CN102334021A - 用于流式细胞仪的稳定的光学系统 - Google Patents

用于流式细胞仪的稳定的光学系统 Download PDF

Info

Publication number
CN102334021A
CN102334021A CN2010800094738A CN201080009473A CN102334021A CN 102334021 A CN102334021 A CN 102334021A CN 2010800094738 A CN2010800094738 A CN 2010800094738A CN 201080009473 A CN201080009473 A CN 201080009473A CN 102334021 A CN102334021 A CN 102334021A
Authority
CN
China
Prior art keywords
light
sample
optical
sample flow
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800094738A
Other languages
English (en)
Chinese (zh)
Inventor
迈克尔·M·莫雷尔
尼尔·R·文利厄
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of CN102334021A publication Critical patent/CN102334021A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1438—Using two lasers in succession

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN2010800094738A 2009-02-27 2010-02-23 用于流式细胞仪的稳定的光学系统 Pending CN102334021A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15630609P 2009-02-27 2009-02-27
US61/156,306 2009-02-27
US12/710,100 2010-02-22
US12/710,100 US20100220315A1 (en) 2009-02-27 2010-02-22 Stabilized Optical System for Flow Cytometry
PCT/US2010/025081 WO2010099118A1 (en) 2009-02-27 2010-02-23 Stabilized optical system for flow cytometry

Publications (1)

Publication Number Publication Date
CN102334021A true CN102334021A (zh) 2012-01-25

Family

ID=42135909

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800094738A Pending CN102334021A (zh) 2009-02-27 2010-02-23 用于流式细胞仪的稳定的光学系统

Country Status (5)

Country Link
US (1) US20100220315A1 (https=)
EP (1) EP2401599A1 (https=)
JP (1) JP2012519278A (https=)
CN (1) CN102334021A (https=)
WO (1) WO2010099118A1 (https=)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103424343A (zh) * 2012-05-25 2013-12-04 阿自倍尔株式会社 光学式粒子检测装置以及粒子的检测方法
CN103424351A (zh) * 2012-05-17 2013-12-04 索尼公司 样本馈送装置、流式细胞仪以及样本馈送方法
CN104487818A (zh) * 2012-06-19 2015-04-01 美利坚合众国政府,由海军部长所代表 用于流动流体系统的远程多传感器光学颗粒监测器
CN104969055A (zh) * 2013-03-14 2015-10-07 雅培实验室 流式细胞仪系统的光束成形光学器件及其相关方法
CN105917211A (zh) * 2013-11-19 2016-08-31 艾森生物科学公司 用于流式细胞仪的光学引擎、流式细胞仪系统及使用方法
CN106053311A (zh) * 2016-08-16 2016-10-26 广东美的制冷设备有限公司 一种粉尘传感器
CN107991221A (zh) * 2017-12-01 2018-05-04 天津大学 光纤式微颗粒检测与计数方法及系统
CN107995950A (zh) * 2015-08-12 2018-05-04 生物辐射实验室股份有限公司 用于流式细胞术的多光谱滤波器剖析及质量控制
CN108291867A (zh) * 2015-07-01 2018-07-17 曼塔仪器股份有限公司 用于液体中纳米颗粒的显微观察的专用试管组件和方法
CN108489885A (zh) * 2018-04-24 2018-09-04 中翰盛泰生物技术股份有限公司 一种用于流式荧光收集的光学系统及装置
CN108627432A (zh) * 2016-03-16 2018-10-09 马尔文仪器有限公司 粒子表征
US10261080B2 (en) 2013-11-19 2019-04-16 Acea Biosciences, Inc. Optical detection system for flow cytometer, flow cytometer system and methods of use
CN110274853A (zh) * 2013-06-03 2019-09-24 爱克斯崔里斯科技有限公司 颗粒检测系统及相关方法
CN110446917A (zh) * 2017-03-23 2019-11-12 Atonarp株式会社 光学头和测量设备
US10648913B2 (en) 2011-10-21 2020-05-12 Acea Biosciences, Inc. System and method for detecting multiple-excitation-induced light in a flow channel
CN111164415A (zh) * 2017-09-29 2020-05-15 苹果公司 路径解析的光学采样架构
CN111361771A (zh) * 2020-03-23 2020-07-03 陈龙刚 一种细胞悬液分装装置
CN112014272A (zh) * 2020-08-10 2020-12-01 北京大学 一种纳米粒子传感器及纳米粒子检测方法
CN113316715A (zh) * 2019-01-31 2021-08-27 快速定量微生物学股份有限公司 一种包括用于流体样品的通道的盒、包括盒的组件以及将光学装置与盒的通道对齐的方法
CN113702269A (zh) * 2016-01-21 2021-11-26 东京毅力科创株式会社 药液供给装置和涂敷显影系统
CN113711008A (zh) * 2019-03-13 2021-11-26 马克思-普朗克科学促进协会 用于粒子测试的装置和方法
CN114112873A (zh) * 2021-11-23 2022-03-01 清华大学 用于流式细胞仪的片上荧光色散光路的波导设计
CN115452683A (zh) * 2022-08-05 2022-12-09 北京指真生物科技有限公司 一种荧光收集镜头及荧光收集系统
CN115901581A (zh) * 2018-03-30 2023-04-04 Idexx实验室公司 流式细胞仪的激光光学组件
CN116438438A (zh) * 2020-11-10 2023-07-14 华盛顿大学 用于基于流动的单颗粒和/或单分子分析的方法和设备
CN117083552A (zh) * 2021-01-29 2023-11-17 相干公司 用于温度鲁棒性激光束组合和传送的光机械组件
CN117098980A (zh) * 2021-02-04 2023-11-21 贝克顿·迪金森公司 集成光询问模块及其使用方法
US11852318B2 (en) 2020-09-09 2023-12-26 Apple Inc. Optical system for noise mitigation
US11960131B2 (en) 2018-02-13 2024-04-16 Apple Inc. Integrated photonics device having integrated edge outcouplers
US12007275B2 (en) 2016-04-21 2024-06-11 Apple Inc. Optical system for reference switching

