CN113082168A

CN113082168A - Pharmaceutical composition for treating lung cancer and application thereof

Info

Publication number: CN113082168A
Application number: CN202110337611.5A
Authority: CN
Inventors: 马宇振; 马医博; 邢盼盼; 马俊鹏; 马腾飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-03-30
Filing date: 2021-03-30
Publication date: 2021-07-09

Abstract

The invention belongs to a pharmaceutical composition for treating lung cancer and application thereof; comprises the following raw materials: american ginseng, radix bupleuri, flos Pruni mume, fructus Trichosanthis, Poria, stigma Maydis, colla Corii Asini, rhizoma Bletillae, Concha Ostreae, Concha Meretricis Seu Cyclinae and radix Platycodi; the invention mainly supplements middle-jiao energy, nourishes lung yin, regulates yin and yang of viscera through ascending and descending, assists in clearing heat, removing phlegm, relieving chest stuffiness, dissipating stagnation, moistening dryness, lubricating intestines, inducing diuresis, excreting dampness and blocking the source of phlegm generation, and supplements qi, regulates yin and yang of viscera and blocks the source of phlegm generation through the treatment rule so as to achieve the characteristics of treating both principal and secondary aspects of disease, obvious effect, difficult recurrence after healing and high cure rate.

Description

Pharmaceutical composition for treating lung cancer and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating lung cancer and application thereof.

Background

Lung cancer is a malignant tumor, cancer cells mainly originate from the mucosal epithelium of the bronchi, which is one of the most common malignant tumors worldwide, with cancer having a high incidence and the highest number of deaths; in the world, lung cancer deaths account for 28 percent of the total cancer deaths, and the lung cancer deaths are the first, and the 5-year survival rate of lung cancer patients is 15 percent at most. The current medical measures are difficult to diagnose the lung cancer at an early stage, and most patients have a middle-advanced stage when hospitalizing or making a definite diagnosis, which causes great difficulty in treating the lung cancer; the current common western medicine treatment modes are as follows: if the lung cancer is in the early stage and is not transferred, the method of removing the tumor by operation is generally adopted, and the comprehensive means of radiotherapy or synchronous radiotherapy and chemotherapy can be possibly adopted for treatment; if advanced, metastasis to a distant site is possible, by radiotherapy, chemotherapy, targeted therapy, immunotherapy, or even a combination of therapies. The method is helpful for prolonging the survival time of the patient, but has the defects of high treatment cost, high mental stress of the patient and family members, great suffering of the patient and easy relapse, and particularly the weak patient cannot bear the treatment scheme again after the relapse; based on the treatment, part of patients adopt traditional Chinese medicine to carry out conservative treatment; the traditional Chinese medicine considers that the traditional Chinese medicine belongs to the category of lung accumulation, the main causes of the attack are the imbalance of yin and yang of viscera, the weakness of lung and the insufficiency of lung qi, and on the basis, the stagnation is formed by long-term accumulation of phlegm, water dampness, qi stagnation, blood stasis and the like; based on the reasons, the traditional Chinese medicine generally adopts the treatment rules of promoting blood circulation, dredging collaterals, tonifying qi and nourishing yin; or adopts the treatment rules of supplementing qi and nourishing yin, clearing away heat and toxic material, reducing phlegm and resolving masses; or adopts the therapeutic principle of tonifying viscera and clearing heat and eliminating phlegm as the therapeutic principle; the problem of yin-yang disharmony of viscera can not be fundamentally solved through the above treatment rules, and the treatment effect of the traditional Chinese medicine is poor and not obvious because the root problem can not be solved; especially, the condition of traditional Chinese medicine is rapidly repeated after the traditional Chinese medicine is stopped, which causes the distrust of patients and family members to the traditional Chinese medicine.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide the pharmaceutical composition for treating the lung cancer, which is mainly used for tonifying middle-jiao energy, nourishing lung yin and regulating yin and yang of internal organs by ascending and descending, is assisted by clearing heat, removing phlegm, relieving chest stuffiness, eliminating stagnation, moistening dryness, lubricating intestines, promoting diuresis, excreting dampness and blocking the source of phlegm generation, and can be used for tonifying qi, regulating yin and yang of the internal organs and blocking the source of phlegm generation through the treatment rule so as to treat both symptoms and root causes, has obvious effect, is not easy to relapse after healing and has high cure rate, and the application thereof.

The purpose of the invention is realized as follows:

a pharmaceutical composition for treating lung cancer is prepared from the following raw materials: american ginseng, radix bupleuri, flos Pruni mume, fructus Trichosanthis, Poria, stigma Maydis, colla Corii Asini, rhizoma Bletillae, Concha Ostreae, Concha Meretricis Seu Cyclinae and radix Platycodi.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 15-90 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 3-15 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 15-30 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 3-6 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 4-6 parts of American ginseng, 5-9 parts of radix bupleuri, 3-4 parts of flos Pruni mume, 15-20 parts of trichosanthes kirilowii Maxim, 9-11 parts of poria cocos, 20-30 parts of corn stigma, 5-9 parts of donkey-hide gelatin, 5-6 parts of rhizoma bletillae, 9-18 parts of oyster, 9-15 parts of clam shell and 6-9 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: the traditional Chinese medicine composition comprises, by weight, 4 parts of American ginseng, 9 parts of radix bupleuri, 4 parts of flos Pruni mume, 19 parts of trichosanthes kirilowii Maxim, 11 parts of poria cocos, 20 parts of corn stigma, 6 parts of donkey-hide gelatin, 5 parts of rhizoma bletillae, 17 parts of oyster, 10 parts of clam shell and 7 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 60-90 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 6-15 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-5 parts of American ginseng, 3-6 parts of radix bupleuri, 4-5 parts of flos Pruni mume, 9-14 parts of trichosanthes kirilowii Maxim, 11-15 parts of poria cocos, 70-80 parts of corn stigma, 3-6 parts of donkey-hide gelatin, 8-12 parts of rhizoma bletillae, 19-30 parts of oyster, 6-8 parts of clam shell and 3-5 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 5 parts of American ginseng, 4 parts of radix bupleuri, 5 parts of flos Pruni mume, 10 parts of trichosanthes kirilowii Maxim, 15 parts of poria cocos, 75 parts of corn stigma, 3 parts of donkey-hide gelatin, 12 parts of rhizoma bletillae, 28 parts of oyster, 6 parts of sea clam shell and 4 parts of platycodon grandiflorum.

Preferably, the pharmaceutical composition is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 8 parts of radix bupleuri, 3 parts of flos Pruni mume, 16 parts of trichosanthes kirilowii Maxim, 10 parts of poria cocos, 50 parts of corn stigma, 8 parts of donkey-hide gelatin, 6 parts of rhizoma bletillae, 10 parts of oyster, 13 parts of sea clam shell and 6 parts of platycodon grandiflorum.

The invention also provides application of the pharmaceutical composition in preparing a pharmaceutical composition for treating lung cancer.

