CN104352990A - Pharmaceutical composition for treating thyroid cancer - Google Patents

Pharmaceutical composition for treating thyroid cancer Download PDF

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Publication number
CN104352990A
CN104352990A CN201410677269.3A CN201410677269A CN104352990A CN 104352990 A CN104352990 A CN 104352990A CN 201410677269 A CN201410677269 A CN 201410677269A CN 104352990 A CN104352990 A CN 104352990A
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effects
pharmaceutical composition
thyroid cancer
rhizoma
usnea
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刘健楠
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    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/902Sparganiaceae (Bur-reed family)

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Abstract

The invention relates to a pharmaceutical composition for treating thyroid cancer. The pharmaceutical composition for treating the thyroid cancer is prepared from the following traditional Chinese medicine raw materials in weight ratio: 3-8g of cladosiphon okamuranus, 3-5g of bryozoatum, 5-8g of concha arcae, 5-10g of peperomia dindygulensis miq, 5-8g of curcuma zedoary, 3-8g of sparganium stenophyllum, 3-5g of polygonatum kingianum, 3-5g of trollius chinensis bunge, 3-9g of sonchus brachyotus, 3-5g of Chinese usnea, 2-5g of roughhaired holly root, 2-6g of evodia lepta, 3-6g of marsdenia tenacissima, 5-8g of magnet and 5-8g of platycladi seed. Cladosiphon okamuranus, bryozoatum and concha arcae have the effects of softening hard mass and eliminating goiter, peperomia dindygulensis miq, curcuma zedoary, sparganium stenophyllum and roughhaired holly root have the effects of removing blood stasis and eliminating stagnation, polygonatum kingianum, magnet and platycladi seed have the effects of nourishing the heart and the kidneys, trollius chinensis bunge, sonchus brachyotus, Chinese usnea, evodia lepta and marsdenia tenacissima have the effects of clearing heat and detoxifying, effects of all the raw materials are mutually synergistic, the curative effect on the thyroid cancer is obvious, the effective rate is high, pain of a patient is alleviated, and the life of a patient is prolonged.