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130056398A1 (en) * 2006-12-08 2013-03-07 Visys Nv Apparatus and method for inspecting and sorting a stream of products
GB201112726D0 (en) * 2011-07-22 2011-09-07 Molecular Vision Ltd An optical device
US20150260628A1 (en) 2011-12-01 2015-09-17 P.M.L - Particles Monitoring Technologies Ltd. Detection scheme for particle size and concentration measurement
EP2810063B1 (en) * 2012-02-04 2021-08-25 Centre for Cellular and Molecular Platforms (C-CAMP) Microfluidic flow analyzer for pathological detection and method thereof
US9871948B2 (en) * 2012-03-29 2018-01-16 Ecole polytechnique fédérale de Lausanne (EPFL) Methods and apparatus for imaging with multimode optical fibers
EP2861955A4 (en) * 2012-06-15 2016-06-08 Handyem Inc METHOD AND FLOW CELL FOR IDENTIFICATION OF PARTICLES BY NON-GAUSS SCHEDULE OF SIGNALS
US8994941B2 (en) 2012-11-28 2015-03-31 General Electric Company Optical system, apparatus and method for performing flow cytometry
AU2014235403B2 (en) * 2013-03-15 2018-06-28 Beckman Coulter, Inc. Optics system for a flow cytometer
US9494531B2 (en) 2013-08-09 2016-11-15 Kla-Tencor Corporation Multi-spot illumination for improved detection sensitivity
US20150077860A1 (en) * 2013-09-13 2015-03-19 Rocco D. Pochy Beam Profile in Particle Counter
WO2015041742A1 (en) * 2013-09-17 2015-03-26 Coherent, Inc. Apparatus for delivery of laser-beams of different wavelengths to a flow-cytometer
JP5945529B2 (ja) * 2013-12-25 2016-07-05 本田技研工業株式会社 微粒子撮影装置及び流速計測装置
EP3152545A2 (en) * 2014-06-05 2017-04-12 IntelliCyt Corporation Flow cytometer with optical system assembly
US9453791B2 (en) * 2014-07-01 2016-09-27 Octrolix Bv Flow cytometry system and method
FR3024738B1 (fr) * 2014-08-11 2018-06-15 Genes Diffusion Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique
EP3186617A4 (en) * 2014-08-27 2018-04-25 Pacific Biosciences Of California, Inc. Arrays of integrated analytcal devices
CN104459975B (zh) * 2014-12-29 2016-08-24 中国科学院长春光学精密机械与物理研究所 成像流式细胞仪的显微成像光学系统
WO2016118333A1 (en) * 2015-01-21 2016-07-28 Stratedigm, Inc. Systems and methods for detecting a particle
JP6713477B2 (ja) * 2015-03-06 2020-06-24 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 集光システムならびにその製造および使用方法
WO2017040431A1 (en) 2015-09-01 2017-03-09 Bribbla Dynamics Llc Reference switch architectures for noncontact sensing of substances
EP3352892A4 (en) * 2015-09-22 2019-06-05 Wyatt Technology Corporation METHOD AND DEVICE FOR MEASURING SEVERAL SIGNALS FROM A LIQUID SAMPLE
US20170089881A1 (en) * 2015-09-29 2017-03-30 The Board Of Trustees Of The University Of Illinois System and method for high-throughput, optomechanical flow cytometry
CN110121643B (zh) * 2016-07-15 2022-04-19 安捷伦科技有限公司 用于流式细胞仪的光学检测系统、流式细胞仪系统及其使用方法
DE102016119268B3 (de) 2016-10-10 2017-12-21 Leica Microsystems Cms Gmbh Schiefebenenmikroskop
US11536719B2 (en) 2016-10-21 2022-12-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular nanotags
KR20180051844A (ko) * 2016-11-09 2018-05-17 (주)뉴옵틱스 혈구 분석 시스템 및 분석방법
DE102017201252A1 (de) * 2017-01-26 2018-07-26 Universität Ulm Verfahren und Vorrichtung zur Untersuchung von Zellen
KR101970689B1 (ko) * 2017-08-29 2019-04-19 피엠씨씨 주식회사 광섬유를 이용한 유세포 분석 시스템
EP3701246B1 (en) * 2017-10-23 2021-02-24 The U.S.A. as represented by the Secretary, Department of Health and Human Services Optical configuration methods for spectral scatter flow cytometry