The traditional Chinese medicine generally considers that the incidence of the lung cancer is mainly caused by the imbalance of yin and yang of internal organs, but in the aspect of medication, the emphasis is on tonifying qi and blood to achieve the aim of tonifying the lung, or the emphasis is on tonifying qi and nourishing yin; the traditional Chinese medicine considers that yin and yang are mutually used, namely that the solitary yin does not grow into the solitary yang; the above treatment guidelines mainly provide for tonifying the viscera as a whole or nourishing yin in accordance with the viscera, and thus the problem of yin-yang disharmony of the viscera cannot be solved fundamentally; the American ginseng is used as a monarch drug for tonifying middle-jiao and lung-yin, the radix bupleuri and the flos mume have the effects of regulating yin and yang of viscera, calming the liver and harmonizing stomach and regulating qi activity; the trichosanthes kirilowii maxim, the poria cocos and the corn stigma have the effects of clearing heat and removing phlegm, relieving chest stuffiness and dissipating stagnation, moistening dryness and lubricating intestines, and inducing diuresis and excreting dampness, so that phlegm is reduced and dampness is induced, no accumulation of dampness is caused, phlegm is formed by accumulation of dampness, no accumulation of phlegm-dampness is caused, and no accumulation of lung accumulation is caused, and the source of phlegm generation is thoroughly blocked as a ministerial drug; colla Corii Asini, rhizoma Bletillae, Concha Ostreae, Concha Meretricis Seu Cyclinae with lung heat clearing away, phlegm eliminating, hard lump softening, stagnation eliminating, blood replenishing, yin nourishing, dryness moistening, hemostasis, lung tonifying, and detumescence promoting effects; opening the lung of the platycodon grandiflorum to lift qi is yellow millet with various medicines, and carrying the medicine to float upwards to reach the disease as a guiding medicine; the medicine has clear division of labor and clear assistant and guide relationship, can effectively regulate yin and yang of viscera and block the source of phlegm generation, achieves the aim of treating exterior diseases by the mutual matching of assistant medicines and ministerial medicines, has the characteristics of obvious treatment effect, treatment focusing on relieving both the secondary and primary symptoms and high cure rate.

The traditional Chinese medicine can be directly obtained from the market. The invention can be decocted or the raw materials are respectively crushed and sieved according to the parts by weight, and then the raw materials are mixed and encapsulated and pressed into tablets, pills or dripping pills; or mixing with pharmaceutically acceptable carrier or diluent, making into capsule, and making into tablet, pill or dripping pill. The invention is mainly used for treating lung cancer; taking decoction as an example, one dose is taken every day, the decoction is decocted with water for three times, and about 840ml of juice is taken, and the juice is taken separately in the morning, the noon and the evening. One month is a treatment course, the rest is 4 days between two treatment courses, and the next treatment course is carried out, and generally 3 treatment courses are continuously taken; after the clinical symptoms and physical signs disappear, three treatment courses are consolidated; in particular, special groups such as pregnant women need to follow medical advice when taking the medicine, and no special adverse reaction is found at present. Treatment according to the present invention means treatment after onset of disease and does not represent intervention prior to onset of disease.

The traditional Chinese medicine composition is used for treating lung cancer, comprises 11 traditional Chinese medicines which are all directly available on the market, and has the following pharmacological drug properties:

american ginseng: sweet and slightly bitter in nature and cool in taste. It enters heart, lung and kidney meridians. The functional indications are as follows: nourish lung yin, clear deficiency fire, promote the production of body fluid to quench thirst. It is indicated for chronic cough due to lung deficiency, blood loss, dry throat, thirst, deficiency heat, restlessness and fatigue. (new materia Medica): tonify lung to reduce fire, promote generation of body fluid, relieve restlessness and fatigue. It is suitable for deficiency with fire. ' ② examination of drug Properties: nourishing yin and abating fever. Ginger processed product has effects of invigorating qi, and strengthening body resistance. (iii) renewal of materia Medica: treating excessive lung fire, cough with excessive phlegm, qi deficiency relieving asthma, blood loss, overstrain, essence securing and tranquilization, and various deficiency of production. 'materia Medica' expedition of materia Medica: clearing lung and kidney, cooling heart and spleen to reduce pathogenic fire, relieving summer heat and relieving alcoholism. "xi Lu of Yi Xue Zhong Can" (Western records of medicine): it can tonify qi system and tonify blood system. ".

Bupleuri radix has cool nature and sweet taste. Meridians enter liver and gallbladder meridians. The functional indications are as follows: harmonize exterior and interior, soothe liver and raise yang. It is used to treat alternating cold and heat, fullness in chest, hypochondriac pain, bitter taste in mouth, deafness, headache, blurred vision, malaria, prolapse of anus, menoxenia, and metroptosis. (I) Ben Jing: "governing qi accumulation in the stomach and intestine of heart, abdomen, food accumulation, pathogenic factors of cold and heat, old and new. ' 2 ' Biyu ': ' relieving restlessness and fever in the lower part of the heart due to typhoid fever, excessive phlegm-heat and fructification, adverse qi in the chest, qi stagnation between five zang organs, large intestine stagnation, water swelling and damp arthralgia and spasm. It can also be used as bath soup. (iii) treatise on herb Property: treating heat-induced fatigue, arthralgia, heat, shoulder and back pain, blood and qi circulation promotion, fatigue, emaciation and emaciation; it is mainly used for descending qi to promote digestion, and it is usually used after being decocted alone, because the interior and exterior heat are not relieved. 'Qianjin Fang': miao juice is used for treating deafness and poured into ears. "the four-tone materia Medica": "directing phlegm and billows, and feeling of fullness in chest and hypochondrium". 'Rihuazi Bencao': nourishing five strains and seven impairments, relieving restlessness and arresting convulsion, tonifying qi, eliminating phlegm and relieving cough, moistening heart and lung, replenishing essence and supplementing marrow, treating warm diseases in the day, causing mania and exhaustion, fullness in chest and hypochondrium and amnesia. Seventhly, pearl sac: it is indicated for the cold and heat in the gallbladder, not removed from the tip of Bupleurum root. ' Yi Xue Qi Yuan (medical inspiration): to remove consumptive disease and feverish sensation in chest, relieve muscular heat and remove morning tidal fever. Ninthly, Yunnan materia Medica: "Shanghai Huohan Jiefang exterior syndrome", which can remove the alternating of six channel pathogenic heat and paralysis, remove the pathogenic heat of liver and tuberculosis heat, move the adverse qi of liver channel and stop the pain of liver qi in the left hypochondrium, and can regulate menstruation when treating blood heat fever of women. For sweating, tender pistil is used, and root is used for deficiency heat and regulating menstruation. ' r (compendium): for curing sinking of yang-qi, calming liver, gallbladder, triple energizer, enveloping fire, headache, dizziness, blurred vision, red pain, nebula, deafness and tinnitus, malaria, fat, qi, chills and fever, women's heat entering blood chamber, irregular menstruation, residual heat of infant variola, malnutrition with dyspnea and fever. ".

Calyx Seu fructus Pruni mume: bitter taste and slightly warm nature. It enters liver, stomach and lung meridians. The functional indications are as follows: promoting qi and blood circulation, relaxing muscles and tendons, smoothing collaterals, soothing liver, relieving depression, stimulating appetite, and promoting fluid production. Is mainly used for treating depression and vexation; pain of liver and stomach qi, globus hystericus, scrofula and sore.

Full trichosanthes kirilowii maxim: sweet and bitter taste and cold nature. It enters lung, stomach and large intestine meridians. The functional indications are as follows: moisten lung, resolve phlegm, dissipate nodulation and smooth intestine. It is used to treat cough due to phlegm-heat, thoracic obstruction, chest stagnation, consumptive lung disease, hemoptysis, diabetes, jaundice, constipation, and early stage carbuncle. (ii) Bie Lu: "governing chest bi-arthralgia". ' ② Ben draft Jing: "Zhu Xiao Ke". (iii) becoming void: to relieve stagnated heat in chest. 'the treatise on the exogenous febrile diseases': for pyretic pulmonary disease, manifested as red and scanty output, tiglophobia. "the essence of the product Congjing" (essence of the product): to resolve phlegm and resolve carbuncle. 'compendium': moisten lung dryness and descend fire. For cough, remove phlegm, relieve sore throat, resolve abscess and sore. Seventhly, Jiangsu plant medicine will: treat edema. 'Yili' Shanxi Chinese medicine Zhi (Chinese medicine of Shanxi): the melon pulp is used for washing hands and is used for treating frost cracking. "usage and dosage: oral administration: decoct 9-20 g.