Description

A kind of pharmaceutical composition for the treatment of thyroid carcinoma
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of thyroid carcinoma.
Background technology
Thyroid carcinoma is modal thyroid malignancy, accounts for 1% of whole body malignant tumor.Except medullary carcinoma, most thyroid carcinoma originates from follicular epithelial cells.Early clinical manifestation is not obvious, many no conscious symptons, and neck region lump is often asymmetry lump.Lump easily comparatively early produces pressure symptom, and as with hoarseness, hypopnea, dysphagia, or the pressure symptom such as local tenderness, during jugular vein pressurized, can occur the signs such as Ipsilateral venous engorgement and facial edema.
Because anaplastic thyroid carcinoma grade malignancy is high, PD is very fast, easy organ-tissue around of invading is as the nerve of trachea, esophagus, cervical region and blood vessel, therefore, late period when often going to a doctor, cannot excision, can only row fluconazole ear drops and chemotherapy, only at tracheal compression or tracheotomy excision or tracheotomy when blocking.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of thyroid carcinoma, evident in efficacy, effective percentage is high, extends patient vitals.
The technical solution adopted for the present invention to solve the technical problems is: a kind of pharmaceutical composition for the treatment of thyroid carcinoma, is made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 3-8g, Pumex 3-5g, Concha Arcae 5-8g, Herba Peperomiae Dindygulensis 5-10g, Rhizoma Curcumae 5-8g, rhizoma scirpi 3-8g, Rhizoma Polygonati 3-5g, Flos Trollii 3-5g, Herba Sonchi Arvensis 3-9g, Usnea 3-5g, Radix Ilicis Asprellae 2-5g, Foliumet Ramulus Evodiae 2-6g, Caulis Marsdeniae Tenacissimae 3-6g, Magnetitum 5-8g, Semen Platycladi 5-8g.
Preferably, the pharmaceutical composition for the treatment of thyroid carcinoma, is made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 5g, Pumex 3g, Concha Arcae 5g, Herba Peperomiae Dindygulensis 8g, Rhizoma Curcumae 6g, rhizoma scirpi 5g, Rhizoma Polygonati 5g, Flos Trollii 3g, Herba Sonchi Arvensis 5g, Usnea 4g, Radix Ilicis Asprellae 3g, Foliumet Ramulus Evodiae 5g, Caulis Marsdeniae Tenacissimae 4g, Magnetitum 6g, Semen Platycladi 5g.
The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:
Nemacystus decipiens (Sur.) Kuck is the frond of Nemacystus decipiens (Sur.) Kuck section plant Nemacystus decipiens (Sur.) Kuck, salty, cold, returns liver, lung meridian, eliminating phlegm and softening indurated mass; Inducing diuresis to remove edema.Main goiter; Goiter; Laryngitis; Bronchitis.
Pumex is the block of igneous rock rock Pumex or the skeleton of hilum section animal costazia aculeata Canu et Bassler, costazia costazii Audouin etc., salty, cold, returns lung, kidney channel, removing heat from the lung and dissipating phlegm, hard masses softening and resolving.For cough due to lung-heat, yellowish thick sputum, spitting of blood, bronchitis, tuberculous lymphadenitis.
Concha Arcae is the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa or Scapharca subcrenata, salty, flat, returns lung, stomach, Liver Channel, expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, stomachache pantothenic acid.
Herba Peperomiae Dindygulensis is the herb of Piperaceae plant Herba Peperomiae Dindygulensis, pungent, cool, returns lung, spleen, liver, kidney channel, heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Inducing diuresis to remove edema.Main lung-heat cough with asthma; Measles; Sore; Cancerous protuberance; Burn and scald; Traumatic injury; Oedema due to nephritis." choosing of Yunnan Chinese herbal medicine ": " eliminating stasis and resolving masses, anticancer.Control gastric cancer, esophageal carcinoma, hepatocarcinoma, breast carcinoma, pulmonary carcinoma.″
Rhizoma Curcumae is the rhizome of zingiberaceous plant Rhizoma Curcumae, pungent, bitter, and temperature, returns liver, spleen channel, circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.There is the effect of directly killing oncocyte, for various cancer.
Rhizoma scirpi is the dry tuber of Sparganiaceae plant rhizoma scirpi, acrid in the mouth, bitter, and property is put down, and return liver, spleen channel, blood stasis dispelling stimulates the menstrual flow; Removing blood stasis eliminating mass; Circulation of qi promoting removing food stagnancy.Main amenorrhea due to stagnation of blood; Dysmenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury congestive edema; Enclosed mass in abdomen; Abdominal pain due to retention of food.
Rhizoma Polygonati is the rhizome of liliaceous plant Rhizoma Polygonati, P. cyrtonema, hot river Rhizoma Polygonati, P. kingianum, polygonatum cirrhifolium Royle etc., sweet, flat, returns spleen, lung, kidney channel, boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Flos Trollii is the flower of ranunculaceae plant Flos Trollii or Asia Flos Trollii, bitter in the mouth, and cold nature, attaches to the lung and stomach meridians, heat-clearing and toxic substances removing; Detumescence; Improving eyesight.Cure mainly cold, fever; Laryngopharynx swelling and pain; Aphtha; Gingival swelling and pain; Gingival hemorrhage; Conjunctival congestion and swelling pain; Furuncle swelling toxin; Acute myringitis; Acute lymphangitis.
Herba Sonchi Arvensis is the herb of feverfew Herba Sonchi Arvensis, and bitter in the mouth is cold in nature, heat-clearing and toxic substances removing; Promoting diuresis and pus discharge; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Furuncle toxic swelling; Hemorrhoid; Acute bacillary dysentery; Intestinal is scorching; Lung abscess; Acute appendicitis; Leaf blood; Epistaxis ' spitting of blood; Hematuria; Have blood in stool; Metrorrhagia.
Usnea, be the filamentous of Usneaceae plant Usnea Longissima, broken stem Usnea, sweet, flat, GUIXIN, kidney, lung meridian, liver heat removing, reduces phlegm, hemostasis, removing toxic substances.Control headache, conjunctival congestion, cough with copious phlegm, malaria, scrofula, leucorrhea, metrorrhagia, traumatic hemorrhage, carbuncle, venom." property of medicine opinion ": " control cold and heat, tell objective sputum in the heart, skin ulcer of decaptitating, tumor wart in major event.″
Radix Ilicis Asprellae is the root of holly plant Folium Mume Ilicis Purpureae, bitter, sweet, cold, returns lung, liver, large intestine channel, heat clearing away; Promote the production of body fluid; Dissipating blood stasis; Removing toxic substances.Main flu; Headache; Dizzy; Calentura excessive thirst; Eruptive disease; Diarrhea of heat type; Lung abscess; Pertussis; Laryngopharynx swelling and pain; Hemorrhoidal bleeding; Gonorrhea; Furuncle swelling toxin; Traumatic injury.
Foliumet Ramulus Evodiae, Rutaceae Evodia plant Foliumet Ramulus Evodiae is used as medicine with root and leaf, bitter, cold, heat-clearing and toxic substances removing, eliminating stasis to stop pain.Prevent and treat influenza, epidemic cerebrospinal meningitis, encephalitis B, heatstroke, cure cold high heat, tonsillitis, pharyngolaryngitis, lung abscess, pneumonia, malaria, rheumatic arthritis, sciatica, lumbago and skelalgia, stomachache, icterohepatitis.