US12429412B2 (en) * 2017-10-25 2025-09-30 Government Of The United States Of America, As Represented By The Secretary Of Commerce Serial flow cytometer
JP7326256B2 (ja) 2017-10-26 2023-08-15 パーティクル・メージャーリング・システムズ・インコーポレーテッド 粒子計測システム及び方法
DE102018203301A1 (de) * 2018-03-06 2019-09-12 Robert Bosch Gmbh Mit Laser induzierter Inkandeszenz arbeitender Partikelsensor mit einer konfokalen Anordnung eines Laserspots und eines Temperaturstrahlungsspots
DE102018218912A1 (de) * 2018-11-06 2020-05-07 Robert Bosch Gmbh Partikelsensor zur Detektion von Partikeln oder Aerosol in einem strömenden Fluid unter Verwendung des Prinzips der laserinduzierten Inkandeszenz
US11169386B2 (en) * 2019-04-24 2021-11-09 Coherent, Inc. Beam forming with focus location adjustment
EP3994449A4 (en) * 2019-07-03 2023-08-16 Centre for Cellular and Molecular Platforms A microfluidic analyser
EP3812744A1 (en) * 2019-10-24 2021-04-28 Centre National de la Recherche Scientifique Apparatus for performing photochemical measurements on a liquid or liquid-containing sample
JP2021076451A (ja) * 2019-11-07 2021-05-20 ソニー株式会社 検出光学系、検出装置、フローサイトメータ及びイメージングサイトメータ
US11988593B2 (en) * 2019-11-22 2024-05-21 Particle Measuring Systems, Inc. Advanced systems and methods for interferometric particle detection and detection of particles having small size dimensions
JP7420551B2 (ja) * 2019-12-27 2024-01-23 リオン株式会社 粒子測定装置
US11709125B2 (en) * 2020-02-19 2023-07-25 Becton, Dickinson And Company Strobed laser excitation systems and methods of use thereof
EP4211441A4 (en) * 2020-09-10 2024-02-28 Becton, Dickinson and Company LASER LIGHT PROPAGATION SYSTEMS FOR IRRADIATION OF A SAMPLE IN A FLOW FLOW AND METHODS OF USE THEREOF
US20220120658A1 (en) * 2020-10-20 2022-04-21 Becton, Dickinson And Company Flow cytometers including tilted beam shaping optical components, and methods of using the same
EP4244599A4 (en) * 2020-11-16 2024-10-02 Becton, Dickinson and Company Flow cyometers including light collection modules, and methods of using the same
US12203856B2 (en) * 2021-01-20 2025-01-21 Electronics And Telecommunications Research Institute Fluorescence generating device and digital polymerase chain reaction analysis system including the same
WO2022164672A1 (en) * 2021-01-27 2022-08-04 Becton, Dickinson And Company Flow cytometers including fiber optic light collectors, and methods of use thereof
EP4047347B1 (en) * 2021-02-23 2026-04-08 Cellular Highways Ltd. Optical particle analyser with illumination at an oblique angle onto a non-transparent microfluidic chip
US11733156B2 (en) * 2021-02-23 2023-08-22 Joseph R. Demers Semiconductor package for free-space coupling of radiation and method
EP4330653A1 (en) * 2021-04-27 2024-03-06 Life Technologies Corporation Optical fiber pitch adjustment
JP2024533164A (ja) * 2021-09-03 2024-09-12 ザルトリウス バイオアナリティカル インストゥルメンツ， インコーポレイテッド 廃液流に背圧を印加するフローサイトメトリシステム
KR102555301B1 (ko) * 2021-10-13 2023-07-12 연세대학교 산학협력단 정밀 형상 가변형 섬유 장치
US20230221178A1 (en) * 2022-01-11 2023-07-13 Modulight Corporation Apparatus and a method for fluorescence imaging
US12449360B2 (en) * 2022-01-11 2025-10-21 Modulight Corporation Apparatus and method for fluorescence excitation and detection
WO2023189628A1 (ja) * 2022-03-30 2023-10-05 富士フイルム株式会社 フローセル、および測定方法
DE102022123464A1 (de) * 2022-09-14 2024-03-14 Q.ant GmbH Vorrichtung und Verfahren zur Charakterisierung eines Partikels
US12449341B2 (en) * 2022-11-09 2025-10-21 United States Of America, As Represented By The Secretary Of Commerce Optical particle characterization apparatus

