CN104547926B - A kind of soft capsule for treating chronic appendages inflammation and preparation method thereof - Google Patents
A kind of soft capsule for treating chronic appendages inflammation and preparation method thereof Download PDFInfo
- Publication number
- CN104547926B CN104547926B CN201510004967.1A CN201510004967A CN104547926B CN 104547926 B CN104547926 B CN 104547926B CN 201510004967 A CN201510004967 A CN 201510004967A CN 104547926 B CN104547926 B CN 104547926B
- Authority
- CN
- China
- Prior art keywords
- parts
- soft capsule
- radix
- seed
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 67
- 230000001684 chronic effect Effects 0.000 title claims abstract description 39
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 37
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 24
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 24
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 24
- 239000004863 Frankincense Substances 0.000 claims abstract description 24
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 24
- 240000008027 Akebia quinata Species 0.000 claims abstract description 23
- 235000007756 Akebia quinata Nutrition 0.000 claims abstract description 23
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 23
- 241001517299 Bulbophyllum Species 0.000 claims abstract description 23
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 23
- 241000675108 Citrus tangerina Species 0.000 claims abstract description 23
- 241001563035 Clinopodium polycephalum Species 0.000 claims abstract description 23
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 23
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 23
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 23
- 235000008434 ginseng Nutrition 0.000 claims abstract description 23
- 210000000582 semen Anatomy 0.000 claims abstract description 23
- 235000008671 Calycanthus floridus Nutrition 0.000 claims abstract description 22
- 235000008670 Calycanthus occidentalis Nutrition 0.000 claims abstract description 22
- 244000077995 Coix lacryma jobi Species 0.000 claims abstract description 22
- 241000218176 Corydalis Species 0.000 claims abstract description 22
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 22
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 22
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 22
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 22
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 22
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 22
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 22
- 240000000171 Crataegus monogyna Species 0.000 claims abstract description 22
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 22
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 22
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 22
- 239000009636 Huang Qi Substances 0.000 claims abstract description 22
- 235000004520 Lindera benzoin Nutrition 0.000 claims abstract description 22
- 235000008262 Lindera benzoin var. benzoin Nutrition 0.000 claims abstract description 22
- 210000002826 placenta Anatomy 0.000 claims abstract description 22
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 16
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 15
- 244000164480 Curcuma aromatica Species 0.000 claims abstract description 15
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 15
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 15
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 15
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 15
- 239000004480 active ingredient Substances 0.000 claims abstract description 12
- 238000000227 grinding Methods 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 238000001914 filtration Methods 0.000 claims description 27
- 235000019441 ethanol Nutrition 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 24
- 240000004371 Panax ginseng Species 0.000 claims description 22
- 244000025311 Calycanthus occidentalis Species 0.000 claims description 21
- 239000000284 extract Substances 0.000 claims description 21
- 241000207925 Leonurus Species 0.000 claims description 20
- 241000411851 herbal medicine Species 0.000 claims description 17
- 239000011812 mixed powder Substances 0.000 claims description 17
- 239000000725 suspension Substances 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- 239000000706 filtrate Substances 0.000 claims description 15
- 235000013871 bee wax Nutrition 0.000 claims description 9
- 239000012166 beeswax Substances 0.000 claims description 9
- 239000000499 gel Substances 0.000 claims description 9
- 235000008390 olive oil Nutrition 0.000 claims description 9
- 239000004006 olive oil Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 238000012216 screening Methods 0.000 claims description 8
- 238000005303 weighing Methods 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 7
- 108010010803 Gelatin Proteins 0.000 claims description 6
- 239000008273 gelatin Substances 0.000 claims description 6
- 229920000159 gelatin Polymers 0.000 claims description 6
- 235000019322 gelatine Nutrition 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- 239000003981 vehicle Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 2
- 240000002853 Nelumbo nucifera Species 0.000 claims 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 41
- 210000004369 blood Anatomy 0.000 abstract description 29
- 239000008280 blood Substances 0.000 abstract description 29
- 230000000694 effects Effects 0.000 abstract description 25
- 230000001737 promoting effect Effects 0.000 abstract description 22
- 239000003814 drug Substances 0.000 abstract description 10
- 230000004087 circulation Effects 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 7
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 5
- 230000003213 activating effect Effects 0.000 abstract description 4
- 240000007890 Leonurus cardiaca Species 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 244000148992 Lindera benzoin Species 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 description 16
- 210000004072 lung Anatomy 0.000 description 14
- 208000014674 injury Diseases 0.000 description 12
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 208000004998 Abdominal Pain Diseases 0.000 description 10
- 206010062717 Increased upper airway secretion Diseases 0.000 description 10
- 206010049677 Salpingo-oophoritis Diseases 0.000 description 10
- 210000001015 abdomen Anatomy 0.000 description 10
- 208000026435 phlegm Diseases 0.000 description 10
- 206010011224 Cough Diseases 0.000 description 9
- 230000000202 analgesic effect Effects 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 230000008736 traumatic injury Effects 0.000 description 8
- 244000178320 Vaccaria pyramidata Species 0.000 description 7
- 235000010587 Vaccaria pyramidata Nutrition 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 7
- 230000001939 inductive effect Effects 0.000 description 7
- 230000008961 swelling Effects 0.000 description 7
- 206010012735 Diarrhoea Diseases 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 6
- 208000004880 Polyuria Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000035619 diuresis Effects 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 208000006820 Arthralgia Diseases 0.000 description 5
- 206010037660 Pyrexia Diseases 0.000 description 5
- 210000000038 chest Anatomy 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 206010013975 Dyspnoeas Diseases 0.000 description 4
- 208000012287 Prolapse Diseases 0.000 description 4
- 241000270295 Serpentes Species 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 230000005906 menstruation Effects 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 3
- 206010001928 Amenorrhoea Diseases 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010013935 Dysmenorrhoea Diseases 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 241001480037 Microsporum Species 0.000 description 3
- 206010044565 Tremor Diseases 0.000 description 3
- 206010046788 Uterine haemorrhage Diseases 0.000 description 3
- 206010000269 abscess Diseases 0.000 description 3
