CN103191203A - Medicine for treatment of cancer intestinal obstruction and preparation method thereof - Google Patents
Medicine for treatment of cancer intestinal obstruction and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a medicine for treatment of cancer intestinal obstruction and a preparation method thereof. The medicine comprises the following components by weight: 30-90 parts of clove, 10-30 parts of cinnamon, 10-40 parts of raw rhubarb, 6-12 parts of borneol, and 20-40 parts of mirabilite. The present invention has the advantages that: through external application of the invention, the medicine has the effects of tonifying spleen and warming the middle, moving qi and directing qi downward, promoting digestion and removing food retention, clearing away heat and relaxing the bowel, relieving swelling and pain, resolving hard lump, and removing stagnate and inducing menstruation; can release intestinal adhesion, increase gastrointestinal motility, improve intestinal blood circulation, reduce capillary permeability, protect the intestinal mucosal barrier and reduce bacterial translocation, promote inflammation edema recession, and inhibit the growth of enteric bacilli, and finally achieve the functions of promoting fart and cacation, diminishing inflammation and swelling, relieving abdominal distension and pain, and restoring gastrointestinal function. Proved by clinical application, the medicine has remarkable clinical efficacy, is easy, economical and safe to use, is high in patient compliance and is worthy of promotion.
Description
Technical field
The present invention relates to a kind of ileac medicine of tumor and preparation method thereof for the treatment of.
Background technology
Intestinal obstruction belongs to Chinese medicine categories such as " intestinal knots ", and its mechanism is that weakened body resistance wet stasis of blood poison pents up, and FU QI being obstructed makes the taste abnormal ascending-descending of QI, and stomach-QI being unable to descend normally, spleen lose the lucid yang sending up and show as pain, vomit, expand, close symptom.Treatment is usefulness with " leading to ", but should not be limited to " leading to ".The ileac external application side of existing treatment tumor compatibility is single: some uses Radix Et Rhizoma Rhei, Natrii Sulfas, and does not cooperate Flos Caryophylli, Cortex Cinnamomi; Some uses Flos Caryophylli, and does not have reasonable compatibility catharsis medicine; Some uses Flos Caryophylli, and without Cortex Cinnamomi.Relation between therefore existing method can not well be coordinated to attack and mend, the clinical scope of application is narrower, and clinical efficacy also has much room for improvement.
Summary of the invention
For overcoming the defective of prior art, the invention provides a kind of ileac medicine of tumor and preparation method thereof for the treatment of.Technical scheme of the present invention is: a kind of ileac medicine of tumor for the treatment of comprises that each component of following weight portion is formed: Flos Caryophylli 30-90 part, Cortex Cinnamomi 10-30 part, Radix Et Rhizoma Rhei 10-40 part, Borneolum Syntheticum 6-12 part, Natrii Sulfas 20-40 part.
60 parts of described Flos Caryophyllis, 20 parts of Cortex Cinnamomis, 30 parts of Radix Et Rhizoma Rhei, 8 parts of Borneolum Syntheticums, 30 parts in Natrii Sulfas.
A kind of preparation method for preparing the ileac medicine of described treatment tumor may further comprise the steps:
(1), takes by weighing each component according to weight portion;
(2), each component is mixed, be ground into fine powder, namely;
The granule size of described fine powder is 60～200 orders.
Being described below of each component:
Flos Caryophylli: acrid in the mouth, warm in nature, return spleen, stomach, kidney channel, have the effect of warming middle-JIAO to send down the adverse QI, warming the kidney to activate YANG, treatment singultus, coldness and pain in the epigastrium, the acid of waist knee joint are cold, sexual impotence, carbuncle of yin nature etc.Modern pharmacological research, Flos Caryophylli can stimulate intestinal wall, promote gastrointestinal peristalsis, discharge enteral holds unusually and stays gas, and effects such as antibiotic, antiinflammatory, anthelmintic are arranged simultaneously.