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040061853A1 (en) * 2002-09-27 2004-04-01 Blasenheim Barry J. Prism-based flow cytometry excitation optics
JP2005221327A (ja) * 2004-02-04 2005-08-18 Ngk Insulators Ltd 測定装置及びその製造方法
CN101061381A (zh) * 2004-11-18 2007-10-24 奥里巴Abx股份有限公司（简单形式） 利用配置的光引导装置的均匀照明光检查流体的装置
CN101065656A (zh) * 2004-09-28 2007-10-31 霍尼韦尔国际公司 具有远心光学系统的血细胞计数器
WO2008128213A1 (en) * 2007-04-12 2008-10-23 Regents Of The University Of Minnesota Systems and methods for analyzing a particulate

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4019125A (en) * 1975-10-17 1977-04-19 Dresser Industries, Inc. Well logging pad devices having selective differential relief
WO1985005680A1 (en) * 1984-06-01 1985-12-19 Shapiro Howard M Optical systems for flow cytometers
US4702598A (en) * 1985-02-25 1987-10-27 Research Corporation Flow cytometer
JPS62222144A (ja) * 1986-03-25 1987-09-30 Toshiba Corp 粒径測定装置
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
US5013150A (en) * 1988-04-01 1991-05-07 Syntex (U.S.A.) Inc. Method for detection of fluorescence or light scatter
JPH01277740A (ja) * 1988-04-30 1989-11-08 Asahi Seimitsu Kk 水中濁度計装置
JPH01301146A (ja) * 1988-05-30 1989-12-05 Hitachi Electron Eng Co Ltd 微粒子特性測定装置
US5760900A (en) * 1989-03-18 1998-06-02 Canon Kabushiki Kaisha Method and apparatus for optically measuring specimen
US5337381A (en) * 1993-01-21 1994-08-09 Fiberguide Industries Fiber optic cylindrical diffuser
DE69638321D1 (de) * 1995-10-11 2011-03-03 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
JP3662376B2 (ja) * 1996-05-10 2005-06-22 浜松ホトニクス株式会社 内部特性分布の計測方法および装置
JP4136017B2 (ja) * 1996-09-19 2008-08-20 シスメックス株式会社 粒子分析装置
US5901264A (en) * 1997-06-12 1999-05-04 Fiberguide Industries Solar resistant optical fiber and method
AU8148898A (en) * 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
US5907650A (en) * 1997-06-26 1999-05-25 Fiberguide Industries, Inc. High precision optical fiber array connector and method
US6307630B1 (en) * 1999-11-19 2001-10-23 Hach Company Turbidimeter array system
US6470123B1 (en) * 2000-07-18 2002-10-22 Fiberguide Industries, Inc. Large optical fiber array assembly and method
JP4708605B2 (ja) * 2000-07-24 2011-06-22 シスメックス株式会社 粒子分析装置とその粒子分画方法
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
GB0031463D0 (en) * 2000-12-21 2001-02-07 Univ Southampton Fibre laser
EP1371965B1 (en) * 2001-01-25 2015-04-29 Precision System Science Co., Ltd. Small object identifying device and its identifying method
US7072034B2 (en) * 2001-06-08 2006-07-04 Kla-Tencor Corporation Systems and methods for inspection of specimen surfaces
JP2002243987A (ja) * 2001-02-13 2002-08-28 Sony Corp 光結合装置
US6674947B2 (en) * 2001-02-23 2004-01-06 Fiberguide Industries, Inc. High density, angled optical fiber array and method