- 231100000540 amenorrhea Toxicity 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 238000002651 drug therapy Methods 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 208000006750 hematuria Diseases 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 201000005630 leukorrhea Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000004396 mastitis Diseases 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 210000001672 ovary Anatomy 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 206010046901 vaginal discharge Diseases 0.000 description 3
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000003014 Bites and Stings Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010049077 Hernia pain Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 241000405414 Rehmannia Species 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 206010000210 abortion Diseases 0.000 description 2
- 206010003246 arthritis Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 208000013219 diaphoresis Diseases 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 230000003821 menstrual periods Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001114 myogenic effect Effects 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010000242 Abortion threatened Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010003402 Arthropod sting Diseases 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 244000296102 Selinum monnieri Species 0.000 description 1
- 235000019084 Selinum monnieri Nutrition 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 208000005985 Threatened Abortion Diseases 0.000 description 1
- 241001502500 Trichomonadida Species 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 229960004099 azithromycin Drugs 0.000 description 1
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001269 cardiogenic effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 201000003511 ectopic pregnancy Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 201000010063 epididymitis Diseases 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 206010019847 hepatosplenomegaly Diseases 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 229940074869 marquis Drugs 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 208000010553 multiple abscesses Diseases 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 208000005963 oophoritis Diseases 0.000 description 1
- 201000005737 orchitis Diseases 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- VBUNOIXRZNJNAD-UHFFFAOYSA-N ponazuril Chemical compound CC1=CC(N2C(N(C)C(=O)NC2=O)=O)=CC=C1OC1=CC=C(S(=O)(=O)C(F)(F)F)C=C1 VBUNOIXRZNJNAD-UHFFFAOYSA-N 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 201000010727 rectal prolapse Diseases 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of soft capsule for treating chronic appendages inflammation and preparation method thereof, the active ingredient and its mass fraction that soft capsule is made are：10 30 parts of motherwort, 5 20 parts of radix bupleuri, 3 18 parts of peach kernel, 5 15 parts of semen brassicae, 10 20 parts of decumbent corydalis tuber, 5 15 parts of Radix Astragali, 3 20 parts of Bulbophyllum calodictyon schlecht, 2 18 parts of akebi, 5 15 parts of Radix Rehmanniae, 4 16 parts of frutus cnidii, 2 20 parts of the root of three-nerved spicebush, 5 15 parts of frankincense, 10 30 parts of Radix zanthoxyli, 10 30 parts of ginseng, 2 20 parts of tangerine seed, 2 20 parts of Hex godajam (colebr) Wall, 4 16 parts of curcuma zedoary, 5 25 parts of coix seed, 5 15 parts of dried human placenta, 4 20 parts of clinopodium polycephalum, 5 20 parts of hawthorn, extracted, decoction, ultramicro grinding, spray drying, compacting and be made.Raw material selected by the present invention is all traditional Chinese medicine material, it is without side-effects, the effect of meeting traditional Chinese medicine and pharmacy and modern medical theory, complement each other using, effectively playing its antibacterial anti-inflammatory, alleviating pain and detumescence, promoting the circulation of qi dissipating bind, activating blood and eliminatng dampness, it is significant in efficacy, short treating period, quick, non-relapse after healing, securely and reliably, it has no toxic side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, are related to a kind of soft capsule for treating chronic appendages inflammation and preparation method thereof.
Background technology
Fallopian tubal, ovary in internal genital organs of female are referred to as adnexa uteria.Adnexitis refers to fallopian tubal and ovary
Inflammation is that pathogenic microorganisms invades the common disease for fallopian tubal, ovary being caused to infect after reproductive organs.Adnexitis be divided into it is acute and
Chronic two kinds.Chronic appendages inflammation refers to internal genital organs of female, including uterus, fallopian tubal, ovary and surrounding connective tissue,
The general name of inflammation during chronic or unresolved infection occurs for pelvic peritoneum etc..Chronic appendages inflammation mostly occurs in postpartum, Cesarean esction
Afterwards, post-abortion, various gynecologic surgeries and after intrauterine device is placed, at this moment the integrality of reproductive organs and its from
Right defence has damage, and bacterium is made to get enter into the surface of a wound, is allowed to infect and fall ill.
Chronic appendages inflammation shows as different degrees of abdominal pain, chronic inflammation recurrent exerbation, with the passing of time delay, fills pelvic cavity
Blood, connective fiber, pelvic organ stick to each other.There is lower abdomen falling inflation, pain and waist sacrum and the symptoms such as aches in patient, when
Weight when light, and with leucorrhea increasing, Low Back Pain, menstrual disorder etc., and often in menstrual period or tired postemphasis.Bilateral during gynecologial examination
Or unilateral attachment area tenderness, have to thicken and feel or occur the mass of tenderness, white blood cell count(WBC) increase or normal.
Chronic appendages inflammation is common disease, the frequently-occurring disease for perplexing women daily life, and often recurrent exerbation, obstinate,
Even cause symptoms and the moods such as soreness and weakness of waist and knees, irritable.At present, treatment chronic appendages inflammation is mainly using western medical treatment, west
For doctor mainly using the oral or intravenous administration of Conventional antibiotic, therapeutic effect is undesirable, and prolonged and repeated application antibiotic easily makes carefully
Bacterium generates drug resistance and causes suprainfection, and body is produced a very large impact.Need exploitation one kind that can take for long periods of time, it is right
Body has no adverse effects, and has additional nutrients and improves the Chinese medicine of immunity of organisms, and local edema is made to dissipate, scar softening, promotes intestines
It wriggles, promote blood circulation, treating both manifestation and root cause of disease makes local lesion obtain good improvement.
Invention content
Can be taken for a long time in view of the deficiencies of the prior art, it is an object of the present invention to provide one kind, treating both manifestation and root cause of disease, without pair make
With, the soft capsule and preparation method thereof for the treatment of chronic appendages inflammation that has additional nutrients and improve immunity of organisms.
Technical solution is used by the present invention solves the above problems：
The bulk pharmaceutical chemicals and its mass fraction of the active ingredient of soft capsule are made in a kind of soft capsule for treating chronic appendages inflammation
For：10-30 parts of motherwort, 5-20 parts of radix bupleuri, 3-18 parts of peach kernel, 5-15 parts of semen brassicae, 10-20 parts of decumbent corydalis tuber, 5-15 parts of Radix Astragali,
3-20 parts of Bulbophyllum calodictyon schlecht, 2-18 parts of akebi, 5-15 parts of Radix Rehmanniae, 4-16 parts of frutus cnidii, 2-20 parts of the root of three-nerved spicebush, 5-15 parts of frankincense, two
Needle 10-30 parts of face, 10-30 parts of ginseng, 2-20 parts of tangerine seed, 2-20 parts of Hex godajam (colebr) Wall, 4-16 parts of curcuma zedoary, 5-25 parts of coix seed, purple river
5-15 parts of vehicle, 4-20 parts of clinopodium polycephalum, 5-20 parts of hawthorn.