Tuckahoe, poria cocos: sweet and bland in flavor and mild in nature. It enters heart, spleen and lung meridians. The functional indications are as follows: excrete dampness and promote diuresis, benefit spleen and stomach, calm heart and induce tranquilization. It is indicated for difficulty in micturition, edema, abdominal distention, expectoration, emesis, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia. ' governing adverse qi in chest and hypochondrium, worry anger fright, fear and palpitation, pain in heart, chills and fever, dysphoria, cough, scorched mouth and dry tongue, and diuresis. ② Biyu (miscellaneous records) for treating diabetes, good sleep, abdomen, dripping, phlegm and water in diaphragm, edema and stranguria accumulation. Open the chest, regulate the qi of the zang-organs, suppress the pathogenic kidney, nourish yin, benefit strength, and keep the mind in mind. ③ treatise on the treatise on herb Property, promote appetite, stop vomiting and improve mind. Governing consumptive lung disease with phlegm accumulation. It is indicated for infantile convulsion, fullness and distention of heart and abdomen, and heat stranguria of women. 'Rihuazi Bencao' for nourishing five kinds of overstrain and seven kinds of injuries, preventing miscarriage, warming waist and knee, promoting mentality and improving intelligence and relieving amnesia. Fifth, Shang Han Ming theory, water seepage delays spleen. Sixthly, the medical inspiration shows that the traditional Chinese medicine mainly has the effects of removing dampness, benefiting blood between waist and navel and regulating the middle warmer and tonifying qi. It is indicated for yellow or red urine. In Yun from the formula of the main indications, it can stop diarrhea, remove deficiency heat, open striae and promote the production of body fluid. The formula of the formula is ' the formula of ' discharging the bladder and benefiting the spleen and the stomach '. It is indicated for renal stagnation and dolphin. 'the prescription' is mainly used for treating palpitation and twitching of muscle twitching and treating dizziness and dysphoria. ".

The corn stigma is sweet in nature and mild in taste. The functional indications are as follows: induce diuresis, purge heat, pacify liver, and promote bile flow. It can be used for treating nephritis, edema, tinea pedis, icterohepatitis, hypertension, cholecystitis, cholelithiasis, diabetes, hematemesis, epistaxis, nasosinusitis, and acute mastitis. (Dian nan Ben Cao): "Wide intestine and descending Qi". It is used to treat female nodules of breast, galactostasis, red swelling and pain, aversion to cold, fever, headache and physical difficulty. ' 2 ' Lingnan Biyao Biao ': it is used in combination with pork to treat diabetes. It is also indicated for dribbling urine with gravel, intolerable pain, and frequent decoction. (iii) modern practical traditional Chinese medicine: it is diuretic and is effective in treating nephropathy, edema, and diabetes. It is also an effective medicine for cholecystitis, cholelithiasis, hepatitis jaundice, etc. 'folk herbal compilation for common use': it can lower blood pressure, induce diuresis and relieve swelling. It is indicated for nosebleed and metrorrhagia. Fifth, Hebei herbs: it can be used for treating edema and tinea pedis. 'Zhejiang folk herb': promoting appetite, calming the liver and dispelling wind. Seventhly, the Chinese medicine of Sichuan is described: clearing away blood heat and promoting urination. It is indicated for jaundice, wind-heat, eruption, hematemesis and metrorrhagia. ".

E, donkey-hide gelatin: sweet in flavor and neutral in nature. It enters lung, liver and kidney meridians. The functional indications are as follows: nourish yin and enrich blood, prevent abortion. It is indicated for blood deficiency, cough due to asthenia, hematemesis, epistaxis, hematochezia, female irregular menstruation, metrorrhagia, fetal leakage. (I) Ben Jing: "governing heart and abdominal metrorrhagia, fatigue with extreme sprinkle as malaria, low back and abdominal pain, soreness and pain of limbs, and female bleeding. Preventing miscarriage. Can be taken for a long time to replenish qi. ' 2 ' Biyu ': "husband has lower abdominal pain, asthenia, emaciation, deficiency of yin-qi, soreness of the feet, and nourishing liver-qi. (iii) treatise on herb Property: to strengthen the muscles and bones, to tonify qi and check dysentery. 'Qianjin dietotherapy': treat strong wind. ' Boss washing: for treating wind-toxin-cutting bone joint pain, groaning and non-curing, it is taken with ease. 'Rihuazi Bencao': it is indicated for rhinorrhea, hematemesis, intestinal wind, bloody dysentery, metrorrhagia and leukorrhagia. Seventh, the compendium: it can be used for treating hematemesis, epistaxis, bloody stranguria, hematuria, intestinal wind, and dysentery. Female blood pain, blood withering, irregular menstruation, no seed, metrorrhagia, leukorrhagia, prenatal and postnatal diseases. All wind diseases of men and women, bone joint pain, edema of water and gas, consumptive disease, cough, dyspnea, consumptive lung disease, saliva, bloody pus and carbuncle, cellulitis and pyogenic infections. Harmonizing blood and nourishing yin, dispelling pathogenic wind and moistening dryness, eliminating phlegm and clearing lung-heat, promoting urination, and regulating large intestine. "steel supplement": treating lumbago due to internal injury, strengthening tendons, replenishing essence and invigorating kidney. ".

Rhizoma bletillae is sweet in nature, bitter in taste and slightly cool. The functional indications are as follows: tonify lung, stop bleeding, resolve swelling, promote granulation, heal wound. It is indicated for hemoptysis due to lung injury, epistaxis, bleeding due to incised wound, carbuncle, cellulitis, toxic swelling, ulcer, burn due to hot liquid and fire, and rhagadia manus et pedis. (I) Ben Jing: "this refers to the swollen and malignant sores, gangrene of finger or toe, impairment of yin and death of muscles, and retention of pathogenic qi in the stomach, and mild miliaria. ' 2 ' Biyu ': "Jiefengxianwei Jiechiichong". (iii) treatise on herb Property: "treat accumulation of heat without diminishing and govern yin deficiency with atrophy", treat blackish patch on face, make people's muscles slippery. 'Tang Ben Cao': it is applied after being chewed after being split into chapped hands and feet. "Rihuazi Bencao": the medicine has the effects of relieving convulsion, blood pathogen, dysentery, red eyes, symptom knot, back, scrofula, intestinal wind, hemorrhoid gall, knife and arrow sore, warm malaria, bloody dysentery, soup fire sore, promoting granulation and relieving pain, and rheumatism. ' The book draft Jing: it is indicated for non-healing after treating incised wound, and it is used in abscess and deep-rooted carbuncle. ' Li Gao: "stop lung blood". 'Yinan Bencao': for tuberculosis, it can tonify lung deficiency, relieve cough, eliminate pulmonary tuberculosis and hemoptysis, and astringe lung qi. Ninthly, Chinese medicine implantation pictorial identification: for silicosis. ".