US6831934B2 (en) * 2001-05-29 2004-12-14 Apollo Instruments, Inc. Cladding pumped fiber laser
US7064329B2 (en) * 2001-08-21 2006-06-20 Franalytica, Inc. Amplifier-enhanced optical analysis system and method
IL146404A0 (en) * 2001-11-08 2002-07-25 E Afikin Computerized Dairy Ma Spectroscopic fluid analyzer
US20030091277A1 (en) * 2001-11-15 2003-05-15 Wenhui Mei Flattened laser scanning system
US7218811B2 (en) * 2002-01-10 2007-05-15 The Furukawa Electric Co., Ltd. Optical module, and multi-core optical collimator and lens housing therefor
DE10202999B4 (de) * 2002-01-26 2004-04-15 Palas Gmbh Partikel- Und Lasermesstechnik Verfahren und Vorrichtung zum Messen der Größenverteilung und Konzentration von Partikeln in einem Fluid
US6766086B1 (en) * 2002-03-01 2004-07-20 Fiberguide Industries, Inc. Optical fiber array with precise fiber positioning
US6700709B1 (en) * 2002-03-01 2004-03-02 Boston Laser Inc. Configuration of and method for optical beam shaping of diode laser bars
US6757475B2 (en) * 2002-06-14 2004-06-29 Fiberguide Industries, Inc. Optical fiber arrays with precise hole sizing
AU2003301548A1 (en) * 2002-10-24 2004-05-13 Fiberguide Industries, Inc. Optical fiber array assembly and method of making
WO2005033654A2 (en) * 2003-08-28 2005-04-14 The Regents Of The University Of Michigan Micro flow cytometer with multiangular waveguide detectors having spectral capabilities
WO2005052652A2 (en) * 2003-11-25 2005-06-09 Zygo Corporation Optical fiber connectors and systems including optical fiber connectors
US7248909B2 (en) * 2004-04-13 2007-07-24 The Regents Of The University Of California Method and apparatus for dynamically monitoring multiple in vivo tissue chromophores
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
CA2568791A1 (en) * 2004-06-01 2005-12-15 Trumpf Photonics Inc. Optimum matching of the output of a two-dimensional laser array stack to an optical fiber
JP2006131876A (ja) * 2004-10-07 2006-05-25 Nippon Shokubai Co Ltd 光実装材料用樹脂組成物及びその製造方法、並びに、該光実装材料用樹脂組成物を用いた光実装材料、光実装部品、及び、光モジュール
US20060192940A1 (en) * 2005-01-20 2006-08-31 Phi-Wilson Janette T Modular flow cytometry system
FR2884652B1 (fr) * 2005-04-19 2009-07-10 Femlight Sa Dispositif de generation d'impulsions laser amplifiees par fibres optiques a couches photoniques
US7299135B2 (en) * 2005-11-10 2007-11-20 Idexx Laboratories, Inc. Methods for identifying discrete populations (e.g., clusters) of data within a flow cytometer multi-dimensional data set
WO2008036083A1 (en) * 2006-09-19 2008-03-27 Vanderbilt University Microfluidic flow cytometer and applications of same
US7835000B2 (en) * 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
CN101889209A (zh) * 2007-10-22 2010-11-17 贝克顿·迪金森公司 评价在含有机基聚硅氧烷的悬浮液中蛋白质聚集的方法和用含蛋白质溶液的有机基聚硅氧烷涂布的医疗制品
US7843653B2 (en) * 2009-02-13 2010-11-30 Coherent, Inc. Achromatic flat top beam shaping

