CN102335264A - Actinidia arguta and kudzuvine root oral liquid for relieving alcoholism, and preparation method thereof - Google Patents
Actinidia arguta and kudzuvine root oral liquid for relieving alcoholism, and preparation method thereof Download PDFInfo
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- CN102335264A CN102335264A CN2011103027178A CN201110302717A CN102335264A CN 102335264 A CN102335264 A CN 102335264A CN 2011103027178 A CN2011103027178 A CN 2011103027178A CN 201110302717 A CN201110302717 A CN 201110302717A CN 102335264 A CN102335264 A CN 102335264A
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Abstract
The invention relates to a healthy beverage, namely actinidia arguta and kudzuvine root oral liquid for relieving alcoholism. The oral liquid is prepared from actinidia arguta, kudzuvine root, tangerine peel, tuckahoe, astragalus, cassia seed, red dates, and honey. The oral liquid is both a medicine and food which can exert medical effects synergetically. The oral liquid has the effects of relieving alcoholism, protecting liver functions, nourishing the stomach, and strengthening brain; and after a user drinks the oral liquid, headache can be relieved, the phenomena of heavily breathing and blush can be relieved, and the user does not feel dizzy, and sobers up quickly; alcohol resistance time is long; and the oral liquid does not have toxic or side effect on a human body.
Description
Technical field
The present invention relates to a kind of health promoting beverage, promptly soft Pueraria lobota oral liquor for sobering from wine and preparation method thereof.Trade name: relieving alcoholism and protecting the liver spirit.
Background technology
In the prior art, wine is extremely paid attention in motherland's medical science, and Chinese medicine is found wine ability promoting blood circulation very early, fills a wine cup for as article commonly used in the prescription.Wine can be tied the friend good friend, increase festive air, but excessive consumption of alcohol has injury to health.The corn of wine brewing and fruit can be transformed into materials such as ethanol, methanol, alcohol oil, cyanide, lead, manganese after fermentation, wherein alcohol oil, methanol, cyanide endanger maximum to people's health.Wine is one " double-edged sword " thus, and drinking is not only to help health but also be harmful to health.The absorption ethanol (excessive drinking) of high dose, the concentration of ethanol reaches 0.4% when above in the blood, causes to contain the ability to bear that ethanol surpasses the people in the blood, toxicant can destroy liver, the injury health then for drunk be alcoholism.Medicine has better curative effect aspect the alleviation of alcohol poisoning, not only plays antialcoholism action, is intended to the liver protecting, rationally utilizes wild resource, and the article of relieving alcoholism and protecting the liver are the good merchantable brands that relieves the effect of alcohol.People press for disintoxicating product.
Fructus Actinidiae Argutae is also claimed wild Fructus actinidiae chinensis, ovateleaf actinidia leaf, Radix actinidiae argutae, circle Chinese date.Fruit is delicious, unique flavor, and sour and sweet palatability, nutritious.Sarcocarp contains multivitamin, can be rated as the king of fruit.All there is distribution on ground such as China northeast, northwest and the Yangtze river basin.The mature fruit of gathering autumn belongs to Caulis Stelmatocryptonis khasiani class xylophyta for many years, mainly is grown in dark woods depths, belongs to wild green fruit.Ripe at the beginning of 10 months.The peel green is smooth, and sarcocarp is green, succulence, and exquisiteness, moderately sour and sweet contains soluble solid about 15%, and total sugar 8.8%, organic acid 1.5%, VC430mg/100g are 100 times of Fructus Mali pumilae, aminoacid 933.9mg/100g.Actinidia arguta Sieb.et Zucc juice has the synthetic effect of blocking-up carcinogenecity nitroso compound; The hydrolytic enzyme and the superoxide dismutase (SOD) that also contain thiol proteinase; Clearing and antitussive and diuresis inducing function that similar Fructus actinidiae chinensis is arranged; Contain various trace elements and nutritional labelings such as several amino acids and pectin such as fat, albumen, calcium, phosphorus, ferrum, magnesium simultaneously, also contain actinidine, gastric cancer, esophageal carcinoma, rheumatism, jaundice are had prevention and therapeutical effect.The tool skin care arranged, improve immunologic function, strengthen anticancer, vessel softening, anti-swollen antiinflammatory, slow down skin aging, nourishing and fit keeping function, clearing away heat and promoting diuresis, the effect of promoting the production of body fluid and moisturizing.Nutrition and health care are worth high.Yet Fructus Actinidiae Argutae also rests on the edible aspect of fresh fruit, not effectively development and use.