Further, the bulk pharmaceutical chemicals and its mass fraction that the active ingredient of soft capsule is made are：15-25 parts of motherwort, bavin
9-16 parts of Hu, 7-14 parts of peach kernel, 8-12 parts of semen brassicae, 12-18 parts of decumbent corydalis tuber, 8-12 parts of Radix Astragali, 8-15 parts of Bulbophyllum calodictyon schlecht, akebi 7-
13 parts, 8-12 parts of Radix Rehmanniae, 7-13 parts of frutus cnidii, 8-14 parts of the root of three-nerved spicebush, 8-12 parts of frankincense, 15-25 parts of Radix zanthoxyli, ginseng 15-
25 parts, 7-15 parts of tangerine seed, 7-15 parts of Hex godajam (colebr) Wall, 7-13 parts of curcuma zedoary, 10-20 parts of coix seed, 8-12 parts of dried human placenta, clinopodium polycephalum 9-15
Part, 10-15 parts of hawthorn.
Further, the bulk pharmaceutical chemicals and its mass fraction that the active ingredient of soft capsule is made are：20 parts of motherwort, radix bupleuri 12
Part, 11 parts of peach kernel, 10 parts of semen brassicae, 15 parts of decumbent corydalis tuber, 10 parts of Radix Astragali, 12 parts of Bulbophyllum calodictyon schlecht, 10 parts of akebi, 10 parts of Radix Rehmanniae, cnidium monnieri
10 parts of son, 11 parts of the root of three-nerved spicebush, 10 parts of frankincense, 20 parts of Radix zanthoxyli, 20 parts of ginseng, 11 parts of tangerine seed, 11 parts of Hex godajam (colebr) Wall, curcuma zedoary 10
Part, 15 parts of coix seed, 10 parts of dried human placenta, 12 parts of clinopodium polycephalum, 12 parts of hawthorn.
Pharmacological action：
Motherwort：Acrid flavour, hardship, property it is micro- into.Enter the heart, liver, bladder warp.Promoting blood circulation, dissolving stasis, menstruation regulating, disappear water.Control irregular menstruation,
Threatened abortion is had difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, and hematuria rushes down blood, carbuncle swells sore.Removing blood stasis for promoting tissue regeneration, and can
For traumatic injury, there is certain curative effect by damp and hot pelvic inflammation also for women；Radix bupleuri：Acrid flavour, hardship, cold nature.Return liver, courage,
Lung channel.In inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever.For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, menstruation
It is uncomfortable, the prolapse of uterus, rectal prolapse；Peach kernel：Promoting blood circulation relaxes bowel.For Amenorrhea, dysmenorrhoea , wei lump in the abdomen lump in the abdomens, injury from falling down, intestines
Dry constipation.The sweet flat, bitter of peach kernel, enters lung, liver, large intestine channel；There is the effect of blood-breaking row stasis of blood, moisturize laxation；Controlling through closing, dysmenorrhoea,
Lump in the abdomen lump in the abdomen lump in the abdomen, traumatic injury, dry constipation of intestines；Semen brassicae：It is odorless, it is acrid flavour, peppery.Enter meridian of Hand-TAI YIN.Warm lung slit phlegm profit gas, dissipating bind are led to
Network relieves pain.Reduces phlegm by drink；Mass dissipating and swelling eliminating.Main cough and phlegm, fullness in the chest and hypochondriac pain, extremity numbness, painful swelling of joints, multiple abscess with damp phlegm, cloudy subcutaneous ulcer
Pyogenic infections.Control acute mastitis, breast cancer, mammary gland pain, tuberculosis, phlegm and retained fluid cough and asthma, fullness in chest and hypochondrium pain, gastric disorder causing nausea vomiting, aphasia from apoplexy, limbs numbness
Pain is numb, tinea pedis, cloudy subcutaneous ulcer, pyogenic infections, treating swelling and pain by traumatic injury.For phlegm asthma cough of trembling with fear, distending pain in the chest and hypochondrium, the stagnant channels and collaterals of phlegm, joint numbness, pain,
Phlegm-damp oozing in the body, cloudy subcutaneous ulcer pyogenic infections；Decumbent corydalis tuber：Bitter, micro-pungent, it is warm-natured.Return liver warp.Have promoting blood circulation it is active, promoting qi circulation and relieving pain, dispelling wind and eliminating dampness has
Effect.For hemiplegia, headache, injury from falling down, arthralgia pain due to rheumatism, lumbocrural pain；Radix Astragali：It is sweet, tepor.Return lung, spleen, liver, kidney
Through.There is inducing diuresis for removing edema, detoxification, myogenic, suitable for spontaneous perspiration, night sweat, blood-arthralgia, edema, un-festering of ulcer or burst do not hold back long
Wait diseases.Preparing astragalus membranaceus has effect in tonifying Qi, blood-nourishing, benefit, suitable for diseases such as internal injury overstrain, splenasthenic diarrhea, the deficiency of vital energy, the deficiency of blood, laboured breathings；
Bulbophyllum calodictyon schlecht：Pungent, sweet and neutral.Enter lung, liver, kidney three to pass through.It moistens the lung and relieve the cough, anti-inflammatory analgetic, reunion of fractured tendons and bones.For pulmonary tuberculosis cough, hemoptysis
Person.For acute mastitis, abscess of throat and sore swell and ache curative person.For spraining, traumatic injury fracture person；Akebi：Bitter, it is cold in nature.Return
The heart, small intestine, bladder warp.There are inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, under promoting menstruation the effect of breast.For stranguria, oedema, red, the dispute of vexed urine
Raw sore, Amenorrhea breast lack, damp and hot numbness pain；Radix Rehmanniae：It is sweet, it trembles with fear.The thoughts of returning home, liver, kidney channel.The existing anastalsis of glutinous rehmannia, and have anticoagulation work
With；Glutinous rehmannia flooding agent is to trichophyton mentagrophytes, gypsum sample microsporum, ulotrichy microsporum and microsporum audouini etc.
The growth of a variety of fungies has inhibiting effect；Frutus cnidii：It is warm-natured, bitter.Warming kidney and enhancing body, eliminating dampness, wind-dispelling, desinsection.For impotence, palace
Cold, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness pain in the back；Control eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis outside；The root of three-nerved spicebush：It is dredged with promoting the circulation of qi
The effect of liver, eliminating cold to stop pain.Cure mainly Liver Channel cold obstruction causing qi stagnation card.Herria, few abdomen draw control testis and pain, swelling and hanging down of either of the testes swelling or few
Abdomen pain, tongue is white, veins string.Clinic is usually used in the categories such as treatment orchitis, epididymitis, gastric and duodenal ulcer, chronic gastritis and trembles with fear
Solidifying stagnation of the circulation of vital energy person；Frankincense：It is arduous, temperature.Enter the heart, liver, the spleen channel.Regulating qi and activating blood, analgesic therapy chase after poison.Control qi and blood stagnation, trusted subordinate's pain, carbuncle
Pyogenic infections from tumour or sore, traumatic injury, dysmenorrhoea, postpartum blood stasis stabbing pain.There is more significant analgesic activity.The uterus ball ratio of taste medicine headed by frankincense
A variety of antibacterials are known as stronger strong bacteriostasis, and can effectively kill trichomonad；Radix zanthoxyli：It is bitter, pungent, it is mild-natured.Return liver, stomach
Through.It is promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dispelling wind and removing obstruction in the meridians, removing toxicity for detumescence.It for injury from falling down, has a stomachache, toothache, arthralgia pain due to rheumatism, poisonous snake stings
Wound, externally treating burns and scalds；Ginseng：Sweet in flavor, slight bitter, it is warm-natured, flat.Returns spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, prevent prolapse are promoted the production of body fluid, and are calmed the nerves, intelligence development.