Oyster shell: sweet, salty and neutral in nature. It enters liver and kidney meridians. The functional indications are as follows: astringe yin, subdue yang, check sweating, astringe essence, resolve phlegm and soften hard masses. It is indicated for fright epilepsy, vertigo, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula and goiter. Can be used for treating palpitation, insomnia, vertigo, tinnitus, scrofula, subcutaneous nodule, lump in the abdomen, spontaneous perspiration, night sweat, nocturnal emission, metrorrhagia, gastralgia, and pantothenic acid. Calcined oyster shell astringes and astringes. Can be used for treating spontaneous perspiration, night sweat, spermatorrhea, metrorrhagia, gastralgia, and acid regurgitation. (1) Nourishing yin and suppressing yang: unprocessed for tidal fever, night sweat, headache, vertigo, dysphoria and insomnia due to yin deficiency and yang hyperactivity. (2) Softening hardness and dissipating nodulation: unprocessed is used for scrofula and lumps. (3) Astringency inducing: calcined for hyperhidrosis, seminal emission, leukorrhagia, metrorrhagia and diarrhea, it is often combined with Long Gu. (4) It can also be used for gastric hyperacidity, and is often combined with cuttlefish bone. (I) Ben Jing: "Cold-heat syndrome manifested as fever, malaria, fright anger anger, spasm and rat fistula, and leukorrhagia of female. Strengthen the bone joint after long-term administration. ' 2 ' Biyu ': "removing retained heat in the joints and relieving deficiency heat with restlessness, restlessness; arresting sweating, relieving heart pain, stopping thirst and removing old blood. Astringe large and small intestines, relieve constipation, treat diarrhea, throat obstruction, cough, and distention and fullness in the hypochondrium. (iii) treatise on herb Property: "is used mainly for treating metrorrhagia of women. Stop night sweat, dispel wind-heat and alleviate pain. It can be used for treating warm malaria. It is also combined with Du Zhong to stop night sweat. For patients with deficiency syndrome and excessive heat, rehmanniae radix and herba Chloranthi Serrati can be added. 'materia Medica' Shi Yi: pounding into powder, and powdering, mainly for night sweat of adults and children, and taking ephedra root, fructus cnidii and dried ginger as powder, and removing sweat from yin. Fifth, the materia Medica of sea drugs: mainly treats spermatorrhea, consumptive disease and loss, tonifies kidney and strengthens vital energy, prevents steatorrhea, removes dysphoria with smothery sensation, treats typhoid fever and phlegm, can nourish the body and calm the nerves, and treats infantile convulsion and epilepsy. 'Zhu Sac': "Runfu Jie". It is also indicated for leukorrhagia, warm malaria, sores and swelling, and is a herb for softening hardness and astringing. Seventh, the compendium: resolving phlegm and softening hard mass, clearing heat and eliminating dampness, relieving heart and spleen qi pain, dysentery, red and white turbidity, eliminating hernia and mass, goiter and tuberculosis. ' the xi Lu of the Yi Xue Zhong Can (the Western Lu of the medical profession): to stop hiccup. Ninthly modern practical traditional Chinese medicine: the Chinese medicinal preparation is an antacid, has the effects of harmonizing stomach and relieving pain, and is used for treating hyperacidity, asthenia, night sweat, palpitation, twitching, meat twitching and the like. It is effective in treating calcium deficiency and pulmonary tuberculosis in pregnant women and children. ".

Clam shell: mild in nature and salty in taste. It enters the Taiyang and Yangming meridians of hand and foot. The functional indications are as follows: clear heat, induce diuresis, resolve phlegm, soften hard masses. It is used to treat heat-phlegm, asthma, cough, edema, gonorrhea, goiter, tumor, accumulation, blood stasis, chest pain, bloody dysentery, hemorrhoid, metrorrhagia, metrostaxis, and leukorrhagia. (I) Ben Jing: "cough with dyspnea, fullness and irritability, chest pain with chills and fever". ' 2 ' Biyu ': treat impotence. (iii) treatise on herb Property: it is indicated for edema of water and dampness, urination, cough, adverse rising of qi and goiter. 'Tang Ben Cao': "mainly make the twelve water full and sharp, benefiting bladder and large and small intestines. "the four-tone materia Medica": to relieve thirst and moisten five zang organs. 'Rihuazi Bencao': it is indicated for vomiting, impotence, distending sensation in chest and hypochondrium, lumbago, five hemorrhoids, metrorrhagia and leukorrhagia. Seventh, the compendium: clearing heat and promoting diuresis, eliminating phlegm and fluid retention, eliminating accumulation, removing bloody dysentery, blood stasis and chest of women, typhoid fever and sweating, tetany and paralysis of middle-jiao Feng. 'modern practical Chinese medicine': it is indicated for stranguria and has the action of inducing diuresis. ".

Balloon flower: pungent, mild and bitter in property. It enters lung and stomach meridians. The functional indications are as follows: to disperse lung qi, dispel phlegm and expel pus. It is indicated for cough due to exogenous pathogenic factors, swollen and sore throat, lung abscess with pus, fullness in chest, hypochondriac pain, dysentery and abdominal pain. (I) Ben Jing: "mainly treat chest and hypochondriac pain such as knife prick, abdominal fullness, borygmus and claustrophobia, palpitation due to fright. ' 2 ' Biyu ': benefiting the five internal organs and the intestines, replenishing blood and qi, removing cold and heat and wind arthralgia, warming middle energizer and removing food, and treating throat and pharyngalgia. (iii) treatise on herb Property: it is indicated for diarrhea, blood stasis, qi stagnation, accumulation and phlegm, lung heat, cough, dyspnea, abdominal cold and pain, nausea and infantile convulsions. ' Rihuazi materia Medica: ' all qi in the body, stopping cholera and twitching of tendons, distending pain in the heart and abdomen, tonifying five strains, nourishing qi, eliminating pathogenic factors and warming, tonifying deficiency and eliminating phlegm, breaking the abdominal mass, nourishing blood and expelling pus, and tonifying internal leakage and pharyngitis. "this herbal Yanyi": treat pulmonary abscess. 'Zhu Sac': treat sore throat, remove lung-qi and treat nasal obstruction. ' Li Gao: benefiting chest and diaphragm, (treating) throat qi obstruction and pain, breaking stagnation of qi and accumulation, removing lung wind-heat, clearing head and eyes, and benefiting orifices. 'gang mu': "the main symptoms are aphtha in the mouth and tongue and red eye swelling and pain. Ninthly, experience identification method of traditional Chinese medicine form: "lactation promotion". ".

The invention is used for treating lung cancer, achieves the purpose of blocking the source of phlegm generation by tonifying viscera, adjusting yin and yang of viscera, supplementing heat clearing and phlegm removing, chest stuffiness relieving and stagnation dissipating, dryness moistening and intestine smoothing, and diuresis and dampness excreting, and has the advantages of treating both principal and secondary aspect of disease, obvious effect, difficult relapse after healing and high cure rate by matching adjuvant drugs and guiding drugs.

Detailed Description

The invention relates to a pharmaceutical composition for treating lung cancer and application thereof, wherein the pharmaceutical composition is prepared from the following raw materials: american ginseng, radix bupleuri, flos Pruni mume, fructus Trichosanthis, Poria, stigma Maydis, colla Corii Asini, rhizoma Bletillae, Concha Ostreae, Concha Meretricis Seu Cyclinae and radix Platycodi.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 15-90 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 3-15 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 15-30 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 3-6 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 4-6 parts of American ginseng, 5-9 parts of radix bupleuri, 3-4 parts of flos Pruni mume, 15-20 parts of trichosanthes kirilowii Maxim, 9-11 parts of poria cocos, 20-30 parts of corn stigma, 5-9 parts of donkey-hide gelatin, 5-6 parts of rhizoma bletillae, 9-18 parts of oyster, 9-15 parts of clam shell and 6-9 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: the traditional Chinese medicine composition comprises, by weight, 4 parts of American ginseng, 9 parts of radix bupleuri, 4 parts of flos Pruni mume, 19 parts of trichosanthes kirilowii Maxim, 11 parts of poria cocos, 20 parts of corn stigma, 6 parts of donkey-hide gelatin, 5 parts of rhizoma bletillae, 17 parts of oyster, 10 parts of clam shell and 7 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 60-90 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 6-15 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3-5 parts of American ginseng, 3-6 parts of radix bupleuri, 4-5 parts of flos Pruni mume, 9-14 parts of trichosanthes kirilowii Maxim, 11-15 parts of poria cocos, 70-80 parts of corn stigma, 3-6 parts of donkey-hide gelatin, 8-12 parts of rhizoma bletillae, 19-30 parts of oyster, 6-8 parts of clam shell and 3-5 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 5 parts of American ginseng, 4 parts of radix bupleuri, 5 parts of flos Pruni mume, 10 parts of trichosanthes kirilowii Maxim, 15 parts of poria cocos, 75 parts of corn stigma, 3 parts of donkey-hide gelatin, 12 parts of rhizoma bletillae, 28 parts of oyster, 6 parts of sea clam shell and 4 parts of platycodon grandiflorum.