Cortex Cinnamomi: Xin Wen; there is the fire of benefit supporing yang; let the fire back to its origin; dispersing cold for relieving pain; the effect of promoting blood circulation to restore menstrual flow, cure mainly that sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, cold womb are infertile, dysmenorrhea, aversion to cold and cold limbs, soreness of the waist and knees, dizziness and tinnitus, impotence and seminal emission, dysuria or frequency, the dyspnea with rapid and short breath of losing heart, edema oliguria, floating YANG, refusing yang, flushed complexion cold foot, dispute rotten broken, coldness and pain in the epigastrium, decreased food intake loose stool, arthralgia due to cold-dampnes, carbuncle of yin nature multiple abscess, carbuncle and ulcer difficulty in discharging of pus or burst after do not hold back etc.Modern study proof Cortex Cinnamomi has digestion promoting function, and the stimulation of mitigation also can directly be arranged gastric mucosa, and secretion is increased, and gastric peristalsis strengthens. and can promote bowel movement, make the intestinal tube excitement.Oleum Cinnamomi has powerful bactericidal action, and is better to the effect of gram positive bacteria, and external application can be treated for stomachache, flatulence angor, and fungus is had powerful inhibitory action.
Natrii Sulfas: arduous little salty wet, return stomach, large intestine channel, the effect of purging heat to relax the bowels, clearing heat for detumescence, relaxing the bowels with lubricant drugs softening the hard mass is arranged, can all stasis of bloods of Tonghua stagnate, the treatment excess-heat is stagnant, abdominal distention constipation, retention of phlegm gather, mouthful red hide from view, erysipelas, carbuncle etc.The Natrii Sulfas main component is aqueous sulfuric acid sodium and small amount of chloride, calcium sulfate etc.Slowly absorb by skin after Natrii Sulfas external application abdominal part, medicine are heated, make medicine from outward appearance to inner essence, outside the through intestinal.Absorb characteristics such as moisture and osmotic pressure because of Natrii Sulfas self, can reduce capillary permeability, eliminate the intestinal wall edema, the Natrii Sulfas of external simultaneously can make the distribution of gastric antrum, colon near-end myenteric nerve plexus SP obviously increase, thereby neuronic irritability in the enhancing gastrointestinal wall, promote gastrointestinal peristalsis, increase hypertrophy phenomenon and the phagocytic function of reticuloendothelial system, strengthen the anti-infectious function of body; Can make local vascular dilation after the Natrii Sulfas external, blood flow is accelerated, and improves microcirculation, accelerates lymphocyte and generates, thereby transfer the resistance against diseases of body, accelerate absorption and the dissipation of inflammation, analgesic activity is arranged, finally reach exhaust defecation, eliminate abdominal distention, promote the purpose of restoration of gastrointestinal function.
Radix Et Rhizoma Rhei: bitter cold has the effect of heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, the constipation for the treatment of excess-heat, stagnation of QI due to dyspepsia, abdominalgia with intestinal abscess, not well, the conjunctival congestion pharyngeal swelling of dysentery, upper gastrointestinal hemorrhage etc.Modern study shows its contained associativity Radix Et Rhizoma Rhei acid, can stimulate big intestinal wall to cause that intestinal tube shrinks, secretion increases, and big intestinal contents is discharged easily, thereby reach the relieving constipation by purgation effect.Simultaneously Radix Et Rhizoma Rhei have remove sphincterismus, anticoagulant, antithrombotic, improve the gastrointestinal mucosa blood perfusion, the effect of protection gastrointestinal mucosa, bacteria growing inhibiting, reduction blood viscosity and erythrocyte aggregation, inhibition macrophage excessive activation and neutrophil infiltration, releases of minimizing inflammatory factor, anti-superoxide anion, removing oxygen-derived free radicals; in addition MDA is also had obvious inhibitory action, and inhibitory action there is tangible dose-effect relationship.
Borneolum Syntheticum: acrid in the mouth, hardship, cold nature has logical all keys, the stagnated fire of loosing, removing nebula make eye bright, the effect of reducing swelling and alleviating pain, closes in treatment calentura coma, the expectorant heat, infantile convulsion, conjunctival congestion and swelling pain, skin infection swell and ache etc.Modern study shows that Borneolum Syntheticum has effects such as antiinflammatory, antibiotic, calmness and analgesia.This place adds a small amount of Borneolum Syntheticum, and emphasis helps to drive the efficacy of a drug and reaches skin and corresponding acupuncture point thoroughly with the property of its hot volatilization of loosing, and improves drug effect.