Cure mainly it is physically weak to be taken off, cold weak pulse of limb, spleen eating less, the deficiency syndrome of the lung breathes with cough, and injury thirst, Heat Diabetes, prolonged illness void is thin, insomnia of palpitating with fear,
Impotence Gong Leng, heart failure are cardiogenic to stop part.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hidrosis, deficiency of food is powerless, all are anxious slow
Property disease and stop part, collapse caused by after losing blood.It reinforces vital energy, prevent prolapse and engender liquid is calmed the nerves.It is deficient to control internal lesion caused by overexertion, deficiency of food, burnout, instead
Stomach spits food, lingering diarrhea of defecating, cough of deficient and syndrome characterized by dyspnea, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, impotence, and frequent micturition is quenched one's thirst, woman uterine bleeding,
Infantile chronic fright and perennial and irrecoverable weakness, the card of all qi-blood-body fluid deficiencies；Tangerine seed：Bitter, it is mild-natured.Return liver and kidney channel.Qi-regulating, dissipating bind,
Analgesic.For hernia pain, testiclar gall, acute mastitis breast addiction；Hex godajam (colebr) Wall：It is cold in nature, bitter.Return lung, liver, large intestine channel.It is clearing heat and detoxicating,
Dampness removing relieves pain.For cold, fever, abscess of throat, stomachache, summer heat damp diarrhea, jaundice, dysentery, traumatic injury, arthralgia pain due to rheumatism, wet
Rash, boil；Curcuma zedoary：It is pungent, bitter, temperature.Return liver, the spleen channel.Blood-breaking, Xiao Ji Zhi Tong：For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate
Distending pain, accumulation, women's blood stasis, traumatic injury are had a pain eating accumulation；Promoting qi circulation and relieving pain, blood-breaking disperse accumulation：For qi depression to blood stasis it
Amenorrhea, chest and hypochondrium, abdominal pain and abdominal mass lump etc.；Promoting digestion and removing indigestion：For the stomach abdominal distention and pain of eating accumulation, often with melanoidin malt, burnt Bin
It is bulky；Coix seed：It is sweet in flavor, light, it is cool in nature.Returns spleen, stomach, lung channel.Advantageous water penetration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, detoxicating and resolving a mass
Effect.For oedema, tinea pedis, difficult urination, splenasthenic diarrhea, arthritis with fixed pain caused by dampness contraction, lung carbuncle, acute appendicitis, wart, cancerous swelling；Dried human placenta：Property
It is sweet in flavor, salty, warm, enter lung, the heart, kidney channel, there is tonifying kidney and benefiting sperm, the work(of nourishing qi and blood.Cure mainly deficient, thin thin, hemoptysis asthma, the hot bone of labor
The diseases such as steaming, seminal emission；Clinopodium polycephalum：It is slight bitter, puckery, it is cool.Return liver warp.Cure mainly anemopyretic cold, cough, red eye, swell pain, abscess of throat, white
Larynx, abdominal pain dysentery, haematemesis, spitting of blood, hematuria, uterine bleeding, traumatic hemorrhage, hepatitis, cholecystitis, narrow rib, stomachache, arthralgia, sore
Swollen, venomous snake bite, eczema, hemorrhoid, treating swelling and pain by traumatic injury.Clinical application：For uterine bleeding, hematuria, nosebleed epistaxis, bleeding gums, traumatic bleeding；
Hysteromyoma hemorrhage；Hawthorn：Sour sweet, tepor.Enter spleen, stomach, Liver Channel.Digestion gathered food, scattered blood stasis, expelling tenia.Control meat product, abdominal mass, phlegm
Drink, feeling of fullness, acid regurgitation, rush down dysentery, intestines wind, pain in the back, hernia postpartum postpartum abdominal pain, lochiorrhagia, pediatric milk food stagnation.Food digesting stomach fortifying, row
Gas dissipates the stasis of blood.For meat stagnation, gastric ulcer fullness, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain, height
Blood fat disease.
The present invention also provides a kind of preparation method for the soft capsule for treating chronic appendages inflammation, the preparation method includes following
Step：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
It after art, clinopodium polycephalum crush, is extracted 2 times with ethyl alcohol, the ethyl alcohol that the 6-8 times of mass concentration measured is 90% is added to extract 2-3 for the first time small
When, filtering, filter residue is for the second time plus the 4-6 times of mass concentration measured is extracted 1-2 hours for 80% ethyl alcohol, and filtering merges and filters twice
Liquid obtains extracting solution；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 1-2 hours with 5-7 times of water, filtering, filter residue is decocted 0.5-1 hours for the second time with 3-4 times of water, and filtering merges twice
Filtrate obtains decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：(1-1.04)：(0.5-0.52)：(0.5-
0.52) suspension is made, 1 is pressed with gelatin, glycerine, water：(0.3-0.5)：0.8 ratio prepares rubber, then fills suspension
Dress is pressed into soft capsule, washes away soft capsule appearance oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
Application method：It is oral, 3 times a day, each 1 time in the morning, afternoon and evening, 2 tablets each time, warm water delivery service after meal；10 days are 1 treatment
Journey, continuously takes the 2-4 course for the treatment of, and serious patient increases the amount of discretion.