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 8 parts of radix bupleuri, 3 parts of flos Pruni mume, 16 parts of trichosanthes kirilowii Maxim, 10 parts of poria cocos, 50 parts of corn stigma, 8 parts of donkey-hide gelatin, 6 parts of rhizoma bletillae, 10 parts of oyster, 13 parts of sea clam shell and 6 parts of platycodon grandiflorum.

In order to explain the present invention more clearly, the present invention will now be further described with reference to specific examples. Specific examples are as follows:

example one

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 2 parts of American ginseng, 10 parts of radix bupleuri, 6 parts of flos Pruni mume, 8 parts of trichosanthes kirilowii Maxim, 16 parts of poria cocos, 14 parts of corn stigma, 2 parts of donkey-hide gelatin, 16 parts of rhizoma bletillae, 8 parts of oyster, 5 parts of sea clam shell and 10 parts of platycodon grandiflorum.

Example two

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 7 parts of American ginseng, 2 parts of radix bupleuri, 2 parts of flos Pruni mume, 21 parts of trichosanthes kirilowii Maxim, 8 parts of poria cocos, 91 parts of corn stigma, 10 parts of donkey-hide gelatin, 2 parts of rhizoma bletillae, 31 parts of oyster, 16 parts of sea clam shell and 2 parts of platycodon grandiflorum.

EXAMPLE III

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 3 parts of radix bupleuri, 5 parts of flos Pruni mume, 9 parts of trichosanthes kirilowii Maxim, 9 parts of poria cocos, 15 parts of corn stigma, 3 parts of donkey-hide gelatin, 3 parts of rhizoma bletillae, 9 parts of oyster, 6 parts of sea clam shell and 3 parts of platycodon grandiflorum.

Example four

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3 parts of American ginseng, 9 parts of radix bupleuri, 3 parts of flos Pruni mume, 20 parts of trichosanthes kirilowii Maxim, 9 parts of poria cocos, 90 parts of corn stigma, 9 parts of donkey-hide gelatin, 15 parts of rhizoma bletillae, 30 parts of oyster, 15 parts of sea clam shell and 9 parts of platycodon grandiflorum.

EXAMPLE five

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 4.5 parts of American ginseng, 6 parts of radix bupleuri, 4 parts of flos Pruni mume, 14.5 parts of trichosanthes kirilowii Maxim, 12 parts of poria cocos, 52.5 parts of corn stigma, 6 parts of donkey-hide gelatin, 9 parts of rhizoma bletillae, 19.5 parts of oyster, 10.5 parts of clam shell and 6 parts of platycodon grandiflorum.

EXAMPLE six

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3 parts of American ginseng, 3 parts of radix bupleuri, 5 parts of flos Pruni mume, 9 parts of trichosanthes kirilowii Maxim, 9 parts of poria cocos, 15 parts of corn stigma, 3 parts of donkey-hide gelatin, 3 parts of rhizoma bletillae, 9 parts of oyster, 6 parts of sea clam shell and 3 parts of platycodon grandiflorum.

EXAMPLE seven

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 9 parts of radix bupleuri, 3 parts of flos Pruni mume, 20 parts of trichosanthes kirilowii Maxim, 15 parts of poria cocos, 30 parts of corn stigma, 9 parts of donkey-hide gelatin, 6 parts of rhizoma bletillae, 30 parts of oyster, 15 parts of sea clam shell and 9 parts of platycodon grandiflorum.

Example eight

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 4.5 parts of American ginseng, 6 parts of radix bupleuri, 4 parts of flos Pruni mume, 14.5 parts of trichosanthes kirilowii Maxim, 12 parts of poria cocos, 22.5 parts of corn stigma, 6 parts of donkey-hide gelatin, 4.5 parts of rhizoma bletillae, 19.5 parts of oyster, 10.5 parts of sea clam shell and 6 parts of platycodon grandiflorum.

Example nine

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 5 parts of radix bupleuri, 3 parts of flos Pruni mume, 15 parts of trichosanthes kirilowii Maxim, 9 parts of poria cocos, 20 parts of corn stigma, 5 parts of donkey-hide gelatin, 5 parts of rhizoma bletillae, 9 parts of oyster, 9 parts of sea clam shell and 6 parts of platycodon grandiflorum.

Example ten

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: the traditional Chinese medicine composition comprises, by weight, 4 parts of American ginseng, 9 parts of radix bupleuri, 4 parts of flos Pruni mume, 20 parts of trichosanthes kirilowii Maxim, 11 parts of poria cocos, 30 parts of corn stigma, 9 parts of donkey-hide gelatin, 6 parts of rhizoma bletillae, 18 parts of oyster, 15 parts of clam shell and 9 parts of platycodon grandiflorum.

EXAMPLE eleven

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 5 parts of American ginseng, 7 parts of radix bupleuri, 3.5 parts of flos Pruni mume, 17.5 parts of trichosanthes kirilowii Maxim, 10 parts of poria cocos, 25 parts of corn stigma, 7 parts of donkey-hide gelatin, 5.6 parts of rhizoma bletillae, 13.5 parts of oyster, 12 parts of clam shell and 7.5 parts of platycodon grandiflorum.

Example twelve

EXAMPLE thirteen

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 9 parts of radix bupleuri, 3 parts of flos Pruni mume, 9 parts of trichosanthes kirilowii Maxim, 9 parts of poria cocos, 60 parts of corn stigma, 3 parts of donkey-hide gelatin, 6 parts of rhizoma bletillae, 9 parts of oyster, 6 parts of sea clam shell and 3 parts of platycodon grandiflorum.

Example fourteen

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3 parts of American ginseng, 3 parts of radix bupleuri, 5 parts of flos Pruni mume, 20 parts of trichosanthes kirilowii Maxim, 15 parts of poria cocos, 90 parts of corn stigma, 9 parts of donkey-hide gelatin, 15 parts of rhizoma bletillae, 30 parts of oyster, 15 parts of sea clam shell and 9 parts of platycodon grandiflorum.

Example fifteen

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 4.5 parts of American ginseng, 6 parts of radix bupleuri, 4 parts of flos Pruni mume, 14.5 parts of trichosanthes kirilowii Maxim, 12 parts of poria cocos, 75 parts of corn stigma, 6 parts of donkey-hide gelatin, 10.5 parts of rhizoma bletillae, 19.5 parts of oyster, 10.5 parts of sea clam shell and 6 parts of platycodon grandiflorum.

Example sixteen

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 5 parts of American ginseng, 3 parts of radix bupleuri, 5 parts of flos Pruni mume, 9 parts of trichosanthes kirilowii Maxim, 11 parts of poria cocos, 70 parts of corn stigma, 3 parts of donkey-hide gelatin, 8 parts of rhizoma bletillae, 19 parts of oyster, 6 parts of sea clam shell and 3 parts of platycodon grandiflorum.