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040061853A1 (en) * 2002-09-27 2004-04-01 Blasenheim Barry J. Prism-based flow cytometry excitation optics
JP2005221327A (ja) * 2004-02-04 2005-08-18 Ngk Insulators Ltd 測定装置及びその製造方法
CN101065656A (zh) * 2004-09-28 2007-10-31 霍尼韦尔国际公司 具有远心光学系统的血细胞计数器
CN101061381A (zh) * 2004-11-18 2007-10-24 奥里巴Abx股份有限公司（简单形式） 利用配置的光引导装置的均匀照明光检查流体的装置
WO2008128213A1 (en) * 2007-04-12 2008-10-23 Regents Of The University Of Minnesota Systems and methods for analyzing a particulate

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11287379B2 (en) 2011-10-21 2022-03-29 Agilent Technologies, Inc. System and method for detecting multiple-excitation-induced light in a flow channel
US10648913B2 (en) 2011-10-21 2020-05-12 Acea Biosciences, Inc. System and method for detecting multiple-excitation-induced light in a flow channel
CN103424351A (zh) * 2012-05-17 2013-12-04 索尼公司 样本馈送装置、流式细胞仪以及样本馈送方法
US9606025B2 (en) 2012-05-17 2017-03-28 Sony Corporation Sample feeding apparatus, flow cytometer, and sample feeding method
US10184877B2 (en) 2012-05-17 2019-01-22 Sony Corporation Sample feeding apparatus, flow cytometer, and sample feeding method
CN103424343B (zh) * 2012-05-25 2015-06-10 阿自倍尔株式会社 光学式粒子检测装置以及粒子的检测方法
CN103424343A (zh) * 2012-05-25 2013-12-04 阿自倍尔株式会社 光学式粒子检测装置以及粒子的检测方法
CN104487818A (zh) * 2012-06-19 2015-04-01 美利坚合众国政府,由海军部长所代表 用于流动流体系统的远程多传感器光学颗粒监测器
CN104487818B (zh) * 2012-06-19 2017-07-07 美利坚合众国政府,由海军部长所代表 用于流动流体系统的远程多传感器光学颗粒监测器
CN104969055B (zh) * 2013-03-14 2018-10-12 雅培实验室 流式细胞仪系统的光束成形光学器件及其相关方法
CN104969055A (zh) * 2013-03-14 2015-10-07 雅培实验室 流式细胞仪系统的光束成形光学器件及其相关方法
CN110274853B (zh) * 2013-06-03 2022-12-06 嘉睿特热系统有限公司 颗粒检测系统及相关方法
CN110274853A (zh) * 2013-06-03 2019-09-24 爱克斯崔里斯科技有限公司 颗粒检测系统及相关方法
US10261080B2 (en) 2013-11-19 2019-04-16 Acea Biosciences, Inc. Optical detection system for flow cytometer, flow cytometer system and methods of use
CN105917211A (zh) * 2013-11-19 2016-08-31 艾森生物科学公司 用于流式细胞仪的光学引擎、流式细胞仪系统及使用方法
CN105917211B (zh) * 2013-11-19 2019-03-19 艾森生物科学公司 用于流式细胞仪的光学引擎、流式细胞仪系统及使用方法
CN108291867A (zh) * 2015-07-01 2018-07-17 曼塔仪器股份有限公司 用于液体中纳米颗粒的显微观察的专用试管组件和方法
CN107995950A (zh) * 2015-08-12 2018-05-04 生物辐射实验室股份有限公司 用于流式细胞术的多光谱滤波器剖析及质量控制
CN113702269A (zh) * 2016-01-21 2021-11-26 东京毅力科创株式会社 药液供给装置和涂敷显影系统