Advantage of the present invention is: by external application medicine of the present invention; has the spleen invigorating warming middle-JIAO; activating qi for lowering adverse qi; consumer product dredge stasis; purging heat to relax the bowels; reducing swelling and alleviating pain; hard masses softening and resolving; the effect of eliminating blood stasis and inducing menstruation; the intestinal adhesion of can loosening; increase gastrointestinal peristalsis; improve the intestinal blood circulation; reduce capillary permeability; protect gut barrier and reduce the antibacterial displacement; promote the inflammation edema extinction; and can suppress the enterobacteria growth; finally reach the promotion aerofluxus; defecation; anti-inflammation detumescence; alleviate abdominal distention stomachache; recover the effect of gastrointestinal function; remarkable through clinical proof clinical efficacy of the present invention; easy to use; economical; safety; the patient compliance height is worth clinical expansion.
The specific embodiment:
The present invention treats ileac further the improvement at us to form on the basis of proved recipe, treat 8 routine tumor intestinal obstruction patients in the recent period, 7 example successes have 1 routine patient just to give treatment to hospital for gynecologic malignant tumor postoperative ileus March is surplus, lose treatment opportunity and fail.
Case 1:
Patient Zhang, the woman, 46 years old, the Hok-lo went to a doctor because of " upper right abdomen dull pain uncomfortable 1 year surplus, increase the weight of January " on May 28th, 2011.Upper right abdomen dull pain discomfort in February, 2010 appears in the patient, looks into CT in local hospital and finds liver's tumor, and in row on February 6th, 2010 " hepatocarcinoma tumorectomy ", postoperative pathology shows: middle differentiated hepatocellular cancer.Postoperative is still felt upper right abdomen dull pain discomfort, and it is invalid to take the Chinese medicine conditioning and treating, and conscious pain before increases the weight of, spiritlessness and weakness, and nausea and vomiting, anorexia, uneasy sleeping at night satisfy to go to a doctor.On June 1st, 2011, through several days the treatment symptom obvious alleviation is not arranged, defecate four days not the solution, cleansing enema is only seen weak yellow liquid, does not see feces, abdominal distention unbearably, red tongue with yellow fur, stringy and thready pulse.Advise to give external application of Chinese medicine SHENQUE acupoint, method is as follows:
(1) takes by weighing Flos Caryophylli 60g, Cortex Cinnamomi 20g, Radix Et Rhizoma Rhei 30g, Borneolum Syntheticum 8g, Natrii Sulfas 30g, with its mixing, be ground into fine powder (granularity is 60～200 orders); (2) get it filled powder and an amount of Bulbus Allii (mixed proportion of medicated powder and Bulbus Allii is 3:1) with smashing, utilize Bulbus Allii juice that medicated powder is made the medicine cake, medicine cake diameter is about 15cm, and the medicine cake is spread on patient's SHENQUE acupoint; (3) get Sal 1000g and pack in the cloth bag, and with meagre stove heating, the Sal bag after the heating is placed on the medicine cake that has applied, treat that Sal bag cooling back continues the heating use.
After patient's application compress, get rid of a little stool the morning, but still feel that constipation with dry stool is difficult to resolve, doctor's advice continues to give this law external application, and it is unobstructed gradually to defecate, day delegation, and intestinal obstruction is cured.
Case 2:
Patient Liu so-and-so, the man, 50 years old, Shandong Pingdu people was because " chest pain half a year accompany dry cough surplus January " intends " the multiple transfer of left pulmonary carcinoma " in income institute on November 02nd, 2012 by outpatient service.
The patient chest pain occurs in the beginning in May, 2012, and idol has uncomfortable in chest, and is nervous, JIUYUE in 2012 patient on the 11st looks into breast CT to the Pingdu City the People's Hospital: 1. meet LC type pulmonary carcinoma and vertical phrenic lymph nodes transfer CT performance, 2. right lung bulla 3. hepatics cyst 4. liver anomalies are strengthened kitchen range, back row bronchoscope: small cell carcinoma, the oncocyte composition is few, the cytology: the small cell undifferentiated carcinoma cell, after look into the video picture of whole body bone: multiple metastatic tumor of bone sign (T4-5, L1.5, right side 3.9. aft rib, right side sacrum ilium, ilium, the bilateral acetabular bone, the right lateral thigh proximal bone), being diagnosed as the multiple bone of pulmonary carcinoma shifts, the patient refuses the row chemicotherapy, gives Chinese medicine, tramadol hydrochloride 0.1q12h, norcantharidin 10mgtid treatment, poor effect, paroxysmal dry cough, no expectorant appear in the beginning before January, modern for asking Chinese medicine, the spy comes my institute to see a doctor, and inscribes: spiritlessness and weakness, dry cough without phlegm, chest pain is uncomfortable in chest, back and lumbus sacrum pain very then influence nighttime sleep, anorexia, the time have nauseating, stool 3-5 day delegation, matter is dried to be difficult to resolve, and urine is still transferred.The body of the tongue lining is purple, the little Huang of thin fur, stringy pulse.Have surplus the smoking history ten year, about 20/day, guard against January.AD left side pulmonary carcinoma is accompanied multiple transfer, carries out associated treatment.