It is provided by the invention treatment chronic appendages inflammation soft capsule in the treatment with blood stasis-eliminating and stagnation-dissipating, remove obstruction in channels to relieve pain, heat-clearing profit
Wet is the rules for the treatment of, and selected medicinal material compatibility is suitable, meets traditional Chinese medicine and pharmacy and modern medical theory.Motherwort promoting blood circulation, tune in side
Through the water that disappears, peach kernel promoting blood circulation relaxes bowel, and tangerine seed has the function of qi-regulating eliminating stagnation to stop pain, and the advantageous water penetration of coix seed is wet, is good for
The effect of spleen antidiarrheal, eliminating impediment, apocenosis, the effect of detoxicating and resolving a mass, blood stasis-eliminating and stagnation-dissipating is strengthened in four conjunctions 5；Semen brassicae warm lung slit phlegm profit
Gas, dissipating bind are removed obstruction in channels to relieve pain, and Bulbophyllum calodictyon schlecht moistens the lung and relieve the cough, anti-inflammatory analgetic, reunion of fractured tendons and bones, and frankincense regulating qi and activating blood, analgesic therapy chase after poison, Radix zanthoxyli
Promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, dispelling wind and removing obstruction in the meridians, removing toxicity for detumescence, curcuma zedoary blood-breaking, Xiao Ji Zhi Tong, more than five kinds of Chinese medicine, which shares, makes this
The effect of regulating qi and dredging collateral analgesic of invention, is further；In radix bupleuri energy and inducing diaphoresis, soothing liver-qi stagnation, yang invigorating, preventing malaria of bringing down a fever, Huang
Stilbene has effects that inducing diuresis for removing edema, detoxification, myogenic, and akebi has an inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, it is newborn under promoting menstruation the effect of, Hex godajam (colebr) Wall
Clearing heat and detoxicating, dampness removing analgesic, four, which close 5, is optimal the effect of clearing heat and promoting diuresis；More there is Radix Rehmanniae, frutus cnidii warming kidney and enhancing body, dry
Wet wind-dispelling, desinsection, ginseng qi-tonifying prevent prolapse, promoting production of body fluid and inducing sedation of the mind intelligence development, dried human placenta have the effect of tonifying kidney and benefiting sperm, nourishing qi and blood, clinopodium polycephalum
With antiinflammatory and bacteriostatic functions, all medicines share play altogether blood stasis-eliminating and stagnation-dissipating, remove obstruction in channels to relieve pain, clearing heat and promoting diuresis the effect of, righting is consolidated, in eliminating evil
Righting, eliminating evil in righting are mended and helpless, evil net eutopic reduction, the mutual compatibility of component, and each component acts on each pathology layer of adnexitis
Face, the whole various pathological changes for improving adnexitis treat chronic appendages inflammation purpose to reach.
Meanwhile the preparation method of the soft capsule of the treatment chronic appendages inflammation uses different processing for different medicinal materials
Method, the effect of making that its maximum can have been given play to per medicinal material simply, by Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax system
Make soft capsule into suspension, the disintegration rate of soft capsule is fast, make patient take the present invention soft capsule after, it is therein effectively into
Lesions position, quick release drug effect can be rapidly reached by dividing.
The beneficial effects of the invention are as follows：
(1) raw material selected by is all traditional Chinese medicine material, without side-effects, meets traditional Chinese medicine and pharmacy and modern medical theory；
(2) raw material selected by complements each other, so as to effectively play its antibacterial anti-inflammatory, analgesic through dialectical compatibility using
The effect of detumescence, promoting the circulation of qi dissipating bind, activating blood and eliminatng dampness；
(3) different medicinal materials uses different processing methods, the effect of making that its maximum can have been given play to per medicinal material simply, does
Into soft capsule, disintegration rate is fast, and after patient is made to take the soft capsule of the present invention, active ingredient therein can be rapidly reached lesion portion
Position, quick release drug effect；
(4) there is the effect of notable to treatment chronic appendages inflammation, short treating period is quick, non-relapse after healing, securely and reliably,
It has no toxic side effect, is worth promoting the use of in clinic.
The advantageous effect further illustrated the present invention with reference to clinical laboratory data.
(1) clinical data
Selected 279 patients, age 22-48 Sui, the course of disease -3 years 2 months.Patient is randomly divided into treatment group and control group.It controls
Treatment group 186, control group 93.Two groups of state of an illness are substantially similar, are comparable.
(2) diagnostic criteria
Have different degrees of abdominal pain, pain aggravates during pressing, underbelly falling inflation and involves sense, when it is light when weigh, filled with pelvic cavity
Blood, connective fiber, pelvic organ stick to each other, leucorrhea increasing, leukorrhea is in purulence or homogenieity mucus shape, menstrual disorder
Etc. symptoms.
(3) therapy
Drug of the present invention is taken by treatment group, takes orally, 3 times a day, each 1 time in the morning, afternoon and evening, and 2 tablets each time, warm water delivery service after meal；
10 days are 1 course for the treatment of, continuously take the 2-4 course for the treatment of, serious patient increases the amount of discretion.
Control group takes azithromycin capsule, takes orally, and 3 times a day, once two grains, warm water is swallowed or follows the doctor's advice before meals, treats
Journey is depending on the state of an illness.
(4) efficacy assessment standard
Recovery from illness：The clinical symptoms such as abdominal pain, abnormal leucorrhea and sign disappear, and gynaecology and ultrasound diagnosis are normal；
It is effective：Above-mentioned clinical symptoms and sign are substantially reduced, and gynaecology and ultrasound diagnosis have improvement；
It improves：Above-mentioned clinical symptoms and sign are mitigated, and gynaecology and ultrasound diagnosis have improvement；
In vain：Above-mentioned clinical symptoms are without being clearly better.
(5) treatment results
The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group.
(6) model case
Case 1：Tang, female, 28 years old.After production, the menstrual cycle is not bery normal always, and there are many leukorrhea, have a pain in the back, lower abdomen
Falling inflation, on inspection diagnosis have suffered from chronic appendages inflammation, had used a variety of drug therapies, and had no any improvement, recommend to take through doctor
With drug therapy of the present invention, after taking 2 course for the treatment of, symptom is improved, and is continued after taking 2 course for the treatment of, and symptom disappears, recovery from illness,
Follow-up is without recurrence after half a year.
Case 2：Marquis, female, 33 years old.Because of ectopic pregnancy post-abortion after marriage, lower abdomen secret anguish is with creeping chill, desire for warm and being pressed, waist
Sacrum is ached, and menstrual period are normal but few through measuring, and leukorrhea is more, and tongue is thin white, deep thready pulse.Through diagnosis with chronic appendages inflammation, this is taken
Invention drug therapy, after taking 1 course for the treatment of, symptom is substantially reduced, continues after taking 2 course for the treatment of, and symptom disappears, recovery from illness, follow-up
So far without recurrence.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme of the present invention is clearly and completely described.
Embodiment 1
A kind of soft capsule for treating adnexitis, the active ingredient and its quality that soft capsule is made are：10 parts of motherwort, radix bupleuri
5 parts, 3 parts of peach kernel, 5 parts of semen brassicae, 10 parts of decumbent corydalis tuber, 5 parts of Radix Astragali, 3 parts of Bulbophyllum calodictyon schlecht, 2 parts of akebi, 5 parts of Radix Rehmanniae, 4 parts of frutus cnidii,
2 parts of the root of three-nerved spicebush, 5 parts of frankincense, 10 parts of Radix zanthoxyli, 10 parts of ginseng, 2 parts of tangerine seed, 2 parts of Hex godajam (colebr) Wall, 4 parts of curcuma zedoary, 5 parts of coix seed,
5 parts of dried human placenta, 4 parts of clinopodium polycephalum, 5 parts of hawthorn.
The preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
It after art, clinopodium polycephalum crush, is extracted 2 times with ethyl alcohol, the ethyl alcohol that the mass concentrations for adding 6 times of amounts for the first time are 90% extracts 2 hours, mistake
Filter, the ethyl alcohol that the mass concentration of second plus 4 times amount of filter residue is 80% extract 1 hour, and filtering merges filtrate twice, carried
Take liquid；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 1 hour with 5 times of water, filtering, filter residue is decocted 0.5 hour for the second time with 3 times of water, and filtering merges filtrate twice, obtains
Decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：1：0.5：0.5 is made suspension, with gelatin,
Glycerine, water press 1：0.3：0.8 ratio prepares rubber, is then pressed into soft capsule by suspension is filling, washes away soft capsule appearance
Oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
Embodiment 2
A kind of soft capsule for treating adnexitis, the active ingredient and its quality that soft capsule is made are：30 parts of motherwort, radix bupleuri
20 parts, 18 parts of peach kernel, 15 parts of semen brassicae, 20 parts of decumbent corydalis tuber, 15 parts of Radix Astragali, 20 parts of Bulbophyllum calodictyon schlecht, 18 parts of akebi, 15 parts of Radix Rehmanniae, snake
16 parts of machine tool, 20 parts of the root of three-nerved spicebush, 15 parts of frankincense, 30 parts of Radix zanthoxyli, 30 parts of ginseng, 20 parts of tangerine seed, 20 parts of Hex godajam (colebr) Wall, curcuma zedoary 16
Part, 25 parts of coix seed, 15 parts of dried human placenta, 20 parts of clinopodium polycephalum, 20 parts of hawthorn.
The preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
It after art, clinopodium polycephalum crush, is extracted 2 times with ethyl alcohol, the ethyl alcohol that the mass concentrations for adding 8 times of amounts for the first time are 90% extracts 3 hours, mistake
Filter, the ethyl alcohol that the mass concentration of second plus 6 times amount of filter residue is 80% extract 2 hours, and filtering merges filtrate twice, carried
Take liquid；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 2 hours with 7 times of water, filtering, filter residue is decocted 1 hour for the second time with 4 times of water, and filtering merges filtrate twice, decocted
Boil liquid；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：1.02：0.52：0.5 is made suspension, with
Gelatin, glycerine, water press 1：0.5：0.8 ratio prepares rubber, is then pressed into soft capsule by suspension is filling, washes away soft capsule
Appearance oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
Embodiment 3
A kind of soft capsule for treating adnexitis, the active ingredient and its quality that soft capsule is made are：15 parts of motherwort, radix bupleuri
9 parts, 7 parts of peach kernel, 8 parts of semen brassicae, 12 parts of decumbent corydalis tuber, 8 parts of Radix Astragali, 8 parts of Bulbophyllum calodictyon schlecht, 7 parts of akebi, 8 parts of Radix Rehmanniae, 7 parts of frutus cnidii,
8 parts of the root of three-nerved spicebush, 8 parts of frankincense, 15 parts of Radix zanthoxyli, 15 parts of ginseng, 7 parts of tangerine seed, 7 parts of Hex godajam (colebr) Wall, 7 parts of curcuma zedoary, 10 parts of coix seed,
8 parts of dried human placenta, 9 parts of clinopodium polycephalum, 10 parts of hawthorn.
The preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
After art, clinopodium polycephalum crush, being extracted 2 times with ethyl alcohol, the ethyl alcohol that the mass concentrations for adding 7 times of amounts for the first time are 90% extracts 2.5 hours,
Filtering, the ethyl alcohol that the mass concentration of second plus 5 times amount of filter residue is 80% extract 1.5 hours, and filtering merges filtrate twice, obtains
To extracting solution；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 1.5 hours with 6 times of water, filtering, filter residue is decocted 1 hour for the second time with 4 times of water, and filtering merges filtrate twice, obtains
Decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：1.04：0.5：0.52 is made suspension, with
Gelatin, glycerine, water press 1：0.5：0.8 ratio prepares rubber, is then pressed into soft capsule by suspension is filling, washes away soft capsule
Appearance oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
Embodiment 4
A kind of soft capsule for treating adnexitis, the active ingredient and its quality that soft capsule is made are：25 parts of motherwort, radix bupleuri
16 parts, 14 parts of peach kernel, 12 parts of semen brassicae, 18 parts of decumbent corydalis tuber, 12 parts of Radix Astragali, 15 parts of Bulbophyllum calodictyon schlecht, 13 parts of akebi, 12 parts of Radix Rehmanniae, snake
13 parts of machine tool, 14 parts of the root of three-nerved spicebush, 12 parts of frankincense, 25 parts of Radix zanthoxyli, 25 parts of ginseng, 15 parts of tangerine seed, 15 parts of Hex godajam (colebr) Wall, curcuma zedoary 13
Part, 20 parts of coix seed, 12 parts of dried human placenta, 15 parts of clinopodium polycephalum, 15 parts of hawthorn.
The preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
It after art, clinopodium polycephalum crush, is extracted 2 times with ethyl alcohol, the ethyl alcohol that the mass concentrations for adding 8 times of amounts for the first time are 90% extracts 2 hours, mistake
Filter, the ethyl alcohol that the mass concentration of second plus 4 times amount of filter residue is 80% extract 2 hours, and filtering merges filtrate twice, carried
Take liquid；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 1.5 hours with 7 times of water, filtering, filter residue is decocted 1 hour for the second time with 4 times of water, and filtering merges filtrate twice, obtains
Decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：1.02：0.5：0.5 is made suspension, with bright
Glue, glycerine, water press 1：0.4：0.8 ratio prepares rubber, is then pressed into soft capsule by suspension is filling, washes away outside soft capsule
Table oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
Embodiment 5
A kind of soft capsule for treating adnexitis, the active ingredient and its quality that soft capsule is made are：20 parts of motherwort, radix bupleuri
12 parts, 11 parts of peach kernel, 10 parts of semen brassicae, 15 parts of decumbent corydalis tuber, 10 parts of Radix Astragali, 12 parts of Bulbophyllum calodictyon schlecht, 10 parts of akebi, 10 parts of Radix Rehmanniae, snake
10 parts of machine tool, 11 parts of the root of three-nerved spicebush, 10 parts of frankincense, 20 parts of Radix zanthoxyli, 20 parts of ginseng, 11 parts of tangerine seed, 11 parts of Hex godajam (colebr) Wall, curcuma zedoary 10
Part, 15 parts of coix seed, 10 parts of dried human placenta, 12 parts of clinopodium polycephalum, 12 parts of hawthorn.
The preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
It after art, clinopodium polycephalum crush, is extracted 2 times with ethyl alcohol, the ethyl alcohol that the mass concentrations for adding 6 times of amounts for the first time are 90% extracts 3 hours, mistake
Filter, the ethyl alcohol that the mass concentration of second plus 6 times amount of filter residue is 80% extract 2 hours, and filtering merges filtrate twice, carried
Take liquid；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 2 hours with 5 times of water, filtering, filter residue is decocted 0.5 hour for the second time with 3 times of water, and filtering merges filtrate twice, obtains
Decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：1：0.52：0.52 is made suspension, with bright
Glue, glycerine, water press 1：0.4：0.8 ratio prepares rubber, is then pressed into soft capsule by suspension is filling, washes away outside soft capsule
Table oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
Embodiment 6
A kind of soft capsule for treating adnexitis, the active ingredient and its mass fraction that soft capsule is made are：10 parts of motherwort,
20 parts of radix bupleuri, 3 parts of peach kernel, 15 parts of semen brassicae, 15 parts of decumbent corydalis tuber, 10 parts of Radix Astragali, 18 parts of Bulbophyllum calodictyon schlecht, 5 parts of akebi, 10 parts of Radix Rehmanniae,
16 parts of frutus cnidii, 10 parts of the root of three-nerved spicebush, 5 parts of frankincense, 15 parts of Radix zanthoxyli, 20 parts of ginseng, 15 parts of tangerine seed, 10 parts of Hex godajam (colebr) Wall, curcuma zedoary
10 parts, 20 parts of coix seed, 15 parts of dried human placenta, 12 parts of clinopodium polycephalum, 8 parts of hawthorn.
The preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) peach kernel, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, the cowherb of said ratio are weighed
It after art, clinopodium polycephalum crush, is extracted 2 times with ethyl alcohol, the ethyl alcohol that the mass concentrations for adding 7 times of amounts for the first time are 90% extracts 3 hours, mistake
Filter, the ethyl alcohol that the mass concentration of second plus 6 times amount of filter residue is 80% extract 1 hour, and filtering merges filtrate twice, carried
Take liquid；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, for the first time
It is decocted 2 hours with 7 times of water, filtering, filter residue is decocted 0.5 hour for the second time with 4 times of water, and filtering merges filtrate twice, obtains
Decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh nets
Sieve, gained screenings are Ultramicro-powder；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried,
Obtained extract powder is uniformly mixed with Ultramicro-powder, obtains Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：1.03：0.51：0.51 is made suspension, with
Gelatin, glycerine, water press 1：0.3：0.8 ratio prepares rubber, is then pressed into soft capsule by suspension is filling, washes away soft capsule
Appearance oil reservoir, up to the soft capsule of the treatment chronic appendages inflammation after drying.
The above is the preferred embodiment of the present invention, and its object is to person skilled in the art is allowed to understand the present invention
Content is simultaneously implemented, it is noted that for those skilled in the art, is not departing from the principle of the invention
Under the premise of, several improvements and modifications can also be made, these improvements and modifications are also considered as protection scope of the present invention.
Claims (3)
1. a kind of soft capsule for treating chronic appendages inflammation, which is characterized in that the active ingredient and its mass fraction of soft capsule is made
For：10-30 parts of motherwort, 5-20 parts of radix bupleuri, 3-18 parts of peach kernel, 5-15 parts of semen brassicae, 10-20 parts of decumbent corydalis tuber, 5-15 parts of Radix Astragali,
3-20 parts of Bulbophyllum calodictyon schlecht, 2-18 parts of akebi, 5-15 parts of Radix Rehmanniae, 4-16 parts of frutus cnidii, 2-20 parts of the root of three-nerved spicebush, 5-15 parts of frankincense, two
Needle 10-30 parts of face, 10-30 parts of ginseng, 2-20 parts of tangerine seed, 2-20 parts of Hex godajam (colebr) Wall, 4-16 parts of curcuma zedoary, 5-25 parts of coix seed, purple river
5-15 parts of vehicle, 4-20 parts of clinopodium polycephalum, 5-20 parts of hawthorn；
Wherein, the preparation method of the soft capsule of the treatment chronic appendages inflammation includes the following steps：
(1) weigh the peach kernel of said ratio, Radix Rehmanniae, frutus cnidii, the root of three-nerved spicebush, frankincense, Radix zanthoxyli, tangerine seed, Hex godajam (colebr) Wall, curcuma zedoary,
After clinopodium polycephalum crushes, extracted 2 times with ethyl alcohol, for the first time plus the 6-8 times of mass concentration measured is extracted 2-3 hours for 90% ethyl alcohol,
The ethyl alcohol that filtering, filter residue second plus the 4-6 times of mass concentration measured are 80% extracts 1-2 hour, filtering, merging filtrate twice,
Obtain extracting solution；
(2) radix bupleuri, decumbent corydalis tuber, Radix Astragali, Bulbophyllum calodictyon schlecht, akebi, the ginseng for weighing said ratio carry out secondary decoction, use 5- for the first time
7 times of water decocts 1-2 hours, filtering, and filter residue is decocted 0.5-1 hours for the second time with 3-4 times of water, and filtering merges filtrate twice,
Obtain decoction liquor；
(3) ultramicro grinding is carried out after mixing motherwort, semen brassicae, coix seed, dried human placenta, hawthorn, and crosses 625 mesh mesh screens, institute
It is Ultramicro-powder to obtain screenings；
(4) decoction liquor made from extracting solution made from step (1) and step (2) after mixing, is spray-dried, is obtained
Extract powder be uniformly mixed with Ultramicro-powder, obtain Chinese herbal medicine mixed-powder；
(5) Chinese herbal medicine mixed-powder, olive oil, Aloe Vera Gel, beeswax are pressed 1：(1-1.04)：(0.5-0.52)：(0.5-0.52)
Suspension is made, 1 is pressed with gelatin, glycerine, water：(0.3-0.5)：0.8 ratio prepares rubber, then by the filling compacting of suspension
Into soft capsule, soft capsule appearance oil reservoir is washed away, up to the soft capsule of the treatment chronic appendages inflammation after drying.