CN113702269B (zh) * 2016-01-21 2024-04-09 东京毅力科创株式会社 药液供给装置和涂敷显影系统
CN116359084A (zh) * 2016-03-16 2023-06-30 马尔文仪器有限公司 粒子表征的装置及方法
CN108627432A (zh) * 2016-03-16 2018-10-09 马尔文仪器有限公司 粒子表征
US12007275B2 (en) 2016-04-21 2024-06-11 Apple Inc. Optical system for reference switching
US12590837B2 (en) 2016-04-21 2026-03-31 Apple Inc. Optical system for reference switching
CN106053311A (zh) * 2016-08-16 2016-10-26 广东美的制冷设备有限公司 一种粉尘传感器
CN110446917A (zh) * 2017-03-23 2019-11-12 Atonarp株式会社 光学头和测量设备
US12332173B2 (en) 2017-09-29 2025-06-17 Apple Inc. Resolve path optical sampling architectures
CN111164415A (zh) * 2017-09-29 2020-05-15 苹果公司 路径解析的光学采样架构
US11579080B2 (en) 2017-09-29 2023-02-14 Apple Inc. Resolve path optical sampling architectures
CN116893160A (zh) * 2017-09-29 2023-10-17 苹果公司 路径解析的光学采样架构
CN107991221A (zh) * 2017-12-01 2018-05-04 天津大学 光纤式微颗粒检测与计数方法及系统
US11960131B2 (en) 2018-02-13 2024-04-16 Apple Inc. Integrated photonics device having integrated edge outcouplers
CN115901581A (zh) * 2018-03-30 2023-04-04 Idexx实验室公司 流式细胞仪的激光光学组件
CN108489885B (zh) * 2018-04-24 2024-09-24 中翰盛泰生物技术股份有限公司 一种用于流式荧光收集的光学系统及装置
CN108489885A (zh) * 2018-04-24 2018-09-04 中翰盛泰生物技术股份有限公司 一种用于流式荧光收集的光学系统及装置
CN113316715B (zh) * 2019-01-31 2024-03-15 快速定量微生物学股份有限公司 一种布置光学装置的盒、组件以及方法
CN113316715A (zh) * 2019-01-31 2021-08-27 快速定量微生物学股份有限公司 一种包括用于流体样品的通道的盒、包括盒的组件以及将光学装置与盒的通道对齐的方法
CN113711008B (zh) * 2019-03-13 2025-02-18 马克思-普朗克科学促进协会 用于粒子测试的装置和方法
US12235200B2 (en) 2019-03-13 2025-02-25 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus and methods for particle testing
CN113711008A (zh) * 2019-03-13 2021-11-26 马克思-普朗克科学促进协会 用于粒子测试的装置和方法
CN111361771A (zh) * 2020-03-23 2020-07-03 陈龙刚 一种细胞悬液分装装置
CN112014272A (zh) * 2020-08-10 2020-12-01 北京大学 一种纳米粒子传感器及纳米粒子检测方法
CN112014272B (zh) * 2020-08-10 2021-07-23 北京大学 一种纳米粒子传感器及纳米粒子检测方法
US11852318B2 (en) 2020-09-09 2023-12-26 Apple Inc. Optical system for noise mitigation
US12140291B2 (en) 2020-09-09 2024-11-12 Apple Inc. Optical system for noise mitigation
CN116438438A (zh) * 2020-11-10 2023-07-14 华盛顿大学 用于基于流动的单颗粒和/或单分子分析的方法和设备
CN117083552A (zh) * 2021-01-29 2023-11-17 相干公司 用于温度鲁棒性激光束组合和传送的光机械组件
CN117098980A (zh) * 2021-02-04 2023-11-21 贝克顿·迪金森公司 集成光询问模块及其使用方法
CN114112873A (zh) * 2021-11-23 2022-03-01 清华大学 用于流式细胞仪的片上荧光色散光路的波导设计
CN115452683A (zh) * 2022-08-05 2022-12-09 北京指真生物科技有限公司 一种荧光收集镜头及荧光收集系统