Example seventeen

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 3 parts of American ginseng, 6 parts of radix bupleuri, 4 parts of flos Pruni mume, 14 parts of trichosanthes kirilowii Maxim, 15 parts of poria cocos, 80 parts of corn stigma, 6 parts of donkey-hide gelatin, 12 parts of rhizoma bletillae, 30 parts of oyster, 8 parts of sea clam shell and 5 parts of platycodon grandiflorum.

EXAMPLE eighteen

The pharmaceutical composition for treating lung cancer is prepared from the following raw materials in parts by weight: 4 parts of American ginseng, 4.5 parts of radix bupleuri, 4.5 parts of flos Pruni mume, 11.5 parts of trichosanthes kirilowii Maxim, 13 parts of poria cocos, 75 parts of corn stigma, 4.5 parts of donkey-hide gelatin, 10 parts of rhizoma bletillae, 24.5 parts of oyster, 7 parts of clam shell and 4 parts of platycodon grandiflorum.

Example nineteen

Example twenty

The above examples are merely illustrative for clearly illustrating the present invention and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art upon reference to the above description. It is not necessary or necessary to exhaustively enumerate all embodiments herein, and obvious variations or modifications can be made without departing from the scope of the invention as claimed.

Case 1: name: age certain, sex male, age 47 years, address: luoyang city, Koelreum paniculata, Henan province. And (3) diagnosis: "Right squamous cell lung carcinoma and obstructive pulmonary inflammation". The patient has no obvious induction of chest distress and pain, cough and expectoration, bloody sputum, no nausea and vomiting in 8 months in 2010, and is diagnosed in Beijing Shun Hospital, and the chest CT shows that the anterior segment of the superior right lung lobe and the medial segment of the middle lobe have soft tissue shadow, the CT value is about 45HU, lobular division is shown, low-density shadow is seen in the anterior segment of the superior right lung lobe and the distal bronchus of the medial segment of the superior right lung lobe are blocked. Swollen lymph nodes are seen in the mediastinum. The diagnosis suggestion shows that the occupation of the anterior segment and the medial segment of the right lung superior lobe is the obstructive inflammation of the right lung superior lobe and the enlargement of the longitudinal lymph node. The symptoms are slightly improved by applying symptomatic treatment such as anti-inflammation and the like. Fever appears in 2010 at 9 and 25 months, the highest temperature is 38.3 ℃, the doctor visits a Chinese-Japanese friendly hospital, and the chest enhancement CT shows that: the upper lobe of the right lung has a soft tissue mass image, the size is about 104cm by 7.7cm, the margin is unclear, the enhancement is uneven, and the boundary with the pericardium is unclear. Multiple swollen lymph nodes are found in the mediastinum and fused into clusters. The diagnosis suggestion includes the invasion of the right superior pulmonary artery, the metastasis of mediastinal and right pulmonary lymph nodes and the possibility of local pericardial involvement. Bronchitis of lower lobes of the left lung with phlegm embolism. Brain nuclear magnetic resonance (Zhongri friendly Hospital) showed no clear abnormalities in craniocerebral MRI flat scans. Chinese medicine treatment (details are not shown) is returned to local Chinese medicine hospital after the symptomatic support treatment. The patient is admitted to Zhengda affiliated room 10 and 16 days 2010, relevant auxiliary examination and lung tissue biopsy are perfected, the patient is confirmed to be 'right squamous cell lung carcinoma', chemotherapy is performed by using a scheme of 'paclitaxel 313mg dl + carboplatin 800mg d 2', symptomatic support treatment such as liver protection, stomach protection and vomiting prevention is assisted, then chemotherapy such as 'Carrilizumab 200mg ivgtt d1q3w + Apatinib 250mg qd po' is continuously applied to the Zhengda affiliated room, the disease condition is gradually worsened after repeated chemotherapy in the Zhengda affiliated room for two years, the carcinoembryonic antigen is increased to 13.4ng/mL from the original 8.19ng/mL, the chemotherapy fails, the recovery disease is reported to be diagnosed in the hospital 9 and 18 days 2012, and the outpatient clinic is collected as 'right squamous cell lung carcinoma and obstructive pulmonary inflammation'. The treatment process comprises the following steps: the diagnosis is carried out according to the patient's condition and the dialectical treatment of traditional Chinese medicine: and (3) master certificate: yellow face, shortness of breath, cough, hemoptysis, bloody sputum, wheezing, chest distress, chest pain, even pain at night, immobility, hypochondriac fullness, excessive qi, dark tongue, and thready and unsmooth pulse. And (3) pathogenesis analysis: the essential foundation of lung cancer is qi deficiency due to pathogenic accumulation, as in Yi Zong Bie Yi (prerequisites for medical treatment and accumulation): the accumulation of qi may lead to deficiency of the lung qi, impairment of lung qi due to consumption of pathogenic qi, qi stagnation, disorder of ascending and descending, or over-exertion, lung qi and lung yin deficiency, exogenous pathogenic factors entering due to deficiency, retention of exogenous pathogenic factors, and qi stagnation, and finally stagnation of the blood in the lung. The chronic disease has the symptoms of phlegm-dampness coagulation blocking the airway, yellow face, short breath and hypodynamia, thin pulse which is caused by insufficient healthy qi and deficiency of both qi and blood, cough, dyspnea, chest distress and suffocation, fullness in the lower rib and stagnation of qi due to depression of the liver, hemoptysis, blood in phlegm, chest pain, severe pain at night, immobility, dark tongue texture and unsmooth pulse which are caused by internal retention of phlegm, blood stasis and water-dampness. The traditional Chinese medicine diagnoses the lung accumulation, the lump in the abdomen, the deficiency of both qi and blood, qi stagnation and blood stasis, turbid phlegm, water dampness and internal stagnation. The therapeutic principle of traditional Chinese medicine is as follows: invigorating qi and blood, promoting blood circulation, removing blood stasis, promoting diuresis, eliminating phlegm, and resisting cancer. By adopting the fifteenth embodiment of the invention, the usage is as follows: one dose of the above traditional Chinese medicines is taken every day, the decoction is decocted for three times, and about 840ml of juice is taken, and the decoction is taken for three times in the morning, at noon and at night. After a patient takes the traditional Chinese medicine for one week, cough and expectoration symptoms are obviously relieved, the appetite is increased, bitter taste and dry mouth symptoms disappear, after the patient takes the traditional Chinese medicine for two months, the mental state of the patient is obviously improved, the complexion is good, physical discomfort symptoms disappear completely, the patient requires to be reviewed in an Zhengda attached hospital, and review results show that: carcinoembryonic antigen is reduced to 6.17ng/mL, other indexes are basically normal, and CT examination shows that: the right squamous cell lung carcinoma and obstructive pulmonary inflammation are obviously reduced compared with the 2010-10-16 day tablets, and the patient is discharged after continuously consolidating the treatment for half a year without changing the prescription and is not relapsed to date.