2. a kind of soft capsule for treating chronic appendages inflammation as described in claim 1, which is characterized in that the effective of soft capsule is made
Ingredient and its mass fraction are：15-25 parts of motherwort, 9-16 parts of radix bupleuri, 7-14 parts of peach kernel, 8-12 parts of semen brassicae, decumbent corydalis tuber 12-
18 parts, 8-12 parts of Radix Astragali, 8-15 parts of Bulbophyllum calodictyon schlecht, 7-13 parts of akebi, 8-12 parts of Radix Rehmanniae, 7-13 parts of frutus cnidii, root of three-nerved spicebush 8-14
Part, 8-12 parts of frankincense, 15-25 parts of Radix zanthoxyli, 15-25 parts of ginseng, 7-15 parts of tangerine seed, 7-15 parts of Hex godajam (colebr) Wall, 7-13 parts of curcuma zedoary, the heart of a lotus seed
10-20 parts of the seed of jog's tears, 8-12 parts of dried human placenta, 9-15 parts of clinopodium polycephalum, 10-15 parts of hawthorn.
3. a kind of soft capsule for treating chronic appendages inflammation as described in claim 1, which is characterized in that the effective of soft capsule is made
Ingredient and its mass fraction are：20 parts of motherwort, 12 parts of radix bupleuri, 11 parts of peach kernel, 10 parts of semen brassicae, 15 parts of decumbent corydalis tuber, Radix Astragali 10
Part, 12 parts of Bulbophyllum calodictyon schlecht, 10 parts of akebi, 10 parts of Radix Rehmanniae, 10 parts of frutus cnidii, 11 parts of the root of three-nerved spicebush, 10 parts of frankincense, 20 parts of Radix zanthoxyli,
20 parts of ginseng, 11 parts of tangerine seed, 11 parts of Hex godajam (colebr) Wall, 10 parts of curcuma zedoary, 15 parts of coix seed, 10 parts of dried human placenta, 12 parts of clinopodium polycephalum, hawthorn 12
Part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510004967.1A CN104547926B (en) | 2015-01-06 | 2015-01-06 | A kind of soft capsule for treating chronic appendages inflammation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510004967.1A CN104547926B (en) | 2015-01-06 | 2015-01-06 | A kind of soft capsule for treating chronic appendages inflammation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104547926A CN104547926A (en) | 2015-04-29 |
| CN104547926B true CN104547926B (en) | 2018-07-06 |
Family
ID=53065697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510004967.1A Active CN104547926B (en) | 2015-01-06 | 2015-01-06 | A kind of soft capsule for treating chronic appendages inflammation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104547926B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491673A (en) * | 2002-09-10 | 2004-04-28 | 王希杰 | Guihuangshanjia capsule and its preparing method |
| CN101129939A (en) * | 2007-08-20 | 2008-02-27 | 陈江 | Szechwan siphunculus beverage |
| CN101700372A (en) * | 2009-11-16 | 2010-05-05 | 贺芹芹 | Oral medicament for treating chronic pelvic inflammation |
| CN102716417A (en) * | 2012-06-15 | 2012-10-10 | 祁连明 | Traditional Chinese medicine preparation for treating gynaecopathia and preparation method of preparation |
-
2015
- 2015-01-06 CN CN201510004967.1A patent/CN104547926B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491673A (en) * | 2002-09-10 | 2004-04-28 | 王希杰 | Guihuangshanjia capsule and its preparing method |
| CN101129939A (en) * | 2007-08-20 | 2008-02-27 | 陈江 | Szechwan siphunculus beverage |
| CN101700372A (en) * | 2009-11-16 | 2010-05-05 | 贺芹芹 | Oral medicament for treating chronic pelvic inflammation |
| CN102716417A (en) * | 2012-06-15 | 2012-10-10 | 祁连明 | Traditional Chinese medicine preparation for treating gynaecopathia and preparation method of preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104547926A (en) | 2015-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104474291A (en) | Medicine for treating kidney stone and preparation method thereof | |
| CN101569738B (en) | Plaster for treating mastitis, hyperplasia of mammary glands, breast lumps, hydrarthrosis, traumatic injury, preparation method and application thereof | |
| CN102847074B (en) | Blood stasis removing pill for treating ankylosing spondylitis | |
| CN101417087B (en) | Medicine for treating gynecology postpartum disease and preparation method thereof | |
| CN103203006A (en) | Traditional Chinese medicine decoction for treating uterus coldness | |
| CN102784229A (en) | Externally applied fumigation-washing traditional Chinese medicine for treating sports injury and rheumatism type osteoarthropathy | |
| CN101700372B (en) | Oral medicament for treating chronic pelvic inflammation | |
| CN104983862A (en) | Traditional Chinese medicine compound for treating uterine fibroids | |
| CN104225490A (en) | Traditional Chinese medicine for treating cholecystitis | |
| CN104547926B (en) | A kind of soft capsule for treating chronic appendages inflammation and preparation method thereof | |
| CN103784806B (en) | A kind of Chinese medicine treating anemopyretic urticaria | |
| CN103230573A (en) | Traditional Chinese medicine preparation for treating endometriosis | |
| CN105311576A (en) | Traditional Chinese medicine for treating simple endometrial hyperplasia and preparation method thereof | |
| CN104069305A (en) | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof | |
| CN104784592A (en) | Traditional Chinese medicine for treating fallopian tube jam | |
| CN104306948A (en) | Medicament composition for treating gouty arthritis | |
| CN119303054A (en) | A Chinese medicine composition for treating endometriosis and preparation method thereof | |
| CN104758859A (en) | Traditional Chinese medicine for treating gynecological inflammation | |
| CN103721225B (en) | A kind of medicine for the treatment of piriformis syndrome and preparation method thereof | |
| CN105596510A (en) | Chinese patent medicine for treating miscellaneous gynecological diseases | |
| CN104127803A (en) | Traditional Chinese medicine preparation for treating qi-stagnation blood-stasis type amenorrhea | |
| CN104922605A (en) | Plaster for treating bone fracture | |
| CN103356825A (en) | Chinese medicine decoction for early treatment of bone and joint injury | |
| CN104398972A (en) | Traditional Chinese medicine treating qi-stagnation blood-stasis type hysteromyoma and preparation method | |
| CN102600440A (en) | Chinese herbal composition for treating chronic pelvic inflammation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230609 Address after: 511466 Room 2098, Building 1, No. 6, Nanjiang Second Road, the Pearl River Street, Nansha District, Guangzhou, Guangdong Province (office only) Patentee after: Guangzhou Xili biotechnology Service Co.,Ltd. Address before: No. 19, Middle Section of Tangwangshan Road, Shuangshan Subdistricts of China, Zhangqiu City, Jinan City, Shandong Province, 250200 Patentee before: Kan Xueqiao |
|
| TR01 | Transfer of patent right |