Summary of the invention
The objective of the invention is to provide a kind of to above-mentioned deficiency is major ingredient with the Fructus Actinidiae Argutae, is used to process the effective soft Pueraria lobota oral liquor for sobering from wine and preparation method thereof that relieves the effect of alcohol.
Technical solution of the present invention is: soft Pueraria lobota oral liquor for sobering from wine is processed by the raw material of following parts by weight: Fructus Actinidiae Argutae 40-60 part, Radix Puerariae 1-2 part, 1 part of Pericarpium Citri Reticulatae, 1 part in Poria, 1 part of the Radix Astragali, 1 part of Semen Cassiae, Fructus Jujubae (or Fructus Jujubae) 2-3 part, Mel 1-3 part (or an amount of).Preferably: 50 parts of Fructus Actinidiae Argutaes, 1.3 parts of Radix Puerariaes, 1 part of Pericarpium Citri Reticulatae, 1 part in Poria, 1 part of the Radix Astragali, 1 part of Semen Cassiae, 2 parts of Fructus Jujubaes, 3 parts of Mel.
Fructus Actinidiae Argutae has the promotion intestinal peristalsis promoting, strengthens alcohol dehydrogenase activity, reduces ethanol in the time that gastric stops, and actinidine can reduce the lipid peroxide contents in the tissue; The Radix Astragali, Fructus Jujubae protection and gastric mucosa reparation strengthen the barrier action of gastric mucosa bicarbonate protective layer, reduce the damage of ethanol to gastric mucosa; Poria can quicken the metabolism of urinary system, diuresis; Inhibitory action due to Pericarpium Citri Reticulatae, Semen Cassiae, the Radix Puerariae flavone antagonism ethanol.
Preparation technology: Fructus Actinidiae Argutae is processed slurry, filtrate; Adopt conventional extracting technique of Chinese medicine (carrying) that Radix Puerariae, Pericarpium Citri Reticulatae, Poria, the Radix Astragali, Semen Cassiae and Fructus Jujubae (Fructus Jujubae fries and processes powder) are extracted, mix liquid, add that Mel is an amount of, sterilization gets final product like supercritical extraction, water.
Or the method for preparing of soft Pueraria lobota oral liquor for sobering from wine, its step is following:
1. bright Radix Puerariae, clean, dry, broken, concentration of alcohol 80% refluxes and concentrates, add 8 times of amounts at every turn, reflux, extract, 3 times, each time 9h, merging filtrate is evaporated to 50%, filtrating accent pH4.0 abandons deposition;
2. Fructus Actinidiae Argutae controlling the water circulation extract, 1-3 time, each 30 minutes at a simmer, merging filtrate;
3. Pericarpium Citri Reticulatae, Poria, the Radix Astragali, Semen Cassiae add 6-8 times of water gaging concentration contraction and become decoct;
4. the clean oven dry of Fructus Jujubae fries with slow fire and processes powder;
Mix the back and add the Mel sterilization filling.
Its compound recipe beverage of forming with Chinese medicine assembly such as Changbai Mountain wild Fructus Actinidiae Argutae extract actinidine (actinidine), Herba Boschniakiae Rossicae aldin (boschniakine) and Radix Puerariae flavone, puerarin, the Radix Astragali, Poria of soft Pueraria lobota oral liquor for sobering from wine.Main material is a Fructus Actinidiae Argutae.Fructus Actinidiae Argutae contains vitamin C, vitamin A and nicotinic acid, contains the hydrolytic enzyme and the superoxide dismutase (SOD) of thiol proteinase.