Case 2: name: certain plum, sex: male, age: age 68, address: yuzhou city, Henan province. And (3) diagnosis: central lung cancer with obstructive inflammation of the right upper lung lobes. In 9 months in 2013, the patient is not relieved by infusing antibiotics and phlegm-resolving medicines in a local clinic for 9 months due to cough, expectoration, bloody sputum and hypodynamia, and then goes to a local hospital for treatment, and CT shows that: the upper right lung lobe can see multiple small nodular dense images, and the lung cancer is suspected, and for further diagnosis, the patient is transferred to a Beijing tumor hospital and is subjected to whole body PET-CT examination in the Beijing tumor hospital, and the result is shown as follows: fasting for more than 6 hours, measuring fasting blood sugar 4.8mmol/L, injecting imaging agent 18F-FDG9.7mCi intravenously, standing for 80 minutes, performing whole body PET/CT tomographic imaging, fusing images with the same machine, and clearly imaging all parts of the whole body. A nodular FDG uptake increase image can be seen at the opening of the upper right lung lobe bronchus, the diameter is about 1.0cm, the SUV maximum value is 5.3, the position is shown to be a soft tissue density nodule image by CT, the boundary is not clear, the upper right lung lobe bronchus is blocked, and the upper right lung lobe permeability is increased. Multiple small nodular dense images can be seen in the upper right lung lobe, and no obvious abnormality in FDG distribution is seen. The lower area of the right suprapulmonary lobe near the chest model can be seen with a small nodule shadow, the diameter is about 0.7cm, and no obvious abnormality is seen in the FDG distribution. Multiple lobular space thickening shadows can be seen in the middle and lower lobes of the left and right lungs, and no obvious abnormality is seen in the FDG distribution. The bilateral hilum and mediastinum (4R, 5, 7 groups) were observed with increased lymph node shadow, the largest length was about 2.3cm, the density was slightly higher, some speckled calcification shadow was observed, PET indicated that the lymph node was FDG uptake increased shadow, and the SUV maximum was 6.7. Normal visualization of heart and great vessels revealed multiple spots and linear calcifications in the aortic and coronary walls. Bilateral pleura was thickened, and there was no definite signs of fluid accumulation in the pleural cavities on both sides. No significant abnormalities in bilateral axillary FDG uptake were seen. The liver shape and size are basically normal, and no obvious abnormality is found in the uptake of liver parenchyma FDG. Spleen and pancreas were normal in morphology and size, and no abnormal concentration of FDG was observed. The parenchyma density of the left kidney is uneven, the superior pole of the left kidney can see a quasi-circular low-density shadow with the diameter of about 2.3cm, and PET shows that the part is an FDG defect area; no obvious abnormality was seen in the density, size and FDG distribution of the right kidney parenchyma. The stomach was still full, the stomach wall was not thick, and no obvious abnormalities in FDG uptake were observed. Little physiological uptake was observed in the colon, and no apparent space occupying lesions were observed. No definite swollen lymph nodes and abnormal foci of FDG were found retroperitoneally and in the abdominal cavity. Bladder visualization was normal. No significant abnormalities in prostate morphology, size, density and FDG uptake were seen. There was no significant abnormality in FDG uptake in the bilateral inguinal region. The right basal ganglia region is seen as a low density mottled image, and PET shows that the above-mentioned region is an FDG sparse reduced region. The remnant brain was visualized normally, while the FDG distribution in the frontal, parietal, temporal, occipital, thalamus and bilateral cerebellum was approximately symmetrical, and no obvious areas of abnormally increased or decreased PDG uptake were observed. The low dose CT shows that no abnormal density shadow is seen in the residual brain parenchyma, and the sulcus, fissure and cisterna are not widened and expanded, and the internal density is as normal. The midline structure is centered, the uptake symmetry of the oropharyngeal bilateral walls FDG is increased, the oropharyngeal bilateral walls FDG are in a spot-shaped FDG dense focus, the SUV maximum value is about 3.6, CT shows that the pharyngeal lateral walls are slightly thickened, and the pharyngeal cavity normal contour exists. The nasopharyngeal part is normal in shape, and abnormal FDG extraction is not found. Thyroid morphology, size, density and FDG uptake were not significantly abnormal. No obvious abnormality is seen in FDG uptake of the whole body bone system, and hyperplasia and tippling of the cervical, thoracic and lumbar vertebral bodies can be seen in different degrees as shown by low-dose CT. And (4) conclusion: 1. combining clinic to consider central lung cancer with right upper lung lobe obstructive inflammation with node at upper right lung lobe bronchial opening accompanied with metabolism increase; 2. the metabolism of the nodes under the pleura near upper lobe of the right lung is not obviously abnormal, the inflammatory nodes are considered mostly, and the follow-up observation is recommended, wherein the interstitial change of the lower lobe in the left lung and the right lung is observed; arteriosclerosis; thickening of bilateral pleura; 3. left suprarenal cyst 4. softening focus of right basal ganglia; thickening of the oropharyngeal double-sided mucosa with increased metabolism, and inflammatory or physiological uptake is considered; 5. degeneration of the spine. Chemotherapy is given for more than one year, specific medicines are not good, the condition of the disease is gradually worsened, in order to seek traditional Chinese medicine, a patient is heard to introduce that the curative effect of treating the lung cancer in our hospital is obvious, so that the doctor visits the hospital 12 and 13 days before 2014, and the outpatient service is collected in our hospital by 'central lung cancer with obstructive inflammation of right upper lung lobes'. The treatment process comprises the following steps: the diagnosis after the treatment of the syndrome differentiation of the traditional Chinese medicine is as follows: lung disease (lung cancer). And (3) master certificate: pale complexion, mental fatigue, short breath, asthma, cough, blood-stained sputum, chest distress, chest pain, dark red tongue, and wiry and thready pulse. And (3) pathogenesis analysis: the lung-qi deficiency can lead to pale complexion, shortness of breath and wheezing; phlegm and blood stasis cause retention of water and dampness, accumulation of phlegm and stagnation of phlegm for a long time, obstruction of qi movement, and obstruction of qi movement to chest distress and pain, blood-stained phlegm, dark and red tongue, white and greasy coating, and wiry and thready pulse. Traditional Chinese medicine diagnosis: lung disease (lung cancer) -lung qi deficiency, phlegm-stasis and toxin accumulation. The therapeutic principle of traditional Chinese medicine is as follows: dispersing lung qi, regulating qi-flowing, removing blood stasis, clearing heat and eliminating phlegm;

by adopting the nineteenth embodiment of the invention, the usage is as follows: one dose of the above traditional Chinese medicines is taken every day, the decoction is decocted for three times, and about 840ml of juice is taken, and the decoction is taken for three times in the morning, at noon and at night. After a patient takes one dose of the medicine, more smelly fart is discharged, cough and expectoration are relieved, chest distress disappears, cough and blood-carrying symptoms in phlegm disappear after the patient continues taking the medicine for one month, physical discomfort symptoms disappear after the patient continues taking the medicine for two months, the patient can be treated for more than three months firmly, PET-CT examination is carried out, no tumor focus is found, and the patient is recovered and discharged. Follow-up was to date without recurrence.