Caulis Marsdeniae Tenacissimae is the rattan of asclepiadaceae plant Caulis Marsdeniae Tenacissimae, root or leaf, bitter, cold, relieving cough and asthma, and lactogenesis diuresis is anticancer.For upper respiratory tract infection, bronchitis, bronchial asthma, galactostasis, dysuria, cancerous protuberance; Carbuncle furuncle infections is controlled in leaf external." choosing of Yunnan Chinese herbal medicine ": " antiinflammatory, cough-relieving are relievingd asthma, anticancer.Control bronchitis, bronchial asthma, various cancer, rheumatism, traumatic injury, fracture, optical fundus illness, gastropathy.″
Magnetitum is the Ore of oxide-based mineral magnetic iron ore, Xin Xian, flat, returns kidney, liver, lung meridian, suppressing the hyperactive liver and subsiding YANG; Calm the nerves relieving convulsion; Hearing-improing and eyesight improving; Helping inspiration to relieve asthma.Main dizzy; Order flower; Deaf; Tinnitus; Palpitation with fear; Insomnia, dyspnea of suffering from a deficiency of the kidney." not Lu ": support kidney and hide, bone strengthening gas, beneficial smart relieving restlessness, gets round by bribery, subduing inflammation scrofula, and neck core is had sore throat, pediatric epilepsy scared.
Semen Platycladi is the kernel of Cupressaceae plant Cacumen Platycladi, sweet, flat, GUIXIN, kidney, large intestine channel, tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
The present invention has following beneficial effect: Nemacystus decipiens (Sur.) Kuck, Pumex, Concha Arcae softening the hard mass disappear wart, Herba Peperomiae Dindygulensis, Rhizoma Curcumae, rhizoma scirpi, Radix Ilicis Asprellae eliminating stasis and resolving masses, Rhizoma Polygonati, Magnetitum, Semen Platycladi nourishing the heart and kidney, Flos Trollii, Herba Sonchi Arvensis, Usnea, Foliumet Ramulus Evodiae, Caulis Marsdeniae Tenacissimae heat-clearing and toxic substances removing, each raw material drug effect is worked in coordination with mutually, and evident in efficacy to thyroid carcinoma, effective percentage is high, alleviate patient suffering, extend patient vitals.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
The pharmaceutical composition for the treatment of thyroid carcinoma, is made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 3g, Pumex 4g, Concha Arcae 8g, Herba Peperomiae Dindygulensis 6g, Rhizoma Curcumae 8g, rhizoma scirpi 3g, Rhizoma Polygonati 4g, Flos Trollii 4g, Herba Sonchi Arvensis 7g, Usnea 5g, Radix Ilicis Asprellae 2g, Foliumet Ramulus Evodiae 6g, Caulis Marsdeniae Tenacissimae 3g, Magnetitum 8g, Semen Platycladi 6g.
Embodiment 2
The pharmaceutical composition for the treatment of thyroid carcinoma, is made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 5g, Pumex 3g, Concha Arcae 5g, Herba Peperomiae Dindygulensis 8g, Rhizoma Curcumae 6g, rhizoma scirpi 5g, Rhizoma Polygonati 5g, Flos Trollii 3g, Herba Sonchi Arvensis 5g, Usnea 4g, Radix Ilicis Asprellae 3g, Foliumet Ramulus Evodiae 5g, Caulis Marsdeniae Tenacissimae 4g, Magnetitum 6g, Semen Platycladi 5g.
Embodiment 3
The pharmaceutical composition for the treatment of thyroid carcinoma, is made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 8g, Pumex 3g, Concha Arcae 6g, Herba Peperomiae Dindygulensis 10g, Rhizoma Curcumae 5g, rhizoma scirpi 8g, Rhizoma Polygonati 4g, Flos Trollii 5g, Herba Sonchi Arvensis 3g, Usnea 4g, Radix Ilicis Asprellae 4g, Foliumet Ramulus Evodiae 2g, Caulis Marsdeniae Tenacissimae 6g, Magnetitum 5g, Semen Platycladi 8g.
Embodiment 4
The pharmaceutical composition for the treatment of thyroid carcinoma, is made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 6g, Pumex 5g, Concha Arcae 7g, Herba Peperomiae Dindygulensis 5g, Rhizoma Curcumae 7g, rhizoma scirpi 7g, Rhizoma Polygonati 3g, Flos Trollii 3g, Herba Sonchi Arvensis 9g, Usnea 3g, Radix Ilicis Asprellae 5g, Foliumet Ramulus Evodiae 4g, Caulis Marsdeniae Tenacissimae 5g, Magnetitum 7g, Semen Platycladi 7g.
Clinical data
Physical data: accept for medical treatment altogether thyroid cancer patients 120 example, wherein male 36 example, women 84 example, age 31-68 year, 56 years old mean age.
Therapeutic Method: pharmaceutical composition of the present invention is decocted in water for oral dose, every day potion, one day twice, sooner or later sub-service one month was a course for the treatment of.
Curative effect judging standard:
Cure: throat lump, clinical symptom disappearance, pathological biopsy cancer-free cell finds;
Effective: throat mass reduction, clinical symptom relief;
Invalid: throat lump does not reduce, and clinical symptoms is without improvement.
Therapeutic outcome: in 120 routine patients, cures 39 examples, effective 75 examples, invalid 6 examples, cure rate 32.5%, and total effective rate 95%, effective percentage is high, can suppress the tumor growth of thyroid carcinoma, thus extends the life of patient.
Model case 1
Beam so-and-so, female, 41 years old, is admitted to hospital because of " find cervical region swell thing 3 months " for 2011.Patient found right neck circle swollen thing during health check-up before 3 months, as thumb first size, without pain, with swallowing activity, show in my outer court's row neck ultrasonic inspection: right thyroid swells thing; Thyroid function checks: show no obvious abnormalities.For asking further diagnosis and treatment, now my Out-patient Department, takes in institute with " right thyroid swell thing ".Disease come spiritual can, diet, defecation are as usual, sleep can, in the recent period without obviously losing weight, be diagnosed as thyroid carcinoma on inspection.Obviously reduce with thing swollen after the course for the treatment of of medicine composite for curing of the present invention, after the course for the treatment of of continual cure, swollen thing disappears, and advises it to continue to strengthen treatment 10 doses recovery from illness.So far do not recur.
Model case 2
Zhu, man, 59 years old, in June, 2006 is diagnosed as thyroid carcinoma through local hospital, row excision, postoperatively recurs after radiotherapy repeatedly, disease is seen: throat goiter protuberantia quality is hard, and comparatively fixing, shape is as inflammatory blepharoedema, sometimes swell and have a pain, chest distress, cough with copious phlegm or both sides, throat scrofula are grown thickly, appetite stimulator, two is just uncomfortable, and body of the tongue is livid purple or have ecchymosis, thick and greasy fur, stringy and rolling pulse.Alleviate by symptom after the course for the treatment of of medicine composite for curing of the present invention, throat goiter deliquescing, diet increases, and two is just normal, and after two courses for the treatment of of continual cure, cancerous protuberance disappears, and clinical cure, follows up a case by regular visits to and be still still living and in good health so far.