Soft Pueraria lobota oral liquor for sobering from wine has the preventive effect to acute alcoholism.We utilize chmice acute ethylism model, from the neuromuscular coordination ability, toxicological experiment with to several indexs such as gastric mucosa, liver tissue injury degree, have verified the preventive effect of soft Pueraria lobota oral liquor for sobering from wine to ethanol calomel poisoning and severe intoxication respectively.The soft Pueraria lobota oral liquor for sobering from wine of preliminary proof can alleviate the poisoning symptom of mice.Soft Pueraria lobota oral liquor for sobering from wine can effectively reduce the concentration of alcohol in the mice plasma, mainly is to absorb at gastrointestinal through suppressing ethanol, increases the alcohol dehydrogenase activity of liver and accelerates alcohol metabolism.The main intestinal peristalsis promoting that promotes in addition of soft Pueraria lobota oral liquor for sobering from wine can be treated constipation.Experiment acts on the rabbit intestinal through Alumen, finds that soft Pueraria lobota oral liquor for sobering from wine can resist the intestinal peristalsis promoting of Alumen influence to slow down phenomenon, can obviously alleviate the back palpitating speed of drinking, dizzy phenomenon after taking soft Pueraria lobota oral liquor for sobering from wine in addition; Taking soft Pueraria lobota oral liquor for sobering from wine after drinking can make and blush phenomenon and alleviate to some extent in 10-15 minute.Took effect more in 20-30 minute before the wine.These article have integration of edible and medicinal herbs, the effect of collaborative performance drug effect.
Effect: relieve the effect of alcohol, hepatoprotective, nourishing the stomach, brain-strengthening.
Advantage of the present invention is: 1, integration of edible and medicinal herbs, collaborative performance drug effect.2, have relieve the effect of alcohol, hepatoprotective, nourishing the stomach, brain-invigorating, drink separate headache after taking, alleviate out of breath, alleviate blush phenomenon, not dizzy, an anti-liquor-saturated time long, sober up soon, health is had no side effect.
To combine embodiment that embodiment of the present invention is described in further detail below.
The specific embodiment
Embodiment 1
Soft Pueraria lobota oral liquor for sobering from wine is processed by following raw material: Fructus Actinidiae Argutae 750g, and Radix Puerariae 20g, Pericarpium Citri Reticulatae 15g, Poria 15g, Radix Astragali 15g, Semen Cassiae 15g, Fructus Jujubae 30g, Mel 15g (Mel and decoct ratio also can be 1/10) processes water decoction 150ml.
Embodiment 2
Soft Pueraria lobota oral liquor for sobering from wine is processed by following raw material: Fructus Actinidiae Argutae 600g, and Radix Puerariae 20g, Pericarpium Citri Reticulatae 15g, Poria 15g, Radix Astragali 15g, Semen Cassiae 15g, Fructus Jujubae 30g, Mel 15g processes water decoction 150ml.
Embodiment 3
Soft Pueraria lobota oral liquor for sobering from wine is processed by following raw material: Fructus Actinidiae Argutae 900g, and Radix Puerariae 20g, Pericarpium Citri Reticulatae 15g, Poria 15g, Radix Astragali 15g, Semen Cassiae 15g, Fructus Jujubae 30g, Mel 15g processes water decoction 150ml.
Embodiment 4
Soft Pueraria lobota oral liquor for sobering from wine is processed by following raw material: Fructus Actinidiae Argutae 750g, and Radix Puerariae 20g, Pericarpium Citri Reticulatae 15g, Poria 15g, Radix Astragali 15g, Semen Cassiae 15g, Fructus Jujubae 30g, Mel 75g processes water decoction 150ml.
Experimental example-the experiment of soft Pueraria lobota oral liquor for sobering from wine in the chmice acute ethylism
1 material
1.1 medicine
Soft Pueraria lobota oral liquor for sobering from wine; Make every effort to overcome health care liquid health food lot number: No. 169 Ministry of Health of the People's Republic of China's approval of hygienic food and health number (1997), make every effort to overcome 100ml/ bottle * 10 bottle/boxes * 6 boxes/case.