Case 3: name: certain piece, sex: women, age 65 years, Nanyang City Seisan county. Cough after the patient is cooled in 2 months in 2010, the patient is subjected to symptomatic treatment such as inflammation diminishing and cough relieving in a local clinic, symptoms are gradually aggravated, and uncomfortable symptoms such as expectoration, hemoptysis, chest distress, hypodynamia, intolerance to cold, shortness of breath, asthma and suffocation are caused, and the left lung space occupation is found in a local hospital by CT examination for further diagnosis. The patient is diagnosed in Zhengzhou city hospital within 19 days in 3 months, and the chest CT shows that 1 lung cancer of the upper lobe of the left lung, multiple lymph nodes at mediastinum, 2, multiple micro nodules are generated on the two lungs, and small nodules at the front segment of the upper lobe of the right lung; and completing the pathological examination. Left lung cancer was diagnosed. The patients have no improvement after three courses of chemotherapy, and the patients have a visit from the hospital before introduction by friends on 8, 15 days in 2010, and the outpatient service is admitted to the hospital as 'left lung cancer'. The treatment process comprises the following steps: the diagnosis is carried out according to the patient's condition and the dialectical treatment of traditional Chinese medicine: and (3) master certificate: cough, hemoptysis, bloody sputum, dyspnea with movement, hypodynamia, spontaneous perspiration, aversion to cold, dark tongue with white fur, and deep and thready pulse. And (3) pathogenesis analysis: failure of the lung to disperse and descend due to lung qi deficiency and lung defense disorder can lead to failure of the lung to recover for a long time, resulting in water retention, phlegm accumulation, mass formation after a long time, and obstruction in the chest, resulting in chest distress and pain. Lung qi deficiency, asthenia, short breath, dyspnea, disorder of lung and defensive function, and weak striae; so it is weak, aversive to cold and spontaneous sweating. The traditional Chinese medicine diagnoses the lung accumulation, the lump in the abdomen, the deficiency of both lung and defensive qi, blood stasis, turbid phlegm, water dampness and internal stagnation. The therapeutic principle of traditional Chinese medicine is as follows: regulating lung and wei, promoting blood circulation, dispelling blood stasis, promoting diuresis, eliminating phlegm, and resisting cancer. By adopting the twenty embodiment of the invention, the usage is as follows: one dose of the above traditional Chinese medicines is taken every day, the decoction is decocted for three times, and about 840ml of juice is taken, and the decoction is taken for three times in the morning, at noon and at night. After the patient takes the traditional Chinese medicine for one week, the symptoms of cough and expectoration are obviously relieved, the appetite is increased, the symptoms of hypodynamia are improved, the chest pain is relieved, and the symptoms of asthma are improved; on the premise of not changing the prescription, the patient is discharged after continuously consolidating the treatment for more than half a year, and the patient does not relapse.

The invention is further described below in connection with clinical trials conducted in our hospital, the institute of Shaoyu, Dengzhou, Henan:

1. the selected cases are lung cancer patients in our hospital, 120 cases of nasal lung cancer patients, 78 cases of men and 42 cases of women are selected, and the course of the disease is 30 days to 10 months.

2. Diagnostic criteria: according to the national administration of traditional Chinese medicine, the standard of curative effect of traditional Chinese medicine diagnosis, the patient's condition and the PET/CT clinical manifestations.

3. The treatment method comprises the following steps: the medicine is taken according to the taking method of the invention every day, one dose is taken every day, the decoction is taken for three times, about 840ml of juice is taken, and the medicine is taken for three times in the morning, at noon and at night. One month is a course of treatment, rest for 4 days, and take 3 courses continuously until the clinical symptoms disappear, and then consolidate three courses. And was followed up for 3 months.

4. The evaluation standard of the curative effect is as follows:

(1) basically curing: the clinical symptoms completely disappear, the PET/CT examination result is normal, and no relapse occurs after 5 years of follow-up.

(2) And (3) relieving: the tumor range is reduced by more than 80 percent, the clinical symptoms basically disappear, and the disease is stable and does not relapse after the follow-up visit for 3 years.

(3) The obvious progress is as follows: the range is reduced by more than 60 percent and maintained for more than 3 years, the clinical symptoms basically disappear, and the follow-up illness state is stable for 3 years without relapse.

(4) And (4) invalidation: after six courses of treatment, no obvious change is seen, and the PET/CT examination result is not changed obviously.

5. The treatment effect is as follows: the invention is applied to 120 clinical cases of lung cancer patients for 3 courses of treatment until the clinical symptom signs disappear, the PET/CT examination result is normal, then the curative effect is consolidated, the treatment effect is evaluated by applying the curative effect evaluation standard: 72 cases are basically cured, about 60 percent is cured, 28 cases are relieved, about 23.3/%, 14 cases are obviously improved, about 11.7 percent is effectively improved, 6 cases are not effectively improved, about 5 percent is realized, and the total effective rate is about 95 percent.

Claims

1. A pharmaceutical composition for treating lung cancer, which is characterized in that: the pharmaceutical composition is prepared from the following raw materials: american ginseng, radix bupleuri, flos Pruni mume, fructus Trichosanthis, Poria, stigma Maydis, colla Corii Asini, rhizoma Bletillae, Concha Ostreae, Concha Meretricis Seu Cyclinae and radix Platycodi.

2. The pharmaceutical composition for treating lung cancer according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 15-90 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 3-15 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

3. The pharmaceutical composition for treating lung cancer according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 15-30 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 3-6 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

4. The pharmaceutical composition for treating lung cancer according to claim 3, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 4-6 parts of American ginseng, 5-9 parts of radix bupleuri, 3-4 parts of flos Pruni mume, 15-20 parts of trichosanthes kirilowii Maxim, 9-11 parts of poria cocos, 20-30 parts of corn stigma, 5-9 parts of donkey-hide gelatin, 5-6 parts of rhizoma bletillae, 9-18 parts of oyster, 9-15 parts of clam shell and 6-9 parts of platycodon grandiflorum.

5. The pharmaceutical composition for treating lung cancer according to claim 4, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: the traditional Chinese medicine composition comprises, by weight, 4 parts of American ginseng, 9 parts of radix bupleuri, 4 parts of flos Pruni mume, 19 parts of trichosanthes kirilowii Maxim, 11 parts of poria cocos, 20 parts of corn stigma, 6 parts of donkey-hide gelatin, 5 parts of rhizoma bletillae, 17 parts of oyster, 10 parts of clam shell and 7 parts of platycodon grandiflorum.

6. The pharmaceutical composition for treating lung cancer according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-6 parts of American ginseng, 3-9 parts of radix bupleuri, 3-5 parts of flos Pruni mume, 9-20 parts of trichosanthes kirilowii Maxim, 9-15 parts of poria cocos, 60-90 parts of corn stigma, 3-9 parts of donkey-hide gelatin, 6-15 parts of rhizoma bletillae, 9-30 parts of oyster, 6-15 parts of clam shell and 3-9 parts of platycodon grandiflorum.

7. The pharmaceutical composition for treating lung cancer according to claim 6, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 3-5 parts of American ginseng, 3-6 parts of radix bupleuri, 4-5 parts of flos Pruni mume, 9-14 parts of trichosanthes kirilowii Maxim, 11-15 parts of poria cocos, 70-80 parts of corn stigma, 3-6 parts of donkey-hide gelatin, 8-12 parts of rhizoma bletillae, 19-30 parts of oyster, 6-8 parts of clam shell and 3-5 parts of platycodon grandiflorum.

8. The pharmaceutical composition for treating lung cancer according to claim 7, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 5 parts of American ginseng, 4 parts of radix bupleuri, 5 parts of flos Pruni mume, 10 parts of trichosanthes kirilowii Maxim, 15 parts of poria cocos, 75 parts of corn stigma, 3 parts of donkey-hide gelatin, 12 parts of rhizoma bletillae, 28 parts of oyster, 6 parts of sea clam shell and 4 parts of platycodon grandiflorum.

9. The pharmaceutical composition for treating lung cancer according to claim 1, wherein: the pharmaceutical composition is prepared from the following raw materials in parts by weight: 6 parts of American ginseng, 8 parts of radix bupleuri, 3 parts of flos Pruni mume, 16 parts of trichosanthes kirilowii Maxim, 10 parts of poria cocos, 50 parts of corn stigma, 8 parts of donkey-hide gelatin, 6 parts of rhizoma bletillae, 10 parts of oyster, 13 parts of sea clam shell and 6 parts of platycodon grandiflorum.

10. Use of a pharmaceutical composition according to any one of claims 1 to 9 for the preparation of a pharmaceutical composition for the treatment of lung cancer.