia, conditioning endocrine, blood circulation promoting competent silt, enhancing are immune to a side, both lay particular emphasis on the strong body of postoperative tonification, laid particular emphasis on again control recurrence knot.All medicines match and play altogether the after treatment of benign thyroid tumor postoperative, have obtained positive effect.
Beneficial effect of the present invention is: compare with employing operative treatment or treatment by Chinese herbs method that present benign thyroid tumor is simple, both given full play to fast advantage of operative treatment, overcome again the high deficiency of Postoperative recurrent rate, made benign thyroid tumor obtain radical cure.
The specific embodiment
Embodiment 1
Press following each raw material of Chinese medicine of percentage by weight weighing:
Radix Scrophulariae 24%; Concha Ostreae 13%; Herba Schizonepetae 11%; Sargassum 11%; Radix Saposhnikoviae 14%; Radix Glycyrrhizae 16%; Calyx seu fructus physalis 11%.
Once produce what of Chinese medicine sheet, press the several 10 days consumption of clinical case and prepare.Again preparation after being finished.And pulverize respectively; cross 300 mesh sieves; become powdery; restir is even, makes first granularly with spray-drying pelleting machine, is pressed into lamellar with rotary tablet machine again; adopt at last tablet all around analyzer and the test of tablet friabilator; every heavy 0.6g is pressed in after up-to-standard on the sealing plate for subsequent usely, namely becomes the Traditional Chinese medicine lozenge of benign thyroid tumor postoperative after treatment.
Adopt the present embodiment, treat altogether 40 routine benign thyroid tumor patients, its therapeutic scheme is to perform the operation first, begin the Traditional Chinese medicine lozenge of this benign thyroid tumor postoperative after treatment of containing after 3 months, and enjoin containing 3 times every day, each 4, after 1 year, come the court's check, the check content comprises inquiring, inspection, ultrasound diagnosis, magnetic resonance examination.From 1 year review result, have no recurrent cases, followed up a case by regular visits to 5 years, be showed no recurrent cases.
Model case:
Chen Junfang, woman, 28 years old, laid-off worker.Come the court medical on May 19th, 2000, on inspection: the left and right side thyroid all has lump, and inspection can obviously be found out; Through touching, be circle, the with no pressure pain, matter is harder, is difficult for moving, and can move up and down with swallowing act, illustrates that lump length is on thyroid; Dimly red tongue, the little Huang of thin fur, the profound cunning of arteries and veins; Ultrasound diagnosis and magnetic resonance examination, swollen thing are 5*4cm, smooth surface.Be defined as benign thyroid tumor on May 21st, 2000, and carry out resection operation.The Traditional Chinese medicine lozenge that begins this benign thyroid tumor postoperative after treatment of containing on August 21st, 2000, early, middle and late three times of natural gift, containing after meal, one time 4.Afterwards check in 1 year has no the recurrence symptom, follows up a case by regular visits to 5 years, the recurrence symptom do not occur.
Embodiment 2
Press following each raw material of Chinese medicine of percentage by weight weighing:
Radix Scrophulariae 26%; Concha Ostreae 12%; Herba Schizonepetae 12%; Sargassum 10%; Radix Saposhnikoviae 15%; Radix Glycyrrhizae 15%; Calyx seu fructus physalis 10%.
Prepare the method for Traditional Chinese medicine lozenge with embodiment 1.
Adopt the present embodiment, treat altogether 30 routine benign thyroid tumor patients, its therapeutic scheme is to perform the operation first, begin the Traditional Chinese medicine lozenge of this benign thyroid tumor postoperative after treatment of containing after 3 months, and enjoin containing 4 times every day, each 4, after 1 year, come the court's check, the check content comprises inquiring, inspection, ultrasound diagnosis, magnetic resonance examination.From 1 year review result, have no recurrent cases, followed up a case by regular visits to 5 years, be showed no recurrent cases.
Model case:
Cai advances, man, 40 years old, Zhai Li people from town, Laiwu City Laicheng district.Come the court medical on November 1st, 2005.Readme was subjected to setback mentally in the time of 25 years old, just feel in the time of 30 years old that the right side cervical region sends out slightly, and oneself also can touch lump, and by taking medicine, have an injection, but effect is little in the commune hospital, town.On inspection: right thyroid has the large lump of Semen Juglandis; Through touching, be ellipse, the with no pressure pain, matter is harder, can move up and down with swallowing act; Dimly red tongue, the little Huang of thin fur, arteries and veins is profound thin; Ultrasound diagnosis and magnetic resonance examination, swollen thing are 3*5cm, smooth surface.Be defined as benign thyroid tumor on November 2nd, 2005, and carry out resection operation.The Traditional Chinese medicine lozenge that begins this benign thyroid tumor postoperative after treatment of containing on February 2nd, 2006, early, middle and late three times of natural gift, containing after meal, one time 4.Afterwards check in 1 year has no the recurrence symptom, follows up a case by regular visits to 5 years, the recurrence symptom do not occur.