On November 3rd, 2012, the patient was admitted to hospital second day, spiritlessness and weakness, dry cough without phlegm, chest pain is uncomfortable in chest, back and lumbus sacrum pain very then influence nighttime sleep, anorexia, the time have nauseating.The body of the tongue lining is purple, the little Huang of thin fur, stringy pulse.Look into the X line: left side pulmonary carcinoma, infull property intestinal obstruction.
On November 4th, 2012, the patient told abdominal distention and pain, did not have the gas of arrow, and stool is not separated today, and urine is still transferred.The body of the tongue lining is purple, the little Huang of thin fur, stringy pulse.The patient is 13:00 sense at noon abdominal distention discomfort up to the present, and stool is not separated, and the present gives 0.9% sodium chloride 500ml cleansing enema and alleviates abdominal distention, but DeGrain, so add lactulose oral solution 10mltid loosening bowel to relieve constipation, do not have stool to get rid of behind the clothes yet, 19:00 sense at night abdominal distention gives external application of Chinese medicine SHENQUE acupoint unbearably, preparation method is as follows: get Flos Caryophylli 30g, Cortex Cinnamomi 10g, Radix Et Rhizoma Rhei 10g, Borneolum Syntheticum 6g, Natrii Sulfas 20g, with its mixing, be ground into fine powder, using method is with case 1.Discharge stool night, abdominal distention stomachache is obviously alleviated.The back was continued the external application of Chinese medicine in several days, and intestinal obstruction obtains curing, and patient's abdominal distention stomachache disappears.
Case 3:
Patient Zhu, the woman, 66 years old, people from Zhangjiagang was because " stomachache is surplus half a year " intends " intestinal cancer hepatic metastases " in income institute on November 17th, 2012 by outpatient service.
Right side stomachache in April, 2012 appears in the patient, looks into CT to Zhangjagang City institute of traditional Chinese medicine and shows: 1, right side iliac fossa place occupying lesion, consider low level colon, hepatic region cancer possibility greatly, and companion's peripheral lymph node is big by 2 slightly, the right lobe of liver tuberosity shifts and do not get rid of.Further look into the intestinal mirror: ascending colon ulcer type Ca companion is not blocked the multiple polyp of colon, pathology: adenocarcinoma entirely.In on May 13rd, 2012 First People's Hospital, Zhangjagang City row " right lobe of liver partly excises+radical-ability right hemicolectomy+intraperitoneal drainage+otch drainage ", postoperative pathology: differentiation adenocarcinoma in (right hemicolon), the ulcer type, cancerous protuberance is soaked into the intestinal wall holostrome, to basic unit's outer fiber fatty tissue, and the formation cancerous node, omentum majus is seen the metastatic carcinoma tuberosity, (right liver) adenocarcinoma metastatic.The capable FORFIRI scheme chemotherapy of postoperative 3 times, because side reaction stops chemotherapy greatly, change the conditioning that takes traditional Chinese medicine, do during stomachache, on October 18th, 2012 looked into CT and shows: 1, change 2 behind the ascending colon cancer right hemicolectomy, the right front leaf of the liver outside is shifted the eminectomy postoperative and is changed, the other tuberosity of right front leaf portal vein shifts, more preceding increase, hypomere is newly seen a tuberosity metastasis 3 behind the right lobe of liver, fatty liver 4, bilateral kidney microlith, left side cyst of kidney, both sides adrenal gland's tuberosity is more preceding similar, shift and do not get rid of 5, the inferior lobe of left lung pulmonary belb, middle lobe of right lung and lingual segment of upper lobe of left lung strip of sheet shadow are more preceding similar, consider that fibrosis changes 6, a small amount of pelvic hydrops.On October 27th, 2012, the patient went to a doctor to the court, gave treatment by Chinese herbs, and it is not smooth to occur stool within the next few days, look into X sheet prompting intestinal obstruction, the present examines, and is further treatment income institute, inscribe: spiritlessness and weakness, stomachache, abdominal distention, constipation with dry stool is difficult to walk, arrow gas is few; urine is transferred, and sleeps generally red tip of the tongue night; tongue is greasy in vain, thready and weak pulse.Physical examination epigastrium can be laid one's hand on and visible peristalsis visible intestinal peristalsis, shifting dullness feminine gender, bowel sound hyperaction, about 4 times/minute.AD is: behind the intestinal cancer hepatic metastases postoperative chemotherapy, intestinal obstruction.