1.2 animal
Kunming mouse, Changchun High-technology Medical Animal Experiment Research Center provides, production licence number SCXK (Ji) 2008-0005, occupancy permit SCXK (Ji) 2008-0005.
1.3 reagent
The biochemical level of ethanol dehydrogenase (Shanghai section is emerging); NAD (Shanghai hundred million is glad); Dehydrated alcohol (East China, Shenyang); Tetrasodium pyrophosphate (Shenyang is newly changed); Sodium citrate (Shen Shi Xin Xi); Citric acid (Tianjin Ke Miou); Sodium hydroxide (Tianjin Ke Miou).
1.4 instrument
T6 spectrophotometer (Beijing general analyse general); 800 type centrifugation devices (Shanghai Surgical Operation Equipment Factory);
2 methods
2.1 the foundation of animal model
Mice is raised in the dustless environment of cleaning, 18～20 ℃ of temperature, and relative humidity 55%, illumination 12h, artificial feeding, feedstuff is provided by Changchun High-technology Medical Animal Experiment Research Center.Mice is divided into matched group, model group, treatment group and positive drug group at random, 10 every group.Model group three each 0.34ml/20g of ip50% ethanol every day; Implement the soft Pueraria lobota oral liquor for sobering from wine of ip 3ml/20g before the treatment group ip50% ethanol; Matched group ip equivalent normal saline.
2.2 biochemical indicator is measured
After the administration 20 days, the cervical vertebra dislocation method is put to death mice, extracts heart blood, and takes out stomach, liver.(pH 8.8 sodium pyrophosphate buffer solutions: 1.427g sodium pyrophosphate decahydrate (Na2P2071OH2O) is dissolved in distilled water, with 1molL-1 NaOH solution pH is transferred to 8.8, and standardize solution is to 100.00ml to add sodium pyrophosphate buffer solution in the blood sample.) 1.5ml, NAD1.0ml, the centrifugal 10min of 1500r/min collects supernatant, utilizes T6 spectrophotometric determination ethanol dehydrogenase (ADH), glutamate pyruvate transaminase (ALT) activity, to detect the mouse blood ethanol content.
2.3 histopathology
2.3.1 gastric mucosa damage observation is got stomach and is cut off along greater gastric curvature, measures gastric mucosa degree of injury (ulcer surface/gastric surface amasss %).
2.3.2 liver tissue injury is observed
Get liver, use normal saline flushing, after filter paper blots, weigh, the statistics liver is heavy. and be cut into small pieces, process paraffin section, observe through the HE rearmounted microscopically that dyes.
3 results
3.1 alcohol dehydrogenase activity was measured after drug absorption was gone into blood
Ethanol dehydrogenase (ADH) is that the main enzyme that ethanol decomposes is to be present in people's the liver.After drinking, the ethanol in blood amount increases, and alcohol dehydrogenase activity strengthens, and is used for decomposing ethanol and forms acetaldehyde.Acetaldehyde is a kind of virose material, assembles excessive meeting and causes nerve problems, and excessive consumption of alcohol, this material can accumulate in and poison liver (7-8) in the hepatic tissue.Under the normal condition; ADH in the serum active (Abs) is constant, and product reduced coenzyme (NADH) has absorbance value (K*Abs) in the alcohol metabolism process at the 340nm place, so with the content of NADH in the spectrophotometry serum; The activity that just can reflect ADH in the serum indirectly; Measured data are carried out variance analysis, and the treatment group is than model group ADH activity low (* p＜0.05), and the treatment group is lower than positive drug group (* * p＜0.01) and sees table 1.Explain that the treatment group takes soft Pueraria lobota oral liquor for sobering from wine and can stimulate body to produce aldehyde dehydrogenase preferably and improve enzymatic activity; Suppress the gathering of acetaldehyde; Helping ethanol decomposes fast; Reduced the murder by poisoning of acetaldehyde, quickened the acetaldehyde that oxidation of acetaldehyde becomes acetic acid and directly act on generation and protected liver liver.