Embodiment 3
Press following each raw material of Chinese medicine of percentage by weight weighing:
Radix Scrophulariae 23%; Concha Ostreae 15%; Herba Schizonepetae 10%; Sargassum 12%; Radix Saposhnikoviae 12%; Radix Glycyrrhizae 17%; Calyx seu fructus physalis 11%.
Prepare the method for Traditional Chinese medicine lozenge with embodiment 1.
Adopt the present embodiment, treat altogether 30 routine benign thyroid tumor patients, its therapeutic scheme is to perform the operation first, begin the Traditional Chinese medicine lozenge of this benign thyroid tumor postoperative after treatment of containing after 3 months, and enjoin containing 3 times every day, each 4, after 1 year, come the court's check, the check content comprises inquiring, inspection, ultrasound diagnosis, magnetic resonance examination.From 1 year review result, 1 example is arranged, after the excision of left and right side thyroid tumor, recur again tuberosity in thyroid position, left side, remaining is showed no the recurrence symptom, still adopts the present invention to treat to this 1 example, check after another year, the recurrence transference cure through following up a case by regular visits to, has no again recurrence.
Model case:
Li Tingting, woman, 29 years old, Xiaoyi people from town, Laiwu City Laicheng district.Came the court medical on the 10th in JIUYUE in 2006.Readme after bearing child in 25 years old, was subjected to strike mentally, just felt in the time of 27 years old that the left and right side cervical region has swollen thing.On inspection: the left side thyroid has the large lump of Semen Juglandis, and right thyroid has the large lump of acorn nut; Through touching, the with no pressure pain can move up and down with swallowing act; Red tongue, the little Huang of thin fur, arteries and veins is profound thin; Ultrasound diagnosis and magnetic resonance examination, the swollen thing in left side is 3*4cm, the swollen thing in right side is 1*2cm, smooth surface.Carried out resection operation on the 12nd in JIUYUE in 2006.In the Traditional Chinese medicine lozenge that December in 2006 began this benign thyroid tumor postoperative after treatment of containing on the 12nd, early, middle and late three times of natural gift, containing after meal, one time 4.Afterwards check in 1 year has no the recurrence symptom, follows up a case by regular visits to 5 years, the recurrence symptom do not occur.
Claims (1)
1. the Traditional Chinese medicine lozenge of benign thyroid tumor postoperative after treatment, it is characterized in that: it is made by the raw material of Chinese medicine of following percentage by weight: Radix Scrophulariae 23-26%; Concha Ostreae 12-15%; Herba Schizonepetae 10-12%; Sargassum 10-12%; Radix Saposhnikoviae 12-15%; Radix Glycyrrhizae 15-17%; Calyx seu fructus physalis 9-12%.
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| CN103432308A (en) * | 2013-08-17 | 2013-12-11 | 广州市云桥生物科技有限公司 | Composition consisting of effective traditional Chinese medicine parts and used for treating benign thyroid tumor |
| CN105381445A (en) * | 2015-12-26 | 2016-03-09 | 青岛昌安达药业有限公司 | Traditional Chinese medicine composition used for treating thyroid tumors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1422642A (en) * | 2001-12-04 | 2003-06-11 | 何文法 | Series Chinese medicinal composition for treating tumor |
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| CN1422642A (en) * | 2001-12-04 | 2003-06-11 | 何文法 | Series Chinese medicinal composition for treating tumor |
Non-Patent Citations (4)
| Title |
|---|
| 亚急性甲状腺炎中医药治疗概况;石磊等;《新中医》;20010831;第33卷(第08期);第69页第1栏第2段 * |
| 向丽萍等.瘿瘤丸治疗甲状腺腺瘤的临床观察.《湖南中医学院学报》.2001,第21卷(第01期), |
| 瘿瘤丸治疗甲状腺腺瘤的临床观察;向丽萍等;《湖南中医学院学报》;20010331;第21卷(第01期);33-34 * |
| 石磊等.亚急性甲状腺炎中医药治疗概况.《新中医》.2001,第33卷(第08期), |
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