Through associated treatment two days later, the patient still feels spiritlessness and weakness, stomachache, abdominal distention, and constipation with dry stool is difficult to walk, and vows that gas is few, and urine is transferred, sleeps night generally, red tip of the tongue, tongue is greasy in vain, thready and weak pulse.Then give the external application of Chinese medicine on November 19th, 2012, get Flos Caryophylli 90g, Cortex Cinnamomi 30g, Radix Et Rhizoma Rhei 40g, Borneolum Syntheticum 12g, Natrii Sulfas 40g, with its mixing, be ground into fine powder, using method is with case 1, and November 20, the patient told the more preceding improvement of abdominal distention, but stool is dry and hard being difficult to resolve still, and arrow gas is arranged.Continue external application for curing, patient on the 21st tells when the abdominal distention pain is admitted to hospital and is clearly better, and the food of receiving increases, and vows that gas is many.Look into the X line: upright position plain abdominal radiograph no abnormality seen, patient's disease close friend changes, and is left hospital.
Claims (3)
1. the ileac medicine for the treatment of tumor is characterized in that, comprises that each component of following weight portion is formed: Flos Caryophylli 30-90 part, Cortex Cinnamomi 10-30 part, Radix Et Rhizoma Rhei 10-40 part, Borneolum Syntheticum 6-12 part, Natrii Sulfas 20-40 part.
2. the ileac medicine for the treatment of tumor according to claim 1 is characterized in that, 60 parts of described Flos Caryophyllis, 20 parts of Cortex Cinnamomis, 30 parts of Radix Et Rhizoma Rhei, 8 parts of Borneolum Syntheticums, 30 parts in Natrii Sulfas.
3. a preparation method for preparing claim 1 or the ileac medicine of 2 described treatment tumors is characterized in that, may further comprise the steps:
(1), takes by weighing each component according to weight portion;
(2), each component is mixed, be ground into fine powder, namely;
The granule size of described fine powder is 60～200 orders.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030975A (en) * | 2015-08-18 | 2015-11-11 | 重庆市中药研究院 | Medicine for treating adhesive intestinal obstruction and preparation method thereof |
| CN108403891A (en) * | 2018-05-11 | 2018-08-17 | 南充市中心医院 | Chinese medicine composition for treating abdominal post-operation Early selection sticks and its production method |
| CN108671051A (en) * | 2018-08-14 | 2018-10-19 | 上海市第七人民医院 | A kind of the outer of gout for the treatment of controls Chinese medicine composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785850A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional combination and preparation method thereof for intestinal obstruction treatment |
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2013
- 2013-03-14 CN CN201310080065.7A patent/CN103191203B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785850A (en) * | 2010-02-28 | 2010-07-28 | 泰一和浦（北京）中医药研究院有限公司 | Traditional combination and preparation method thereof for intestinal obstruction treatment |
Non-Patent Citations (2)
| Title |
|---|
| 李君久等: "中药外敷治疗粘连性肠梗阻临床疗效分析", 《中国医学工程》, vol. 13, no. 01, 28 February 2005 (2005-02-28) * |
| 李夏鲁: "大肠癌致低位肠梗阻临床治疗进展", 《中国医师进修杂志》, vol. 29, no. 17, 30 June 2006 (2006-06-30), pages 75 - 77 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030975A (en) * | 2015-08-18 | 2015-11-11 | 重庆市中药研究院 | Medicine for treating adhesive intestinal obstruction and preparation method thereof |
| CN108403891A (en) * | 2018-05-11 | 2018-08-17 | 南充市中心医院 | Chinese medicine composition for treating abdominal post-operation Early selection sticks and its production method |
| CN108671051A (en) * | 2018-08-14 | 2018-10-19 | 上海市第七人民医院 | A kind of the outer of gout for the treatment of controls Chinese medicine composition |
| CN108671051B (en) * | 2018-08-14 | 2021-03-09 | 上海市第七人民医院 | External-treatment traditional Chinese medicine composition for treating gout |
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