Table 1 alcohol dehydrogenase activity (ADH)
3.2 drug absorption is gone into serum two-story valley pyruvic transaminase (ALT) assay behind the blood
Warp is to glutamate pyruvate transaminase determination of activity in the blood, and the treatment group is starkly lower than model group and matched group, and the positive drug group is taken second place.When the liver structure mutation, gpt activity strengthens, after excessive alcohol gets into body; The acetaldehyde that has little time to decompose is trapped in the liver; Cause abnormal liver function, directly cause glutamate pyruvate transaminase high, table 2 display model group is apparently higher than treatment group and positive drug group.
ALT value (u)/L in table 2 mice serum
3.3 ethanol influences gastric mucosa
Compare with model group, treatment group gastric mucosa injury tolerance is little, is superior to positive drug group and matched group, and the ulcer area statistics is seen table 3.
Table 3 gastric mucosa damaged area (ulcerate the stomach lining face cm
2)
Annotate: * P＜0.05
3.4 ethanol influences liver
Process paraffin section with matched group relatively shows through HE dyeing, model group hepatocyte kytoplasm is fine and close, does not see neat hepatic sinusoid, and liver plate arrangement disorder the cell fusion embodiment occurs and resembles; Positive drug group liver color dark brown, tunicle and liver parenchyma have adhesion in various degree, but are prone to strip off, and hepatic cords is clear; Treatment group liver color dark brown, tunicle and liver parenchyma also have adhesion in various degree, visible hepatic cords and marshalling, the lobules of liver boundary is clear, and hepatic sinusoid is clear, and tubule is clear, and central vein is obvious.
3.5 ethanol is tested mouse toxicity
Show that through toxicity test survival rate is 0 behind the model group ip; Treatment group survival rate is higher than the positive drug group.The result sees table 4.Shown that through mensuration the anti-drunk time of treatment group is 8.6min, be superior to the positive drug group the anti-liquor-saturated time of mice and the time of sobering up.The result sees table 5.
Table 4 ethanol is to the acute toxicity (n=20) of mice
3.6 mice drunk, the timing of sobering up
After ethanol was irritated stomach, drunk reaction in various degree appearred in mice, and record mice active state, drunk time (are that righting reflex loss is drunk; Sober up to reverting to) required time (min) sees table 2: through record righting reflex loss (drunk) to recovering (sobering up) required time (min): see table 2.
The drunk phenomenon experiment of table 5 (n=5)
4 discuss
Fructus Actinidiae Argutae is also claimed wild Fructus actinidiae chinensis, has anticancer, as to slow down skin aging effect, belongs to wild green fruit.The Fructus Actinidiae Argutae place of production mainly is Changbai Mountain one arteries and veins, and fruit contains abundant vitamin, sugar content is 7～16%.Loosening bowel to relieve constipation had better curative effect.Also can be used as the first-class material of antialcoholic.
The metabolic pathway of ethanol in human body has three: liver detoxification, intestinal peristalsis promoting, urinate.Soft Pueraria lobota oral liquor for sobering from wine can effectively be started with from these three links; Organic acid in the fruit, vitamin C (75～90 milligrams of %), vitamin A, Citrin improve the human liver relieve the effect of alcohol enzyme efficient and accelerate the decomposition and inversion of ethanol, protection cranial nerve and each organ of human body; Sucrose, phlegmatic temperament, starch, protein, tannin can be strengthened the bicarbonate barrier action, thereby have alleviated the stimulation of ethanol to stomach; Thereby the sanguimotor ethanol of entering is drained as early as possible, reduced, alleviate the burden of liver digested, thereby improve the liver digestion power, the advanced part of relieving alcoholism and protecting the liver spirit that Here it is in the gastrointestinal tract time of staying.Simultaneously, well consider again to have arranged human body is played the composition that effect is taken good care of in health care.Soft Pueraria lobota oral liquor for sobering from wine has dispersing the stagnated live-QI to relieve the stagnation of QI, spleen invigorating, calms the nerves, the effect of nourishing lung-YIN, reinforcing stomach reg fluid, air making-up and spleen enlivening, be suitable for insobriety or drink before take, prevent and remove the injury of excessive drinking effectively to the human stomach regulating liver-QI.Be the health promoting beverage of current ideal liver-protecting and stomach-nourishing, develop and develop ideal relieving or neutralizing effect of alcohol, protecting liver and nourishing stomach sedative health-care article and have great importance and vast market prospect.