Claims (2)

1. treat a pharmaceutical composition for thyroid carcinoma, it is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 3-8g, Pumex 3-5g, Concha Arcae 5-8g, Herba Peperomiae Dindygulensis 5-10g, Rhizoma Curcumae 5-8g, rhizoma scirpi 3-8g, Rhizoma Polygonati 3-5g, Flos Trollii 3-5g, Herba Sonchi Arvensis 3-9g, Usnea 3-5g, Radix Ilicis Asprellae 2-5g, Foliumet Ramulus Evodiae 2-6g, Caulis Marsdeniae Tenacissimae 3-6g, Magnetitum 5-8g, Semen Platycladi 5-8g.
2. the pharmaceutical composition for the treatment of thyroid carcinoma as claimed in claim 1, is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Nemacystus decipiens (Sur.) Kuck 5g, Pumex 3g, Concha Arcae 5g, Herba Peperomiae Dindygulensis 8g, Rhizoma Curcumae 6g, rhizoma scirpi 5g, Rhizoma Polygonati 5g, Flos Trollii 3g, Herba Sonchi Arvensis 5g, Usnea 4g, Radix Ilicis Asprellae 3g, Foliumet Ramulus Evodiae 5g, Caulis Marsdeniae Tenacissimae 4g, Magnetitum 6g, Semen Platycladi 5g.
CN201410677269.3A 2014-11-24 2014-11-24 Pharmaceutical composition for treating thyroid cancer Pending CN104352990A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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CN105853844A (en) * 2016-05-19 2016-08-17 李丽丽 Traditional Chinese medicine preparation taken by patients suffering from radiology thyroid cancer and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN105853754A (en) * 2016-05-19 2016-08-17 李丽丽 Traditional Chinese medicinal composition for treating thyroid cancer and preparation method thereof
CN105853844A (en) * 2016-05-19 2016-08-17 李丽丽 Traditional Chinese medicine preparation taken by patients suffering from radiology thyroid cancer and preparation method thereof

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Application publication date: 20150218