Also Published As

Publication number Publication date
WO2010099118A1 (en) 2010-09-02
JP2012519278A (ja) 2012-08-23
EP2401599A1 (en) 2012-01-04
US20100220315A1 (en) 2010-09-02

Similar Documents

Publication Publication Date Title
CN102334021A (zh) 用于流式细胞仪的稳定的光学系统
US11002659B2 (en) Optical detector for a particle sorting system
US7170597B1 (en) Microplate reader
US6800860B2 (en) Optical architectures for microvolume laser-scanning cytometers
US7709821B2 (en) Flow cytometer acquisition and detection system
CN101189504B (zh) 用于分选细胞的方法和设备
CN101023342A (zh) 用于检查试样表面的方法、装置以及荧光物质的应用
US11946803B1 (en) Raman spectroscopy equipment
US6066245A (en) Method and apparatus for scanning fluorescently labeled particles
US9086377B2 (en) Optical system for fluorescence detection and fine particle analyzing apparatus
ZA200704831B (en) Optical detector for a particle sorting system
US7632463B2 (en) Analysis apparatus and condenser
CN222965088U (zh) 侧向检测机构和光学检测装置
CN103018007A (zh) 一种光学感测系统及装置
CN117074279A (zh) 双通道侧向光收集装置及流式细胞仪
CN112858237A (zh) 全光谱微液滴荧光信号检测装置
MXPA01001887A (en) Novel optical architectures for microvolume laser-scanning cytometers

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20120125