Claims (4)
1. a soft Pueraria lobota oral liquor for sobering from wine is characterized in that being processed by the raw material of following parts by weight: Fructus Actinidiae Argutae 40-60 part, Radix Puerariae 1-2 part, 1 part of Pericarpium Citri Reticulatae, 1 part in Poria, 1 part of the Radix Astragali, 1 part of Semen Cassiae, Fructus Jujubae 2-3 part, Mel 1-3 part.
2. according to the described soft Pueraria lobota oral liquor for sobering from wine of claim 1, it is characterized in that 50 parts of Fructus Actinidiae Argutaes, 1.3 parts of Radix Puerariaes, 1 part of Pericarpium Citri Reticulatae, 1 part in Poria, 1 part of the Radix Astragali, 1 part of Semen Cassiae, 2 parts of Fructus Jujubaes, 3 parts of Mel.
3. according to claim 1 or 2 described soft Pueraria lobota oral liquor for sobering from wine, it is characterized in that Fructus Actinidiae Argutae 750g, Radix Puerariae 20g, Pericarpium Citri Reticulatae 15g, Poria 15g, Radix Astragali 15g, Semen Cassiae 15g, Fructus Jujubae 30g, Mel 75g processes water decoction 150ml.
4. like the method for preparing of claim 1,2 or 3 described soft Pueraria lobota oral liquor for sobering from wine, it is characterized in that step is following:
1. bright Radix Puerariae, clean, dry, broken, concentration of alcohol 80% refluxes and concentrates, add 8 times of amounts at every turn, reflux, extract, 3 times, each time 9h, merging filtrate is evaporated to 50%, filtrating accent pH4.0 abandons deposition;
2. Fructus Actinidiae Argutae controlling the water circulation extract, 1-3 time, each 30 minutes at a simmer, merging filtrate;
3. Pericarpium Citri Reticulatae, Poria, the Radix Astragali, Semen Cassiae add 6-8 times of water gaging concentration contraction and become decoct;
4. the clean oven dry of Fructus Jujubae fries with slow fire and processes powder;
Mix the back and add the Mel sterilization filling.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105707765A (en) * | 2016-02-06 | 2016-06-29 | 尤丽康（江苏）生物医药有限公司 | Liver protection plant oral liquid and preparation method thereof |
| CN108835331A (en) * | 2018-07-06 | 2018-11-20 | 河南百缘康药业有限公司 | A kind of pueraria lobata Antialcoholic tea |
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| CN1291499A (en) * | 2000-10-16 | 2001-04-18 | 郭兴华 | Sobering-up composition |
| CN1296779A (en) * | 2000-11-27 | 2001-05-30 | 湖南省凤凰绿色食品有限公司 | Health-care sobering-up carambola juice beverage |
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- 2011-10-09 CN CN2011103027178A patent/CN102335264A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291499A (en) * | 2000-10-16 | 2001-04-18 | 郭兴华 | Sobering-up composition |
| CN1296779A (en) * | 2000-11-27 | 2001-05-30 | 湖南省凤凰绿色食品有限公司 | Health-care sobering-up carambola juice beverage |
Non-Patent Citations (1)
| Title |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105707765A (en) * | 2016-02-06 | 2016-06-29 | 尤丽康（江苏）生物医药有限公司 | Liver protection plant oral liquid and preparation method thereof |
| CN108835331A (en) * | 2018-07-06 | 2018-11-20 | 河南百缘康药业有限公司 | A kind of pueraria lobata Antialcoholic tea |
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Application publication date: 20120201 |